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Ken Ohashi

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Yoko Iizuka; Ken Ohashi; Kazuhisa Tsukamoto; Kohjiro Ueki; Takashi Kadowaki
Education and management of diabetes at The University of Tokyo Hospital.
Keisuke Ohta; Motohiro Sekiya; Hiroshi Uozaki; Masaki Igarashi; Satoru Takase; Masayoshi Kumagai; Masakatsu Takanashi; Yoshinori Takeuchi; Yoshihiko Izumida; Midori Kubota; Makiko Nishi; Hiroaki Okazaki; Yoko Iizuka; Naoya Yahagi; Hiroaki Yagyu; Masashi Fukayama; Takashi Kadowaki; Ken Ohashi; Shun Ishibashi; Jun-ichi Osuga
Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.
Tadayuki Tsujita; Li Li; Hitomi Nakajima; Noriko Iwamoto; Yaeko Nakajima-Takagi; Ken Ohashi; Koichi Kawakami; Yoshito Kumagai; Bruce A Freeman; Masayuki Yamamoto; Makoto Kobayashi
Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish.

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All Publications

2011: Yoko Iizuka; Ken Ohashi; Kazuhisa Tsukamoto; Kohjiro Ueki; Takashi Kadowaki
Education and management of diabetes at The University of Tokyo Hospital.
Journal of diabetes 2011;3(2):104-8.
2011: Keisuke Ohta; Motohiro Sekiya; Hiroshi Uozaki; Masaki Igarashi; Satoru Takase; Masayoshi Kumagai; Masakatsu Takanashi; Yoshinori Takeuchi; Yoshihiko Izumida; Midori Kubota; Makiko Nishi; Hiroaki Okazaki; Yoko Iizuka; Naoya Yahagi; Hiroaki Yagyu; Masashi Fukayama; Takashi Kadowaki; Ken Ohashi; Shun Ishibashi; Jun-ichi Osuga
Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.
Biochemical and biophysical research communications 2011;404(1):254-60.
2011: Tadayuki Tsujita; Li Li; Hitomi Nakajima; Noriko Iwamoto; Yaeko Nakajima-Takagi; Ken Ohashi; Koichi Kawakami; Yoshito Kumagai; Bruce A Freeman; Masayuki Yamamoto; Makoto Kobayashi
Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish.
Genes to cells : devoted to molecular & cellular mechanisms 2011;16(1):46-57.
2009: Motohiro Sekiya; Naoya Yahagi; Yoshiaki Tamura; Hiroaki Okazaki; Masaki Igarashi; Keisuke Ohta; Mikio Takanashi; Masayoshi Kumagai; Satoru Takase; Makiko Nishi; Yoshinori Takeuchi; Yoshihiko Izumida; Midori Kubota; Ken Ohashi; Yoko Iizuka; Hiroaki Yagyu; Takanari Gotoda; Ryozo Nagai; Hitoshi Shimano; Nobuhiro Yamada; Takashi Kadowaki; Shun Ishibashi; Jun-ichi Osuga
Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.
Biochemical and biophysical research communications 2009;387(3):511-5.
2009: Motohiro Sekiya; Jun-ichi Osuga; Shuichi Nagashima; Taichi Ohshiro; Masaki Igarashi; Hiroaki Okazaki; Manabu Takahashi; Fumiko Tazoe; Taeko Wada; Keisuke Ohta; Mikio Takanashi; Masayoshi Kumagai; Makiko Nishi; Satoru Takase; Naoya Yahagi; Hiroaki Yagyu; Ken Ohashi; Ryozo Nagai; Takashi Kadowaki; Yusuke Furukawa; Shun Ishibashi
Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
Cell metabolism 2009;10(3):219-28.
2009: Wataru Fukuo; Kazuhiro Yoshiuchi; Ken Ohashi; Hitomi Togashi; Rie Sekine; H Kikuchi; Noriyuki Sakamoto; Shuji Inada; Fumiyo Sato; Takashi Kadowaki; Akira Akabayashi
Development of a hand-held personal digital assistant-based food diary with food photographs for Japanese subjects.
Journal of the American Dietetic Association 2009;109(7):1232-6.
