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Brian O'Dowd

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Gabriela Novak; Brian F O'Dowd; Theresa Fan; Susan R George
Postnatal maternal deprivation and pubertal stress have additive effects on dopamine D2 receptor and CaMKII beta expression in the striatum.
Gabriela Novak; Brian F O'Dowd; Theresa Fan; Susan R George
Striatal development involves a switch in gene expression networks, followed by a myelination event: implications for neuropsychiatric disease.
Melissa L Perreault; Jace Jones-Tabah; Brian F O'Dowd; Susan R George
A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex.

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All Publications

2013: Gabriela Novak; Brian F O'Dowd; Theresa Fan; Susan R George
Postnatal maternal deprivation and pubertal stress have additive effects on dopamine D2 receptor and CaMKII beta expression in the striatum.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2013;31(3):189-95.
2013: Gabriela Novak; Brian F O'Dowd; Theresa Fan; Susan R George
Striatal development involves a switch in gene expression networks, followed by a myelination event: implications for neuropsychiatric disease.
Synapse (New York, N.Y.) 2013;67(4):179-88.
2013: Melissa L Perreault; Jace Jones-Tabah; Brian F O'Dowd; Susan R George
A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2013;16(2):477-83.
2013: Brian F O'Dowd; Xiaodong Ji; Tuan Nguyen; Susan R George
D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation.
Biochemical and biophysical research communications 2013;431(3):586-9.
2012: Melissa Perreault; Mohammad Alijaniaram; Ahmed Hasbi; Brian F O'Dowd; Susan R George
Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats.
Neuroscience 2012;225():130-9.
2012: Brian F O'Dowd; Paul B O'Dowd; Xiaodong Ji; Tuan Nguyen; Susan R George
Disruption of the mu-delta opioid receptor heteromer.
Biochemical and biophysical research communications 2012;422(4):556-60.
2012: Brian F O'Dowd; Xiaodong Ji; Tuan V Nguyen; Susan R George
Two amino acids in each of D1 and D2 dopamine receptor cytoplasmic regions are involved in D1-D2 heteromer formation.
Biochemical and biophysical research communications 2012;417(1):23-8.
2012: Melissa Perreault; Brian F O'Dowd; Mohammad Alijaniaram; Theresa Fan; Susan R George
Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2.
PloS one 2012;7(3):e33348.
2011: Brian F O'Dowd; Xiaodong Ji; Mohammad Alijaniaram; Tuan V Nguyen; Susan R George
Separation and reformation of cell surface dopamine receptor oligomers visualized in cells.
European journal of pharmacology 2011;658(2-3):74-83.
2011: Michael M C Kong; Vaneeta Verma; Brian F O'Dowd; Susan R George
The role of palmitoylation in directing dopamine D1 receptor internalization through selective endocytic routes.
Biochemical and biophysical research communications 2011;405(3):445-9.
2011: Melissa Perreault; Brian F O'Dowd; Susan R George
Dopamine receptor homooligomers and heterooligomers in schizophrenia.
CNS neuroscience & therapeutics 2011;17(1):52-7.
2011: Melissa Perreault; Ahmed Hasbi; Brian F O'Dowd; Susan R George
The dopamine d1-d2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in Basal Ganglia.
Frontiers in neuroanatomy 2011;5():31.
2011: Ahmed Hasbi; Brian F O'Dowd; Susan R George
Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance.
Molecular brain 2011;4():26.
2010: Melissa Perreault; Ahmed Hasbi; Mohammad Alijaniaram; Theresa Fan; George Varghese; Paul J Fletcher; Philip Seeman; Brian F O'Dowd; Susan R George
The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia.
The Journal of biological chemistry 2010;285(47):36625-34.
2010: Vaneeta Verma; Ahmed Hasbi; Brian F O'Dowd; Susan R George
Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2.
The Journal of biological chemistry 2010;285(45):35092-103.
2010: N Kabli; N Martin; Theresa Fan; Tuan V Nguyen; Ahmed Hasbi; G Balboni; Brian F O'Dowd; Susan R George
Agonists at the δ-opioid receptor modify the binding of µ-receptor agonists to the µ-δ receptor hetero-oligomer.
British journal of pharmacology 2010;161(5):1122-36.
2010: Dennis K Lee; Stephen S G Ferguson; Susan R George; Brian F O'Dowd
The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin.
Biochemical and biophysical research communications 2010;395(2):185-9.
2010: Ahmed Hasbi; Brian F O'Dowd; Susan R George
Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms.
Current opinion in pharmacology 2010;10(1):93-9.
