Anders Nykjaer

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Holm Mai Marie; Nieto-Gonzalez Jose Luis; Vardya Irina; Vaegter Christian Bjerggaard; Nykjaer Anders; Jensen Kimmo
Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus.
Tauris Jacob; Christensen Erik Ilsø; Nykjaer Anders; Jacobsen Christian; Petersen Claus Munck; Ovesen Therese
Cubilin and megalin co-localize in the neonatal inner ear.
Willnow Thomas E; Petersen Claus M; Nykjaer Anders
VPS10P-domain receptors - regulators of neuronal viability and function.

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2009: Holm Mai Marie; Nieto-Gonzalez Jose Luis; Vardya Irina; Vaegter Christian Bjerggaard; Nykjaer Anders; Jensen Kimmo
Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(40):12412-8.
2009: Tauris Jacob; Christensen Erik Ilsø; Nykjaer Anders; Jacobsen Christian; Petersen Claus Munck; Ovesen Therese
Cubilin and megalin co-localize in the neonatal inner ear.
Audiology & neuro-otology 2009;14(4):267-78.
2008: Willnow Thomas E; Petersen Claus M; Nykjaer Anders
VPS10P-domain receptors - regulators of neuronal viability and function.
Nature reviews. Neuroscience 2008;9(12):899-909.
2008: Nielsen Morten S; Keat Sady J; Hamati Jida W; Madsen Peder; Gutzmann Jakob J; Engelsberg Arne; Pedersen Karen M; Gustafsen Camilla; Nykjaer Anders; Gliemann Jørgen; Hermans-Borgmeyer Irm; Kuhl Dietmar; Petersen Claus M; Hermey Guido
Different motifs regulate trafficking of SorCS1 isoforms.
Traffic (Copenhagen, Denmark) 2008;9(6):980-94.
2007: Jansen Pernille; Giehl Klaus; Nyengaard Jens R; Teng Kenneth; Lioubinski Oleg; Sjoegaard Susanne S; Breiderhoff Tilman; Gotthardt Michael; Lin Fuyu; Eilers Andreas; Petersen Claus M; Lewin Gary R; Hempstead Barbara L; Willnow Thomas E; Nykjaer Anders
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Nature neuroscience 2007;10(11):1449-57.
2007: Muhl Lars; Nykjaer Anders; Wygrecka Malgorzata; Monard Denis; Preissner Klaus T; Kanse Sandip M
Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP.
The Biochemical journal 2007;404(2):191-6.
2006: Petersen Helle Heibroch; Andreassen Thomas K; Breiderhoff Tilman; Bräsen Jan Hinrich; Schulz Herbert; Gross Volkmar; Gröne Hermann-Josef; Nykjaer Anders; Willnow Thomas E
Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin.
Molecular and cellular biology 2006;26(19):7236-45.
2006: Hermey Guido; Sjøgaard Susanne S; Petersen Claus Munck; Nykjaer Anders; Gliemann Jørgen
Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members.
The Biochemical journal 2006;395(2):285-93.
2005: Andersen Olav M; Reiche Juliane; Schmidt Vanessa; Gotthardt Michael; Spoelgen Robert; Behlke Joachim; von Arnim Christine A F; Breiderhoff Tilman; Jansen Pernille; Wu Xin; Bales Kelly R; Cappai Roberto; Masters Colin L; Gliemann Jørgen; Mufson Elliott J; Hyman Bradley T; Paul Steven M; Nykjaer Anders; Willnow Thomas E
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13461-6.
2005: Hammes Annette; Andreassen Thomas K; Spoelgen Robert; Raila Jens; Hubner Norbert; Schulz Herbert; Metzger Jochen; Schweigert Florian J; Luppa Peter B; Nykjaer Anders; Willnow Thomas E
Role of endocytosis in cellular uptake of sex steroids.
Cell 2005;122(5):751-62.
2005: Chen Zhe-Yu; Ieraci Alessandro; Teng Henry; Dall Henning; Meng Chui-Xiang; Herrera Daniel G; Nykjaer Anders; Hempstead Barbara L; Lee Francis S
Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(26):6156-66.