2009: Masumi Hara; Yoshihiko Izumida; Nobuhiro Sato; Ken Ohashi; Jun-ichi Osuga; Kazuyuki Tobe; Kazuhisa Tsukamoto; Takashi Kadowaki
Successful desensitization by glargine administration in a patient with insulin allergy: a case report.
Diabetes research and clinical practice 2009;84(3):e48-9.
2008: Hiroaki Okazaki; Masaki Igarashi; Makiko Nishi; Motohiro Sekiya; Makiko Tajima; Satoru Takase; Mikio Takanashi; Keisuke Ohta; Yoshiaki Tamura; Sachiko Okazaki; Naoya Yahagi; Ken Ohashi; Michiyo Amemiya-Kudo; Yoshimi Nakagawa; Ryozo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.
The Journal of biological chemistry 2008;283(48):33357-64.
2008: Motohiro Sekiya; Jun-ichi Osuga; Naoya Yahagi; Hiroaki Okazaki; Yoshiaki Tamura; Masaki Igarashi; Satoru Takase; Kenji Harada; Sachiko Okazaki; Yoko Iizuka; Ken Ohashi; Hiroaki Yagyu; Mitsuyo Okazaki; Takanari Gotoda; Ryozo Nagai; Takashi Kadowaki; Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi
Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis.
Journal of lipid research 2008;49(8):1829-38.
2007: Yoshinori Takeuchi; Naoya Yahagi; Yoshimi Nakagawa; Takashi Matsuzaka; Ritsuko Shimizu; Motohiro Sekiya; Yoko Iizuka; Ken Ohashi; Takanari Gotoda; Masayuki Yamamoto; Ryozo Nagai; Takashi Kadowaki; Nobuhiro Yamada; Jun-ichi Osuga; Hitoshi Shimano
In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression.
Biochemical and biophysical research communications 2007;363(2):329-35.
2007: Takashi Matsuzaka; Hitoshi Shimano; Naoya Yahagi; Toyonori Kato; Ayaka Atsumi; Takashi Yamamoto; Noriyuki Inoue; Mayumi Ishikawa; Sumiyo Okada; Naomi Ishigaki; Hitoshi Iwasaki; Yuko Iwasaki; Tadayoshi Karasawa; Shin Kumadaki; Toshiyuki Matsui; Motohiro Sekiya; Ken Ohashi; Alyssa H Hasty; Yoshimi Nakagawa; Akimitsu Takahashi; Hiroaki Suzuki; Shigeru Yatoh; Hirohito Sone; Hideo Toyoshima; Jun-ichi Osuga; Nobuhiro Yamada
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Nature medicine 2007;13(10):1193-202.
2007: Ken Ohashi
[Abetalipoproteinemia].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 7():588-91.
2007: Keisuke Ohta; Ken Ohashi
[Complications of low plasma HDL-cholesterol levels].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 7():678-81.
2007: Motohiro Sekiya; Naoya Yahagi; Takashi Matsuzaka; Yoshinori Takeuchi; Yoshimi Nakagawa; Haruka Takahashi; Hiroaki Okazaki; Yoko Iizuka; Ken Ohashi; Takanari Gotoda; Shun Ishibashi; Ryozo Nagai; Tsutomu Yamazaki; Takashi Kadowaki; Nobuhiro Yamada; Jun-ichi Osuga; Hitoshi Shimano
SREBP-1-independent regulation of lipogenic gene expression in adipocytes.
Journal of lipid research 2007;48(7):1581-91.
2006: Takekazu Kunieda; Tomoko Fujiyuki; Robert Kucharski; S Foret; S A Ament; A L Toth; Ken Ohashi; Hideaki Takeuchi; Azusa Kamikouchi; Eriko Kage; Mizue Morioka; M Beye; Takeo Kubo; G E Robinson; Ryszard Maleszka
Carbohydrate metabolism genes and pathways in insects: insights from the honey bee genome.
Insect molecular biology 2006;15(5):563-76.
2006: Hiroaki Okazaki; Fumiko Tazoe; Sachiko Okazaki; Noriko Isoo; Kazuhisa Tsukamoto; Motohiro Sekiya; Naoya Yahagi; Yoko Iizuka; Ken Ohashi; Tetsuya Kitamine; Ryuichi Tozawa; Toshihiro Inaba; Hiroaki Yagyu; Mitsuyo Okazaki; Hitoshi Shimano; Norihito Shibata; Hiroyuki Arai; Ryo-Zo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.
