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Peter O'Brien

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Living Beings

Chemicals & Drugs

Anatomy

Physiology

Phenomena

Oxidation-Reduction

Disorders

Oxidative Stress

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Co-Publications
Name
28
Khan, Sumsullah
22
Chan, Tom
18
Shangari, Nandita
17
Moridani, Majid
16
Siraki, Arno
16
Galati, Giuseppe
12
Pourahmad, Jalal
8
Bruce, Robert
8
Mehta, Rhea
8
Tafazoli, Shahrzad
7
Chan, Katie
6
Teng, Shirley
6
Wilson, John
5
Scobie, Hugh
5
Poon, Raymond

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Publications

TOP 3
Truong D; Hindmarsh W; O'Brien P J
The molecular mechanisms of diallyl disulfide and diallyl sulfide induced hepatocyte cytotoxicity.
Feng C Y; Wong S; Dong Q; Bruce J; Mehta R; Bruce W R; O'Brien P J
Hepatocyte inflammation model for cytotoxicity research: fructose or glycolaldehyde as a source of endogenous toxins.
Mehta Rhea; Wong Lilian; O'Brien Peter J
Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes.

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All Publications

2009: Truong D; Hindmarsh W; O'Brien P J
The molecular mechanisms of diallyl disulfide and diallyl sulfide induced hepatocyte cytotoxicity.
Chemico-biological interactions 2009;180(1):79-88.
2009: Feng C Y; Wong S; Dong Q; Bruce J; Mehta R; Bruce W R; O'Brien P J
Hepatocyte inflammation model for cytotoxicity research: fructose or glycolaldehyde as a source of endogenous toxins.
Archives of physiology and biochemistry 2009;115(2):105-11.
2009: Mehta Rhea; Wong Lilian; O'Brien Peter J
Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes.
Chemico-biological interactions 2009;178(1-3):317-23.
2009: Lee O; Bruce W R; Dong Q; Bruce J; Mehta R; O'Brien P J
Fructose and carbonyl metabolites as endogenous toxins.
Chemico-biological interactions 2009;178(1-3):332-9.
2009: Banach Monica S; Dong Qiang; O'Brien Peter J
Hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) or glyoxal (carbonylation model): prevention by bioactive nut extracts or catechins.
Chemico-biological interactions 2009;178(1-3):324-31.
2009: Tafazoli Shahrzad; O'Brien Peter J
Amodiaquine-induced oxidative stress in a hepatocyte inflammation model.
Toxicology 2009;256(1-2):101-9.
2008: Chan Katie; Poon Raymond; O'Brien Peter J
Application of structure-activity relationships to investigate the molecular mechanisms of hepatocyte toxicity and electrophilic reactivity of alpha,beta-unsaturated aldehydes.
Journal of applied toxicology : JAT 2008;28(8):1027-39.
2008: Chan Katie; O'Brien Peter J
Structure-activity relationships for hepatocyte toxicity and electrophilic reactivity of alpha,beta-unsaturated esters, acrylates and methacrylates.
Journal of applied toxicology : JAT 2008;28(8):1004-15.
2008: Niknahad Hossein; O'Brien Peter J
Mechanism of sulfite cytotoxicity in isolated rat hepatocytes.
Chemico-biological interactions 2008;174(3):147-54.
2008: Chan Katie; Jensen Neil; O'Brien Peter J
Structure-activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p-benzoquinone compounds.
Journal of applied toxicology : JAT 2008;28(5):608-20.
2008: Tafazoli Shahrzad; Mashregi Mariam; O'Brien Peter J
Role of hydrazine in isoniazid-induced hepatotoxicity in a hepatocyte inflammation model.
Toxicology and applied pharmacology 2008;229(1):94-101.
2008: Tafazoli Shahrzad; O'Brien Peter J
Accelerated cytotoxic mechanism screening of hydralazine using an in vitro hepatocyte inflammatory cell peroxidase model.
Chemical research in toxicology 2008;21(4):904-10.
2008: Pourahmad Jalal; O'Brien Peter J; Chan Katie; Shakouri Ataollah
Tetramethylphenylenediamine-induced hepatocyte cytotoxicity caused by lysosomal labilisation and redox cycling with oxygen activation.
Chemico-biological interactions 2008;172(1):39-47.
2008: Mehta Rhea; Shangari Nandita; O'Brien Peter J
Preventing cell death induced by carbonyl stress, oxidative stress or mitochondrial toxins with vitamin B anti-AGE agents.
Molecular nutrition & food research 2008;52(3):379-85.
