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Richard O'Brien

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.8 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
23
Oeser, James
22
Svitek, Christina
18
Granner, Daryl
11
Hutton, John
11
Martin, Cyrus
11
Streeper, Ryan
9
Goldman, Joshua
7
Ayala, Julio
7
Lucas, Peter
6
Hornbuckle, Lauri
5
Boustead, Jared
5
Chapman, SC
5
Wang, Yingda
5
Powell, David
4
Printz, Richard

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Publications

TOP 3
Pound Lynley D; Sarkar Suparna A; Benninger Richard K P; Wang Yingda; Suwanichkul Adisak; Shadoan Melanie K; Printz Richard L; Oeser James K; Lee Catherine E; Piston David W; McGuinness Owen P; Hutton John C; Powell David R; O'Brien Richard M
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.
Martin Cyrus C; Flemming Brian P; Wang Yingda; Oeser James K; O'Brien Richard M
Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression.
Schilling M M; Oeser J K; Chandy J K; Flemming B P; Allen S R; O'Brien R M
Sequence variation between the mouse and human glucose-6-phosphatase catalytic subunit gene promoters results in differential activation by peroxisome proliferator activated receptor gamma coactivator-1alpha.

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All Publications

2009: Pound Lynley D; Sarkar Suparna A; Benninger Richard K P; Wang Yingda; Suwanichkul Adisak; Shadoan Melanie K; Printz Richard L; Oeser James K; Lee Catherine E; Piston David W; McGuinness Owen P; Hutton John C; Powell David R; O'Brien Richard M
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.
The Biochemical journal 2009;421(3):371-6.
2008: Martin Cyrus C; Flemming Brian P; Wang Yingda; Oeser James K; O'Brien Richard M
Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression.
Journal of molecular endocrinology 2008;41(5):315-28.
2008: Schilling M M; Oeser J K; Chandy J K; Flemming B P; Allen S R; O'Brien R M
Sequence variation between the mouse and human glucose-6-phosphatase catalytic subunit gene promoters results in differential activation by peroxisome proliferator activated receptor gamma coactivator-1alpha.
Diabetologia 2008;51(8):1505-14.
2008: Wang Yingda; Flemming Brian P; Martin Cyrus C; Allen Shelley R; Walters Jay; Oeser James K; Hutton John C; O'Brien Richard M
Long-range enhancers are required to maintain expression of the autoantigen islet-specific glucose-6-phosphatase catalytic subunit-related protein in adult mouse islets in vivo.
Diabetes 2008;57(1):133-41.
2007: Wang Y; Martin C C; Oeser J K; Sarkar S; McGuinness O P; Hutton J C; O'Brien R M
Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype.
Diabetologia 2007;50(4):774-8.
2006: Wang Yingda; Oeser James K; Yang Chunmei; Sarkar Suparna; Hackl Seija I; Hasty Alyssa H; McGuinness Owen P; Paradee William; Hutton John C; Powell David R; O'Brien Richard M
Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.
The Journal of biological chemistry 2006;281(52):39982-9.
2006: Onuma Hiroshi; Vander Kooi Beth T; Boustead Jared N; Oeser James K; O'Brien Richard M
Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin.
Molecular endocrinology (Baltimore, Md.) 2006;20(11):2831-47.
2006: Schilling Marcia M; Oeser James K; Boustead Jared N; Flemming Brian P; O'Brien Richard M
Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection.
Nature 2006;443(7111):E10-1.
2005: Vander Kooi Beth T; Onuma Hiroshi; Oeser James K; Svitek Christina A; Allen Shelley R; Vander Kooi Craig W; Chazin Walter J; O'Brien Richard M
The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements.
Molecular endocrinology (Baltimore, Md.) 2005;19(12):3001-22.
2004: Ayala J E; Boustead J N; Chapman S C; Svitek C A; Oeser J K; Robey R B; O'Brien R M
Insulin-mediated activation of activator protein-1 through the mitogen-activated protein kinase pathway stimulates collagenase-1 gene transcription in the MES 13 mesangial cell line.
Journal of molecular endocrinology 2004;33(1):263-80.
2004: Martin Cyrus C; Oeser James K; O'Brien Richard M
Differential regulation of islet-specific glucose-6-phosphatase catalytic subunit-related protein gene transcription by Pax-6 and Pdx-1.
The Journal of biological chemistry 2004;279(33):34277-89.
2004: Frigeri Claudia; Martin Cyrus C; Svitek Christina A; Oeser James K; Hutton John C; Gannon Maureen; O'Brien Richard M
The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo.
Diabetes 2004;53(7):1754-64.
2004: Hornbuckle Lauri A; Everett Carrie A; Martin Cyrus C; Gustavson Stephanie S; Svitek Christina A; Oeser James K; Neal Doss W; Cherrington Alan D; O'Brien Richard M
Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ.
American journal of physiology. Endocrinology and metabolism 2004;286(5):E795-808.
