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Satoshi Obika

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Kunihiko Morihiro; Tetsuya Kodama; Yoshihiro Moai; Rakesh N Veedu; Satoshi Obika
Selenomethylene locked nucleic Acid enables reversible hybridization in response to redox changes.
Yoshiyuki Hari; Takashi Osawa; Satoshi Obika
Synthesis and duplex-forming ability of oligonucleotides containing 4'-carboxythymidine analogs.
Aiko Yahara; Masaki Yamaguchi; Tsuyoshi Yamamoto; Takashi Osawa; Ajaya Ram Shrestha; Yoshiyuki Hari; Tetsuya Kodama; Masaru Nishida; Satoshi Obika
Amido-bridged nucleic acids (AmNAs): synthesis, duplex stability, nuclease resistance, and in vitro antisense potency.

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2013: Kunihiko Morihiro; Tetsuya Kodama; Yoshihiro Moai; Rakesh N Veedu; Satoshi Obika
Selenomethylene locked nucleic Acid enables reversible hybridization in response to redox changes.
Angewandte Chemie (International ed. in English) 2013;52(19):5074-8.
2012: Yoshiyuki Hari; Takashi Osawa; Satoshi Obika
Synthesis and duplex-forming ability of oligonucleotides containing 4'-carboxythymidine analogs.
Organic & biomolecular chemistry 2012;10(48):9639-49.
2012: Aiko Yahara; Masaki Yamaguchi; Tsuyoshi Yamamoto; Takashi Osawa; Ajaya Ram Shrestha; Yoshiyuki Hari; Tetsuya Kodama; Masaru Nishida; Satoshi Obika
Amido-bridged nucleic acids (AmNAs): synthesis, duplex stability, nuclease resistance, and in vitro antisense potency.
Chembiochem : a European journal of chemical biology 2012;13(17):2513-6.
2012: Masahiro Ikejiri; Takeshi Imanishi; Satoshi Obika; Moe Tsuchino; Takao Yamaguchi; Yoshiko Chihara; Kazuyuki Miyashita
Design and concise synthesis of a novel type of green fluorescent protein chromophore analogue.
Organic letters 2012;14(17):4406-9.
2012: Yuji Kawada; Tetsuya Kodama; Kazuyuki Miyashita; Takeshi Imanishi; Satoshi Obika
Synthesis and evaluation of novel caged DNA alkylating agents bearing 3,4-epoxypiperidine structure.
Organic & biomolecular chemistry 2012;10(26):5102-8.
2012: Hidetaka Torigoe; Takeshi Imanishi; Osamu Nakagawa; Satoshi Obika; Kiyomi Sasaki
Chemical modification of triplex-forming oligonucleotide to promote pyrimidine motif triplex formation at physiological pH.
Biochimie 2012;94(4):1032-40.
2012: Shunsuke Wada; Tsuyoshi Yamamoto; Tetsuji Yamaoka; Moeka Nakatani; Satoshi Obika; Masa-Aki Shibata; Hidetaka Torigoe; Mariko Harada-Shiba
Development of a 2',4'-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In Vivo.
Molecular therapy. Nucleic acids 2012;1():e45.
2012: Tsuyoshi Yamamoto; Tetsuji Yamaoka; Hidenori Yasuhara; Mariko Harada-Shiba; Takeshi Imanishi; Moeka Nakatani; Keisuke Narukawa; Kiyomi Sasaki; Masa-Aki Shibata; Hidetaka Torigoe; Shunsuke Wada; Satoshi Obika
Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice.
Molecular therapy. Nucleic acids 2012;1():e22.
2012: Tsuyoshi Yamamoto; Hidenori Yasuhara; Mariko Harada-Shiba; Takeshi Imanishi; Fumito Wada; Satoshi Obika
Superior Silencing by 2',4'-BNA(NC)-Based Short Antisense Oligonucleotides Compared to 2',4'-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors.
Journal of nucleic acids 2012;2012():707323.
