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Leslie Benet

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
29
Christians, Uwe
27
Lin, Emil
17
Jacobsen, Wolfgang
11
Frassetto, Lynda
11
Serkova, Natalie
9
Grillo, Mark
8
Cummins, Carolyn
8
Li, Chunze
8
Williams, Roger
7
Wacher, Vincent
6
Wu, Chi-Yuan
6
Tomlanovich, Stephen
6
Hausen, Bernard
6
Huang, Yong
5
Leibfritz, Dieter

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Publications

TOP 3
de Souza Jacqueline; Benet Leslie Z; Huang Yong; Storpirtis Sílvia
Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers.
Shugarts Sarah; Benet Leslie Z
The role of transporters in the pharmacokinetics of orally administered drugs.
Benet L Z
A Holy Grail of clinical pharmacology: prediction of drug pharmacokinetics and pharmacodynamics in the individual patient.

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All Publications

2009: de Souza Jacqueline; Benet Leslie Z; Huang Yong; Storpirtis Sílvia
Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers.
Journal of pharmaceutical sciences 2009;98(11):4413-9.
2009: Shugarts Sarah; Benet Leslie Z
The role of transporters in the pharmacokinetics of orally administered drugs.
Pharmaceutical research 2009;26(9):2039-54.
2009: Benet L Z
A Holy Grail of clinical pharmacology: prediction of drug pharmacokinetics and pharmacodynamics in the individual patient.
Clinical pharmacology and therapeutics 2009;86(2):133-4.
2009: Grover Anita; Benet Leslie Z
Effects of drug transporters on volume of distribution.
The AAPS journal 2009;11(2):250-61.
2009: Frymoyer Adam; Hersh Adam L; Benet Leslie Z; Guglielmo B Joseph
Current recommended dosing of vancomycin for children with invasive methicillin-resistant Staphylococcus aureus infections is inadequate.
The Pediatric infectious disease journal 2009;28(5):398-402.
2008: Sahin Selma; Benet Leslie Z
The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms.
Pharmaceutical research 2008;25(12):2869-77.
2008: Grillo Mark P; Hua Fengmei; March Kristi L; Benet Leslie Z; Knutson Charles G; Ware Joseph A
Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat.
Chemical research in toxicology 2008;21(10):1933-8.
2008: Li Chunze; Grillo Mark P; Badagnani Ilaria; Fife Kimberly L; Benet Leslie Z
Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(4):682-7.
2008: Benet Leslie Z; Amidon Gordon L; Barends Dirk M; Lennernäs Hans; Polli James E; Shah Vinod P; Stavchansky Salomon A; Yu Lawrence X
The use of BDDCS in classifying the permeability of marketed drugs.
Pharmaceutical research 2008;25(3):483-8.
2008: Custodio Joseph M; Wu Chi-Yuan; Benet Leslie Z
Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption.
Advanced drug delivery reviews 2008;60(6):717-33.
2008: Roland M E; Barin B; Carlson L; Frassetto L A; Terrault N A; Hirose R; Freise C E; Benet L Z; Ascher N L; Roberts J P; Murphy B; Keller M J; Olthoff K M; Blumberg E A; Brayman K L; Bartlett S T; Davis C E; McCune J M; Bredt B M; Stablein D M; Stock P G
HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(2):355-65.
2008: Monera Tsitsi G; Wolfe Alan R; Maponga Charles C; Benet Leslie Z; Guglielmo Joseph
Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4.
Journal of infection in developing countries 2008;2(5):379-83.
2007: Frassetto L A; Browne M; Cheng A; Wolfe A R; Roland M E; Stock P G; Carlson L; Benet L Z
Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(12):2816-20.
2007: Boernsen K Olaf; Egge-Jacobsen Wolfgang; Inverardi Bruno; Strom Tobin; Streit Frank; Schiebel Hans-Martin; Benet Leslie Z; Christians Uwe
Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus.
Journal of mass spectrometry : JMS 2007;42(6):793-802.
2007: Olsen Jørgen; Li Chunze; Skonberg Christian; Bjørnsdottir Inga; Sidenius Ulrik; Benet Leslie Z; Hansen Steen Honoré
Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(5):758-64.
2007: Benet L Z
Review and critique of the Institute of Medicine report "the future of drug safety".
Clinical pharmacology and therapeutics 2007;81(2):158-61.
2007: Lau Y Y; Huang Y; Frassetto L; Benet L Z
effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers.
Clinical pharmacology and therapeutics 2007;81(2):194-204.
2006: Lam Justine L; Shugarts Sarah B; Okochi Hideaki; Benet Leslie Z
Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism.
The Journal of pharmacology and experimental therapeutics 2006;319(2):864-70.
2006: Lam Justine L; Okochi Hideaki; Huang Yong; Benet Leslie Z
In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(8):1336-44.
2006: Lau Yvonne Y; Okochi Hideaki; Huang Yong; Benet Leslie Z
Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(7):1175-81.
2006: Huang Yong; Okochi Hideaki; May Barnaby C H; Legname Giuseppe; Prusiner Stanley B; Benet Leslie Z; Guglielmo B Joseph; Lin Emil T
Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(7):1136-44.
2006: Lau Yvonne Y; Okochi Hideaki; Huang Yong; Benet Leslie Z
Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems.
The Journal of pharmacology and experimental therapeutics 2006;316(2):762-71.
2006: Sun Hong; Frassetto Lynda; Benet Leslie Z
Effects of renal failure on drug transport and metabolism.
Pharmacology & therapeutics 2006;109(1-2):1-11.
