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Patrick O'Connor

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Genes, p53

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TOP 3
Patrizia Russo; Davide Malacarne; Carla Falugi; Sonya Trombino; Patrick M O'Connor
RPR-115135, a farnesyltransferase inhibitor, increases 5-FU- cytotoxicity in ten human colon cancer cell lines: role of p53.
Patrizia Russo; Cristina Ottoboni; Davide Malacarne; Alessandra Crippa; Jean-Francois Riou; Patrick M O'Connor
Nonpeptidomimetic farnesyltransferase inhibitor RPR-115135 increases cytotoxicity of 5-fluorouracil: role of p53.
J Jackman; Patrick M O'Connor
Methods for synchronizing cells at specific stages of the cell cycle.

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2002: Patrizia Russo; Davide Malacarne; Carla Falugi; Sonya Trombino; Patrick M O'Connor
RPR-115135, a farnesyltransferase inhibitor, increases 5-FU- cytotoxicity in ten human colon cancer cell lines: role of p53.
International journal of cancer. Journal international du cancer 2002;100(3):266-75.
2002: Patrizia Russo; Cristina Ottoboni; Davide Malacarne; Alessandra Crippa; Jean-Francois Riou; Patrick M O'Connor
Nonpeptidomimetic farnesyltransferase inhibitor RPR-115135 increases cytotoxicity of 5-fluorouracil: role of p53.
The Journal of pharmacology and experimental therapeutics 2002;300(1):220-6.
2001: J Jackman; Patrick M O'Connor
Methods for synchronizing cells at specific stages of the cell cycle.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Chapter 8():Unit 8.3.
2001: Patrizia Russo; Cristina Ottoboni; Alessandra Crippa; Jean-Francois Riou; Patrick M O'Connor
RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G0/G1 arrest only in serum starved cells.
International journal of oncology 2001;18(4):855-62.
2000: P R Graves; L Yu; Julie K Schwarz; J Gales; Edward A Sausville; Patrick M O'Connor; Helen Piwnica-Worms
The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.
The Journal of biological chemistry 2000;275(8):5600-5.
1999: Michihiro Mutoh; Feng-Di T Lung; Ya-Qiu Long; Peter P Roller; R S Sikorski; Patrick M O'Connor
A p21(Waf1/Cip1)carboxyl-terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells.
Cancer research 1999;59(14):3480-8.
1999: Xin Wei Wang; Qimin Zhan; JD Coursen; M A Khan; H Udo Kontny; Linda Yu; M Christine Hollander; Patrick M O'Connor; Albert J Fornace; Curtis C Harris
GADD45 induction of a G2/M cell cycle checkpoint.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3706-11.
1999: Patrizia Russo; Cristina Ottoboni; Carla Falugi; William C Reinhold; Jean-Francois Riou; Stefano Parodi; Patrick M O'Connor
Cellular effects of a new farnesyltransferase inhibitor, RPR-115135, in a human isogenic colon cancer cell line model system HCT-116.
Annals of the New York Academy of Sciences 1999;886():252-6.
1998: Linda Yu; Linda Orlandi; P Wang; M S Orr; Adrian M Senderowicz; Edward A Sausville; R Silvestrini; N Watanabe; Helen Piwnica-Worms; Patrick M O'Connor
UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.
The Journal of biological chemistry 1998;273(50):33455-64.
1998: S Fan; Barry Cherney; William C Reinhold; K Rucker; Patrick M O'Connor
Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(4):1047-54.
1998: Leming Shi; Y Fan; Timothy G Myers; Patrick M O'Connor; KD Paull; SH Friend; John N Weinstein
Mining the NCI anticancer drug discovery databases: genetic function approximation for the QSAR study of anticancer ellipticine analogues.
Journal of chemical information and computer sciences 1998;38(2):189-99.
1998: M S Orr; William C Reinhold; Linda Yu; N Schreiber-Agus; Patrick M O'Connor
An important role for the retinoblastoma protein in staurosporine-induced G1 arrest in murine embryonic fibroblasts.
The Journal of biological chemistry 1998;273(7):3803-7.
1998: Leming Shi; Timothy G Myers; Y Fan; Patrick M O'Connor; KD Paull; SH Friend; John N Weinstein
Mining the National Cancer Institute Anticancer Drug Discovery Database: cluster analysis of ellipticine analogs with p53-inverse and central nervous system-selective patterns of activity.
Molecular pharmacology 1998;53(2):241-51.
1997: Patrick M O'Connor; J Jackman; I Bae; Timothy G Myers; S Fan; Michihiro Mutoh; Dominic A Scudiero; Anne Monks; Edward A Sausville; John N Weinstein; SH Friend; Albert J Fornace; Kurt W Kohn
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.
Cancer research 1997;57(19):4285-300.
