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Anne O'Garra

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Jonathan M Pitt; Simon Blankley; Helen McShane; Anne O'Garra
Vaccination against tuberculosis: how can we better BCG?
Anne O'Garra
Brigitte Askonas (1923-2013).
Anne O'Garra; Paul S Redford; Robert J Wilkinson; Chloe I Bloom; Finlay W McNab; Matthew P R Berry
The immune response in tuberculosis.

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All Publications

2013: Jonathan M Pitt; Simon Blankley; Helen McShane; Anne O'Garra
Vaccination against tuberculosis: how can we better BCG?
Microbial pathogenesis 2013;58():2-16.
2013: Anne O'Garra
Brigitte Askonas (1923-2013).
Nature 2013;494(7435):37.
2013: Anne O'Garra; Paul S Redford; Robert J Wilkinson; Chloe I Bloom; Finlay W McNab; Matthew P R Berry
The immune response in tuberculosis.
Annual review of immunology 2013;31():475-527.
2012: Jonathan M Pitt; Paul S Redford; Evangelos Stavropoulos; Douglas B Young; Gregory J Bancroft; Amy M Beebe; Anne O'Garra
Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(8):4079-87.
2012: Jacques Banchereau; Virginia Pascual; Anne O'Garra
From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines.
Nature immunology 2012;13(10):925-31.
2012: Zoë Urry; Emmanuel Xystrakis; Anne O'Garra; David F Richards; Sejal Saglani; Zarin Brown; Andrew Bush; Emma S Chambers; Jillian Christensen; Sarah Dimeloe; Leona Gabryšová; Atul Gupta; Catherine M Hawrylowicz
The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells.
European journal of immunology 2012;42(10):2697-708.
2012: Anne O'Garra; Eric Pamer
Editorial overview.
Current opinion in immunology 2012;24(4):361-3.
2012: Ana Paula Freitas do Rosário; Tracey Lamb; Agathe Lang; Werner Muller; Anne O'Garra; Axel Roers; Philip Spence; Robin Stephens; Jean Langhorne
IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(3):1178-90.
2012: Dapeng Li; Xiao-Hua Li; Anne O'Garra; Jacques Banchereau; Nathalie Bosquet; Melissa Dullaers; Dorothée Duluc; Anne-Laure Flamar; Roger Le Grand; A Karolina Palucka; Gabrielle Romain; Gerard Zurawski; Sandra Zurawski; SangKon Oh
Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells.
The Journal of experimental medicine 2012;209(1):109-21.
2012: Chloe I Bloom; Damien Chaussabel; Christine Marian Graham; Marc Lipman; Tolu Oni; Virginia Pascual; Jose Rossello-Urgell; Fotini Rozakeas; Katalin A Wilkinson; Robert J Wilkinson; Zhaohui Xu; Jacques Banchereau; Matthew P R Berry; Anne O'Garra
Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy.
PloS one 2012;7(10):e46191.
2012: Jens Loebbermann; Anne O'Garra; Lydia Durant; Cecilia Johansson; Corinna Schnoeller; Martijn Schuijs; Nathan P Sweeney; Hannah Thornton; Peter J Openshaw
IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice.
PloS one 2012;7(2):e32371.
2012: Sonja Tattermusch; Graham P Taylor; Jacques Banchereau; Matthew P Berry; Damien Chaussabel; Finlay W McNab; Anne O'Garra; Jason A Skinner; Charles R M Bangham
Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy.
PLoS pathogens 2012;8(1):e1002480.
2011: Ruslan Medzhitov; Andrew L Mellor; David H Munn; Chen Dong; Leona Gabryšová; Dmitry Gabrilovich; Siamon Gordon; Göran K Hansson; Ashleigh Howes; Peter Libby; Ethan M Shevach; Ken Shortman; Giorgio Trinchieri; Anne O'Garra
Highlights of 10 years of immunology in Nature Reviews Immunology.
Nature reviews. Immunology 2011;11(10):693-702.
2011: A Wack; Peter Openshaw; Anne O'Garra
Contribution of cytokines to pathology and protection in virus infection.
Current opinion in virology 2011;1(3):184-95.
2011: Finlay W McNab; Tolu Oni; Katalin A Wilkinson; Robert J Wilkinson; Jacques Banchereau; Matthew P R Berry; Susannah A A Bloch; Damien Chaussabel; Christine Marian Graham; Onn M Kon; Anne O'Garra
Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis.
