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Rienk Offringa

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Bart Burington; Peng Yue; Xiaoyan Shi; Ranjana Advani; Jeffrey T Lau; Jenille Tan; Susanna Stinson; Jeremy Stinson; Thomas Januario; Sven de Vos; Stephen Ansell; Andres Forero-Torres; Grazyna Fedorowicz; Teddy T C Yang; Kristi Elkins; Changchun Du; Sankar Mohan; Nancy Yu; Zora Modrusan; Somasekar Seshagiri; Shang-Fan Yu; Ajay Pandita; Hartmut Koeppen; Dorothy French; Andrew G Polson; Rienk Offringa; Nancy Whiting; Allen Ebens; David Dornan
CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma.
Nicholas S Wilson; Becky Yang; Annie Yang; Stefanie Loeser; Scot A Marsters; David Lawrence; Yun Li; Robert M Pitti; Klara Totpal; Sharon Yee; Sarajane Ross; Jean-Michel Vernes; Yanmei Lu; Cam Adams; Rienk Offringa; Bob Kelley; Sarah G Hymowitz; Dylan Daniel; Gloria Meng; Avi Ashkenazi
An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells.
Rezaul Karim; Craig Meyers; Claude Backendorf; Kristina Ludigs; Rienk Offringa; Gert-Jan B van Ommen; Cornelis J M Melief; Sjoerd H van der burg; Judith M Boer
Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes.

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All Publications

2011: Bart Burington; Peng Yue; Xiaoyan Shi; Ranjana Advani; Jeffrey T Lau; Jenille Tan; Susanna Stinson; Jeremy Stinson; Thomas Januario; Sven de Vos; Stephen Ansell; Andres Forero-Torres; Grazyna Fedorowicz; Teddy T C Yang; Kristi Elkins; Changchun Du; Sankar Mohan; Nancy Yu; Zora Modrusan; Somasekar Seshagiri; Shang-Fan Yu; Ajay Pandita; Hartmut Koeppen; Dorothy French; Andrew G Polson; Rienk Offringa; Nancy Whiting; Allen Ebens; David Dornan
CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma.
Science translational medicine 2011;3(74):74ra22.
2011: Nicholas S Wilson; Becky Yang; Annie Yang; Stefanie Loeser; Scot A Marsters; David Lawrence; Yun Li; Robert M Pitti; Klara Totpal; Sharon Yee; Sarajane Ross; Jean-Michel Vernes; Yanmei Lu; Cam Adams; Rienk Offringa; Bob Kelley; Sarah G Hymowitz; Dylan Daniel; Gloria Meng; Avi Ashkenazi
An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells.
Cancer cell 2011;19(1):101-13.
2011: Rezaul Karim; Craig Meyers; Claude Backendorf; Kristina Ludigs; Rienk Offringa; Gert-Jan B van Ommen; Cornelis J M Melief; Sjoerd H van der burg; Judith M Boer
Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes.
PloS one 2011;6(3):e17848.
2010: Muriel van den Hende; Anke Redeker; Kitty M C Kwappenberg; Kees L M C Franken; Jan Wouter Drijfhout; Jaap Oostendorp; Rob Valentijn; Loraine M Fathers; Marij J P Welters; Cornelis J M Melief; Gemma G Kenter; Sjoerd H van der burg; Rienk Offringa
Evaluation of immunological cross-reactivity between clade A9 high-risk human papillomavirus types on the basis of E6-Specific CD4+ memory T cell responses.
The Journal of infectious diseases 2010;202(8):1200-11.
2010: Marieke F Fransen; Marianne J B van Stipdonk; Marjolein Sluijter; Stephen P Schoenberger; Cornelis J Melief; Rienk Offringa
Separate roles for antigen recognition and lymph node inflammation in CD8+ memory T cell formation.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(6):3167-73.
2010: Fang Huang; Marcelo Kemel Zago; Lindy Abas; Arnoud van Marion; Carlos Samuel Galván-Ampudia; Rienk Offringa
Phosphorylation of conserved PIN motifs directs Arabidopsis PIN1 polarity and auxin transport.
The Plant cell 2010;22(4):1129-42.
2010: Cláudia C Oliveira; Peter van Veelen; Bianca Querido; Arnoud de Ru; Marjolein Sluijter; Sandra Laban; Jan W Drijfhout; Sjoerd H van der burg; Rienk Offringa; Thorbald van Hall
The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects.
The Journal of experimental medicine 2010;207(1):207-21.
2009: Gemma G Kenter; Marij J P Welters; Rob Valentijn; Margriet J G Lowik; Dorien M A Berends-van der Meer; Annelies P G Vloon; Farah Essahsah; Lorraine M Fathers; Rienk Offringa; Jan Wouter Drijfhout; Amon R Wafelman; Jaap Oostendorp; Gert Jan Fleuren; Sjoerd H van der burg; Cornelis J M Melief
Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.
The New England journal of medicine 2009;361(19):1838-47.
2009: Marianne J B van Stipdonk; Daniel Badia-Martinez; Marjolein Sluijter; Rienk Offringa; Thorbald van Hall; Adnane Achour
Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100.
Cancer research 2009;69(19):7784-92.
2009: Rienk Offringa
Antigen choice in adoptive T-cell therapy of cancer.
Current opinion in immunology 2009;21(2):190-9.
2008: Rinke Bos; Suzanne van Duikeren; Hans Morreau; Kees L M C Franken; Schumacher Ton; John B Haanen; Sjoerd H van der burg; Cornelis J M Melief; Rienk Offringa
Balancing between antitumor efficacy and autoimmune pathology in T-cell-mediated targeting of carcinoembryonic antigen.
Cancer research 2008;68(20):8446-55.
2008: Jan Willem F Dierssen; Marjo Van Puijenbroek; David A Dezentjé; Gert Jan Fleuren; Cees J Cornelisse; Tom van Wezel; Rienk Offringa; Hans Morreau
Frequent mutations in the 3'-untranslated region of IFNGR1 lack functional impairment in microsatellite-unstable colorectal tumours.
European journal of human genetics : EJHG 2008;16(10):1235-9.
2008: Frank M Speetjens; Marjolein M Lauwen; Kees L M C Franken; Connie M Janssen-Van Rhijn; Suzanne van Duikeren; Sandra A Bres; Cornelis J H van de Velde; Cornelis J M Melief; Peter Kuppen; Sjoerd H van der burg; Hans Morreau; Rienk Offringa
Prediction of the immunogenic potential of frameshift-mutated antigens in microsatellite instable cancer.
International journal of cancer. Journal international du cancer 2008;123(4):838-45.
2008: Dave L Roelen; Daniëlle E M van den Boogaardt; Paula P M C van Miert; Karin Koekkoek; Rienk Offringa; Frans H J Claas
Differentially modulated dendritic cells induce regulatory T cells with different characteristics.
Transplant immunology 2008;19(3-4):220-8.
2008: Marianne J B van Stipdonk; Marjolein Sluijter; Wanda G H Han; Rienk Offringa
Development of CTL memory despite arrested clonal expansion.
European journal of immunology 2008;38(7):1839-46.
