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Richard O'Brien

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Antonio Terracciano; Juan C Troncoso; Alan B Zonderman; Angelina R Sutin; Yang An; Luigi Ferrucci; Diego Iacono; Richard J O'Brien; Susan M Resnick
Personality and resilience to Alzheimer's disease neuropathology: a prospective autopsy study.
Steven R Zeiler; Ellen M Gibson; Robert E Hoesch; Ming Y Li; Richard J O'Brien; Paul F Worley; John W Krakauer
Medial premotor cortex shows a reduction in inhibitory markers and mediates recovery in a mouse model of focal stroke.
Carrington R Wendell; Luigi Ferrucci; Richard J O'Brien; James B Strait; Shari R Waldstein; Alan B Zonderman
Carotid atherosclerosis and prospective risk of dementia.

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All Publications

2013: Antonio Terracciano; Juan C Troncoso; Alan B Zonderman; Angelina R Sutin; Yang An; Luigi Ferrucci; Diego Iacono; Richard J O'Brien; Susan M Resnick
Personality and resilience to Alzheimer's disease neuropathology: a prospective autopsy study.
Neurobiology of aging 2013;34(4):1045-50.
2013: Steven R Zeiler; Ellen M Gibson; Robert E Hoesch; Ming Y Li; Richard J O'Brien; Paul F Worley; John W Krakauer
Medial premotor cortex shows a reduction in inhibitory markers and mediates recovery in a mouse model of focal stroke.
Stroke; a journal of cerebral circulation 2013;44(2):483-9.
2012: Carrington R Wendell; Luigi Ferrucci; Richard J O'Brien; James B Strait; Shari R Waldstein; Alan B Zonderman
Carotid atherosclerosis and prospective risk of dementia.
Stroke; a journal of cerebral circulation 2012;43(12):3319-24.
2012: Ira Driscoll; Luigi Ferrucci; William E Klunk; Michael A Kraut; Chester A Mathis; Richard J O'Brien; Olga Pletnikova; Gay Rudow; Jitka Sojkova; Juan C Troncoso; Dean F Wong; Yun Zhou; Christos Davatzikos; Susan M Resnick
Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques.
Acta neuropathologica 2012;124(6):823-31.
2012: Abhay Moghekar; Wendy Elkins; Michael A Kraut; Susan M Resnick; Juan C Troncoso; Alan B Zonderman; Richard J O'Brien
Cerebral white matter disease is associated with Alzheimer pathology in a prospective cohort.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2012;8(5 Suppl):S71-7.
2012: Dena G Hernandez; Matthew Moore; Mike A Nalls; Richard J O'Brien; Mina Ryten; Andrew B Singleton; Colin Smith; Daniah Trabzuni; Bryan Joseph Traynor; Juan C Troncoso; Robert Walker; Michael E Weale; Alan B Zonderman; Sampath Arepalli; Stefania Bandinelli; Sean Chong; Allissa Dillman; J Raphael Gibbs; John Hardy; Mark R Cookson
Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.
Neurobiology of disease 2012;47(1):20-8.
2012: Kari-Elise T Codispoti; Barbara J Crain; Michael A Kraut; Richard J O'Brien; Olga Pletnikova; Gay Rudow; Juan C Troncoso; Lori L Beason-Held; Susan M Resnick
Longitudinal brain activity changes in asymptomatic Alzheimer disease.
Brain and behavior 2012;2(3):221-30.
2012: May A Beydoun; Adel Boueiz; Melissa H Kitner-Triolo; Richard J O'Brien; Susan M Resnick; MARWAN ABOUGERGI; Hind Beydoun; Alan B Zonderman
Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline.
Neurobiology of aging 2012;33(4):720-731.e4.
2012: Abhay Moghekar; Marilyn S Albert; Joshua Goh; Ming Li; Richard J O'Brien
Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort.
Archives of neurology 2012;69(2):246-50.
