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Manuel Benito

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Almudena Gómez-Hernández; Liliana Perdomo; Oscar Escribano; Manuel Benito
[Role of brown and perivascular adipose tissue in vascular complications due to obesity].
Almudena Gómez-Hernández; Liliana Perdomo; Oscar Escribano; Manuel Benito
[Role of white adipose tissue in vascular complications due to obesity].
Alberto Bartolome; Carlos Guillen; Manuel Benito
Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death.

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All Publications

2013: Almudena Gómez-Hernández; Liliana Perdomo; Oscar Escribano; Manuel Benito
[Role of brown and perivascular adipose tissue in vascular complications due to obesity].
Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis 2013;25(1):36-44.
2013: Almudena Gómez-Hernández; Liliana Perdomo; Oscar Escribano; Manuel Benito
[Role of white adipose tissue in vascular complications due to obesity].
Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis 2013;25(1):27-35.
2012: Alberto Bartolome; Carlos Guillen; Manuel Benito
Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death.
Autophagy 2012;8(12):1757-68.
2012: Almudena Gómez-Hernández; Vicente Lahera; Yolanda F Otero; Victoria Cachofeiro; Natalia de Las Heras; Oscar Escribano; Manuel Benito
Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction.
Endocrinology 2012;153(3):1242-55.
2012: Tamara Fernández-Marcelo; Ana Gómez; Jacqueline Head; Susana Hernández; Florentino Hernando; Jose A López-Asenjo; Alberto Moran; Irene Pascua; Andrés Sánchez-Pernaute; Antonio-Jose Torres; Manuel Benito; Carmen de Juan; Pilar Iniesta
Differential expression of senescence and cell death factors in non-small cell lung and colorectal tumors showing telomere attrition.
Oncology 2012;82(3):153-64.
2011: Manuel Benito
Tissue-specificity of insulin action and resistance.
Archives of physiology and biochemistry 2011;117(3):96-104.
2011: Manuel Benito
Tissue specificity on insulin action and resistance: past to recent mechanisms.
Acta physiologica (Oxford, England) 2011;201(3):297-312.
2010: Alberto Bartolomé; Carlos Guillén; Manuel Benito
Role of the TSC1-TSC2 complex in the integration of insulin and glucose signaling involved in pancreatic beta-cell proliferation.
Endocrinology 2010;151(7):3084-94.
2010: Paloma Ortega; Alberto Moran; Tamara Fernandez-Marcelo; Carmen de Juan; Cristina Frias; José-Antonio Lopez-Asenjo; Andrés Sanchez-Pernaute; Antonio Torres; Eduardo Diaz-Rubio; Pilar Iniesta; Manuel Benito
MMP-7 and SGCE as distinctive molecular factors in sporadic colorectal cancers from the mutator phenotype pathway.
International journal of oncology 2010;36(5):1209-15.
2010: Alvaro Gutiérrez-Uzquiza; María Arechederra; Isabel Molina; Rocío Baños; Vera Maia; Manuel Benito; Carmen Guerrero; Almudena Porras
C3G down-regulates p38 MAPK activity in response to stress by Rap-1 independent mechanisms: involvement in cell death.
Cellular signalling 2010;22(3):533-42.
2008: Carlos Guillen; A Bartolomé; C Nevado; Manuel Benito
Biphasic effect of insulin on beta cell apoptosis depending on glucose deprivation.
FEBS letters 2008;582(28):3855-60.
2008: Agueda González-Rodriguez; Carmen Nevado; Fernando Escrivá; Giorgio Sesti; cristina Rondinone; Manuel Benito; Angela M Valverde
PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(2):G338-47.
2008: Cristina Frías; Cristina García-Aranda; Carmen de Juan; Alberto Moran; Paloma Ortega; Ana Gómez; Florentino Hernando; Jose-Antonio López-Asenjo; Antonio-José Torres; Manuel Benito; Pilar Iniesta
Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2008;60(3):416-25.
2008: Paloma Ortega; Alberto Moran; Carmen de Juan; Cristina Frías; Susana Hernández; Jose-Antonio López-Asenjo; Andrés Sánchez-Pernaute; Antonio Torres; Pilar Iniesta; Manuel Benito
Differential Wnt pathway gene expression and E-cadherin truncation in sporadic colorectal cancers with and without microsatellite instability.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(4):995-1001.
2007: Susana Zuluaga; Alvaro Gutiérrez-Uzquiza; Paloma Bragado; Alberto Alvarez-Barrientos; Manuel Benito; Angel R Nebreda; Almudena Porras
p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum.
FEBS letters 2007;581(20):3819-25.
2007: Agueda González-Rodriguez; Oscar Escribano; Javier Alba; cristina Rondinone; Manuel Benito; Angela M Valverde
Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes.
Journal of cellular physiology 2007;212(1):76-88.
