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Patrick O'Farrell

Research Profile

Chemicals & Drugs

Anatomy

Nonmammalian Embryo

Concepts & Ideas

Physiology

Genes & Molecular Sequences

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Publications

TOP 3
Jeffrey A Farrell; Patrick H O'Farrell
Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling.
Kai Yuan; Jeffrey A Farrell; Patrick H O'Farrell
Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis.
Jeffrey A Farrell; Antony W Shermoen; Kai Yuan; Patrick H O'Farrell
Embryonic onset of late replication requires Cdc25 down-regulation.

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All Publications

2013: Jeffrey A Farrell; Patrick H O'Farrell
Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling.
Current biology : CB 2013;23(2):118-26.
2012: Kai Yuan; Jeffrey A Farrell; Patrick H O'Farrell
Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis.
The Journal of cell biology 2012;198(6):973-80.
2012: Jeffrey A Farrell; Antony W Shermoen; Kai Yuan; Patrick H O'Farrell
Embryonic onset of late replication requires Cdc25 down-regulation.
Genes & development 2012;26(7):714-25.
2011: Patrick H O'Farrell
Quiescence: early evolutionary origins and universality do not imply uniformity.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1584):3498-507.
2010: Antony W Shermoen; Mark L McCleland; Patrick H O'Farrell
Developmental control of late replication and S phase length.
Current biology : CB 2010;20(23):2067-77.
2009: Mark L McCleland; Antony W Shermoen; Patrick H O'Farrell
DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos.
The Journal of cell biology 2009;187(1):7-14.
2009: Pascale F Dijkers; Patrick H O'Farrell
Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade.
Molecular biology of the cell 2009;20(18):4083-90.
2009: Mark L McCleland; Jeffrey A Farrell; Patrick H O'Farrell
Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo.
The Journal of cell biology 2009;184(5):639-46.
2008: Soo-Jung Lee; Renny Feldman; Patrick H O'Farrell
An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells.
Molecular biology of the cell 2008;19(10):4051-61.
2008: Hong Xu; Steven Z DeLuca; Patrick H O'Farrell
Manipulating the metazoan mitochondrial genome with targeted restriction enzymes.
Science (New York, N.Y.) 2008;321(5888):575-7.
2008: Gilles R X Hickson; Patrick H O'Farrell
Anillin: a pivotal organizer of the cytokinetic machinery.
Biochemical Society transactions 2008;36(Pt 3):439-41.
2008: Mark L McCleland; Patrick H O'Farrell
RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle.
Current biology : CB 2008;18(4):245-54.
2008: Gilles R X Hickson; Patrick H O'Farrell
Rho-dependent control of anillin behavior during cytokinesis.
The Journal of cell biology 2008;180(2):285-94.
2007: Pascale F Dijkers; Patrick H O'Farrell
Drosophila calcineurin promotes induction of innate immune responses.
Current biology : CB 2007;17(23):2087-93.
2006: Maria-Carla Saleh; Ronald P Van Rij; Armin Hekele; Amethyst Gillis; Edan Foley; Patrick H O'Farrell; Raul Andino
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing.
Nature cell biology 2006;8(8):793-802.
2006: Gilles R X Hickson; Arnaud Echard; Patrick H O'Farrell
Rho-kinase controls cell shape changes during cytokinesis.
Current biology : CB 2006;16(4):359-70.
2006: Shannon L Stroschein-Stevenson; Edan Foley; Patrick H O'Farrell; Alexander D Johnson
Identification of Drosophila gene products required for phagocytosis of Candida albicans.
PLoS biology 2006;4(1):e4.
2004: Arnaud Echard; Gilles R X Hickson; Edan Foley; Patrick H O'Farrell
Terminal cytokinesis events uncovered after an RNAi screen.
Current biology : CB 2004;14(18):1685-93.
2004: Edan Foley; Patrick H O'Farrell
Functional dissection of an innate immune response by a genome-wide RNAi screen.
PLoS biology 2004;2(8):E203.
2004: Patrick H O'Farrell; Jason Stumpff; Tin Tin Su
Embryonic cleavage cycles: how is a mouse like a fly?
Current biology : CB 2004;14(1):R35-45.
2003: Jean-Karim Hériché; Dan Ang; Ethan Bier; Patrick H O'Farrell
Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila.
BMC genetics 2003;4():9.
2003: Devin H Parry; Gilles R X Hickson; Patrick H O'Farrell
Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase.
Current biology : CB 2003;13(8):647-53.
2003: Arnaud Echard; Patrick H O'Farrell
The degradation of two mitotic cyclins contributes to the timing of cytokinesis.
Current biology : CB 2003;13(5):373-83.
2003: Rita O Teodoro; Patrick H O'Farrell
Nitric oxide-induced suspended animation promotes survival during hypoxia.
The EMBO journal 2003;22(3):580-7.
2003: Edan Foley; Patrick H O'Farrell
Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila.
Genes & development 2003;17(1):115-25.
2003: Smruti J Vidwans; Mei Lie Wong; Patrick H O'Farrell
Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation.
Journal of cell science 2003;116(Pt 1):137-43.
2002: Smruti J Vidwans; Paul J DiGregorio; Antony W Shermoen; Barrett Foat; Janet Iwasa; Nikita Yakubovich; Patrick H O'Farrell
Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos.
Current biology : CB 2002;12(10):829-33.
2001: Patrick H O'Farrell
Triggering the all-or-nothing switch into mitosis.
Trends in cell biology 2001;11(12):512-9.
2001: Tin Tin Su; Devin H Parry; B Donahoe; C T Chien; Patrick H O'Farrell; Amanda Purdy
Cell cycle roles for two 14-3-3 proteins during Drosophila development.
Journal of cell science 2001;114(Pt 19):3445-54.
2001: Devin H Parry; Patrick H O'Farrell
The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis.
Current biology : CB 2001;11(9):671-83.
2001: Patrick H O'Farrell
Conserved responses to oxygen deprivation.
The Journal of clinical investigation 2001;107(6):671-4.
2001: Paul J DiGregorio; Jeffrey A Ubersax; Patrick H O'Farrell
Hypoxia and nitric oxide induce a rapid, reversible cell cycle arrest of the Drosophila syncytial divisions.
The Journal of biological chemistry 2001;276(3):1930-7.
2000: D Price; Simon Rabinovitch; Patrick H O'Farrell; Shelagh D Campbell
Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis.
Genetics 2000;155(1):159-66.
1999: Smruti J Vidwans; Mei Lie Wong; Patrick H O'Farrell
Mitotic regulators govern progress through steps in the centrosome duplication cycle.
The Journal of cell biology 1999;147(7):1371-8.
1999: Edan Foley; Patrick H O'Farrell; Frank Sprenger
Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes.
Current biology : CB 1999;9(23):1392-402.
1999: GS Wilkie; A W Shermoen; Patrick H O'Farrell; Ilan Davis
Transcribed genes are localized according to chromosomal position within polarized Drosophila embryonic nuclei.
Current biology : CB 1999;9(21):1263-6.
1999: Smruti J Vidwans; Patrick H O'Farrell
Cytoskeleton: centrosom-in absentia.
Current biology : CB 1999;9(20):R764-6.
1999: Tin Tin Su; Shelagh D Campbell; Patrick H O'Farrell
Drosophila grapes/CHK1 mutants are defective in cyclin proteolysis and coordination of mitotic events.
Current biology : CB 1999;9(16):919-22.
1999: J A Wingrove; Patrick H O'Farrell
Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila.
Cell 1999;98(1):105-14.
1998: Tin Tin Su; Patrick H O'Farrell
Size control: cell proliferation does not equal growth.
Current biology : CB 1998;8(19):R687-9.
1998: Tin Tin Su; Frank Sprenger; Paul J DiGregorio; Shelagh D Campbell; Patrick H O'Farrell
Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation.
Genes & development 1998;12(10):1495-503.
1998: Tin Tin Su; Shelagh D Campbell; Patrick H O'Farrell
The cell cycle program in germ cells of the Drosophila embryo.
Developmental biology 1998;196(2):160-70.
1998: PJ Follette; Robert J Duronio; Patrick H O'Farrell
Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila.
Current biology : CB 1998;8(4):235-8.
1998: Tin Tin Su; Patrick H O'Farrell
Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles.
The Journal of cell biology 1998;140(3):451-60.
1998: Robert J Duronio; Peter C Bonnette; Patrick H O'Farrell
Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition.
Molecular and cellular biology 1998;18(1):141-51.
1997: Tin Tin Su; Patrick H O'Farrell
Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles.
The Journal of cell biology 1997;139(1):13-21.
1997: Frank Sprenger; Nikita Yakubovich; Patrick H O'Farrell
S-phase function of Drosophila cyclin A and its downregulation in G1 phase.
Current biology : CB 1997;7(7):488-99.
1997: Tin Tin Su; Nikita Yakubovich; Patrick H O'Farrell
Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis.
Gene 1997;192(2):283-9.
1997: N Serrano; Patrick H O'Farrell
Limb morphogenesis: connections between patterning and growth.
Current biology : CB 1997;7(3):R186-95.
1997: PJ Follette; Patrick H O'Farrell
Connecting cell behavior to patterning: lessons from the cell cycle.
Cell 1997;88(3):309-14.
1997: PJ Follette; Patrick H O'Farrell
Cdks and the Drosophila cell cycle.
Current opinion in genetics & development 1997;7(1):17-22.
1996: Robert J Duronio; A Brook; Nicholas J Dyson; Patrick H O'Farrell
E2F-induced S phase requires cyclin E.
Genes & development 1996;10(19):2505-13.
1996: V Leclerc; J P Tassan; Patrick H O'Farrell; Erich A Nigg; P Léopold
Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II.
Molecular biology of the cell 1996;7(4):505-13.
1996: Tin Tin Su; G Feger; Patrick H O'Farrell
Drosophila MCM protein complexes.
Molecular biology of the cell 1996;7(2):319-29.
1995: Shelagh D Campbell; Frank Sprenger; Bruce A Edgar; Patrick H O'Farrell
Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro.
Molecular biology of the cell 1995;6(10):1333-47.
1995: I Davis; C H Girdham; Patrick H O'Farrell
A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence.
Developmental biology 1995;170(2):726-9.
1995: J E Treisman; P J Follette; Patrick H O'Farrell; Gerald M Rubin
Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant.
Genes & development 1995;9(14):1709-15.
1995: Tin Tin Su; P J Follette; Patrick H O'Farrell
Qualifying for the license to replicate.
Cell 1995;81(6):825-8.
1995: Robert J Duronio; Patrick H O'Farrell
Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F.
Genes & development 1995;9(12):1456-68.
1995: Robert J Duronio; Patrick H O'Farrell; J E Xie; A Brook; Nicholas J Dyson
The transcription factor E2F is required for S phase during Drosophila embryogenesis.
Genes & development 1995;9(12):1445-55.
1994: Bruce A Edgar; D A Lehman; Patrick H O'Farrell
Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle.
Development (Cambridge, England) 1994;120(11):3131-43.
1994: Stephen DiNardo; J Heemskerk; Scott T. Dougan; Patrick H O'Farrell
The making of a maggot: patterning the Drosophila embryonic epidermis.
Current opinion in genetics & development 1994;4(4):529-34.
1994: J P Vincent; C H Girdham; Patrick H O'Farrell
A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics.
Developmental biology 1994;164(1):328-31.
1994: Robert J Duronio; Patrick H O'Farrell
Developmental control of a G1-S transcriptional program in Drosophila.
Development (Cambridge, England) 1994;120(6):1503-15.
1994: Bruce A Edgar; Frank Sprenger; Robert J Duronio; P Leopold; Patrick H O'Farrell
Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.
Genes & development 1994;8(4):440-52.
1994: C H Girdham; Patrick H O'Farrell
The use of photoactivatable reagents for the study of cell lineage in Drosophila embryogenesis.
Methods in cell biology 1994;44():533-43.
1993: B Kalionis; Patrick H O'Farrell
A universal target sequence is bound in vitro by diverse homeodomains.
Mechanisms of development 1993;43(1):57-70.
1992: J P Vincent; Patrick H O'Farrell
The state of engrailed expression is not clonally transmitted during early Drosophila development.
Cell 1992;68(5):923-31.
1991: A W Shermoen; Patrick H O'Farrell
Progression of the cell cycle through mitosis leads to abortion of nascent transcripts.
Cell 1991;67(2):303-10.
1991: P Léopold; Patrick H O'Farrell
An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins.
Cell 1991;66(6):1207-16.
1991: J Heemskerk; Stephen DiNardo; R Kostriken; Patrick H O'Farrell
Multiple modes of engrailed regulation in the progression towards cell fate determination.
Nature 1991;352(6334):404-10.
1991: J B Jaynes; Patrick H O'Farrell
