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Michael O'Connor

Research Profile

Chemicals & Drugs

Living Beings

Physiology

Anatomy

Cells, Cultured

Disorders

Myocardial Reperfusion Injury

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Publications

TOP 3
Ranjit S Chima; Giuseppe Maltese; Timberly Lamontagne; Giovanna Piraino; Alvin Denenberg; Michael O'Connor; Basilia Zingarelli
C-peptide ameliorates kidney injury following hemorrhagic shock.
Basilia Zingarelli; Giovanna Piraino; Paul W Hake; Michael O'Connor; Alvin Denenberg; Hongkuan Fan; James A Cook
Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis.
Ranjit S Chima; Paul W Hake; Giovanna Piraino; Prajakta Mangeshkar; Michael O'Connor; Basilia Zingarelli
Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shock.

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All Publications

2011: Ranjit S Chima; Giuseppe Maltese; Timberly Lamontagne; Giovanna Piraino; Alvin Denenberg; Michael O'Connor; Basilia Zingarelli
C-peptide ameliorates kidney injury following hemorrhagic shock.
Shock (Augusta, Ga.) 2011;35(5):524-9.
2010: Basilia Zingarelli; Giovanna Piraino; Paul W Hake; Michael O'Connor; Alvin Denenberg; Hongkuan Fan; James A Cook
Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis.
The American journal of pathology 2010;177(4):1834-47.
2010: Ranjit S Chima; Paul W Hake; Giovanna Piraino; Prajakta Mangeshkar; Michael O'Connor; Basilia Zingarelli
Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shock.
International journal of clinical and experimental medicine 2010;3(1):1-9.
2010: Basilia Zingarelli; Ranjit Chima; Michael O'Connor; Giovanna Piraino; Alvin Denenberg; Paul W Hake
Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock.
American journal of physiology. Gastrointestinal and liver physiology 2010;298(1):G133-41.
2009: Basilia Zingarelli; Paul W Hake; Michael O'Connor; Timothy J Burroughs; Hector R Wong; Joseph S Solomkin; Alex B Lentsch
Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma.
Critical care medicine 2009;37(6):1978-87.
2008: Patricia A Abboud; Paul W Hake; Timothy J Burroughs; Kelli Odoms; Michael O'Connor; Prajakta Mangeshkar; Hector R Wong; Basilia Zingarelli
Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis.
European journal of pharmacology 2008;579(1-3):411-7.
2007: Jennifer Kaplan; James A Cook; Michael O'Connor; Basilia Zingarelli
Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells.
Shock (Augusta, Ga.) 2007;28(6):722-726.
2007: Basilia Zingarelli; Paul W Hake; Prajakta Mangeshkar; Michael O'Connor; Timothy J Burroughs; Giovanna Piraino; Alvin Denenberg; Hector R Wong
Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt.
Shock (Augusta, Ga.) 2007;28(5):554-63.
2007: Michael G Vish; Prajakta Mangeshkar; Giovanna Piraino; Alvin Denenberg; Paul W Hake; Michael O'Connor; Basilia Zingarelli
Proinsulin c-peptide exerts beneficial effects in endotoxic shock in mice.
Critical care medicine 2007;35(5):1348-55.
2007: Pierre-Yves Berclaz; Brenna Carey; Marie-Dominique Fillipi; Kara Wernke-Dollries; Nick Geraci; Stephanie Cush; Terry Richardson; Joseph A Kitzmiller; Michael O'Connor; Christina Hermoyian; Thomas R Korfhagen; Jeffrey A Whitsett; Bruce C Trapnell
GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS.
American journal of respiratory cell and molecular biology 2007;36(1):114-21.
2006: Giovanna Piraino; James A Cook; Michael O'Connor; Paul W Hake; Timothy J Burroughs; Diana Teti; Basilia Zingarelli
Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages.
Shock (Augusta, Ga.) 2006;26(2):146-53.
2005: Jennifer M Kaplan; James A Cook; Paul W Hake; Michael O'Connor; Timothy J Burroughs; Basilia Zingarelli