2007: Francisco-Javier Rodríguez-Jiménez; Trinidad Caldés; Pilar Iniesta; Jose Antonio Vidart; José López Garcia-Asenjo; Manuel Benito
Overexpression of SPARC protein contrasts with its transcriptional silencing by aberrant hypermethylation of SPARC CpG-rich region in endometrial carcinoma.
Oncology reports 2007;17(6):1301-7.
2007: Oscar Escribano; Mónica Arribas; Angela M Valverde; Manuel Benito
IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes.
Molecular and cellular endocrinology 2007;268(1-2):1-9.
2007: Agueda Gonzalez-Rodriguez; Jill E Clampit; Oscar Escribano; Manuel Benito; cristina Rondinone; Angela M Valverde
Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.
Endocrinology 2007;148(2):594-608.
2007: Marta de Mingo; Alberto Moran; Andrés Sánchez-Pernaute; Pilar Iniesta; Luis Díez-Valladares; Elia Pérez-Aguirre; Carmen de Juan; Cristina García-Aranda; Antonio Díaz-López; Alejandra García-Botella; Esteban Martín-Antona; Manuel Benito; Antonio Torres; Jose L Balibrea
Expression of MMP-9 and TIMP-1 as prognostic markers in gastric carcinoma.
Hepato-gastroenterology 2007;54(73):315-9.
2007: Pilar Iniesta; Alberto Moran; Carmen de Juan; Ana Gómez; Florentino Hernando; Cristina García-Aranda; Cristina Frías; Antonio Díaz-López; Francisco-Javier Rodríguez-Jiménez; Jose L Balibrea; Manuel Benito
Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer.
Oncology reports 2007;17(1):217-23.
2007: Susana Zuluaga; Alberto Alvarez-Barrientos; Alvaro Gutiérrez-Uzquiza; Manuel Benito; Angel R Nebreda; Almudena Porras
Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1.
Cellular signalling 2007;19(1):62-74.
2006: Carmen Nevado; Angela M Valverde; Manuel Benito
Role of insulin receptor in the regulation of glucose uptake in neonatal hepatocytes.
Endocrinology 2006;147(8):3709-18.
2006: Manuel Benito; Eduardo Díaz-Rubio
Molecular biology in colorectal cancer.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2006;8(6):391-8.
2006: Carlos Guillen; Paloma Navarro; M Robledo; Angela M Valverde; Manuel Benito
Differential mitogenic signaling in insulin receptor-deficient fetal pancreatic beta-cells.
Endocrinology 2006;147(4):1959-68.
2006: Cristina Garcia-Aranda; Carmen de Juan; Antonio Diaz-Lopez; Andres Sanchez-Pernaute; Antonio-Jose Torres; Eduardo Diaz-Rubio; Jose L Balibrea; Manuel Benito; Pilar Iniesta
Correlations of telomere length, telomerase activity, and telomeric-repeat binding factor 1 expression in colorectal carcinoma.
Cancer 2006;106(3):541-51.
2005: Antonio Díaz-López; Carmen Rivas; Pilar Iniesta; Alberto Moran; Cristina García-Aranda; D Megías; Andrés Sánchez-Pernaute; Antonio Torres; Eduardo Díaz-Rubio; Manuel Benito; Carmen de Juan
Characterization of MDGA1, a novel human glycosylphosphatidylinositol-anchored protein localized in lipid rafts.
Experimental cell research 2005;307(1):91-9.
2005: Alberto Moran; Pilar Iniesta; Carmen de Juan; Cristina García-Aranda; Antonio Díaz-López; Manuel Benito
Impairment of stromelysin-1 transcriptional activity by promoter mutations in high microsatellite instability colorectal tumors.
Cancer research 2005;65(9):3811-4.
2005: Andrés Sánchez-Pernaute; Elia Pérez-Aguirre; Francisca Cerdán; Pilar Iniesta; Luis Díez-Valladares; Carmen de Juan; Alberto Moran; Alejandra García-Botella; Cristina García-Aranda; Manuel Benito; Antonio-Jose Torres; Jose L Balibrea
Overexpression of c-myc and loss of heterozygosity on 2p, 3p, 5q, 17p and 18q in sporadic colorectal carcinoma.
Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva 2005;97(3):169-78.
2005: Angela M Valverde; Manuel Benito
The brown adipose cell: a unique model for understanding the molecular mechanism of insulin resistance.
Mini reviews in medicinal chemistry 2005;5(3):269-78.
2005: Alberto Moran; Pilar Iniesta; Cristina García-Aranda; Carmen de Juan; Antonio Díaz-López; Andrés Sánchez-Pernaute; Antonio-Jose Torres; Eduardo Díaz-Rubio; Jose L Balibrea; Manuel Benito
Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer.
Oncology reports 2005;13(1):115-20.
2004: Angela M Valverde; Isabel Fabregat; Deborah J Burks; Morris F White; Manuel Benito
IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes.