Active repression of transcription by the engrailed homeodomain protein.
The EMBO journal 1991;10(6):1427-33.
1991: Patrick H O'Farrell; P Léopold
A consensus of cyclin sequences reveals homology with the ras oncogene.
Cold Spring Harbor symposia on quantitative biology 1991;56():83-92.
1991: Christian F Lehner; N Yakubovich; Patrick H O'Farrell
Exploring the role of Drosophila cyclin A in the regulation of S phase.
Cold Spring Harbor symposia on quantitative biology 1991;56():465-75.
1990: C F Lehner; Patrick H O'Farrell
Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant.
The EMBO journal 1990;9(11):3573-81.
1990: Bruce A Edgar; Patrick H O'Farrell
The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string.
Cell 1990;62(3):469-80.
1990: J P Vincent; J A Kassis; Patrick H O'Farrell
A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos.
The EMBO journal 1990;9(8):2573-8.
1990: C F Lehner; Patrick H O'Farrell
The roles of Drosophila cyclins A and B in mitotic control.
Cell 1990;61(3):535-47.
1989: Patrick H O'Farrell; Bruce A Edgar; D Lakich; C F Lehner
Directing cell division during development.
Science (New York, N.Y.) 1989;246(4930):635-40.
1989: J A Kassis; C Desplan; D K Wright; Patrick H O'Farrell
Evolutionary conservation of homeodomain-binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailed.
Molecular and cellular biology 1989;9(10):4304-11.
1989: Bruce A Edgar; Patrick H O'Farrell
Genetic control of cell division patterns in the Drosophila embryo.
Cell 1989;57(1):177-87.
1989: C F Lehner; Patrick H O'Farrell
Expression and function of Drosophila cyclin A during embryonic cell cycle progression.
Cell 1989;56(6):957-68.
1988: J B Jaynes; Patrick H O'Farrell
Activation and repression of transcription by homoeodomain-containing proteins that bind a common site.
Nature 1988;336(6201):744-9.
1988: C Desplan; J Theis; Patrick H O'Farrell
The sequence specificity of homeodomain-DNA interaction.
Cell 1988;54(7):1081-90.
1988: Stephen DiNardo; E Sher; J Heemskerk-Jongens; J A Kassis; Patrick H O'Farrell
Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis.
Nature 1988;332(6165):604-9.
1988: S B Carroll; Stephen DiNardo; Patrick H O'Farrell; R A White; M P Scott
Temporal and spatial relationships between segmentation and homeotic gene expression in Drosophila embryos: distributions of the fushi tarazu, engrailed, Sex combs reduced, Antennapedia, and Ultrabithorax proteins.
Genes & development 1988;2(3):350-60.
1987: Stephen DiNardo; Patrick H O'Farrell
Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes.
Genes & development 1987;1(10):1212-25.
1986: J A Kassis; S J Poole; D K Wright; Patrick H O'Farrell
Sequence conservation in the protein coding and intron regions of the engrailed transcription unit.
The EMBO journal 1986;5(13):3583-9.
1985: C Desplan; J Theis; Patrick H O'Farrell
The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity.
Nature 1985;318(6047):630-5.
1985: J A Kassis; M L Wong; Patrick H O'Farrell
Electron microscopic heteroduplex mapping identifies regions of the engrailed locus that are conserved between Drosophila melanogaster and Drosophila virilis.
Molecular and cellular biology 1985;5(12):3600-9.
1985: Stephen DiNardo; J M Kuner; J Theis; Patrick H O'Farrell
Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein.
Cell 1985;43(1):59-69.
1985: J M Kuner; M Nakanishi; Z Ali; B Drees; E Gustavson; J Theis; L Kauvar; Thomas B Kornberg; Patrick H O'Farrell
Molecular cloning of engrailed: a gene involved in the development of pattern in Drosophila melanogaster.
Cell 1985;42(1):309-16.
1985: T Kornberg; I Sidén; Patrick H O'Farrell; M Simon
The engrailed locus of Drosophila: in situ localization of transcripts reveals compartment-specific expression.
Cell 1985;40(1):45-53.
1985: Patrick H O'Farrell; C Desplan; Stephen DiNardo; J A Kassis; J M Kuner; E Sher; J Theis; D Wright
Embryonic pattern in Drosophila: the spatial distribution and sequence-specific DNA binding of engrailed protein.
Cold Spring Harbor symposia on quantitative biology 1985;50():235-42.