2010: J Ng; Asim J Rashid; Christopher H So; Brian F O'Dowd; Susan R George
Activation of calcium/calmodulin-dependent protein kinase IIalpha in the striatum by the heteromeric D1-D2 dopamine receptor complex.
Neuroscience 2010;165(2):535-41.
2010: Mufida B El-Ghundi; Theresa Fan; Joanna M Karasinska; John Yeung; Millee Zhou; Brian F O'Dowd; Susan R George
Restoration of amphetamine-induced locomotor sensitization in dopamine D1 receptor-deficient mice.
Psychopharmacology 2010;207(4):599-618.
2009: Ahmed Hasbi; Theresa Fan; Mohammad Alijaniaram; Tuan V Nguyen; Melissa Perreault; Brian F O'Dowd; Susan R George
Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(50):21377-82.
2009: Christopher H So; Vaneeta Verma; Mohammad Alijaniaram; Regina Cheng; Asim J Rashid; Brian F O'Dowd; Susan R George
Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers.
Molecular pharmacology 2009;75(4):843-54.
2008: Jason R Juhasz; Ahmed Hasbi; Asim J Rashid; Christopher H So; Susan R George; Brian F O'Dowd
Mu-opioid receptor heterooligomer formation with the dopamine D1 receptor as directly visualized in living cells.
European journal of pharmacology 2008;581(3):235-43.
2007: Ahmed Hasbi; Tuan V Nguyen; Theresa Fan; Regina Cheng; Asim J Rashid; Mohammad Alijaniaram; Mark M Rasenick; Brian F O'Dowd; Susan R George
Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists.
Biochemistry 2007;46(45):12997-3009.
2007: Asim J Rashid; Brian F O'Dowd; Vaneeta Verma; Susan R George
Neuronal Gq/11-coupled dopamine receptors: an uncharted role for dopamine.
Trends in pharmacological sciences 2007;28(11):551-5.
2007: Michael M C Kong; Ahmed Hasbi; Michael Mattocks; Theresa Fan; Brian F O'Dowd; Susan R George
Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1.
Molecular pharmacology 2007;72(5):1157-70.
2007: Christopher H So; Vaneeta Verma; Brian F O'Dowd; Susan R George
Desensitization of the dopamine D1 and D2 receptor hetero-oligomer mediated calcium signal by agonist occupancy of either receptor.
Molecular pharmacology 2007;72(2):450-62.
2007: Brian F O'Dowd; Mohammad Alijaniaram; Xiaodong Ji; Tuan V Nguyen; Richard M Eglen; Susan R George
Using ligand-induced conformational change to screen for compounds targeting G-protein-coupled receptors.
Journal of biomolecular screening 2007;12(2):175-85.
2007: Asim J Rashid; Christopher H So; Michael M C Kong; Teresa Furtak; Mufida El-Ghundi; Regina Cheng; Brian F O'Dowd; Susan R George
D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(2):654-9.
2007: Susan R George; Brian F O'Dowd
A novel dopamine receptor signaling unit in brain: heterooligomers of D1 and D2 dopamine receptors.
TheScientificWorldJournal 2007;7():58-63.
2007: Mufida El-Ghundi; Brian F O'Dowd; Susan R George
Insights into the role of dopamine receptor systems in learning and memory.
Reviews in the neurosciences 2007;18(1):37-66.
2006: Michael M C Kong; Theresa Fan; George Varghese; Brian F O'Dowd; Susan R George
Agonist-induced cell surface trafficking of an intracellularly sequestered D1 dopamine receptor homo-oligomer.
Molecular pharmacology 2006;70(1):78-89.
2006: Dennis K Lee; Susan R George; Brian F O'Dowd
Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity.
Trends in pharmacological sciences 2006;27(4):190-4.
2005: Theresa Fan; George Varghese; Tuan V Nguyen; Roderick Tse; Brian F O'Dowd; Susan R George
A role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers.
The Journal of biological chemistry 2005;280(46):38478-88.
2005: Brian F O'Dowd; Xiaodong Ji; Mohammad Alijaniaram; Ryan D Rajaram; Michael M C Kong; Asim J Rashid; Tuan V Nguyen; Susan R George
Dopamine receptor oligomerization visualized in living cells.
The Journal of biological chemistry 2005;280(44):37225-35.
2005: Joanna M Karasinska; Susan R George; Regina Cheng; Brian F O'Dowd
Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine-induced locomotor activity, reward and CREB phosphorylation.
The European journal of neuroscience 2005;22(7):1741-50.
