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Michael O'Donovan

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Marian Hamshere; Peter Holmans; Ian Jones; Lesley Jones; K S Kendler; J Kranz; D Morris; T O'Neill; Michael J Owen; S Purcell; A L Richards; B Riley; P Sklar; R Smith; J T R Walters; Aiden Corvin; Nick Craddock; Liz Forty; Michael Gill; Katherine Gordon-Smith; Elaine Green; Detelina Grozeva; Michael C O'Donovan
Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC.
D H Kavanagh; Michael C O'Donovan; Sarah Dwyer; Michael J Owen
The ENCODE project: implications for psychiatric genetics.
Elaine K Green; Detelina Grozeva; Marian Hamshere; Ian Richard Jones; Lesley Jones; Peter McGuffin; J L Moran; Michael C O'Donovan; Michael J Owen; S Purcell; E Russell; P Sklar; Anne Farmer; Liz Forty; Katherine Gordon-Smith; Nick Craddock
Association at SYNE1 in both bipolar disorder and recurrent major depression.

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All Publications

2013: Marian Hamshere; Peter Holmans; Ian Jones; Lesley Jones; K S Kendler; J Kranz; D Morris; T O'Neill; Michael J Owen; S Purcell; A L Richards; B Riley; P Sklar; R Smith; J T R Walters; Aiden Corvin; Nick Craddock; Liz Forty; Michael Gill; Katherine Gordon-Smith; Elaine Green; Detelina Grozeva; Michael C O'Donovan
Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC.
Molecular psychiatry 2013;18(6):708-12.
2013: D H Kavanagh; Michael C O'Donovan; Sarah Dwyer; Michael J Owen
The ENCODE project: implications for psychiatric genetics.
Molecular psychiatry 2013;18(5):540-2.
2013: Elaine K Green; Detelina Grozeva; Marian Hamshere; Ian Richard Jones; Lesley Jones; Peter McGuffin; J L Moran; Michael C O'Donovan; Michael J Owen; S Purcell; E Russell; P Sklar; Anne Farmer; Liz Forty; Katherine Gordon-Smith; Nick Craddock
Association at SYNE1 in both bipolar disorder and recurrent major depression.
Molecular psychiatry 2013;18(5):614-7.
2013: Hywel J Williams; George Kirov; Stephen Monks; Kieran C Murphy; Michael C O'Donovan; Michael J Owen
Schizophrenia two-hit hypothesis in velo-cardio facial syndrome.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2013;162B(2):177-82.
2013: Jade Chapman; Amy Gerrish; Denise Harold; Paul Hollingworth; Peter Holmans; Dobril Ivanov; Michael C O'Donovan; Michael J Owen; Elliott Rees; Rebecca Sims; Alexandra Stretton; Julie Williams; George Kirov
A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk.
Human molecular genetics 2013;22(4):816-24.
2012: Hywel J Williams; Michael J Owen; Sarah Dwyer; Lyudmila Georgieva; George Kirov; Michael C O'Donovan
Absence of de novo point mutations in exons of GRIN2B in a large schizophrenia trio sample.
Schizophrenia research 2012;141(2-3):274-6.
2012: Menachem Fromer; Robert E Handsaker; Christina M Hultman; George Kirov; Steven A McCarroll; Jennifer L Moran; Michael C O'Donovan; Michael J Owen; Eric Banks; Sarah E Bergen; Kimberly Chambert; Douglas M Ruderfer; Pamela Sklar; Patrick F Sullivan; Shaun M Purcell
Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth.
American journal of human genetics 2012;91(4):597-607.
2012: Valentina Moskvina; Nicholas Craddock; Peter Holmans; Michael J Owen; Karl Michael Schmidt; Alexey Vedernikov; Michael C O'Donovan
Permutation-based approaches do not adequately allow for linkage disequilibrium in gene-wide multi-locus association analysis.
European journal of human genetics : EJHG 2012;20(8):890-6.
2012: Detelina Grozeva; Matthew Hurles; George Kirov; Michael C O'Donovan; Michael J Owen; Chris P Barnes; Donald F Conrad; Nick Craddock
Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia.
Schizophrenia research 2012;135(1-3):1-7.
2012: Nicola J Wiles; Philip J Cowen; Victoria Mason; Jean Mulligan; David Nutt; Michael C O'Donovan; Tim J Peters; Deborah Sharp; Deborah Tallon; Laura Thomas; Glyn Lewis
Severity of depression and response to antidepressants: GENPOD randomised controlled trial.
The British journal of psychiatry : the journal of mental science 2012;200(2):130-6.
2012: George Kirov; Noboru H Komiyama; J Moran; Ivan Nikolov; Michael C O'Donovan; P I Olason; A Bayés; Yvonne Böttcher; K Chambert; Jyoti S Choudhary; Mark Collins; E Fernandez; M Fjodorova; Lyudmila Georgieva; S G N Grant; Detelina Grozeva; Peter Holmans; M Ikeda; Dobril Ivanov; Andrew J Pocklington; S Purcell; E Rees; D Ruderfer; P Sklar; Hreinn Stefansson; K Stefansson; Draga Toncheva; R Wollerton; Louie van de Lagemaat; Michael J Owen
De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.
Molecular psychiatry 2012;17(2):142-53.
2012: A L Richards; A R Sanders; P M Visscher; Michael J Owen; S Purcell; Nick Craddock; P V Gejman; Peter Holmans; Lesley Jones; George Kirov; Douglas F Levinson; Valentina Moskvina; Michael C O'Donovan
Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain.
Molecular psychiatry 2012;17(2):193-201.
2011: Elliott Rees; Valentina Moskvina; Michael C O'Donovan; Michael J Owen; George Kirov
De novo rates and selection of schizophrenia-associated copy number variants.
Biological psychiatry 2011;70(12):1109-14.
2011: Valentina Moskvina; Nick Craddock; Peter Holmans; Colm O'Dushlaine; Shaun Purcell; Michael C O'Donovan
Evaluation of an approximation method for assessment of overall significance of multiple-dependent tests in a genomewide association study.
Genetic epidemiology 2011;35(8):861-6.
2011: Marian Hamshere; Peter Holmans; Lisa A Jones; Geraldine M McCarthy; Peter McGuffin; Kieran C Murphy; Nadine Norton; Michael C O'Donovan; Michael J Owen; Robert D Sanders; Hywel J Williams; Nigel M Williams; Stanley Zammit; Nicholas Craddock; MY Gray; Alastair G Cardno
Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2011;156B(8):929-40.
2011: L S Carroll; George Kirov; Michael C O'Donovan; J Walters; Hywel J Williams; Michael J Owen
Mutation screening of the 3q29 microdeletion syndrome candidate genes DLG1 and PAK2 in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2011;156B(7):844-9.
2011: Hywel J Williams; Sarah Dwyer; Valentina Moskvina; Michael J Owen; Giancarlo Russo; Rhodri L Smith; Michael C O'Donovan
Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2011;156B(7):781-4.
2011: Stefania Tognin; Essi Viding; Eamon J McCrory; Philip McGuire; Michael C O'Donovan; Lauren Taylor; Andrea Mechelli
Effects of DTNBP1 genotype on brain development in children.
Journal of child psychology and psychiatry, and allied disciplines 2011;52(12):1287-94.
2011: A Yosifova; I Zaharieva; Ivanka Dimova; I Gerdjikov; S Hadjidekova; N Kamatani; Y Kamatani; S Karachanak; George Kirov; M Kubo; N Madjirova; vihra milanova; Taisei Mushiroda; Michael C O'Donovan; Michael J Owen; N Poryazova; D Stoianov; A Takahashi; T Tolev; Draga Toncheva; R Vazharova; Y Nakamura
Genome-wide association study on bipolar disorder in the Bulgarian population.
Genes, brain, and behavior 2011;10(7):789-97.
2011: Sarah Dwyer; Ian Jones; Lesley Jones; Michael J Owen; J Walters; H Williams; Nick Craddock; Michael C O'Donovan
Investigation of rare non-synonymous variants at ABCA13 in schizophrenia and bipolar disorder.
Molecular psychiatry 2011;16(8):790-1.
2011: Valentina Moskvina; Bertram Müller-Myhsok; Michael J Owen; Nick Craddock; Elaine Green; Peter Holmans; Tony Kam-Thong; Michael C O'Donovan
An examination of single nucleotide polymorphism selection prioritization strategies for tests of gene-gene interaction.
Biological psychiatry 2011;70(2):198-203.
2011: Rhodri Ll Smith; Hywel Williams; Alex Richards; Sarah Dwyer; George Kirov; Deborah Knight; Michael C O'Donovan; Michael J Owen
Analysis of neurogranin (NRGN) in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2011;156B(5):532-5.
2011: Elaine K Green; Detelina Grozeva; R Sims; Rachel Raybould; Liz Forty; Katherine Gordon-Smith; E Russell; D St Clair; A H Young; Ian Nicol Ferrier; George Kirov; Ian Jones; Lesley Jones; Michael J Owen; Michael C O'Donovan; Nick Craddock
DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2011;156B(4):490-2.
