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Brian O'connor

Research Profile

Disorders

Asthma

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Brian J O'connor; Stephen Kilfeather; David Cheung; Henri Kafé; Mark D Blagden; Noël Schlösser; Jon G Ayres; Hans-Jochen Weber; Renate Engelstätter
Efficacy and safety of ciclesonide in patients with severe asthma: a 12-week, double-blind, randomized, parallel-group study with long-term (1-year) follow-up.
Katharina Mahn; Stuart J Hirst; Sun Ying; Mark Holt; Paul Lavender; Oluwaseun O Ojo; Leonard Siew; David E Simcock; Clare McVicker; Varsha Kanabar; Vladimir A Snetkov; Brian J O'connor; Charlotta Karner; David J Cousins; Patricia Macedo; K Fan Chung; Christopher J Corrigan; Jeremy P T Ward; Tak H Lee
Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma.
David E Simcock; Varsha Kanabar; Graham W Clarke; Katharina Mahn; Charlotta Karner; Brian J O'connor; Tak H Lee; Stuart J Hirst
Induction of angiogenesis by airway smooth muscle from patients with asthma.

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All Publications

2010: Brian J O'connor; Stephen Kilfeather; David Cheung; Henri Kafé; Mark D Blagden; Noël Schlösser; Jon G Ayres; Hans-Jochen Weber; Renate Engelstätter
Efficacy and safety of ciclesonide in patients with severe asthma: a 12-week, double-blind, randomized, parallel-group study with long-term (1-year) follow-up.
Expert opinion on pharmacotherapy 2010;11(17):2791-803.
2009: Katharina Mahn; Stuart J Hirst; Sun Ying; Mark Holt; Paul Lavender; Oluwaseun O Ojo; Leonard Siew; David E Simcock; Clare McVicker; Varsha Kanabar; Vladimir A Snetkov; Brian J O'connor; Charlotta Karner; David J Cousins; Patricia Macedo; K Fan Chung; Christopher J Corrigan; Jeremy P T Ward; Tak H Lee
Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(26):10775-80.
2008: David E Simcock; Varsha Kanabar; Graham W Clarke; Katharina Mahn; Charlotta Karner; Brian J O'connor; Tak H Lee; Stuart J Hirst
Induction of angiogenesis by airway smooth muscle from patients with asthma.
American journal of respiratory and critical care medicine 2008;178(5):460-8.
2008: V Kanabar; Clive P Page; D E Simcock; C Karner; Katharina Mahn; Brian J O'connor; Stuart J Hirst
Heparin and structurally related polymers attenuate eotaxin-1 (CCL11) release from human airway smooth muscle.
British journal of pharmacology 2008;154(4):833-42.
2008: R A Brown; G W Clarke; C L Ledbetter; M J Hurle; J C Denyer; D E Simcock; J E Coote; T J Savage; R D Murdoch; Clive P Page; Domenico Spina; Brian J O'connor
Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(2):311-9.
2007: David E Simcock; Varsha Kanabar; Graham W Clarke; Brian J O'connor; Tak H Lee; Stuart J Hirst
Proangiogenic activity in bronchoalveolar lavage fluid from patients with asthma.
American journal of respiratory and critical care medicine 2007;176(2):146-53.
2007: Brian J O'connor; Claes-Göran AH Löfdahl; Meyer Balter; Andrew Szczeklik; Louis-Philippe Boulet; Charles Cairns
Zileuton added to low-dose inhaled beclomethasone for the treatment of moderate to severe persistent asthma.
Respiratory medicine 2007;101(6):1088-96.
2007: Pooja Takhar; Christopher J Corrigan; Lyn Smurthwaite; Brian J O'connor; Stephen R Durham; Tak H Lee; Hannah J Gould
Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma.
The Journal of allergy and clinical immunology 2007;119(1):213-8.
2007: Neil Jones; Murielle Leport; T Holand; T Vos; M Morgan; M Fink; Marie-Pierre Pruniaux; C Berthelier; Brian J O'connor; Claude P Bertrand; Clive P Page
Phosphodiesterase (PDE) 7 in inflammatory cells from patients with asthma and COPD.
Pulmonary pharmacology & therapeutics 2007;20(1):60-8.