2005: Christopher H So; George Varghese; Kevin J Curley; Michael M C Kong; Mohammad Alijaniaram; Xiaodong Ji; Tuan V Nguyen; Brian F O'Dowd; Susan R George
D1 and D2 dopamine receptors form heterooligomers and cointernalize after selective activation of either receptor.
Molecular pharmacology 2005;68(3):568-78.
2005: Ahmed Hasbi; Brian F O'Dowd; Susan R George
A G protein-coupled receptor for estrogen: the end of the search?
Molecular interventions 2005;5(3):158-61.
2005: Philip Seeman; David Weinshenker; Rémi Quirion; Lalit K Srivastava; Sanjeev K Bhardwaj; David K Grandy; Richard T Premont; Tatyana D Sotnikova; Patricia Boksa; Mufida El-Ghundi; Brian F O'Dowd; Susan R George; Melissa Perreault; Pekka T Männistö; Siobhan Robinson; Richard D Palmiter; Teresa Tallerico
Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3513-8.
2005: Dennis K Lee; Victor R Saldivia; Tuan V Nguyen; Regina Cheng; Susan R George; Brian F O'Dowd
Modification of the terminal residue of apelin-13 antagonizes its hypotensive action.
Endocrinology 2005;146(1):231-6.
2004: Samuel P Lee; Christopher H So; Asim J Rashid; George Varghese; Regina Cheng; A José Lança; Brian F O'Dowd; Susan R George
Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal.
The Journal of biological chemistry 2004;279(34):35671-8.
2004: Asim J Rashid; Brian F O'Dowd; Susan R George
Minireview: Diversity and complexity of signaling through peptidergic G protein-coupled receptors.
Endocrinology 2004;145(6):2645-52.
2004: Dennis K Lee; A José Lança; Regina Cheng; Tuan V Nguyen; Xiao Dong Ji; Fernand Gobeil; Sylvain Chemtob; Susan R George; Brian F O'Dowd
Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors.
The Journal of biological chemistry 2004;279(9):7901-8.
2003: Dennis K Lee; Susan R George; Brian F O'Dowd
Continued discovery of ligands for G protein-coupled receptors.
Life sciences 2003;74(2-3):293-7.
2003: Samuel P Lee; Brian F O'Dowd; Susan R George
Homo- and hetero-oligomerization of G protein-coupled receptors.
Life sciences 2003;74(2-3):173-80.
2003: William B Vanti; Pierandrea Muglia; Tuan V Nguyen; Regina Cheng; James L Kennedy; Susan R George; Brian F O'Dowd
Discovery of a null mutation in a human trace amine receptor gene.
Genomics 2003;82(5):531-6.
2003: Susan R George; Gordon Y K Ng; Samuel P Lee; Theresa Fan; George Varghese; Chen Wang; Charles M Deber; Philip Seeman; Brian F O'Dowd
Blockade of G protein-coupled receptors and the dopamine transporter by a transmembrane domain peptide: novel strategy for functional inhibition of membrane proteins in vivo.
The Journal of pharmacology and experimental therapeutics 2003;307(2):481-9.
2003: Miles D Thompson; Karin Storm van's Gravesande; Helen Galczenski; W McIntyre Burnham; Katherine A Siminovitch; Noe Zamel; Arthur Slutsky; Jeffrey M Drazen; Susan R George; Jilly F Evans; Brian F O'Dowd
A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha.
Pharmacogenetics 2003;13(10):641-9.
2003: Samuel P Lee; Brian F O'Dowd; Ryan D Rajaram; Tuan V Nguyen; Susan R George
D2 dopamine receptor homodimerization is mediated by multiple sites of interaction, including an intermolecular interaction involving transmembrane domain 4.
Biochemistry 2003;42(37):11023-31.
2003: William B Vanti; Tuan V Nguyen; Regina Cheng; Kevin R Lynch; Susan R George; Brian F O'Dowd
Novel human G-protein-coupled receptors.
Biochemical and biophysical research communications 2003;305(1):67-71.
2003: Joanna M Karasinska; Susan R George; Brian F O'Dowd
Family 1 G protein-coupled receptor function in the CNS. Insights from gene knockout mice.
Brain research. Brain research reviews 2003;41(2-3):125-52.
2003: Mufida El-Ghundi; Brian F O'Dowd; Mary Erclik; Susan R George
Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice.
The European journal of neuroscience 2003;17(4):851-62.
2002: Susan R George; Brian F O'Dowd; Samuel P Lee
G-protein-coupled receptor oligomerization and its potential for drug discovery.