2006: Huang Yong; Sun Hong; Frassetto Lynda; Benet Leslie Z; Lin Emil T
Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma.
Rapid communications in mass spectrometry : RCM 2006;20(10):1611-4.
2005: Olsen Jørgen; Li Chunze; Bjørnsdottir Inga; Sidenius Ulrik; Hansen Steen Honoré; Benet Leslie Z
In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats.
Chemical research in toxicology 2005;18(11):1729-36.
2005: Chang Jae H; Benet Leslie Z
Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells.
Molecular pharmaceutics 2005;2(5):428-34.
2005: Wetmore James B; Benet Leslie Z; Kleinstuck Danja; Frassetto Lynda
Effects of short-term alendronate on bone mineral density in haemodialysis patients.
Nephrology (Carlton, Vic.) 2005;10(4):393-9.
2005: Frassetto Lynda; Baluom Muhammad; Jacobsen Wolfgang; Christians Uwe; Roland Michelle E; Stock Peter G; Carlson Laurie; Benet Leslie Z
Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients.
Transplantation 2005;80(1):13-7.
2005: Benet Leslie Z
There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found.
Molecular interventions 2005;5(2):79-83.
2005: Putnam Wendy S; Woo Jonathan M; Huang Yong; Benet Leslie Z
Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics.
Journal of clinical pharmacology 2005;45(4):411-21.
2005: Mohri Kiminori; Okada Kenji; Benet Leslie Z
Stereoselective taurine conjugation of (R)-benoxaprofen enantiomer in rats: in vivo and in vitro studies using rat hepatic mitochondria and microsomes.
Pharmaceutical research 2005;22(1):79-85.
2005: Wu Chi-Yuan; Benet Leslie Z
Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system.
Pharmaceutical research 2005;22(1):11-23.
2004: Lam Justine L; Benet Leslie Z
Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(11):1311-6.
2004: Sun Hong; Huang Yong; Frassetto Lynda; Benet Leslie Z
Effects of uremic toxins on hepatic uptake and metabolism of erythromycin.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(11):1239-46.
2004: Ikeno Fumiaki; Lyons Jennifer; Kaneda Hideaki; Baluom Muhammad; Benet Leslie Z; Rezaee Mehrdad
Novel percutaneous adventitial drug delivery system for regional vascular treatment.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2004;63(2):222-30.
2004: Egge-Jacobsen Wolfgang; Unger Matthias; Niemann Claus U; Baluom Muhammad; Hirai Sumiko; Benet Leslie Z; Christians Uwe
Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors.
Therapeutic drug monitoring 2004;26(5):546-62.
2004: Christians Uwe; Gottschalk Sven; Miljus Jelena; Hainz Carsten; Benet Leslie Z; Leibfritz Dieter; Serkova Natalie
Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors.
British journal of pharmacology 2004;143(3):388-96.
2004: Kim Winnie Y; Benet Leslie Z
P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro.
Pharmaceutical research 2004;21(7):1284-93.
2004: Benet L Z; Cummins C L; Wu C Y
Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.
International journal of pharmaceutics 2004;277(1-2):3-9.
2004: Frassetto Lynda A; Benet Leslie Z
Pharmacogenomics and transplantation: where are we?
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(6):843.
2004: Serkova Natalie J; Christians Uwe; Benet Leslie Z
Biochemical mechanisms of cyclosporine neurotoxicity.
Molecular interventions 2004;4(2):97-107.
2004: Lau Yvonne Y; Wu Chi-Yuan; Okochi Hideaki; Benet Leslie Z
Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay.
The Journal of pharmacology and experimental therapeutics 2004;308(3):1040-5.
2004: Cummins Carolyn L; Jacobsen Wolfgang; Christians Uwe; Benet Leslie Z
CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.
The Journal of pharmacology and experimental therapeutics 2004;308(1):143-55.
2003: Wu Chi-Yuan; Benet Leslie Z
Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(11):1292-5.
2003: Li Chunze; Olurinde Mobolaji O; Hodges Laura M; Grillo Mark P; Benet Leslie Z
Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(6):727-30.
2003: Cummins Carolyn L; Salphati Laurent; Reid Michael J; Benet Leslie Z
In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model.
The Journal of pharmacology and experimental therapeutics 2003;305(1):306-14.
2003: Li Chunze; Grillo Mark P; Benet Leslie Z
In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat.
The Journal of pharmacology and experimental therapeutics 2003;305(1):250-6.
2003: Li Chunze; Grillo Mark P; Benet Leslie Z
In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester.
Toxicology and applied pharmacology 2003;187(2):101-9.
2003: Hebert Mary F; Wacher Vincent J; Roberts John P; Benet Leslie Z
Pharmacokinetics of cyclosporine pre- and post-liver transplantation.
Journal of clinical pharmacology 2003;43(1):38-42.
2003: Frassetto Lynda; Thai Thien; Aggarwal Anjana M; Bucher Patricia; Jacobsen Wolfgang; Christians Uwe; Benet Leslie Z; Floren Leslie C
Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects.
Drug metabolism and pharmacokinetics 2003;18(2):114-20.
2002: Unger Matthias; Holzgrabe Ulrike; Jacobsen Wolfgang; Cummins Carolyn; Benet Leslie Z
Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).
Planta medica 2002;68(12):1055-8.
2002: Putnam Wendy S; Ramanathan Srinivasan; Pan Lin; Takahashi Lori H; Benet Leslie Z
Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells.
Journal of pharmaceutical sciences 2002;91(12):2622-35.
2002: Li Chunze; Benet Leslie Z; Grillo Mark P
Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes.
Chemical research in toxicology 2002;15(11):1480-7.
