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Sarah O'Connor

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TOP 3
Weslee S Glenn; Weerawat Runguphan; Sarah E O'Connor
Recent progress in the metabolic engineering of alkaloids in plant systems.
Weerawat Runguphan; Weslee S Glenn; Sarah E O'Connor
Redesign of a dioxygenase in morphine biosynthesis.
David K Liscombe; Sarah E O'Connor
A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus.

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All Publications

2013: Weslee S Glenn; Weerawat Runguphan; Sarah E O'Connor
Recent progress in the metabolic engineering of alkaloids in plant systems.
Current opinion in biotechnology 2013;24(2):354-65.
2012: Weerawat Runguphan; Weslee S Glenn; Sarah E O'Connor
Redesign of a dioxygenase in morphine biosynthesis.
Chemistry & biology 2012;19(6):674-8.
2011: David K Liscombe; Sarah E O'Connor
A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus.
Phytochemistry 2011;72(16):1969-77.
2011: Lesley-Ann Giddings; David K Liscombe; John P Hamilton; Kevin L Childs; Dean DellaPenna; C Robin Buell; Sarah E O'Connor
A stereoselective hydroxylation step of alkaloid biosynthesis by a unique cytochrome P450 in Catharanthus roseus.
The Journal of biological chemistry 2011;286(19):16751-7.
2010: Weerawat Runguphan; Xudong Qu; Sarah E O'Connor
Integrating carbon-halogen bond formation into medicinal plant metabolism.
Nature 2010;468(7322):461-4.
2010: David K Liscombe; Aimee R Usera; Sarah E O'Connor
Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):18793-8.
2010: Johnathan Z Cheng; Christine M Coyle; Daniel G Panaccione; Sarah E O'Connor
Controlling a structural branch point in ergot alkaloid biosynthesis.
Journal of the American Chemical Society 2010;132(37):12835-7.
2010: Johnathan Z Cheng; Christine M Coyle; Daniel G Panaccione; Sarah E O'Connor
A role for Old Yellow Enzyme in ergot alkaloid biosynthesis.
Journal of the American Chemical Society 2010;132(6):1776-7.
2009: Hyang-Yeol Lee; Nancy Yerkes; Sarah E O'Connor
Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis.
Chemistry & biology 2009;16(12):1225-9.
2009: Peter Bernhardt; Nancy Yerkes; Sarah E O'Connor
Bypassing stereoselectivity in the early steps of alkaloid biosynthesis.
Organic & biomolecular chemistry 2009;7(20):4166-8.
2009: Aimee R Usera; Sarah E O'Connor
Mechanistic advances in plant natural product enzymes.
Current opinion in chemical biology 2009;13(4):492-8.
2009: Weerawat Runguphan; Justin J Maresh; Sarah E O'Connor
Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):13673-8.
2009: effendi leonard; Weerawat Runguphan; Sarah E O'Connor; Kristala Jones Prather
Opportunities in metabolic engineering to facilitate scalable alkaloid production.
Nature chemical biology 2009;5(5):292-300.
2009: Weerawat Runguphan; Sarah E O'Connor
Metabolic reprogramming of periwinkle plant culture.
Nature chemical biology 2009;5(3):151-3.
2009: Peter Bernhardt; Sarah E O'Connor
Opportunities for enzyme engineering in natural product biosynthesis.
Current opinion in chemical biology 2009;13(1):35-42.
2008: Nancy Yerkes; Jia Xin Wu; Elizabeth McCoy; M Carmen Galan; Shi Chen; Sarah E O'Connor
Substrate specificity and diastereoselectivity of strictosidine glucosidase, a key enzyme in monoterpene indole alkaloid biosynthesis.
Bioorganic & medicinal chemistry letters 2008;18(10):3095-8.
2008: Justin J Maresh; Lesley-Ann Giddings; Anne Friedrich; Elke A Loris; Santosh Panjikar; Bernhardt L Trout; Joachim Stöckigt; Baron Peters; Sarah E O'Connor
Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme.
Journal of the American Chemical Society 2008;130(2):710-23.
2008: Elizabeth McCoy; Sarah E O'Connor
Natural products from plant cell cultures.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 2008;65():329, 331-70.