Nature reviews. Drug discovery 2002;1(10):808-20.
2002: Dennis K Lee; Susan R George; Brian F O'Dowd
Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets.
Expert opinion on therapeutic targets 2002;6(2):185-202.
2002: Michael Lamey; Miles Thompson; George Varghese; Hong Chi; Marek Sawzdargo; Susan R George; Brian F O'Dowd
Distinct residues in the carboxyl tail mediate agonist-induced desensitization and internalization of the human dopamine D1 receptor.
The Journal of biological chemistry 2002;277(11):9415-21.
2002: Brandon A R Levac; Brian F O'Dowd; Susan R George
Oligomerization of opioid receptors: generation of novel signaling units.
Current opinion in pharmacology 2002;2(1):76-81.
2001: Dennis K Lee; Tuan V Nguyen; Kevin R Lynch; Regina Cheng; William B Vanti; O Arkhitko; T Lewis; Jilly F Evans; Susan R George; Brian F O'Dowd
Discovery and mapping of ten novel G protein-coupled receptor genes.
Gene 2001;275(1):83-91.
2001: Michelle K Clements; Terrence P McDonald; Ruiping Wang; G Xie; Brian F O'Dowd; Susan R George; Christopher P Austin; Qingyun Liu
FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54.
Biochemical and biophysical research communications 2001;284(5):1189-93.
2001: Tuan V Nguyen; D A Shapiro; Susan R George; Vincent Setola; D K Lee; R Cheng; L Rauser; S P Lee; K R Lynch; Bryan L Roth; Brian F O'Dowd
Discovery of a novel member of the histamine receptor family.
Molecular pharmacology 2001;59(3):427-33.
2001: Mufida El-Ghundi; Brian F O'Dowd; Susan R George
Prolonged fear responses in mice lacking dopamine D1 receptor.
Brain research 2001;892(1):86-93.
2001: DK Lee; Susan R George; Jilly F Evans; Kevin R Lynch; Brian F O'Dowd
Orphan G protein-coupled receptors in the CNS.
Current opinion in pharmacology 2001;1(1):31-9.
2001: DK Lee; Susan R George; Regina Cheng; Tuan V Nguyen; Y Liu; M Brown; Kevin R Lynch; Brian F O'Dowd
Identification of four novel human G protein-coupled receptors expressed in the brain.
Brain research. Molecular brain research 2001;86(1-2):13-22.
2000: Miles D Thompson; Nancy Gonzalez; T Nguyen; David E Comings; Susan R George; Brian F O'Dowd
Serotonin transporter gene polymorphisms in alcohol dependence.
Alcohol (Fayetteville, N.Y.) 2000;22(2):61-7.
2000: Samuel P Lee; Z Xie; George Varghese; Tuan V Nguyen; Brian F O'Dowd; Susan R George
Oligomerization of dopamine and serotonin receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;23(4 Suppl):S32-40.
2000: CE Heise; Brian F O'Dowd; David Figueroa; Nicole Sawyer; Tuan V Nguyen; DS Im; Rino Stocco; J N Bellefeuille; Mark Abramovitz; Regina Cheng; David L Williams; Zhizhen Zeng; Qingyun Liu; L Ma; Michelle K Clements; N Coulombe; Yunhao Liu; Christopher P Austin; Susan R George; Gary P O'Neill; Kathleen M Metters; Kevin R Lynch; Jilly F Evans
Characterization of the human cysteinyl leukotriene 2 receptor.
The Journal of biological chemistry 2000;275(39):30531-6.
2000: Susan R George; Theresa Fan; Z Xie; R Tse; V Tam; George Varghese; Brian F O'Dowd
Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties.
The Journal of biological chemistry 2000;275(34):26128-35.
2000: J L Elmhurst; Z Xie; Brian F O'Dowd; Susan R George
The splice variant D3nf reduces ligand binding to the D3 dopamine receptor: evidence for heterooligomerization.
Brain research. Molecular brain research 2000;80(1):63-74.
2000: Joanna M Karasinska; Susan R George; Mufida El-Ghundi; Paul Fletcher; Brian F O'Dowd
Modification of dopamine D(1) receptor knockout phenotype in mice lacking both dopamine D(1) and D(3) receptors.
European journal of pharmacology 2000;399(2-3):171-81.
2000: Samuel P Lee; Brian F O'Dowd; Gordon Y K Ng; George Varghese; Huda Akil; A Mansour; Tuan V Nguyen; Susan R George
Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell.
Molecular pharmacology 2000;58(1):120-8.