2002: Cummins Carolyn L; Wu Chi-Yuan; Benet Leslie Z
Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein.
Clinical pharmacology and therapeutics 2002;72(5):474-89.
2002: Li Chunze; Benet Leslie Z; Grillo Mark P
Studies on the chemical reactivity of 2-phenylpropionic acid 1-O-acyl glucuronide and S-acyl-CoA thioester metabolites.
Chemical research in toxicology 2002;15(10):1309-17.
2002: Niemann Claus U; Saeed Maythem; Akbari Haydar; Jacobsen Wolfgang; Benet Leslie Z; Christians Uwe; Serkova Natalie
Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine.
The Journal of pharmacology and experimental therapeutics 2002;302(3):1123-8.
2002: Susanto Miki; Benet Leslie Z
Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport?
Pharmaceutical research 2002;19(4):457-62.
2002: Flanagan Shawn D; Takahashi Lpori H; Liu Xiaoli; Benet Leslie Z
Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells.
Journal of pharmaceutical sciences 2002;91(4):1169-77.
2002: Benet Leslie Z; Hoener Betty-ann
Changes in plasma protein binding have little clinical relevance.
Clinical pharmacology and therapeutics 2002;71(3):115-21.
2002: Serkova Natalie; Donohoe Paul; Gottschalk Sven; Hainz Carsten; Niemann Claus U; Bickler Philip E; Litt Lawrence; Benet Leslie Z; Leibfritz Dieter; Christians Uwe
Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(3):342-52.
2002: Parasrampuria Dolly A; Lantz Marianne V; Birnbaum Jytte L; Vincenti Flavio G; Benet Leslie Z
Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation.
Journal of clinical pharmacology 2002;42(3):304-11.
2002: Cummins Carolyn L; Jacobsen Wolfgang; Benet Leslie Z
Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.
The Journal of pharmacology and experimental therapeutics 2002;300(3):1036-45.
2002: Unger Matthias; Jacobsen Wolfgang; Holzgrabe Ulrike; Benet Leslie Z
Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;767(2):245-53.
2002: Putnam Wendy S; Pan Lin; Tsutsui Ken; Takahashi Lori; Benet Leslie Z
Comparison of bidirectional cephalexin transport across MDCK and caco-2 cell monolayers: interactions with peptide transporters.
Pharmaceutical research 2002;19(1):27-33.
2002: Grillo Mark P; Benet Leslie Z
Studies on the reactivity of clofibryl-S-acyl-CoA thioester with glutathione in vitro.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(1):55-62.
2002: Christians Uwe; Jacobsen Wolfgang; Benet Leslie Z; Lampen Alfonso
Mechanisms of clinically relevant drug interactions associated with tacrolimus.
Clinical pharmacokinetics 2002;41(11):813-51.
2002: Flanagan Shawn D; Cummins Carolyn L; Susanto Miki; Liu Xiaoli; Takahashi Lori H; Benet Leslie Z
Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2).
Pharmacology 2002;64(3):126-34.
2001: Benet L Z; Cummins C L
The drug efflux-metabolism alliance: biochemical aspects.
Advanced drug delivery reviews 2001;50 Suppl 1():S3-11.
2001: Grillo M P; Chiellini G; Tonelli M; Benet L Z
Effect of alpha-fluorination of valproic acid on valproyl-S-acyl-CoA formation in vivo in rats.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(9):1210-5.
2001: Cummins C L; Mangravite L M; Benet L Z
Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.
Pharmaceutical research 2001;18(8):1102-9.
2001: Grillo M P; Benet L Z
Interaction of gamma-glutamyltranspeptidase with clofibryl-S-acyl-glutathione in vitro and in vivo in rat.
Chemical research in toxicology 2001;14(8):1033-40.
2001: Serkova N; Jacobsen W; Niemann C U; Litt L; Benet L Z; Leibfritz D; Christians U
Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.
British journal of pharmacology 2001;133(6):875-85.
2001: Kuhn B; Jacobsen W; Christians U; Benet L Z; Kollman P A
Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations.
Journal of medicinal chemistry 2001;44(12):2027-34.
2001: Jacobsen W; Serkova N; Hausen B; Morris R E; Benet L Z; Christians U
Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD.
Transplantation proceedings 2001;33(1-2):514-5.
2001: Parasrampuria D A; Lantz M V; Benet L Z
A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function.
Pharmaceutical research 2001;18(1):39-44.
2001: Mancinelli L M; Frassetto L; Floren L C; Dressler D; Carrier S; Bekersky I; Benet L Z; Christians U
The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups.
Clinical pharmacology and therapeutics 2001;69(1):24-31.
2000: Jacobsen W; Kuhn B; Soldner A; Kirchner G; Sewing K F; Kollman P A; Benet L Z; Christians U
Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(11):1369-78.
2000: Jacobsen W; Christians U; Benet L Z
In vitro evaluation of the disposition of A novel cysteine protease inhibitor.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(11):1343-51.
2000: Christians U; Jacobsen W; Serkova N; Benet L Z; Vidal C; Sewing K F; Manns M P; Kirchner G I
Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants.
Journal of chromatography. B, Biomedical sciences and applications 2000;748(1):41-53.
2000: Serkova N; Hausen B; Berry G J; Jacobsen W; Benet L Z; Morris R E; Christians U
Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine.
The Journal of pharmacology and experimental therapeutics 2000;294(1):323-32.
2000: Christians U; First M R; Benet L Z
Recommendations for bioequivalence testing of cyclosporine generics revisited.
Therapeutic drug monitoring 2000;22(3):330-45.
