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Jiyang O-Wang

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Keiji Masuda; Rika Ouchida; Masaki Hikida; Tomohiro Kurosaki; Masayuki Yokoi; Chikahide Masutani; Mineaki Seki; Richard D Wood; Fumio Hanaoka; Jiyang O-Wang
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes.
Akihiko Wada; Yuji Tada; Kiyoko Kawamura; Yuichi Takiguchi; Koichiro Tatsumi; Takayuki Kuriyama; T Takenouchi; Jiyang O-Wang; Masatoshi Tagawa
The effects of FasL on inflammation and tumor survival are dependent on its expression levels.
Keiji Masuda; Rika Ouchida; Masaki Hikida; Manabu Nakayama; Osamu Ohara; Tomohiro Kurosaki; Jiyang O-Wang
Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes.

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2007: Keiji Masuda; Rika Ouchida; Masaki Hikida; Tomohiro Kurosaki; Masayuki Yokoi; Chikahide Masutani; Mineaki Seki; Richard D Wood; Fumio Hanaoka; Jiyang O-Wang
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes.
The Journal of biological chemistry 2007;282(24):17387-94.
2007: Akihiko Wada; Yuji Tada; Kiyoko Kawamura; Yuichi Takiguchi; Koichiro Tatsumi; Takayuki Kuriyama; T Takenouchi; Jiyang O-Wang; Masatoshi Tagawa
The effects of FasL on inflammation and tumor survival are dependent on its expression levels.
Cancer gene therapy 2007;14(3):262-7.
2006: Keiji Masuda; Rika Ouchida; Masaki Hikida; Manabu Nakayama; Osamu Ohara; Tomohiro Kurosaki; Jiyang O-Wang
Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes.
DNA repair 2006;5(11):1384-91.
2006: Yukiteru Maeda; Lisa Fujimura; Jiyang O-Wang; Masahiko Hatano; Akemi Sakamoto; Masafumi Arima; Masaaki Ebara; Hidetoshi Ino; Toshihide Yamashita; Hiromitsu Saisho; Takeshi Tokuhisa
Role of Clast1 in development of cerebellar granule cells.
Brain research 2006;1104(1):18-26.
2006: Akiko Ukai; Takako Maruyama; Shigenobu Mochizuki; Rika Ouchida; Keiji Masuda; Kiyoko Kawamura; Masatoshi Tagawa; Kazuo Kinoshita; Akemi Sakamoto; Takeshi Tokuhisa; Jiyang O-Wang
Role of DNA polymerase theta in tolerance of endogenous and exogenous DNA damage in mouse B cells.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(2):111-21.
2005: Keiji Masuda; Randall S Davis; Takako Maruyama; Jennifer Zhang; Ti He; Max D Cooper; Jiyang O-Wang; Peter D Burrows
FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation.
Gene 2005;363():32-40.
2005: Keiji Masuda; Rika Ouchida; Arata Takeuchi; Takashi Saito; Haruhiko Koseki; Kiyoko Kawamura; Masatoshi Tagawa; Takeshi Tokuhisa; Takachika Azuma; Jiyang O-Wang
DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13986-91.
2005: Kyo-ichi Isono; Yu-Ichi Fujimura; Jun Shinga; Makoto Yamaki; Jiyang O-Wang; Yoshihiro Takihara; Yasuaki Murahashi; Yuki Takada; Yoko Mizutani-Koseki; Haruhiko Koseki
Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes.
Molecular and cellular biology 2005;25(15):6694-706.
2005: Yusuke Ohkubo; Masafumi Arima; Eggi Arguni; Seiji Okada; Kimihiro Yamashita; Sadaki Asari; Shintaro Obata; Akemi Sakamoto; Masahiko Hatano; Jiyang O-Wang; Masaaki Ebara; Hiromitsu Saisho; Takeshi Tokuhisa
A role for c-fos/activator protein 1 in B lymphocyte terminal differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7703-10.
2005: Clarisse Bavoux; Andreia Leopoldino; Valérie Bergoglio; Jiyang O-Wang; Tomoo Ogi; Anne Bieth; Jean-Gabriel Judde; Sergio Pena; Marie-France Poupon; Thomas Helleday; Masatoshi Tagawa; Carlosrenato Machado; Jean-Sébastien Hoffmann; Christophe Cazaux
Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.
Cancer research 2005;65(1):325-30.
2004: Yanqing Wang; Mika Seimiya; Kiyoko Kawamura; Ling Yu; Tomoo Ogi; Keizo Takenaga; Tomotane Shishikura; Akira Nakagawara; Shigeru Sakiyama; Masatoshi Tagawa; Jiyang O-Wang
Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53.
International journal of oncology 2004;25(1):161-5.
2004: Mika Seimiya; Akihiko Wada; Kiyoko Kawamura; Akemi Sakamoto; Yusuke Ohkubo; Seiji Okada; Masahiko Hatano; Takeshi Tokuhisa; Takeshi Watanabe; Hiromitsu Saisho; Masatoshi Tagawa; Jiyang O-Wang
Impaired lymphocyte development and function in Clast5/Stra13/DEC1-transgenic mice.
European journal of immunology 2004;34(5):1322-32.
2004: Kiyoko Kawamura; Rumana Bahar; Mika Seimiya; Masako Chiyo; Akihiko Wada; Seiji Okada; Masahiko Hatano; Takeshi Tokuhisa; Hideki Kimura; Satoshi Watanabe; Ichiro Honda; Shigeru Sakiyama; Masatoshi Tagawa; Jiyang O-Wang
DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers.
