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Koichi Obata

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Takashi Kondo; Tadayuki Oshima; Koichi Obata; Jun Sakurai; Charles H Knowles; Takayuki Matsumoto; Koichi Noguchi; Hiroto Miwa
Role of transient receptor potential A1 in gastric nociception.
T Kondo; Koichi Obata; K Miyoshi; Jun Sakurai; J Tanaka; Hiroto Miwa; Koichi Noguchi
Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats.
Kan Miyoshi; Koichi Obata; Takashi Kondo; Haruki Okamura; Koichi Noguchi
Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury.

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2010: Takashi Kondo; Tadayuki Oshima; Koichi Obata; Jun Sakurai; Charles H Knowles; Takayuki Matsumoto; Koichi Noguchi; Hiroto Miwa
Role of transient receptor potential A1 in gastric nociception.
Digestion 2010;82(3):150-5.
2009: T Kondo; Koichi Obata; K Miyoshi; Jun Sakurai; J Tanaka; Hiroto Miwa; Koichi Noguchi
Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats.
Gut 2009;58(10):1342-52.
2008: Kan Miyoshi; Koichi Obata; Takashi Kondo; Haruki Okamura; Koichi Noguchi
Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(48):12775-87.
2008: Tetsuo Fukuoka; Kimiko Kobayashi; Hiroki Yamanaka; Koichi Obata; Yi Dai; Koichi Noguchi
Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons.
The Journal of comparative neurology 2008;510(2):188-206.
2008: Koichi Obata; Hirokazu Katsura; Kan Miyoshi; Takashi Kondo; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Shizuo Akira; Koichi Noguchi
Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury.
Journal of neurochemistry 2008;105(6):2249-59.
2008: Koichi Obata; Koichi Noguchi
[Contribution of primary sensory neurons and spinal glial cells to pathomechanisms of neuropathic pain].
Brain and nerve = Shinkei kenkyū no shinpo 2008;60(5):483-92.
2008: Shenglan Wang; Yi Dai; Tetsuo Fukuoka; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Xiuyu Cui; Makoto Tominaga; Koichi Noguchi
Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain.
Brain : a journal of neurology 2008;131(Pt 5):1241-51.
2008: Hirokazu Katsura; Koichi Obata; Kan Miyoshi; Takashi Kondo; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Masafumi Sakagami; Koichi Noguchi
Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury.
Glia 2008;56(7):723-33.
2008: Jun Sakurai; Koichi Obata; Noriyuki Ozaki; Atsushi Tokunaga; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Takashi Kondo; Kan Miyoshi; Yasuo Sugiura; Takayuki Matsumoto; Hiroto Miwa; Koichi Noguchi
Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats.
Gastroenterology 2008;134(4):1094-103.
2008: Kimiko Kobayashi; Hiroki Yamanaka; Tetsuo Fukuoka; Yi Dai; Koichi Obata; Koichi Noguchi
P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(11):2892-902.
2008: Xiu-Yu Cui; Yi Dai; Sheng-Lan Wang; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Jun Chen; Koichi Noguchi
Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia.
Molecular pain 2008;4():17.
2007: Hiroki Yamanaka; Koichi Obata; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to neuropathic pain.
Neuroscience 2007;150(1):202-11.
2007: Hirokazu Katsura; Koichi Obata; Toshiyuki Mizushima; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Masafumi Sakagami; Koichi Noguchi
Activation of extracellular signal-regulated protein kinases 5 in primary afferent neurons contributes to heat and cold hyperalgesia after inflammation.
Journal of neurochemistry 2007;102(5):1614-24.
2007: Koichi Obata; Hirokazu Katsura; Toshiyuki Mizushima; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
Roles of extracellular signal-regulated protein kinases 5 in spinal microglia and primary sensory neurons for neuropathic pain.
Journal of neurochemistry 2007;102(5):1569-84.
2007: Yi Dai; Shenglan Wang; Makoto Tominaga; Satoshi Yamamoto; Tetsuo Fukuoka; Tomohiro Higashi; Kimiko Kobayashi; Koichi Obata; Hiroki Yamanaka; Koichi Noguchi
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain.
The Journal of clinical investigation 2007;117(7):1979-87.
2007: Toyoko Kozai; Hiroki Yamanaka; Yi Dai; Koichi Obata; Kimiko Kobayashi; Takashi Mashimo; Koichi Noguchi
Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury.