Journal of lipid research 2006;47(9):1950-8.
2005: Yuho Najima; Naoya Yahagi; Yoshinori Takeuchi; Takashi Matsuzaka; Motohiro Sekiya; Yoshimi Nakagawa; Michiyo Amemiya-Kudo; Hiroaki Okazaki; Sachiko Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Takashi Kadowaki; Shun Ishibashi; Nobuhiro Yamada; Jun-ichi Osuga; Hitoshi Shimano
High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.
The Journal of biological chemistry 2005;280(30):27523-32.
2005: Naoya Yahagi; Hitoshi Shimano; Kiyoshi Hasegawa; Ken Ohashi; Takashi Matsuzaka; Yuho Najima; Motohiro Sekiya; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Kenichi Ohashi; Ryozo Nagai; Shun Ishibashi; Takashi Kadowaki; Makuuchi Masatoshi; Shin Ohnishi; Jun-ichi Osuga; Nobuhiro Yamada
Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma.
European journal of cancer (Oxford, England : 1990) 2005;41(9):1316-22.
2004: Yoshiaki Tamura; Jun-ichi Osuga; Hideki Adachi; Ryuichi Tozawa; Yasukazu Takanezawa; Ken Ohashi; Naoya Yahagi; Motohiro Sekiya; Hiroaki Okazaki; Sachiko Tomita; Yoko Iizuka; Hiroyuki Koizumi; Toshihiro Inaba; Hiroaki Yagyu; Nobuo Kamada; Hiroshi Suzuki; Hitoshi Shimano; Takashi Kadowaki; Masafumi Tsujimoto; Hiroyuki Arai; Nobuhiro Yamada; Shun Ishibashi
Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide.
The Journal of biological chemistry 2004;279(30):30938-44.
2004: Naoya Yahagi; Hitoshi Shimano; Takashi Matsuzaka; Motohiro Sekiya; Yuho Najima; Sachiko Okazaki; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Noriyuki Inoue; Yoshimi Nakagawa; Yoshinori Takeuchi; Ken Ohashi; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Takashi Kadowaki; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada
p53 involvement in the pathogenesis of fatty liver disease.
The Journal of biological chemistry 2004;279(20):20571-5.
2004: Motohiro Sekiya; Jun-ichi Osuga; Hiroaki Okazaki; Naoya Yahagi; Kenji Harada; Wen-Jun Shen; Yoshiaki Tamura; Sachiko Tomita; Yoko Iizuka; Ken Ohashi; Mitsuyo Okazaki; Masataka Sata; Ryozo Nagai; Toshiro Fujita; Hitoshi Shimano; Fredric B Kraemer; Nobuhiro Yamada; Shun Ishibashi
Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice.
The Journal of biological chemistry 2004;279(15):15084-90.
2004: Takashi Matsuzaka; Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Sachiko Tomita; Motohiro Sekiya; Alyssa H Hasty; Yoshimi Nakagawa; Hirohito Sone; Hideo Toyoshima; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada
Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice.
Diabetes 2004;53(3):560-9.
2003: Ken Ohashi; Jun-ichi Osuga; Ryuichi Tozawa; Tetsuya Kitamine; Hiroaki Yagyu; Motohiro Sekiya; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Naoya Yahagi; Yoko Iizuka; Kenji Harada; Takanari Gotoda; Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi
Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene.
The Journal of biological chemistry 2003;278(44):42936-41.
2003: Naoya Yahagi; Hitoshi Shimano; Takashi Matsuzaka; Yuho Najima; Motohiro Sekiya; Yoshimi Nakagawa; Tomohiro Ide; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Takanari Gotoda; Ryozo Nagai; Satoshi Kimura; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada
p53 Activation in adipocytes of obese mice.
The Journal of biological chemistry 2003;278(28):25395-400.
2003: Tomohiro Ide; Hitoshi Shimano; Tomohiro Yoshikawa; Naoya Yahagi; Michiyo Amemiya-Kudo; Takashi Matsuzaka; Masanori Nakakuki; Shigeru Yatoh; Yoko Iizuka; Sachiko Tomita; Ken Ohashi; Akimitsu Takahashi; Hirohito Sone; Takanari Gotoda; Jun-ichi Osuga; Shun Ishibashi; Nobuhiro Yamada
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1255-67.