2007: Truong Don H; Mihajlovic Aleksandra; Gunness Patrina; Hindmarsh Wayne; O'Brien Peter J
Prevention of hydrogen sulfide (H2S)-induced mouse lethality and cytotoxicity by hydroxocobalamin (vitamin B(12a)).
Toxicology 2007;242(1-3):16-22.
2007: Shangari Nandita; Depeint Flore; Furrer Rudolf; Bruce W Robert; Popovic Marija; Zheng Feng; O'Brien Peter J
A thermolyzed diet increases oxidative stress, plasma alpha-aldehydes and colonic inflammation in the rat.
Chemico-biological interactions 2007;169(2):100-9.
2007: Shangari Nandita; Chan Tom S; Chan Katie; Huai Wu Shuo; O'Brien Peter J
Copper-catalyzed ascorbate oxidation results in glyoxal/AGE formation and cytotoxicity.
Molecular nutrition & food research 2007;51(4):445-55.
2007: Chan Katie; Jensen Neil S; Silber Paul M; O'Brien Peter J
Structure-activity relationships for halobenzene induced cytotoxicity in rat and human hepatocytes.
Chemico-biological interactions 2007;165(3):165-74.
2007: Shangari Nandita; Mehta Rhea; O'brien Peter J
Hepatocyte susceptibility to glyoxal is dependent on cell thiamin content.
Chemico-biological interactions 2007;165(2):146-54.
2007: Shuhendler Adam J; O'Brien Peter J; Rauth Andrew M; Wu Xiao Yu
On the synergistic effect of doxorubicin and mitomycin C against breast cancer cells.
Drug metabolism and drug interactions 2007;22(4):201-33.
2006: Mehta Rhea; Templeton Douglas M; O'brien Peter J
Mitochondrial involvement in genetically determined transition metal toxicity II. Copper toxicity.
Chemico-biological interactions 2006;163(1-2):77-85.
2006: Depeint Flore; Bruce W Robert; Shangari Nandita; Mehta Rhea; O'Brien Peter J
Mitochondrial function and toxicity: role of B vitamins on the one-carbon transfer pathways.
Chemico-biological interactions 2006;163(1-2):113-32.
2006: Huang Xi-Ping; O'Brien Peter J; Templeton Douglas M
Mitochondrial involvement in genetically determined transition metal toxicity I. Iron toxicity.
Chemico-biological interactions 2006;163(1-2):68-76.
2006: Depeint Flore; Bruce W Robert; Shangari Nandita; Mehta Rhea; O'Brien Peter J
Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism.
Chemico-biological interactions 2006;163(1-2):94-112.
2006: Shangari Nandita; Chan Tom S; Popovic Marija; O'Brien Peter J
Glyoxal markedly compromises hepatocyte resistance to hydrogen peroxide.
Biochemical pharmacology 2006;71(11):1610-8.
2006: Li Lin Alison; Shangari Nandita; Chan Tom S; Remirez Diadelas; O'Brien Peter J
Herbal monoterpene alcohols inhibit propofol metabolism and prolong anesthesia time.
Life sciences 2006;79(1):21-9.
2006: Dragan Magdalena; Dixon S Jeffrey; Jaworski Ewa; Chan Tom S; O'brien Peter J; Wilson John X
Coenzyme Q(1) depletes NAD(P)H and impairs recycling of ascorbate in astrocytes.
Brain research 2006;1078(1):9-18.
2006: Galati Giuseppe; Lin Alison; Sultan Amira M; O'Brien Peter J
Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins.
Free radical biology & medicine 2006;40(4):570-80.
2006: Truong Don H; Eghbal Mohammad A; Hindmarsh Wayne; Roth Sheldon H; O'Brien Peter J
Molecular mechanisms of hydrogen sulfide toxicity.
Drug metabolism reviews 2006;38(4):733-44.
2005: Chan Katie; Truong Don; Shangari Nandita; O'Brien Peter J
Drug-induced mitochondrial toxicity.
Expert opinion on drug metabolism & toxicology 2005;1(4):655-69.
2005: Tafazoli Shahrzad; Wright James S; O'Brien Peter J
Prooxidant and antioxidant activity of vitamin E analogues and troglitazone.
Chemical research in toxicology 2005;18(10):1567-74.
2005: Shangari Nandita; Depeint Flore; Furrer Rudolf; Bruce W Robert; O'Brien Peter J
The effects of partial thiamin deficiency and oxidative stress (i.e., glyoxal and methylglyoxal) on the levels of alpha-oxoaldehyde plasma protein adducts in Fischer 344 rats.
FEBS letters 2005;579(25):5596-602.