2008: Muriel van den Hende; Mariëtte I E Van Poelgeest; Jeanette M van der Hulst; J de Jong; Jan Wouter Drijfhout; Gert Jan Fleuren; Rob Valentijn; Amon R Wafelman; Gijs M Slappendel; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg; Gemma G Kenter
Skin reactions to human papillomavirus (HPV) 16 specific antigens intradermally injected in healthy subjects and patients with cervical neoplasia.
International journal of cancer. Journal international du cancer 2008;123(1):146-52.
2008: Martijn Bijker; Susan J F van den Eeden; Kees L M C Franken; Cornelis J M Melief; Sjoerd H van der burg; Rienk Offringa
Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation.
European journal of immunology 2008;38(4):1033-42.
2008: Marjolein M Lauwen; Sander Zwaveling; Linda de Quartel; Sandra C Ferreira Mota; Janine A C Grashorn; Cornelis J M Melief; Sjoerd H van der burg; Rienk Offringa
Self-tolerance does not restrict the CD4+ T-helper response against the p53 tumor antigen.
Cancer research 2008;68(3):893-900.
2008: Sytse J Piersma; Marij J P Welters; Jeanette M van der Hulst; Judith N Kloth; Kitty M C Kwappenberg; Baptist J Trimbos; Cornelis J M Melief; Bart W J Hellebrekers; Gert Jan Fleuren; Gemma G Kenter; Rienk Offringa; Sjoerd H van der burg
Human papilloma virus specific T cells infiltrating cervical cancer and draining lymph nodes show remarkably frequent use of HLA-DQ and -DP as a restriction element.
International journal of cancer. Journal international du cancer 2008;122(3):486-94.
2008: Ence Darmo Jaya Supena; Budi Winarto; Tjitske Riksen; Ewa Dubas; André A M van Lammeren; Rienk Offringa; Kim Boutilier; Jan Custers
Regeneration of zygotic-like microspore-derived embryos suggests an important role for the suspensor in early embryo patterning.
Journal of experimental botany 2008;59(4):803-14.
2008: Marij J P Welters; Gemma G Kenter; Sytse J Piersma; Annelies P G Vloon; Margriet J G Löwik; Dorien M A Berends-van der Meer; Jan Wouter Drijfhout; Rob Valentijn; Amon R Wafelman; Jaap Oostendorp; Gert Jan Fleuren; Rienk Offringa; Cornelis J M Melief; Sjoerd H van der burg
Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):178-87.
2008: Gemma G Kenter; Marij J P Welters; Rob Valentijn; Margriet J G Lowik; Dorien M A Berends-van der Meer; Annelies P G Vloon; Jan Wouter Drijfhout; Amon R Wafelman; Jaap Oostendorp; Gert Jan Fleuren; Rienk Offringa; Sjoerd H van der burg; Cornelis J M Melief
Phase I immunotherapeutic trial with long peptides spanning the E6 and E7 sequences of high-risk human papillomavirus 16 in end-stage cervical cancer patients shows low toxicity and robust immunogenicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):169-77.
2007: Laurent Laplaze; Eva Benkova; Ilda Casimiro; Lies Maes; Steffen Vanneste; Ranjan Swarup; Dolf Weijers; Vanessa Calvo; Boris Parizot; Maria Begoña Herrera-Rodriguez; Rienk Offringa; Neil Graham; Patrick Doumas; Jiri Friml; Didier BOGUSZ; Tom Beeckman; Malcolm Bennett
Cytokinins act directly on lateral root founder cells to inhibit root initiation.
The Plant cell 2007;19(12):3889-900.
2007: Carlos S Galván-Ampudia; Rienk Offringa
Plant evolution: AGC kinases tell the auxin tale.
Trends in plant science 2007;12(12):541-7.
2007: Rinke Bos; Suzanne van Duikeren; Thorbald van Hall; Marjolein M Lauwen; Mark Parrington; Neil L Berinstein; Bryan McNeil; Cornelis J M Melief; Sjef Verbeek; Sjoerd H van der burg; Rienk Offringa
Characterization of antigen-specific immune responses induced by canarypox virus vaccines.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6115-22.
2007: Martijn Bijker; Susan J F van den Eeden; Kees L M C Franken; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg
CD8+ CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5033-40.
2007: Marta Michniewicz; Marcelo K Zago; Lindy Abas; Dolf Weijers; Alois Schweighofer; Irute Meskiene; Marcus G Heisler; Carolyn Ohno; Jing Zhang; Fang Huang; Rebecca Schwab; Detlef Weigel; Elliot M Meyerowitz; Christian Luschnig; Rienk Offringa; Jirí Friml
Antagonistic regulation of PIN phosphorylation by PP2A and PINOID directs auxin flux.
Cell 2007;130(6):1044-56.
2007: Benedict J Chambers; Per Grufman; Vanoohi Fredriksson; Kenth Andersson; Marjet Roseboom; Sandra Laban; Marcel Camps; Elisabeth Z Wolpert; Emmanuel J H J Wiertz; Rienk Offringa; Hans-Gustaf Ljunggren; Thorbald van Hall
Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination.
Cancer research 2007;67(18):8450-5.
2007: Martijn Bijker; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg
Design and development of synthetic peptide vaccines: past, present and future.
Expert review of vaccines 2007;6(4):591-603.
2007: Annechien J A Lambeck; Ninke Leffers; Baukje Nynke Hoogeboom; Wim Sluiter; Ineke Hamming; Harry Klip; Klaske A ten Hoor; Martha Esajas; Magda van Oven; Jan Wouter Drijfhout; Inge Platteel; Rienk Offringa; Harry Hollema; Kees Melief; Sjoerd H van der burg; Ate van der Zee; Toos Daemen; Hans W Nijman
P53-specific T cell responses in patients with malignant and benign ovarian tumors: implications for p53 based immunotherapy.
International journal of cancer. Journal international du cancer 2007;121(3):606-14.
2007: Sjoerd H van der burg; Sytse J Piersma; Annemieke de Jong; Jeanette M van der Hulst; Kitty M C Kwappenberg; Muriel van den Hende; Marij J P Welters; Jon van Rood; Gert Jan Fleuren; Cornelis J M Melief; Gemma G Kenter; Rienk Offringa
Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12087-92.
2007: Marij J P Welters; Martijn Bijker; Susan J F van den Eeden; Kees L M C Franken; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg
Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists.
Vaccine 2007;25(8):1379-89.
2007: Thorbald van Hall; Sandra Laban; Danijela Koppers-Lalic; Joachim Koch; Calin Precup; Patrick Asmawidjaja; Rienk Offringa; Emmanuel J H J Wiertz
The varicellovirus-encoded TAP inhibitor UL49.5 regulates the presentation of CTL epitopes by Qa-1b1.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):657-62.
2007: Sytse J Piersma; Ekaterina S. Jordanova; Mariëtte I E Van Poelgeest; Kitty M C Kwappenberg; Jeanette M van der Hulst; Jan Wouter Drijfhout; Cornelis J M Melief; Gemma G Kenter; Gert Jan Fleuren; Rienk Offringa; Sjoerd H van der burg
High number of intraepithelial CD8+ tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer.
Cancer research 2007;67(1):354-61.
2006: Rienk Offringa
Cancer. Cancer immunotherapy is more than a numbers game.
Science (New York, N.Y.) 2006;314(5796):68-9.