2003: Yoshiaki Tamura; Hideki Adachi; Jun-ichi Osuga; Ken Ohashi; Naoya Yahagi; Motohiro Sekiya; Hiroaki Okazaki; Sachiko Tomita; Yoko Iizuka; Hitoshi Shimano; Ryozo Nagai; Satoshi Kimura; Masafumi Tsujimoto; Shun Ishibashi
FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.
The Journal of biological chemistry 2003;278(15):12613-7.
2002: Hiroaki Okazaki; Jun-ichi Osuga; Yoshiaki Tamura; Naoya Yahagi; Sachiko Tomita; Futoshi Shionoiri; Yoko Iizuka; Ken Ohashi; Kenji Harada; Satoshi Kimura; Takanari Gotoda; Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi
Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.
Diabetes 2002;51(12):3368-75.
2002: Hiroaki Okazaki; Jun-ichi Osuga; Kazuhisa Tsukamoto; Noriko Isoo; Tetsuya Kitamine; Yoshiaki Tamura; Sachiko Tomita; Motohiro Sekiya; Naoya Yahagi; Yoko Iizuka; Ken Ohashi; Kenji Harada; Takanari Gotoda; Hitoshi Shimano; Satoshi Kimura; Ryozo Nagai; Nobuhiro Yamada; Shun Ishibashi
Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.
The Journal of biological chemistry 2002;277(35):31893-9.
2002: Yoshiaki Tamura; Shun Ishibashi; Takanari Gotoda; Junko Yasufuku-Takano; Koji Takano; Keisuke Ueki; Shigeo Yamashita; Yoko Iizuka; Naoya Yahagi; Futoshi Shionoiri; Hiroaki Okazaki; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Hitoshi Shimano; Toshiro Fujita; Nobuhiro Yamada; Satoshi Kimura
A kindred of familial acromegaly without evidence for linkage to MEN-1 locus.
Endocrine journal 2002;49(4):425-31.
2002: Michiyo Amemiya-Kudo; Hitoshi Shimano; Alyssa H Hasty; Naoya Yahagi; Tomohiro Yoshikawa; Takashi Matsuzaka; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Ryuichiro Sato; Satoshi Kimura; Shun Ishibashi; Nobuhiro Yamada
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.
Journal of lipid research 2002;43(8):1220-35.
2002: Takashi Matsuzaka; Hitoshi Shimano; Naoya Yahagi; Tomohiro Yoshikawa; Michiyo Amemiya-Kudo; Alyssa H Hasty; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Akimitsu Takahashi; Shigeru Yato; Hirohito Sone; Shun Ishibashi; Nobuhiro Yamada
Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.
Journal of lipid research 2002;43(6):911-20.
2002: Naoya Yahagi; Hitoshi Shimano; Alyssa H Hasty; Takashi Matsuzaka; Tomohiro Ide; Tomohiro Yoshikawa; Michiyo Amemiya-Kudo; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.
The Journal of biological chemistry 2002;277(22):19353-7.
2002: Ken Ohashi
[MTP inhibitors and ACAT inhibitors. An update].
Nihon rinsho. Japanese journal of clinical medicine 2002;60(5):975-83.
2002: Tomohiro Yoshikawa; Hitoshi Shimano; Naoya Yahagi; Tomohiro Ide; Michiyo Amemiya-Kudo; Takashi Matsuzaka; Masanori Nakakuki; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Akimitsu Takahashi; Hirohito Sone; Jun-ichi Osuga Ji; Takanari Gotoda; Shun Ishibashi; Nobuhiro Yamada
Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements.
The Journal of biological chemistry 2002;277(3):1705-11.
2001: Alyssa H Hasty; Hitoshi Shimano; Jun-ichi Osuga; I Namatame; Akimitsu Takahashi; Naoya Yahagi; S Perrey; Yoko Iizuka; Yoshiaki Tamura; Michiyo Amemiya-Kudo; Tomohiro Yoshikawa; Hiroaki Okazaki; Ken Ohashi; Kenji Harada; Takashi Matsuzaka; Hirohito Sone; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor.