2011: Kazuto Mori; Tetsuya Kodama; Satoshi Obika
Design, synthesis, and properties of boat-shaped glucopyranosyl nucleic acid.
Organic letters 2011;13(22):6050-3.
2011: Kazuto Mori; Takeshi Baba; Tetsuya Kodama; Satoshi Obika
Bridged nucleic acid conjugates at 6'-thiol: synthesis, hybridization properties and nuclease resistances.
Organic & biomolecular chemistry 2011;9(14):5272-9.
2011: Kunihiko Morihiro; Tetsuya Kodama; Satoshi Obika
Benzylidene acetal type bridged nucleic acids: changes in properties upon cleavage of the bridge triggered by external stimuli.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(28):7918-26.
2011: Yoshiyuki Hari; Masaaki Akabane; Yuri Hatanaka; Motoi Nakahara; Satoshi Obika
A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex DNA.
Chemical communications (Cambridge, England) 2011;47(15):4424-6.
2011: Tsuyoshi Yamamoto; Moeka Nakatani; Keisuke Narukawa; Satoshi Obika
Antisense drug discovery and development.
Future medicinal chemistry 2011;3(3):339-65.
2011: Hidetaka Torigoe; S M Abdur Rahman; Hiroko Takuma; Norihiro Sato; Takeshi Imanishi; Satoshi Obika; Kiyomi Sasaki
2'-O,4'-C-aminomethylene-bridged nucleic acid modification with enhancement of nuclease resistance promotes pyrimidine motif triplex nucleic acid formation at physiological pH.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(9):2742-51.
2011: Yoshiyuki Hari; Motoi Nakahara; Juanjuan Pang; Masaaki Akabane; Takeshi Kuboyama; Satoshi Obika
Synthesis and triplex-forming ability of oligonucleotides bearing 1-substituted 1H-1,2,3-triazole nucleobases.
Bioorganic & medicinal chemistry 2011;19(3):1162-6.
2011: Yoshiyuki Hari; Takeshi Imanishi; Tetsuya Kodama; Satoshi Obika
2'-O,4'-C-methyleneoxymethylene bridged nucleic acids (2',4'-BNA(COC)).
Methods in molecular biology (Clifton, N.J.) 2011;764():31-57.
2011: Hidetaka Torigoe; S M Abdur Rahman; Hiroko Takuma; Norihiro Sato; Takeshi Imanishi; Satoshi Obika; Kiyomi Sasaki
Interrupted 2'-o,4'-C-aminomethylene bridged nucleic acid modification enhances pyrimidine motif triplex-forming ability and nuclease resistance under physiological condition.
Nucleosides, nucleotides & nucleic acids 2011;30(1):63-81.
2011: Takeshi Kuboyama; Motoi Nakahara; Masafumi Yoshino; Yilong Cui; Takeo Sako; Yasuhiro Wada; Takeshi Imanishi; Satoshi Obika; Yasuyoshi Watanabe; Masaaki Suzuki; Hisashi Doi
Stoichiometry-focused (18)F-labeling of alkyne-substituted oligodeoxynucleotides using azido([(18)F]fluoromethyl)benzenes by Cu-catalyzed Huisgen reaction.
Bioorganic & medicinal chemistry 2011;19(1):249-55.
2010: Takeshi Baba; Tetsuya Kodama; Kazuto Mori; Takeshi Imanishi; Satoshi Obika
A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes.
Chemical communications (Cambridge, England) 2010;46(42):8058-60.
2010: Kosuke Ramon Ito; Tetsuya Kodama; Masaharu Tomizu; Yoshinori Negoro; Ayako Orita; Tomohisa Osaki; Noritsugu Hosoki; Takaya Tanaka; Takeshi Imanishi; Satoshi Obika
Double-stranded DNA-templated cleavage of oligonucleotides containing a P3'->N5' linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity.
Nucleic acids research 2010;38(20):7332-42.
