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Timothy O'Connor

Research Profile

Chemicals & Drugs

Physiology

DNA Repair

Disorders

DNA Damage

Concepts & Ideas

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Publications

TOP 3
Stephanie L Nay; Steven E Bates; Dong-Hyun Lee; Timothy R O'Connor
Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts.
Li Z Luo; Stephanie L Nay; Steven E Bates; Sailesh Gopalakrishna-Pillai; Linda E Iverson; Sang-Won Park; Xianmin Zeng; Timothy R O'Connor
DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells.
Timothy R O'Connor; Gerald P Holmquist
Algorithm for writing a scientific manuscript.

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All Publications

2012: Stephanie L Nay; Steven E Bates; Dong-Hyun Lee; Timothy R O'Connor
Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts.
DNA repair 2012;11(5):502-10.
2012: Li Z Luo; Stephanie L Nay; Steven E Bates; Sailesh Gopalakrishna-Pillai; Linda E Iverson; Sang-Won Park; Xianmin Zeng; Timothy R O'Connor
DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells.
PloS one 2012;7(3):e30541.
2009: Timothy R O'Connor; Gerald P Holmquist
Algorithm for writing a scientific manuscript.
Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology 2009;37(6):344-8.
2008: Malkhey Verma; Hans-Joerg Martin; Wahajul Haq; Timothy R O'Connor; Edmund Maser; Ganesaratnam K Balendiran
Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.
European journal of pharmacology 2008;584(2-3):213-21.
2007: David J Baker; Gerald E Wuenschell; Liqun Xia; John Termini; Steven E Bates; Arthur D Riggs; Timothy R O'Connor
Nucleotide excision repair eliminates unique DNA-protein cross-links from mammalian cells.
The Journal of biological chemistry 2007;282(31):22592-604.
2007: Hyun-Wook Lee; Hae-Jung Lee; Chong-mu Hong; David J Baker; Ravi Bhatia; Timothy R O'Connor
Monitoring repair of DNA damage in cell lines and human peripheral blood mononuclear cells.
Analytical biochemistry 2007;365(2):246-59.
2005: Jung-Hoon Yoon; Purnima Singh; Dong-Hyun Lee; Junzhuan Qiu; Sheng Cai; Timothy R O'Connor; Yuan Chen; Binghui Shen; Gerd P Pfeifer
Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues.
Biochemistry 2005;44(48):15774-86.
2005: Dong-Hyun Lee; Seung-Gi Jin; Sheng Cai; Yuan Chen; Gerd P Pfeifer; Timothy R O'Connor
Repair of methylation damage in DNA and RNA by mammalian AlkB homologues.
The Journal of biological chemistry 2005;280(47):39448-59.
2005: Liqun Xia; Li Zheng; Hyun-Wook Lee; Steven E Bates; Laura Federico; Binghui Shen; Timothy R O'Connor
Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease.
Journal of molecular biology 2005;346(5):1259-74.
2005: Steven E Bates; Ning Ye Zhou; Laura E Federico; Liqun Xia; Timothy R O'Connor
Repair of cyclobutane pyrimidine dimers or dimethylsulfate damage in DNA is identical in normal or telomerase-immortalized human skin fibroblasts.
Nucleic acids research 2005;33(8):2475-85.
2003: Jung-Hoon Yoon; Shigenori Iwai; Timothy R O'Connor; Gerd P Pfeifer
Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair.
Nucleic acids research 2003;31(18):5399-404.
2003: Ning Ye Zhou; Steven E Bates; Mohammed Bouziane; Anne Stary; Alain Sarasin; Timothy R O'Connor
Efficient repair of cyclobutane pyrimidine dimers at mutational hot spots is restored in complemented Xeroderma pigmentosum group C and trichothiodystrophy/xeroderma pigmentosum group D cells.