2000: DS Im; CE Heise; nicolas ancellin; Brian F O'Dowd; Gan-Ju Shei; Robert P Heavens; MR Rigby; T Hla; Suzanne Mandala; George McAllister; Susan R George; Kevin R Lynch
Characterization of a novel sphingosine 1-phosphate receptor, Edg-8.
The Journal of biological chemistry 2000;275(19):14281-6.
2000: David J Vandenbergh; Miles D Thompson; Edwin H Cook; E Bendahhou; T Nguyen; M D Krasowski; D Zarrabian; David E Comings; E M Sellers; R F Tyndale; Susan R George; Brian F O'Dowd; George R. Uhl
Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations.
Molecular psychiatry 2000;5(3):283-92.
2000: DS Im; CE Heise; Michael A Harding; Susan R George; Brian F O'Dowd; Dan Theodorescu; Kevin R Lynch
Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate.
Molecular pharmacology 2000;57(4):753-9.
2000: Dennis K Lee; Kevin R Lynch; Tuan V Nguyen; D S Im; Regina Cheng; Victor R Saldivia; Ying Liu; IS Liu; Hong-Qiang Heng; Philip Seeman; Susan R George; Brian F O'Dowd; A Marchese
Cloning and characterization of additional members of the G protein-coupled receptor family.
Biochimica et biophysica acta 2000;1490(3):311-23.
2000: D K Lee; R Cheng; Tuan V Nguyen; T Fan; A P Kariyawasam; Y Liu; D H Osmond; Susan R George; Brian F O'Dowd
Characterization of apelin, the ligand for the APJ receptor.
Journal of neurochemistry 2000;74(1):34-41.
1999: H Jin; Z Xie; Susan R George; Brian F O'Dowd
Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor.
European journal of pharmacology 1999;386(2-3):305-12.
1999: Mufida El-Ghundi; Paul Fletcher; John Drago; David R Sibley; Brian F O'Dowd; Susan R George
Spatial learning deficit in dopamine D(1) receptor knockout mice.
European journal of pharmacology 1999;383(2):95-106.
1999: Y Pak; Brian F O'Dowd; Jia Bei Wang; Susan R George
Agonist-induced, G protein-dependent and -independent down-regulation of the mu opioid receptor. The receptor is a direct substrate for protein-tyrosine kinase.
The Journal of biological chemistry 1999;274(39):27610-6.
1999: A Marchese; Susan R George; LF Kolakowski; Kevin R Lynch; Brian F O'Dowd
Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology.
Trends in pharmacological sciences 1999;20(9):370-5.
1999: Z Xie; Samuel P Lee; Brian F O'Dowd; Susan R George
Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed.
FEBS letters 1999;456(1):63-7.
1999: DK Lee; Tuan V Nguyen; C A Porter; Regina Cheng; Susan R George; Brian F O'Dowd
Two related G protein-coupled receptors: the distribution of GPR7 in rat brain and the absence of GPR8 in rodents.
Brain research. Molecular brain research 1999;71(1):96-103.
1999: DK Lee; Tuan V Nguyen; Gary P O'Neill; Regina Cheng; Ying Liu; Andrew D Howard; N Coulombe; Carina P Tan; A T Tang-Nguyen; Susan R George; Brian F O'Dowd
Discovery of a receptor related to the galanin receptors.
FEBS letters 1999;446(1):103-7.
1999: A Marchese; Marek Sawzdargo; Tuan V Nguyen; Regina Cheng; Hong-Qiang Heng; T Nowak; D S Im; Kevin R Lynch; Susan R George; Brian F O'Dowd
Discovery of three novel orphan G-protein-coupled receptors.
Genomics 1999;56(1):12-21.
1999: Marek Sawzdargo; Tuan V Nguyen; DK Lee; Kevin R Lynch; Regina Cheng; Hong-Qiang Heng; Susan R George; Brian F O'Dowd
Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain.
Brain research. Molecular brain research 1999;64(2):193-8.
1998: P Zawarynski; Teresa Tallerico; Philip Seeman; Samuel P Lee; Brian F O'Dowd; Susan R George
Dopamine D2 receptor dimers in human and rat brain.
FEBS letters 1998;441(3):383-6.
1998: LF Kolakowski; Gary P O'Neill; Andrew D Howard; SR Broussard; KA Sullivan; Scott Feighner; Marek Sawzdargo; Tuan V Nguyen; Stacia Kargman; LL Shiao; Donna L Hreniuk; Carina P Tan; J Evans; Mark Abramovitz; Anne Chateauneuf; N Coulombe; G Ng; M P Johnson; A Tharian; Habibeh Khoshbouei; Susan R George; Roy G Smith; Brian F O'Dowd
Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.
