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Christian Oefner

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Staphylococcus aureus

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Protein Binding

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Christian Oefner; Sabine Pierau; Henk Schulz; Glenn E Dale
Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV.
Christian Oefner; Henk Schulz; Allan D'Arcy; Glenn E Dale
Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography.
Aengus Mac Sweeney; Roland Lange; Roberta P M Fernandes; Henk Schulz; Glenn E Dale; Alice Douangamath; Philip J Proteau; Christian Oefner
The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.

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All Publications

2007: Christian Oefner; Sabine Pierau; Henk Schulz; Glenn E Dale
Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 9):975-81.
2006: Christian Oefner; Henk Schulz; Allan D'Arcy; Glenn E Dale
Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 6):613-8.
2005: Aengus Mac Sweeney; Roland Lange; Roberta P M Fernandes; Henk Schulz; Glenn E Dale; Alice Douangamath; Philip J Proteau; Christian Oefner
The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
Journal of molecular biology 2005;345(1):115-27.
2004: Alice Douangamath; Glenn E Dale; Allan D'Arcy; Michael Almstetter; Robert Eckl; Annabelle Frutos-Hoener; Bernd Henkel; Katrin Illgen; Sven Nerdinger; Henk Schulz; Aengus Mac Sweeney; Aengus MacSweeney; Michael Thormann; Andreas Treml; Sabine Pierau; Sjoerd Wadman; Christian Oefner
Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate.
Journal of medicinal chemistry 2004;47(6):1325-8.
2004: Christian Oefner; Bernard P Roques; Marie-Claude Fournie-Zaluski; Glenn E Dale
Structural analysis of neprilysin with various specific and potent inhibitors.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 2):392-6.
2003: Christian Oefner; Alice Douangamath; Allan D'Arcy; Sascha Häfeli; Daniel Mareque; Aengus Mac Sweeney; Juan Padilla; Sabine Pierau; Henk Schulz; Michael Thormann; Sjoerd Wadman; Glenn E Dale
The 1.15A crystal structure of the Staphylococcus aureus methionyl-aminopeptidase and complexes with triazole based inhibitors.
Journal of molecular biology 2003;332(1):13-21.
2003: Christian Oefner; Allan D'Arcy; Aengus Mac Sweeney; Sabine Pierau; Rana Gardiner; Glenn E Dale
High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 7):1206-12.
2003: Glenn E Dale; Christian Oefner; Allan D'Arcy
The protein as a variable in protein crystallization.
Journal of structural biology 2003;142(1):88-97.
2001: Daniel Bur; Glenn E Dale; Christian Oefner
A three-dimensional model of endothelin-converting enzyme (ECE) based on the X-ray structure of neutral endopeptidase 24.11 (NEP).
Protein engineering 2001;14(5):337-41.
2000: Glenn E Dale; B D'Arcy; C Yuvaniyama; B Wipf; Christian Oefner; Allan D'Arcy
Purification and crystallization of the extracellular domain of human neutral endopeptidase (neprilysin) expressed in Pichia pastoris.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 7):894-7.
2000: Christian Oefner; Allan D'Arcy; M Hennig; Fritz K Winkler; Glenn E Dale
Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.
Journal of molecular biology 2000;296(2):341-9.
1999: R Güller; Alfred Binggeli; V Breu; Daniel Bur; Walter Fischli; G Hirth; C Jenny; M Kansy; F Montavon; M Müller; Christian Oefner; H Stadler; E Vieira; M Wilhelm; W Wostl; Hans Peter Märki
Piperidine-renin inhibitors compounds with improved physicochemical properties.
Bioorganic & medicinal chemistry letters 1999;9(10):1403-8.
1999: E Vieira; Alfred Binggeli; V Breu; Daniel Bur; Walter Fischli; R Güller; G Hirth; Hans Peter Märki; M Müller; Christian Oefner; M Scalone; H Stadler; M Wilhelm; W Wostl
Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site.
Bioorganic & medicinal chemistry letters 1999;9(10):1397-402.