2011: Niklas Mattsson; John McAuliffe; Marc Mercken; Abhay Moghekar; José Luis Molinuevo; Thomas J Montine; William Nowatzke; Richard J O'Brien; Markus Otto; George P Paraskevas; Lucilla Parnetti; Staffan Persson; Ronald C. Petersen; David Prvulovic; Robert A Rissman; Elio Scarpini; Johannes Schröder; Leslie M Shaw; Anders Skinningsrud; Brith Skrogstad; Hilkka Soininen; Annette Spreer; Alessandro Stefani; Leda Talib; Charlotte Teunissen; John Q Trojanowski; Hayrettin Tumani; Robert M Umek; Bianca Van Broeck; hugo Marcel vanderstichele; Laszlo Vecsei; Marcel M Verbeek; Manfred Windisch; Henrik Zetterberg; Jing Zhang; Luisella Bocchio-Chiavetto; Maria C Carrillo; Sonia Chalbot; Davide Chiasserini; Els Coart; Neal Cutler; Gunilla Dahlfors; Herman P M de Reus; Stefan Duller; Anne M Fagan; Orestes Forlenza; Giovanni B Frisoni; Douglas Galasko; Daniela Galimberti; Harald Hampel; Aase Handberg; Michael T Heneka; Adrianna Z Herskovits; Sanna-Kaisa Herukka; David M Holtzman; Christian Humpel; Bradley T Hyman; Khalid Iqbal; Mathias Jucker; Stephan A Kaeser; Elmar Kaiser; Elisabeth Kapaki; Daniel Kidd; Peter Klivenyi; Cindy S Knudsen; Markus P Kummer; Piotr Lewczuk; Qiao-Xin Li; Albert Lladó; James Lui; Ralph Martins; Colin L Masters; Ulf Andreasson; Hiroyuki Arai; Sat Dev Batish; Sergio Bernardini; Marinus A Blankenstein; Kaj Blennow
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(4):386-395.e6.
2011: Richard J O'Brien
Vascular dementia: atherosclerosis, cognition and Alzheimer's disease.
Current Alzheimer research 2011;8(4):341-4.
2011: Abhay Moghekar; Sneha Rao; MingChang Li; DAWN RUBEN; ANDREW MAMMEN; Xiaopei Tang; Richard J O'Brien
Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro.
The Journal of biological chemistry 2011;286(18):15989-97.
2011: Jitka Sojkova; Ira Driscoll; Diego Iacono; Yun Zhou; Kari-Elise Codispoti; Michael A Kraut; Luigi Ferrucci; Olga Pletnikova; Chester A Mathis; William E Klunk; Richard J O'Brien; Dean F Wong; Juan C Troncoso; Susan M Resnick
In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adults.
Archives of neurology 2011;68(2):232-40.
2011: Frank R Lin; E Jeffrey Metter; Richard J O'Brien; Susan M Resnick; Alan B Zonderman; Luigi Ferrucci
Hearing loss and incident dementia.
Archives of neurology 2011;68(2):214-20.
2011: Richard J O'Brien; Philip C Wong
Amyloid precursor protein processing and Alzheimer's disease.
Annual review of neuroscience 2011;34():185-204.
2011: Ozioma C Okonkwo; Michelle M Mielke; H Randall Griffith; Abhay Moghekar; Richard J O'Brien; Leslie M Shaw; John Q Trojanowski; Marilyn S Albert
Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment.
Archives of neurology 2011;68(1):113-9.
2010: Hillary Dolan; Barbara J Crain; Juan C Troncoso; Susan M Resnick; Alan B Zonderman; Richard J O'Brien
Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort.
Annals of neurology 2010;68(2):231-40.
2010: David Dolan; Juan C Troncoso; Susan M Resnick; Barbara J Crain; Alan B Zonderman; Richard J O'Brien
Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing.
Brain : a journal of neurology 2010;133(Pt 8):2225-31.
2009: Richard J O'Brien; Susan M Resnick; Alan B Zonderman; Luigi Ferrucci; Barbara J Crain; Olga Pletnikova; Gay Rudow; Diego Iacono; Miguel A Riudavets; Ira Driscoll; Donald L Price; Lee J Martin; Juan C Troncoso
Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA).