2005: O'Brien Peter J; Siraki Arno G; Shangari Nandita
Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health.
Critical reviews in toxicology 2005;35(7):609-62.
2005: Martin Jonathan W; Mabury Scott A; O'Brien Peter J
Metabolic products and pathways of fluorotelomer alcohols in isolated rat hepatocytes.
Chemico-biological interactions 2005;155(3):165-80.
2005: Tafazoli Shahrzad; O'Brien Peter J
Peroxidases: a role in the metabolism and side effects of drugs.
Drug discovery today 2005;10(9):617-25.
2005: O'Brien P J; Siraki A G
Accelerated cytotoxicity mechanism screening using drug metabolising enzyme modulators.
Current drug metabolism 2005;6(2):101-9.
2005: Chan Tom S; Shangari Nandita; Wilson John X; Chan Helen; Butterworth Roger F; O'Brien Peter J
The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress.
Free radical biology & medicine 2005;38(7):867-73.
2005: Siraki Arno G; Chevaldina Tatiana; O'Brien Peter J
Application of quantitative structure-toxicity relationships for acute NSAID cytotoxicity in rat hepatocytes.
Chemico-biological interactions 2005;151(3):177-91.
2005: Pourahmad Jalal; Rabiei Maryam; Jokar Farzaneh; O'brien Peter J
A comparison of hepatocyte cytotoxic mechanisms for chromate and arsenite.
Toxicology 2005;206(3):449-60.
2005: Shangari Nandita; Chan Tom S; O'Brien Peter J
Sulfation and glucuronidation of phenols: implications in coenyzme Q metabolism.
Methods in enzymology 2005;400():342-59.
2005: Kovacic Peter; Pozos Robert S; Somanathan Ratnasamy; Shangari Nandita; O'Brien Peter J
Mechanism of mitochondrial uncouplers, inhibitors, and toxins: focus on electron transfer, free radicals, and structure-activity relationships.
Current medicinal chemistry 2005;12(22):2601-23.
2005: Tafazoli Shahrzad; Spehar Dane D; O'Brien Peter J
Oxidative stress mediated idiosyncratic drug toxicity.
Drug metabolism reviews 2005;37(2):311-25.
2004: Eghbal Mohammad A; Tafazoli Shahrzad; Pennefather Peter; O'Brien Peter J
Peroxidase catalysed formation of cytotoxic prooxidant phenothiazine free radicals at physiological pH.
Chemico-biological interactions 2004;151(1):43-51.
2004: O'Brien Peter J; Chan Katie; Silber Paul M
Human and animal hepatocytes in vitro with extrapolation in vivo.
Chemico-biological interactions 2004;150(1):97-114.
2004: Tafazoli Shahrzad; O'brien Peter J
Prooxidant activity and cytotoxic effects of indole-3-acetic acid derivative radicals.
Chemical research in toxicology 2004;17(10):1350-5.
2004: Eghbal Mohammad A; Pennefather Peter S; O'Brien Peter J
H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation.
Toxicology 2004;203(1-3):69-76.
2004: Shangari Nandita; O'Brien Peter J
The cytotoxic mechanism of glyoxal involves oxidative stress.
Biochemical pharmacology 2004;68(7):1433-42.
2004: Siraki Arno G; Chan Tom S; O'Brien Peter J
Application of quantitative structure-toxicity relationships for the comparison of the cytotoxicity of 14 p-benzoquinone congeners in primary cultured rat hepatocytes versus PC12 cells.
Toxicological sciences : an official journal of the Society of Toxicology 2004;81(1):148-59.
2004: Galati Giuseppe; O'Brien Peter J
Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties.
Free radical biology & medicine 2004;37(3):287-303.
2004: Sabzevari Omid; Galati Giuseppe; Moridani Majid Y; Siraki Arno; O'Brien Peter J
Molecular cytotoxic mechanisms of anticancer hydroxychalcones.
Chemico-biological interactions 2004;148(1-2):57-67.
2004: Moridani Majid Y; Siraki Arno; Chevaldina Tatiana; Scobie Hugh; O'Brien Peter J
Quantitative structure toxicity relationships for catechols in isolated rat hepatocytes.
Chemico-biological interactions 2004;147(3):297-307.
2004: Chan Tom S; Wilson John X; O'Brien Peter J
Glycogenolysis is directed towards ascorbate synthesis by glutathione conjugation.
Biochemical and biophysical research communications 2004;317(1):149-56.
2004: Siraki Arno G; Chevaldina Tatiana; Moridani Majid Y; O'Brien Peter J
Quantitative structure-toxicity relationships by accelerated cytotoxicity mechanism screening.