European journal of immunology 2011;41(7):1941-7.
2011: Leona Gabryšová; Jillian R Christensen; Xuemei Wu; adrien kissenpfennig; Bernard Malissen; Anne O'Garra
Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells.
European journal of immunology 2011;41(5):1242-8.
2011: P S Redford; P J Murray; Anne O'Garra
The role of IL-10 in immune regulation during M. tuberculosis infection.
Mucosal immunology 2011;4(3):261-70.
2011: Anne O'Garra; Leona Gabryšová; Hergen Spits
Quantitative events determine the differentiation and function of helper T cells.
Nature immunology 2011;12(4):288-94.
2011: Huei-Ting Yang; Yanyan Wang; Xixing Zhao; Ezana Demissie; Stamatia Papoutsopoulou; Agnes Mambole; Anne O'Garra; Michal F Tomczak; Susan E Erdman; James G Fox; Steven C Ley; Bruce H Horwitz
NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):1989-96.
2011: Finlay W McNab; Ricardo Rajsbaum; Jonathan P Stoye; Anne O'Garra
Tripartite-motif proteins and innate immune regulation.
Current opinion in immunology 2011;23(1):46-56.
2010: Matthew P R Berry; Christine Marian Graham; Finlay W McNab; Zhaohui Xu; Susannah A A Bloch; Tolu Oni; Katalin A Wilkinson; Romain Banchereau; Jason Skinner; Robert J Wilkinson; Charles Quinn; Derek Blankenship; Ranju Dhawan; John J Cush; Asuncion Mejias; Octavio Ramilo; Onn M Kon; Virginia Pascual; Jacques Banchereau; Damien Chaussabel; Anne O'Garra
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.
Nature 2010;466(7309):973-7.
2010: Paul S Redford; Andre Boonstra; Simon Read; Jonathan Pitt; Christine Marian Graham; Evangelos Stavropoulos; Gregory J Bancroft; Anne O'Garra
Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung.
European journal of immunology 2010;40(8):2200-10.
2010: Margarida Saraiva; Anne O'Garra
The regulation of IL-10 production by immune cells.
Nature reviews. Immunology 2010;10(3):170-81.
2009: George Kassiotis; Anne O'Garra
Establishing the follicular helper identity.
Immunity 2009;31(3):450-2.
2009: Anne O'Garra; Kenneth M Murphy
From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development.
Nature immunology 2009;10(9):929-32.
2009: Frank Kaiser; Dorthe Cook; Stamatia Papoutsopoulou; Ricardo Rajsbaum; Xuemei Wu; Huei-Ting Yang; Susan Grant; Paola Ricciardi-Castagnoli; Philip N Tsichlis; Steven C Ley; Anne O'Garra
TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells.
The Journal of experimental medicine 2009;206(9):1863-71.
2009: Margarida Saraiva; Jillian R Christensen; Marc Veldhoen; Theresa L Murphy; Kenneth M Murphy; Anne O'Garra
Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose.
Immunity 2009;31(2):209-19.
2009: Marc Veldhoen; Keiji Hirota; Jillian Christensen; Anne O'Garra; Brigitta Stockinger
Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells.
The Journal of experimental medicine 2009;206(1):43-9.
2008: Chyi-Song Hsieh; Steven E Macatonia; Catherine S Tripp; Stanley Wolf; Anne O'Garra; Kenneth M Murphy
Pillars article: development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. 1993. Science 260(5107): 547-549.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4437-9.
2008: Anne O'Garra; Franck J Barrat; Antonio G Castro; Alain Vicari; Catherine Hawrylowicz
Strategies for use of IL-10 or its antagonists in human disease.
Immunological reviews 2008;223():114-31.
2008: Anne O'Garra; Brigitta Stockinger; Marc Veldhoen
Differentiation of human T(H)-17 cells does require TGF-beta!
Nature immunology 2008;9(6):588-90.
2008: George Kassiotis; Anne O'Garra
Immunology. Immunity benefits from a little suppression.
Science (New York, N.Y.) 2008;320(5880):1168-9.
2008: Ricardo Rajsbaum; Jonathan Stoye; Anne O'Garra
Type I interferon-dependent and -independent expression of tripartite motif proteins in immune cells.
European journal of immunology 2008;38(3):619-30.
2008: Simon Rousseau; Matoula Papoutsopoulou; Antony Symons; Dorthe Cook; John M Lucocq; Alan R Prescott; Anne O'Garra; Steven C Ley; Philip Cohen
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages.