2006: Sjoerd H van der burg; Martijn Bijker; Marij J P Welters; Rienk Offringa; Cornelis J M Melief
Improved peptide vaccine strategies, creating synthetic artificial infections to maximize immune efficacy.
Advanced drug delivery reviews 2006;58(8):916-30.
2006: Jan H. Kessler; S A Bres-Vloemans; Peter van Veelen; Arnoud de Ru; Ivo Huijbers; Marcel Camps; Arend Mulder; Rienk Offringa; Jan Wouter Drijfhout; OC Leeksma; Ferry Ossendorp; Cornelis J M Melief
BCR-ABL fusion regions as a source of multiple leukemia-specific CD8+ T-cell epitopes.
Leukemia 2006;20(10):1738-50.
2006: Michael Bots; Rienk Offringa; Jan Paul Medema
Does the serpin PI-9 protect tumor cells?
Blood 2006;107(12):4974-5; author reply 4975.
2006: Thorbald van Hall; Elisabeth Z Wolpert; Peter van Veelen; Sandra Laban; Michael van der Veer; Marjet Roseboom; Sandra A Bres; Per Grufman; Arnoud de Ru; Hugo D Meiring; Annemieke de Jong; Kees L M C Franken; Antoinette Teixeira; Rob Valentijn; Jan Wouter Drijfhout; Frits Koning; Marcel Camps; Ferry Ossendorp; Klas Kärre; Hans-Gustaf Ljunggren; Cornelis J M Melief; Rienk Offringa
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants.
Nature medicine 2006;12(4):417-24.
2006: Marij J P Welters; Pauline van der Logt; Susan J F van den Eeden; Kitty M C Kwappenberg; Jan Wouter Drijfhout; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief; Sjoerd H van der burg; Rienk Offringa
Detection of human papillomavirus type 18 E6 and E7-specific CD4+ T-helper 1 immunity in relation to health versus disease.
International journal of cancer. Journal international du cancer 2006;118(4):950-6.
2006: Michael Bots; Liesbeth van Bostelen; Mirjam Tga Rademaker; Rienk Offringa; Jan Paul Medema
Serpins prevent granzyme-induced death in a species-specific manner.
Immunology and cell biology 2006;84(1):79-86.
2006: Mariëtte I E Van Poelgeest; Esther R Nijhuis; Kitty M C Kwappenberg; Ineke E Hamming; Jan Wouter Drijfhout; Gert Jan Fleuren; Ate G J van der Zee; Cornelis J M Melief; Gemma G Kenter; Hans W Nijman; Rienk Offringa; Sjoerd H van der burg
Distinct regulation and impact of type 1 T-cell immunity against HPV16 L1, E2 and E6 antigens during HPV16-induced cervical infection and neoplasia.
International journal of cancer. Journal international du cancer 2006;118(3):675-83.
2006: Federica Cavallo; Rienk Offringa; Sjoerd H van der burg; Guido Forni; Cornelis J M Melief
Vaccination for treatment and prevention of cancer in animal models.
Advances in immunology 2006;90():175-213.
2006: Jirí Friml; Philip N Benfey; Eva Benková; Malcolm Bennett; Thomas Berleth; Niko Geldner; Markus Grebe; Marcus G Heisler; Jan Hejátko; Gerd Jürgens; Thomas Laux; Keith Lindsey; Wolfgang Lukowitz; Christian Luschnig; Rienk Offringa; Ben Scheres; Ranjan Swarup; Ramón Torres-Ruiz; Dolf Weijers; Eva Zazímalová
Apical-basal polarity: why plant cells don't stand on their heads.
Trends in plant science 2006;11(1):12-4.
2005: Niels Smakman; Liesbeth M Veenendaal; Paulus van Diest; Reinhard Bos; Rienk Offringa; Inne H M Borel Rinkes; Onno Kranenburg
Dual effect of Kras(D12) knockdown on tumorigenesis: increased immune-mediated tumor clearance and abrogation of tumor malignancy.
Oncogene 2005;24(56):8338-42.
2005: Sylvie Fournel; Sébastien Wieckowski; Weimin Sun; Nathalie Trouche; Hélène Dumortier; Alberto Bianco; Olivier Chaloin; Mohammed Habib; Jean-Christophe Peter; Pascal Schneider; Bernard Vray; René E Toes; Rienk Offringa; Cornelis J M Melief; Johan Hoebeke; Gilles Guichard
C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L.
Nature chemical biology 2005;1(7):377-82.
2005: Dolf Weijers; Michael Sauer; Olivier Meurette; Jirí Friml; Karin Ljung; Göran Sandberg; Paul J J Hooykaas; Rienk Offringa
Maintenance of embryonic auxin distribution for apical-basal patterning by PIN-FORMED-dependent auxin transport in Arabidopsis.
The Plant cell 2005;17(9):2517-26.
2005: Annemieke Th den Boer; Geertje J D van Mierlo; Marieke F Fransen; Cornelis J M Melief; Rienk Offringa; René E M Toes
CD4+ T cells are able to promote tumor growth through inhibition of tumor-specific CD8+ T-cell responses in tumor-bearing hosts.
Cancer research 2005;65(15):6984-9.
2005: Mariëtte I E Van Poelgeest; Manon van Seters; Marc van Beurden; Kitty M C Kwappenberg; Claudia Heijmans-Antonissen; Jan Wouter Drijfhout; Cornelis J M Melief; Gemma G Kenter; Theo J M Helmerhorst; Rienk Offringa; Sjoerd H van der burg
Detection of human papillomavirus (HPV) 16-specific CD4+ T-cell immunity in patients with persistent HPV16-induced vulvar intraepithelial neoplasia in relation to clinical impact of imiquimod treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(14):5273-80.
2005: Rinke Bos; Suzanne van Duikeren; Thorbald van Hall; Patricia Kaaijk; Richard Taubert; Bruno Kyewski; Ludger Klein; Cornelis J M Melief; Rienk Offringa
Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire.
Cancer research 2005;65(14):6443-9.
2005: Hélène Dumortier; Geertje J D van Mierlo; Deirdre Egan; Willem van Ewijk; René E M Toes; Rienk Offringa; Cornelis J M Melief
Antigen presentation by an immature myeloid dendritic cell line does not cause CTL deletion in vivo, but generates CD8+ central memory-like T cells that can be rescued for full effector function.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):855-63.
2005: Maro H Sandel; Alisher R Dadabayev; Anand G Menon; Hans Morreau; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg; Connie M Janssen-Van Rhijn; N Geeske Ensink; R A E M Tollenaar; Cornelis J H van de Velde; Peter Kuppen
Prognostic value of tumor-infiltrating dendritic cells in colorectal cancer: role of maturation status and intratumoral localization.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2576-82.
2005: Rienk Offringa
Tumour immunology exploitation of the weapon of immune destruction for cancer therapy: taking aim before firing.
Current opinion in immunology 2005;17(2):159-62.
2005: Annemieke de Jong; Jeanette M van der Hulst; Gemma G Kenter; Jan Wouter Drijfhout; Kees L M C Franken; Pieter Vermeij; Rienk Offringa; Sjoerd H van der burg; Cornelis J M Melief
Rapid enrichment of human papillomavirus (HPV)-specific polyclonal T cell populations for adoptive immunotherapy of cervical cancer.