Journal of molecular biology 2003;332(2):337-51.
2003: Gerald E Wuenschell; Timothy R O'Connor; John Termini
Stability, miscoding potential, and repair of 2'-deoxyxanthosine in DNA: implications for nitric oxide-induced mutagenesis.
Biochemistry 2003;42(12):3608-16.
2002: Chun Ling Jiang; Seung-Gi Jin; Dong Hyun Lee; Zi Jian Lan; Xueping Xu; Timothy R O'Connor; Piroska E Szabó; Jeffrey R Mann; Austin J Cooney; Gerd P Pfeifer
MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.
Genomics 2002;80(6):621-9.
2002: S M Dai; Timothy R O'Connor; Gerald P Holmquist; Arthur D Riggs; S D Flanagan
Ligation-mediated PCR: robotic liquid handling for DNA damage and repair.
BioTechniques 2002;33(5):1090-7.
2002: Dong-Hyun Lee; Timothy R O'Connor; Gerd P Pfeifer
Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG-->TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells.
Nucleic acids research 2002;30(16):3566-73.
2001: Liqun Xia; Timothy R O'Connor
DNA glycosylase activity assay based on streptavidin paramagnetic bead substrate capture.
Analytical biochemistry 2001;298(2):322-6.
2001: Seung-Gi Jin; J H Choi; B Ahn; Timothy R O'Connor; W Mar; Chong-Soon Lee
Excision repair of adozelesin-N3 adenine adduct by 3-methyladenine-DNA glycosylases and UvrABC nuclease.
Molecules and cells 2001;11(1):41-7.
2000: Mohammed Bouziane; Feng Miao; Steven E Bates; L Somsouk; B C Sang; Mikhail F Denissenko; Timothy R O'Connor
Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene.
Mutation research 2000;461(1):15-29.
2000: Feng Miao; Mohammed Bouziane; Reinhard Dammann; C Masutani; F Hanaoka; G Pfeifer; Timothy R O'Connor
3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.
The Journal of biological chemistry 2000;275(37):28433-8.
2000: Piroska E Szabó; Gerd P Pfeifer; Feng Miao; Timothy R O'Connor; Jeffrey R Mann
Improved in vivo dimethyl sulfate footprinting using AlkA protein: DNA-protein interactions at the mouse H19 gene promoter in primary embryo fibroblasts.
Analytical biochemistry 2000;283(1):112-6.
2000: Jung-Hoon Yoon; Chong-Soon Lee; Timothy R O'Connor; A Yasui; Gerd P Pfeifer
The DNA damage spectrum produced by simulated sunlight.
Journal of molecular biology 2000;299(3):681-93.
1998: K H Je; J K Son; Timothy R O'Connor; Chong-Soon Lee
Hepsulfam induced DNA adducts and its excision repair by bacterial and mammalian 3-methyladenine DNA glycosylases.
Molecules and cells 1998;8(6):691-7.
1998: Mikhail F Denissenko; TB Koudriakova; L Smith; Timothy R O'Connor; Arthur D Riggs; Gerd P Pfeifer
The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts.
Oncogene 1998;17(23):3007-14.
1998: N Ye; Gerald P Holmquist; Timothy R O'Connor
Heterogeneous repair of N-methylpurines at the nucleotide level in normal human cells.
Journal of molecular biology 1998;284(2):269-85.
1998: Feng Miao; Mohammed Bouziane; Timothy R O'Connor
Interaction of the recombinant human methylpurine-DNA glycosylase (MPG protein) with oligodeoxyribonucleotides containing either hypoxanthine or abasic sites.
Nucleic acids research 1998;26(17):4034-41.
1998: Mohammed Bouziane; Feng Miao; N Ye; Gerald P Holmquist; G Chyzak; Timothy R O'Connor
Repair of DNA alkylation damage.
Acta biochimica Polonica 1998;45(1):191-202.
1996: William Mattes; C S Lee; Jacques Laval; Timothy R O'Connor
Excision of DNA adducts of nitrogen mustards by bacterial and mammalian 3-methyladenine-DNA glycosylases.