The Journal of biological chemistry 2001;276(40):37402-8.
2001: Hideaki Takeuchi; Eriko Kage; Miyuki Sawata; Azusa Kamikouchi; Ken Ohashi; M Ohara; Tomoko Fujiyuki; Takekazu Kunieda; K Sekimizu; Shunji Natori; Takeo Kubo
Identification of a novel gene, Mblk-1, that encodes a putative transcription factor expressed preferentially in the large-type Kenyon cells of the honeybee brain.
Insect molecular biology 2001;10(5):487-94.
2001: Tomohiro Yoshikawa; Hitoshi Shimano; Michiyo Amemiya-Kudo; Naoya Yahagi; Alyssa H Hasty; Takashi Matsuzaka; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Satoshi Kimura; Shun Ishibashi; Nobuhiro Yamada
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter.
Molecular and cellular biology 2001;21(9):2991-3000.
2001: Ryuichi Tozawa; Shun Ishibashi; Jun-ichi Osuga; Kazuhiko Yamamoto; Hiroaki Yagyu; Ken Ohashi; Yoshiaki Tamura; Naoya Yahagi; Yoko Iizuka; Hiroaki Okazaki; Kenji Harada; Takanari Gotoda; Hitoshi Shimano; Satoshi Kimura; Ryozo Nagai; Nobuhiro Yamada
Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its obligate requirement for the stable expression of oligomeric receptor.
The Journal of biological chemistry 2001;276(16):12624-8.
2001: Ken Ohashi
[Anderson's disease/chylomicron retention disease].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 3():261-5.
2001: Ken Ohashi
[Normotriglyceridemic abetalipoproteinemia].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 3():258-60.
2001: Ken Ohashi
[Abetalipoproteinemia].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 3():250-3.
2001: Z Chen; Shun Ishibashi; S Perrey; Takanari Gotoda; Tetsuya Kitamine; Yoshiaki Tamura; Hiroaki Okazaki; Naoya Yahagi; Yoko Iizuka; Futoshi Shionoiri; Ken Ohashi; Kenji Harada; Hitoshi Shimano; Ryozo Nagai; Nobuhiro Yamada
Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(3):372-7.
2001: S Perrey; Shun Ishibashi; Naoya Yahagi; Jun-ichi Osuga; Ryuichi Tozawa; Hiroaki Yagyu; Ken Ohashi; Takanari Gotoda; Kenji Harada; Z Chen; Yoko Iizuka; Futoshi Shionoiri; Nobuhiro Yamada
Thiazolidinedione- and tumor necrosis factor alpha-induced downregulation of peroxisome proliferator-activated receptor gamma mRNA in differentiated 3T3-L1 adipocytes.
Metabolism: clinical and experimental 2001;50(1):36-40.
2001: S Perrey; Shun Ishibashi; Tetsuya Kitamine; Jun-ichi Osuga; Hiroaki Yagyu; Z Chen; Futoshi Shionoiri; Yoko Iizuka; Naoya Yahagi; Yoshiaki Tamura; Ken Ohashi; Kenji Harada; Takanari Gotoda; Nobuhiro Yamada
The LDL receptor is the major pathway for beta-VLDL uptake by mouse peritoneal macrophages.
Atherosclerosis 2001;154(1):51-60.
2000: Michiyo Amemiya-Kudo; Hitoshi Shimano; Tomohiro Yoshikawa; Naoya Yahagi; Alyssa H Hasty; Hiroaki Okazaki; Yoshiaki Tamura; Futoshi Shionoiri; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Ryuichiro Sato; Satoshi Kimura; Shun Ishibashi; Nobuhiro Yamada
Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene.
The Journal of biological chemistry 2000;275(40):31078-85.
2000: Alyssa H Hasty; Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; S Perrey; Tomohiro Yoshikawa; Jun-ichi Osuga; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Futoshi Shionoiri; Ken Ohashi; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.
The Journal of biological chemistry 2000;275(40):31069-77.
2000: Ken Ohashi; Shun Ishibashi; Jun-ichi Osuga; Ryuichi Tozawa; Kenji Harada; Naoya Yahagi; Futoshi Shionoiri; Yoko Iizuka; Yoshiaki Tamura; Ryozo Nagai; D R Illingworth; Takanari Gotoda; Nobuhiro Yamada
Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia.