2006: Vivien Chan; Janette K Burgess; Jonathan Ratoff; Brian J O'connor; Anne Greenough; Tak H Lee; Stuart J Hirst
Extracellular matrix regulates enhanced eotaxin expression in asthmatic airway smooth muscle cells.
American journal of respiratory and critical care medicine 2006;174(4):379-85.
2006: Tuck-Kay Loke; Kirsty Mallett; Jonathan Ratoff; Brian J O'connor; Sun Ying; Qiu Meng; Cecilia Soh; Tak H Lee; Christopher J Corrigan
Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients.
The Journal of allergy and clinical immunology 2006;118(2):368-75.
2006: Li-Cher Loh; W H Lo; Varsha Kanabar; Brian J O'connor
Lack of neutrophil degranulation in low-dose endotoxin inhalation based on a novel intracellular assay.
Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand 2006;24(2-3):153-60.
2006: Li-Cher Loh; Beejal Vyas; Varsha Kanabar; D M Kemeny; Brian J O'connor
Inhaled endotoxin in healthy human subjects: a dose-related study on systemic effects and peripheral CD4+ and CD8+ T cells.
Respiratory medicine 2006;100(3):519-28.
2005: Li-Cher Loh; Varsha Kanabar; M D'Amato; Neil C Barnes; Brian J O'connor
Sputum induction in corticosteroid-dependant asthmatics: risks and airway cellular profile.
Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand 2005;23(4):189-96.
2005: Varsha Kanabar; Stuart J Hirst; Brian J O'connor; Clive P Page
Some structural determinants of the antiproliferative effect of heparin-like molecules on human airway smooth muscle.
British journal of pharmacology 2005;146(3):370-7.
2004: Sun Ying; Brian J O'connor; Qiu Meng; Natalie Woodman; Steven Greenaway; Helen Wong; Kirsty Mallett; Tak H Lee; Christopher J Corrigan
Expression of prostaglandin E(2) receptor subtypes on cells in sputum from patients with asthma and controls: effect of allergen inhalational challenge.
The Journal of allergy and clinical immunology 2004;114(6):1309-16.
2004: Brian J O'connor
The ideal inhaler: design and characteristics to improve outcomes.
Respiratory medicine 2004;98 Suppl A():S10-6.
2002: Donna Donigi Gale; Linda Landells; Domenico Spina; Alan J Miller; Kate Smith; Terry Nichols; Yakov Rotshteyn; Alfred Tonelli; Peter Lacouture; Ronald M Burch; Clive P Page; Brian J O'connor
Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers.
British journal of clinical pharmacology 2002;54(5):478-84.
2002: Robert I Ketchell; Marianne W Jensen; Philip Lumley; Andrew M Wright; Mark I Allenby; Brian J O'connor
Rapid effect of inhaled fluticasone propionate on airway responsiveness to adenosine 5'-monophosphate in mild asthma.
The Journal of allergy and clinical immunology 2002;110(4):603-6.
2002: Robert I Ketchell; M D'Amato; Marianne W Jensen; Brian J O'connor
Contrasting effects of allergen challenge on airway responsiveness to cysteinyl leukotriene D(4) and methacholine in mild asthma.
Thorax 2002;57(7):575-80.
2002: Robert I Ketchell; Marianne W Jensen; Domenico Spina; Brian J O'connor
Dose-related effects of formoterol on airway responsiveness to adenosine 5'-monophosphate and histamine.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(4):611-6.
2001: Linda Landells; C M Szilagy; Neil Jones; Katherine H Banner; J M Allen; A Doherty; Brian J O'connor; Domenico Spina; Clive P Page
Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects.
British journal of pharmacology 2001;133(5):722-9.
2000: Shannon A Bryan; Brian J O'connor; S Matti; MJ Leckie; Varsha Kanabar; J Khan; Steve Warrington; L Renzetti; A Rames; J A Bock; Malcolm Boyce; Trevor T Hansel; Stephen T Holgate; Peter J Barnes
Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response.
Lancet 2000;356(9248):2149-53.
2000: MJ Leckie; A ten Brinke; J Khan; Z Diamant; Brian J O'connor; C M Walls; A K Mathur; H C Cowley; K Fan Chung; R Djukanovic; Trevor T Hansel; Stephen T Holgate; P J Sterk; Peter J Barnes
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.
Lancet 2000;356(9248):2144-8.