Journal of cell science 2008;121(Pt 2):149-54.
2007: Paulo Vieira; Anne O'Garra
Regula'ten' the gut.
Nature immunology 2007;8(9):905-7.
2007: Anne O'Garra; Paulo Vieira
T(H)1 cells control themselves by producing interleukin-10.
Nature reviews. Immunology 2007;7(6):425-8.
2007: Douglas Young; Anne O'Garra
Mycobacterium tuberculosis and its ability to resist immunity.
Novartis Foundation symposium 2007;281():169-77; discussion 177-80, 208-9.
2006: André Boonstra; Ricardo Rajsbaum; Mary Holman; Rute Marques; Carine Asselin-Paturel; João Pedro Pereira; Elizabeth E M Bates; Shizuo Akira; Paulo Vieira; Yong-Jun Liu; Giorgio Trinchieri; Anne O'Garra
Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7551-8.
2006: Maggie Neighbors; Suzanne B Hartley; Xiuling Xu; Antonio G Castro; Donna M Bouley; Anne O'Garra
Breakpoints in immunoregulation required for Th1 cells to induce diabetes.
European journal of immunology 2006;36(9):2315-23.
2006: Caroline A Rowland; Ganjana Lertmemongkolchai; Alison Bancroft; Ashraful Haque; M Stephen Lever; Kate F Griffin; Matthew C Jackson; Michelle Nelson; Anne O'Garra; Richard K Grencis; Gregory J Bancroft; Roman A Lukaszewski
Critical role of type 1 cytokines in controlling initial infection with Burkholderia mallei.
Infection and immunity 2006;74(9):5333-40.
2006: Anne_Marit Sponaas; Emma Tamsin Cadman; Cecile Voisine; Vicky Harrison; André Boonstra; Anne O'Garra; Jean Langhorne
Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells.
The Journal of experimental medicine 2006;203(6):1427-33.
2006: Stamatia Papoutsopoulou; Antony Symons; Tharsana Tharmalingham; Monica P Belich; Frank Kaiser; Dimitris Kioussis; Anne O'Garra; Victor L J Tybulewicz; Steven C Ley
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.
Nature immunology 2006;7(6):606-15.
2006: john shoemaker; Margarida Saraiva; Anne O'Garra
GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3470-9.
2006: Ashraful Haque; Anna Easton; Debbie Smith; Anne O'Garra; Nico van Rooijen; Ganjana Lertmemongkolchai; Richard Titball; Gregory J Bancroft
Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection.
The Journal of infectious diseases 2006;193(3):370-9.
2006: Emmanuel Xystrakis; Siddharth Kusumakar; Sandra Boswell; Emma Peek; Zoë Urry; David F Richards; Tonye Adikibi; Carol Pridgeon; Margaret Dallman; Tuck-Kay Loke; Douglas S Robinson; Franck J Barrat; Anne O'Garra; Paul Lavender; Tak H Lee; Christopher J Corrigan; Catherine M Hawrylowicz
Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients.
The Journal of clinical investigation 2006;116(1):146-55.
2005: Margarida Saraiva; Jillian R Christensen; Alla V Tsytsykova; Anne E Goldfeld; Steven C Ley; Dimitris Kioussis; Anne O'Garra
Identification of a macrophage-specific chromatin signature in the IL-10 locus.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):1041-6.
2005: Takaharu Okada; Mark J Miller; Ian Parker; Matthew F Krummel; Maggie Neighbors; Suzanne B Hartley; Anne O'Garra; Michael D Cahalan; Jason G Cyster
Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.
PLoS biology 2005;3(6):e150.
2005: Carine Asselin-Paturel; Géraldine Brizard; Karine Chemin; André Boonstra; Anne O'Garra; Alain P Vicari; Giorgio Trinchieri
Type I interferon dependence of plasmacytoid dendritic cell activation and migration.
The Journal of experimental medicine 2005;201(7):1157-67.
2005: Catherine M Hawrylowicz; Anne O'Garra
Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma.
Nature reviews. Immunology 2005;5(4):271-83.
2005: Thomas Barthlott; Halima Moncrieffe; Marc Veldhoen; Christopher J Atkins; Jillian Christensen; Anne O'Garra; Brigitta Stockinger
CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production.
International immunology 2005;17(3):279-88.
2004: Anne O'Garra; Trinchieri Giorgio
Are dendritic cells afraid of commitment?