Hepatology (Baltimore, Md.) 2004;40(6):1285-94.
2004: Angela M Valverde; Cecilia Mur; Michael Brownlee; Manuel Benito
Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.
Molecular biology of the cell 2004;15(11):5101-17.
2004: Trinidad Caldés; Javier Godino; Ana Sanchez; Cesar Corbacho; Miguel de la Hoya; Jose Lopez Asenjo; Carmen Saez; Julian Sanz; Manuel Benito; Santiago Ramon Y Cajal; Eduardo Diaz-Rubio
Immunohistochemistry and microsatellite instability testing for selecting MLH1, MSH2 and MSH6 mutation carriers in hereditary non-polyposis colorectal cancer.
Oncology reports 2004;12(3):621-9.
2004: Pilar Iniesta; Rosa González-Quevedo; Alberto Moran; Cristina García-Aranda; Carmen de Juan; Andrés Sánchez-Pernaute; Antonio Torres; Eduardo Díaz-Rubio; Jose L Balibrea; Manuel Benito
Relationship between 3p deletions and telomerase activity in non-small-cell lung cancer: prognostic implications.
British journal of cancer 2004;90(10):1983-8.
2004: Rosa González-Quevedo; Cristina García-Aranda; Alberto Moran; Carmen de Juan; Andrés Sánchez-Pernaute; Antonio Torres; Eduardo Díaz-Rubio; Jose L Balibrea; Manuel Benito; Pilar Iniesta
Differential impact of p16 inactivation by promoter methylation in non-small cell lung and colorectal cancer: clinical implications.
International journal of oncology 2004;24(2):349-55.
2004: Almudena Porras; Susana Zuluaga; Emma Black; Ana Valladares; Alberto M Alvarez; Concetta Ambrosino; Manuel Benito; Angel R Nebreda
P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.
Molecular biology of the cell 2004;15(2):922-33.
2004: Francisco Valdés; Miguel M Murillo; Angela M Valverde; Blanca Herrera; Aránzazu Sánchez; Manuel Benito; Margarita Fernández; Isabel Fabregat
Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes.
Experimental cell research 2004;292(1):209-18.
2003: Almudena Porras; Susana Zuluaga; Ana Valladares; Alberto M Alvarez; Blanca Herrera; Isabel Fabregat; Manuel Benito
Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress.
Endocrinology 2003;144(12):5390-401.
2003: Mónica Arribas; Angela M Valverde; Manuel Benito
Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.
The Journal of biological chemistry 2003;278(46):45189-99.
2003: Angela M Valverde; Deborah J Burks; Isabel Fabregat; Tracey L Fisher; José Carretero; Morris F White; Manuel Benito
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
Diabetes 2003;52(9):2239-48.
2003: Angela M Valverde; Mónica Arribas; Cecilia Mur; Paloma Navarro; Sebastián Pons; Anne-Marie Cassard-Doulcier; C Ronald Kahn; Manuel Benito
Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes.
The Journal of biological chemistry 2003;278(12):10221-31.
2003: Mónica Arribas; Angela M Valverde; Deborah J Burks; Johannes Klein; Robert V Farese; Morris F White; Manuel Benito
Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes.
FEBS letters 2003;536(1-3):161-6.
2003: Cecilia Mur; Mónica Arribas; Manuel Benito; Angela M Valverde
Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation.
Endocrinology 2003;144(2):581-93.
2003: Teresa Teruel; Rosario Hernandez; Manuel Benito; Margarita Lorenzo
Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.
The Journal of biological chemistry 2003;278(1):263-9.
2002: Francisco Valdés; Alberto M Alvarez; Annamaria Locascio; Sonia Vega; Blanca Herrera; Margarita Fernández; Manuel Benito; M Angela Nieto; Isabel Fabregat
The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes.
Molecular cancer research : MCR 2002;1(1):68-78.
2002: Alberto Moran; Pilar Iniesta; Carmen de Juan; Rosa González-Quevedo; Andrés Sánchez-Pernaute; Eduardo Díaz-Rubio; Santiago Ramón y Cajal; Antonio Torres; Jose L Balibrea; Manuel Benito
Stromelysin-1 promoter mutations impair gelatinase B activation in high microsatellite instability sporadic colorectal tumors.
Cancer research 2002;62(13):3855-60.
2002: Blanca Herrera; Margarita Fernández; Manuel Benito; Isabel Fabregat
cIAP-1, but not XIAP, is cleaved by caspases during the apoptosis induced by TGF-beta in fetal rat hepatocytes.
FEBS letters 2002;520(1-3):93-6.
2002: Almudena Porras; Ana Valladares; Alberto M Alvarez; César Roncero; Manuel Benito
Differential role of PPAR gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes.
FEBS letters 2002;520(1-3):58-62.
2002: Ruben Conejo; Cristina de Alvaro; Manuel Benito; Antonio Cuadrado; Margarita Lorenzo
Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway.