Journal of neurochemistry 1998;71(6):2239-51.
1998: Susan R George; Samuel P Lee; George Varghese; P R Zeman; Philip Seeman; Gordon Y K Ng; Brian F O'Dowd
A transmembrane domain-derived peptide inhibits D1 dopamine receptor function without affecting receptor oligomerization.
The Journal of biological chemistry 1998;273(46):30244-8.
1998: Mufida El-Ghundi; Susan R George; John Drago; Paul Fletcher; Theresa Fan; Tuan V Nguyen; C Liu; David R Sibley; H Westphal; Brian F O'Dowd
Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior.
European journal of pharmacology 1998;353(2-3):149-58.
1998: A Marchese; Tuan V Nguyen; P Malik; S Xu; Regina Cheng; Z Xie; Hong-Qiang Heng; Susan R George; LF Kolakowski; Brian F O'Dowd
Cloning genes encoding receptors related to chemoattractant receptors.
Genomics 1998;50(2):281-6.
1998: M Thompson; David E Comings; L Feder; Susan R George; Brian F O'Dowd
Mutation screening of the dopamine D1 receptor gene in Tourette's syndrome and alcohol dependent patients.
American journal of medical genetics 1998;81(3):241-4.
1998: H Jin; S Nip; Brian F O'Dowd; Susan R George
D1 dopamine receptor activity is not altered by a mutation in the first intracellular loop.
Biochimica et biophysica acta 1998;1402(2):165-70.
1998: Brian F O'Dowd; Tuan V Nguyen; A Marchese; Regina Cheng; Kevin R Lynch; Hong-Qiang Heng; LF Kolakowski; Susan R George
Discovery of three novel G-protein-coupled receptor genes.
Genomics 1998;47(2):310-3.
1997: Marek Sawzdargo; Susan R George; Tuan V Nguyen; S Xu; LF Kolakowski; Brian F O'Dowd
A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.
Biochemical and biophysical research communications 1997;239(2):543-7.
1997: Y Pak; Brian F O'Dowd; Susan R George
Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail.
The Journal of biological chemistry 1997;272(40):24961-5.
1997: Gordon Y K Ng; George Varghese; H T Chung; J Trogadis; Philip Seeman; Brian F O'Dowd; Susan R George
Resistance of the dopamine D2L receptor to desensitization accompanies the up-regulation of receptors on to the surface of Sf9 cells.
Endocrinology 1997;138(10):4199-206.
1997: H Jin; R Zastawny; Susan R George; Brian F O'Dowd
Elimination of palmitoylation sites in the human dopamine D1 receptor does not affect receptor-G protein interaction.
European journal of pharmacology 1997;324(1):109-16.
1997: Brian F O'Dowd; Tuan V Nguyen; B P Jung; A Marchese; Regina Cheng; Hong-Qiang Heng; LF Kolakowski; Kevin R Lynch; Susan R George
Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.
Gene 1997;187(1):75-81.
1997: B P Jung; Tuan V Nguyen; LF Kolakowski; Kevin R Lynch; Hong-Qiang Heng; Susan R George; Brian F O'Dowd
Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1.
Biochemical and biophysical research communications 1997;230(1):69-72.
1996: LF Kolakowski; B P Jung; Tuan V Nguyen; M P Johnson; Kevin R Lynch; Regina Cheng; Hong-Qiang Heng; Susan R George; Brian F O'Dowd
Characterization of a human gene related to genes encoding somatostatin receptors.
FEBS letters 1996;398(2-3):253-8.
1996: Y Pak; A Kouvelas; MA Scheideler; J Rasmussen; Brian F O'Dowd; Susan R George
Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein.
Molecular pharmacology 1996;50(5):1214-22.
1996: Brian F O'Dowd; Tuan V Nguyen; Kevin R Lynch; LF Kolakowski; M Thompson; Regina Cheng; A Marchese; G Ng; Hong-Qiang Heng; Susan R George
A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain.
FEBS letters 1996;394(3):325-9.
1996: Gordon Y K Ng; Brian F O'Dowd; S P Lee; H T Chung; Mark R Brann; Philip Seeman; Susan R George
Dopamine D2 receptor dimers and receptor-blocking peptides.
Biochemical and biophysical research communications 1996;227(1):200-4.
1996: Gordon Y K Ng; Brian F O'Dowd; Susan R George
Genotypic differences in mesolimbic enkephalin gene expression in DBA/2J and C57BL/6J inbred mice.