1997: Rong-Guang Shao; Chun-Xia Cao; T Shimizu; Patrick M O'Connor; Kurt W Kohn; Yves Pommier
Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.
Cancer research 1997;57(18):4029-35.
1997: M Gupta; S Fan; Qimin Zhan; Kurt W Kohn; Patrick M O'Connor; Yves Pommier
Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(9):1653-60.
1997: S Fan; J K Chang; ML Smith; D Duba; Albert J Fornace; Patrick M O'Connor
Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard.
Oncogene 1997;14(18):2127-36.
1997: Patrick M O'Connor
Mammalian G1 and G2 phase checkpoints.
Cancer surveys 1997;29():151-82.
1996: Qimin Zhan; I Alamo; K Yu; Lawrence Boise; Barry Cherney; Giovanna Tosato; Patrick M O'Connor; Albert J Fornace
The apoptosis-associated gamma-ray response of BCL-X(L) depends on normal p53 function.
Oncogene 1996;13(10):2287-93.
1996: ML Smith; H Udo Kontny; Qimin Zhan; A Sreenath; Patrick M O'Connor; Albert J Fornace
Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to u.v.-irradiation or cisplatin.
Oncogene 1996;13(10):2255-63.
1996: Qimin Zhan; S Fan; ML Smith; I Bae; K Yu; I Alamo; Patrick M O'Connor; Albert J Fornace
Abrogation of p53 function affects gadd gene responses to DNA base-damaging agents and starvation.
DNA and cell biology 1996;15(10):805-15.
1996: F Goldwasser; T Shimizu; J Jackman; Yuko Hoki; Patrick M O'Connor; Kurt W Kohn; Yves Pommier
Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.
Cancer research 1996;56(19):4430-7.
1996: Q Wang; S Fan; A Eastman; P J Worland; Edward A Sausville; Patrick M O'Connor
UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
Journal of the National Cancer Institute 1996;88(14):956-65.
1996: R L Morton; H David; Patrick M O'Connor; Michael Bustin
Chromosomal proteins HMG-14 and HMG-17 are synthesized throughout the S-phase in Burkitt's lymphoma.
Biochemical and biophysical research communications 1996;222(2):368-73.
1996: I Bae; ML Smith; MS Sheikh; Qimin Zhan; Dominic A Scudiero; S H Friend; Patrick M O'Connor; Albert J Fornace
An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines.
Cancer research 1996;56(4):840-7.
1996: I T Chen; M Akamatsu; ML Smith; Feng-Di T Lung; D Duba; Peter P Roller; Albert J Fornace; Patrick M O'Connor
Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction.
Oncogene 1996;12(3):595-607.
1996: Patrick M O'Connor; S Fan
DNA damage checkpoints: implications for cancer therapy.
Progress in cell cycle research 1996;2():165-73.
1995: Tommaso Russo; Nicola Zambrano; Franca Esposito; Rosario Ammendola; Filiberto Cimino; Michele Fiscella; J Jackman; Patrick M O'Connor; C W Anderson; Ettore Appella
A p53-independent pathway for activation of WAF1/CIP1 expression following oxidative stress.
The Journal of biological chemistry 1995;270(49):29386-91.
1995: I T Chen; ML Smith; Patrick M O'Connor; Albert J Fornace
Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA.
Oncogene 1995;11(10):1931-7.
1995: R Hamanaka; M R Smith; Patrick M O'Connor; S Maloid; K Mihalic; Jerry L Spivak; Dan Longo; Douglass K Ferris
Polo-like kinase is a cell cycle-regulated kinase activated during mitosis.
The Journal of biological chemistry 1995;270(36):21086-91.
1995: I Bae; S Fan; Kishor Bhatia; Kurt W Kohn; Albert J Fornace; Patrick M O'Connor
Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following gamma-irradiation of human lymphoma cells.
Cancer research 1995;55(11):2387-93.
1995: S Fan; ML Smith; Dennis Rivet; D Duba; Qimin Zhan; Kurt W Kohn; Albert J Fornace; Patrick M O'Connor
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
Cancer research 1995;55(8):1649-54.
1995: Kishor Bhatia; S Fan; G Spangler; M Weintraub; Patrick M O'Connor; J G Judde; Ian Magrath
A mutant p21 cyclin-dependent kinase inhibitor isolated from a Burkitt's lymphoma.
Cancer research 1995;55(7):1431-5.
1995: ML Smith; I T Chen; Qimin Zhan; Patrick M O'Connor; Albert J Fornace
Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.
Oncogene 1995;10(6):1053-9.
1995: T Shimizu; Patrick M O'Connor; Kurt W Kohn; Yves Pommier
Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage.
Cancer research 1995;55(2):228-31.
1994: Qimin Zhan; S Fan; I Bae; Christel Guillouf; Dan A Liebermann; Patrick M O'Connor; Albert J Fornace
Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.