2010: Yoshiyuki Hari; Sachiko Matsugu; Hiroyasu Inohara; Yuri Hatanaka; Masaaki Akabane; Takeshi Imanishi; Satoshi Obika
2',4'-BNA bearing a 2-pyridine nucleobase for CG base pair recognition in the parallel motif triplex DNA.
Organic & biomolecular chemistry 2010;8(18):4176-80.
2010: Masaru Nishida; Takeshi Baba; Tetsuya Kodama; Aiko Yahara; Takeshi Imanishi; Satoshi Obika
Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure.
Chemical communications (Cambridge, England) 2010;46(29):5283-5.
2010: S M Abdur Rahman; Hiroyuki Sato; Naoto Tsuda; Sunao Haitani; Keisuke Narukawa; Takeshi Imanishi; Satoshi Obika
RNA interference with 2',4'-bridged nucleic acid analogues.
Bioorganic & medicinal chemistry 2010;18(10):3474-80.
2009: Kunihiko Morihiro; Tetsuya Kodama; Masaru Nishida; Takeshi Imanishi; Satoshi Obika
Synthesis of light-responsive bridged nucleic acid and changes in affinity with complementary ssRNA.
Chembiochem : a European journal of chemical biology 2009;10(11):1784-8.
2009: Motoi Nakahara; Takeshi Kuboyama; Akihiro Izawa; Yoshiyuki Hari; Takeshi Imanishi; Satoshi Obika
Synthesis and base-pairing properties of C-nucleotides having 1-substituted 1H-1,2,3-triazoles.
Bioorganic & medicinal chemistry letters 2009;19(12):3316-9.
2009: Hidetaka Torigoe; Atushi Maruyama; Satoshi Obika; Takeshi Imanishi; Takuma Katayama
Synergistic stabilization of nucleic acid assembly by 2'-O,4'-C-methylene-bridged nucleic acid modification and additions of comb-type cationic copolymers.
Biochemistry 2009;48(15):3545-53.
2009: Yasunori Mitsuoka; Tetsuya Kodama; Ryo Ohnishi; Yoshiyuki Hari; Takeshi Imanishi; Satoshi Obika
A bridged nucleic acid, 2',4'-BNA COC: synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2',4'-BNA COC monomers and RNA-selective nucleic-acid recognition.
Nucleic acids research 2009;37(4):1225-38.
2009: Kunihiko Morihiro; Tetsuya Kodama; Masaru Nishida; Takeshi Imanishi; Satoshi Obika
Development of light-responsive BNA toward the spatiotemporal control of gene expression.
Nucleic acids symposium series (2004) 2009;(53):187-8.
2009: Kiyomi Sasaki; S M Abdur Rahman; Norihiro Sato; Satoshi Obika; Takeshi Imanishi; Hidetaka Torigoe
Promotion of triplex formation by 3'-amino-2'-O,4'-C-methylene bridged nucleic acid modification.
Nucleic acids symposium series (2004) 2009;(53):159-60.
2009: Takeshi Baba; Tetsuya Kodama; Takeshi Imanishi; Satoshi Obika
Synthesis and properties of a novel artificial nucleoside that acts as a redox switch.
Nucleic acids symposium series (2004) 2009;(53):107-8.
2009: Aiko Yahara; Masaru Nishida; Takeshi Baba; Tetsuya Kodama; Takeshi Imanishi; Satoshi Obika
Synthesis and properties of a novel 2',4'-BNA bearing a urea bridged structure.
Nucleic acids symposium series (2004) 2009;(53):11-2.
2008: Satoshi Obika; S M Abdur Rahman; Bingbing Song; Mayumi Onoda; Makoto Koizumi; Koji Morita; Takeshi Imanishi
Synthesis and properties of 3'-amino-2',4'-BNA, a bridged nucleic acid with a N3'-->P5' phosphoramidate linkage.
Bioorganic & medicinal chemistry 2008;16(20):9230-7.
2008: S M Abdur Rahman; Sayori Seki; Satoshi Obika; Haruhisa Yoshikawa; Kazuyuki Miyashita; Takeshi Imanishi
Design, synthesis, and properties of 2',4'-BNA(NC): a bridged nucleic acid analogue.