Oncogene 2002;21(23):3739-53.
2002: Carmen de Juan; Pilar Iniesta; Rosa González-Quevedo; Alberto Moran; Andrés Sánchez-Pernaute; Antonio-Jose Torres; Jose L Balibrea; Eduardo Díaz-Rubio; Jesús Cruces; Manuel Benito
Genomic organization of a novel glycosylphosphatidylinositol MAM gene expressed in human tissues and tumors.
Oncogene 2002;21(19):3089-94.
2002: Trinidad Caldes; Javier Godino; Miguel de la Hoya; Iciar Garcia Carbonero; Pedro Perez-Segura; Charis Eng; Manuel Benito; Eduardo Diaz-Rubio
Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain.
International journal of cancer. Journal international du cancer 2002;98(5):774-9.
2002: Cecilia Mur; Angela M Valverde; C Ronald Kahn; Manuel Benito
Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes.
Diabetes 2002;51(3):743-54.
2002: Rosa González-Quevedo; Pilar Iniesta; Alberto Moran; Carmen de Juan; Andrés Sánchez-Pernaute; Cristina Fernández; Antonio Torres; Eduardo Díaz-Rubio; Jose L Balibrea; Manuel Benito
Cooperative role of telomerase activity and p16 expression in the prognosis of non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(1):254-62.
2001: Javier Godino; Miguel de la Hoya; Eduardo Diaz-Rubio; Manuel Benito; Trinidad Caldés
Eight novel germline MLH1 and MSH2 mutations in hereditary non-polyposis colorectal cancer families from Spain.
Human mutation 2001;18(6):549.
2001: C Guerra; Paloma Navarro; Angela M Valverde; Mónica Arribas; J Brüning; Leslie P Kozak; C Ronald Kahn; Manuel Benito
Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.
The Journal of clinical investigation 2001;108(8):1205-13.
2001: Blanca Herrera; Margarita Fernández; Alberto M Alvarez; César Roncero; Manuel Benito; J Gil; Isabel Fabregat
Activation of caspases occurs downstream from radical oxygen species production, Bcl-xL down-regulation, and early cytochrome C release in apoptosis induced by transforming growth factor beta in rat fetal hepatocytes.
Hepatology (Baltimore, Md.) 2001;34(3):548-56.
2001: Blanca Herrera; Margarita Fernández; César Roncero; Juan-José Ventura; Almudena Porras; Ana Valladares; Manuel Benito; Isabel Fabregat
Activation of p38MAPK by TGF-beta in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death.
FEBS letters 2001;499(3):225-9.
2001: Angela M Valverde; Cecilia Mur; Sebastián Pons; Alberto M Alvarez; Morris F White; C Ronald Kahn; Manuel Benito
Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.
Molecular and cellular biology 2001;21(7):2269-80.
2001: Ana Valladares; César Roncero; Manuel Benito; Almudena Porras
TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs. Opposite effect of p38MAPK.
FEBS letters 2001;493(1):6-11.
2001: Blanca Herrera; Alberto M Alvarez; Aránzazu Sánchez; Margarita Fernández; César Roncero; Manuel Benito; Isabel Fabregat
Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):741-51.
2001: Ruben Conejo; Angela M Valverde; Manuel Benito; Margarita Lorenzo
Insulin produces myogenesis in C2C12 myoblasts by induction of NF-kappaB and downregulation of AP-1 activities.
Journal of cellular physiology 2001;186(1):82-94.
2000: Ana Valladares; Alberto M Alvarez; Juan-José Ventura; César Roncero; Manuel Benito; Almudena Porras
p38 mitogen-activated protein kinase mediates tumor necrosis factor-alpha-induced apoptosis in rat fetal brown adipocytes.
Endocrinology 2000;141(12):4383-95.
2000: Ana Valladares; Almudena Porras; Alberto M Alvarez; César Roncero; Manuel Benito
Noradrenaline induces brown adipocytes cell growth via beta-receptors by a mechanism dependent on ERKs but independent of cAMP and PKA.
Journal of cellular physiology 2000;185(3):324-30.
2000: Paloma Navarro; Angela M Valverde; J L Rohn; Manuel Benito; Margarita Lorenzo
Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2000;10(5):256-66.
2000: Pilar Iniesta; MJ Massa; Rosa González-Quevedo; Carmen de Juan; Alberto Moran; Andrés Sánchez-Pernaute; Javier Cerdán; Antonio Torres; Jose L Balibrea; Manuel Benito
Loss of heterozygosity at 3p23 is correlated with poor survival in patients with colorectal carcinoma.
Cancer 2000;89(6):1220-7.
2000: Trinidad Caldés; Javier Godino; Pedro Perez-Segura; Miguel de la Hoya; Eduardo Diaz-Rubio; Manuel Benito
New mutation in the hMSH2 gene in a Spanish Muir-Torre syndrome.