2004: Boustead J N; Martin C C; Oeser J K; Svitek C A; Hunter S I; Hutton J C; O'Brien R M
Identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein.
Journal of molecular endocrinology 2004;32(1):33-53.
2003: Martin Cyrus C; Svitek Christina A; Oeser James K; Henderson Eva; Stein Roland; O'Brien Richard M
Upstream stimulatory factor (USF) and neurogenic differentiation/beta-cell E box transactivator 2 (NeuroD/BETA2) contribute to islet-specific glucose-6-phosphatase catalytic-subunit-related protein (IGRP) gene expression.
The Biochemical journal 2003;371(Pt 3):675-86.
2003: Vander Kooi Beth T; Streeper Ryan S; Svitek Christina A; Oeser James K; Powell David R; O'Brien Richard M
The three insulin response sequences in the glucose-6-phosphatase catalytic subunit gene promoter are functionally distinct.
The Journal of biological chemistry 2003;278(14):11782-93.
2003: Boustead Jared N; Stadelmaier Beth T; Eeds Angela M; Wiebe Peter O; Svitek Christina A; Oeser James K; O'Brien Richard M
Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells.
The Biochemical journal 2003;369(Pt 1):17-22.
2002: Martin C C; Oeser J K; Svitek C A; Hunter S I; Hutton J C; O'Brien R M
Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein.
Journal of molecular endocrinology 2002;29(2):205-22.
2002: Ayala Julio E; Streeper Ryan S; Svitek Christina A; Goldman Joshua K; Oeser James K; O'Brien Richard M
Accessory elements, flanking DNA sequence, and promoter context play key roles in determining the efficacy of insulin and phorbol ester signaling through the malic enzyme and collagenase-1 AP-1 motifs.
The Journal of biological chemistry 2002;277(31):27935-44.
2001: Hornbuckle L A; Edgerton D S; Ayala J E; Svitek C A; Oeser J K; Neal D W; Cardin S; Cherrington A D; O'Brien R M
Selective tonic inhibition of G-6-Pase catalytic subunit, but not G-6-P transporter, gene expression by insulin in vivo.
American journal of physiology. Endocrinology and metabolism 2001;281(4):E713-25.
2001: O'Brien R M; Streeper R S; Ayala J E; Stadelmaier B T; Hornbuckle L A
Insulin-regulated gene expression.
Biochemical Society transactions 2001;29(Pt 4):552-8.
2001: Martin C C; Bischof L J; Bergman B; Hornbuckle L A; Hilliker C; Frigeri C; Wahl D; Svitek C A; Wong R; Goldman J K; Oeser J K; Leprêtre F; Froguel P; O'Brien R M; Hutton J C
Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes.
The Journal of biological chemistry 2001;276(27):25197-207.
2001: Streeper R S; Hornbuckle L A; Svitek C A; Goldman J K; Oeser J K; O'Brien R M
Protein kinase A phosphorylates hepatocyte nuclear factor-6 and stimulates glucose-6-phosphatase catalytic subunit gene transcription.
The Journal of biological chemistry 2001;276(22):19111-8.
2001: Bischof L J; Martin C C; Svitek C A; Stadelmaier B T; Hornbuckle L A; Goldman J K; Oeser J K; Hutton J C; O'Brien R M
Characterization of the mouse islet-specific glucose-6-phosphatase catalytic subunit-related protein gene promoter by in situ footprinting: correlation with fusion gene expression in the islet-derived betaTC-3 and hamster insulinoma tumor cell lines.
Diabetes 2001;50(3):502-14.
2000: Streeper R S; Svitek C A; Goldman J K; O'Brien R M
Differential role of hepatocyte nuclear factor-1 in the regulation of glucose-6-phosphatase catalytic subunit gene transcription by cAMP in liver- and kidney-derived cell lines.
The Journal of biological chemistry 2000;275(16):12108-18.
1999: Ayala J E; Streeper R S; Desgrosellier J S; Durham S K; Suwanichkul A; Svitek C A; Goldman J K; Barr F G; Powell D R; O'Brien R M
Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.
Diabetes 1999;48(9):1885-9.
1999: Chapman S C; Ayala J E; Streeper R S; Culbert A A; Eaton E M; Svitek C A; Goldman J K; Tavar J M; O'Brien R M
Multiple promoter elements are required for the stimulatory effect of insulin on human collagenase-1 gene transcription. Selective effects on activator protein-1 expression may explain the quantitative difference in insulin and phorbol ester action.
The Journal of biological chemistry 1999;274(26):18625-34.
1999: Ebert D H; Bischof L J; Streeper R S; Chapman S C; Svitek C A; Goldman J K; Mathews C E; Leiter E H; Hutton J C; O'Brien R M
Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene.
Diabetes 1999;48(3):543-51.
1999: Arden S D; Zahn T; Steegers S; Webb S; Bergman B; O'Brien R M; Hutton J C
Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein.
Diabetes 1999;48(3):531-42.
1998: Streeper R S; Chapman S C; Ayala J E; Svitek C A; Goldman J K; Cave A; O'Brien R M
A phorbol ester-insensitive AP-1 motif mediates the stimulatory effect of insulin on rat malic enzyme gene transcription.