European journal of pharmacology 1996;311(1):45-52.
1996: M Heiber; A Marchese; Tuan V Nguyen; Hong-Qiang Heng; Susan R George; Brian F O'Dowd
A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3.
Genomics 1996;32(3):462-5.
1996: S Lam; Y Shen; Tuan V Nguyen; T L Messier; Mark R Brann; D Comings; Susan R George; Brian F O'Dowd
A serotonin receptor gene (5HT1A) variant found in a Tourette's syndrome patient.
Biochemical and biophysical research communications 1996;219(3):853-8.
1995: T Nguyen; Laurie Erb; Gary A Weisman; A Marchese; Hong-Qiang Heng; Richard C Garrad; Susan R George; John T Turner; Brian F O'Dowd
Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene.
The Journal of biological chemistry 1995;270(52):30845-8.
1995: Gordon Y K Ng; J Trogadis; J Stevens; M Bouvier; Brian F O'Dowd; Susan R George
Agonist-induced desensitization of dopamine D1 receptor-stimulated adenylyl cyclase activity is temporally and biochemically separated from D1 receptor internalization.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10157-61.
1995: Brian F O'Dowd; MA Scheideler; Tuan V Nguyen; Regina Cheng; J S Rasmussen; A Marchese; R Zastawny; Hong-Qiang Heng; Lap-Chee Tsui; X Shi
The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.
Genomics 1995;28(1):84-91.
1995: Timothy Beischlag; A Marchese; James Meador-Woodruff; S P Damask; Brian F O'Dowd; Rachel F Tyndale; Hubert H M Van Tol; Philip Seeman; Hyman B Niznik
The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region.
Biochemistry 1995;34(17):5960-70.
1995: J E Trogadis; G Y Ng; Brian F O'Dowd; Susan R George; J K Stevens
Dopamine D1 receptor distribution in Sf9 cells imaged by confocal microscopy: a quantitative evaluation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(5):497-506.
1995: Susan R George; T Fan; G Y Ng; S Y Jung; Brian F O'Dowd; C A Naranjo
Low endogenous dopamine function in brain predisposes to high alcohol preference and consumption: reversal by increasing synaptic dopamine.
The Journal of pharmacology and experimental therapeutics 1995;273(1):373-9.
1995: A Marchese; Timothy Beischlag; Tuan V Nguyen; Hyman B Niznik; RL Weinshank; Susan R George; Brian F O'Dowd
Two gene duplication events in the human and primate dopamine D5 receptor gene family.
Gene 1995;154(2):153-8.
1994: A Marchese; Regina Cheng; M C Lee; C A Porter; M Heiber; Morris Goodman; Susan R George; Brian F O'Dowd
Mapping studies of two G protein-coupled receptor genes: an amino acid difference may confer a functional variation between a human and rodent receptor.
Biochemical and biophysical research communications 1994;205(3):1952-8.
1994: Susan R George; R L Zastawny; R Briones-Urbina; Regina Cheng; Tuan V Nguyen; M Heiber; A Kouvelas; A S Chan; Brian F O'Dowd
Distinct distributions of mu, delta and kappa opioid receptor mRNA in rat brain.
Biochemical and biophysical research communications 1994;205(2):1438-44.
1994: Gordon Y K Ng; Brian F O'Dowd; Susan R George
Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains.
European journal of pharmacology 1994;269(3):349-64.
1994: Gordon Y K Ng; Brian F O'Dowd; M Caron; M Dennis; Mark R Brann; Susan R George
Phosphorylation and palmitoylation of the human D2L dopamine receptor in Sf9 cells.
Journal of neurochemistry 1994;63(5):1589-95.
1994: A Marchese; J M Docherty; Tuan V Nguyen; M Heiber; Regina Cheng; Hong-Qiang Heng; Lap-Chee Tsui; X Shi; Susan R George; Brian F O'Dowd
Cloning of human genes encoding novel G protein-coupled receptors.
Genomics 1994;23(3):609-18.
1994: Lisanne G Laurier; Brian F O'Dowd; Susan R George
Heterogeneous tissue-specific transcription of dopamine receptor subtype messenger RNA in rat brain.
Brain research. Molecular brain research 1994;25(3-4):344-50.
1994: R L Zastawny; Susan R George; Tuan V Nguyen; Regina Cheng; J Tsatsos; R Briones-Urbina; Brian F O'Dowd
Cloning, characterization, and distribution of a mu-opioid receptor in rat brain.
Journal of neurochemistry 1994;62(6):2099-105.