The American journal of gastroenterology 2000;95(9):2389-90.
2000: Isabel Fabregat; Blanca Herrera; Margarita Fernández; Alberto M Alvarez; Aránzazu Sánchez; César Roncero; Juan-José Ventura; Angela M Valverde; Manuel Benito
Epidermal growth factor impairs the cytochrome C/caspase-3 apoptotic pathway induced by transforming growth factor beta in rat fetal hepatocytes via a phosphoinositide 3-kinase-dependent pathway.
Hepatology (Baltimore, Md.) 2000;32(3):528-35.
2000: Angela M Valverde; M Lorenzo; Paloma Navarro; Cecilia Mur; Manuel Benito
Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C zeta-dependent manner.
FEBS letters 2000;472(1):153-8.
2000: Rosa González-Quevedo; Carmen de Juan; MJ Massa; Andrés Sánchez-Pernaute; Antonio Torres; Jose L Balibrea; Manuel Benito; Pilar Iniesta
Detection of telomerase activity in human carcinomas using a trap-ELISA method: correlation with hTR and hTERT expression.
International journal of oncology 2000;16(3):623-8.
2000: Aránzazu Sánchez; Alberto M Alvarez; Roser Pagan; César Roncero; Senén Vilaró; Manuel Benito; Isabel Fabregat
Fibronectin regulates morphology, cell organization and gene expression of rat fetal hepatocytes in primary culture.
Journal of hepatology 2000;32(2):242-50.
1999: MJ Massa; Pilar Iniesta; Rosa González-Quevedo; Carmen de Juan; Trinidad Caldés; Andrés Sánchez-Pernaute; Javier Cerdán; Antonio-Jose Torres; Jose L Balibrea; Manuel Benito
Differential prognosis of replication error phenotype and loss of heterozygosity in sporadic colorectal cancer.
European journal of cancer (Oxford, England : 1990) 1999;35(12):1676-82.
1999: Angela M Valverde; C Ronald Kahn; Manuel Benito
Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.
Diabetes 1999;48(11):2122-31.
1999: Aránzazu Sánchez; Alberto M Alvarez; J M López Pedrosa; César Roncero; Manuel Benito; Isabel Fabregat
Apoptotic response to TGF-beta in fetal hepatocytes depends upon their state of differentiation.
Experimental cell research 1999;252(2):281-91.
1999: Carmen de Juan; Pilar Iniesta; J Cruces; A Sanchez; MJ Massa; R Gonzalez-Quevedo; Antonio-Jose Torres; Jose L Balibrea; Manuel Benito
DNA amplification on chromosome 6p12 in non small cell lung cancer detected by arbitrarily primed polymerase chain reaction.
International journal of cancer. Journal international du cancer 1999;84(4):344-9.
1999: Paloma Navarro; Angela M Valverde; Manuel Benito; Margarita Lorenzo
Activated Ha-ras induces apoptosis by association with phosphorylated Bcl-2 in a mitogen-activated protein kinase-independent manner.
The Journal of biological chemistry 1999;274(27):18857-63.
1999: Juan-José Ventura; César Roncero; Isabel Fabregat; Manuel Benito
Glucocorticoid receptor down-regulates c-Jun amino terminal kinases induced by tumor necrosis factor alpha in fetal rat hepatocyte primary cultures.
Hepatology (Baltimore, Md.) 1999;29(3):849-57.
1999: Paloma Navarro; Angela M Valverde; Ruben Conejo; Manuel Benito; Margarita Lorenzo
Inhibition of caspases rescues brown adipocytes from apoptosis downregulating BCL-XS and upregulating BCL-2 gene expression.
Experimental cell research 1999;246(2):301-7.
1999: Angela M Valverde; Paloma Navarro; Teresa Teruel; Ruben Conejo; Manuel Benito; Margarita Lorenzo
Insulin and insulin-like growth factor I up-regulate GLUT4 gene expression in fetal brown adipocytes, in a phosphoinositide 3-kinase-dependent manner.
The Biochemical journal 1999;337 ( Pt 3)():397-405.
1998: A M Valverde; Paloma Navarro; Manuel Benito; Margarita Lorenzo
H-ras induces glucose uptake in brown adipocytes in an insulin- and phosphatidylinositol 3-kinase-independent manner.
Experimental cell research 1998;243(2):274-81.
1998: Paloma Navarro; Angela M Valverde; Manuel Benito; Margarita Lorenzo
Insulin/IGF-I rescues immortalized brown adipocytes from apoptosis down-regulating Bcl-xS expression, in a PI 3-kinase- and map kinase-dependent manner.
Experimental cell research 1998;243(2):213-21.