2011: Glyn Lewis; Jean Mulligan; Nicola J Wiles; Philip Cowen; Nick Craddock; Masashi Ikeda; Detelina Grozeva; Victoria Mason; David Nutt; Deborah Sharp; Debbie Tallon; Laura Thomas; Michael C O'Donovan; Tim J Peters
Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial.
The British journal of psychiatry : the journal of mental science 2011;198(6):464-71.
2011: Marian Hamshere; Peter Holmans; Ian Richard Jones; Lesley Jones; George Kirov; Peter McGuffin; Andrew McQuillin; Valentina Moskvina; Michael C O'Donovan; Michael J Owen; S Purcell; P Sklar; D St Clair; A H Young; Anne Farmer; Ian Nicol Ferrier; Elaine K Green; Detelina Grozeva; H Gurling; N Bass; Nick Craddock
Polygenic dissection of the bipolar phenotype.
The British journal of psychiatry : the journal of mental science 2011;198(4):284-8.
2011: E Stergiakouli; Kate Langley; Hywel Williams; J Walters; Nigel M Williams; S Suren; Ina Giegling; Lawrence S Wilkinson; Michael J Owen; Michael C O'Donovan; Dan Rujescu; Anita Thapar; William Davies
Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder.
Genes, brain, and behavior 2011;10(3):334-44.
2011: Michael J Owen; Michael C O'Donovan; Anita Thapar; Nicholas Craddock
Neurodevelopmental hypothesis of schizophrenia.
The British journal of psychiatry : the journal of mental science 2011;198(3):173-5.
2011: Masashi Ikeda; Branko Aleksic; Yoko Kinoshita; Tomo Okochi; Kunihiro Kawashima; Itaru Kushima; Yoshihito Ito; Yukako Nakamura; Taro Kishi; Takenori Okumura; Yasuhisa Fukuo; Hywel J Williams; Marian L Hamshere; Dobril Ivanov; Toshiya INADA; Michio Suzuki; Ryota Hashimoto; Hiroshi Ujike; Masatoshi Takeda; Nick Craddock; Kozo Kaibuchi; Michael J Owen; Norio Ozaki; Michael C O'Donovan; Nakao Iwata
Genome-wide association study of schizophrenia in a Japanese population.
Biological psychiatry 2011;69(5):472-8.
2011: Hywel J Williams; Nick Craddock; Giancarlo Russo; Marian L Hamshere; Valentina Moskvina; Sarah Dwyer; Rhodri L Smith; Elaine Green; Detelina Grozeva; Peter Holmans; Michael J Owen; Michael C O'Donovan
Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries.
Human molecular genetics 2011;20(2):387-91.
2010: Sarah Dwyer; Hywel Williams; Peter Holmans; Valentina Moskvina; Nick Craddock; Michael J Owen; Michael C O'Donovan
No evidence that rare coding variants in ZNF804A confer risk of schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(8):1411-6.
2010: Kate Langley; Jessica Heron; Michael C O'Donovan; Michael J Owen; Anita Thapar
Genotype link with extreme antisocial behavior: the contribution of cognitive pathways.
Archives of general psychiatry 2010;67(12):1317-23.
2010: L S Carroll; Nigel M Williams; Valentina Moskvina; E Russell; Nadine Norton; Hywel J Williams; Tim Peirce; Lyudmila Georgieva; Sarah Dwyer; Detelina Grozeva; E Greene; Anne Farmer; Peter McGuffin; Derek W Morris; Aiden Corvin; Michael Gill; Dan Rujescu; Pak Sham; Peter Holmans; Ian Jones; George Kirov; Nick Craddock; Michael C O'Donovan; Michael J Owen
Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha.
Molecular psychiatry 2010;15(11):1101-11.
2010: Elaine K Green; Detelina Grozeva; Valentina Moskvina; Marian Hamshere; Ian R Jones; Lisa Jones; Liz Forty; Sian Caesar; Katherine Gordon-Smith; Christine Fraser; Ellie Russell; David St Clair; Allan H Young; Nicol Ferrier; Anne Farmer; Peter McGuffin; Peter Holmans; Michael J Owen; Michael C O'Donovan; Nick Craddock
Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(7):1347-9.
2010: Elaine K Green; Detelina Grozeva; Ian Jones; Lesley Jones; George Kirov; Sian Caesar; Katherine Gordon-Smith; C Fraser; Liz Forty; E Russell; Marian Hamshere; Valentina Moskvina; Ivan Nikolov; Anne Farmer; Peter McGuffin; Peter Holmans; Michael J Owen; Michael C O'Donovan; Nick Craddock
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia.
Molecular psychiatry 2010;15(10):1016-22.
2010: Alistair T Pagnamenta; Elena Bacchelli; Maretha V de Jonge; Ghazala Mirza; Thomas Scerri; Fiorella Minopoli; Andreas Chiocchetti; Kerstin U Ludwig; Per Hoffmann; Silvia Paracchini; Ernesto Lowy; Denise H Harold; Jade A Chapman; Sabine M Klauck; Fritz Poustka; Renske H Houben; Wouter G Staal; Roel A Ophoff; Michael C O'Donovan; Julie Williams; Markus M Nöthen; Gerd Schulte-Körne; Panos Deloukas; Jiannis Ragoussis; Anthony J Bailey; Elena Maestrini; Anthony P Monaco
Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia.
Biological psychiatry 2010;68(4):320-8.
2010: Masashi Ikeda; Nigel Williams; Hywel J Williams; Rhodri Smith; Stephen Monks; Michael J Owen; Kieran C Murphy; Michael C O'Donovan
Failure to confirm association between PIK4CA and psychosis in 22q11.2 deletion syndrome.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(4):980-2.
2010: Sarah Dwyer; L Carroll; Kiran K Mantripragada; Michael J Owen; Michael C O'Donovan; Nigel M Williams
Mutation screening of the DTNBP1 exonic sequence in 669 schizophrenics and 710 controls using high-resolution melting analysis.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(3):766-74.
2010: Detelina Grozeva; George Kirov; Dobril Ivanov; Ian Richard Jones; Lisa Jones; Elaine K Green; David M St Clair; Allan H Young; Nicol Ferrier; Anne E Farmer; Peter McGuffin; Peter Holmans; Michael J Owen; Michael C O'Donovan; Nick Craddock
Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia.
Archives of general psychiatry 2010;67(4):318-27.
2010: Kate Langley; Tom Fowler; Tamsin Ford; Ajay K Thapar; Marianne B M van den Bree; Gordon Harold; Michael J Owen; Michael C O'Donovan; Anita Thapar
Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder.
The British journal of psychiatry : the journal of mental science 2010;196(3):235-40.
2010: Masashi Ikeda; Branko Aleksic; George Kirov; Yoko Kinoshita; Yoshio Yamanouchi; Tsuyoshi Kitajima; Kunihiro Kawashima; Tomo Okochi; Taro Kishi; Irina Zaharieva; Michael J Owen; Michael C O'Donovan; Norio Ozaki; Nakao Iwata
Copy number variation in schizophrenia in the Japanese population.
Biological psychiatry 2010;67(3):283-6.
2010: Masashi Ikeda; Yasuyuki Tomita; Akihiro Mouri; Minori Koga; Tomo Okochi; Reiji Yoshimura; Yoshio Yamanouchi; Yoko Kinoshita; Ryota Hashimoto; Hywel J Williams; Masatoshi Takeda; Jun Nakamura; Toshitaka Nabeshima; Michael J Owen; Michael C O'Donovan; Hiroyuki Honda; Tadao Arinami; Norio Ozaki; Nakao Iwata
Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.
Biological psychiatry 2010;67(3):263-9.
2010: Nick Craddock; Lesley Jones; I R Jones; George Kirov; Elaine K Green; Detelina Grozeva; Valentina Moskvina; Ivan Nikolov; Marian Hamshere; D Vukcevic; Sian Caesar; Katherine Gordon-Smith; C Fraser; E Russell; Nadine Norton; Gerome Breen; D St Clair; David A Collier; A H Young; Ian Nicol Ferrier; Anne Farmer; Peter McGuffin; Peter Holmans; P Donnelly; Michael J Owen; Michael C O'Donovan
Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.
Molecular psychiatry 2010;15(2):146-53.
2009: Richard Abraham; Rebecca Sims; Liam Carroll; Paul Hollingworth; Michael C O'Donovan; Julie Williams; Michael J Owen
An association study of common variation at the MAPT locus with late-onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(8):1152-5.
2009: Elaine K Green; Detelina Grozeva; Rachel Raybould; Gareth P Elvidge; Stuart Macgregor; Ian Craig; Anne Farmer; Peter McGuffin; Liz Forty; Lisa Jones; Ian Jones; Michael C O'Donovan; Michael J Owen; George Kirov; Nick Craddock
P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(8):1063-9.
2009: Tom Fowler; Kate Langley; Frances Rice; Marianne B M van den Bree; Kenny Ross; Lawrence S Wilkinson; Michael J Owen; Michael C O'Donovan; Anita Thapar
Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity.
Psychiatric genetics 2009;19(6):312-9.