Journal of the American Chemical Society 2008;130(14):4886-96.
2008: Satoshi Obika; Hidenori Inohara; Yoshiyuki Hari; Takeshi Imanishi
Recognition of T.A interruption by 2',4'-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation.
Bioorganic & medicinal chemistry 2008;16(6):2945-54.
2008: Kiyomi Sasaki; S M Abdur Rahman; Satoshi Obika; Takeshi Imanishi; Hidetaka Torigoe
Promotion of triplex formation by 2'-O,4'-C-aminomethylene bridged nucleic acid (2',4'-BNA NC) modification.
Nucleic acids symposium series (2004) 2008;(52):419-20.
2008: Tetsuya Miyoshi; Tetsuya Kodama; Satoshi Obika; Takeshi Imanishi
Design and chemical synthesis of a 2',4'-BNA probe for 7,8-dihydro-8-oxoguanine-containing double stranded DNA.
Nucleic acids symposium series (2004) 2008;(52):305-6.
2007: Satoshi Obika; Masaharu Tomizu; Yoshinori Negoro; Ayako Orita; Osamu Nakagawa; Takeshi Imanishi
Double-stranded DNA-templated oligonucleotide digestion triggered by triplex formation.
Chembiochem : a European journal of chemical biology 2007;8(16):1924-8.
2007: Kazuyuki Miyashita; S M Abdur Rahman; Sayori Seki; Satoshi Obika; Takeshi Imanishi
N-Methyl substituted 2',4'- BNANC: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization.
Chemical communications (Cambridge, England) 2007;(36):3765-7.
2007: S M Abdur Rahman; Sayori Seki; Kazushige Utsuki; Satoshi Obika; Kazuyuki Miyashita; Takeshi Imanishi
2',4'-BNA(NC): a novel bridged nucleic acid analogue with excellent hybridizing and nuclease resistance profiles.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1625-8.
2007: Tomohisa Osaki; Satoshi Obika; Yasuki Harada; Yasunori Mitsuoka; Kensaku Sugaya; Mitsuaki Sekiguchi; Somjing Roongjang; Takeshi Imanishi
Synthesis of novel 2'-deoxy type trans-3',4'-bridged nucleic acid.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1079-82.
2007: Satoshi Obika; Masaharu Tomizu; Yoshinori Negoro; Tomohisa Osaki; Ayako Orita; Yuji Ueyama; Osamu Nakagawa; Takeshi Imanishi
Acid-mediated cleavage of oligonucleotide P3' --> N5' phosphoramidates triggered by sequence-specific triplex formation.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):893-6.
2007: Keisuke Tachibana; Tatsuya Katayama; Chihiro Ueda; Mikako Sumitomo; Masayuki Tagami; Kenji Ishimoto; Daisuke Yamasaki; Toshiya Tanaka; Takao Hamakubo; Juro Sakai; Tatsuhiko Kodama; Satoshi Obika; Takeshi Imanishi; Takefumi Doi
Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells.
Nucleic acids symposium series (2004) 2007;(51):441-2.
2007: Tetsuya Kodama; Chieko Matsuo; Hidetsugu Ori; Satoshi Obika; Kazuyuki Miyashita; Takeshi Imanishi
Synthesis and evaluation of a novel 2',5'-bridged nucleic acid with sugar conformation fixed to S-type by N-O linkage.
Nucleic acids symposium series (2004) 2007;(51):159-60.
2007: Masaru Nishida; Tetsuya Kodama; Satoshi Obika; Takeshi Imanishi
Synthesis and chemical properties of a novel 2',4'-bridged nucleic acid analogue with a seven-membered cyclic carbamate structure.
Nucleic acids symposium series (2004) 2007;(51):157-8.
2007: Kensaku Sugaya; Yasuki Harada; Yasunori Mitsuoka; Tomohisa Osaki; Satoshi Obika; Tetsuya Kodama; Takeshi Imanishi
Synthesis and properties of a 2'-deoxy analogue of trans-3',4'-BNA with an S-type sugar conformation.