Current opinion in drug discovery & development 2004;7(1):118-25.
2004: Chan Tom S; Wilson John X; O'Brien Peter J
Coenzyme Q cytoprotective mechanisms.
Methods in enzymology 2004;382():89-104.
2003: Bruce W Robert; Furrer Rudolf; Shangari Nandita; O'Brien Peter J; Medline Alan; Wang Yanping
Marginal dietary thiamin deficiency induces the formation of colonic aberrant crypt foci (ACF) in rats.
Cancer letters 2003;202(2):125-9.
2003: Shangari N; Bruce W R; Poon R; O'Brien P J
Toxicity of glyoxals--role of oxidative stress, metabolic detoxification and thiamine deficiency.
Biochemical Society transactions 2003;31(Pt 6):1390-3.
2003: Pourahmad Jalal; O'Brien Peter J; Jokar Farzaneh; Daraei Bahram
Carcinogenic metal induced sites of reactive oxygen species formation in hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(5-6):803-10.
2003: Beard Kristin M; Shangari Nandita; Wu Bin; O'Brien Peter J
Metabolism, not autoxidation, plays a role in alpha-oxoaldehyde- and reducing sugar-induced erythrocyte GSH depletion: relevance for diabetes mellitus.
Molecular and cellular biochemistry 2003;252(1-2):331-8.
2003: Abdollahi Mohammad; Chan Tom S; Subrahmanyam Vangala; O'Brien Peter J
Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin.
Molecular and cellular biochemistry 2003;252(1-2):205-11.
2003: Chan Tom S; Galati Giuseppe; Pannala Ananth S; Rice-Evans Catherine; O'Brien Peter J
Simultaneous detection of the antioxidant and pro-oxidant activity of dietary polyphenolics in a peroxidase system.
Free radical research 2003;37(7):787-94.
2003: Moridani Majid Y; Siraki Arno; O'Brien Peter J
Quantitative structure toxicity relationships for phenols in isolated rat hepatocytes.
Chemico-biological interactions 2003;145(2):213-23.
2003: Niknahad Hossein; Shuhendler Adam; Galati Giuseppe; Siraki Arno G; Easson Elaine; Poon Raymond; O'Brien Peter J
Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl metabolizing enzymes. II. Aromatic aldehydes.
Chemico-biological interactions 2003;143-144():119-28.
2003: Niknahad Hossein; Siraki Arno G; Shuhendler Adam; Khan Sumsullah; Teng Shirley; Galati Giuseppe; Easson Elaine; Poon Raymond; O'Brien Peter J
Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. I. Aliphatic alkenals.
Chemico-biological interactions 2003;143-144():107-17.
2003: Moridani Majid Y; Pourahmad Jalal; Bui Hoang; Siraki Arno; O'Brien Peter J
Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers.
Free radical biology & medicine 2003;34(2):243-53.
2003: Moridani Majid Y; Cheon Sophia S; Khan Sumsullah; O'Brien Peter J
Metabolic activation of 3-hydroxyanisole by isolated rat hepatocytes.
Chemico-biological interactions 2003;142(3):317-33.
2003: Chan Tom S; O'Brien Peter J
Hepatocyte metabolism of coenzyme Q1 (ubiquinone-5) to its sulfate conjugate decreases its antioxidant activity.
BioFactors (Oxford, England) 2003;18(1-4):207-18.
2003: Galati Giuseppe; O'Brien Peter J
Cytoprotective and anticancer properties of coenzyme Q versus capsaicin.
BioFactors (Oxford, England) 2003;18(1-4):195-205.
2002: Galati Giuseppe; Tafazoli Shahrzad; Sabzevari Omid; Chan Tom S; O'Brien Peter J
Idiosyncratic NSAID drug induced oxidative stress.
Chemico-biological interactions 2002;142(1-2):25-41.
2002: Moridani M Y; Cheon S S; Khan S; O'Brien P J
Metabolic activation of 4-hydroxyanisole by isolated rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(10):1063-9.
2002: Siraki Arno G; Chan Tom S; Galati Giuseppe; Teng Shirley; O'Brien Peter J
N-oxidation of aromatic amines by intracellular oxidases.
Drug metabolism reviews 2002;34(3):549-64.
2002: Galati Giuseppe; Sabzevari Omid; Wilson John X; O'Brien Peter J
Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics.
Toxicology 2002;177(1):91-104.
2002: Siraki Arno G; O'Brien Peter J
Prooxidant activity of free radicals derived from phenol-containing neurotransmitters.
Toxicology 2002;177(1):81-90.