2005: Teng Henry K; Teng Kenneth K; Lee Ramee; Wright Saundrene; Tevar Seema; Almeida Ramiro D; Kermani Pouneh; Torkin Risa; Chen Zhe-Yu; Lee Francis S; Kraemer Rosemary T; Nykjaer Anders; Hempstead Barbara L
ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(22):5455-63.
2005: Nykjaer Anders; Willnow Thomas E; Petersen Claus Munck
p75NTR--live or let die.
Current opinion in neurobiology 2005;15(1):49-57.
2004: Westergaard Uffe B; Sørensen Esben S; Hermey Guido; Nielsen Morten S; Nykjaer Anders; Kirkegaard Kirstine; Jacobsen Christian; Gliemann Jørgen; Madsen Peder; Petersen Claus Munck
Functional organization of the sortilin Vps10p domain.
The Journal of biological chemistry 2004;279(48):50221-9.
2004: Gliemann Jørgen; Hermey Guido; Nykjaer Anders; Petersen Claus M; Jacobsen Christian; Andreasen Peter A
The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.
The Biochemical journal 2004;381(Pt 1):203-12.
2004: Nykjaer Anders; Lee Ramee; Teng Kenneth K; Jansen Pernille; Madsen Peder; Nielsen Morten S; Jacobsen Christian; Kliemannel Marco; Schwarz Elisabeth; Willnow Thomas E; Hempstead Barbara L; Petersen Claus M
Sortilin is essential for proNGF-induced neuronal cell death.
Nature 2004;427(6977):843-8.
2003: Leheste Jörg R; Melsen Flemming; Wellner Maren; Jansen Pernille; Schlichting Uwe; Renner-Müller Ingrid; Andreassen Troels T; Wolf Eckehard; Bachmann Sebastian; Nykjaer Anders; Willnow Thomas E
Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):247-9.
2003: Müller Dominik; Nykjaer Anders; Willnow Thomas E
From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia.
Annals of medicine 2003;35(5):290-9.
2002: Hilpert Jan; Wogensen Lise; Thykjaer Thomas; Wellner Maren; Schlichting Uwe; Orntoft Torben F; Bachmann Sebastian; Nykjaer Anders; Willnow Thomas E
Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism.
Kidney international 2002;62(5):1672-81.
2002: Nykjaer Anders; Willnow Thomas E
The low-density lipoprotein receptor gene family: a cellular Swiss army knife?
Trends in cell biology 2002;12(6):273-80.
2002: Willnow Thomas E; Nykjaer Anders
Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3.
Current opinion in lipidology 2002;13(3):255-60.
2001: Hilpert J; Vorum H; Burmeister R; Spoelgen R; Grishkovskaya I; Misselwitz R; Nykjaer A; Willnow T E
Efficient eukaryotic expression system for authentic human sex hormone-binding globulin.
The Biochemical journal 2001;360(Pt 3):609-15.
2001: Nykjaer A; Fyfe J C; Kozyraki R; Leheste J R; Jacobsen C; Nielsen M S; Verroust P J; Aminoff M; de la Chapelle A; Moestrup S K; Ray R; Gliemann J; Willnow T E; Christensen E I
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13895-900.
2001: Nielsen M S; Madsen P; Christensen E I; Nykjaer A; Gliemann J; Kasper D; Pohlmann R; Petersen C M
The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein.
The EMBO journal 2001;20(9):2180-90.
2001: Burmeister R; Boe I M; Nykjaer A; Jacobsen C; Moestrup S K; Verroust P; Christensen E I; Lund J; Willnow T E
A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney.
The Journal of biological chemistry 2001;276(16):13295-301.
2000: Gliemann J; Nykjaer A
[Transport receptors can signal, too]
Ugeskrift for laeger 2000;162(39):5222.
1999: Willnow T E; Nykjaer A; Herz J
Lipoprotein receptors: new roles for ancient proteins.
Nature cell biology 1999;1(6):E157-62.
1999: Leheste J R; Rolinski B; Vorum H; Hilpert J; Nykjaer A; Jacobsen C; Aucouturier P; Moskaug J O; Otto A; Christensen E I; Willnow T E
Megalin knockout mice as an animal model of low molecular weight proteinuria.