International journal of cancer. Journal international du cancer 2004;109(1):9-16.
2003: Ling Yu; Shin-ichi Ugai; Jiyang O-Wang; Masayoshi Namba; Kenji Kadomatsu; Takashi Muramatsu; Shuichiro Matsubara; Shigeru Sakiyama; Masatoshi Tagawa
Cell growth- and P53-dependent transcriptional activity of the midkine promoter confers suicide gene expression in tumor cells.
Oncology reports 2003;10(5):1301-5.
2003: Yuji Tada; Jiyang O-Wang; Ling Yu; Osamu Shimozato; Yan-Qing Wang; Yuichi Takiguchi; Koichiro Tatsumi; Takayuki Kuriyama; Keizo Takenaga; Shigeru Sakiyama; Masatoshi Tagawa
T-cell-dependent antitumor effects produced by CD40 ligand expressed on mouse lung carcinoma cells are linked with the maturation of dendritic cells and secretion of a variety of cytokines.
Cancer gene therapy 2003;10(6):451-6.
2003: Yuji Tada; Jiyang O-Wang; Akihiko Wada; Yuichi Takiguchi; Koichiro Tatsumi; Takayuki Kuriyama; Shigeru Sakiyama; Masatoshi Tagawa
Fas ligand-expressing tumors induce tumor-specific protective immunity in the inoculated hosts but vaccination with the apoptotic tumors suppresses antitumor immunity.
Cancer gene therapy 2003;10(2):134-40.
2003: Mika Seimiya; Jiyang O-Wang; Rumana Bahar; Kiyoko Kawamura; Yanqing Wang; Hiromitsu Saisho; Masatoshi Tagawa
Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas.
International journal of oncology 2003;22(2):301-4.
2003: Takashi Mitsui; Seiji Nomura; Mayumi Okada; Yasumasa Ohno; Honami Kobayashi; Yutaka Nakashima; Yasutaka Murata; Mikihito Takeuchi; Naohiko Kuno; Tetsuro Nagasaka; Jiyang O-Wang; Max D Cooper; Shigehiko Mizutani
Hypertension and angiotensin II hypersensitivity in aminopeptidase A-deficient mice.
Molecular medicine (Cambridge, Mass.) 2003;9(1-2):57-62.
2002: Rumana Bahar; Jiyang O-Wang; Kiyoko Kawamura; Mika Seimiya; Yanqing Wang; Masahiko Hatano; Seiji Okada; Takeshi Tokuhisa; Takeshi Watanabe; Masatoshi Tagawa
Growth retardation, polyploidy, and multinucleation induced by Clast3, a novel cell cycle-regulated protein.
The Journal of biological chemistry 2002;277(42):40012-9.
2002: Yuji Tada; Jiyang O-Wang; Yuichi Takiguchi; Koichiro Tatsumi; Takayuki Kuriyama; Seiji Okada; Takeshi Tokuhisa; Shigeru Sakiyama; Masatoshi Tagawa
Cutting edge: a novel role for Fas ligand in facilitating antigen acquisition by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2241-5.
2002: Jiyang O-Wang; Kagemasa Kajiwara; Kiyoko Kawamura; Minoru Kimura; Hiro Miyagishima; Haruhiko Koseki; Masatoshi Tagawa
An essential role for REV3 in mammalian cell survival: absence of REV3 induces p53-independent embryonic death.
Biochemical and biophysical research communications 2002;293(3):1132-7.
2002: Yuji Tada; Jiyang O-Wang; Keizo Takenaga; Yuichi Takiguchi; Koichiro Tatsumi; Takayuki Kuriyama; Masatoshi Tagawa
Expression of the TNF-alpha gene on mouse lung carcinoma cells suppresses spontaneous lung metastasis without affecting tumorigenicity.
Oncology reports 2002;9(3):585-8.
2002: Mika Seimiya; Rumana Bahar; Yanqing Wang; Kiyoko Kawamura; Yuji Tada; Seiji Okada; Masahiko Hatano; Takeshi Tokuhisa; Hiromitsu Saisho; Takeshi Watanabe; Masatoshi Tagawa; Jiyang O-Wang
Clast5/Stra13 is a negative regulator of B lymphocyte activation.
Biochemical and biophysical research communications 2002;292(1):121-7.
2002: Yuji Tada; Jiyang O-Wang; Mika Seimiya; Yuichi Takiguchi; Koichiro Tatsumi; Takayuki Kuriyama; Masatoshi Tagawa
Antitumor effects are produced by forced expression of membrane-bound but not soluble Fas ligand in murine lung carcinoma cells.
Anticancer research 2002;22(2A):831-6.
2002: Yuji Tada; Jiyang O-Wang; Yuichi Takiguchi; Koichiro Tatsumi; Takayuki Kuriyama; Masatoshi Tagawa
T cell dependent and independent antitumor immunity generated by the expression of Fas ligand on mouse lung carcinoma cells.
International journal of molecular medicine 2002;9(3):281-5.
2001: Jiyang O-Wang; K Kawamura; Y Tada; H Ohmori; H Kimura; Shigeru Sakiyama; Masatoshi Tagawa
DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.
Cancer research 2001;61(14):5366-9.
2001: Kiyoko Kawamura; Jiyang O-Wang; Rumana Bahar; N Koshikawa; Tomotane Shishikura; Akira Nakagawara; Shigeru Sakiyama; K Kajiwara; M Kimura; Masatoshi Tagawa
The error-prone DNA polymerase zeta catalytic subunit (Rev3) gene is ubiquitously expressed in normal and malignant human tissues.
International journal of oncology 2001;18(1):97-103.