2002: Moridani Majid Y; Scobie Hugh; O'Brien Peter J
Metabolism of caffeic acid by isolated rat hepatocytes and subcellular fractions.
Toxicology letters 2002;133(2-3):141-51.
2002: Chan Tom S; Teng Shirley; Wilson John X; Galati Giuseppe; Khan Sumsallah; O'Brien Peter J
Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: quinone oxidoreductase 1(NQO1).
Free radical research 2002;36(4):421-7.
2002: Moridani Majid Y; Galati Giuseppe; O'Brien Peter J
Comparative quantitative structure toxicity relationships for flavonoids evaluated in isolated rat hepatocytes and HeLa tumor cells.
Chemico-biological interactions 2002;139(3):251-64.
2002: Siraki Arno G; Pourahmad Jalal; Chan Tom S; Khan Sumsullah; O'Brien Peter J
Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes.
Free radical biology & medicine 2002;32(1):2-10.
2001: Moridani M Y; O'Brien P J
Iron complexes of deferiprone and dietary plant catechols as cytoprotective superoxide radical scavengers(1).
Biochemical pharmacology 2001;62(12):1579-85.
2001: Moridani M Y; Scobie H; Jamshidzadeh A; Salehi P; O'Brien P J
Caffeic acid, chlorogenic acid, and dihydrocaffeic acid metabolism: glutathione conjugate formation.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1432-9.
2001: Moridani M Y; Scobie H; Salehi P; O'Brien P J
Catechin metabolism: glutathione conjugate formation catalyzed by tyrosinase, peroxidase, and cytochrome p450.
Chemical research in toxicology 2001;14(7):841-8.
2001: Galati G; Moridani M Y; Chan T S; O'Brien P J
Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation.
Free radical biology & medicine 2001;30(4):370-82.
2001: Moridani M Y; Khan S; Chan T; Teng S; Beard K; O'Brien P J
Cytochrome P450 2E1 metabolically activates propargyl alcohol: propiolaldehyde-induced hepatocyte cytotoxicity.
Chemico-biological interactions 2001;130-132(1-3):931-42.
2001: Teng S; Beard K; Pourahmad J; Moridani M; Easson E; Poon R; O'Brien P J
The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes.
Chemico-biological interactions 2001;130-132(1-3):285-96.
2001: Pourahmad J; Ross S; O'Brien P J
Lysosomal involvement in hepatocyte cytotoxicity induced by Cu(2+) but not Cd(2+).
Free radical biology & medicine 2001;30(1):89-97.
2001: Pourahmad J; Khan S; O'Brien P J
Lysosomal oxidative stress cytotoxicity induced by nitrofurantoin redox cycling in hepatocytes.
Advances in experimental medicine and biology 2001;500():261-5.
2001: Pourahmad J; Mihajlovic A; O'Brien P J
Hepatocyte lysis induced by environmental metal toxins may involve apoptotic death signals initiated by mitochondrial injury.
Advances in experimental medicine and biology 2001;500():249-52.
2001: Chan T S; Moridani M; Siraki A; Scobie H; Beard K; Eghbal M A; Galati G; O'Brien P J
Hydrogen peroxide supports hepatocyte P450 catalysed xenobiotic/drug metabolic activation to form cytotoxic reactive intermediates.
Advances in experimental medicine and biology 2001;500():233-6.
2001: Pourahmad J; O'Brien P J
Biological reactive intermediates that mediate chromium (VI) toxicity.
Advances in experimental medicine and biology 2001;500():203-7.
2000: O'Brien P J
Peroxidases.
Chemico-biological interactions 2000;129(1-2):113-39.
2000: Siraki A G; Smythies J; O'Brien P J
Superoxide radical scavenging and attenuation of hypoxia-reoxygenation injury by neurotransmitter ferric complexes in isolated rat hepatocytes.
Neuroscience letters 2000;296(1):37-40.
2000: Pourahmad J; O'Brien P J
Contrasting role of Na(+) ions in modulating Cu(+2) or Cd(+2) induced hepatocyte toxicity.
Chemico-biological interactions 2000;126(2):159-69.
2000: Pourahmad J; O'Brien P J
A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+.
Toxicology 2000;143(3):263-73.
2000: Galati G; Teng S; Moridani M Y; Chan T S; O'Brien P J
Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics.
Drug metabolism and drug interactions 2000;17(1-4):311-49.
1999: Khan S; O'Brien P J
Role of the cellular redox state in modulating acute ethanol toxicity in isolated hepatocytes.
Clinical biochemistry 1999;32(7):585-9.