2009: L S Carroll; K Kendall; Michael C O'Donovan; Michael J Owen; Nigel M Williams
Evidence that putative ADHD low risk alleles at SNAP25 may increase the risk of schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(7):893-9.
2009: Jesse B G Hayesmoore; Nicholas J Bray; William C Cross; Michael J Owen; Michael C O'Donovan; Huw R Morris
The effect of age and the H1c MAPT haplotype on MAPT expression in human brain.
Neurobiology of aging 2009;30(10):1652-6.
2009: R Sims; Paul Hollingworth; Valentina Moskvina; K Dowzell; Michael C O'Donovan; John Powell; Simon Lovestone; Carol Brayne; David C Rubinsztein; Michael J Owen; Julie Williams; Richard Abraham
Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease.
Neuroscience letters 2009;461(1):54-9.
2009: George Kirov; Dan Rujescu; Andres Ingason; David A Collier; Michael C O'Donovan; Michael J Owen
Neurexin 1 (NRXN1) deletions in schizophrenia.
Schizophrenia bulletin 2009;35(5):851-4.
2009: Adelina Yosifova; Taisei Mushiroda; Drozdstoi Stoianov; Radoslava Vazharova; Ivanka Dimova; Sena Karachanak; Irina Zaharieva; vihra milanova; Nadejda Madjirova; Ivan Gerdjikov; Todor Tolev; Stoyanka Velkova; George Kirov; Michael J Owen; Michael C O'Donovan; Draga Toncheva; Yusuke Nakamura
Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.
Journal of affective disorders 2009;117(1-2):87-97.
2009: George Kirov; I Zaharieva; Lyudmila Georgieva; Valentina Moskvina; Ivan Nikolov; Sven Cichon; A Hillmer; D Toncheva; Michael J Owen; Michael C O'Donovan
A genome-wide association study in 574 schizophrenia trios using DNA pooling.
Molecular psychiatry 2009;14(8):796-803.
2009: Marian Hamshere; Elaine K Green; I R Jones; Lesley Jones; Valentina Moskvina; George Kirov; Detelina Grozeva; Ivan Nikolov; D Vukcevic; Sian Caesar; Katherine Gordon-Smith; C Fraser; E Russell; Gerome Breen; D St Clair; D A Collier; A H Young; Ian Nicol Ferrier; Anne Farmer; Peter McGuffin; Peter Holmans; Michael J Owen; Michael C O'Donovan; Nick Craddock
Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept.
The British journal of psychiatry : the journal of mental science 2009;195(1):23-9.
2009: Michael C O'Donovan; Michael J Owen
Genetics and the brain: many pathways to enlightenment.
Human genetics 2009;126(1):1-2.
2009: Peter Holmans; Elaine K Green; Jaspreet Singh Pahwa; Manuel A R Ferreira; Shaun M Purcell; Pamela Sklar; Michael J Owen; Michael C O'Donovan; Nick Craddock
Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder.
American journal of human genetics 2009;85(1):13-24.
2009: Michael C O'Donovan; Nick J Craddock; Michael J Owen
Genetics of psychosis; insights from views across the genome.
Human genetics 2009;126(1):3-12.
2009: Michael E Talkowski; Lora McClain; Trina Allen; L Dianne Bradford; Monica Calkins; Neil Edwards; Lyudmila Georgieva; Rodney Go; Ruben Gur; Raquel Gur; George Kirov; Kodavali V Chowdari; Joseph Kwentus; Paul Lyons; Hader A Mansour; Joseph McEvoy; Michael C O'Donovan; Judith O'Jile; Michael J Owen; Alberto B Santos; Robert Savage; Draga Toncheva; Gerard Vockley; Joel Wood; Bernie Devlin; Vishwajit L Nimgaonkar
Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(4):560-9.
2009: Michael J Owen; Hywel J Williams; Michael C O'Donovan
Schizophrenia genetics: advancing on two fronts.
Current opinion in genetics & development 2009;19(3):266-70.
2009: George Kirov; Detelina Grozeva; Nadine Norton; Dobril Ivanov; Kiran K Mantripragada; Peter Holmans; Nick Craddock; Michael J Owen; Michael C O'Donovan
Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.
Human molecular genetics 2009;18(8):1497-503.
2009: V Moskvina; Nick Craddock; Peter Holmans; Ivan Nikolov; J S Pahwa; Elaine Green; Michael J Owen; Michael C O'Donovan
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.
Molecular psychiatry 2009;14(3):252-60.
2009: A R Morgan; Paul Hollingworth; Richard Abraham; Simon Lovestone; Carol Brayne; David C Rubinsztein; A Lynch; Brian A Lawlor; Michael Gill; Michael C O'Donovan; Michael J Owen; Julie Williams
Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(1):61-4.
2009: Hywel J Williams; Michael J Owen; Michael C O'Donovan
Schizophrenia genetics: new insights from new approaches.
British medical bulletin 2009;91():61-74.
2009: Tom Fowler; Kate Langley; Frances Rice; Naureen Whittinger; Kenny Ross; Stephanie van Goozen; Michael J Owen; Michael C O'Donovan; Marianne B M van den Bree; Anita Thapar
Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder.
The British journal of psychiatry : the journal of mental science 2009;194(1):62-7.
2009: A Gerrish; Hywel Williams; Valentina Moskvina; Michael J Owen; Michael C O'Donovan; Nigel M Williams
An examination of MUTED as a schizophrenia susceptibility gene.
Schizophrenia research 2009;107(1):110-1.
2009: Kate Langley; Tom Fowler; Deborah L Grady; Robert K Moyzis; Peter A Holmans; Marianne B M van den Bree; Michael J Owen; Michael C O'Donovan; Anita Thapar
Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder.
European child & adolescent psychiatry 2009;18(1):26-32.
2008: Michael C O'Donovan; George Kirov; Michael J Owen
Phenotypic variations on the theme of CNVs.
Nature genetics 2008;40(12):1392-3.
2008: Michael C O'Donovan; Nick Craddock; Michael J Owen
Schizophrenia: complex genetics, not fairy tales.
Psychological medicine 2008;38(12):1697-9; discussion 1818-20.
2008: J B G Hayesmoore; Nicholas J Bray; Michael J Owen; Michael C O'Donovan
DISC1 mRNA expression is not influenced by common Cis-acting regulatory polymorphisms or imprinting.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(7):1065-9.
2008: Nigel M Williams; Hywel Williams; Elisa Majounie; Nadine Norton; Beate Glaser; Huw R Morris; Michael J Owen; Michael C O'Donovan
Analysis of copy number variation using quantitative interspecies competitive PCR.
Nucleic acids research 2008;36(17):e112.
2008: Lyudmila Georgieva; Albena Dimitrova; Dobril Ivanov; Ivan Nikolov; Nigel M Williams; Detelina Grozeva; Irina Zaharieva; Draga Toncheva; Michael J Owen; George Kirov; Michael C O'Donovan
Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia.
Biological psychiatry 2008;64(5):419-27.
2008: Nicholas J Bray; Peter Holmans; Marianne B M van den Bree; Lesley Jones; Lyn A Elliston; Gareth Hughes; Alexander L Richards; Nigel M Williams; Nick Craddock; Michael J Owen; Michael C O'Donovan
Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1.
Human molecular genetics 2008;17(8):1169-74.
2008: Yonghong Li; Andrew Grupe; Charles Rowland; Peter Holmans; Ricardo Segurado; Richard Abraham; Lesley Jones; Joseph J Catanese; David Ross; Kevin Mayo; Maribel Martinez; Paul Hollingworth; Alison Goate; Nigel J Cairns; Brad A Racette; Joel S Perlmutter; Michael C O'Donovan; John C Morris; Carol Brayne; David C Rubinsztein; Simon Lovestone; Leon J Thal; Michael J Owen; Julie Williams
Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease.
Human molecular genetics 2008;17(5):759-67.
2008: Michael E Talkowski; George Kirov; Mikhil Bamne; Lyudmila Georgieva; Gonzalo Torres; Hader A Mansour; Kodavali V Chowdari; vihra milanova; Joel Wood; Lora McClain; Konasale Prasad; Brian H Shirts; Jianping Zhang; Michael C O'Donovan; Michael J Owen; Bernie Devlin; Vishwajit L Nimgaonkar
A network of dopaminergic gene variations implicated as risk factors for schizophrenia.
Human molecular genetics 2008;17(5):747-58.
2008: Nigel M Williams; Beate Glaser; Nadine Norton; Hywel Williams; Timothy Pierce; Valentina Moskvina; Stephen Monks; Jurgen Del-Favero; Dirk Goossens; Dan Rujescu; Ina Giegling; George Kirov; Nicholas Craddock; Kieran C Murphy; Michael C O'Donovan; Michael J Owen
Strong evidence that GNB1L is associated with schizophrenia.
Human molecular genetics 2008;17(4):555-66.
2008: George Kirov; Gumus Gumus; Wei Chen; Nadine Norton; Lyudmila Georgieva; Murat Sari; Michael C O'Donovan; Fikret Erdogan; Michael J Owen; Hans-Hilger Ropers; Reinhard Ullmann
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia.
Human molecular genetics 2008;17(3):458-65.