2000: Soldner A; Benet L Z; Mutschler E; Christians U
Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers.
British journal of pharmacology 2000;129(6):1235-43.
2000: Serkova N; Litt L; Leibfritz D; Hausen B; Morris R E; James T L; Benet L Z; Christians U
The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates.
British journal of pharmacology 2000;129(3):485-92.
2000: Hausen B; Ikonen T; Briffa N; Berry G J; Christians U; Robbins R C; Hook L; Serkova N; Benet L Z; Schuler W; Morris R E
Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability.
Transplantation 2000;69(1):76-86.
1999: Benet L Z; Izumi T; Zhang Y; Silverman J A; Wacher V J
Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 1999;62(1-2):25-31.
1999: Jacobsen W; Kirchner G; Hallensleben K; Mancinelli L; Deters M; Hackbarth I; Baner K; Benet L Z; Sewing K F; Christians U
Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin.
The Journal of pharmacology and experimental therapeutics 1999;291(1):131-9.
1999: Mizuma T; McDonagh A F; Lin E T; Benet L Z
Photoinduced covalent binding of frusemide and frusemide glucuronide to human serum albumin.
British journal of clinical pharmacology 1999;48(1):79-87.
1999: Benet L Z
Relevance of pharmacokinetics in narrow therapeutic index drugs.
Transplantation proceedings 1999;31(3):1642-4; discussion 1675-84.
1999: Benet L Z
Understanding bioequivalence testing.
Transplantation proceedings 1999;31(3A Suppl):7S-9S.
1999: Serkova N; Litt L; James T L; Sadée W; Leibfritz D; Benet L Z; Christians U
Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy.
The Journal of pharmacology and experimental therapeutics 1999;289(2):800-6.
1999: Soldner A; Christians U; Susanto M; Wacher V J; Silverman J A; Benet L Z
Grapefruit juice activates P-glycoprotein-mediated drug transport.
Pharmaceutical research 1999;16(4):478-85.
1999: Hausen B; Boeke K; Berry G J; Segarra I; Benet L Z; Christians U; Morris R E
Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: potentiation of immunosuppressive efficacy and improvement of tolerability of staggered versus simultaneous treatment.
Transplantation 1999;67(7):956-62.
1999: Mizuma T; Benet L Z; Lin E T
Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible binding and irreversible binding of a 1-O-acyl glucuronide metabolite.
Biopharmaceutics & drug disposition 1999;20(3):131-6.
1999: Zhang Y; Guo X; Lin E T; Benet L Z
In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes.
Pharmacology 1999;58(3):147-59.
1999: Salphati L; Benet L Z
Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(2):171-85.
1999: Flanagan S D; Benet L Z
Net secretion of furosemide is subject to indomethacin inhibition, as observed in Caco-2 monolayers and excised rat jejunum.
Pharmaceutical research 1999;16(2):221-24.
1999: Jacobsen W; Kirchner G; Hallensleben K; Mancinelli L; Deters M; Hackbarth I; Benet L Z; Sewing K F; Christians U
Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(2):173-9.
1998: Tsunoda S M; Harris R Z; Mroczkowski P J; Benet L Z
Preliminary evaluation of progestins as inducers of cytochrome P450 3A4 activity in postmenopausal women.
Journal of clinical pharmacology 1998;38(12):1137-43.
1998: Segarra I; Brazelton T R; Guterman N; Hausen B; Jacobsen W; Morris R E; Benet L Z; Christians U
Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin.
Journal of chromatography. B, Biomedical sciences and applications 1998;720(1-2):179-87.
1998: Wacher V J; Silverman J A; Zhang Y; Benet L Z
Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.
Journal of pharmaceutical sciences 1998;87(11):1322-30.
1998: Mizuma T; Benet L Z; Lin E T
High-performance liquid chromatographic determination and identification of acyl migration and photodegradation products of furosemide 1-O-acyl glucuronide.
Journal of chromatography. B, Biomedical sciences and applications 1998;718(1):153-62.
1998: Zhang Y; Benet L Z
Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers.
Pharmaceutical research 1998;15(10):1520-4.
1998: Zhang Y; Hsieh Y; Izumi T; Lin E T; Benet L Z
Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats.
The Journal of pharmacology and experimental therapeutics 1998;287(1):246-52.
1998: Benet L Z
Impact of intraindividual variability of drugs on therapeutic outcomes: lessons from outside transplantation.
Transplantation proceedings 1998;30(5):1650-1.
1998: Salphati L; Benet L Z
Effects of ketoconazole on digoxin absorption and disposition in rat.
Pharmacology 1998;56(6):308-13.
1998: Lampen A; Zhang Y; Hackbarth I; Benet L Z; Sewing K F; Christians U
Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1104-12.
1998: Zhang Y; Guo X; Lin E T; Benet L Z
Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(4):360-6.
1998: Mohri K; Okada K; Benet L Z
Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(4):332-7.
1998: Jang G R; Benet L Z
Antiprogestin-mediated inactivation of cytochrome P450 3A4.
Pharmacology 1998;56(3):150-7.
1998: Qiu Y; Burlingame A L; Benet L Z
Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(3):246-56.
1998: Mizuma T; Benet L Z; Lin E T
Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized amberiite XAD-2 and its application to other 1-O-acyl-glucuronides.
Preparative biochemistry & biotechnology 1998;28(1):37-47.
1998: Salphati L; Benet L Z
Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.
Biochemical pharmacology 1998;55(4):387-95.
1997: Jang G R; Benet L Z
Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use.
Journal of pharmacokinetics and biopharmaceutics 1997;25(6):647-72.