Nature immunology 2004;5(12):1206-8.
2004: Anne O'Garra; Paulo Vieira; Paulo Vieira; Anne E Goldfeld
IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage.
The Journal of clinical investigation 2004;114(10):1372-8.
2004: Anne O'Garra; Paulo Vieira
Regulatory T cells and mechanisms of immune system control.
Nature medicine 2004;10(8):801-5.
2004: Paulo Vieira; Jillian R Christensen; Sophie Minaee; Emma J O'Neill; Franck J Barrat; André Boonstra; Thomas Barthlott; Brigitta Stockinger; David C Wraith; Anne O'Garra
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):5986-93.
2004: Anne O'Garra; Douglas Robinson
Development and function of T helper 1 cells.
Advances in immunology 2004;83():133-62.
2004: Alain P Vicari; Béatrice Vanbervliet; Catherine Massacrier; Claudia Chiodoni; Céline Vaure; Smina Aït-Yahia; Christophe Dercamp; Fabien Matsos; Olivier Reynard; Catherine Taverne; Philippe Merle; Mario P Colombo; Anne O'Garra; Giorgio Trinchieri; Christophe Caux
In vivo manipulation of dendritic cell migration and activation to elicit antitumour immunity.
Novartis Foundation symposium 2004;256():241-54; discussion 254-69.
2003: Yoh-ichi Seki; Hiromasa Inoue; Naoko Nagata; Katsuhiko Hayashi; Satoru Fukuyama; Koichiro Matsumoto; Okiru Komine; Shinjiro Hamano; Kunisuke Himeno; Kyoko Inagaki-Ohara; Nicholas Cacalano; Anne O'Garra; Tadahilo Oshida; Hirohisa Saito; James A Johnston; Akihiko Yoshimura; Masato Kubo
SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.
Nature medicine 2003;9(8):1047-54.
2003: Anne O'Garra; Paulo Vieira
Twenty-first century Foxp3.
Nature immunology 2003;4(4):304-6.
2003: Anne O'Garra; Franck J Barrat
In vitro generation of IL-10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by Th1- and Th2-inducing cytokines.
Immunology letters 2003;85(2):135-9.
2003: André Boonstra; Carine Asselin-Paturel; Michel Gilliet; Chad Crain; Giorgio Trinchieri; Yong-Jun Liu; Anne O'Garra
Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation.
The Journal of experimental medicine 2003;197(1):101-9.
2002: Alain P Vicari; Claudia Chiodoni; Céline Vaure; Smina Aït-Yahia; Christophe Dercamp; Fabien Matsos; Olivier Reynard; Catherine Taverne; Philippe Merle; Mario P Colombo; Anne O'Garra; Giorgio Trinchieri; Christophe Caux
Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody.
The Journal of experimental medicine 2002;196(4):541-9.
2002: Douglas S Robinson; Anne O'Garra
Further checkpoints in Th1 development.
Immunity 2002;16(6):755-8.
2002: Hirokazu Kurata; Hyun-Jun Lee; Terrill McClanahan; Robert L Coffman; Anne O'Garra; Naoko Arai
Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4538-45.
2002: Michel Gilliet; André Boonstra; Carine Paturel; Svetlana Antonenko; Xiu-Ling Xu; Giorgio Trinchieri; Anne O'Garra; Yong-Jun Liu
The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor.
The Journal of experimental medicine 2002;195(7):953-8.
2002: Franck J Barrat; Daniel J Cua; André Boonstra; David F Richards; Chad Crain; Huub F Savelkoul; Rene de Waal Malefyt; Robert L Coffman; Catherine M Hawrylowicz; Anne O'Garra
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.
The Journal of experimental medicine 2002;195(5):603-16.
2002: Valerie Julia; Edith M Hessel; Laurent Malherbe; Nicolas Glaichenhaus; Anne O'Garra; Robert L Coffman
A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure.
Immunity 2002;16(2):271-83.
2002: Victoria L Heath; H Kurata; HJ Lee; N Arai; Anne O'Garra
Checkpoints in the regulation of T helper 1 responses.
Current topics in microbiology and immunology 2002;266():23-39.
2001: Carine Asselin-Paturel; A Boonstra; Marc Dalod; Isabelle Durand; N Yessaad; Colette Dezutter-Dambuyant; Alain P Vicari; Anne O'Garra; Christine A Biron; Francine Brière; Giorgio Trinchieri
Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology.