Nucleic acids symposium series (2004) 2007;(51):155-6.
2007: Somjing Roongjang; Kurena Takahashi; Satoshi Obika; Takeshi Imanishi
Inhibition of bcl-xL expression by antisense oligonucleotides containing various bridged nucleic acids (BNAs).
Nucleic acids symposium series (2004) 2007;(51):113-4.
2007: S M Abdur Rahman; Sayori Seki; Satoshi Obika; Sunao Haitani; Kazuyuki Miyashita; Takeshi Imanishi
Highly stable pyrimidine-motif triplex formation at physiological pH values by a bridged nucleic acid analogue.
Angewandte Chemie (International ed. in English) 2007;46(23):4306-9.
2006: Mitsuaki Sekiguchi; Satoshi Obika; Yasuki Harada; Tomohisa Osaki; Roongjang Somjing; Yasunori Mitsuoka; Nao Shibata; Miyuki Masaki; Takeshi Imanishi
Synthesis and properties of trans-3',4'-bridged nucleic acids having typical S-type sugar conformation.
The Journal of organic chemistry 2006;71(4):1306-16.
2006: Yoshiyuki Hari; Satoshi Obika; Ryo Ohnishi; Ken Eguchi; Tomohisa Osaki; Hirofumi Ohishi; Takeshi Imanishi
Synthesis and properties of 2'-O,4'-C-methyleneoxymethylene bridged nucleic acid.
Bioorganic & medicinal chemistry 2006;14(4):1029-38.
2006: Somjing Roongjang; Kurena Takahashi; Myunji Park; Satoshi Obika; Takeshi Imanishi
Antisense activity of 2',4'-BNA targeted to bcl-xL gene in HepG2 cell.
Nucleic acids symposium series (2004) 2006;(50):289-90.
2006: S M Abdur Rahman; Sayori Seki; Kazushige Utsuki; Satoshi Obika; Kazuyuki Miyashita; Takeshi Imanishi
High-affinity RNA mimicking binding of 2',4'-BNANC towards complementary strands: a comparative study with 2',4'-BNA/LNA.
Nucleic acids symposium series (2004) 2006;(50):195-6.
2006: Yasunori Mitsuoka; Ryo Ohnishi; Yoshiyuki Hari; Satoshi Obika; Takeshi Imanishi
Synthesis of 2',4'-BNACOC bearing a purine nucleobase.
Nucleic acids symposium series (2004) 2006;(50):13-4.
2005: Yoshiyuki Hari; Satoshi Obika; Hidenori Inohara; Masahiro Ikejiri; Daisuke Une; Takeshi Imanishi
Synthesis and triplex-forming ability of 2',4'-BNAs bearing imidazoles as a nucleobase.
Chemical & pharmaceutical bulletin 2005;53(7):843-6.
2005: Satoshi Obika; Akiko Hiroto; Osamu Nakagawa; Takeshi Imanishi
Promotion of stable triplex formation by partial incorporation of 2',5'-phosphodiester linkages into triplex-forming oligonucleotides.
Chemical communications (Cambridge, England) 2005;(22):2793-5.
2005: Satoshi Obika; Mitsuaki Sekiguchi; Roongjang Somjing; Takeshi Imanishi
Adjustment of the gamma dihedral angle of an oligonucleotide P3'-->N5' phosphoramidate enhances its binding affinity towards complementary strands.
Angewandte Chemie (International ed. in English) 2005;44(13):1944-7.
2005: Naoto Tsuda; Ayumi Matsumoto; Aya Ito; Tomomi Uneda; Atsuhiro Tanabe; Satoshi Obika; Takeshi Imanishi
Antigene-block strategy: effective regulation of gene expression by 2',4'-BNA-modified TFOs with an additional stem-loop structure.
Nucleic acids symposium series (2004) 2005;(49):335-6.