2008: Yonghong Li; Charles Rowland; Joseph J Catanese; John C Morris; Simon Lovestone; Michael C O'Donovan; Alison Goate; Michael J Owen; Julie Williams; Andrew Grupe
SORL1 variants and risk of late-onset Alzheimer's disease.
Neurobiology of disease 2008;29(2):293-6.
2008: Joseph Buxbaum; Lyudmila Georgieva; J J Young; C Plescia; Y Kajiwara; Y Jiang; Valentina Moskvina; Nadine Norton; Tim Peirce; Hywel Williams; Nick Craddock; L Carroll; Gabriel Corfas; Kenneth L Davis; Michael J Owen; Sheila Harroch; T Sakurai; Michael C O'Donovan
Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene.
Molecular psychiatry 2008;13(2):162-72.
2008: Kate Langley; Darko Turic; Frances Rice; Peter Holmans; Marianne B M van den Bree; Nick Craddock; Lindsey Kent; Michael J Owen; Michael C O'Donovan; Anita Thapar
Testing for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(1):49-53.
2008: Alexander L Richards; Peter Holmans; Michael C O'Donovan; Michael J Owen; Lesley Jones
A comparison of four clustering methods for brain expression microarray data.
BMC bioinformatics 2008;9():490.
2008: Richard Abraham; Valentina Moskvina; Rebecca Sims; Paul Hollingworth; Angharad Morgan; Lyudmila Georgieva; Kimberley Dowzell; Sven Cichon; Axel M Hillmer; Michael C O'Donovan; Julie Williams; Michael J Owen; George Kirov
A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.
BMC medical genomics 2008;1():44.
2008: Irina Zaharieva; Lyudmila Georgieva; Ivan Nikolov; George Kirov; Michael J Owen; Michael C O'Donovan; Draga Toncheva
Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping.
BMC psychiatry 2008;8():11.
2007: Hywel J Williams; Nadine Norton; Tim Peirce; Sarah Dwyer; Nigel M Williams; Valentina Moskvina; Michael J Owen; Michael C O'Donovan
Association analysis of the glial cell line-derived neurotrophic factor (GDNF) gene in schizophrenia.
Schizophrenia research 2007;97(1-3):271-6.
2007: Anita Thapar; Kate Langley; Michael J Owen; Michael C O'Donovan
Advances in genetic findings on attention deficit hyperactivity disorder.
Psychological medicine 2007;37(12):1681-92.
2007: Stanley Zammit; Gillian Spurlock; Hywel Williams; Nadine Norton; Nigel Williams; Michael C O'Donovan; Michael J Owen
Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use.
The British journal of psychiatry : the journal of mental science 2007;191():402-7.
2007: Paul Hollingworth; Marian Hamshere; Peter Holmans; Michael C O'Donovan; Rebecca Sims; John Powell; Simon Lovestone; Amanda Myers; FW DeVrieze; John Hardy; Alison Goate; Michael J Owen; Julie Williams
Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(7):841-8.
2007: A R Morgan; Darko Turic; Luke Jehu; Gillian Hamilton; Paul Hollingworth; Valentina Moskvina; Lesley Jones; Simon Lovestone; Carol Brayne; David C Rubinsztein; Brian A Lawlor; Michael Gill; Michael C O'Donovan; Michael J Owen; Julie Williams
Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(6):762-70.
2007: Nadine Norton; Hywel J Williams; Sarah Dwyer; Liam Carroll; Tim Peirce; Valentina Moskvina; Ricardo Segurado; Ivan Nikolov; Nigel M Williams; Masashi Ikeda; Nakao Iwata; Michael J Owen; Michael C O'Donovan
Association analysis of AKT1 and schizophrenia in a UK case control sample.
Schizophrenia research 2007;93(1-3):58-65.
2007: Gillian Hamilton; Petra Proitsi; Luke Jehu; Angharad Morgan; Julie Williams; Michael C O'Donovan; Michael J Owen; John F Powell; Simon Lovestone
Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(4):508-16.
2007: Denise Harold; Luke Jehu; Darko Turic; Paul Hollingworth; Pamela Moore; P Summerhayes; Valentina Moskvina; Catherine Foy; Nicola Archer; B A Hamilton; Simon Lovestone; John Powell; Carol Brayne; David C Rubinsztein; Lesley Jones; Michael C O'Donovan; Michael J Owen; Julie Williams
Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(4):448-52.
2007: Hywel J Williams; Michael J Owen; Michael C O'Donovan
Is COMT a susceptibility gene for schizophrenia?
Schizophrenia bulletin 2007;33(3):635-41.
2007: Nick Craddock; Michael C O'Donovan; Michael J Owen
Phenotypic and genetic complexity of psychosis. Invited commentary on ... Schizophrenia: a common disease caused by multiple rare alleles.
The British journal of psychiatry : the journal of mental science 2007;190():200-3.
2007: David Gunnell; Shon Lewis; J Wilkinson; Lyudmila Georgieva; G Smith Davey; Ian N M Day; Jeff M P Holly; Michael C O'Donovan; Michael J Owen; George Kirov; Stanley Zammit
IGF1, growth pathway polymorphisms and schizophrenia: a pooling study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(1):117-20.
2007: Valentina Moskvina; Michael C O'Donovan
Detailed analysis of the relative power of direct and indirect association studies and the implications for their interpretation.
Human heredity 2007;64(1):63-73.
2006: Denise Harold; Silvia Paracchini; Thomas Scerri; M Dennis; Natalie Cope; Gary Hill; Valentina Moskvina; J Walter; Alexandra Richardson; Michael J Owen; John Stein; Eric Green; Michael C O'Donovan; Julie Williams; Anthony P Monaco
Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.
Molecular psychiatry 2006;11(12):1085-91, 1061.
2006: Beate Glaser; Valentina Moskvina; George Kirov; Kieran C Murphy; Hywel Williams; Nigel Williams; Michael J Owen; Michael C O'Donovan
Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility.
Schizophrenia research 2006;87(1-3):21-7.
2006: Stanley Zammit; Glyn Lewis; Anita Thapar; Richard Owen; Gaynor Jones; Susan Jones; Rob Sanders; Charis Milham; Ameera Mahdi; Michael C O'Donovan; Michael J Owen
Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia.
Journal of psychiatric research 2006;40(7):622-6.
2006: Elaine K Green; Nadine Norton; Tim Peirce; Detelina Grozeva; George Kirov; Michael J Owen; Michael C O'Donovan; Nick Craddock
Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation.
Molecular psychiatry 2006;11(9):798-9.
2006: Lyudmila Georgieva; Valentina Moskvina; Tim Peirce; Nadine Norton; Nicholas J Bray; Lesley Jones; Peter Holmans; Stuart Macgregor; Stanley Zammit; Jennifer Wilkinson; Hywel Williams; Ivan Nikolov; Nigel Williams; Dobril Ivanov; Kenneth L Davis; Vahram Haroutunian; Joseph Buxbaum; Nick Craddock; George Kirov; Michael J Owen; Michael C O'Donovan
Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(33):12469-74.
2006: Nicholas J Bray; Michael C O'Donovan
Investigating cis-acting regulatory variation using assays of relative allelic expression.
Psychiatric genetics 2006;16(4):173-7.
2006: Marian Hamshere; Nigel M Williams; Nadine Norton; Hywel Williams; Alastair G Cardno; Stanley Zammit; Lisa Anne Jones; Kieran C Murphy; Robert D Sanders; G McCarthy; MY Gray; G Jones; Peter Holmans; Michael C O'Donovan; Michael J Owen; Nick Craddock
Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes.
Journal of medical genetics 2006;43(7):563-7.
2006: Gillian Hamilton; Farzana Samedi; Jo Knight; Nicola Archer; Catherine Foy; Sarah Walter; Darko Turic; Luke Jehu; Pamela Moore; Paul Hollingworth; Michael C O'Donovan; Julie Williams; Michael J Owen; Simon Lovestone; John F Powell
Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease.
Neuroscience letters 2006;401(1-2):77-80.
2006: Julie Williams; Michael C O'Donovan
The genetics of developmental dyslexia.
European journal of human genetics : EJHG 2006;14(6):681-9.
2006: Nick Craddock; Michael J Owen; Michael C O'Donovan
The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons.
Molecular psychiatry 2006;11(5):446-58.
2006: Nigel M Williams; Elaine K Green; Stuart Macgregor; Sarah Dwyer; Nadine Norton; Hywel Williams; Rachel Raybould; Detelina Grozeva; Marian Hamshere; Stanley Zammit; Lisa Jones; Alastair G Cardno; George Kirov; Ian Jones; Michael C O'Donovan; Michael J Owen; Nick Craddock
Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder.
Archives of general psychiatry 2006;63(4):366-73.
2006: Nadine Norton; Valentina Moskvina; Derek W Morris; Nicholas J Bray; Stanley Zammit; Nigel M Williams; Hywel J Williams; Anna Preece; Sarah Dwyer; Jennifer C Wilkinson; Gillian Spurlock; George Kirov; Paul R Buckland; John L Waddington; Michael Gill; Aiden Corvin; Michael J Owen; Michael C O'Donovan
Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(1):96-101.
