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Thomas O'Brien

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
11
Gilmour, Susan
10
Megosh, Louis
7
Civan, Mortimer
6
Peterson-Yantorno, Kim
6
Rosson, D
5
Boorman, David
5
Guo, Yongjun
4
Sawicki, Janet
4
Soler, Alejandro Peralta
4
Pegg, Anthony
4
Mullin, James
3
Robertson, Fredika
3
Guo, Yongjun
3
Helzlsouer, Kathy
3
Coleman, Catherine

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Publications

TOP 3
Burns Mark R; Graminski Gerard F; Weeks Reitha S; Chen Yan; O'Brien Thomas G
Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor.
Nelson Gail M; Ahlborn Gene J; Delker Don A; Kitchin Kirk T; O'Brien Thomas G; Chen Yan; Kohan Michael J; Roop Barbara C; Ward William O; Allen James W
Folate deficiency enhances arsenic effects on expression of genes involved in epidermal differentiation in transgenic K6/ODC mouse skin.
Wang Xiaojing; Feith David J; Welsh Pat; Coleman Catherine S; Lopez Christina; Woster Patrick M; O'Brien Thomas G; Pegg Anthony E
Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis.

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All Publications

2009: Burns Mark R; Graminski Gerard F; Weeks Reitha S; Chen Yan; O'Brien Thomas G
Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor.
Journal of medicinal chemistry 2009;52(7):1983-93.
2007: Nelson Gail M; Ahlborn Gene J; Delker Don A; Kitchin Kirk T; O'Brien Thomas G; Chen Yan; Kohan Michael J; Roop Barbara C; Ward William O; Allen James W
Folate deficiency enhances arsenic effects on expression of genes involved in epidermal differentiation in transgenic K6/ODC mouse skin.
Toxicology 2007;241(3):134-45.
2007: Wang Xiaojing; Feith David J; Welsh Pat; Coleman Catherine S; Lopez Christina; Woster Patrick M; O'Brien Thomas G; Pegg Anthony E
Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis.
Carcinogenesis 2007;28(11):2404-11.
2006: Chen Yan; Weeks Reitha S; Burns Mark R; Boorman David W; Klein-Szanto Andres; O'Brien Thomas G
Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2006;118(9):2344-9.
2005: George Kenneth; Iacobucci Audrey; Uitto Jessica; O'Brien Thomas G
Identification of an X-linked locus modifying mouse skin tumor susceptibility.
Molecular carcinogenesis 2005;44(3):212-8.
2005: Guo Yongjun; Cleveland John L; O'Brien Thomas G
Haploinsufficiency for odc modifies mouse skin tumor susceptibility.
Cancer research 2005;65(4):1146-9.
2005: Wallon U Margaretha; O'Brien Thomas G
Polyamines modulate carcinogen-induced mutagenesis in vivo.
Environmental and molecular mutagenesis 2005;45(1):62-9.
2004: O'Brien Thomas G; Guo Y; Visvanathan K; Sciulli J; McLaine M; Helzlsouer K J; Watkins-Bruner D
Differences in ornithine decarboxylase and androgen receptor allele frequencies among ethnic groups.
Molecular carcinogenesis 2004;41(2):120-123.
2004: Visvanathan Kala; Helzlsouer Kathy J; Boorman David W; Strickland Paul T; Hoffman Sandy C; Comstock George W; O'Brien Thomas G; Guo Yongjun
Association among an ornithine decarboxylase polymorphism, androgen receptor gene (CAG) repeat length and prostate cancer risk.
The Journal of urology 2004;171(2 Pt 1):652-5.
2003: Martinez Maria Elena; O'Brien Thomas G; Fultz Kimberly E; Babbar Naveen; Yerushalmi Hagit; Qu Ning; Guo Yongjun; Boorman David; Einspahr Janine; Alberts David S; Gerner Eugene W
Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7859-64.
2003: Pegg A E; Feith D J; Fong L Y Y; Coleman C S; O'Brien T G; Shantz L M
Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth.
Biochemical Society transactions 2003;31(2):356-60.
2002: Boorman D W; Guo Y; Visvanathan K; Helzlsouer K; O'Brien T G
Automated fragment analysis method for determining androgen receptor CAG repeat length.
BioTechniques 2002;33(1):140-3.
2002: Shantz Lisa M; Guo Yongjun; Sawicki Janet A; Pegg Anthony E; O'Brien Thomas G
Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation.