2000: C A Osborne; Brian J O'connor; A Lewis; Varsha Kanabar; W N Gardner
Hyperventilation and asymptomatic chronic asthma.
Thorax 2000;55(12):1016-22.
2000: Linda Landells; Marianne W Jensen; L M Orr; Domenico Spina; Brian J O'connor; Clive P Page
The role of adenosine receptors in the action of theophylline on human peripheral blood mononuclear cells from healthy and asthmatic subjects.
British journal of pharmacology 2000;129(6):1140-4.
2000: Linda Landells; Domenico Spina; J E Souness; Brian J O'connor; Clive P Page
A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects.
Pulmonary pharmacology & therapeutics 2000;13(5):231-9.
2000: DA Taylor; J G Harris; Brian J O'connor
Comparison of incremental and bolus dose inhaled allergen challenge in asthmatic patients.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(1):56-63.
1999: D M Kemeny; Beejal Vyas; M Vukmanovic-Stejic; M J Thomas; A Noble; L C Loh; Brian J O'connor
CD8(+) T cell subsets and chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 1999;160(5 Pt 2):S33-7.
1999: D J Evans; Mark A Lindsay; BL Webb; Hannu Kankaanranta; Mark A Giembycz; Brian J O'connor; Peter J Barnes
Expression and activation of protein kinase C-zeta in eosinophils after allergen challenge.
The American journal of physiology 1999;277(2 Pt 1):L233-9.
1999: DA Taylor; Marianne W Jensen; Varsha Kanabar; Renate Engelstätter; VW Steinijans; Peter J Barnes; Brian J O'connor
A dose-dependent effect of the novel inhaled corticosteroid ciclesonide on airway responsiveness to adenosine-5'-monophosphate in asthmatic patients.
American journal of respiratory and critical care medicine 1999;160(1):237-43.
1999: Brian J O'connor; SD Crowther; JF Costello; John Morley
Selective airway responsiveness in asthma.
Trends in pharmacological sciences 1999;20(1):9-11.
1999: Sam Lim; Anon Jatakanon; M John; T Gilbey; Brian J O'connor; K Fan Chung; Peter J Barnes
Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma.
American journal of respiratory and critical care medicine 1999;159(1):22-30.
1998: DA Taylor; J L McGrath; Brian J O'connor; Peter J Barnes
Allergen-induced early and late asthmatic responses are not affected by inhibition of endogenous nitric oxide.
American journal of respiratory and critical care medicine 1998;158(1):99-106.
1998: DA Taylor; J L McGrath; L M Orr; Peter J Barnes; Brian J O'connor
Effect of endogenous nitric oxide inhibition on airway responsiveness to histamine and adenosine-5'-monophosphate in asthma.
Thorax 1998;53(6):483-9.
1998: Paul M Seldon; D A Stevens; Ian M Adcock; Brian J O'connor; Peter J Barnes; Mark A Giembycz
Albuterol does not antagonize the inhibitory effect of dexamethasone on monocyte cytokine release.
American journal of respiratory and critical care medicine 1998;157(3 Pt 1):803-9.
1997: DA Taylor; Marianne W Jensen; S L Aikman; J G Harris; Peter J Barnes; Brian J O'connor
Comparison of salmeterol and albuterol-induced bronchoprotection against adenosine monophosphate and histamine in mild asthma.
American journal of respiratory and critical care medicine 1997;156(6):1731-7.
1997: D J Evans; D A Taylor; O Zetterstrom; K Fan Chung; Brian J O'connor; Peter J Barnes
A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma.
The New England journal of medicine 1997;337(20):1412-8.
1997: VM Keatings; Brian J O'connor; L G Wright; David P Huston; Christopher J Corrigan; Peter J Barnes
Late response to allergen is associated with increased concentrations of tumor necrosis factor-alpha and IL-5 in induced sputum.
The Journal of allergy and clinical immunology 1997;99(5):693-8.
1997: VM Keatings; D J Evans; Brian J O'connor; Peter J Barnes
Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid.
Thorax 1997;52(4):372-4.
1996: D J Evans; L J Coulby; Brian J O'connor
Effect of allergen challenge on airway responsiveness to histamine and sodium metabisulphite in mild asthma.
Thorax 1996;51(12):1185-91.
1996: D J Evans; Peter J Barnes; SM Spaethe; E L van Alstyne; M I Mitchell; Brian J O'connor
Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma.