2006: Imtiaz A Khan; Matthew Mort; Paul R Buckland; Michael C O'Donovan; David N Cooper; Nadia Chuzhanova
In silico discrimination of single nucleotide polymorphisms and pathological mutations in human gene promoter regions by means of local DNA sequence context and regularity.
In silico biology 2006;6(1-2):23-34.
2006: Nigel M Williams; Michael C O'Donovan; Michael J Owen
Chromosome 22 deletion syndrome and schizophrenia.
International review of neurobiology 2006;73():1-27.
2006: Valentina Moskvina; Nick Craddock; Peter Holmans; Michael J Owen; Michael C O'Donovan
Effects of differential genotyping error rate on the type I error probability of case-control studies.
Human heredity 2006;61(1):55-64.
2006: George Kirov; Ivan Nikolov; Lyudmila Georgieva; Valentina Moskvina; Michael J Owen; Michael C O'Donovan
Pooled DNA genotyping on Affymetrix SNP genotyping arrays.
BMC genomics 2006;7():27.
2006: Tim Peirce; Nicholas J Bray; Nigel M Williams; Nadine Norton; Valentina Moskvina; Anna Preece; Vahram Haroutunian; Joseph Buxbaum; Michael J Owen; Michael C O'Donovan
Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia.
Archives of general psychiatry 2006;63(1):18-24.
2006: Elaine K Green; Rachel Raybould; Stuart Macgregor; Sally Hyde; Allan H Young; Michael C O'Donovan; Michael J Owen; George Kirov; Lisa Jones; Ian Jones; Nick Craddock
Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK.
The British journal of psychiatry : the journal of mental science 2006;188():21-5.
2006: Nick Craddock; Michael C O'Donovan; Michael J Owen
Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology.
Schizophrenia bulletin 2006;32(1):9-16.
2006: Scott Smemo; Petra Nowotny; Anthony L Hinrichs; John S K Kauwe; Sara Cherny; Katherine Erickson; Amanda Myers; Mona Kaleem; Lauren Marlowe; Alison M Gibson; Paul Hollingworth; Michael C O'Donovan; Christopher M Morris; Peter Holmans; Simon Lovestone; John C Morris; Leon J Thal; Yonghong Li; Andrew Grupe; John Hardy; Michael J Owen; Julie Williams; Alison Goate
Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease.
Annals of neurology 2006;59(1):21-6.
2005: Kate Langley; Darko Turic; Tim Peirce; Sophie Mills; Marianne B M van den Bree; Michael J Owen; Michael C O'Donovan; Anita Thapar
No support for association between the dopamine transporter (DAT1) gene and ADHD.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;139B(1):7-10.
2005: Marian Hamshere; Philip Bennett; Nigel Williams; Ricardo Segurado; Alastair G Cardno; Nadine Norton; David Lambert; Hywel Williams; George Kirov; Aiden Corvin; Peter Holmans; Lisa Jones; Ian Jones; Michael Gill; Michael C O'Donovan; Michael J Owen; Nick Craddock
Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13.
Archives of general psychiatry 2005;62(10):1081-8.
2005: Nigel M Williams; Michael C O'Donovan; Michael J Owen
Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?
Schizophrenia bulletin 2005;31(4):800-5.
2005: B Glaser; George Kirov; Nicholas J Bray; Elaine Green; Michael C O'Donovan; Nick Craddock; Michael J Owen
Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4.
Molecular psychiatry 2005;10(10):920-7.
2005: Lindsey Kent; Elaine Green; Ziarih Hawi; Aiveen Kirley; Frank Dudbridge; Naomi Lowe; Rachel Raybould; Kate Langley; Nicholas J Bray; Michael Fitzgerald; Michael J Owen; Michael C O'Donovan; Michael Gill; Anita Thapar; Nick Craddock
Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD.
Molecular psychiatry 2005;10(10):939-43.
2005: Hywel J Williams; Beate Glaser; Nigel M Williams; Nadine Norton; Stanley Zammit; Stuart Macgregor; George Kirov; Michael J Owen; Michael C O'Donovan
No association between schizophrenia and polymorphisms in COMT in two large samples.
The American journal of psychiatry 2005;162(9):1736-8.
2005: Paul R Buckland; Bastiaan Hoogendoorn; Sharon L Coleman; Carol A Guy; S Kaye Smith; Michael C O'Donovan
Strong bias in the location of functional promoter polymorphisms.
Human mutation 2005;26(3):214-23.
2005: Michael J Owen; Nick Craddock; Michael C O'Donovan
Schizophrenia: genes at last?
Trends in genetics : TIG 2005;21(9):518-25.
2005: Nicholas J Bray; Anna Preece; Nigel M Williams; Valentina Moskvina; Paul R Buckland; Michael J Owen; Michael C O'Donovan
Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression.
Human molecular genetics 2005;14(14):1947-54.
2005: Petra Nowotny; Anthony L Hinrichs; Scott Smemo; John S K Kauwe; Taylor Maxwell; Peter Holmans; Marian Hamshere; Darko Turic; Luke Jehu; Paul Hollingworth; Pamela Moore; Leslie Bryden; Amanda Myers; Lisa M Doil; Kristina M Tacey; Alison M Gibson; Ian G McKeith; Robert H Perry; Christopher M Morris; Leon J Thal; John C Morris; Michael C O'Donovan; Simon Lovestone; Andrew Grupe; John Hardy; Michael J Owen; Julie Williams; Alison Goate
Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;136B(1):62-8.
2005: Beate Glaser; Johannes Schumacher; Hywel J Williams; Rami Abou Jamra; Nikolai Ianakiev; Radoi Milev; Stephanie Ohlraun; Thomas G. Schulze; Piotr M Czerski; Joanna Hauser; Erik G Jönsson; Göran C Sedvall; Norman Klopp; Thomas Illig; Tim Becker; Peter Propping; Nigel M Williams; Sven Cichon; George Kirov; Marcella Rietschel; Kieran C Murphy; Michael C O'Donovan; Markus M Nöthen; Michael J Owen
No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples.
Biological psychiatry 2005;58(1):78-80.
2005: Darko Turic; Kate Langley; Hywel Williams; Nadine Norton; Nigel M Williams; Valentina Moskvina; Marianne B M van den Bree; Michael J Owen; Anita Thapar; Michael C O'Donovan
A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder.
Biological psychiatry 2005;57(11):1461-6.
2005: Elaine K Green; Rachel Raybould; Stuart Macgregor; Katherine Gordon-Smith; Jessica Heron; Sally Hyde; Detelina Grozeva; Marian Hamshere; Nigel Williams; Michael J Owen; Michael C O'Donovan; Lisa Jones; Ian Jones; George Kirov; Nick Craddock
Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder.
Archives of general psychiatry 2005;62(6):642-8.
2005: George Kirov; Michael C O'Donovan; Michael J Owen
Finding schizophrenia genes.
The Journal of clinical investigation 2005;115(6):1440-8.
2005: Rachel Raybould; Elaine K Green; Stuart Macgregor; Katherine Gordon-Smith; Jessica Heron; Sally Hyde; Sian Caesar; Ivan Nikolov; Nigel Williams; Lisa Jones; Michael C O'Donovan; Michael J Owen; Ian Jones; George Kirov; Nick Craddock
Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1).
Biological psychiatry 2005;57(7):696-701.
2005: Natalie Cope; Denise Harold; Gary Hill; Valentina Moskvina; Jim Stevenson; Peter Holmans; Michael J Owen; Michael C O'Donovan; Julie Williams
Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia.
American journal of human genetics 2005;76(4):581-91.
2005: Nick Craddock; Michael C O'Donovan; Michael J Owen
The genetics of schizophrenia and bipolar disorder: dissecting psychosis.
Journal of medical genetics 2005;42(3):193-204.
2005: Paul R Buckland; Bastiaan Hoogendoorn; Carol A Guy; S Kaye Smith; Sharon L Coleman; Michael C O'Donovan
Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain.
The American journal of psychiatry 2005;162(3):613-5.
2005: Natalie Cope; Gary Hill; Marianne B M van den Bree; Denise Harold; Valentina Moskvina; E K Green; Michael J Owen; Julie Williams; Michael C O'Donovan
No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia.
Molecular psychiatry 2005;10(3):237-8.
2005: Darko Turic; Hywel Williams; Kate Langley; Michael J Owen; Anita Thapar; Michael C O'Donovan
A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;133B(1):64-7.
2005: Nadine Norton; Hywel J Williams; Sarah Dwyer; Dobril Ivanov; Anna Preece; Amy Gerrish; Nigel M Williams; Pamela Yerassimou; Stanley Zammit; Michael C O'Donovan; Michael J Owen
No evidence for association between polymorphisms in GRM3 and schizophrenia.
BMC psychiatry 2005;5():23.
2005: Elaine Green; Gareth P Elvidge; Nick Jacobsen; Beate Glaser; Ian Jones; Michael C O'Donovan; George Kirov; Michael J Owen; Nick Craddock
Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease.
The American journal of psychiatry 2005;162(1):35-42.