1997: Jang G R; Benet L Z
Cytochrome P4503A4-mediated N-demethylation of the antiprogestins lilopristone and onapristone.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(10):1119-22.
1997: Floren L C; Bekersky I; Benet L Z; Mekki Q; Dressler D; Lee J W; Roberts J P; Hebert M F
Tacrolimus oral bioavailability doubles with coadministration of ketoconazole.
Clinical pharmacology and therapeutics 1997;62(1):41-9.
1997: Yuan R; Sumi M; Benet L Z
Investigation of aortic CYP3A bioactivation of nitroglycerin in vivo.
The Journal of pharmacology and experimental therapeutics 1997;281(3):1499-505.
1996: Sambol N C; Chiang J; O'Conner M; Liu C Y; Lin E T; Goodman A M; Benet L Z; Karam J H
Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus.
Journal of clinical pharmacology 1996;36(11):1012-21.
1996: Sambol N C; Brookes L G; Chiang J; Goodman A M; Lin E T; Liu C Y; Benet L Z
Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man.
British journal of clinical pharmacology 1996;42(4):510-2.
1996: Jang G R; Wrighton S A; Benet L Z
Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes.
Biochemical pharmacology 1996;52(5):753-61.
1996: Kenkare S R; Benet L Z
Tolerance to nitroglycerin in rabbit aorta. Investigating the involvement of the mu isozyme of glutathione S-transferases.
Biochemical pharmacology 1996;51(10):1357-63.
1996: Berg-Candolfi M; Candolfi E; Benet L Z
Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(4):381-94.
1996: Harris R Z; Tsunoda S M; Mroczkowski P; Wong H; Benet L Z
The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics.
Clinical pharmacology and therapeutics 1996;59(4):429-35.
1996: Jaeger W; Benet L Z; Bornheim L M
Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(3):275-84.
1996: Chang T; Benet L Z; Hebert M F
The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers.
Clinical pharmacology and therapeutics 1996;59(3):297-303.
1995: Sambol N C; Chiang J; Lin E T; Goodman A M; Liu C Y; Benet L Z; Cogan M G
Kidney function and age are both predictors of pharmacokinetics of metformin.
Journal of clinical pharmacology 1995;35(11):1094-102.
1995: Wu C Y; Benet L Z; Hebert M F; Gupta S K; Rowland M; Gomez D Y; Wacher V J
Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine.
Clinical pharmacology and therapeutics 1995;58(5):492-7.
1995: Iwaki M; Bischer A; Nguyen A C; McDonagh A F; Benet L Z
Stereoselective disposition of naproxen glucuronide in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(10):1099-103.
1995: d'Uscio C H; Aweeka F T; Prueksaritanont T; Tomlanovich S J; Gupta S K; Lantz M V; Gambertoglio J G; Garovoy M R; Benet L Z
Immunopharmacodynamic studies of cyclosporine in patients awaiting renal transplantation.
Journal of clinical pharmacology 1995;35(10):967-73.
1995: Zia-Amirhosseini P; Ding A; Burlingame A L; McDonagh A F; Benet L Z
Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac.
The Biochemical journal 1995;311 ( Pt 2)():431-5.
1995: Bischer A; Iwaki M; Zia-Amirhosseini P; Benet L Z
Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(9):900-3.
1995: Bischer A; Zia-Amirhosseini P; Iwaki M; McDonagh A F; Benet L Z
Stereoselective binding properties of naproxen glucuronide diastereomers to proteins.
Journal of pharmacokinetics and biopharmaceutics 1995;23(4):379-95.
1995: Harris R Z; Benet L Z; Schwartz J B
Gender effects in pharmacokinetics and pharmacodynamics.
Drugs 1995;50(2):222-39.
1995: Gomez D Y; Wacher V J; Tomlanovich S J; Hebert M F; Benet L Z
The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine.
Clinical pharmacology and therapeutics 1995;58(1):15-9.
1995: Wacher V J; Wu C Y; Benet L Z
Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.
Molecular carcinogenesis 1995;13(3):129-34.
1995: Benet L Z; Goyan J E
Bioequivalence and narrow therapeutic index drugs.
Pharmacotherapy 1995;15(4):433-40.
1995: Wacher V J; Liu T; Roberts J P; Ascher N L; Benet L Z
Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals.
Biopharmaceutics & drug disposition 1995;16(4):303-12.
1995: Haj-Yehia A I; Benet L Z
Dissociation of tissue thiols content from nitroglycerin-induced cyclic-3',5'-guanosine monophosphate and the state of tolerance: in vivo experiments in rats.
The Journal of pharmacology and experimental therapeutics 1995;273(1):94-100.
1995: Haj-Yehia A I; Benet L Z
2-(4-N-maleimidophenyl)-6-methoxybenzofuran: a superior derivatizing agent for fluorimetric determination of aliphatic thiols by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications 1995;666(1):45-53.
1995: Ding A; Zia-Amirhosseini P; McDonagh A F; Burlingame A L; Benet L Z
Reactivity of tolmetin glucuronide with human serum albumin. Identification of binding sites and mechanisms of reaction by tandem mass spectrometry.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(3):369-76.
1995: Benet L Z; Zia-Amirhosseini P
Basic principles of pharmacokinetics.
Toxicologic pathology 1995;23(2):115-23.
1995: Haj-Yehia A I; Benet L Z
Determination of aliphatic thiols by fluorometric high-performance liquid chromatography after precolumn derivatization with 2-(4-N-maleimidophenyl)-6-methylbenzothiazole.
Pharmaceutical research 1995;12(1):155-60.
1994: Kenkare S R; Han C; Benet L Z
Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase.