Carcinogenesis 2002;23(4):657-64.
2002: Megosh Louis C; Hu Juncai; George Ken; O'Brien Thomas G
Genetic control of polyamine-dependent susceptibility to skin tumorigenesis.
Genomics 2002;79(4):505-12.
2002: Coleman Catherine S; Pegg Anthony E; Megosh Louis C; Guo Yongjun; Sawicki Janet A; O'Brien Thomas G
Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis.
Carcinogenesis 2002;23(2):359-64.
2000: Guo Y; Harris R B; Rosson D; Boorman D; O'Brien T G
Functional analysis of human ornithine decarboxylase alleles.
Cancer research 2000;60(22):6314-7.
2000: Chen Y; Megosh L C; Gilmour S K; Sawicki J A; O'Brien T G
K6/ODC transgenic mice as a sensitive model for carcinogen identification.
Toxicology letters 2000;116(1-2):27-35.
1999: Guo Y; Zhao J; Sawicki J; Peralta Soler A; O'Brien T G
Conversion of C57Bl/6 mice from a tumor promotion-resistant to a -sensitive phenotype by enhanced ornithine decarboxylase expression.
Molecular carcinogenesis 1999;26(1):32-6.
1998: Megosh L; Halpern M; Farkash E; O'Brien T G
Analysis of ras gene mutational spectra in epidermal papillomas from K6/ODC transgenic mice.
Molecular carcinogenesis 1998;22(3):145-9.
1998: Rosson D; O'Brien T G
AP-1 activity affects the levels of induced erythroid and megakaryocytic differentiation of K562 cells.
Archives of biochemistry and biophysics 1998;352(2):298-305.
1998: Peralta Soler A; Gilliard G; Megosh L; George K; O'Brien T G
Polyamines regulate expression of the neoplastic phenotype in mouse skin.
Cancer research 1998;58(8):1654-9.
1997: O'Brien T G; Megosh L C; Gilliard G; Soler A P
Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin.
Cancer research 1997;57(13):2630-7.
1997: Rosson D; O'Brien T G; Kampherstein J A; Szallasi Z; Bogi K; Blumberg P M; Mullin J M
Protein kinase C-alpha activity modulates transepithelial permeability and cell junctions in the LLC-PK1 epithelial cell line.
The Journal of biological chemistry 1997;272(23):14950-3.
1996: Chalfant M L; Peterson-Yantorno K; O'Brien T G; Civan M M
Regulation of epithelial Na+ channels from M-1 cortical collecting duct cells.
The American journal of physiology 1996;271(4 Pt 2):F861-70.
1996: Guo Y; O'Brien T G
Restoration of responsiveness to phorbol ester by reconstitution of a functional Na/K/Cl cotransporter in cotransporter-deficient BALB/c 3T3 cells.
Molecular carcinogenesis 1996;17(1):35-40.
1996: Mullin J M; Soler A P; Laughlin K V; Kampherstein J A; Russo L M; Saladik D T; George K; Shurina R D; O'Brien T G
Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization.
Experimental cell research 1996;227(1):12-22.
1996: Chalfant M L; Civan J M; Peterson-Yantorno K; DiBona D R; O'Brien T G; Civan M M
Regulation of epithelial Na+ permeability by protein kinase C is tissue specific.
The Journal of membrane biology 1996;152(3):207-15.
1996: Soler A P; Gilliard G; Megosh L C; O'Brien T G
Modulation of murine hair follicle function by alterations in ornithine decarboxylase activity.
The Journal of investigative dermatology 1996;106(5):1108-13.
1996: Chalfant M L; O'Brien T G; Civan M M
Whole cell and unitary amiloride-sensitive sodium currents in M-1 mouse cortical collecting duct cells.
The American journal of physiology 1996;270(4 Pt 1):C998-1010.
1995: Megosh L; Gilmour S K; Rosson D; Soler A P; Blessing M; Sawicki J A; O'Brien T G
Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase.
Cancer research 1995;55(19):4205-9.
1995: Rosson D; O'Brien T G
Expression and modulation of protein kinase C isoforms in differentiation-competent and differentiation-resistant erythroleukemic cells.
Biochemical and biophysical research communications 1995;210(1):90-7.
1995: Rosson D; O'Brien T G
Constitutive c-myb expression in K562 cells inhibits induced erythroid differentiation but not tetradecanoyl phorbol acetate-induced megakaryocytic differentiation.