1998: Andrés Sánchez-Pernaute; Antonio Torres; Pilar Iniesta; Florentino Hernando; Ana Gómez; O González; Carmen de Juan; Elia Pérez-Aguirre; María Luisa Maestro; J A López-Asenjo; Manuel Benito; Jose L Balibrea
Prognostic significance of p53 gene mutations in squamous cell carcinoma of the lung.
Oncology reports 1998;5(5):1129-33.
1998: Pilar Iniesta; FJ Vega; Trinidad Caldés; MJ Massa; Carmen de Juan; Francisca Cerdán; Aránzazu Sánchez; JA López; Antonio-Jose Torres; Jose L Balibrea; Manuel Benito
p53 exon 7 mutations as a predictor of poor prognosis in patients with colorectal cancer.
Cancer letters 1998;130(1-2):153-60.
1998: Aránzazu Sánchez; Roser Pagan; Alberto M Alvarez; César Roncero; Senén Vilaró; Manuel Benito; Isabel Fabregat
Transforming growth factor-beta (TGF-beta) and EGF promote cord-like structures that indicate terminal differentiation of fetal hepatocytes in primary culture.
Experimental cell research 1998;242(1):27-37.
1998: Teresa Teruel; Angela M Valverde; Paloma Navarro; Manuel Benito; Margarita Lorenzo
Inhibition of PI 3-kinase and RAS blocks IGF-I and insulin-induced uncoupling protein 1 gene expression in brown adipocytes.
Journal of cellular physiology 1998;176(1):99-109.
1998: Carmen de Juan; Pilar Iniesta; FJ Vega; M A Peinado; C Fernandez; Trinidad Caldés; MJ Massa; JA López; Aránzazu Sánchez; Antonio-Jose Torres; Jose L Balibrea; Manuel Benito
Prognostic value of genomic damage in non-small-cell lung cancer.
British journal of cancer 1998;77(11):1971-7.
1998: Almudena Porras; Alberto M Alvarez; Ana Valladares; Manuel Benito
p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-I/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytes.
Molecular endocrinology (Baltimore, Md.) 1998;12(6):825-34.
1998: Angela M Valverde; Margarita Lorenzo; Sebastián Pons; Morris F White; Manuel Benito
Insulin receptor substrate (IRS) proteins IRS-1 and IRS-2 differential signaling in the insulin/insulin-like growth factor-I pathways in fetal brown adipocytes.
Molecular endocrinology (Baltimore, Md.) 1998;12(5):688-97.
1998: Trinidad Caldes; Pilar Iniesta; FJ Vega; Carmen de Juan; J A Lopez; Eduardo Diaz-Rubio; C Fernandez; J Cerdan; Jose L Balibrea; Manuel Benito
Comparative survival analysis of p53 gene mutations and protein accumulation in colorectal cancer.
Oncology 1998;55(3):249-57.
1998: César Roncero; Juan-José Ventura; Aránzazu Sánchez; Brigitte Bois-Joyeux; M L Mesa; H Thomassin; Jean-Louis Danan; Manuel Benito; Isabel Fabregat
Phorbol esters down-regulate alpha-fetoprotein gene expression without affecting growth in fetal hepatocytes in primary culture.
Biochimica et biophysica acta 1998;1402(2):151-64.
1998: Angela M Valverde; Teresa Teruel; Paloma Navarro; Manuel Benito; Margarita Lorenzo
Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes.
Endocrinology 1998;139(3):1229-38.
1998: Pilar Iniesta; Carmen de Juan; Trinidad Caldés; FJ Vega; MJ Massa; Francisca Cerdán; JA López; Cristina Fernández; Aránzazu Sánchez; Antonio-Jose Torres; Jose L Balibrea; Manuel Benito
Genetic abnormalities and microsatellite instability in colorectal cancer.
Cancer detection and prevention 1998;22(5):383-95.
1997: Almudena Porras; Alberto M Alvarez; Ana Valladares; Manuel Benito
TNF-alpha induces apoptosis in rat fetal brown adipocytes in primary culture.
FEBS letters 1997;416(3):324-8.
1997: Aránzazu Sánchez; Alberto M Alvarez; Manuel Benito; Isabel Fabregat
Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor beta in fetal rat hepatocytes in primary culture.
Hepatology (Baltimore, Md.) 1997;26(4):935-43.
1997: Angela M Valverde; Margarita Lorenzo; Teresa Teruel; Manuel Benito
Alterations in the insulin signaling pathway induced by immortalization and H-ras transformation of brown adipocytes.
Endocrinology 1997;138(8):3195-206.
1997: Angela M Valverde; Margarita Lorenzo; Paloma Navarro; Manuel Benito
Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes.
Molecular endocrinology (Baltimore, Md.) 1997;11(5):595-607.
1997: FJ Vega; Pilar Iniesta; Trinidad Caldés; A Sanchez; JA López; Carmen de Juan; Eduardo Diaz-Rubio; Antonio Torres; Jose L Balibrea; Manuel Benito
p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer.