Glia 2007;55(6):595-603.
2007: Toshiyuki Mizushima; Koichi Obata; Hirokazu Katsura; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Takashi Mashimo; Koichi Noguchi
Intensity-dependent activation of extracellular signal-regulated protein kinase 5 in sensory neurons contributes to pain hypersensitivity.
The Journal of pharmacology and experimental therapeutics 2007;321(1):28-34.
2007: Hiroki Yamanaka; Koichi Obata; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain.
The European journal of neuroscience 2007;25(4):1097-111.
2007: Tomokazu Fukui; Yi Dai; Koichi Iwata; Hiroshi Kamo; Hiroki Yamanaka; Koichi Obata; Kimiko Kobayashi; Shenglan Wang; Xiuyu Cui; Shinichi Yoshiya; Koichi Noguchi
Frequency-dependent ERK phosphorylation in spinal neurons by electric stimulation of the sciatic nerve and the role in electrophysiological activity.
Molecular pain 2007;3():18.
2006: Koichi Obata; Hirokazu Katsura; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Koichi Noguchi
Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(46):11974-86.
2006: Kimiko Kobayashi; Tetsuo Fukuoka; Hiroki Yamanaka; Hirok Iyamanaka; Yi Dai; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord.
The Journal of comparative neurology 2006;498(4):443-54.
2006: Hirokazu Katsura; Koichi Obata; Toshiyuki Mizushima; Jun Sakurai; Kimiko Kobayashi; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Masafumi Sakagami; Koichi Noguchi
Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(34):8680-90.
2006: Wan-Jun Zhu; Yi Dai; Tetsuo Fukuoka; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Obata; Shenglan Wang; Koichi Noguchi
Agonist of proteinase-activated receptor 2 increases painful behavior produced by alpha, beta-methylene adenosine 5'-triphosphate.
Neuroreport 2006;17(12):1257-61.
2006: Toshiyuki Mizushima; Koichi Obata; Hirokazu Katsura; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Takashi Mashimo; Koichi Noguchi
Noxious cold stimulation induces mitogen-activated protein kinase activation in transient receptor potential (TRP) channels TRPA1- and TRPM8-containing small sensory neurons.
Neuroscience 2006;140(4):1337-48.
2006: Daisuke Seino; Atsushi Tokunaga; Toshiya Tachibana; Shinichi Yoshiya; Yi Dai; Koichi Obata; Hiroki Yamanaka; Kimiko Kobayashi; Koichi Noguchi
The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint.
Pain 2006;123(1-2):193-203.
2006: Hirokazu Katsura; Koichi Obata; Toshiyuki Mizushima; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Masafumi Sakagami; Koichi Noguchi
Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats.
Experimental neurology 2006;200(1):112-23.
2006: Koichi Obata; Koichi Noguchi
BDNF in sensory neurons and chronic pain.
Neuroscience research 2006;55(1):1-10.
2006: Koichi Obata; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Toshiyuki Mizushima; Hirokazu Katsura; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior.
Neuroscience 2006;137(3):961-70.
2005: Kimiko Kobayashi; Tetsuo Fukuoka; Koichi Obata; Hiroki Yamanaka; Yi Dai; Atsushi Tokunaga; Koichi Noguchi
Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors.
The Journal of comparative neurology 2005;493(4):596-606.
2005: Koichi Obata; Hirokazu Katsura; Toshiyuki Mizushima; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Makoto Tominaga; Koichi Noguchi
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury.
The Journal of clinical investigation 2005;115(9):2393-401.
2005: Yi Dai; Hu Wang; Akiko Ogawa; Hiroki Yamanaka; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy.
The European journal of neuroscience 2005;21(9):2467-74.
2005: Wan-Jun Zhu; Hiroki Yamanaka; Koichi Obata; Yi Dai; Kimiko Kobayashi; Toyoko Kozai; Atsushi Tokunaga; Koichi Noguchi
Expression of mRNA for four subtypes of the proteinase-activated receptor in rat dorsal root ganglia.
Brain research 2005;1041(2):205-11.
2005: Kimiko Kobayashi; Tetsuo Fukuoka; Hiroki Yamanaka; Yi Dai; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat.
The Journal of comparative neurology 2005;481(4):377-90.
