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Richard O'Brien

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Lynley D Pound; Masakazu Shiota; Yingda Wang; Tracy P O'Brien; James K Oeser; Prasanna K Dadi; Chandler J Faulman; John C Hutton; David A Jacobson; Owen P McGuinness; Richard M O'Brien
G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion.
Lynley D Pound; David R Powell; Suparna A Sarkar; Melanie K Shadoan; Masakazu Shiota; Alessandro Ustione; Jay A Walters; Prasanna K Dadi; John C Hutton; David A Jacobson; Catherine E Lee; Owen P McGuinness; David W Piston; Richard M O'Brien
The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background.
Lynley D Pound; Suparna A Sarkar; Yingda Wang; James K Oeser; Stéphane Cauchi; philippe froguel; John C Hutton; Catherine E Lee; Richard M O'Brien
Characterization of the human SLC30A8 promoter and intronic enhancer.

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All Publications

2013: Lynley D Pound; Masakazu Shiota; Yingda Wang; Tracy P O'Brien; James K Oeser; Prasanna K Dadi; Chandler J Faulman; John C Hutton; David A Jacobson; Owen P McGuinness; Richard M O'Brien
G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion.
Diabetes 2013;62(5):1547-56.
2012: Lynley D Pound; David R Powell; Suparna A Sarkar; Melanie K Shadoan; Masakazu Shiota; Alessandro Ustione; Jay A Walters; Prasanna K Dadi; John C Hutton; David A Jacobson; Catherine E Lee; Owen P McGuinness; David W Piston; Richard M O'Brien
The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background.
PloS one 2012;7(7):e40972.
2011: Lynley D Pound; Suparna A Sarkar; Yingda Wang; James K Oeser; Stéphane Cauchi; philippe froguel; John C Hutton; Catherine E Lee; Richard M O'Brien
Characterization of the human SLC30A8 promoter and intronic enhancer.
Journal of molecular endocrinology 2011;47(3):251-9.
2011: James K Oeser; Vrajesh V Parekh; Lynley D Pound; Suparna A Sarkar; Luc Van Kaer; Yingda Wang; Randall Wong; John C Hutton; Naresh K Jegadeesh; Catherine E Lee; Richard M O'Brien
Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice.
Diabetes 2011;60(11):2922-7.
2011: Lynley D Pound; Yan Hang; Suparna A Sarkar; Yingda Wang; Laurel A Milam; James K Oeser; Richard L Printz; Catherine E Lee; Roland Stein; John C Hutton; Richard M O'Brien
The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer.
The Biochemical journal 2011;433(1):95-105.
2009: Lynley D Pound; Suparna A Sarkar; Richard K P Benninger; Yingda Wang; Adisak Suwanichkul; Melanie K Shadoan; Richard L Printz; James K Oeser; Catherine E Lee; David W Piston; Owen P McGuinness; John C Hutton; David R Powell; Richard M O'Brien
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.
The Biochemical journal 2009;421(3):371-6.
2008: Cyrus C Martin; Brian P Flemming; Yingda Wang; James K Oeser; Richard M O'Brien
Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression.
Journal of molecular endocrinology 2008;41(5):315-28.
2008: M M Schilling; James K Oeser; J K Chandy; B P Flemming; S R Allen; Richard M O'Brien
Sequence variation between the mouse and human glucose-6-phosphatase catalytic subunit gene promoters results in differential activation by peroxisome proliferator activated receptor gamma coactivator-1alpha.
Diabetologia 2008;51(8):1505-14.
2008: Yingda Wang; Brian P Flemming; Cyrus C Martin; Shelley R Allen; Jay Walters; James K Oeser; John C Hutton; Richard M O'Brien
Long-range enhancers are required to maintain expression of the autoantigen islet-specific glucose-6-phosphatase catalytic subunit-related protein in adult mouse islets in vivo.
Diabetes 2008;57(1):133-41.
2007: Yingda Wang; Cyrus C Martin; James K Oeser; S Sarkar; Owen P McGuinness; John C Hutton; Richard M O'Brien
Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype.
Diabetologia 2007;50(4):774-8.
2006: Yingda Wang; James K Oeser; Chunmei Yang; Suparna Sarkar; Seija I Hackl; Alyssa H Hasty; Owen P McGuinness; William Paradee; John C Hutton; David R Powell; Richard M O'Brien
Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.