Thorax 1996;51(12):1178-84.
1996: Sergei A Kharitonov; K Fan Chung; D Evans; Brian J O'connor; Peter J Barnes
Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract.
American journal of respiratory and critical care medicine 1996;153(6 Pt 1):1773-80.
1996: C M Gelder; Peter J Barnes; Brian J O'connor; K Fan Chung; Ian M Adcock
Cytokine mRNA profiles of normal and asthmatic peripheral blood cells and endobronchial biopsies.
Biochemical Society transactions 1996;24(2):315S.
1996: D J Evans; Mark A Lindsay; Brian J O'connor; Peter J Barnes
Priming of circulating human eosinophils following late response to allergen challenge.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(4):703-8.
1995: Deborah H Yates; Brian J O'connor; G Yilmaz; S Aikman; M Worsdell; Peter J Barnes; K Fan Chung
Effect of acute and chronic inhaled furosemide on bronchial hyperresponsiveness in mild asthma.
American journal of respiratory and critical care medicine 1995;152(6 Pt 1):2173-5.
1995: Sergei A Kharitonov; Brian J O'connor; D J Evans; Peter J Barnes
Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide.
American journal of respiratory and critical care medicine 1995;151(6):1894-9.
1995: Sergei A Kharitonov; A U Wells; Brian J O'connor; Peter J Cole; David Hansell; R B Logan-Sinclair; Peter J Barnes
Elevated levels of exhaled nitric oxide in bronchiectasis.
American journal of respiratory and critical care medicine 1995;151(6):1889-93.
1995: Peter J Barnes; Brian J O'connor
Use of a fixed combination beta 2-agonist and steroid dry powder inhaler in asthma.
American journal of respiratory and critical care medicine 1995;151(4):1053-7.
1994: Brian J O'connor; C T Yeo; Y M Chen-Worsdell; Peter J Barnes; K Fan Chung
Effect of acetazolamide and amiloride against sodium metabisulphite-induced bronchoconstriction in mild asthma.
Thorax 1994;49(11):1096-8.
1994: Brian J O'connor; R W Fuller; Peter J Barnes
Nonbronchodilator effects of inhaled beta 2 agonists. Greater protection against adenosine monophosphate- than methacholine-induced bronchoconstriction in asthma.
American journal of respiratory and critical care medicine 1994;150(2):381-7.
1994: Brian J O'connor; S Uden; T J Carty; James D Eskra; Peter J Barnes; K Fan Chung
Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans.
American journal of respiratory and critical care medicine 1994;150(1):35-40.
1994: Brian J O'connor; Peter J Barnes; K Fan Chung
Inhibition of sodium metabisulphite induced bronchoconstriction by frusemide in asthma: role of cyclooxygenase products.
Thorax 1994;49(4):307-11.
1993: Brian J O'connor; J M Lecomte; Peter J Barnes
Effect of an inhaled histamine H3-receptor agonist on airway responses to sodium metabisulphite in asthma.
British journal of clinical pharmacology 1993;35(1):55-7.
1992: C T Yeo; Brian J O'connor; M Chen-Worsdell; Peter J Barnes; K F Chung
Protective effect of loop diuretics, piretanide and frusemide, against sodium metabisulphite-induced bronchoconstriction in asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1992;5(10):1184-8.
1992: Brian J O'connor; S L Aikman; Peter J Barnes
Tolerance to the nonbronchodilator effects of inhaled beta 2-agonists in asthma.
The New England journal of medicine 1992;327(17):1204-8.
1992: Brian J O'connor; S M Ridge; Peter J Barnes; R W Fuller
Greater effect of inhaled budesonide on adenosine 5'-monophosphate-induced than on sodium-metabisulfite-induced bronchoconstriction in asthma.
The American review of respiratory disease 1992;146(3):560-4.
1992: G M Nichol; Brian J O'connor; J M Lecomte; K Fan Chung; Peter J Barnes
Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects.
European journal of clinical pharmacology 1992;42(5):491-4.
1991: Brian J O'connor; K Fan Chung; Y M Chen-Worsdell; R W Fuller; Peter J Barnes
Effect of inhaled furosemide and bumetanide on adenosine 5'-monophosphate- and sodium metabisulfite-induced bronchoconstriction in asthmatic subjects.
The American review of respiratory disease 1991;143(6):1329-33.