Journal of Alzheimer's disease : JAD 2009;18(3):665-75.
2008: May A Beydoun; April Lhotsky; Youfa Wang; Gloria Dal Forno; Yang An; E Jeffrey Metter; Luigi Ferrucci; Richard J O'Brien; Alan B Zonderman
Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease.
American journal of epidemiology 2008;168(10):1179-89.
2008: Juan C Troncoso; Alan B Zonderman; Susan M Resnick; Barbara J Crain; Olga Pletnikova; Richard J O'Brien
Effect of infarcts on dementia in the Baltimore longitudinal study of aging.
Annals of neurology 2008;64(2):168-76.
2008: Diego Iacono; Richard J O'Brien; Susan M Resnick; Alan B Zonderman; Olga Pletnikova; Gay Rudow; Yang An; Mark J West; Barbara J Crain; Juan C Troncoso
Neuronal hypertrophy in asymptomatic Alzheimer disease.
Journal of neuropathology and experimental neurology 2008;67(6):578-89.
2008: Gay Rudow; Richard J O'Brien; Alena V Savonenko; Susan M Resnick; Alan B Zonderman; Olga Pletnikova; Laura Marsh; Ted M Dawson; Barbara J Crain; Mark J West; Juan C Troncoso
Morphometry of the human substantia nigra in ageing and Parkinson's disease.
Acta neuropathologica 2008;115(4):461-70.
2007: Miguel Angel Riudavets; Diego Iacono; Susan M Resnick; Richard J O'Brien; Alan B Zonderman; Lee J Martin; Gay Rudow; Olga Pletnikova; Juan C Troncoso
Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons.
Neurobiology of aging 2007;28(10):1484-92.
2007: Melissa D Morgan; Michelle M Mielke; Richard J O'Brien; Juan C Troncoso; Alan B Zonderman; Constantine G Lyketsos
Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA).
Alzheimer disease and associated disorders 2007;21(3):199-204.
2007: Kenneth M Rosen; Abhay Moghekar; Richard J O'Brien
Activity dependent localization of synaptic NMDA receptors in spinal neurons.
Molecular and cellular neurosciences 2007;34(4):578-91.
2006: Ira Driscoll; Susan M Resnick; Juan C Troncoso; Yang An; Richard J O'Brien; Alan B Zonderman
Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly.
Annals of neurology 2006;60(6):688-95.
2006: A Gamaldo; Abhay Moghekar; S Kilada; Susan M Resnick; Alan B Zonderman; Richard J O'Brien
Effect of a clinical stroke on the risk of dementia in a prospective cohort.
Neurology 2006;67(8):1363-9.
2005: Irina Mikolaenko; Olga Pletnikova; Claudia H Kawas; Richard J O'Brien; Susan M Resnick; Barbara J Crain; Juan C Troncoso
Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).
Journal of neuropathology and experimental neurology 2005;64(2):156-62.
2005: Sandy Kilada; Alyssa Gamaldo; Elizabeth A Grant; Abhay Moghekar; John C Morris; Richard J O'Brien
Brief screening tests for the diagnosis of dementia: comparison with the mini-mental state exam.
Alzheimer disease and associated disorders 2005;19(1):8-16.
2004: Ruifa Mi; Gek-Ming Sia; Kenneth M Rosen; Xiaopei Tang; Abhay Moghekar; John L Black; Maureen McEnery; Richard Huganir; Richard J O'Brien
AMPA receptor-dependent clustering of synaptic NMDA receptors is mediated by Stargazin and NR2A/B in spinal neurons and hippocampal interneurons.
Neuron 2004;44(2):335-49.
2004: Mir Ahamed Hossain; Juliet C Russell; Richard J O'Brien; John Laterra
Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(17):4187-96.
2004: Stephanie Schlickum; Abhay Moghekar; Jeremy C Simpson; Cordula Steglich; Richard J O'Brien; Andreas Winterpacht; Sabine Endele
LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein.