2005: Shiho Fujii; Satoshi Obika; Takeshi Imanishi
Effects of the 2',4'-BNA modification on the sequence specificity of molecular beacons.
Nucleic acids symposium series (2004) 2005;(49):211-2.
2005: Sachiko Matsugu; Hidenori Inohara; Satoshi Obika; Takeshi Imanishi
Synthesis and triplex-forming properties of 2',4'-BNA derivatives bearing pyridines as an unnatural nucleobase.
Nucleic acids symposium series (2004) 2005;(49):159-60.
2005: Masaharu Tomizu; Osamu Nakagawa; Satoshi Obika; Takeshi Imanishi
Promotion of acid-mediated cleavage of oligonucleotide P3'->N5' phosphoroamidates by triplex formation: a novel approach to sequence-specific DNA detection.
Nucleic acids symposium series (2004) 2005;(49):157-8.
2005: S M Abdur Rahman; Sayori Seki; Kazushige Utsuki; Satoshi Obika; Kazuyuki Miyashita; Takeshi Imanishi
Synthesis and properties of 2',4'-BNA(NC), a second generation BNA.
Nucleic acids symposium series (2004) 2005;(49):5-6.
2005: Mitsuaki Sekiguchi; Satoshi Obika; Roongjang Somjing; Takeshi Imanishi
Synthesis and properties of a novel bridged nucleic acid analogue, 5'-amino-3',5'-BNA.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):1097-100.
2005: Satoshi Obika; Akiko Hiroto; Osamu Nakagawa; Takeshi Imanishi
Presence of 2',5'-linkages in a homopyrimidine DNA oligonucleotide promotes stable triplex formation under physiological conditions.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):1055-8.
2005: Hidetaka Torigoe; Takuma Katayama; Satoshi Obika; Atushi Maruyama; Takeshi Imanishi
Combination of poly(L-lysine)-graft-dextran copolymer and 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) modification synergistically stabilizes pyrimidine motif triplex at neutral pH.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):635-8.
2004: Satoshi Obika
Development of bridged nucleic acid analogues for antigene technology.
Chemical & pharmaceutical bulletin 2004;52(12):1399-404.
2004: Satoshi Obika
[Bridged nucleic acids (BNAs) as a basic material for genome technology].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2004;124(11):781-90.
2004: Takuma Katayama; Atsushi Maruyama; Satoshi Obika; Takeshi Imanishi; Hidetaka Torigoe
Synergistic stabilization of triplex by combination of comb-type cationic copolymer and 2',4'-BNA.
Nucleic acids symposium series (2004) 2004;(48):139-40.
2004: Hidenori Inohara; Satoshi Obika; Takeshi Imanishi
2',4'-BNA derivatives bearing an unnatural nucleobase: synthesis and application to triplex-forming oligonucleotides.
Nucleic acids symposium series (2004) 2004;(48):63-4.
2004: Mitsuaki Sekiguchi; Satoshi Obika; Roongjang Somjing; Takeshi Imanishi
Synthesis and properties of a novel bridged nucleic acid analogue bearing a P3'-->N5' phosphoroamidate linkage, 5'-amino-3', 5'-BNA.
Nucleic acids symposium series (2004) 2004;(48):7-8.
2003: Satoshi Obika; Osamu Nakagawa; Akiko Hiroto; Yoshiyuki Hari; Takeshi Imanishi
Synthesis and properties of a novel bridged nucleic acid with a P3' --> N5' phosphoramidate linkage, 5'-amino-2',4'-BNA.
Chemical communications (Cambridge, England) 2003;(17):2202-3.
2003: Hidetaka Torigoe; Yoshiyuki Hari; Satoshi Obika; Takeshi Imanishi
Triplex formation involving 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) with 1-isoquinolone base analogue: efficient and selective recognition of C:G interruption.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1571-3.
2003: Hidetaka Torigoe; Yoshiyuki Hari; Satoshi Obika; Takeshi Imanishi
Triplex formation involving 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) with 2-pyridone base analogue: efficient and selective recognition of C:G interruption.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1097-9.