International journal of cancer. Journal international du cancer 2005;114(2):274-82.
2005: Michael Bots; Ingrid G M Kolfschoten; Sandra A Bres; Mirjam T G A Rademaker; Guido M de Roo; Margreet Krüse; Kees L M C Franken; Michael Hahne; Christopher J Froelich; Cornelis J M Melief; Rienk Offringa; Jan Paul Medema
SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity.
Blood 2005;105(3):1153-61.
2005: Rienk Offringa; Kitty Kwappenberg; Martijn Rabelink; Delphine Rea; Rob Hoeben
Adenoviral transduction of dendritic cells.
Methods in molecular medicine 2005;109():83-96.
2004: Marij J P Welters; Dmitri V Filippov; Susan J F van den Eeden; Kees L M C Franken; Jan Nouta; Rob Valentijn; Gijsbert A van der Marel; Herman S Overkleeft; Grayson Lipford; Rienk Offringa; Cornelis J M Melief; Jacques H van Boom; Sjoerd H van der burg; Jan Wouter Drijfhout
Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV16 E7 in the TC-1 mouse tumour model.
Vaccine 2004;23(3):305-11.
2004: Geertje J D van Mierlo; Zita F H M Boonman; Hélène M H Dumortier; Annemieke Th den Boer; Marieke F Fransen; Jan Nouta; Ellen I H van der Voort; Rienk Offringa; René E M Toes; Cornelis J M Melief
Activation of dendritic cells that cross-present tumor-derived antigen licenses CD8+ CTL to cause tumor eradication.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6753-9.
2004: Delphine Rea; Drake LaFace; Beth Hutchins; Kitty Kwappenberg; Cornelis J M Melief; Rob Hoeben; Rienk Offringa
Recombinant adenovirus-transduced human dendritic cells engineered to secrete interleukin-10 (IL-10) suppress Th1-type responses while selectively activating IL-10-producing CD4+ T cells.
Human immunology 2004;65(11):1344-55.
2004: Alisher R Dadabayev; Maro H Sandel; Anand G Menon; Hans Morreau; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg; Connie M Janssen-Van Rhijn; N Geeske Ensink; R A E M Tollenaar; Cornelis J H van de Velde; Peter Kuppen
Dendritic cells in colorectal cancer correlate with other tumor-infiltrating immune cells.
Cancer immunology, immunotherapy : CII 2004;53(11):978-86.
2004: Jirí Friml; Xiong Yang; Marta Michniewicz; Dolf Weijers; Ab Quint; Olaf Tietz; René Benjamins; Pieter B F Ouwerkerk; Karin Ljung; Göran Sandberg; Paul J J Hooykaas; Klaus Palme; Rienk Offringa
A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux.
Science (New York, N.Y.) 2004;306(5697):862-5.
2004: Annemieke de Jong; Mariëtte I E Van Poelgeest; Jeanette M van der Hulst; Jan Wouter Drijfhout; Gert Jan Fleuren; Cornelis J M Melief; Gemma G Kenter; Rienk Offringa; Sjoerd H van der burg
Human papillomavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2 and E6.
Cancer research 2004;64(15):5449-55.
2004: Matthias Hofmann; Markus P Radsak; Gerd Rechtsteiner; Katrin Wiemann; Marc Günder; Ursula Bien-Gräter; Rienk Offringa; René E M Toes; Hans-Georg Rammensee; Hansjörg Schild
T cell avidity determines the level of CTL activation.
European journal of immunology 2004;34(7):1798-806.
2004: Annemieke Th den Boer; Geertje J D van Mierlo; Marieke F Fransen; Cornelis J M Melief; Rienk Offringa; René E M Toes
The tumoricidal activity of memory CD8+ T cells is hampered by persistent systemic antigen, but full functional capacity is regained in an antigen-free environment.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6074-9.
2004: Lucy J C Smyth; Mariëtte I E Van Poelgeest; Emma J Davidson; Kitty M C Kwappenberg; Debbie Burt; Peter Sehr; Michael Pawlita; Stephen Man; Julian Hickling; Alison Fiander; Amanda Tristram; Henry C Kitchener; Rienk Offringa; Peter L Stern; Sjoerd H van der burg
Immunological responses in women with human papillomavirus type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):2954-61.
2004: Roger P M Sutmuller; Rienk Offringa; Cornelis J M Melief
Revival of the regulatory T cell: new targets for drug development.
Drug discovery today 2004;9(7):310-6.
2004: Mark W E J Fiers; Gerd Hause; Kim Boutilier; Eva Casamitjana-Martinez; Dolf Weijers; Rienk Offringa; Lonneke van der Geest; Michiel van Lookeren Campagne; Chun-Ming Liu
Mis-expression of the CLV3/ESR-like gene CLE19 in Arabidopsis leads to a consumption of root meristem.
Gene 2004;327(1):37-49.
2004: Zita F H M Boonman; Geertje J D van Mierlo; Marieke F Fransen; Kees L M C Franken; Rienk Offringa; Cornelis J M Melief; Martine J Jager; René E M Toes
Intraocular tumor antigen drains specifically to submandibular lymph nodes, resulting in an abortive cytotoxic T cell reaction.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1567-74.
2003: Dave L Roelen; Danita Schuurhuis; Daniëlle E M van den Boogaardt; Karin M Koekkoek; Paula P M C van Miert; Jolien J van Schip; Sandra Laban; Delphine Rea; Cees J M Melief; Rienk Offringa; Ferry Ossendorp; Frans H J Claas
Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells.
Transplantation 2003;76(11):1608-15.
2003: Dolf Weijers; Jan Piet Van Hamburg; Erwin Van Rijn; Paul J J Hooykaas; Rienk Offringa
Diphtheria toxin-mediated cell ablation reveals interregional communication during Arabidopsis seed development.
Plant physiology 2003;133(4):1882-92.
2003: Jirí Friml; Anne Vieten; Michael Sauer; Dolf Weijers; Heinz Schwarz; Thorsten Hamann; Rienk Offringa; Gerd Jürgens
Efflux-dependent auxin gradients establish the apical-basal axis of Arabidopsis.
Nature 2003;426(6963):147-53.
2003: Sjoerd H van der burg; Anand G Menon; Anke Redeker; Kees L M C Franken; Jan Wouter Drijfhout; R A E M Tollenaar; Henk H Hartgrink; Cornelis J H van de Velde; Peter Kuppen; Cornelis J M Melief; Rienk Offringa
Magnitude and polarization of P53-specific T-helper immunity in connection to leukocyte infiltration of colorectal tumors.
International journal of cancer. Journal international du cancer 2003;107(3):425-33.
2003: Peter J W Baldwin; Sjoerd H van der burg; Christopher M Boswell; Rienk Offringa; Julian Hickling; Jennifer Dobson; John St Clair Roberts; John A Latimer; Robin P Moseley; Nicholas Coleman; Margaret A Stanley; Jane C Sterling
Vaccinia-expressed human papillomavirus 16 and 18 e6 and e7 as a therapeutic vaccination for vulval and vaginal intraepithelial neoplasia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(14):5205-13.