Molecular and cellular biology 1995;15(2):772-9.
1992: Mullin J M; Snock K V; Shurina R D; Noe J; George K; Misner L; Imaizumi S; O'Brien T G
Effects of acute vs. chronic phorbol ester exposure on transepithelial permeability and epithelial morphology.
Journal of cellular physiology 1992;152(1):35-47.
1992: Gilmour S K; Robertson F M; Megosh L; O'Connell S M; Mitchell J; O'Brien T G
Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate.
Carcinogenesis 1992;13(1):51-6.
1991: Sawicki J A; Impellizeri A; O'Brien T G
Effects of exogenous putrescine on murine preimplantation development in vitro.
Developmental biology 1991;148(2):620-4.
1991: Koza R A; Megosh L C; Palmieri M; O'Brien T G
Constitutively elevated levels of ornithine and polyamines in mouse epidermal papillomas.
Carcinogenesis 1991;12(9):1619-25.
1991: Civan M M; Oler A; Peterson-Yantorno K; George K; O'Brien T G
Ca(2+)-independent form of protein kinase C may regulate Na+ transport across frog skin.
The Journal of membrane biology 1991;121(1):37-50.
1990: Robertson F M; Gilmour S K; Conney A H; Huang M T; Beavis A J; Laskin J D; Hietala O A; O'Brien T G
Identification of epidermal cell subpopulations with increased ornithine decarboxylase activity following treatment of murine epidermis with 12-O-tetradecanoylphorbol-13-acetate.
Cancer research 1990;50(15):4741-6.
1990: Hietala O A; Yum K Y; Pilon J; O'Donnell K; Holroyde C P; Kline I; Reichard G A; Litwin S; Gilmour S K; O'Brien T G
Properties of ornithine decarboxylase in human colorectal adenocarcinomas.
Cancer research 1990;50(7):2088-94.
1990: Robertson F M; Gilmour S K; Beavis A J; O'Connell S M; Conney A H; Huang M T; Laskin J D; Hietala O A; O'Brien T G
Flow cytometric detection of ornithine decarboxylase activity in epidermal cell subpopulations.
Cytometry 1990;11(7):832-6.
1989: Civan M M; Peterson-Yantorno K; George K; O'Brien T G
Interactions of TPA and insulin on Na+ transport across frog skin.
The American journal of physiology 1989;256(3 Pt 1):C569-78.
1989: Gilmour S K; O'Brien T G
Regulation of ornithine decarboxylase gene expression in normal and transformed hamster embryo fibroblasts following stimulation by 12-O-tetradecanoylphorbol-13-acetate.
Carcinogenesis 1989;10(1):157-62.
1989: O'Brien T G; Dzubow L; Dlugosz A A; Gilmour S K; O'Donnell K; Hietala O
Regulation of ornithine decarboxylase in normal and neoplastic mouse and human epidermis.
Progress in clinical and biological research 1989;298():213-31.
1988: O'Brien T G; George K; Prettyman R
Protein kinase C and membrane transport: divergent responses of Na+/K+/Cl- cotransport and sugar transport to exogenous diacylglycerol.
Biochimica et biophysica acta 1988;945(1):41-50.
1988: O'Brien T G; O'Donnell K; Kruszewski F H; DiGiovanni J
Presence of a functionally altered ornithine decarboxylase activity in chrysarobin-promoted mouse epidermal papillomas.
Carcinogenesis 1988;9(11):2081-5.
1988: Hietala O; Dzubow L; Dlugosz A A; Pyle J A; Jenney F; Gilmour S K; O'Brien T G
Activation of human squamous cell carcinoma ornithine decarboxylase activity by guanosine triphosphate.
Cancer research 1988;48(5):1252-7.
1988: O'Brien T G; Prettyman R; George K S; Herschman H R
A phorbol ester-nonproliferative variant of Swiss 3T3 cells is deficient in Na+K+Cl- cotransport activity.
Journal of cellular physiology 1988;134(2):302-6.
1988: Civan M M; Peterson-Yantorno K; O'Brien T G
Insulin and phorbol ester stimulate conductive Na+ transport through a common pathway.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(3):963-7.
1987: Mullin J M; O'Brien T G
Spontaneous reversal of polarity of the voltage across LLC-PK1 renal epithelial cell sheets.