Biochemical pharmacology 1994;48(12):2231-5.
1994: Ojingwa J C; Spahn-Langguth H; Benet L Z
Irreversible binding of tolmetin to macromolecules via its glucuronide: binding to blood constituents, tissue homogenates and subcellular fractions in vitro.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(6):495-506.
1994: Perotti B Y; Prueksaritanont T; Benet L Z
HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes.
Pharmaceutical research 1994;11(6):844-7.
1994: Han C; Jung P; Sanders S W; Lin E T; Benet L Z
Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration.
Biopharmaceutics & drug disposition 1994;15(2):179-83.
1994: Ojingwa J C; Spahn-Langguth H; Benet L Z
Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma.
Journal of pharmacokinetics and biopharmaceutics 1994;22(1):19-40.
1994: Zia-Amirhosseini P; Ojingwa J C; Spahn-Langguth H; McDonagh A F; Benet L Z
Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing.
Clinical pharmacology and therapeutics 1994;55(1):21-7.
1994: Aweeka F T; Tomlanovich S J; Prueksaritanont T; Gupta S K; Benet L Z
Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients.
Journal of clinical pharmacology 1994;34(1):60-7.
1994: Perotti B Y; Okudaira N; Prueksaritanont T; Benet L Z
FK 506 metabolism in male and female rat liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(1):85-9.
1994: Zia-Amirhosseini P; Spahn-Langguth H; Benet L Z
Bioactivation by glucuronide-conjugate formation.
Advances in pharmacology (San Diego, Calif.) 1994;27():385-97.
1993: Munafo A; Hyneck M L; Benet L Z
Pharmacokinetics and irreversible binding of tolmetin and its glucuronic acid esters in the elderly.
Pharmacology 1993;47(5):309-17.
1993: Lee F W; Salmonson T; Benet L Z
Pharmacokinetics and pharmacodynamics of nitroglycerin and its dinitrate metabolites in conscious dogs: intravenous infusion studies.
Journal of pharmacokinetics and biopharmaceutics 1993;21(5):533-50.
1993: Gumbleton M; Benet L Z
Simultaneous pharmacodynamic modeling of the non-steady-state effects of three oral doses of 1,3-glyceryl dinitrate upon blood pressure in healthy volunteers.
Journal of pharmacokinetics and biopharmaceutics 1993;21(5):515-32.
1993: Kenkare S R; Benet L Z
Effect of ethacrynic acid, a glutathione-S-transferase inhibitor, on nitroglycerin-mediated cGMP elevation and vasorelaxation of rabbit aortic strips.
Biochemical pharmacology 1993;46(2):279-84.
1993: Prueksaritanont T; Correia M A; Rettie A E; Swinney D C; Thomas P E; Benet L Z
Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(4):730-7.
1993: Ding A; Ojingwa J C; McDonagh A F; Burlingame A L; Benet L Z
Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):3797-801.
1993: Lee F W; Hu J; Metzler C H; Benet L Z
Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: a preliminary report.
Journal of pharmacokinetics and biopharmaceutics 1993;21(2):163-73.
1993: Benet L Z
New techniques in drug metabolism and clinical pharmacology/pharmacokinetics.
American biotechnology laboratory 1993;11(2):44-7.
1993: Benet L Z; Spahn-Langguth H; Iwakawa S; Volland C; Mizuma T; Mayer S; Mutschler E; Lin E T
Predictability of the covalent binding of acidic drugs in man.
Life sciences 1993;53(8):PL141-6.
1992: Lau D T; Chan E K; Benet L Z
Glutathione S-transferase-mediated metabolism of glyceryl trinitrate in subcellular fractions of bovine coronary arteries.
Pharmaceutical research 1992;9(11):1460-4.
1992: Hebert M F; Roberts J P; Prueksaritanont T; Benet L Z
Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction.
Clinical pharmacology and therapeutics 1992;52(5):453-7.
1992: Cahalan M K; Hashimoto Y; Aizawa K; Verotta D; Ionescu P; Balea M; Eger E I; Benet L Z; Ehrenfeld W K; Goldstone J
Elderly, conscious patients have an accentuated hypotensive response to nitroglycerin.
Anesthesiology 1992;77(4):646-55.
1992: Han C; Gumbleton M; Lau D T; Benet L Z
Improved gas chromatographic assay for the simultaneous determination of nitroglycerin and its mono- and dinitrate metabolites.
Journal of chromatography 1992;579(2):237-45.
1992: Prueksaritanont T; Hoener B A; Benet L Z
Effects of low-density lipoprotein and ethinyl estradiol on cyclosporine metabolism in isolated rat liver perfusions.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(4):547-52.
1992: Lau D T; Benet L Z
Effects of sulfobromophthalein and ethacrynic acid on glyceryl trinitrate relaxation.
Biochemical pharmacology 1992;43(10):2247-54.
1992: Prueksaritanont T; Koike M; Hoener B A; Benet L Z
Transport and metabolism of cyclosporine in isolated rat hepatocytes. The effects of lipids.
Biochemical pharmacology 1992;43(9):1997-2006.
1992: Higo N; Hinz R S; Lau D T; Benet L Z; Guy R H
Cutaneous metabolism of nitroglycerin in vitro. II. Effects of skin condition and penetration enhancement.
Pharmaceutical research 1992;9(3):303-6.
1992: Higo N; Hinz R S; Lau D T; Benet L Z; Guy R H
Cutaneous metabolism of nitroglycerin in vitro. I. Homogenized versus intact skin.
Pharmaceutical research 1992;9(2):187-90.