1999: M Hennig; Glenn E Dale; Allan D'Arcy; Franck Danel; S Fischer; C P Gray; S Jolidon; F Müller; Malcolm G P Page; P Pattison; Christian Oefner
The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae.
Journal of molecular biology 1999;287(2):211-9.
1999: Christian Oefner; Alfred Binggeli; V Breu; Daniel Bur; Jean-Paul Clozel; Allan D'Arcy; Arnulf Dorn; Walter Fischli; F Grüninger; R Güller; G Hirth; Hans Peter Märki; S Mathews; M M ller; RG Ridley; H Stadler; E Vieira; M Wilhelm; Fritz K Winkler; W Wostl
Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases?
Chemistry & biology 1999;6(3):127-31.
1998: I Heinze-Krauss; Peter Angehrn; R L Charnas; K Gubernator; E M Gutknecht; Christian Hubschwerlen; Malgosia Kania; Christian Oefner; Malcolm G P Page; S Sogabe; Jean-Luc Specklin; F Winkler
Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams.
Journal of medicinal chemistry 1998;41(21):3961-71.
1998: M Hennig; Allan D'Arcy; I C Hampele; Malcolm G P Page; Christian Oefner; Glenn E Dale
Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus.
Nature structural biology 1998;5(5):357-62.
1998: RP Moon; Daniel Bur; Hansruedi Loetscher; Allan D'Arcy; L Tyas; Christian Oefner; F Grueninger-Leitch; D Mona; K Rupp; Arnulf Dorn; Hugues Matile; U Certa; Colin Berry; John Kay; RG Ridley
Studies on plasmepsins I and II from the malarial parasite Plasmodium falciparum and their exploitation as drug targets.
Advances in experimental medicine and biology 1998;436():397-406.
1997: I C Hampele; Allan D'Arcy; Glenn E Dale; Dirk Kostrewa; J Nielsen; Christian Oefner; Malcolm G P Page; Hans-Joachim Schönfeld; D Stüber; Rudolf L Then
Structure and function of the dihydropteroate synthase from Staphylococcus aureus.
Journal of molecular biology 1997;268(1):21-30.
1997: Glenn E Dale; C Broger; Allan D'Arcy; P G Hartman; R DeHoogt; S Jolidon; I Kompis; Alexander Michael Labhardt; Hanno Langen; Hans H Locher; Malcolm G P Page; D Stüber; Rudolf L Then; B Wipf; Christian Oefner
A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance.
Journal of molecular biology 1997;266(1):23-30.
1996: S Mathews; Heinz Döbeli; M Pruschy; R Bosser; Allan D'Arcy; Christian Oefner; M Zulauf; R Gentz; V Breu; Hugues Matile; J Schlaeger; Walter Fischli
Recombinant human renin produced in different expression systems: biochemical properties and 3D structure.
Protein expression and purification 1996;7(1):81-91.
1995: Jan Tavernier; T Tuypens; Annick Verhee; G Plaetinck; R Devos; José Van der Heyden; Y Guisez; Christian Oefner
Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5194-8.
1993: Judith Murray-Rust; Neil McDonald; Tom L Blundell; M Hosang; Christian Oefner; F Winkler; R A Bradshaw
Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors.
Structure (London, England : 1993) 1993;1(2):153-9.
1993: Y Guisez; Christian Oefner; F K Winkler; E J Schlaeger; M Zulauf; José Van der Heyden; G Plaetinck; S Cornelis; Jan Tavernier; W Fiers
Expression, purification and crystallization of fully active, glycosylated human interleukin-5.
FEBS letters 1993;331(1-2):49-52.
1993: F K Winkler; D W Banner; Christian Oefner; Demetrius Tsernoglou; R S Brown; S P Heathman; R K Bryan; Philip D Martin; K Petratos; K S Wilson
The crystal structure of EcoRV endonuclease and of its complexes with cognate and non-cognate DNA fragments.
The EMBO journal 1993;12(5):1781-95.
1992: Christian Oefner; Allan D'Arcy; F K Winkler; B Eggimann; M Hosang
Crystal structure of human platelet-derived growth factor BB.
The EMBO journal 1992;11(11):3921-6.
1990: Christian Oefner; Allan D'Arcy; J J Daly; K Gubernator; R L Charnas; I Heinze; Christian Hubschwerlen; F K Winkler
Refined crystal structure of beta-lactamase from Citrobacter freundii indicates a mechanism for beta-lactam hydrolysis.
Nature 1990;343(6255):284-8.
1988: Christian Oefner; Allan D'Arcy; F K Winkler
Crystal structure of human dihydrofolate reductase complexed with folate.
European journal of biochemistry / FEBS 1988;174(2):377-85.