2004: Nicholas J Bray; Luke Jehu; Valentina Moskvina; Joseph Buxbaum; Stella Dracheva; Vahram Haroutunian; Julie Williams; Paul R Buckland; Michael J Owen; Michael C O'Donovan
Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes.
Human molecular genetics 2004;13(22):2885-92.
2004: Paul R Buckland; Bastiaan Hoogendoorn; Carol A Guy; Sharon L Coleman; S Kaye Smith; Joseph Buxbaum; Vahram Haroutunian; Michael C O'Donovan
A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity.
Biochimica et biophysica acta 2004;1690(3):238-49.
2004: Derek W Morris; D Ivanov; L Robinson; Nigel Williams; J Stevenson; Michael J Owen; Julie Williams; Michael C O'Donovan
Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;129B(1):97-103.
2004: Bastiaan Hoogendoorn; Sharon L Coleman; Carol A Guy; S Kaye Smith; Michael C O'Donovan; Paul R Buckland
Functional analysis of polymorphisms in the promoter regions of genes on 22q11.
Human mutation 2004;24(1):35-42.
2004: Stanley Zammit; Gaynor Jones; Susan J Jones; Nadine Norton; Robert D Sanders; Charis Milham; Geraldine M McCarthy; Lisa Anne Jones; Alastair G Cardno; Marion Gray; Kieran C Murphy; Michael C O'Donovan; Michael J Owen
Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;128B(1):19-20.
2004: George Kirov; Dobril Ivanov; Nigel M Williams; Anna Preece; Ivan Nikolov; Radoi Milev; Svetlinka Koleva; Albena Dimitrova; Draga Toncheva; Michael C O'Donovan; Michael J Owen
Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria.
Biological psychiatry 2004;55(10):971-5.
2004: Darko Turic; Kate Langley; George Kirov; Michael J Owen; Anita Thapar; Michael C O'Donovan
Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;127B(1):68-72.
2004: Michael J Owen; Nigel M Williams; Michael C O'Donovan
Dysbindin-1 and schizophrenia: from genetics to neuropathology.
The Journal of clinical investigation 2004;113(9):1255-7.
2004: Nigel M Williams; Anna Preece; Derek W Morris; Gillian Spurlock; Nicholas J Bray; M Stephens; Nadine Norton; Hywel Williams; M Clement; Sarah Dwyer; C Curran; J Wilkinson; Valentina Moskvina; John L Waddington; Michael Gill; Aiden Corvin; Stanley Zammit; George Kirov; Michael J Owen; Michael C O'Donovan
Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1).
Archives of general psychiatry 2004;61(4):336-44.
2004: Nigel M Williams; Anna Preece; Gillian Spurlock; Nadine Norton; Hywel J Williams; Robin G McCreadie; Paul R Buckland; Val Sharkey; Kodavali V Chowdari; Stanley Zammit; Vishwajit L Nimgaonkar; George Kirov; Michael J Owen; Michael C O'Donovan
Support for RGS4 as a susceptibility gene for schizophrenia.
Biological psychiatry 2004;55(2):192-5.
2004: Paul R Buckland; Sharon L Coleman; Bastiaan Hoogendoorn; Carol Guy; S Kaye Smith; Michael C O'Donovan
A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity.
Gene expression 2004;11(5-6):233-9.
2004: Sophie Mills; Kate Langley; Marianne B M van den Bree; Eddy Street; Darko Turic; Michael J Owen; Michael C O'Donovan; Anita Thapar
No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study.
BMC psychiatry 2004;4():15.
2004: Carol A Guy; Bastiaan Hoogendoorn; S Kaye Smith; Sharon Coleman; Michael C O'Donovan; Paul R Buckland
Promoter polymorphisms in glutathione-S-transferase genes affect transcription.
Pharmacogenetics 2004;14(1):45-51.
2004: Nadine Norton; Nigel M Williams; Michael C O'Donovan; Michael J Owen
DNA pooling as a tool for large-scale association studies in complex traits.
Annals of medicine 2004;36(2):146-52.
2004: Nicholas J Bray; Paul R Buckland; Håkan Hall; Michael J Owen; Michael C O'Donovan
The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain.
Molecular psychiatry 2004;9(1):109-14.
2004: Michael J Owen; Nigel M Williams; Michael C O'Donovan
The molecular genetics of schizophrenia: new findings promise new insights.
Molecular psychiatry 2004;9(1):14-27.
2003: S Kaye Smith; Bastiaan Hoogendoorn; Carol A Guy; Sharon L Coleman; Michael C O'Donovan; Paul R Buckland
Lack of functional promoter polymorphisms in genes involved in glutamate neurotransmission.
Psychiatric genetics 2003;13(4):193-9.
2003: Nigel M Williams; Nadine Norton; Hywel Williams; Birgit Ekholm; Marian Hamshere; Y Lindblom; Kodavali V Chowdari; Alastair G Cardno; Stanley Zammit; Lisa Anne Jones; Kieran C Murphy; Robert D Sanders; G McCarthy; MY Gray; G Jones; Peter Holmans; Vishwajit L Nimgaonkar; R Adolfson; Urban Osby; L Terenius; Göran C Sedvall; Michael C O'Donovan; Michael J Owen
A systematic genomewide linkage study in 353 sib pairs with schizophrenia.
American journal of human genetics 2003;73(6):1355-67.
2003: Dobril Ivanov; George Kirov; Nadine Norton; Hywel J Williams; Nigel M Williams; Ivan Nikolov; R Tzwetkova; S M Stambolova; Kieran C Murphy; Draga Toncheva; Anita Thapar; Michael C O'Donovan; Michael J Owen
Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis. Molecular genetic study.
The British journal of psychiatry : the journal of mental science 2003;183():409-13.
2003: Michael C O'Donovan; Nigel M Williams; Michael J Owen
Recent advances in the genetics of schizophrenia.
Human molecular genetics 2003;12 Spec No 2():R125-33.
2003: Bastiaan Hoogendoorn; Sharon L Coleman; Carol A Guy; Kaye Smith; Timothy Bowen; Paul R Buckland; Michael C O'Donovan
Functional analysis of human promoter polymorphisms.
Human molecular genetics 2003;12(18):2249-54.
2003: Antony Payton; Darko Turic; Kate Langley; Sophie Mills; Deborah C Lawson; Marianne B M van den Bree; Michael J Owen; Michael C O'Donovan; W E R Ollier; Jane Worthington; Anita Thapar
No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.
Psychiatric genetics 2003;13(3):183-5.
2003: Hywel J Williams; Nigel Williams; Gillian Spurlock; Nadine Norton; Dobril Ivanov; Robin G McCreadie; Anna Preece; Val Sharkey; Sue Jones; Stanley Zammit; Ivan Nikolov; I Kehaiov; Anita Thapar; Kieran C Murphy; George Kirov; Michael J Owen; Michael C O'Donovan
Association between PRODH and schizophrenia is not confirmed.
Molecular psychiatry 2003;8(7):644-5.
2003: Hywel J Williams; Nigel Williams; Gillian Spurlock; Nadine Norton; Stanley Zammit; George Kirov; Michael J Owen; Michael C O'Donovan
Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003;120B(1):42-6.
2003: Nadine Norton; Hywel J Williams; Nigel M Williams; Gillian Spurlock; Stanley Zammit; Gaynor Jones; Sue Jones; Richard Owen; Michael C O'Donovan; Michael J Owen
Mutation screening of the Homer gene family and association analysis in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003;120B(1):18-21.
2003: Nicholas J Bray; Paul R Buckland; Nigel M Williams; Hywel J Williams; Nadine Norton; Michael J Owen; Michael C O'Donovan
A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.
American journal of human genetics 2003;73(1):152-61.
2003: Nicholas J Bray; Paul R Buckland; Michael J Owen; Michael C O'Donovan
Cis-acting variation in the expression of a high proportion of genes in human brain.
Human genetics 2003;113(2):149-53.
2003: Kate Langley; Antony Payton; Marian Hamshere; Helen M Pay; Deborah C Lawson; Darko Turic; W E R Ollier; Jane Worthington; Michael J Owen; Michael C O'Donovan; Anita Thapar
No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder.
Psychiatric genetics 2003;13(2):107-10.
2003: Nigel M Williams; Anna Preece; Gillian Spurlock; Nadine Norton; Hywel J Williams; Stanley Zammit; Michael C O'Donovan; Michael J Owen
Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia.
Molecular psychiatry 2003;8(5):485-7.
2003: Darko Turic; L Robinson; M Duke; Derek W Morris; V Webb; Marian Hamshere; Charis Milham; Elizabeth Hopkin; K Pound; S Fernando; A Grierson; M Easton; Nigel Williams; Marianne B M van den Bree; R Chowdhury; J Gruen; J Stevenson; Michael Krawczak; Michael J Owen; Michael C O'Donovan; Julie Williams
Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22.
Molecular psychiatry 2003;8(2):176-85.
2003: Deborah C Lawson; Darko Turic; Kate Langley; Helen M Pay; Catherine F Govan; Nadine Norton; Marian Hamshere; Michael J Owen; Michael C O'Donovan; Anita Thapar
Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003;116B(1):84-9.