2005: Hiroki Yamanaka; Koichi Obata; Tetsuo Fukuoka; Yi Dai; Kimiko Kobayashi; Atsushi Tokunaga; Koichi Noguchi
Induction of plasminogen activator inhibitor-1 and -2 in dorsal root ganglion neurons after peripheral nerve injury.
Neuroscience 2005;132(1):183-91.
2005: Toshiyuki Mizushima; Koichi Obata; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Takashi Mashimo; Koichi Noguchi
Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia.
Pain 2005;113(1-2):51-60.
2004: Koichi Obata; Hiroki Yamanaka; Yi Dai; Toshiyuki Mizushima; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats.
The European journal of neuroscience 2004;20(11):2881-95.
2004: Koichi Obata; Hiroki Yamanaka; Kimiko Kobayashi; Yi Dai; Toshiyuki Mizushima; Hirokazu Katsura; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(45):10211-22.
2004: Koichi Obata; Hiroki Yamanaka; Yi Dai; Toshiyuki Mizushima; Tetsuo Fukuoka; Atsushi Tokunaga; Hideki Yoshikawa; Koichi Noguchi
Contribution of degeneration of motor and sensory fibers to pain behavior and the changes in neurotrophic factors in rat dorsal root ganglion.
Experimental neurology 2004;188(1):149-60.
2004: Yi Liu; Koichi Obata; Hiroki Yamanaka; Yi Dai; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
Activation of extracellular signal-regulated protein kinase in dorsal horn neurons in the rat neuropathic intermittent claudication model.
Pain 2004;109(1-2):64-72.
2004: Koichi Obata; Koichi Noguchi
MAPK activation in nociceptive neurons and pain hypersensitivity.
Life sciences 2004;74(21):2643-53.
2004: Yi Dai; Tetsuo Fukuoka; Hu Wang; Hiroki Yamanaka; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons.
Pain 2004;108(3):258-66.
2004: Hu Wang; Yi Dai; Tetsuo Fukuoka; Hiroki Yamanaka; Koichi Obata; Atsushi Tokunaga; Koichi Noguchi
Enhancement of stimulation-induced ERK activation in the spinal dorsal horn and gracile nucleus neurons in rats with peripheral nerve injury.
The European journal of neuroscience 2004;19(4):884-90.
2004: Koichi Obata; Hiroki Yamanaka; Yi Dai; Toshiyuki Mizushima; Tetsuo Fukuoka; Atsushi Tokunaga; Koichi Noguchi
Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body.
Neuroscience 2004;126(4):1011-21.
2004: Hiroki Yamanaka; Koichi Obata; Tetsuo Fukuoka; Yi Dai; Kimiko Kobayashi; Atsushi Tokunaga; Koichi Noguchi
Tissue plasminogen activator in primary afferents induces dorsal horn excitability and pain response after peripheral nerve injury.
The European journal of neuroscience 2004;19(1):93-102.
2003: Koichi Obata; Hiroki Yamanaka; Yi Dai; Toshiya Tachibana; Tetsuo Fukuoka; Atsushi Tokunaga; Hideki Yoshikawa; Koichi Noguchi
Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(10):4117-26.
2003: Koichi Obata; Hiroki Yamanaka; Tetsuo Fukuoka; Dai Yi; Atsushi Tokunaga; Norio Hashimoto; Hideki Yoshikawa; Koichi Noguchi
Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats.
Pain 2003;101(1-2):65-77.
2002: Koichi Obata; Hiroaki Tsujino; Hiroki Yamanaka; Dai Yi; Tetsuo Fukuoka; Norio Hashimoto; Kazuo Yonenobu; Hideki Yoshikawa; Koichi Noguchi
Expression of neurotrophic factors in the dorsal root ganglion in a rat model of lumbar disc herniation.
Pain 2002;99(1-2):121-32.
2001: Norio Hashimoto; Hiroki Yamanaka; Tetsuo Fukuoka; Koichi Obata; Takashi Mashimo; Koichi Noguchi
Expression of hepatocyte growth factor in primary sensory neurons of adult rats.
Brain research. Molecular brain research 2001;97(1):83-8.
2001: Norio Hashimoto; Hiroki Yamanaka; Tetsuo Fukuoka; Yi Dai; Koichi Obata; Takashi Mashimo; Koichi Noguchi
Expression of HGF and cMet in the peripheral nervous system of adult rats following sciatic nerve injury.
Neuroreport 2001;12(7):1403-7.