British journal of cancer 1997;76(1):44-51.
1996: Almudena Porras; ER Hernández; Manuel Benito
Ras proteins mediate induction of uncoupling protein, IGF-I, and IGF-I receptor in rat fetal brown adipocyte cell lines.
DNA and cell biology 1996;15(11):921-8.
1996: Teresa Teruel; Angela M Valverde; Manuel Benito; Margarita Lorenzo
Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures.
The Biochemical journal 1996;319 ( Pt 2)():627-32.
1996: C Molero; Angela M Valverde; Teresa Teruel; Manuel Benito; Margarita Lorenzo
Initial expression of phosphoenolpyruvate carboxykinase gene in fetal hepatocytes: role of transcription factors.
Journal of hepatology 1996;25(4):510-7.
1996: Margarita Lorenzo; Angela M Valverde; Teresa Teruel; A Alvarez; Manuel Benito
p21ras induced differentiation-related gene expression in fetal brown adipocyte primary cells and cell lines.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(9):1251-9.
1996: Angela M Valverde; Teresa Teruel; Margarita Lorenzo; Manuel Benito
Involvement of Raf-1 kinase and protein kinase C zeta in insulin-like growth factor I-induced brown adipocyte mitogenic signaling cascades: inhibition by cyclic adenosine 3',5'-monophosphate.
Endocrinology 1996;137(9):3832-41.
1996: Manuel Benito; Angela M Valverde; Margarita Lorenzo
IGF-I: a mitogen also involved in differentiation processes in mammalian cells.
The international journal of biochemistry & cell biology 1996;28(5):499-510.
1996: Isabel Fabregat; Aránzazu Sánchez; Alberto M Alvarez; T Nakamura; Manuel Benito
Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor-beta in fetal hepatocytes in primary culture.
FEBS letters 1996;384(1):14-8.
1996: Aránzazu Sánchez; Alberto M Alvarez; Manuel Benito; Isabel Fabregat
Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: involvement of reactive oxygen intermediates.
The Journal of biological chemistry 1996;271(13):7416-22.
1996: M L Mesa; R Carrizosa; C Martínez-Honduvilla; Manuel Benito; Isabel Fabregat
Changes in rat liver gene expression induced by thioacetamide: protective role of S-adenosyl-L-methionine by a glutathione-dependent mechanism.
Hepatology (Baltimore, Md.) 1996;23(3):600-6.
1996: Teresa Teruel; Angela M Valverde; Manuel Benito; Margarita Lorenzo
Transforming growth factor beta 1 induces mitogenesis in fetal rat brown adipocytes.
Journal of cellular physiology 1996;166(3):577-84.
1996: C Guerra; César Roncero; Almudena Porras; M Fernández; Manuel Benito
Triiodothyronine induces the transcription of the uncoupling protein gene and stabilizes its mRNA in fetal rat brown adipocyte primary cultures.
The Journal of biological chemistry 1996;271(4):2076-81.
1995: César Roncero; Isabel Fabregat; Manuel Benito
Regulation of gene expression by interleukin-6 in fetal rat hepatocyte primary cultures: role of epidermal growth factor and dexamethasone.
Hepatology (Baltimore, Md.) 1995;22(6):1769-75.
1995: A Sanchez; Alberto M Alvarez; Manuel Benito; Isabel Fabregat
Transforming growth factor beta modulates growth and differentiation of fetal hepatocytes in primary culture.
Journal of cellular physiology 1995;165(2):398-405.
1995: Teresa Teruel; Angela M Valverde; A Alvarez; Manuel Benito; Margarita Lorenzo
Differentiation of rat brown adipocytes during late foetal development: role of insulin-like growth factor I.
The Biochemical journal 1995;310 ( Pt 3)():771-6.
1995: Margarita Lorenzo; C Molero; Angela M Valverde; Teresa Teruel; Manuel Benito
Hormonal regulation of differentiation-related gene expression in fetal hepatocyte primary cultures.
Biochemical Society transactions 1995;23(3):437S.
1995: Teresa Teruel; Angela M Valverde; Manuel Benito; Margarita Lorenzo
Transforming growth factor beta 1 induces differentiation-specific gene expression in fetal rat brown adipocytes.
FEBS letters 1995;364(2):193-7.
1995: Angela M Valverde; Margarita Lorenzo; Teresa Teruel; Manuel Benito
cAMP inhibits IGF-I-induced mitogenesis in fetal rat brown adipocytes: role of p21 ras.
Experimental cell research 1995;218(1):305-9.
1994: Carmen de Juan; Aránzazu Sánchez; T Nakamura; Isabel Fabregat; Manuel Benito
Hepatocyte growth factor up-regulates met expression in rat fetal hepatocytes in primary culture.
Biochemical and biophysical research communications 1994;204(3):1364-70.