The American journal of pathology 1999;155(4):1361-70.
1999: Christensen E I; Moskaug J O; Vorum H; Jacobsen C; Gundersen T E; Nykjaer A; Blomhoff R; Willnow T E; Moestrup S K
Evidence for an essential role of megalin in transepithelial transport of retinol.
Journal of the American Society of Nephrology : JASN 1999;10(4):685-95.
1999: Hermans-Borgmeyer I; Hermey G; Nykjaer A; Schaller C
Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development.
Brain research. Molecular brain research 1999;65(2):216-9.
1999: Nykjaer A; Dragun D; Walther D; Vorum H; Jacobsen C; Herz J; Melsen F; Christensen E I; Willnow T E
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3.
Cell 1999;96(4):507-15.
1999: Hilpert J; Nykjaer A; Jacobsen C; Wallukat G; Nielsen R; Moestrup S K; Haller H; Luft F C; Christensen E I; Willnow T E
Megalin antagonizes activation of the parathyroid hormone receptor.
The Journal of biological chemistry 1999;274(9):5620-5.
1998: Nykjaer A; Christensen E I; Vorum H; Hager H; Petersen C M; Røigaard H; Min H Y; Vilhardt F; Møller L B; Kornfeld S; Gliemann J
Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction.
The Journal of cell biology 1998;141(3):815-28.
1998: Hermans-Borgmeyer I; Hampe W; Schinke B; Methner A; Nykjaer A; Süsens U; Fenger U; Herbarth B; Schaller H C
Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex.
Mechanisms of development 1998;70(1-2):65-76.
1997: Nykjaer A; Conese M; Christensen E I; Olson D; Cremona O; Gliemann J; Blasi F
Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes.
The EMBO journal 1997;16(10):2610-20.
1997: Petersen C M; Nielsen M S; Nykjaer A; Jacobsen L; Tommerup N; Rasmussen H H; Roigaard H; Gliemann J; Madsen P; Moestrup S K
Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography.
The Journal of biological chemistry 1997;272(6):3599-605.
1996: Jacobsen L; Madsen P; Moestrup S K; Lund A H; Tommerup N; Nykjaer A; Sottrup-Jensen L; Gliemann J; Petersen C M
Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein.
The Journal of biological chemistry 1996;271(49):31379-83.
1996: Petersen C M; Ellgaard L; Nykjaer A; Vilhardt F; Vorum H; Thøgersen H C; Nielsen M S; Jacobsen C; Moestrup S K; Gliemann J
The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II.
The EMBO journal 1996;15(16):4165-73.
1995: Conese M; Nykjaer A; Petersen C M; Cremona O; Pardi R; Andreasen P A; Gliemann J; Christensen E I; Blasi F
alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor.
The Journal of cell biology 1995;131(6 Pt 1):1609-22.
1995: Nielsen M S; Nykjaer A; Warshawsky I; Schwartz A L; Gliemann J
Analysis of ligand binding to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that lipoprotein lipase and the carboxyl-terminal domain of the receptor-associated protein bind to the same site.
The Journal of biological chemistry 1995;270(40):23713-9.
1995: Larnkjaer A; Nykjaer A; Olivecrona G; Thøgersen H; Ostergaard P B
Structure of heparin fragments with high affinity for lipoprotein lipase and inhibition of lipoprotein lipase binding to alpha 2-macroglobulin-receptor/low-density-lipoprotein-receptor-related protein by heparin fragments.
The Biochemical journal 1995;307 ( Pt 1)():205-14.
1994: Nykjaer A; Nielsen M; Lookene A; Meyer N; Røigaard H; Etzerodt M; Beisiegel U; Olivecrona G; Gliemann J
A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits lipase-mediated uptake of lipoprotein in cells.
The Journal of biological chemistry 1994;269(50):31747-55.
1994: Nykjaer A; Kjøller L; Cohen R L; Lawrence D A; Garni-Wagner B A; Todd R F; van Zonneveld A J; Gliemann J; Andreasen P A
Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor.