2002: Nicholas J Bray; George Kirov; R J Owen; NJ Jacobsen; Lyudmila Georgieva; Hywel J Williams; Nadine Norton; Gillian Spurlock; Sue Jones; Stanley Zammit; Michael C O'Donovan; Michael J Owen
Screening the human protocadherin 8 (PCDH8) gene in schizophrenia.
Genes, brain, and behavior 2002;1(3):187-91.
2002: Sharon L Coleman; Bastiaan Hoogendoorn; Carol Guy; S Kaye Smith; Michael C O'Donovan; Paul R Buckland
Streamlined approach to functional analysis of promoter-region polymorphisms.
BioTechniques 2002;33(2):412, 414, 416 passim.
2002: Sharon L Coleman; Paul R Buckland; Bastiaan Hoogendoorn; Carol Guy; Kaye Smith; Michael C O'Donovan
Experimental analysis of the annotation of promoters in the public database.
Human molecular genetics 2002;11(16):1817-21.
2002: Nadine Norton; George Kirov; Stanley Zammit; Gaynor Jones; Susan Jones; Richard Owen; Michael Krawczak; Nigel M Williams; Michael C O'Donovan; Michael J Owen
Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasis.
American journal of medical genetics 2002;114(5):491-6.
2002: Nadine Norton; Nigel M Williams; Hywel J Williams; Gillian Spurlock; George Kirov; Derek W Morris; Bastiaan Hoogendoorn; Michael J Owen; Michael C O'Donovan
Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools.
Human genetics 2002;110(5):471-8.
2002: Nigel M Williams; Gillian Spurlock; Nadine Norton; Hywel J Williams; Marian Hamshere; Michael Krawczak; George Kirov; Ivan Nikolov; Lyudmila Georgieva; Sue Jones; Alastair G Cardno; Michael C O'Donovan; Michael J Owen
Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach.
Molecular psychiatry 2002;7(10):1092-100.
2002: Nigel M Williams; Timothy Bowen; Gillian Spurlock; Nadine Norton; Hywel J Williams; Bastiaan Hoogendoorn; Michael J Owen; Michael C O'Donovan
Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.
Molecular psychiatry 2002;7(5):508-14.
2002: R J Anney; Mark I Rees; E Bryan; Gillian Spurlock; Nigel Williams; Nadine Norton; Hywel Williams; Alastair G Cardno; Stanley Zammit; Sue Jones; G Jones; Bastiaan Hoogendoorn; Kaye Smith; Marian Hamshere; S Coleman; Carol Guy; Michael C O'Donovan; Michael J Owen; Paul R Buckland
Characterisation, mutation detection, and association analysis of alternative promoters and 5' UTRs of the human dopamine D3 receptor gene in schizophrenia.
Molecular psychiatry 2002;7(5):493-502.
2002: Nigel M Williams; Michael C O'Donovan; Michael J Owen
Genome scans and microarrays: converging on genes for schizophrenia?
Genome biology 2002;3(4):REVIEWS1011.
2001: George Kirov; C A Lowry; M Stephens; S Oldfield; Michael C O'Donovan; S L Lightman; Michael J Owen
Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder.
Molecular psychiatry 2001;6(6):671-7.
2001: Alastair G Cardno; Peter Holmans; Mark I Rees; Lisa Anne Jones; Geraldine M McCarthy; Marian Hamshere; Nigel M Williams; Nadine Norton; Hywel J Williams; Iain Fenton; Kieran C Murphy; Robert D Sanders; MY Gray; Michael C O'Donovan; Peter McGuffin; Michael J Owen
A genomewide linkage study of age at onset in schizophrenia.
American journal of medical genetics 2001;105(5):439-45.
2001: Timothy Bowen; N Williams; Nadine Norton; Gillian Spurlock; Oliver H Wittekindt; Deborah J Morris-Rosendahl; Hywel Williams; L Brzustowicz; Bastiaan Hoogendoorn; Stanley Zammit; G Jones; Robert D Sanders; Lisa Anne Jones; G McCarthy; S Jones; A Bassett; Alastair G Cardno; Michael J Owen; Michael C O'Donovan
Mutation screening of the KCNN3 gene reveals a rare frameshift mutation.
Molecular psychiatry 2001;6(3):259-60.
2001: NJ Jacobsen; Gareth P Elvidge; EK Franks; Michael C O'Donovan; Nick Craddock; Michael J Owen
CUX2, a potential regulator of NCAM expression: genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder.
American journal of medical genetics 2001;105(3):295-300.
2001: NJ Jacobsen; EK Franks; Gareth P Elvidge; Ian Jones; Fiona McCandless; Michael C O'Donovan; Michael J Owen; Nick Craddock
Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder.
Molecular psychiatry 2001;6(1):92-7.
2000: John B Vincent; Qiu-Ping Yuan; Martin Schalling; Rolf Adolfsson; Maria H Azevedo; antonio macedo; A Bauer; C DallaTorre; Helena Medeiros; Michele T Pato; Carlos N Pato; Timothy Bowen; Carol A Guy; Michael J Owen; Michael C O'Donovan; Andrew D Paterson; Arturas Petronis; James L Kennedy
Long repeat tracts at SCA8 in major psychosis.
American journal of medical genetics 2000;96(6):873-6.
2000: Timothy Bowen; L Ashworth; George Kirov; Carol A Guy; Ian Richard Jones; Fiona McCandless; Nick Craddock; Michael C O'Donovan; Michael J Owen
No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder.
Bipolar disorders 2000;2(4):328-31.
2000: Bastiaan Hoogendoorn; Nadine Norton; George Kirov; Nigel Williams; Marian Hamshere; Gillian Spurlock; J Austin; M K Stephens; Paul R Buckland; Michael J Owen; Michael C O'Donovan
Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools.
Human genetics 2000;107(5):488-93.
2000: J Austin; Paul R Buckland; Alastair G Cardno; Nigel Williams; Gillian Spurlock; Bastiaan Hoogendoorn; Stanley Zammit; G Jones; R Sanders; Lesley Jones; G McCarthy; Sue Jones; Nicholas J Bray; Peter McGuffin; Michael J Owen; Michael C O'Donovan
The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia.
Molecular psychiatry 2000;5(5):552-7.
2000: G Speight; Darko Turic; J Austin; Bastiaan Hoogendoorn; Alastair G Cardno; Lesley Jones; Kieran C Murphy; R Sanders; G McCarthy; Ian Jones; Fiona McCandless; Peter McGuffin; Nick Craddock; Michael J Owen; Paul R Buckland; Michael C O'Donovan
Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder.
Molecular psychiatry 2000;5(3):327-31.
2000: Derek W Morris; L Robinson; Darko Turic; M Duke; V Webb; Charis Milham; Elizabeth Hopkin; K Pound; S Fernando; M Easton; Marian Hamshere; Nigel Williams; Peter McGuffin; J Stevenson; Michael Krawczak; Michael J Owen; Michael C O'Donovan; Julie Williams
Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q.
Human molecular genetics 2000;9(5):843-8.
2000: J Austin; Bastiaan Hoogendoorn; Paul R Buckland; Ian Jones; Fiona McCandless; Nigel Williams; Fiona Middle; Michael J Owen; Nick Craddock; Michael C O'Donovan
Association analysis of the proneurotensin gene and bipolar disorder.
Psychiatric genetics 2000;10(1):51-4.
2000: Timothy Bowen; Carol A Guy; Alastair G Cardno; John B Vincent; James L Kennedy; Lisa Anne Jones; Marion Gray; Robert D Sanders; G McCarthy; Kieran C Murphy; Michael J Owen; Michael C O'Donovan
Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia.
Psychiatric genetics 2000;10(1):33-7.
2000: J Austin; Bastiaan Hoogendoorn; Paul R Buckland; G Speight; Alastair G Cardno; Timothy Bowen; Nigel Williams; Gillian Spurlock; R Sanders; Lesley Jones; K Murphy; G McCarthy; Peter McGuffin; Michael J Owen; Michael C O'Donovan
Comparative sequencing of the proneurotensin gene and association studies in schizophrenia.
Molecular psychiatry 2000;5(2):208-12.
2000: Michael J Owen; Alastair G Cardno; Michael C O'Donovan
Psychiatric genetics: back to the future.
Molecular psychiatry 2000;5(1):22-31.
1999: Michael C O'Donovan; Michael J Owen
Candidate-gene association studies of schizophrenia.
American journal of human genetics 1999;65(3):587-92.
1999: NJ Jacobsen; Ita Lyons; Bastiaan Hoogendoorn; S Burge; P Y Kwok; Michael C O'Donovan; Nick Craddock; Michael J Owen
ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes.
Human molecular genetics 1999;8(9):1631-6.
1999: Carol A Guy; Timothy Bowen; Ian Jones; Fiona McCandless; Michael J Owen; Nick Craddock; Michael C O'Donovan
CTG18.1 and ERDA-1 CAG/CTG repeat size in bipolar disorder.
Neurobiology of disease 1999;6(4):302-7.
1999: AC Jones; J Austin; N Hansen; Bastiaan Hoogendoorn; PJ Oefner; Jeremy P Cheadle; Michael C O'Donovan
Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis.