Nature immunology 2001;2(12):1144-50.
2001: André Boonstra; Franck J Barrat; Chad Crain; Victoria L Heath; H F Savelkoul; Anne O'Garra
1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):4974-80.
2001: Maggie Neighbors; X Xu; Franck J Barrat; S R Ruuls; Tatyana Churakova; R Debets; J. Fernando Bazan; Robert A Kastelein; JS Abrams; Anne O'Garra
A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production.
The Journal of experimental medicine 2001;194(3):343-54.
2001: Stephen W Chensue; Nicholas W Lukacs; TY Yang; Xiaozhou Shang; Kirsten A Frait; Steven Kunkel; Ted T Kung; Maria T Wiekowski; Joseph A Hedrick; Donald N Cook; Alessandra Zingoni; Satwant K Narula; Albert Zlotnik; Franck J Barrat; Anne O'Garra; M Napolitano; sergio lira
Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice.
The Journal of experimental medicine 2001;193(5):573-84.
2001: Joan K Brieland; Craig Jackson; Frederick Menzel; David Loebenberg; Anthony Cacciapuoti; Judith Halpern; S Hurst; Tony Muchamuel; R Debets; Robert A Kastelein; Tatyana Churakova; Jon Abrams; Roberta S Hare; Anne O'Garra
Cytokine networking in lungs of immunocompetent mice in response to inhaled Aspergillus fumigatus.
Infection and immunity 2001;69(3):1554-60.
2001: Kevin W Moore; Rene de Waal Malefyt; Robert L Coffman; Anne O'Garra
Interleukin-10 and the interleukin-10 receptor.
Annual review of immunology 2001;19():683-765.
2000: N Takemoto; Yumiko Kamogawa; H Jun Lee; Hirokazu Kurata; K i Arai; Anne O'Garra; Naoko Arai; Shoichiro Miyatake
Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6687-91.
2000: Joan K Brieland; Craig Jackson; S Hurst; David Loebenberg; Tony Muchamuel; R Debets; Robert A Kastelein; Tatyana Churakova; Jon Abrams; Roberta S Hare; Anne O'Garra
Immunomodulatory role of endogenous interleukin-18 in gamma interferon-mediated resolution of replicative Legionella pneumophila lung infection.
Infection and immunity 2000;68(12):6567-73.
2000: Antonio G Castro; Maggie Neighbors; S D Hurst; F Zonin; R A Silva; E Murphy; Yong-Jun Liu; Anne O'Garra
Anti-interleukin 10 receptor monoclonal antibody is an adjuvant for T helper cell type 1 responses to soluble antigen only in the presence of lipopolysaccharide.
The Journal of experimental medicine 2000;192(10):1529-34.
2000: R Debets; Jacqueline Timans; T Churakowa; Sandra Zurawski; Rene de Waal Malefyt; Kevin W Moore; JS Abrams; Anne O'Garra; J. Fernando Bazan; Robert A Kastelein
IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4950-6.
2000: Victoria L Heath; E E Murphy; Chad Crain; Michael G Tomlinson; Anne O'Garra
TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression.
European journal of immunology 2000;30(9):2639-49.
2000: Hyun-Jun Lee; N Takemoto; Hirokazu Kurata; Yumiko Kamogawa; Shoichiro Miyatake; Anne O'Garra; Naoko Arai
GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells.
The Journal of experimental medicine 2000;192(1):105-15.
2000: Victoria L Heath; L Showe; Chad Crain; Franck J Barrat; Giorgio Trinchieri; Anne O'Garra
Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):2861-5.
1999: H Kurata; HJ Lee; Anne O'Garra; N Arai
Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells.
Immunity 1999;11(6):677-88.
1999: Antonio G Castro; T M Hauser; BG Cocks; Jon Abrams; Sandra Zurawski; Tatyana Churakova; F Zonin; D Robinson; Stuart G Tangye; Gregorio Aversa; Kim E Nichols; Jan E de Vries; Lewis L Lanier; Anne O'Garra
Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):5860-70.
1999: D Chen; Victoria L Heath; Anne O'Garra; J Johnston; M McMahon
Sustained activation of the raf-MEK-ERK pathway elicits cytokine unresponsiveness in T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):5796-805.
1999: JC Grimaldi; N X Yu; G Grunig; Brian W P Seymour; Françoise Cottrez; D S Robinson; N Hosken; W G Ferlin; X Wu; Hortensia Soto; Anne O'Garra; MC Howard; Robert L Coffman
Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3).