1994: Gordon Y K Ng; B Mouillac; Susan R George; M Caron; M Dennis; M Bouvier; Brian F O'Dowd
Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor.
European journal of pharmacology 1994;267(1):7-19.
1994: W Z Ren; G Y Ng; RX Wang; P H Wu; Brian F O'Dowd; Daniel H Osmond; Susan R George; Choong-Chin Liew
The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations.
Brain research. Molecular brain research 1994;22(1-4):173-85.
1993: Brian F O'Dowd; M Heiber; A Chan; Hong-Qiang Heng; Lap-Chee Tsui; J L Kennedy; X Shi; A Petronis; Susan R George; Tuan V Nguyen
A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11.
Gene 1993;136(1-2):355-60.
1993: Gordon Y K Ng; Susan R George; R L Zastawny; M Caron; M Bouvier; M Dennis; Brian F O'Dowd
Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition.
Biochemistry 1993;32(43):11727-33.
1993: M Tomic; Philip Seeman; Susan R George; Brian F O'Dowd
Dopamine D1 receptor mutagenesis: role of amino acids in agonist and antagonist binding.
Biochemical and biophysical research communications 1993;191(3):1020-7.
1993: Brian F O'Dowd
Structures of dopamine receptors.
Journal of neurochemistry 1993;60(3):804-16.
1993: Tuan V Nguyen; A Marchese; J L Kennedy; A Petronis; S J Peroutka; P H Wu; Brian F O'Dowd
An Alu sequence interrupts a human 5-hydroxytryptamine1D receptor pseudogene.
Gene 1993;124(2):295-301.
1992: Y Lu; Brian F O'Dowd; H Orrego; Yedy Israel
Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase.
Biochemical and biophysical research communications 1992;189(2):749-58.
1992: D Oksenberg; S A Marsters; Brian F O'Dowd; H Jin; S Havlik; S J Peroutka; Avi Ashkenazi
A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors.
Nature 1992;360(6400):161-3.
1992: Brian F O'Dowd
Repeat sequences in the gene encoding the human D4 dopamine receptor.
Gene 1992;118(2):301-2.
1992: S J Mihic; Bart N M Van Berckel; Brian F O'Dowd; Tuan V Nguyen; P H Wu
Effects of sedatives on GABA-mediated chloride flux into cerebral cortical microsacs prepared from emotional and non-emotional mice.
European journal of pharmacology 1992;218(2-3):283-6.
1992: H Jin; D Oksenberg; Avi Ashkenazi; S J Peroutka; AM Duncan; Richard Rozmahel; Y Yang; G Mengod; J M Palacios; Brian F O'Dowd
Characterization of the human 5-hydroxytryptamine1B receptor.
The Journal of biological chemistry 1992;267(9):5735-8.
1992: Guadalupe Mengod; M T Villaró; G B Landwehrmeyer; M I Martinez-Mir; Hyman B Niznik; Roger K Sunahara; Philip Seeman; Brian F O'Dowd; Alphonse Probst; J M Palacios
Visualization of dopamine D1, D2 and D3 receptor mRNAs in human and rat brain.
Neurochemistry international 1992;20 Suppl():33S-43S.
1991: Tuan V Nguyen; J Bard; H Jin; D Taruscio; D C Ward; James L Kennedy; RL Weinshank; Philip Seeman; Brian F O'Dowd
Human dopamine D5 receptor pseudogenes.
Gene 1991;109(2):211-8.
1991: T Nguyen; Roger K Sunahara; A Marchese; Hubert H M Van Tol; Philip Seeman; Brian F O'Dowd
Transcription of a human dopamine D5 pseudogene.
Biochemical and biophysical research communications 1991;181(1):16-21.
1991: Guadalupe Mengod; M Teresa Vilaró; Hyman B Niznik; Roger K Sunahara; Philip Seeman; Brian F O'Dowd; J M Palacios
Visualization of a dopamine D1 receptor mRNA in human and rat brain.
Brain research. Molecular brain research 1991;10(2):185-91.
1991: Roger K Sunahara; Hong-Chang Guan; Brian F O'Dowd; Philip Seeman; Lisanne G Laurier; Gordon Y K Ng; Susan R George; J Torchia; Hubert H M Van Tol; Hyman B Niznik
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
Nature 1991;350(6319):614-9.
1991: D M Weiner; Allan Levey; Roger K Sunahara; Hyman B Niznik; Brian F O'Dowd; Philip Seeman; Mark R Brann
D1 and D2 dopamine receptor mRNA in rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1859-63.