Clinical chemistry 1999;45(8 Pt 1):1133-40.
1999: Alastair G Cardno; Timothy Bowen; Carol A Guy; Lisa Anne Jones; G McCarthy; Nigel M Williams; Kieran C Murphy; Gillian Spurlock; Marion Gray; Robert D Sanders; Nick Craddock; Peter McGuffin; Michael J Owen; Michael C O'Donovan
CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia.
Biological psychiatry 1999;45(12):1592-6.
1999: EK Franks; Carol Guy; N Jacobsen; Timothy Bowen; Michael J Owen; Michael C O'Donovan; Nick Craddock
Eleven trinucleotide repeat loci that map to chromosome 12 excluded from involvement in the pathogenesis of bipolar disorder.
American journal of medical genetics 1999;88(1):67-70.
1999: Carol A Guy; Timothy Bowen; Nigel Williams; Ian Richard Jones; Fiona McCandless; Peter McGuffin; Michael J Owen; Nick Craddock; Michael C O'Donovan
No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder.
American journal of medical genetics 1999;88(1):57-60.
1999: Bastiaan Hoogendoorn; Michael J Owen; PJ Oefner; Nigel Williams; J Austin; Michael C O'Donovan
Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography.
Human genetics 1999;104(1):89-93.
1998: Michael C O'Donovan; PJ Oefner; S C Roberts; J Austin; Bastiaan Hoogendoorn; Carol Guy; G Speight; Meena Upadhyaya; S S Sommer; Peter McGuffin
Blind analysis of denaturing high-performance liquid chromatography as a tool for mutation detection.
Genomics 1998;52(1):44-9.
1998: Timothy Bowen; Carol A Guy; Nick Craddock; Alastair G Cardno; Nigel M Williams; Gillian Spurlock; Kieran C Murphy; Lisa Anne Jones; Marion Gray; Robert D Sanders; G McCarthy; K George Chandy; Emmanuelle Fantino; Katalin Kalman; George A Gutman; J Jay Gargus; Julie Williams; Peter McGuffin; Michael J Owen; Michael C O'Donovan
Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia.
Molecular psychiatry 1998;3(3):266-9.
1998: Alastair G Cardno; Fiona McCandless; Timothy Bowen; Carol A Guy; Lisa Anne Jones; Kieran C Murphy; Peter McGuffin; Michael J Owen; Nick Craddock; Michael C O'Donovan
Association between functional psychosis and expanded CAG/CTG repeats is not explained by health stratification.
Psychiatric genetics 1998;8(1):29-32.
1998: Timothy Bowen; Nadine Norton; NJ Jacobsen; Carol Guy; johanna k macpherson; Robert D Sanders; Alastair G Cardno; Lisa Anne Jones; Kieran C Murphy; Peter McGuffin; Nick Craddock; Michael C O'Donovan; Michael J Owen
Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder.
Molecular psychiatry 1998;3(1):67-71.
1997: Nick Craddock; Patrick McKeon; S Moorhead; Carol Guy; D Harrison; Lesley Mynett-Johnson; E Claffey; E Feldman; Peter McGuffin; Michael J Owen; Michael C O'Donovan
Expanded CAG/CTG repeats in bipolar disorder: no correlation with phenotypic measures of illness severity.
Biological psychiatry 1997;42(10):876-81.
1997: AL Jones; Fiona Middle; Carol Guy; Gillian Spurlock; Nigel J Cairns; Peter McGuffin; Nick Craddock; Michael J Owen; Michael C O'Donovan
No evidence for expanded polyglutamine sequences in bipolar disorder and schizophrenia.
Molecular psychiatry 1997;2(6):478-82.
1997: Carol Guy; Timothy Bowen; johanna k macpherson; G Speight; Patrick McKeon; Lesley Mynett-Johnson; E Claffey; Peter McGuffin; Michael J Owen; Nick Craddock; Michael C O'Donovan
Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder.
The American journal of psychiatry 1997;154(8):1146-7.
1997: G Speight; Carol Guy; Timothy Bowen; Philip Asherson; Peter McGuffin; Nick Craddock; Michael J Owen; Michael C O'Donovan
Exclusion of CAG/CTG trinucleotide repeat loci which map to chromosome 4 in bipolar disorder and schizophrenia.
American journal of medical genetics 1997;74(2):204-6.
1997: Michael C O'Donovan; Carol Guy
Bias in the genomic distribution of CAG and CTG trinucleotide repeats.
American journal of medical genetics 1997;74(1):62-4.
1996: Nick Craddock; Michael C O'Donovan; Michael J Owen
Introducing Selfcite 2.0--career enhancing software.
BMJ (Clinical research ed.) 1996;313(7072):1659-60.
1996: Michael C O'Donovan; Nick Craddock; Carol Guy; Peter McGuffin; Michael J Owen
Involvement of expanded trinucleotide repeats in common diseases.
Lancet 1996;348(9043):1739-40.
1996: Michael C O'Donovan; Michael J Owen
The molecular genetics of schizophrenia.
Annals of medicine 1996;28(6):541-6.
1996: Alastair G Cardno; Kieran C Murphy; Lisa Anne Jones; Carol A Guy; Philip Asherson; M H De Azevedo; Isabel Coelho; A J de Macedo e Santos; C N Pato; Peter McGuffin; Michael J Owen; Michael C O'Donovan
Expanded CAG/CTG repeats in schizophrenia. A study of clinical correlates.
The British journal of psychiatry : the journal of mental science 1996;169(6):766-71.
1996: Michael C O'Donovan; Carol Guy; Nick Craddock; Timothy Bowen; Patrick McKeon; antonio macedo; W Maier; D Wildenauer; Harald N Aschauer; Sandro Sorbi; E Feldman; Lesley Mynett-Johnson; E Claffey; Benedetta Nacmias; José Valente; Ana Dourado; E Grassi; Elisabeth Lenzinger; Angela Heiden; S Moorhead; D Harrison; Julie Williams; Peter McGuffin; Michael J Owen
Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder.
Psychological medicine 1996;26(6):1145-53.
1996: Timothy Bowen; Carol Guy; G Speight; L Jones; Alastair G Cardno; K Murphy; Peter McGuffin; Michael J Owen; Michael C O'Donovan
Expansion of 50 CAG/CTG repeats excluded in schizophrenia by application of a highly efficient approach using repeat expansion detection and a PCR screening set.
American journal of human genetics 1996;59(4):912-7.
1995: Michael C O'Donovan; C Guy; N Craddock; Kieran C Murphy; Alastair G Cardno; L A Jones; Michael J Owen; Peter McGuffin
Expanded CAG repeats in schizophrenia and bipolar disorder.
Nature genetics 1995;10(4):380-1.
1994: A Thapar; Irving Gottesman; Michael J Owen; Michael C O'Donovan; Peter McGuffin
The genetics of mental retardation.
The British journal of psychiatry : the journal of mental science 1994;164(6):747-58.
1993: Paul R Buckland; Michael C O'Donovan; Peter McGuffin
Clozapine and sulpiride up-regulate dopamine D3 receptor mRNA levels.
Neuropharmacology 1993;32(9):901-7.
1993: Paul R Buckland; Michael C O'Donovan; Peter McGuffin
Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs.
Neuroscience letters 1993;150(1):25-8.
1992: Paul R Buckland; Michael C O'Donovan; Peter McGuffin
Lack of effect of chronic antipsychotic treatment on dopamine D5 receptor mRNA level.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1992;2(4):405-9.
1992: Michael C O'Donovan; Paul R Buckland; Gillian Spurlock; Peter McGuffin
Bi-directional changes in the levels of messenger RNAs encoding gamma-aminobutyric acidA receptor alpha subunits after flurazepam treatment.
European journal of pharmacology 1992;226(4):335-41.
1992: Michael C O'Donovan; Michael J Owen
Advances and retreats in the molecular genetics of major mental illness.
Annals of medicine 1992;24(3):171-7.
1992: Michael C O'Donovan; Paul R Buckland; Peter McGuffin
Levels of GABAa receptor subunit mRNA in rat brain following flurazepam treatment.
Journal of psychopharmacology (Oxford, England) 1992;6(3):364-9.
1992: Paul R Buckland; Michael C O'Donovan; Peter McGuffin
Changes in dopa decarboxylase mRNA but not tyrosine hydroxylase mRNA levels in rat brain following antipsychotic treatment.
Psychopharmacology 1992;108(1-2):98-102.
1992: Michael C O'Donovan; Paul R Buckland; Peter McGuffin
The expression of neuroreceptor genes and benzodiazepine tolerance.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():218A-219A.
1992: Paul R Buckland; Michael C O'Donovan; Peter McGuffin
Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment.
Psychopharmacology 1992;106(4):479-83.
1991: Michael C O'Donovan; Paul R Buckland; Peter McGuffin
Simultaneous quantification of several mRNA species by solution hybridisation with oligonucleotides.
Nucleic acids research 1991;19(12):3466.
1991: H L Havard; Paul R Buckland; Michael C O'Donovan; Peter McGuffin
The effects of antidepressant drugs on kainate receptor mRNA levels.
Neuropharmacology 1991;30(6):675-7.