15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock.
Shock (Augusta, Ga.) 2005;24(1):59-65.
2005: Jennifer Kaplan; Michael O'Connor; Paul W Hake; Basilia Zingarelli
Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration.
Shock (Augusta, Ga.) 2005;23(3):233-8.
2004: Basilia Zingarelli; Paul W Hake; Timothy J Burroughs; Giovanna Piraino; Michael O'Connor; Alvin Denenberg
Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis.
Immunology 2004;113(4):509-17.
2004: Basilia Zingarelli; Paul W Hake; Michael O'Connor; Alvin Denenberg; Hector R Wong; Sue Kong; Bruce Aronow
Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.
American journal of physiology. Heart and circulatory physiology 2004;286(4):H1408-15.
2003: Basilia Zingarelli; Maeve Sheehan; Paul W Hake; Michael O'Connor; Alvin Denenberg; James A Cook
Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6827-37.
2003: Basilia Zingarelli; Michael O'Connor; Paul W Hake
Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis.
European journal of pharmacology 2003;469(1-3):183-94.
2003: Basilia Zingarelli; Paul W Hake; Michael O'Connor; Alvin Denenberg; Sue Kong; Bruce Aronow
Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury.
Molecular medicine (Cambridge, Mass.) 2003;9(5-8):143-53.
2003: Teresa L Andreone; Michael O'Connor; Alvin Denenberg; Paul W Hake; Basilia Zingarelli
Poly(ADP-ribose) polymerase-1 regulates activation of activator protein-1 in murine fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):2113-20.
2002: Maeve Sheehan; Hector R Wong; Paul W Hake; Vivek Malhotra; Michael O'Connor; Basilia Zingarelli
Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents.
Molecular pharmacology 2002;61(5):953-63.
2002: Basilia Zingarelli; Paul W Hake; Zequan Yang; Michael O'Connor; Alvin Denenberg; Hector R Wong
Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappaB and AP-1 activation and enhances myocardial damage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(3):327-42.
1999: L Viráģ; Gwen S Scott; P Antal-Szalmás; Michael O'Connor; H Ohshima; Csaba Szabó
Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity.
Molecular pharmacology 1999;56(4):824-33.
1998: E Gilad; Hector R Wong; Basilia Zingarelli; Laszlo Virag; Michael O'Connor; Andrew L Salzman; Csaba Szabó
Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFkappaB activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(9):685-93.
1998: S Cuzzocrea; Basilia Zingarelli; Michael O'Connor; Andrew L Salzman; Csaba Szabó
Effect of L-buthionine-(S,R)-sulphoximine, an inhibitor of gamma-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock-induced vascular failure.
British journal of pharmacology 1998;123(3):525-37.
1997: Michael O'Connor; Andrew L Salzman; Csaba Szabó
Role of peroxynitrite in the protein oxidation and apoptotic DNA fragmentation in vascular smooth muscle cells stimulated with bacterial lipopolysaccharide and interferon-gamma.
Shock (Augusta, Ga.) 1997;8(6):439-43.
1997: Csaba Szabó; C Saunders; Michael O'Connor; Andrew L Salzman
Peroxynitrite causes energy depletion and increases permeability via activation of poly (ADP-ribose) synthetase in pulmonary epithelial cells.
American journal of respiratory cell and molecular biology 1997;16(2):105-9.
1997: Basilia Zingarelli; G J Southan; E Gilad; Michael O'Connor; Andrew L Salzman; Csaba Szabó
The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity.
British journal of pharmacology 1997;120(3):357-66.
1996: G J Southan; Basilia Zingarelli; Michael O'Connor; Andrew L Salzman; Csaba Szabó
Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform.
British journal of pharmacology 1996;117(4):619-32.