Genomics 2004;83(2):254-61.
2003: Desheng Xu; Carsten Hopf; Radhika Reddy; Richard Cho; Liping Guo; Anthony A Lanahan; Ronald S Petralia; Robert Wenthold; Richard J O'Brien; Paul F Worley
Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity.
Neuron 2003;39(3):513-28.
2002: Ruifa Mi; Xiaopei Tang; Ralph Sutter; Desheng Xu; Paul F Worley; Richard J O'Brien
Differing mechanisms for glutamate receptor aggregation on dendritic spines and shafts in cultured hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(17):7606-16.
2002: Richard J O'Brien; Desheng Xu; Ruifa Mi; Xiaopei Tang; Carsten Hopf; Paul F Worley
Synaptically targeted narp plays an essential role in the aggregation of AMPA receptors at excitatory synapses in cultured spinal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(11):4487-98.
2001: Vinay Chaudhry; David R Cornblath; John W Griffin; Richard J O'Brien; Daniel B Drachman
Mycophenolate mofetil: a safe and promising immunosuppressant in neuromuscular diseases.
Neurology 2001;56(1):94-6.
1999: Richard J O'Brien; Desheng Xu; Ronald S Petralia; Oswald Steward; Richard Huganir; Paul F Worley
Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp.
Neuron 1999;23(2):309-23.
1999: O Bar-Peled; Richard J O'Brien; J H Morrison; Jeffrey rothstein
Cultured motor neurons possess calcium-permeable AMPA/kainate receptors.
Neuroreport 1999;10(4):855-9.
1999: D Liao; X Zhang; Richard J O'Brien; Michael D Ehlers; Richard Huganir
Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons.
Nature neuroscience 1999;2(1):37-43.
1998: Richard J O'Brien; S Kamboj; Michael D Ehlers; Kenneth M Rosen; G D Fischbach; Richard Huganir
Activity-dependent modulation of synaptic AMPA receptor accumulation.
Neuron 1998;21(5):1067-78.
1998: Richard J O'Brien; L F Lau; Richard Huganir
Molecular mechanisms of glutamate receptor clustering at excitatory synapses.
Current opinion in neurobiology 1998;8(3):364-9.
1998: Michael D Ehlers; Eric T Fung; Richard J O'Brien; Richard Huganir
Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(2):720-30.
1997: Alex Mammen; Richard Huganir; Richard J O'Brien
Redistribution and stabilization of cell surface glutamate receptors during synapse formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(19):7351-8.
1997: Richard J O'Brien; Alex Mammen; Seth Blackshaw; Michael D Ehlers; Jeffrey rothstein; Richard Huganir
The development of excitatory synapses in cultured spinal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(19):7339-50.
1997: P R Brakeman; Anthony A Lanahan; Richard J O'Brien; K Roche; Carol A Barnes; Richard Huganir; Paul F Worley
Homer: a protein that selectively binds metabotropic glutamate receptors.
Nature 1997;386(6622):284-8.
1997: H Dong; Richard J O'Brien; Eric T Fung; Anthony A Lanahan; Paul F Worley; Richard Huganir
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors.
Nature 1997;386(6622):279-84.
1996: Katherine W Roche; Richard J O'Brien; Alex Mammen; J Bernhardt; Richard Huganir
Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit.
Neuron 1996;16(6):1179-88.
1986: Richard J O'Brien; G D Fischbach
Isolation of embryonic chick motoneurons and their survival in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(11):3265-74.
1986: Richard J O'Brien; G D Fischbach
Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(11):3290-6.
1986: Richard J O'Brien; G D Fischbach
Excitatory synaptic transmission between interneurons and motoneurons in chick spinal cord cell cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(11):3284-9.
1986: Richard J O'Brien; G D Fischbach
Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(11):3275-83.
1985: L W Role; V R Matossian; Richard J O'Brien; G D Fischbach
On the mechanism of acetylcholine receptor accumulation at newly formed synapses on chick myotubes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1985;5(8):2197-204.