2003: René Benjamins; Carlos S Galván Ampudia; Paul J J Hooykaas; Rienk Offringa
PINOID-mediated signaling involves calcium-binding proteins.
Plant physiology 2003;132(3):1623-30.
2003: Anand G Menon; Peter Kuppen; Sjoerd H van der burg; Rienk Offringa; Marie-Claude Bonnet; Bert I J Harinck; R A E M Tollenaar; Anke Redeker; Hein Putter; Philippe Moingeon; Hans Morreau; Cornelis J M Melief; Cornelis J H van de Velde
Safety of intravenous administration of a canarypox virus encoding the human wild-type p53 gene in colorectal cancer patients.
Cancer gene therapy 2003;10(7):509-17.
2003: Mary Morgan; Roger P M Sutmuller; Hendrik J Witteveen; Leonie van Duivenvoorde; Eric Zanelli; Cornelis J M Melief; Alies Snijders; Rienk Offringa; René R P De Vries; René E M Toes
CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis.
Arthritis and rheumatism 2003;48(5):1452-60.
2003: Matthias Theobald; Rienk Offringa
Anti-p53-directed immunotherapy of malignant disease.
Expert reviews in molecular medicine 2003;5(11):1-13.
2003: Andrea M Woltman; Sandra W van der Kooij; Paul J Coffer; Rienk Offringa; Mohamed R Daha; Cees van Kooten
Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression.
Blood 2003;101(4):1439-45.
2003: Marij J P Welters; Annemieke de Jong; Susan J F van den Eeden; Jeanette M van der Hulst; Kitty M C Kwappenberg; Sabrin Hassane; Kees L M C Franken; Jan Wouter Drijfhout; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg
Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter.
Cancer research 2003;63(3):636-41.
2003: Jan H. Kessler; Bregje Mommaas; Tuna Mutis; Ivo Huijbers; Debby Vissers; Willemien Benckhuijsen; G M Th Schreuder; Rienk Offringa; Els Goulmy; Cornelis J M Melief; Sjoerd H van der burg; Jan Wouter Drijfhout
Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides.
Human immunology 2003;64(2):245-55.
2002: Joop Wiegant; Thorbald van Hall; Marja van der Burg; Mario Colombo; Hans J Tanke; Rienk Offringa; Carla Rosenberg
Application of multicolor fluorescence in situ hybridization analysis for detection of cross-contamination and in vitro progression in commonly used murine tumor cell lines.
Cancer genetics and cytogenetics 2002;139(2):126-32.
2002: Sjoerd H van der burg; Annemieke de Jong; Marij J P Welters; Rienk Offringa; Cornelis J M Melief
The status of HPV16-specific T-cell reactivity in health and disease as a guide to HPV vaccine development.
Virus research 2002;89(2):275-84.
2002: Sander Zwaveling; Michel P M Vierboom; Sandra C Ferreira Mota; Jennifer A Hendriks; Marlies E Ooms; Roger P M Sutmuller; Kees L M C Franken; Hans W Nijman; Ferry Ossendorp; Sjoerd H van der burg; Rienk Offringa; Cornelis J M Melief
Antitumor efficacy of wild-type p53-specific CD4(+) T-helper cells.
Cancer research 2002;62(21):6187-93.
2002: Annemieke de Jong; T O'Neill; A Y Khan; Kitty M C Kwappenberg; S E Chisholm; N R Whittle; J A Dobson; L C Jack; J A St Clair Roberts; Rienk Offringa; Sjoerd H van der burg; Julian Hickling
Enhancement of human papillomavirus (HPV) type 16 E6 and E7-specific T-cell immunity in healthy volunteers through vaccination with TA-CIN, an HPV16 L2E7E6 fusion protein vaccine.
Vaccine 2002;20(29-30):3456-64.
2002: Cornelis J M Melief; Sjoerd H van der burg; René E M Toes; Ferry Ossendorp; Rienk Offringa
Effective therapeutic anticancer vaccines based on precision guiding of cytolytic T lymphocytes.
Immunological reviews 2002;188():177-82.
2002: Kim Boutilier; Rienk Offringa; Vijay K Sharma; Henk Kieft; Thérèse Ouellet; Lemin Zhang; Jiro Hattori; Chun-Ming Liu; André A M van Lammeren; Brian Miki; Jan B M Custers; Michiel van Lookeren Campagne
Ectopic expression of BABY BOOM triggers a conversion from vegetative to embryonic growth.
The Plant cell 2002;14(8):1737-49.
2002: Sander Zwaveling; Sandra C Ferreira Mota; Jan Nouta; Mark Johnson; Grayson Lipford; Rienk Offringa; Sjoerd H van der burg; Cornelis J M Melief
Established human papillomavirus type 16-expressing tumors are effectively eradicated following vaccination with long peptides.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):350-8.
2002: Sjoerd H van der burg; Anand G Menon; Anke Redeker; Marie-Claude Bonnet; Jan Wouter Drijfhout; R A E M Tollenaar; Cornelis J H van de Velde; Philippe Moingeon; Peter Kuppen; Rienk Offringa; Cornelis J M Melief
Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(5):1019-27.
2002: Geertje J D van Mierlo; Annemieke Th den Boer; Jan Paul Medema; Ellen I H van der Voort; Marieke F Fransen; Rienk Offringa; Cornelis J M Melief; René E M Toes
CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5561-6.
2002: Linda Diehl; Geertje J D van Mierlo; Annemieke Th den Boer; Ellen I H van der Voort; Marieke F Fransen; Liesbeth van Bostelen; Paul Krimpenfort; Cornelis J M Melief; Robert S Mittler; René E M Toes; Rienk Offringa
In vivo triggering through 4-1BB enables Th-independent priming of CTL in the presence of an intact CD28 costimulatory pathway.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):3755-62.
2002: Annemieke de Jong; Sjoerd H van der burg; Kitty M C Kwappenberg; Jeanette M van der Hulst; Kees L M C Franken; Annemieke Geluk; Krista E van Meijgaarden; Jan Wouter Drijfhout; Gemma G Kenter; Pieter Vermeij; Cornelis J M Melief; Rienk Offringa
Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects.
Cancer research 2002;62(2):472-9.
2002: Sander Zwaveling; Sjoerd H van der burg; Anand G Menon; Cornelis J M Melief; Rienk Offringa
Immunotherapy of cancer through targeting of the p53 tumor antigen.
Archivum immunologiae et therapiae experimentalis 2002;50(5):297-305.
2002: Lukas Heukamp; Thorbald van Hall; Ferry Ossendorp; Joy M Burchell; Cornelis J M Melief; Joyce Taylor-Papadimitriou; Rienk Offringa
Effective immunotherapy of cancer in MUC1-transgenic mice using clonal cytotoxic T lymphocytes directed against an immunodominant MUC1 epitope.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2002;25(1):46-56.
2001: Dolf Weijers; Niko Geldner; Rienk Offringa; Gerd Jürgens
Seed development: Early paternal gene activity in Arabidopsis.
Nature 2001;414(6865):709-10.
2001: Dolf Weijers; Marry E I Franke-van Dijk; R J Vencken; Ab Quint; Paul J J Hooykaas; Rienk Offringa
An Arabidopsis Minute-like phenotype caused by a semi-dominant mutation in a RIBOSOMAL PROTEIN S5 gene.