1999: Chan T; Galati G; O'Brien P J
Oxygen activation during peroxidase catalysed metabolism of flavones or flavanones.
Chemico-biological interactions 1999;122(1):15-25.
1999: Grinberg L N; O'Brien P J; Hrkal Z
The effects of heme-binding proteins on the peroxidative and catalatic activities of hemin.
Free radical biology & medicine 1999;27(1-2):214-9.
1999: Galati G; Chan T; Wu B; O'Brien P J
Glutathione-dependent generation of reactive oxygen species by the peroxidase-catalyzed redox cycling of flavonoids.
Chemical research in toxicology 1999;12(6):521-5.
1998: Zhao Z S; Khan S; O'Brien P J
Catecholic iron complexes as cytoprotective superoxide scavengers against hypoxia:reoxygenation injury in isolated hepatocytes.
Biochemical pharmacology 1998;56(7):825-30.
1998: Huang J; Niknahad H; Khan S; O'Brien P J
Hepatocyte-catalysed detoxification of cyanide by L- and D-cysteine.
Biochemical pharmacology 1998;55(12):1983-90.
1998: Huang J; Khan S; O'Brien P J
The glutathione dependence of inorganic sulfate formation from L- or D-cysteine in isolated rat hepatocytes.
Chemico-biological interactions 1998;110(3):189-202.
1997: Zhao Z S; Khan S; O'Brien P J
The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants.
Chemico-biological interactions 1997;108(1-2):107-18.
1997: Anari M R; Khan S; Jatoe S D; O'Brien P J
Cytochrome P450 dependent xenobiotic activation by physiological hydroperoxides in intact hepatocytes.
European journal of drug metabolism and pharmacokinetics 1997;22(4):305-10.
1997: Khan S; O'Brien P J
Rapid and specific efflux of glutathione before hepatocyte injury induced by hypoxia.
Biochemical and biophysical research communications 1997;238(2):320-2.
1997: Sood C; Khan S; O'Brien P J
Phenylenediamine induced hepatocyte cytotoxicity redox. Cycling mediated oxidative stress without oxygen activation.
Biochimica et biophysica acta 1997;1335(3):343-52.
1997: Anari M R; Josephy P D; Henry T; O'Brien P J
Hydrogen peroxide supports human and rat cytochrome P450 1A2-catalyzed 2-amino-3-methylimidazo[4,5-f]quinoline bioactivation to mutagenic metabolites: significance of cytochrome P450 peroxygenase.
Chemical research in toxicology 1997;10(5):582-8.
1996: Zhao Z S; O'Brien P J
The prevention of CCl4-induced liver necrosis in mice by naturally occurring methylenedioxybenzenes.
Toxicology and applied pharmacology 1996;140(2):411-21.
1996: Anari M R; Khan S; O'Brien P J
The involvement of cytochrome P450 peroxidase in the metabolic bioactivation of cumene hydroperoxide by isolated rat hepatocytes.
Chemical research in toxicology 1996;9(6):924-31.
1996: Sood C; O'Brien P J
2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity.
The British journal of cancer. Supplement 1996;27():S287-93.
1996: Halinska A; Belej T; O'Brien P J
Cytotoxic mechanisms of anti-tumour quinones in parental and resistant lymphoblasts.
The British journal of cancer. Supplement 1996;27():S23-7.
1996: Niknahad H; O'Brien P J
Antidotal effect of dihydroxyacetone against cyanide toxicity in vivo.
Toxicology and applied pharmacology 1996;138(1):186-91.
1996: Niknahad H; O'Brien P J
Involvement of nitric oxide in nitroprusside-induced hepatocyte cytotoxicity.
Biochemical pharmacology 1996;51(8):1031-9.
1996: Khan S; Sood C; O'Brien P J
The involvement of cytochrome P4502E1 in 2-bromoethanol-induced hepatocyte cytotoxicity.
Pharmacology & toxicology 1996;78(4):241-8.
1995: Anari M R; Khan S; Liu Z C; O'Brien P J
Cytochrome P450 peroxidase/peroxygenase mediated xenobiotic metabolic activation and cytotoxicity in isolated hepatocytes.
Chemical research in toxicology 1995;8(8):997-1004.
1995: Niknahad H; Khan S; O'Brien P J
Oxygen dependence of hepatocyte susceptibility to mitochondrial respiratory inhibitors.
Biochemical pharmacology 1995;50(11):1859-65.
1995: Khan S; O'Brien P J
Modulating hypoxia-induced hepatocyte injury by affecting intracellular redox state.
Biochimica et biophysica acta 1995;1269(2):153-61.