The Journal of biological chemistry 2006;281(52):39982-9.
2006: Hiroshi Onuma; Beth T Vander Kooi; Jared N Boustead; James K Oeser; Richard M O'Brien
Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin.
Molecular endocrinology (Baltimore, Md.) 2006;20(11):2831-47.
2006: Marcia M Schilling; James K Oeser; Jared N Boustead; Brian P Flemming; Richard M O'Brien
Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection.
Nature 2006;443(7111):E10-1.
2005: Beth T Vander Kooi; Hiroshi Onuma; James K Oeser; Christina A Svitek; Shelley R Allen; Craig W Vander Kooi; Walter J Chazin; Richard M O'Brien
The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements.
Molecular endocrinology (Baltimore, Md.) 2005;19(12):3001-22.
2004: Cyrus C Martin; James K Oeser; Richard M O'Brien
Differential regulation of islet-specific glucose-6-phosphatase catalytic subunit-related protein gene transcription by Pax-6 and Pdx-1.
The Journal of biological chemistry 2004;279(33):34277-89.
2004: Julio E Ayala; Jared N Boustead; SC Chapman; Christina A Svitek; James K Oeser; R B Robey; Richard M O'Brien
Insulin-mediated activation of activator protein-1 through the mitogen-activated protein kinase pathway stimulates collagenase-1 gene transcription in the MES 13 mesangial cell line.
Journal of molecular endocrinology 2004;33(1):263-80.
2004: Claudia Frigeri; Cyrus C Martin; Christina A Svitek; James K Oeser; John C Hutton; Maureen Gannon; Richard M O'Brien
The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo.
Diabetes 2004;53(7):1754-64.
2004: Lauri A Hornbuckle; Carrie A Everett; Cyrus C Martin; Stephanie S Gustavson; Christina A Svitek; James K Oeser; Doss W Neal; Alan D Cherrington; Richard M O'Brien
Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ.
American journal of physiology. Endocrinology and metabolism 2004;286(5):E795-808.
2004: Jared N Boustead; Cyrus C Martin; James K Oeser; Christina A Svitek; S I Hunter; John C Hutton; Richard M O'Brien
Identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein.
Journal of molecular endocrinology 2004;32(1):33-53.
2003: Cyrus C Martin; Christina A Svitek; James K Oeser; Eva Henderson; Roland Stein; Richard M O'Brien
Upstream stimulatory factor (USF) and neurogenic differentiation/beta-cell E box transactivator 2 (NeuroD/BETA2) contribute to islet-specific glucose-6-phosphatase catalytic-subunit-related protein (IGRP) gene expression.
The Biochemical journal 2003;371(Pt 3):675-86.
2003: Beth T Vander Kooi; Ryan S Streeper; Christina A Svitek; James K Oeser; David R Powell; Richard M O'Brien
The three insulin response sequences in the glucose-6-phosphatase catalytic subunit gene promoter are functionally distinct.
The Journal of biological chemistry 2003;278(14):11782-93.
2003: Jared N Boustead; Beth T Stadelmaier; Angela Eeds; Peter O Wiebe; Christina A Svitek; James K Oeser; Richard M O'Brien
Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells.
The Biochemical journal 2003;369(Pt 1):17-22.
2002: Cyrus C Martin; James K Oeser; Christina A Svitek; S I Hunter; John C Hutton; Richard M O'Brien
Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein.
Journal of molecular endocrinology 2002;29(2):205-22.
2002: Julio E Ayala; Ryan S Streeper; Christina A Svitek; Joshua K Goldman; James K Oeser; Richard M O'Brien
Accessory elements, flanking DNA sequence, and promoter context play key roles in determining the efficacy of insulin and phorbol ester signaling through the malic enzyme and collagenase-1 AP-1 motifs.
The Journal of biological chemistry 2002;277(31):27935-44.
2001: Lauri A Hornbuckle; Dale S Edgerton; Julio E Ayala; Christina A Svitek; James K Oeser; Doss W Neal; Sylvain Cardin; Alan D Cherrington; Richard M O'Brien
Selective tonic inhibition of G-6-Pase catalytic subunit, but not G-6-P transporter, gene expression by insulin in vivo.
American journal of physiology. Endocrinology and metabolism 2001;281(4):E713-25.