Development (Cambridge, England) 2001;128(21):4289-99.
2001: René Benjamins; Ab Quint; Dolf Weijers; Paul J J Hooykaas; Rienk Offringa
The PINOID protein kinase regulates organ development in Arabidopsis by enhancing polar auxin transport.
Development (Cambridge, England) 2001;128(20):4057-67.
2001: Jan Paul Medema; J de Jong; Lucy T C Peltenburg; Els Verdegaal; Arko Gorter; Sandra A Bres; Kees L M C Franken; Michael Hahne; Juan Pablo Albar; Cornelis J M Melief; Rienk Offringa
Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11515-20.
2001: Roger P M Sutmuller; Leonie van Duivenvoorde; A van Elsas; Schumacher Ton; M E Wildenberg; James P Allison; René E M Toes; Rienk Offringa; Cornelis J M Melief
Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses.
The Journal of experimental medicine 2001;194(6):823-32.
2001: Jan Paul Medema; Danita Schuurhuis; Delphine Rea; Joost van Tongeren; J de Jong; Sandra A Bres; Sandra Laban; René E M Toes; Mireille Toebes; Schumacher Ton; Bellinda A Bladergroen; Ferry Ossendorp; J Alain Kummer; Cornelis J M Melief; Rienk Offringa
Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells.
The Journal of experimental medicine 2001;194(5):657-67.
2001: Annemieke Th den Boer; Linda Diehl; Geertje J D van Mierlo; Ellen I H van der Voort; Marieke F Fransen; Paul Krimpenfort; Cornelis J M Melief; Rienk Offringa; René E M Toes
Longevity of antigen presentation and activation status of APC are decisive factors in the balance between CTL immunity versus tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2522-8.
2001: A van Elsas; Roger P M Sutmuller; Arthur A Hurwitz; J Ziskin; J Villasenor; Jan Paul Medema; W W Overwijk; N P Restifo; Cornelis J M Melief; Rienk Offringa; James P Allison
Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy.
The Journal of experimental medicine 2001;194(4):481-9.
2001: Sjoerd H van der burg; Kitty M C Kwappenberg; T O'Neill; RM Brandt; Cornelis J M Melief; Julian Hickling; Rienk Offringa
Pre-clinical safety and efficacy of TA-CIN, a recombinant HPV16 L2E6E7 fusion protein vaccine, in homologous and heterologous prime-boost regimens.
Vaccine 2001;19(27):3652-60.
2001: Delphine Rea; Menzo J E Havenga; M van Den Assem; Roger P M Sutmuller; Angelique A C Lemckert; Rob Hoeben; Abraham Bout; Cornelis J M Melief; Rienk Offringa
Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):5236-44.
2001: Delphine Rea; M E Johnson; Menzo J E Havenga; Cornelis J M Melief; Rienk Offringa
Strategies for improved antigen delivery into dendritic cells.
Trends in molecular medicine 2001;7(3):91-4.
2001: Sjoerd H van der burg; Maaike E Ressing; Kitty M C Kwappenberg; Annemieke de Jong; K Straathof; J de Jong; Annemieke Geluk; Krista E van Meijgaarden; Kees L M C Franken; Tom H M Ottenhoff; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief; Rienk Offringa
Natural T-helper immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: identification of 3 human leukocyte antigen class II-restricted epitopes.
International journal of cancer. Journal international du cancer 2001;91(5):612-8.
2001: S Heinzel; D Rea; Rienk Offringa; Graham Pawelec
The self peptide annexin II (208-223) presented by dendritic cells sensitizes autologous CD4+ T lymphocytes to recognize melanoma cells.
Cancer immunology, immunotherapy : CII 2001;49(12):671-8.
2001: Lukas Heukamp; Sjoerd H van der burg; J W Drijfhout; Cornelis J M Melief; Joyce Taylor-Papadimitriou; Rienk Offringa
Identification of three non-VNTR MUC1-derived HLA-A*0201-restricted T-cell epitopes that induce protective anti-tumor immunity in HLA-A2/K(b)-transgenic mice.
International journal of cancer. Journal international du cancer 2001;91(3):385-92.
2001: Sjoerd H van der burg; K de Cock; Anand G Menon; Kees L M C Franken; M Palmen; Anke Redeker; Jan Wouter Drijfhout; Peter Kuppen; Cornelis J H van de Velde; L Erdile; R A E M Tollenaar; Cornelis J M Melief; Rienk Offringa
Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer.
European journal of immunology 2001;31(1):146-55.
2001: Jan H. Kessler; Nico J Beekman; S A Bres-Vloemans; Pauline Verdijk; Peter van Veelen; A M Kloosterman-Joosten; Debby Vissers; GJ ten Bosch; Michel Kester; Alice J A M Sijts; Jan Wouter Drijfhout; Ferry Ossendorp; Rienk Offringa; Cornelis J M Melief
Efficient identification of novel HLA-A(*)0201-presented cytotoxic T lymphocyte epitopes in the widely expressed tumor antigen PRAME by proteasome-mediated digestion analysis.
The Journal of experimental medicine 2001;193(1):73-88.
2000: Marco W Schreurs; Andreas A O Eggert; Annemiek J de Boer; Joost L M Vissers; Thorbald van Hall; Rienk Offringa; Carl G Figdor; Gosse J Adema
Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model.
Cancer research 2000;60(24):6995-7001.
2000: Roger P M Sutmuller; Lucas R H M Schurmans; Leonie van Duivenvoorde; J A Tine; Ellen I H van der Voort; René E M Toes; Cornelis J M Melief; Martine J Jager; Rienk Offringa
Adoptive T cell immunotherapy of human uveal melanoma targeting gp100.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7308-15.
2000: Jeroen Van Bergen; Marcel Camps; Rienk Offringa; Cornelis J M Melief; Ferry Ossendorp; Frits Koning
Superior tumor protection induced by a cellular vaccine carrying a tumor-specific T helper epitope by genetic exchange of the class II-associated invariant chain peptide.
Cancer research 2000;60(22):6427-33.
2000: Michel P M Vierboom; Sander Zwaveling; Marlies E Ooms; G M Krietemeijer; Cornelis J M Melief; Rienk Offringa
High steady-state levels of p53 are not a prerequisite for tumor eradication by wild-type p53-specific cytotoxic T lymphocytes.
Cancer research 2000;60(19):5508-13.
2000: Rienk Offringa; Sjoerd H van der burg; Ferry Ossendorp; R E Toes; C J Melief
Design and evaluation of antigen-specific vaccination strategies against cancer.
Current opinion in immunology 2000;12(5):576-82.
2000: Ferry Ossendorp; René E M Toes; Rienk Offringa; Sjoerd H van der burg; Cornelis J M Melief
Importance of CD4(+) T helper cell responses in tumor immunity.
Immunology letters 2000;74(1):75-9.
2000: Alice J A M Sijts; Marcel Camps; Rienk Offringa; Cornelis J M Melief; Peter-M Kloetzel; Ferry Ossendorp
Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28.
The Journal of experimental medicine 2000;192(4):483-94.
2000: Thorbald van Hall; Jeroen Van Bergen; Peter van Veelen; M Kraakman; Lukas Heukamp; Frits Koning; Cornelis J M Melief; Ferry Ossendorp; Rienk Offringa
Identification of a novel tumor-specific CTL epitope presented by RMA, EL-4, and MBL-2 lymphomas reveals their common origin.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):869-77.