1994: C Guerra; Manuel Benito; M Fernández
IGF-I induces the uncoupling protein gene expression in fetal rat brown adipocyte primary cultures: role of C/EBP transcription factors.
Biochemical and biophysical research communications 1994;201(2):813-9.
1994: Isabel Fabregat; Carmen de Juan; César Roncero; Manuel Benito
Noradrenergic modulation of albumin expression in growth-stimulated adult rat hepatocytes in primary culture.
Journal of cellular physiology 1994;158(3):513-7.
1994: C Guerra; Almudena Porras; César Roncero; Manuel Benito; M Fernandez
Triiodothyronine induces the expression of the uncoupling protein in long term fetal rat brown adipocyte primary cultures: role of nuclear thyroid hormone receptor expression.
Endocrinology 1994;134(3):1067-74.
1994: C Molero; Manuel Benito; Margarita Lorenzo
Glucose-6-phosphate dehydrogenase gene expression in fetal hepatocyte primary cultures under nonproliferative and proliferative conditions.
Experimental cell research 1994;210(1):26-32.
1993: Margarita Lorenzo; Angela M Valverde; Teresa Teruel; Manuel Benito
IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes.
The Journal of cell biology 1993;123(6 Pt 1):1567-75.
1993: C Molero; Manuel Benito; Margarita Lorenzo
Regulation of malic enzyme gene expression by nutrients, hormones, and growth factors in fetal hepatocyte primary cultures.
Journal of cellular physiology 1993;155(1):197-203.
1992: Isabel Fabregat; Carmen de Juan; T Nakamura; Manuel Benito
Growth stimulation of rat fetal hepatocytes in response to hepatocyte growth factor: modulation of c-myc and c-fos expression.
Biochemical and biophysical research communications 1992;189(2):684-90.
1992: Carmen de Juan; Manuel Benito; A Alvarez; Isabel Fabregat
Differential proliferative response of cultured fetal and regenerating hepatocytes to growth factors and hormones.
Experimental cell research 1992;202(2):495-500.
1992: Carmen de Juan; Manuel Benito; Isabel Fabregat
Regulation of albumin expression in fetal rat hepatocytes cultured under proliferative conditions: role of epidermal growth factor and hormones.
Journal of cellular physiology 1992;152(1):95-101.
1992: C Molero; Angela M Valverde; Manuel Benito; Margarita Lorenzo
Phosphoenolpyruvate carboxykinase and glucose-6-phosphate dehydrogenase expression in fetal hepatocyte primary cultures under proliferative conditions.
Experimental cell research 1992;200(2):295-300.
1991: Angela M Valverde; Manuel Benito; Margarita Lorenzo
Proliferation of fetal brown adipocyte primary cultures: relationship with the genetic expression of glucose 6 phosphate dehydrogenase.
Experimental cell research 1991;194(2):232-7.
1990: Almudena Porras; M Peñas; M Fernández; Manuel Benito
Development of the uncoupling protein in the rat brown-adipose tissue during the perinatal period. Its relationship with the mitochondrial GDP-binding and GDP-sensitive ion permeabilities and respiration.
European journal of biochemistry / FEBS 1990;187(3):671-5.
1989: Margarita Lorenzo; Isabel Fabregat; Manuel Benito
Hormonal regulation of malic enzyme expression in primary cultures of foetal brown adipocytes.
Biochemical and biophysical research communications 1989;163(1):341-7.
1989: Almudena Porras; M Fernández; Manuel Benito
Adrenergic regulation of the uncoupling protein expression in foetal rat brown adipocytes in primary culture.
Biochemical and biophysical research communications 1989;163(1):541-7.
1989: César Roncero; Margarita Lorenzo; Isabel Fabregat; Manuel Benito
Rates of lipogenesis in fetal hepatocytes in suspension and in primary culture: hormonal effects.
Biochimica et biophysica acta 1989;1012(3):320-4.
1989: Isabel Fabregat; Margarita Lorenzo; Manuel Benito
Precocious induction of malic enzyme by nutritional and hormonal factors in rat foetal hepatocyte primary cultures.
Biochemical and biophysical research communications 1989;161(3):1028-34.
1988: Margarita Lorenzo; César Roncero; Isabel Fabregat; Manuel Benito
Hormonal regulation of rat foetal lipogenesis in brown-adipocyte primary cultures.
The Biochemical journal 1988;251(2):617-20.
1987: César Roncero; Margarita Lorenzo; Manuel Benito
Regulation of rat foetal lipogenesis in brown adipose tissue in vivo and in isolated brown adipocytes during the last day of, and after prolonged, gestation.
The Biochemical journal 1987;243(2):617-20.
1986: Margarita Lorenzo; César Roncero; Manuel Benito
The role of prolactin and progesterone in the regulation of lipogenesis in maternal and foetal rat liver in vivo and in isolated hepatocytes during the last day of gestation.
The Biochemical journal 1986;239(1):135-9.