Journal of leukocyte biology 1999;65(6):846-53.
1999: I A Ferber; HJ Lee; F Zonin; Victoria L Heath; A Mui; N Arai; Anne O'Garra
GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels.
Clinical immunology (Orlando, Fla.) 1999;91(2):134-44.
1999: N Arai; HJ Lee; I Ferber; H Kurata; Anne O'Garra
Multiple levels of regulation of Th2 cytokine gene expression.
Cold Spring Harbor symposia on quantitative biology 1999;64():589-98.
1999: Robert L Coffman; S Mocci; Anne O'Garra
The stability and reversibility of Th1 and Th2 populations.
Current topics in microbiology and immunology 1999;238():1-12.
1998: Yumiko Kamogawa; Hyun-Jun Lee; J A Johnston; M McMahon; Anne O'Garra; Naoko Arai
A conditionally active form of STAT6 can mimic certain effects of IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(3):1074-7.
1998: Alessandra Zingoni; Hortensia Soto; Joseph A Hedrick; Antonella Stoppacciaro; C T Storlazzi; Francesco Sinigaglia; Daniele D'Ambrosio; Anne O'Garra; D Robinson; M Rocchi; Angela Santoni; Albert Zlotnik; M Napolitano
The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):547-51.
1998: Anne O'Garra
Cytokines induce the development of functionally heterogeneous T helper cell subsets.
Immunity 1998;8(3):275-83.
1998: Hyun-Jun Lee; Anne O'Garra; K i Arai; Naoko Arai
Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for a GATA-binding protein.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2343-52.
1998: K Shibuya; D Robinson; F Zonin; S B Hartley; S E Macatonia; C Somoza; C A Hunter; K M Murphy; Anne O'Garra
IL-1 alpha and TNF-alpha are required for IL-12-induced development of Th1 cells producing high levels of IFN-gamma in BALB/c but not C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1708-16.
1997: Hervé Groux; Anne O'Garra; Mike E Bigler; M Rouleau; Svetlana Antonenko; Jan E de Vries; Maria-Grazia Roncarolo
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.
Nature 1997;389(6652):737-42.
1997: D Robinson; K Shibuya; A Mui; F Zonin; E Murphy; T Sana; S B Hartley; Satish Menon; Robert A Kastelein; J. Fernando Bazan; Anne O'Garra
IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.
Immunity 1997;7(4):571-81.
1996: A P Vicari; S Mocci; Peter J M Openshaw; Anne O'Garra; Albert Zlotnik
Mouse gamma delta TCR+NK1.1+ thymocytes specifically produce interleukin-4, are major histocompatibility complex class I independent, and are developmentally related to alpha beta TCR+NK1.1+ thymocytes.
European journal of immunology 1996;26(7):1424-9.
1996: E Murphy; K Shibuya; N Hosken; Peter J M Openshaw; V Maino; K Davis; K Murphy; Anne O'Garra
Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.
The Journal of experimental medicine 1996;183(3):901-13.
1996: C A Wenner; M L Güler; S E Macatonia; Anne O'Garra; Kenneth M Murphy
Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(4):1442-7.
1995: N A Hosken; K Shibuya; A W Heath; Kenneth M Murphy; Anne O'Garra
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.
The Journal of experimental medicine 1995;182(5):1579-84.
1995: Peter J M Openshaw; E E Murphy; N A Hosken; V Maino; K Davis; K Murphy; Anne O'Garra
Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.
The Journal of experimental medicine 1995;182(5):1357-67.
1995: Anne O'Garra; N Hosken; S Macatonia; C A Wenner; K Murphy
The role of macrophage- and dendritic cell-derived IL12 in Th1 phenotype development.
Research in immunology 1995;146(7-8):466-72.
1995: S E Macatonia; N A Hosken; M Litton; P Vieira; C S Hsieh; J A Culpepper; M Wysocka; G Trinchieri; Kenneth M Murphy; Anne O'Garra
Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5071-9.
1995: C S Hsieh; S E Macatonia; Anne O'Garra; Kenneth M Murphy
T cell genetic background determines default T helper phenotype development in vitro.
The Journal of experimental medicine 1995;181(2):713-21.
1994: E E Murphy; G Terres; S E Macatonia; C S Hsieh; J Mattson; Lewis L Lanier; M Wysocka; G Trinchieri; K Murphy; Anne O'Garra
B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.