1992: Hale V G; Benet L Z
The interconversion of prednisone and prednisolone in human and rabbit organs in vitro is a function of tissue integrity.
Pharmacology 1992;44(5):273-82.
1992: Spahn-Langguth H; Benet L Z
Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?
Drug metabolism reviews 1992;24(1):5-47.
1991: Volland C; Sun H; Dammeyer J; Benet L Z
Stereoselective degradation of the fenoprofen acyl glucuronide enantiomers and irreversible binding to plasma protein.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(6):1080-6.
1991: Kikkoji T; Gumbleton M; Higo N; Guy R H; Benet L Z
Percutaneous penetration kinetics of nitroglycerin and its dinitrate metabolites across hairless mouse skin in vitro.
Pharmaceutical research 1991;8(10):1231-7.
1991: Iwakawa S; Spahn H; Benet L Z; Lin E T
Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(5):853-7.
1991: Hammarlund-Udenaes M; Benet L Z
Prednisone and prednisolone interconversion in the rabbit utilizing unbound concentrations.
Biopharmaceutics & drug disposition 1991;12(6):467-77.
1991: Nakashima E; Lau D T; Benet L Z
Variable glyceryl dinitrate formation following infusions of glyceryl trinitrate at different vascular sites in the rat.
Pharmaceutical research 1991;8(7):877-82.
1991: Williams R L; Thakker K M; John V; Lin E T; Liang-Gee W; Benet L Z
Nitroglycerin absorption from transdermal systems: formulation effects and metabolite concentrations.
Pharmaceutical research 1991;8(6):744-9.
1991: Iwakawa S; He X W; Hashimoto S; Volland C; Benet L Z; Lin E T
Stereoselective disposition of ketoprofen in rats.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(3):717-8.
1991: Benet L Z
Rho Chi Lecture. Ideals and innovation: drugs, generics, the FDA, and the pharmacist.
DICP : the annals of pharmacotherapy 1991;25(4):427-30.
1991: Lau D T; Gumbleton M; Labisch C; Benet L Z
Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat.
Biopharmaceutics & drug disposition 1991;12(3):215-22.
1991: Gumbleton M; Benet L Z
Drug metabolism and laboratory anesthetic protocols in the rat: examination of antipyrine pharmacokinetics.
Pharmaceutical research 1991;8(4):544-6.
1991: Hale V G; Benet L Z
Prednisolone and prednisone exhibit linear extraction in the perfused rabbit liver.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(1):87-93.
1991: Volland C; Benet L Z
In vitro enantioselective glucuronidation of fenoprofen.
Pharmacology 1991;43(2):53-60.
1990: Lee F W; Salmonson T; Metzler C H; Benet L Z
Pharmacokinetics and pharmacodynamics of glyceryl trinitrate and its two dinitrate metabolites in conscious dogs.
The Journal of pharmacology and experimental therapeutics 1990;255(3):1222-9.
1990: Volland C; Sun H; Benet L Z
Stereoselective analysis of fenoprofen and its metabolites.
Journal of chromatography 1990;534():127-38.
1990: Smith P C; Benet L Z; McDonagh A F
Covalent binding of zomepirac glucuronide to proteins: evidence for a Schiff base mechanism.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(5):639-44.
1990: Manfro R C; Pohanka E; Tomlanovich S J; Benet L Z; Salvatierra O; Garovoy M R
Determination of soluble IL-2 receptors in kidney graft recipients--a 6-month follow-up.
Transplantation proceedings 1990;22(4):1861-2.
1990: Gupta S K; Manfro R C; Tomlanovich S J; Gambertoglio J G; Garovoy M R; Benet L Z
Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration.
Journal of clinical pharmacology 1990;30(7):643-53.
1990: Nakashima E; Rigod J F; Lin E T; Benet L Z
Pharmacokinetics of nitroglycerin and its dinitrate metabolites over a thirtyfold range of oral doses.
Clinical pharmacology and therapeutics 1990;47(5):592-8.
1990: Lau D T; Benet L Z
Nitroglycerin metabolism in subcellular fractions of rabbit liver. Dose dependency of glyceryl dinitrate formation and possible involvement of multiple isozymes of glutathione S-transferases.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(3):292-7.
1990: Williams R L; Lin E T; Liang-Gee W; Blume C D; Benet L Z
Absorption and disposition of a new low-dose combination formulation of hydrochlorothiazide and triamterene.
Biopharmaceutics & drug disposition 1990;11(3):233-43.
1990: Hamamoto K; Iwamoto H S; Roman C M; Benet L Z; Rudolph A M
Fetal uptake of intraamniotic digoxin in sheep.
Pediatric research 1990;27(3):282-5.
1990: Iwakawa S; Spahn H; Benet L Z; Lin E T
Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin.
Biochemical pharmacology 1990;39(5):949-53.
1990: Gupta S K; Benet L Z
High-fat meals increase the clearance of cyclosporine.
Pharmaceutical research 1990;7(1):46-8.
1990: Munafo A; McDonagh A F; Smith P C; Benet L Z
Irreversible binding of tolmetin glucuronic acid esters to albumin in vitro.
Pharmaceutical research 1990;7(1):21-7.
1990: Smith P C; McDonagh A F; Benet L Z
Effect of esterase inhibition on the disposition of zomepirac glucuronide and its covalent binding to plasma proteins in the guinea pig.
The Journal of pharmacology and experimental therapeutics 1990;252(1):218-24.
1990: Wang L H; Rudolph A M; Benet L Z
Comparative study of acetaminophen disposition in sheep at three developmental stages: the fetal, neonatal and adult periods.
Developmental pharmacology and therapeutics 1990;14(3):161-79.