The Journal of biological chemistry 1994;269(41):25668-76.
1994: Nykjaer A; Kjøller L; Cohen R L; Lawrence D A; Gliemann J; Andreasen P A
Both pro-uPA and uPA: PAI-1 complex bind to the alpha 2-macroglobulin receptor/LDL receptor-related protein. Evidence for multiple independent contacts between the ligands and receptor.
Annals of the New York Academy of Sciences 1994;737():483-5.
1994: Gliemann J; Nykjaer A; Petersen C M; Jørgensen K E; Nielsen M; Andreasen P A; Christensen E I; Lookene A; Olivecrona G; Moestrup S K
The multiligand alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP). Binding and endocytosis of fluid phase and membrane-associated ligands.
Annals of the New York Academy of Sciences 1994;737():20-38.
1994: Andreasen P A; Sottrup-Jensen L; Kjøller L; Nykjaer A; Moestrup S K; Petersen C M; Gliemann J
Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes.
FEBS letters 1994;338(3):239-45.
1994: Nykjaer A; Møller B; Todd R F; Christensen T; Andreasen P A; Gliemann J; Petersen C M
Urokinase receptor. An activation antigen in human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(2):505-16.
1993: Gliemann J; Nykjaer A; Jensen P H; Moestrup S K
[Complement activation caused by beta-amyloid in Alzheimer's dementia]
Ugeskrift for laeger 1993;155(39):3135-6.
1993: Moestrup S K; Nielsen S; Andreasen P; Jørgensen K E; Nykjaer A; Røigaard H; Gliemann J; Christensen E I
Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes.
The Journal of biological chemistry 1993;268(22):16564-70.
1993: Nykjaer A; Bengtsson-Olivecrona G; Lookene A; Moestrup S K; Petersen C M; Weber W; Beisiegel U; Gliemann J
The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase.
The Journal of biological chemistry 1993;268(20):15048-55.
1993: Moestrup S K; Holtet T L; Etzerodt M; Thøgersen H C; Nykjaer A; Andreasen P A; Rasmussen H H; Sottrup-Jensen L; Gliemann J
Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha 2-macroglobulin receptor containing a cluster of eight complement-type repeats.
The Journal of biological chemistry 1993;268(18):13691-6.
1993: Gliemann J; Nykjaer A; Jensen P H; Moestrup S K
[Low density lipoprotein (LDL) receptor-related protein internalizes and degrades uPA-PA1 complexes and is essential for embryo implantation]
Ugeskrift for laeger 1993;155(13):981.
1992: Nykjaer A; Petersen C M; Møller B; Jensen P H; Moestrup S K; Holtet T L; Etzerodt M; Thøgersen H C; Munch M; Andreasen P A
Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.
The Journal of biological chemistry 1992;267(21):14543-6.
1992: Nykjaer A; Petersen C M; Møller B; Andreasen P A; Gliemann J
Identification and characterization of urokinase receptors in natural killer cells and T-cell-derived lymphokine activated killer cells.
FEBS letters 1992;300(1):13-7.
1990: Munck Petersen C; Davidsen O; Moestrup S K; Sonne O; Nykjaer A; Møller B K
Cellular targets and receptors for interleukin-6. II. Characterization of IL-6 binding and receptors in peripheral blood cells and macrophages.
European journal of clinical investigation 1990;20(4):377-84.
1990: Nykjaer A; Petersen C M; Christensen E I; Davidsen O; Gliemann J
Urokinase receptors in human monocytes.
Biochimica et biophysica acta 1990;1052(3):399-407.
1989: Jensen P H; Nykjaer A; Andreasen P A; Lund L R; Astedt B; Lecander I; Gliemann J
Urokinase binds to a plasminogen activator inhibitor type-2-like molecule in placental microvillous membranes.
Biochimica et biophysica acta 1989;986(1):135-40.
1989: Petersen C M; Nykjaer A; Christiansen B S; Heickendorff L; Mogensen S C; Møller B
Bioactive human recombinant tumor necrosis factor-alpha: an unstable dimer?
European journal of immunology 1989;19(10):1887-94.

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