The Journal of experimental medicine 1994;180(1):223-31.
1993: Anne O'Garra; K Murphy
T-cell subsets in autoimmunity.
Current opinion in immunology 1993;5(6):880-6.
1993: Anne O'Garra; S E Macatonia; C S Hsieh; Kenneth M Murphy
Regulatory role of IL4 and other cytokines in T helper cell development in an alpha beta TCR transgenic mouse system.
Research in immunology 1993;144(8):620-5.
1993: S E Macatonia; C S Hsieh; Kenneth M Murphy; Anne O'Garra
Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from alpha beta TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent.
International immunology 1993;5(9):1119-28.
1993: S E Macatonia; Timothy Doherty; S C Knight; Anne O'Garra
Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(9):3755-65.
1993: C S Hsieh; S E Macatonia; C S Tripp; Stanley Wolf; Anne O'Garra; Kenneth M Murphy
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.
Science (New York, N.Y.) 1993;260(5107):547-9.
1993: C S Hsieh; S E Macatonia; Anne O'Garra; Kenneth M Murphy
Pathogen-induced Th1 phenotype development in CD4+ alpha beta-TCR transgenic T cells is macrophage dependent.
International immunology 1993;5(4):371-82.
1993: Kevin W Moore; Anne O'Garra; Rene de Waal Malefyt; P Vieira; TR Mosmann
Interleukin-10.
Annual review of immunology 1993;11():165-90.
1992: C S Hsieh; A B Heimberger; J S Gold; Anne O'Garra; Kenneth M Murphy
Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6065-9.
1992: M Howard; Anne O'Garra
Biological properties of interleukin 10.
Immunology today 1992;13(6):198-200.
1992: Anne O'Garra; P Vieira
Polymerase chain reaction for detection of cytokine gene expression.
Current opinion in immunology 1992;4(2):211-5.
1992: Anne O'Garra; R Chang; N Go; R Hastings; G Haughton; M Howard
Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10.
European journal of immunology 1992;22(3):711-7.
1991: D F Fiorentino; Albert Zlotnik; TR Mosmann; M Howard; Anne O'Garra
IL-10 inhibits cytokine production by activated macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3815-22.
1991: TR Mosmann; J H Schumacher; N F Street; R Budd; Anne O'Garra; T A Fong; M W Bond; Kevin W Moore; A Sher; D F Fiorentino
Diversity of cytokine synthesis and function of mouse CD4+ T cells.
Immunological reviews 1991;123():209-29.
1991: D F Fiorentino; Albert Zlotnik; P Vieira; TR Mosmann; M Howard; Kevin W Moore; Anne O'Garra
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(10):3444-51.
1990: T Suda; Anne O'Garra; I MacNeil; M Fischer; M W Bond; Albert Zlotnik
Identification of a novel thymocyte growth-promoting factor derived from B cell lymphomas.
Cellular immunology 1990;129(1):228-40.
1990: Anne O'Garra; G Stapleton; V Dhar; M Pearce; J Schumacher; H Rugo; D Barbis; A Stall; J Cupp; K Moore
Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10.
International immunology 1990;2(9):821-32.
1989: Anne O'Garra; D Barbis; J Wu; Philip D Hodgkin; J Abrams; M Howard
The BCL1 B lymphoma responds to IL-4, IL-5, and GM-CSF.
Cellular immunology 1989;123(1):189-200.
1989: Anne O'Garra
Interleukins and the immune system 2.
Lancet 1989;1(8645):1003-5.
1989: Anne O'Garra
Interleukins and the immune system 1.
Lancet 1989;1(8644):943-7.
1989: Anne O'Garra; D Barbis; N Harada; F Lee; M Howard
Constitutive production of lymphokines by cloned murine B-cell lymphomas--CH12 B lymphoma produces interleukin-4.
The Journal of molecular and cellular immunology : JMCI 1989;4(3):149-58; discussion 158-9.
1988: J H Schumacher; Anne O'Garra; B Shrader; A van Kimmenade; M W Bond; TR Mosmann; Robert L Coffman
The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(5):1576-81.
1988: Philip D Hodgkin; M W Bond; Anne O'Garra; G Frank; F Lee; Robert L Coffman; Albert Zlotnik; M Howard
Identification of IL-6 as a T cell-derived factor that enhances the proliferative response of thymocytes to IL-4 and phorbol myristate acetate.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):151-7.