2000: Michel P M Vierboom; G M Bos; Marlies E Ooms; Rienk Offringa; Cornelis J M Melief
Cyclophosphamide enhances anti-tumor effect of wild-type p53-specific CTL.
International journal of cancer. Journal international du cancer 2000;87(2):253-60.
2000: Danita Schuurhuis; Sandra Laban; René E M Toes; Paola Ricciardi-Castagnoli; Monique J Kleijmeer; Ellen I H van der Voort; Delphine Rea; Rienk Offringa; H J Geuze; Cornelis J M Melief; Ferry Ossendorp
Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli.
The Journal of experimental medicine 2000;192(1):145-50.
2000: Rienk Offringa; Michel P M Vierboom; Sjoerd H van der burg; L Erdile; Cornelis J M Melief
p53: a potential target antigen for immunotherapy of cancer.
Annals of the New York Academy of Sciences 2000;910():223-33; discussion 233-6.
2000: Delphine Rea; Cees van Kooten; Krista E van Meijgaarden; T H Ottenhoff; Cornelis J M Melief; Rienk Offringa
Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10.
Blood 2000;95(10):3162-7.
2000: Maaike E Ressing; WJ van Driel; RM Brandt; Gemma G Kenter; J Hans De Jong; T Bauknecht; Gert Jan Fleuren; P Hoogerhout; Rienk Offringa; A Sette; E Celis; Howard Grey; Baptist J Trimbos; W Martin Kast; Cornelis J M Melief
Detection of T helper responses, but not of human papillomavirus-specific cytotoxic T lymphocyte responses, after peptide vaccination of patients with cervical carcinoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(2):255-66.
2000: Linda Diehl; Annemieke Th den Boer; Ellen I H van der Voort; Cornelis J M Melief; Rienk Offringa; René E M Toes
The role of CD40 in peripheral T cell tolerance and immunity.
Journal of molecular medicine (Berlin, Germany) 2000;78(7):363-71.
2000: Cornelis J M Melief; René E M Toes; Jan Paul Medema; Sjoerd H van der burg; Ferry Ossendorp; Rienk Offringa
Strategies for immunotherapy of cancer.
Advances in immunology 2000;75():235-82.
1999: Delphine Rea; Frederik H E Schagen; Rob Hoeben; M Mehtali; Menzo J E Havenga; René E M Toes; Cornelis J M Melief; Rienk Offringa
Adenoviruses activate human dendritic cells without polarization toward a T-helper type 1-inducing subset.
Journal of virology 1999;73(12):10245-53.
1999: Jan Paul Medema; J de Jong; Thorbald van Hall; Cornelis J M Melief; Rienk Offringa
Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein.
The Journal of experimental medicine 1999;190(7):1033-8.
1999: Linda Diehl; Annemieke Th den Boer; Stephen P Schoenberger; Ellen I H van der Voort; Schumacher Ton; Cornelis J M Melief; Rienk Offringa; René E M Toes
CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy.
Nature medicine 1999;5(7):774-9.
1999: WJ van Driel; Maaike E Ressing; Gemma G Kenter; RM Brandt; Eveline J T Krul; AB Van Rossum; Ed Schuuring; Rienk Offringa; T Bauknecht; A Tamm-Hermelink; P A van Dam; Gert Jan Fleuren; W Martin Kast; Cornelis J M Melief; J Baptist Trimbos
Vaccination with HPV16 peptides of patients with advanced cervical carcinoma: clinical evaluation of a phase I-II trial.
European journal of cancer (Oxford, England : 1990) 1999;35(6):946-52.
1999: Maaike E Ressing; J Hans De Jong; RM Brandt; Jan Wouter Drijfhout; Willemien Benckhuijsen; G M Th Schreuder; Rienk Offringa; W Martin Kast; Cornelis J M Melief
Differential binding of viral peptides to HLA-A2 alleles. Implications for human papillomavirus type 16 E7 peptide-based vaccination against cervical carcinoma.
European journal of immunology 1999;29(4):1292-303.
1999: René E M Toes; Ferry Ossendorp; Rienk Offringa; Cornelis J M Melief
CD4 T cells and their role in antitumor immune responses.
The Journal of experimental medicine 1999;189(5):753-6.
1999: Sjoerd H van der burg; Kitty M C Kwappenberg; Annemieke Geluk; M van der Kruk; Oscar Pontesilli; Egbert Hovenkamp; Kees L M C Franken; Krista E van Meijgaarden; Jan Wouter Drijfhout; Tom H M Ottenhoff; Cornelis J M Melief; Rienk Offringa
Identification of a conserved universal Th epitope in HIV-1 reverse transcriptase that is processed and presented to HIV-specific CD4+ T cells by at least four unrelated HLA-DR molecules.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):152-60.
1998: René E M Toes; Stephen P Schoenberger; Ellen I H van der Voort; Rienk Offringa; Cornelis J M Melief
CD40-CD40Ligand interactions and their role in cytotoxic T lymphocyte priming and anti-tumor immunity.
Seminars in immunology 1998;10(6):443-8.
1998: Stephen P Schoenberger; Ellen I H van der Voort; G M Krietemeijer; Rienk Offringa; Cornelis J M Melief; René E M Toes
Cross-priming of CTL responses in vivo does not require antigenic peptides in the endoplasmic reticulum of immunizing cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):3808-12.
1998: Stephen P Schoenberger; L E Jonges; R J Mooijaart; F Hartgers; René E M Toes; W Martin Kast; Cornelis J M Melief; Rienk Offringa
Efficient direct priming of tumor-specific cytotoxic T lymphocyte in vivo by an engineered APC.
Cancer research 1998;58(14):3094-100.
1998: Thorbald van Hall; N E van de Rhee; Stephen P Schoenberger; Michel P M Vierboom; Frank A W Verreck; Cornelis J M Melief; Rienk Offringa
Cryptic open reading frames in plasmid vector backbone sequences can provide highly immunogenic cytotoxic T-lymphocyte epitopes.
Cancer research 1998;58(14):3087-93.
1998: Stephen P Schoenberger; René E M Toes; Ellen I H van der Voort; Rienk Offringa; Cornelis J M Melief
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions.
Nature 1998;393(6684):480-3.
1998: René E M Toes; Ellen I H van der Voort; Stephen P Schoenberger; Jan Wouter Drijfhout; Louis van Bloois; G Storm; W Martin Kast; Rienk Offringa; Cornelis J M Melief
Enhancement of tumor outgrowth through CTL tolerization after peptide vaccination is avoided by peptide presentation on dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4449-56.
1998: ML De Bruijn; Danita Schuurhuis; Michel P M Vierboom; H Vermeulen; K A de Cock; Marlies E Ooms; Maaike E Ressing; Mireille Toebes; Kees L M C Franken; Jan Wouter Drijfhout; Tom H M Ottenhoff; Rienk Offringa; Cornelis J M Melief
Immunization with human papillomavirus type 16 (HPV16) oncoprotein-loaded dendritic cells as well as protein in adjuvant induces MHC class I-restricted protection to HPV16-induced tumor cells.