1995: Niknahad H; Khan S; O'Brien P J
Hepatocyte injury resulting from the inhibition of mitochondrial respiration at low oxygen concentrations involves reductive stress and oxygen activation.
Chemico-biological interactions 1995;98(1):27-44.
1995: Khan S; O'Brien P J
Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations.
British journal of cancer 1995;71(4):780-5.
1995: Niknahad H; O'Brien P J
Cytotoxicity induced by N-methyl-N'-nitro-N-nitrosoguanidine may involve S-nitrosyl glutathione and nitric oxide.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(1):91-101.
1994: Niknahad H; Khan S; Sood C; O'Brien P J
Prevention of cyanide-induced cytotoxicity by nutrients in isolated rat hepatocytes.
Toxicology and applied pharmacology 1994;128(2):271-9.
1994: Sood C; O'Brien P J
Chloroacetaldehyde-induced hepatocyte cytotoxicity. Mechanisms for cytoprotection.
Biochemical pharmacology 1994;48(5):1025-32.
1994: O'Brien P J
Antioxidants and cancer: molecular mechanisms.
Advances in experimental medicine and biology 1994;366():215-39.
1993: Sood C; O'Brien P J
Molecular mechanisms of chloroacetaldehyde-induced cytotoxicity in isolated rat hepatocytes.
Biochemical pharmacology 1993;46(9):1621-6.
1993: Silva J M; O'Brien P J
Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions.
British journal of cancer 1993;68(3):484-91.
1993: Silva J M; Khan S; O'Brien P J
Molecular mechanisms of nitrofurantoin-induced hepatocyte toxicity in aerobic versus hypoxic conditions.
Archives of biochemistry and biophysics 1993;305(2):362-9.
1993: Meloche B A; O'Brien P J
S-nitrosyl glutathione-mediated hepatocyte cytotoxicity.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(8):863-71.
1993: Silva J M; Khan S; O'Brien P J
Contrasting molecular cytotoxic mechanisms of mitomycin C and its two analogs, BMY 25282 and BMY 25067, in isolated rat hepatocytes.
Biochemical pharmacology 1993;45(11):2303-9.
1993: Khan S; Sood C; O'Brien P J
Molecular mechanisms of dibromoalkane cytotoxicity in isolated rat hepatocytes.
Biochemical pharmacology 1993;45(2):439-47.
1992: Quan Z; Khan S; O'Brien P J
Role of cytochrome P-450IIE1 in N-nitroso-N-methylaniline induced hepatocyte cytotoxicity.
Chemico-biological interactions 1992;83(3):221-33.
1992: Silva J M; Rao D N; O'Brien P J
Modulation of trenimon-induced cytotoxicity by DT-diaphorase in isolated rat hepatocytes under aerobic versus hypoxic conditions.
Cancer research 1992;52(11):3015-21.
1992: Khan S; Ramwani J J; O'Brien P J
Hepatocyte toxicity of mechlorethamine and other alkylating anticancer drugs. Role of lipid peroxidation.
Biochemical pharmacology 1992;43(9):1963-7.
1992: Lauriault V V; Khan S; O'Brien P J
Hepatocyte cytotoxicity induced by various hepatotoxins mediated by cytochrome P-450IIE1: protection with diethyldithiocarbamate administration.
Chemico-biological interactions 1992;81(3):271-89.
1992: Silva J M; O'Brien P J
Molecular mechanisms of trenimon-induced cytotoxicity in resistant L5178Y/HBM10 cells.
International journal of radiation oncology, biology, physics 1992;22(4):639-42.
1991: Silva J M; McGirr L; O'Brien P J
Prevention of nitrofurantoin-induced cytotoxicity in isolated hepatocytes by fructose.
Archives of biochemistry and biophysics 1991;289(2):313-8.
1991: Khan S; O'Brien P J
1-bromoalkanes as new potent nontoxic glutathione depletors in isolated rat hepatocytes.
Biochemical and biophysical research communications 1991;179(1):436-41.
1991: Lauriault V V; O'Brien P J
Molecular mechanism for prevention of N-acetyl-p-benzoquinoneimine cytotoxicity by the permeable thiol drugs diethyldithiocarbamate and dithiothreitol.
Molecular pharmacology 1991;40(1):125-34.
1991: Rao D N; Elguindi S; O'Brien P J
Reductive metabolism of nitroprusside in rat hepatocytes and human erythrocytes.
Archives of biochemistry and biophysics 1991;286(1):30-7.
1991: Lauriault V V; O'Brien P J
Disulfiram may mediate erythrocyte hemolysis induced by diethyldithiocarbamate and 1,4-naphthoquinone-2-sulfonate.