2001: Richard M O'Brien; Ryan S Streeper; Julio E Ayala; Beth T Stadelmaier; Lauri A Hornbuckle
Insulin-regulated gene expression.
Biochemical Society transactions 2001;29(Pt 4):552-8.
2001: Cyrus C Martin; Larry J Bischof; B Bergman; Lauri A Hornbuckle; C Hilliker; C Frigeri; D Wahl; Christina A Svitek; R Wong; Joshua K Goldman; James K Oeser; frederic lepretre; philippe froguel; Richard M O'Brien; John C Hutton
Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes.
The Journal of biological chemistry 2001;276(27):25197-207.
2001: Ryan S Streeper; Lauri A Hornbuckle; Christina A Svitek; Joshua K Goldman; James K Oeser; Richard M O'Brien
Protein kinase A phosphorylates hepatocyte nuclear factor-6 and stimulates glucose-6-phosphatase catalytic subunit gene transcription.
The Journal of biological chemistry 2001;276(22):19111-8.
2001: Larry J Bischof; Cyrus C Martin; Christina A Svitek; Beth T Stadelmaier; Lauri A Hornbuckle; Joshua K Goldman; James K Oeser; John C Hutton; Richard M O'Brien
Characterization of the mouse islet-specific glucose-6-phosphatase catalytic subunit-related protein gene promoter by in situ footprinting: correlation with fusion gene expression in the islet-derived betaTC-3 and hamster insulinoma tumor cell lines.
Diabetes 2001;50(3):502-14.
2000: Ryan S Streeper; Christina A Svitek; Joshua K Goldman; Richard M O'Brien
Differential role of hepatocyte nuclear factor-1 in the regulation of glucose-6-phosphatase catalytic subunit gene transcription by cAMP in liver- and kidney-derived cell lines.
The Journal of biological chemistry 2000;275(16):12108-18.
1999: Julio E Ayala; Ryan S Streeper; Jay S Desgrosellier; S K Durham; Adisak Suwanichkul; Christina A Svitek; Joshua K Goldman; F G Barr; David R Powell; Richard M O'Brien
Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.
Diabetes 1999;48(9):1885-9.
1999: SC Chapman; Julio E Ayala; Ryan S Streeper; Ainsley A Culbert; Erin M Eaton; Christina A Svitek; Joshua K Goldman; J M Tavar; Richard M O'Brien
Multiple promoter elements are required for the stimulatory effect of insulin on human collagenase-1 gene transcription. Selective effects on activator protein-1 expression may explain the quantitative difference in insulin and phorbol ester action.
The Journal of biological chemistry 1999;274(26):18625-34.
1999: Daniel H Ebert; Larry J Bischof; Ryan S Streeper; SC Chapman; Christina A Svitek; Joshua K Goldman; Clayton E Mathews; Edward H Leiter; John C Hutton; Richard M O'Brien
Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene.
Diabetes 1999;48(3):543-51.
1999: Susan D Arden; Tobias R Zahn; S Steegers; S Webb; B Bergman; Richard M O'Brien; John C Hutton
Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein.
Diabetes 1999;48(3):531-42.
1998: Ryan S Streeper; SC Chapman; Julio E Ayala; Christina A Svitek; Joshua K Goldman; A Cave; Richard M O'Brien
A phorbol ester-insensitive AP-1 motif mediates the stimulatory effect of insulin on rat malic enzyme gene transcription.
Molecular endocrinology (Baltimore, Md.) 1998;12(11):1778-91.
1998: M Dickens; Christina A Svitek; Ainsley A Culbert; Richard M O'Brien; Jeremy M Tavaré
Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin.
The Journal of biological chemistry 1998;273(32):20144-9.
1998: Ryan S Streeper; Erin M Eaton; Daniel H Ebert; SC Chapman; Christina A Svitek; Richard M O'Brien
Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9208-13.
1997: Ryan S Streeper; Christina A Svitek; S Chapman; Linda E Greenbaum; Rebecca Taub; Richard M O'Brien
A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin.
The Journal of biological chemistry 1997;272(18):11698-701.
1996: JC Wang; P E Strömstedt; Richard M O'Brien; Daryl K Granner
Hepatic nuclear factor 3 is an accessory factor required for the stimulation of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids.
Molecular endocrinology (Baltimore, Md.) 1996;10(7):794-800.