Journal of cellular physiology 1987;133(3):515-22.
1987: O'Brien T G; Hietala O; O'Donnell K; Holmes M
Activation of mouse epidermal tumor ornithine decarboxylase by GTP: evidence for different catalytic forms of the enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8927-31.
1987: Gilmour S K; Verma A K; Madara T; O'Brien T G
Regulation of ornithine decarboxylase gene expression in mouse epidermis and epidermal tumors during two-stage tumorigenesis.
Cancer research 1987;47(5):1221-5.
1987: O'Brien T G; Prettyman R
Phorbol esters and mitogenesis: comparison of the proliferative response of parental and Na+K+Cl- -cotransport-defective BALB/c 3T3 cells to 12-0-tetradecanoylphorbol-13-acetate.
Journal of cellular physiology 1987;130(3):377-81.
1987: Civan M M; Peterson-Yantorno K; O'Brien T G
Diacylglycerols stimulate short-circuit current across frog skin by increasing apical Na+ permeability.
The Journal of membrane biology 1987;97(3):193-204.
1986: O'Brien T G; Madara T; Pyle J A; Holmes M
Ornithine decarboxylase from mouse epidermis and epidermal papillomas: differences in enzymatic properties and structure.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9448-52.
1986: Mullin J M; O'Brien T G
Effects of tumor promoters on LLC-PK1 renal epithelial tight junctions and transepithelial fluxes.
The American journal of physiology 1986;251(4 Pt 1):C597-602.
1986: Gilmour S K; Aglow E; O'Brien T G
Heterogeneity of ornithine decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin and in epidermal tumors.
Carcinogenesis 1986;7(6):943-7.
1985: Sussman I; Prettyman R; O'Brien T G
Phorbol esters and gene expression: the role of rapid changes in K+ transport in the induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate in BALB/c 3T3 cells and a mutant cell line defective in Na+K+Cl- cotransport.
The Journal of cell biology 1985;101(6):2316-23.
1985: Gilmour S K; Avdalovic N; Madara T; O'Brien T G
Induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol 13-acetate in hamster fibroblasts. Relationship between levels of enzyme activity, immunoreactive protein, and RNA during the induction process.
The Journal of biological chemistry 1985;260(30):16439-44.
1985: Sussman I; O'Brien T G
Characterization of a BALB/c 3T3 preadipose cell mutant with altered Na+K+Cl- cotransport activity.
Journal of cellular physiology 1985;124(1):153-9.
1983: Sina J F; Bradley M O; Diamond L; O'Brien T G
Ornithine decarboxylase activity and DNA synthesis in primary and transformed hamster epidermal cells exposed to tumor promoter.
Cancer research 1983;43(9):4108-13.
1982: Sina J F; Bradley M O; O'Brien T G
Neoplastic transformation of Syrian hamster epidermal cells in vitro.
Cancer research 1982;42(10):4116-23.
1982: O'Brien T G; Saladik D
Regulation of hexose transport in BALB/c 3T3 preadipose cells: effects of glucose concentration and 12-O-tetradecanoylphorbol-13-acetate.
Journal of cellular physiology 1982;112(3):376-84.
1982: O'Brien T G; Saladik D; Diamond L
Effects of tumor-promoting phorbol diesters on neoplastic progression of Syrian hamster embryo cells.
Cancer research 1982;42(4):1233-8.
1982: O'Brien T G; Saladik D; Sina J F; Mullin J M
Formation of a glucuronide conjugate of 12-O-tetradecanoylphorbol-13-acetate by LLC-PK1 renal epithelial cells in culture.
Carcinogenesis 1982;3(10):1165-9.
1980: O'Brien T G; Saladik D
Differences in the metabolism of 12-O-[3H]tetradecanoylphorbol-13-acetate and [3H]phorbol-12,13-didecanoate by cells in culture.
Cancer research 1980;40(12):4433-7.
1980: O'Brien T G; Saladik D; Diamond L
Regulation of polyamine biosynthesis in normal and transformed hamster cells in culture.
Biochimica et biophysica acta 1980;632(2):270-83.
1980: O'Brien T G; Saladik D
Inhibition of the adipose conversion of BALB/c 3T3 cells by 12-O-tetradecanoylphorbol-13-acetate: dependence on pH reduction via lactic acid production.
Journal of cellular physiology 1980;104(1):35-40.

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