Molecular endocrinology (Baltimore, Md.) 1998;12(11):1778-91.
1998: Streeper R S; Eaton E M; Ebert D H; Chapman S C; Svitek C A; O'Brien R M
Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9208-13.
1998: Dickens M; Svitek C A; Culbert A A; O'Brien R M; Tavaré J M
Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin.
The Journal of biological chemistry 1998;273(32):20144-9.
1997: Streeper R S; Svitek C A; Chapman S; Greenbaum L E; Taub R; O'Brien R M
A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin.
The Journal of biological chemistry 1997;272(18):11698-701.
1996: Wang J C; Strömstedt P E; O'Brien R M; Granner D K
Hepatic nuclear factor 3 is an accessory factor required for the stimulation of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids.
Molecular endocrinology (Baltimore, Md.) 1996;10(7):794-800.
1996: Sutherland C; O'Brien R M; Granner D K
New connections in the regulation of PEPCK gene expression by insulin.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1336):191-9.
1996: Ludwig D S; Vidal-Puig A; O'Brien R M; Printz R L; Granner D K; Moller D E; Flier J S
Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1996;81(2):503-6.
1995: O'Brien R M; Printz R L; Halmi N; Tiesinga J J; Granner D K
Structural and functional analysis of the human phosphoenolpyruvate carboxykinase gene promoter.
Biochimica et biophysica acta 1995;1264(3):284-8.
1995: O'Brien R M; Halmi N; Stromstedt P E; Printz R L; Granner D K
Expression cloning of a zinc-finger cyclic AMP-response-element-binding protein.
The Biochemical journal 1995;312 ( Pt 1)():17-21.
1995: Sutherland C; O'Brien R M; Granner D K
Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin. Dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression.
The Journal of biological chemistry 1995;270(26):15501-6.
1995: O'Brien R M; Noisin E L; Suwanichkul A; Yamasaki T; Lucas P C; Wang J C; Powell D R; Granner D K
Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes.
Molecular and cellular biology 1995;15(3):1747-58.
1994: O'Brien R M; Lucas P C; Yamasaki T; Noisin E L; Granner D K
Potential convergence of insulin and cAMP signal transduction systems at the phosphoenolpyruvate carboxykinase (PEPCK) gene promoter through CCAAT/enhancer binding protein (C/EBP).
The Journal of biological chemistry 1994;269(48):30419-28.
1994: O'Brien R M; Noisin E L; Granner D K
Comparison of the effects of insulin and okadaic acid on phosphoenolpyruvate carboxykinase gene expression.
The Biochemical journal 1994;303 ( Pt 3)():737-42.
1993: Faber S; O'Brien R M; Imai E; Granner D K; Chalkley R
Dynamic aspects of DNA/protein interactions in the transcriptional initiation complex and the hormone-responsive domains of the phosphoenolpyruvate carboxykinase promoter in vivo.
The Journal of biological chemistry 1993;268(33):24976-85.
1993: O'Brien R M; Lucas P C; Yamasaki T; Granner D K
The physiological importance of insulin regulated gene expression: metabolic and molecular studies.
Advances in second messenger and phosphoprotein research 1993;28():245-53.
1992: O'Brien R M; Lucas P C; Yamasaki T; Bonovich M T; Forest C D; Granner D K
Insulin and phorbol esters act through the same DNA element to inhibit phosphoenolpyruvate carboxykinase gene transcription.
Biochemical Society transactions 1992;20(3):686-90.
1992: Granner D K; O'Brien R M
Molecular physiology and genetics of NIDDM. Importance of metabolic staging.
Diabetes care 1992;15(3):369-95.
1991: O'Brien R M; Granner D K
Regulation of gene expression by insulin.
The Biochemical journal 1991;278 ( Pt 3)():609-19.
1991: O'Brien R M; Bonovich M T; Forest C D; Granner D K
Signal transduction convergence: phorbol esters and insulin inhibit phosphoenolpyruvate carboxykinase gene transcription through the same 10-base-pair sequence.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6580-4.
1991: Lucas P C; O'Brien R M; Mitchell J A; Davis C M; Imai E; Forman B M; Samuels H H; Granner D K
A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2184-8.
1990: Forest C D; O'Brien R M; Lucas P C; Magnuson M A; Granner D K
Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence.
Molecular endocrinology (Baltimore, Md.) 1990;4(9):1302-10.
1990: O'Brien R M; Lucas P C; Forest C D; Magnuson M A; Granner D K
Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription.
Science (New York, N.Y.) 1990;249(4968):533-7.
1990: O'Brien R M; Granner D K
PEPCK gene as model of inhibitory effects of insulin on gene transcription.
Diabetes care 1990;13(3):327-39.
1988: Tavaré J M; O'Brien R M; Siddle K; Denton R M
Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mapping.
The Biochemical journal 1988;253(3):783-8.

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