2003: Ping Gao; Xu-Yu Zhou; Yumi Yashiro-ohtani; Yi-Fu Yang; Naotoshi Sugimoto; Shiro Ono; Tsuyoshi Nakanishi; Satoshi Obika; Takeshi Imanishi; Takeshi Egawa; Takashi Nagasawa; Hiromi Fujiwara; Toshiyuki Hamaoka
The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3.
Journal of leukocyte biology 2003;73(2):273-80.
2003: Mitsuaki Sekiguchi; Tomohisa Osaki; Yasuki Harada; Satoshi Obika; Takeshi Imanishi
trans-3',4'-BNAs, novel nucleic acid analogues with an S-type conformation: synthesis and incorporation into oligonucleotides.
Nucleic acids research. Supplement (2001) 2003;(3):111-2.
2003: Osamu Nakagawa; Akiko Hiroto; Satoshi Obika; Takeshi Imanishi
A novel nucleic acid analogue, 3'-amino-2'-deoxy-3',4'-BNA, with an N3'-->P5' phosphoramidate linkage and an S-type conformation.
Nucleic acids research. Supplement (2001) 2003;(3):87-8.
2002: Satoshi Obika; Yoshiyuki Hari; Mitsuaki Sekiguchi; Takeshi Imanishi
Stable oligonucleotide-directed triplex formation at target sites with CG interruptions: strong sequence-specific recognition by 2',4'-bridged nucleic-acid-containing 2-pyridones under physiological conditions.
Chemistry (Weinheim an der Bergstrasse, Germany) 2002;8(20):4796-802.
2002: Takeshi Imanishi; Satoshi Obika
BNAs: novel nucleic acid analogs with a bridged sugar moiety.
Chemical communications (Cambridge, England) 2002;(16):1653-9.
2002: Yi-Fu Yang; Takao Mukai; Ping Gao; Nobuya Yamaguchi; Shiro Ono; Hiroshi Iwaki; Satoshi Obika; Takeshi Imanishi; Takahiro Tsujimura; Toshiyuki Hamaoka; Hiromi Fujiwara
A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses.
European journal of immunology 2002;32(8):2124-32.
2002: Takeshi Imanishi; Satoshi Obika
[Down-regulation of a gene-expression by an antisense BNA oligonucleotide].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(2):85-90.
2002: Yasuhiro Uekusa; Wen-gong Yu; Takao Mukai; Ping Gao; Nobuya Yamaguchi; Masako Murai; Kouji Matsushima; Satoshi Obika; Takeshi Imanishi; Yuji Higashibata; Shintaro Nomura; Yukihiko Kitamura; Hiromi Fujiwara; Toshiyuki Hamaoka
A pivotal role for CC chemokine receptor 5 in T-cell migration to tumor sites induced by interleukin 12 treatment in tumor-bearing mice.
Cancer research 2002;62(13):3751-8.
2002: Kazuyuki Miyashita; Myunji Park; Sayako Adachi; Sayori Seki; Satoshi Obika; Takeshi Imanishi
A 3,4-epoxypiperidine structure as a novel and simple DNA-cleavage unit.
Bioorganic & medicinal chemistry letters 2002;12(7):1075-7.
2002: Hidetaka Torigoe; Yoshiyuki Hari; Satoshi Obika; Takeshi Imanishi
Triplex formation involving 2',4'-BNA with isoquinolone base analogue: efficient and selective recognition of C:G interruption.
Nucleic acids research. Supplement (2001) 2002;(2):183-4.
2002: Yoshiyuki Hari; Tomohisa Osaki; Ken Eguchi; Satoshi Obika; Takeshi Imanishi
Synthesis and properties of oligonucleotides containing novel 2',4'-BNA analogues (2',4'-BNACOC).
Nucleic acids research. Supplement (2001) 2002;(2):147-8.