Oncogene 1994;9(12):3743-51.
1994: ML Smith; I T Chen; Qimin Zhan; I Bae; C Y Chen; Tona M Gilmer; Michael B Kastan; Patrick M O'Connor; Albert J Fornace
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
Science (New York, N.Y.) 1994;266(5189):1376-80.
1994: S Fan; Wafik S El-Deiry; I Bae; J Freeman; D Jondle; Kishor Bhatia; Albert J Fornace; Ian Magrath; Kurt W Kohn; Patrick M O'Connor
p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.
Cancer research 1994;54(22):5824-30.
1994: D Lin; Michele Fiscella; Patrick M O'Connor; J Jackman; M Chen; L L Luo; A Sala; Salvatore Travali; Ettore Appella; WE Mercer
Constitutive expression of B-myb can bypass p53-induced Waf1/Cip1-mediated G1 arrest.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):10079-83.
1994: Patrick M O'Connor; Douglass K Ferris; I Hoffmann; J Jackman; G Draetta; Kurt W Kohn
Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9480-4.
1994: K Wassermann; Patrick M O'Connor; J Jackman; A May; V A Bohr
Transcription-independent repair of nitrogen mustard-induced N-alkylpurines in the c-myc gene in Burkitt's lymphoma CA46 cells.
Carcinogenesis 1994;15(9):1779-83.
1994: K W Kohn; J Jackman; Patrick M O'Connor
Cell cycle control and cancer chemotherapy.
Journal of cellular biochemistry 1994;54(4):440-52.
1994: Johann Hofmann; Patrick M O'Connor; J Jackman; C Schubert; F Ueberall; K W Kohn; Hans H Grunicke
The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents.
Biochemical and biophysical research communications 1994;199(2):937-43.
1994: Wafik S El-Deiry; J W Harper; Patrick M O'Connor; Victor E Velculescu; Shilpy Sharma; J Jackman; J A Pietenpol; M Burrell; David E Hill; Y Wang
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
Cancer research 1994;54(5):1169-74.
1994: Kurt W Kohn; Ann H Orr; Patrick M O'Connor; L J Guziec; F S Guziec
Synthesis and DNA-sequence selectivity of a series of mono- and difunctional 9-aminoacridine nitrogen mustards.
Journal of medicinal chemistry 1994;37(1):67-72.
1993: Patrick M O'Connor; J Jackman; D Jondle; Kishor Bhatia; Ian Magrath; Kurt W Kohn
Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.
Cancer research 1993;53(20):4776-80.
1993: Patrick M O'Connor; Douglass K Ferris; M Pagano; G Draetta; J Pines; Tony Hunter; Dan Longo; Kurt W Kohn
G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.
The Journal of biological chemistry 1993;268(11):8298-308.
1992: Patrick M O'Connor; Douglass K Ferris; G A White; J Pines; Tony Hunter; Dan Longo; Kurt W Kohn
Relationships between cdc2 kinase, DNA cross-linking, and cell cycle perturbations induced by nitrogen mustard.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(1):43-52.
1992: R Bertrand; Patrick M O'Connor; D Kerrigan; Yves Pommier
Sequential administration of camptothecin and etoposide circumvents the antagonistic cytotoxicity of simultaneous drug administration in slowly growing human colon carcinoma HT-29 cells.
European journal of cancer (Oxford, England : 1990) 1992;28A(4-5):743-8.
1991: Patrick M O'Connor; K Wassermann; M Sarang; Ian Magrath; Vilhelm A Bohr; Kurt W Kohn
Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard.
Cancer research 1991;51(24):6550-7.
1991: Patrick M O'Connor; W Nieves-Neira; D Kerrigan; R Bertrand; Jonathan Goldman; Kurt W Kohn; Yves Pommier
S-phase population analysis does not correlate with the cytotoxicity of camptothecin and 10,11-methylenedioxycamptothecin in human colon carcinoma HT-29 cells.
Cancer communications 1991;3(8):233-40.
1990: Patrick M O'Connor; Kurt W Kohn
Comparative pharmacokinetics of DNA lesion formation and removal following treatment of L1210 cells with nitrogen mustards.
Cancer communications 1990;2(12):387-94.
1990: Patrick M O'Connor; D Kerrigan; R Bertrand; Kurt W Kohn; Yves Pommier
10,11-Methylenedioxycamptothecin, a topoisomerase I inhibitor of increased potency: DNA damage and correlation to cytotoxicity in human colon carcinoma (HT-29) cells.
Cancer communications 1990;2(12):395-400.
1989: Patrick M O'Connor; B W Fox
Isolation and characterization of proteins cross-linked to DNA by the antitumor agent methylene dimethanesulfonate and its hydrolytic product formaldehyde.
The Journal of biological chemistry 1989;264(11):6391-7.