1996: Calum Sutherland; Richard M O'Brien; Daryl K Granner
New connections in the regulation of PEPCK gene expression by insulin.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1336):191-9.
1996: D S Ludwig; Antonio Vidal-Puig; Richard M O'Brien; Richard L Printz; D K Granner; D E Moller; Jeffrey S Flier
Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1996;81(2):503-6.
1995: Richard M O'Brien; Richard L Printz; N Halmi; J J Tiesinga; Daryl K Granner
Structural and functional analysis of the human phosphoenolpyruvate carboxykinase gene promoter.
Biochimica et biophysica acta 1995;1264(3):284-8.
1995: Richard M O'Brien; N Halmi; P E Stromstedt; Richard L Printz; Daryl K Granner
Expression cloning of a zinc-finger cyclic AMP-response-element-binding protein.
The Biochemical journal 1995;312 ( Pt 1)():17-21.
1995: Calum Sutherland; Richard M O'Brien; Daryl K Granner
Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin. Dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression.
The Journal of biological chemistry 1995;270(26):15501-6.
1995: Richard M O'Brien; E L Noisin; Adisak Suwanichkul; T Yamasaki; Peter C Lucas; JC Wang; David R Powell; Daryl K Granner
Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes.
Molecular and cellular biology 1995;15(3):1747-58.
1994: Richard M O'Brien; Peter C Lucas; T Yamasaki; E L Noisin; Daryl K Granner
Potential convergence of insulin and cAMP signal transduction systems at the phosphoenolpyruvate carboxykinase (PEPCK) gene promoter through CCAAT/enhancer binding protein (C/EBP).
The Journal of biological chemistry 1994;269(48):30419-28.
1994: Richard M O'Brien; E L Noisin; Daryl K Granner
Comparison of the effects of insulin and okadaic acid on phosphoenolpyruvate carboxykinase gene expression.
The Biochemical journal 1994;303 ( Pt 3)():737-42.
1993: S Faber; Richard M O'Brien; E Imai; Daryl K Granner; Roger Chalkley
Dynamic aspects of DNA/protein interactions in the transcriptional initiation complex and the hormone-responsive domains of the phosphoenolpyruvate carboxykinase promoter in vivo.
The Journal of biological chemistry 1993;268(33):24976-85.
1993: Richard M O'Brien; Peter C Lucas; T Yamasaki; Daryl K Granner
The physiological importance of insulin regulated gene expression: metabolic and molecular studies.
Advances in second messenger and phosphoprotein research 1993;28():245-53.
1992: Richard M O'Brien; Peter C Lucas; T Yamasaki; M T Bonovich; Claude Forest; Daryl K Granner
Insulin and phorbol esters act through the same DNA element to inhibit phosphoenolpyruvate carboxykinase gene transcription.
Biochemical Society transactions 1992;20(3):686-90.
1992: Daryl K Granner; Richard M O'Brien
Molecular physiology and genetics of NIDDM. Importance of metabolic staging.
Diabetes care 1992;15(3):369-95.
1991: Richard M O'Brien; Daryl K Granner
Regulation of gene expression by insulin.
The Biochemical journal 1991;278 ( Pt 3)():609-19.
1991: Richard M O'Brien; M T Bonovich; Claude Forest; Daryl K Granner
Signal transduction convergence: phorbol esters and insulin inhibit phosphoenolpyruvate carboxykinase gene transcription through the same 10-base-pair sequence.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6580-4.
1991: Peter C Lucas; Richard M O'Brien; J A Mitchell; C M Davis; E Imai; B M Forman; Herbert H Samuels; Daryl K Granner
A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2184-8.
1990: Claude Forest; Richard M O'Brien; Peter C Lucas; Mark Magnuson; Daryl K Granner
Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence.
Molecular endocrinology (Baltimore, Md.) 1990;4(9):1302-10.
1990: Richard M O'Brien; Peter C Lucas; Claude Forest; Mark Magnuson; Daryl K Granner
Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription.
Science (New York, N.Y.) 1990;249(4968):533-7.
1990: Richard M O'Brien; Daryl K Granner
PEPCK gene as model of inhibitory effects of insulin on gene transcription.
Diabetes care 1990;13(3):327-39.
1988: Jeremy M Tavaré; Richard M O'Brien; K Siddle; Richard M Denton
Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mapping.
The Biochemical journal 1988;253(3):783-8.