1989: Nakashima E; Benet L Z
An integrated approach to pharmacokinetic analysis for linear mammillary systems in which input and exit may occur in/from any compartment.
Journal of pharmacokinetics and biopharmaceutics 1989;17(6):673-86.
1989: Gupta S K; Benet L Z
Absorption kinetics of cyclosporine in healthy volunteers.
Biopharmaceutics & drug disposition 1989;10(6):591-6.
1989: Watari N; Benet L Z
Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs.
Journal of pharmacokinetics and biopharmaceutics 1989;17(5):593-9.
1989: Teng R L; Benet L Z
Simultaneous measurement of prednisone, prednisolone and 6 beta-hydroxyprednisolone in urine by high-performance liquid chromatography using dexamethasone as the internal standard.
Journal of chromatography 1989;493(2):421-3.
1989: Iwakawa S; Suganuma T; Lee S F; Spahn H; Benet L Z; Lin E T
Direct determination of diastereomeric carprofen glucuronides in human plasma and urine and preliminary measurements of stereoselective metabolic and renal elimination after oral administration of carprofen in man.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(4):414-9.
1989: Spahn H; Spahn I; Benet L Z
Probenecid-induced changes in the clearance of carprofen enantiomers: a preliminary study.
Clinical pharmacology and therapeutics 1989;45(5):500-5.
1989: Gloff C A; Benet L Z
Differential effects of the degree of renal damage on p-aminohippuric acid and inulin clearances in rats.
Journal of pharmacokinetics and biopharmaceutics 1989;17(2):169-77.
1989: Spahn H; Iwakawa S; Lin E T; Benet L Z
Procedures to characterize in vivo and in vitro enantioselective glucuronidation properly: studies with benoxaprofen glucuronides.
Pharmaceutical research 1989;6(2):125-32.
1989: Hammarlund-Udenaes M; Benet L Z
Furosemide pharmacokinetics and pharmacodynamics in health and disease--an update.
Journal of pharmacokinetics and biopharmaceutics 1989;17(1):1-46.
1989: Manfro R C; Pohanka E; Tomlanovich S; Benet L Z; Garovoy M R
Cyclosporin A and prednisolone: an additive inhibitory effect of cell proliferation and interleukin-2 production.
Transplantation proceedings 1989;21(1 Pt 2):1457-9.
1989: Lau D T; Benet L Z
Differential formation of dinitrate metabolites from glyceryl trinitrate in subcellular fractions of rabbit liver.
Biochemical pharmacology 1989;38(3):543-6.
1988: Nakashima E; Benet L Z
General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment.
Journal of pharmacokinetics and biopharmaceutics 1988;16(5):475-92.
1988: Gawienowski M; Benet L Z; Fleckenstein L; Lin E T
Ion-paired liquid chromatographic method for the analysis of blood and plasma for the antimalarial drug halofantrine and its putative mono-debutylated metabolite.
Journal of chromatography 1988;430(2):412-9.
1988: Hyneck M L; Smith P C; Munafo A; McDonagh A F; Benet L Z
Disposition and irreversible plasma protein binding of tolmetin in humans.
Clinical pharmacology and therapeutics 1988;44(1):107-14.
1988: Schwartz J B; Upton R A; Lin E T; Williams R L; Benet L Z
Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics.
Clinical pharmacology and therapeutics 1988;43(6):673-80.
1988: Lee F W; Watari N; Rigod J; Benet L Z
Simultaneous determination of nitroglycerin and its dinitrate metabolites by capillary gas chromatography with electron-capture detection.
Journal of chromatography 1988;426(2):259-66.
1988: Hyneck M L; Munafo A; Benet L Z
Effect of pH on acyl migration and hydrolysis of tolmetin glucuronide.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(2):322-4.
1988: Gloff C A; Mamelok R D; Benet L Z
Organic anion transport by basal-lateral membranes: effect of PAH and furosemide on each other's transport.
Pharmacology 1988;37(4):268-76.
1987: Hyneck M L; Smith P C; Unseld E; Benet L Z
High-performance liquid chromatographic determination of tolmetin, tolmetin glucuronide and its isomeric conjugates in plasma and urine.
Journal of chromatography 1987;420(2):349-56.
1987: Williams R L; Mordenti J; Upton R A; Lin E T; Gee W L; Blume C D; Benet L Z
Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products.
Pharmaceutical research 1987;4(4):348-52.
1987: Nakashima E; Noonan P K; Benet L Z
Transdermal bioavailability and first-pass skin metabolism: a preliminary evaluation with nitroglycerin.
Journal of pharmacokinetics and biopharmaceutics 1987;15(4):423-37.
1986: Williams R L; Thornhill M D; Upton R A; Blume C; Clark T S; Lin E; Benet L Z
Absorption and disposition of two combination formulations of hydrochlorothiazide and triamterene: influence of age and renal function.
Clinical pharmacology and therapeutics 1986;40(2):226-32.
1984: Upton R A; Williams R L; Lin E T; Gee W L; Blume C D; Benet L Z
Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered.
Journal of pharmacokinetics and biopharmaceutics 1984;12(6):575-86.
1984: Blume C D; Williams R L; Upton R A; Lin E T; Benet L Z
Bioequivalence study of a new tablet formulation of triamterene and hydrochlorothiazide.
The American journal of medicine 1984;77(5A):59-61.
1982: Williams R L; Blume C D; Lin E T; Holford N H; Benet L Z
Relative bioavailability of chlorthalidone in humans: adverse influence of polyethylene glycol.
Journal of pharmaceutical sciences 1982;71(5):533-5.

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