2002: Hidetaka Torigoe; Shinobu Sato; Ken-ichi Yamashita; Satoshi Obika; Takeshi Imanishi; Shigeori Takenaka
Binding of threading intercalator to nucleic acids: thermodynamic analyses.
Nucleic acids research. Supplement (2001) 2002;(2):55-6.
2002: Satoshi Obika; Osamu Nakagawa; Akiko Hiroto; Yoshiyuki Hari; Takeshi Imanishi
Synthesis and properties of 5'-amino-2',4'-BNA modified oligonucleotides with P3'-->N5' phosphoramidate linkages.
Nucleic acids research. Supplement (2001) 2002;(2):25-6.
2001: Satoshi Obika; M Onoda; K Morita; J Andoh; M Koizumi; Takeshi Imanishi
3'-amino-2',4'-BNA: novel bridged nucleic acids having an N3'-->P5' phosphoramidate linkage.
Chemical communications (Cambridge, England) 2001;(19):1992-3.
2001: Satoshi Obika; Tomomi Uneda; T Sugimoto; D Nanbu; Takashi Minami; Takefumi Doi; Takeshi Imanishi
2'-O,4'-C-Methylene bridged nucleic acid (2',4'-BNA): synthesis and triplex-forming properties.
Bioorganic & medicinal chemistry 2001;9(4):1001-11.
2001: Satoshi Obika; W Yu; Atsuko Shimoyama; Tomomi Uneda; K Miyashita; Takefumi Doi; Takeshi Imanishi
Symmetrical cationic triglycerides: an efficient synthesis and application to gene transfer.
Bioorganic & medicinal chemistry 2001;9(2):245-54.
2001: Hidetaka Torigoe; Yoshiyuki Hari; Satoshi Obika; Takeshi Imanishi
Triplex formation involving 2',4'-BNA with 2-pyridone base analogue: efficient and selective recognition of C:G interruption.
Nucleic acids research. Supplement (2001) 2001;(1):281-2.
2001: Satoshi Obika; Yoshiyuki Hari; Hidenori Inohara; Takeshi Imanishi
2',4'-BNA bearing unnatural nucleobases: toward the expansion of the target sequence of double-stranded DNA in triplex formation.
Nucleic acids research. Supplement (2001) 2001;(1):171-2.
2001: Satoshi Obika; R Hemamayi; T Masuda; T Sugimoto; S Nakagawa; T Mayumi; Takeshi Imanishi
Inhibition of ICAM-1 gene expression by antisense 2',4'-BNA oligonucleotides.
Nucleic acids research. Supplement (2001) 2001;(1):145-6.
2000: Satoshi Obika
[Syntheses and properties of conformationally restrained nucleosides and oligonucleotides analogues].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2000;120(2):147-58.
2000: Satoshi Obika; Yoshiyuki Hari; Mitsuaki Sekiguchi; Takeshi Imanishi
Synthesis and triplex forming ability of conformationally locked oligonucleotides containing unnatural nucleobases: efficient recognition of a C.G interruption.
Nucleic acids symposium series 2000;(44):131-2.
1999: W Yu; Atsuko Shimoyama; Tomomi Uneda; Satoshi Obika; K Miyashita; Takefumi Doi; Takeshi Imanishi
Gene transfer mediated by YKS-220 cationic particles: convenient and efficient gene delivery reagent.
Journal of biochemistry 1999;125(6):1034-8.
1999: Satoshi Obika; K Morio; Yoshiyuki Hari; Takeshi Imanishi
Preparation and properties of 2',5'-linked oligonucleotide analogues containing 3'-O,4'-C-methyleneribonucleosides.
Bioorganic & medicinal chemistry letters 1999;9(4):515-8.
1999: Satoshi Obika; W Yu; Atsuko Shimoyama; Tomomi Uneda; Takashi Minami; K Miyashita; Takefumi Doi; Takeshi Imanishi
Properties of cationic liposomes composed of cationic lipid YKS-220 having an ester linkage: adequate stability, high transfection efficiency, and low cytotoxicity.
Biological & pharmaceutical bulletin 1999;22(2):187-90.