Cancer research 1998;58(4):724-31.
1998: Joke M M den Haan; LM Meadows; W Wang; Jos Pool; Els Blokland; T L Bishop; C Reinhardus; Jeffrey Shabanowitz; Rienk Offringa; Donald F Hunt; Victor H Engelhard; Els Goulmy
The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism.
Science (New York, N.Y.) 1998;279(5353):1054-7.
1997: René E M Toes; Rob Hoeben; Ellen I H van der Voort; Maaike E Ressing; A J van der Eb; Cornelis J M Melief; Rienk Offringa
Protective anti-tumor immunity induced by vaccination with recombinant adenoviruses encoding multiple tumor-associated cytotoxic T lymphocyte epitopes in a string-of-beads fashion.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14660-5.
1997: René E M Toes; Stephen P Schoenberger; Ellen I H van der Voort; W Martin Kast; Rob Hoeben; Cornelis J M Melief; Rienk Offringa
Activation or frustration of anti-tumor responses by T-cell-based immune modulation.
Seminars in immunology 1997;9(5):323-7.
1997: Michel P M Vierboom; H W Nijman; Rienk Offringa; Ellen I H van der Voort; Thorbald van Hall; L van den Broek; Gert Jan Fleuren; P Kenemans; W M Kast; Cornelis J M Melief
Tumor eradication by wild-type p53-specific cytotoxic T lymphocytes.
The Journal of experimental medicine 1997;186(5):695-704.
1997: Jeroen Van Bergen; Stephen P Schoenberger; Frank A W Verreck; R Amons; Rienk Offringa; Frits Koning
Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7499-502.
1997: E Ras; Sjoerd H van der burg; S T Zegveld; RM Brandt; Peter Kuppen; Rienk Offringa; S O Warnarr; C J van de Velde; Cornelis J M Melief
Identification of potential HLA-A *0201 restricted CTL epitopes derived from the epithelial cell adhesion molecule (Ep-CAM) and the carcinoembryonic antigen (CEA).
Human immunology 1997;53(1):81-9.
1996: Cornelis J M Melief; Rienk Offringa; René E M Toes; W Martin Kast
Peptide-based cancer vaccines.
Current opinion in immunology 1996;8(5):651-7.
1996: René E M Toes; R J Blom; Ellen I H van der Voort; Rienk Offringa; Cornelis J M Melief; W Martin Kast
Protective antitumor immunity induced by immunization with completely allogeneic tumor cells.
Cancer research 1996;56(16):3782-7.
1996: René E M Toes; Rienk Offringa; R J Blom; Cornelis J M Melief; W Martin Kast
Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7855-60.
1996: René E M Toes; W Martin Kast; R J Blom; S C Bakker; Rienk Offringa; Cornelis J M Melief
Efficient tumor eradication by adoptively transferred cytotoxic T-cell clones in allogeneic hosts.
International journal of cancer. Journal international du cancer 1996;66(5):686-91.
1996: René E M Toes; R J Blom; Rienk Offringa; W Martin Kast; Cornelis J M Melief
Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(10):3911-8.
1995: René E M Toes; M C Feltkamp; Maaike E Ressing; Michel P M Vierboom; R J Blom; RM Brandt; M Hartman; Rienk Offringa; Cornelis J M Melief; W Martin Kast
Cellular immunity against DNA tumour viruses: possibilities for peptide-based vaccines and immune escape.
Biochemical Society transactions 1995;23(3):692-6.
1995: René E M Toes; Rienk Offringa; R J Blom; RM Brandt; A J van der Eb; Cornelis J M Melief; W Martin Kast
An adenovirus type 5 early region 1B-encoded CTL epitope-mediating tumor eradication by CTL clones is down-modulated by an activated ras oncogene.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(7):3396-405.
1995: E Risseeuw; Rienk Offringa; M E Franke-van Dijk; Paul J J Hooykaas
Targeted recombination in plants using Agrobacterium coincides with additional rearrangements at the target locus.
The Plant journal : for cell and molecular biology 1995;7(1):109-19.
1994: M J de Groot; Rienk Offringa; J Groet; M P Does; Paul J J Hooykaas; P J van den Elzen
Non-recombinant background in gene targeting: illegitimate recombination between a hpt gene and a defective 5' deleted nptII gene can restore a Kmr phenotype in tobacco.
Plant molecular biology 1994;25(4):721-33.
1994: René E M Toes; Rienk Offringa; M C Feltkamp; M J Visseren; Stephen P Schoenberger; Cornelis J M Melief; W Martin Kast
Tumor rejection antigens and tumor specific cytotoxic T lymphocytes.
Behring Institute Mitteilungen 1994;(94):72-86.
1993: B M Hagmeyer; H König; Ingrid Herr; Rienk Offringa; Alt Zantema; Alex J van der Eb; Peter Herrlich; Peter Angel
Adenovirus E1A negatively and positively modulates transcription of AP-1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun.
The EMBO journal 1993;12(9):3559-72.
1993: Rienk Offringa; M E Franke-van Dijk; M J De Groot; P J van den Elzen; Paul J J Hooykaas
Nonreciprocal homologous recombination between Agrobacterium transferred DNA and a plant chromosomal locus.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(15):7346-50.
1992: M J de Groot; Rienk Offringa; M P Does; Paul J J Hooykaas; P J van den Elzen
Mechanisms of intermolecular homologous recombination in plants as studied with single- and double-stranded DNA molecules.
Nucleic acids research 1992;20(11):2785-94.
1991: M P Does; B M Dekker; M J de Groot; Rienk Offringa
A quick method to estimate the T-DNA copy number in transgenic plants at an early stage after transformation, using inverse PCR.
Plant molecular biology 1991;17(1):151-3.
1990: Hans van Dam; Rienk Offringa; I Meijer; B Stein; A M Smits; Peter Herrlich; Johannes L Bos; Alex J van der Eb
Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family.
Molecular and cellular biology 1990;10(11):5857-64.
1990: Rienk Offringa; M J de Groot; H J Haagsman; M P Does; P J van den Elzen; Paul J J Hooykaas
Extrachromosomal homologous recombination and gene targeting in plant cells after Agrobacterium mediated transformation.
The EMBO journal 1990;9(10):3077-84.
1990: Rienk Offringa; S Gebel; Hans van Dam; MC Timmers; A Smits; R Zwart; B Stein; Johannes L Bos; Alex J van der Eb; Peter Herrlich
A novel function of the transforming domain of E1a: repression of AP-1 activity.
Cell 1990;62(3):527-38.
1989: Hans van Dam; Rienk Offringa; A M Smits; Johannes L Bos; N C Jones; Alex J van der Eb
The repression of the growth factor-inducible genes JE, c-myc and stromelysin by adenovirus E1A is mediated by conserved region 1.
Oncogene 1989;4(10):1207-12.
1989: Alex J van der Eb; H T Timmers; Rienk Offringa; Alt Zantema; S J van den Heuvel; J A van Dam; J L Bos
Suppression of cellular gene activity in adenovirus-transformed cells.
Current topics in microbiology and immunology 1989;144():197-207.
1988: Rienk Offringa; A M Smits; A Houweling; Johannes L Bos; Alex J van der Eb
Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin.
Nucleic acids research 1988;16(23):10973-84.