2007: M Carmen Galan; Elizabeth McCoy; Sarah E O'Connor
Chemoselective derivatization of alkaloids in periwinkle.
Chemical communications (Cambridge, England) 2007;(31):3249-51.
2007: Peter Bernhardt; Elizabeth McCoy; Sarah E O'Connor
Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle.
Chemistry & biology 2007;14(8):888-97.
2006: Elizabeth McCoy; Sarah E O'Connor
Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus.
Journal of the American Chemical Society 2006;128(44):14276-7.
2006: Shi Chen; M Carmen Galan; Carla Coltharp; Sarah E O'Connor
Redesign of a central enzyme in alkaloid biosynthesis.
Chemistry & biology 2006;13(11):1137-41.
2006: Sarah E O'Connor
Cyclization of natural products.
Nature chemical biology 2006;2(10):511-2.
2006: Sarah E O'Connor; Justin J Maresh
Chemistry and biology of monoterpene indole alkaloid biosynthesis.
Natural product reports 2006;23(4):532-47.
2006: Elizabeth McCoy; M Carmen Galan; Sarah E O'Connor
Substrate specificity of strictosidine synthase.
Bioorganic & medicinal chemistry letters 2006;16(9):2475-8.
2005: Frédéric H Vaillancourt; Ellen Yeh; David A Vosburg; Sarah E O'Connor; Christopher T Walsh
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis.
Nature 2005;436(7054):1191-4.
2004: Leslie M Hicks; Sarah E O'Connor; Matthew T Mazur; Christopher T Walsh; Neil L Kelleher
Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis.
Chemistry & biology 2004;11(3):327-35.
2004: Sarah E O'Connor
Aureolic acids: similar antibiotics with different biosynthetic gene clusters.
Chemistry & biology 2004;11(1):8-10.
2004: Robin Couch; Sarah E O'Connor; Heather Couch; Christopher T Walsh; Ronald Parry
Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine.
Journal of bacteriology 2004;186(1):35-42.
2003: Sarah E O'Connor; Christopher T Walsh; Fei Liu
Biosynthesis of epothilone intermediates with alternate starter units: engineering polyketide-nonribosomal interfaces.
Angewandte Chemie (International ed. in English) 2003;42(33):3917-21.
2003: Christopher T Walsh; Sarah E O'Connor; Tanya L Schneider
Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits.
Journal of industrial microbiology & biotechnology 2003;30(8):448-55.
2002: Tanya L Schneider; Christopher T Walsh; Sarah E O'Connor
Utilization of alternate substrates by the first three modules of the epothilone synthetase assembly line.
Journal of the American Chemical Society 2002;124(38):11272-3.
2002: Sarah E O'Connor; Huawei Chen; Christopher T Walsh
Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces.
Biochemistry 2002;41(17):5685-94.
2002: Huawei Chen; Brian K Hubbard; Sarah E O'Connor; Christopher T Walsh
Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics.
Chemistry & biology 2002;9(1):103-12.
2001: Huawei Chen; Michael G Thomas; Sarah E O'Connor; Brian K Hubbard; Michael D Burkart; Christopher T Walsh
Aminoacyl-S-enzyme intermediates in beta-hydroxylations and alpha,beta-desaturations of amino acids in peptide antibiotics.
Biochemistry 2001;40(39):11651-9.
2001: Huawei Chen; Sarah E O'Connor; D E Cane; Christopher T Walsh
Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit.
Chemistry & biology 2001;8(9):899-912.
2001: Sarah E O'Connor; J Pohlmann; Barbara Imperiali; I Saskiawan; K Yamamoto
Probing the effect of the outer saccharide residues of N-linked glycans on peptide conformation.
Journal of the American Chemical Society 2001;123(25):6187-8.
1999: Barbara Imperiali; Sarah E O'Connor
Effect of N-linked glycosylation on glycopeptide and glycoprotein structure.
Current opinion in chemical biology 1999;3(6):643-9.
1996: Sarah E O'Connor; Barbara Imperiali
Modulation of protein structure and function by asparagine-linked glycosylation.
Chemistry & biology 1996;3(10):803-12.