Archives of biochemistry and biophysics 1991;284(1):207-14.
1991: O'Brien P J; Khan S; Jatoe S D
Formation of biological reactive intermediates by peroxidases: halide mediated acetaminophen oxidation and cytotoxicity.
Advances in experimental medicine and biology 1991;283():51-64.
1991: Silva J M; O'Brien P J
Primaquine-induced oxidative stress in isolated hepatocytes as a result of reductive activation.
Advances in experimental medicine and biology 1991;283():359-63.
1991: McGirr L G; O'Brien P J
Glutathione conjugates of hydralazine formed in the peroxidase/hydrogen peroxide/glutathione system.
Advances in experimental medicine and biology 1991;283():337-42.
1991: Elguindi S; O'Brien P J
Cyanide liberation and oxidative stress by organothiocyanates, organonitriles and nitroprusside in isolated hepatocytes.
Advances in experimental medicine and biology 1991;283():271-4.
1991: O'Brien P J
Molecular mechanisms of quinone cytotoxicity.
Chemico-biological interactions 1991;80(1):1-41.
1991: Lauriault V V; O'Brien P J
The antidotal activity of the thiol drug diethyldithiocarbamate against N-acetyl-p-benzoquinone imine in isolated hepatocytes.
Advances in experimental medicine and biology 1991;283():311-4.
1990: Subrahmanyam V V; McGirr L G; O'Brien P J
Peroxidase/hydrogen peroxide--or bone marrow homogenate/hydrogen peroxide--mediated activation of phenol and binding to protein.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(12):1369-78.
1990: Lauriault V V; McGirr L G; Wong W W; O'Brien P J
Modulation of benzoquinone-induced cytotoxicity by diethyldithiocarbamate in isolated hepatocytes.
Archives of biochemistry and biophysics 1990;282(1):26-33.
1990: O'Brien P J; Wong W C; Silva J; Khan S
Toxicity of nitrobenzene compounds towards isolated hepatocytes: dependence on reduction potential.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(9):945-55.
1990: McGirr L G; Khan S; Lauriault V; O'Brien P J
Molecular mechanisms for bromotrichloromethane cytotoxicity in isolated rat hepatocytes.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(9):933-43.
1990: O'Brien P J; Kaul H K; Rauth A M
Differential cytotoxicity of diaziquone toward Chinese hamster ovary cells under hypoxic and aerobic exposure conditions.
Cancer research 1990;50(5):1516-20.
1990: McGirr L G; Jatoe S D; O'Brien P J
Myeloperoxidase catalysed cooxidative metabolism of methimazole: oxidation of glutathione and NADH by free radical intermediates.
Chemico-biological interactions 1990;73(2-3):279-95.
1989: Silva J M; O'Brien P J
Allyl alcohol- and acrolein-induced toxicity in isolated rat hepatocytes.
Archives of biochemistry and biophysics 1989;275(2):551-8.
1989: Silva J M; O'Brien P J
Diaziquone-induced cytotoxicity in isolated rat hepatocytes.
Cancer research 1989;49(20):5550-4.
1989: Lauriault V V; Silva J M; O'Brien P J
Diethyldithiocarbamate (DEDC) enhances quinone mediated oxidative stress cytotoxicity in isolated hepatocytes by forming toxic quinone conjugates.
Drug metabolism and drug interactions 1989;7(1):1-15.
1988: Rossi L; McGirr L G; Silva J; O'Brien P J
The metabolism of N-acetyl-3,5-dimethyl-p-benzoquinone imine in isolated hepatocytes involves N-deacetylation.
Molecular pharmacology 1988;34(5):674-81.
1988: Rossi L; Silva J M; McGirr L G; O'Brien P J
Nitrofurantoin-mediated oxidative stress cytotoxicity in isolated rat hepatocytes.
Biochemical pharmacology 1988;37(16):3109-17.
1988: Jatoe S D; Lauriault V; McGirr L G; O'Brien P J
The toxicity of disulphides to isolated hepatocytes and mitochondria.
Drug metabolism and drug interactions 1988;6(3-4):395-412.
1987: Subrahmanyam V V; McGirr L G; O'Brien P J
Glutathione oxidation during peroxidase catalysed drug metabolism.
Chemico-biological interactions 1987;61(1):45-59.
1986: McGirr L G; Subrahmanyam V V; Moore G A; O'Brien P J
Peroxidase-catalyzed-3-(glutathion-S-yl)-p,p'-biphenol formation.
Chemico-biological interactions 1986;60(1):85-99.

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