Carcinogenesis 1996;17(4):643-8.
1996: Régen Drouin; Henry Rodriguez; S W Gao; Z Gebreyes; Timothy R O'Connor; Gerald P Holmquist; Steven Akman
Cupric ion/ascorbate/hydrogen peroxide-induced DNA damage: DNA-bound copper ion primarily induces base modifications.
Free radical biology & medicine 1996;21(3):261-73.
1995: Henry Rodriguez; Régen Drouin; Gerald P Holmquist; Timothy R O'Connor; Serge Boiteux; Jacques Laval; James Doroshow; Steven Akman
Mapping of copper/hydrogen peroxide-induced DNA damage at nucleotide resolution in human genomic DNA by ligation-mediated polymerase chain reaction.
The Journal of biological chemistry 1995;270(29):17633-40.
1993: Timothy R O'Connor
Purification and characterization of human 3-methyladenine-DNA glycosylase.
Nucleic acids research 1993;21(24):5561-9.
1993: Timothy R O'Connor; R J Graves; Gilbert de Murcia; Bertrand Castaing; Jacques Laval
Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role.
The Journal of biological chemistry 1993;268(12):9063-70.
1992: R J Graves; Israel Felzenszwalb; Jacques Laval; Timothy R O'Connor
Excision of 5'-terminal deoxyribose phosphate from damaged DNA is catalyzed by the Fpg protein of Escherichia coli.
The Journal of biological chemistry 1992;267(20):14429-35.
1991: Timothy R O'Connor; Jacques Laval
Human cDNA expressing a functional DNA glycosylase excising 3-methyladenine and 7-methylguanine.
Biochemical and biophysical research communications 1991;176(3):1170-7.
1991: Jacques Laval; F Lopès; Jean-Claude Madelmont; D Godenèche; G Meyniel; Y Habraken; Timothy R O'Connor; Serge Boiteux
Excision of imidazole ring-opened N7-hydroxyethylguanine from chloroethylnitrosourea-treated DNA by Escherichia coli formamidopyrimidine-DNA glycosylase.
IARC scientific publications 1991;(105):412-6.
1990: Jacques Laval; Serge Boiteux; Timothy R O'Connor
Physiological properties and repair of apurinic/apyrimidinic sites and imidazole ring-opened guanines in DNA.
Mutation research 1990;233(1-2):73-9.
1990: Serge Boiteux; Timothy R O'Connor; F Lederer; Alain Gouyette; Jacques Laval
Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites.
The Journal of biological chemistry 1990;265(7):3916-22.
1990: Jean-François Constant; A Fkyerat; Martine Demeunynck; Jacques Laval; Timothy R O'Connor; Jean Lhomme
Design of molecules which specifically cleave abasic sites in DNA.
Anti-cancer drug design 1990;5(1):59-62.
1989: Timothy R O'Connor; Jacques Laval
Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5222-6.
1989: Timothy R O'Connor; Serge Boiteux; Jacques Laval
Repair of imidazole ring-opened purines in DNA: overproduction of the formamidopyrimidine-DNA glycosylase of Escherichia coli using plasmids containing the fpg+ gene.
Annali dell'Istituto superiore di sanità 1989;25(1):27-31.
1988: Timothy R O'Connor; Serge Boiteux; Jacques Laval
Ring-opened 7-methylguanine residues in DNA are a block to in vitro DNA synthesis.
Nucleic acids research 1988;16(13):5879-94.
1988: Jean-François Constant; Timothy R O'Connor; Jean Lhomme; Jacques Laval
9-[(10-(aden-9-yl)-4,8-diazadecyl)amino]-6-chloro-2-methoxy-acridine incises DNA at apurinic sites.
Nucleic acids research 1988;16(6):2691-703.
1987: Serge Boiteux; Timothy R O'Connor; Jacques Laval
Formamidopyrimidine-DNA glycosylase of Escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein.
The EMBO journal 1987;6(10):3177-83.