Journal of lipid research 2000;41(8):1199-204.
2000: Hiroaki Yagyu; Tetsuya Kitamine; Jun-ichi Osuga; Ryuichi Tozawa; Z Chen; Y Kaji; Toru Oka; S Perrey; Yoshiaki Tamura; Ken Ohashi; Hiroaki Okazaki; Naoya Yahagi; Futoshi Shionoiri; Yoko Iizuka; Kenji Harada; Hitoshi Shimano; H Yamashita; Takanari Gotoda; Nobuhiro Yamada; Shun Ishibashi
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia.
The Journal of biological chemistry 2000;275(28):21324-30.
2000: Takeo Kubo; Ken Ohashi; Miyuki Sawata; Azusa Kamikouchi; Hideaki Takeuchi
[Molecular biology concerning to the honeybee sociality: how can we approach the evolution of insect sociality?].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(7):1229-36.
1999: Naoya Yahagi; Hitoshi Shimano; Alyssa H Hasty; Michiyo Amemiya-Kudo; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Futoshi Shionoiri; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.
The Journal of biological chemistry 1999;274(50):35840-4.
1999: Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; Alyssa H Hasty; Jun-ichi Osuga; Yoshiaki Tamura; Futoshi Shionoiri; Yoko Iizuka; Ken Ohashi; Kenji Harada; Takanari Gotoda; Shun Ishibashi; Nobuhiro Yamada
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.
The Journal of biological chemistry 1999;274(50):35832-9.
1999: Ryuichi Tozawa; Shun Ishibashi; Jun-ichi Osuga; Hiroaki Yagyu; Toru Oka; Z Chen; Ken Ohashi; S Perrey; Futoshi Shionoiri; Naoya Yahagi; Kenji Harada; Takanari Gotoda; Yoshio Yazaki; Nobuhiro Yamada
Embryonic lethality and defective neural tube closure in mice lacking squalene synthase.
The Journal of biological chemistry 1999;274(43):30843-8.
1999: Ken Ohashi; Shunji Natori; Takeo Kubo
Expression of amylase and glucose oxidase in the hypopharyngeal gland with an age-dependent role change of the worker honeybee (Apis mellifera L.).
European journal of biochemistry / FEBS 1999;265(1):127-33.
1999: Hiroaki Yagyu; Shun Ishibashi; Z Chen; Jun-ichi Osuga; Mitsuyo Okazaki; S Perrey; Tetsuya Kitamine; M Shimada; Ken Ohashi; Kenji Harada; Futoshi Shionoiri; Naoya Yahagi; Takanari Gotoda; Yoshio Yazaki; Nobuhiro Yamada
Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice.
Journal of lipid research 1999;40(9):1677-85.
1998: Ken Ohashi; Shun Ishibashi; Masayuki Yamamoto; Jun-ichi Osuga; Yoshio Yazaki; S Yukawa; Nobuhiro Yamada
A truncated species of apolipoprotein B (B-38.7) in a patient with homozygous hypobetalipoproteinemia associated with diabetes mellitus.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(8):1330-4.
1998: Jun-ichi Osuga; M Yonemoto; Nobuhiro Yamada; Hitoshi Shimano; Hiroaki Yagyu; Ken Ohashi; Kenji Harada; T Kamei; Yoshio Yazaki; Shun Ishibashi
Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.
The Journal of clinical investigation 1998;102(2):386-94.
1998: L Sun; Shun Ishibashi; Jun-ichi Osuga; Kenji Harada; Ken Ohashi; Takanari Gotoda; Y Fukuo; Yoshio Yazaki; Nobuhiro Yamada
Clinical features associated with the homozygous Trp64Arg mutation of the beta3-adrenergic receptor: no evidence for its association with obesity in Japanese.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(6):941-6.
1998: Azusa Kamikouchi; Hideaki Takeuchi; Miyuki Sawata; Ken Ohashi; Shunji Natori; Takeo Kubo
Preferential expression of the gene for a putative inositol 1,4,5-trisphosphate receptor homologue in the mushroom bodies of the brain of the worker honeybee Apis mellifera L.
Biochemical and biophysical research communications 1998;242(1):181-6.
1998: Ken Ohashi
[Abetalipoproteinemia].
Ryōikibetsu shōkōgun shirīzu 1998;(19 Pt 2):80-3.
1997: Kenji Harada; Z Chen; Shun Ishibashi; Jun-ichi Osuga; Hiroaki Yagyu; Ken Ohashi; Naoya Yahagi; Futoshi Shionoiri; L Sun; Yoshio Yazaki; Nobuhiro Yamada
Apoptotic cell death in atherosclerotic plaques of hyperlipidemic knockout mice.
Atherosclerosis 1997;135(2):235-9.
1997: Ken Ohashi; Shunji Natori; Takeo Kubo
Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L.
European journal of biochemistry / FEBS 1997;249(3):797-802.
1997: Jun-ichi Osuga; H Yagyu; Ken Ohashi; Kenji Harada; Yoshio Yazaki; Nobuhiro Yamada; Shun Ishibashi
Effects of apo E deficiency on plasma lipid levels in mice lacking APOBEC-1.
Biochemical and biophysical research communications 1997;236(2):375-8.
1997: Kenji Harada; Shun Ishibashi; T Miyashita; Jun-ichi Osuga; H Yagyu; Ken Ohashi; Yoshio Yazaki; Nobuhiro Yamada
Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway.
FEBS letters 1997;411(1):63-6.
1996: T Inaba; Shun Ishibashi; K Harada; Jun-ichi Osuga; Hiroaki Yagyu; Ken Ohashi; Y Yazaki; Nobuhiro Yamada
Synergistic effects of transforming growth factor-beta on the expression of c-fms, macrophage colony-stimulating factor receptor gene, in vascular smooth muscle cells.
FEBS letters 1996;399(3):207-10.
1996: T Inaba; Shun Ishibashi; K Harada; J Ohsuga; Ken Ohashi; Hiroaki Yagyu; Y Yazaki; S Higashiyama; S Kawata; Yuji Matsuzawa; Nobuhiro Yamada
Induction of macrophage colony-stimulating factor receptor (c-fms) expression in vascular medial smooth muscle cells treated with heparin binding epidermal growth factor-like growth factor.
The Journal of biological chemistry 1996;271(40):24413-7.
1996: Shun Ishibashi; S Perrey; Z Chen; Jun-ichi Osuga; Mitsuo Shimada; Ken Ohashi; K Harada; Y Yazaki; Nobuhiro Yamada
Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both.
The Journal of biological chemistry 1996;271(37):22422-7.
1996: Mitsuo Shimada; Shun Ishibashi; T Inaba; Hiroaki Yagyu; K Harada; Jun-ichi Osuga; Ken Ohashi; Y Yazaki; Nobuhiro Yamada
Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7242-6.
1996: Yousuke Seyama; H Otsuka; Ken Ohashi; Berthe Vivien-Roels; Pevet P
Sexual diversity of the lipid metabolism in the Harderian gland of the golden hamster.
Microscopy research and technique 1996;34(1):71-6.
1996: T Inaba; Takanari Gotoda; Shun Ishibashi; K Harada; J I Ohsuga; Ken Ohashi; Y Yazaki; Nobuhiro Yamada
Transcription factor PU.1 mediates induction of c-fms in vascular smooth muscle cells: a mechanism for phenotypic change to phagocytic cells.
Molecular and cellular biology 1996;16(5):2264-73.
1996: Ken Ohashi; Miyuki Sawata; Hideaki Takeuchi; Shunji Natori; Takeo Kubo
Molecular cloning of cDNA and analysis of expression of the gene for alpha-glucosidase from the hypopharyngeal gland of the honeybee Apis mellifera L.
Biochemical and biophysical research communications 1996;221(2):380-5.
1996: Takeo Kubo; M Sasaki; J Nakamura; H Sasagawa; Ken Ohashi; Hideaki Takeuchi; Shunji Natori
Change in the expression of hypopharyngeal-gland proteins of the worker honeybees (Apis mellifera L.) with age and/or role.
Journal of biochemistry 1996;119(2):291-5.
1995: Yousuke Seyama; H Otsuka; Ken Ohashi; Berthe Vivien-Roels; Pevet P
Sexual dimorphism of lipids in Harderian glands of golden hamsters.
Journal of biochemistry 1995;117(3):661-70.