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Hajime Ohigashi

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Co-Publications
Name
90
Murakami, Akira
49
Koshimizu, Koichi
27
Irie, Kazuhiro
27
Nakamura, Yoshimasa
10
Jiwajinda, Suratwadee
10
Hirai, Nobuhiro
10
Hara, Akira
10
Tanaka, Takuji
9
Kim, Ha Won
9
Murakami, Kazuma
9
Mori, Hideki
8
Nakagawa, Yu
8
Shimizu, Takahiko
8
Shirasawa, Takuji
8
Takahashi, Daisuke

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Publications

TOP 3
Yasuda Michiko; Nishizawa Takashi; Ohigashi Hajime; Tanaka Takuji; Hou De-Xing; Colburn Nancy H; Murakami Akira
Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction.
Ikeda Yasutaka; Murakami Akira; Ohigashi Hajime
Strain differences regarding susceptibility to ursolic acid-induced interleukin-1beta release in murine macrophages.
Miyamoto Shingo; Yasui Yumiko; Tanaka Takuji; Ohigashi Hajime; Murakami Akira
Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice.

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All Publications

2009: Yasuda Michiko; Nishizawa Takashi; Ohigashi Hajime; Tanaka Takuji; Hou De-Xing; Colburn Nancy H; Murakami Akira
Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction.
Carcinogenesis 2009;30(7):1209-16.
2008: Ikeda Yasutaka; Murakami Akira; Ohigashi Hajime
Strain differences regarding susceptibility to ursolic acid-induced interleukin-1beta release in murine macrophages.
Life sciences 2008;83(1-2):43-9.
2008: Miyamoto Shingo; Yasui Yumiko; Tanaka Takuji; Ohigashi Hajime; Murakami Akira
Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice.
Carcinogenesis 2008;29(5):1057-63.
2008: Kaneko Kazuyoshi; Akuta Teruo; Sawa Tomohiro; Kim Ha Won; Fujii Shigemoto; Okamoto Tatsuya; Nakayama Hitoshi; Ohigashi Hajime; Murakami Akira; Akaike Takaaki
Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells.
Cancer letters 2008;262(2):239-47.
2008: Ikeda Yasutaka; Murakami Akira; Ohigashi Hajime
Ursolic acid: an anti- and pro-inflammatory triterpenoid.
Molecular nutrition & food research 2008;52(1):26-42.
2008: Kuki Wataru; Hosotani Keisuke; Ohigashi Hajime; Murakami Akira
Metabolism and absorption of auraptene (7-geranyloxylcoumarin) in male SD rats: comparison with 7-ethoxycoumarin.
Nutrition and cancer 2008;60(3):368-72.
2007: Murakami Kazuma; Hara Hideyuki; Masuda Yuichi; Ohigashi Hajime; Irie Kazuhiro
Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40.
Chembiochem : a European journal of chemical biology 2007;8(18):2308-14.
2007: Murakami Akira; Ohigashi Hajime
Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals.
International journal of cancer. Journal international du cancer 2007;121(11):2357-63.
2007: Irie K; Murakami K; Masuda Y; Morimoto A; Ohigashi H; Hara H; Ohashi R; Takegoshi K; Fukuda H; Nagao M; Shimizu T; Shirasawa T
The toxic conformation of the 42-residue amyloid beta peptide and its relevance to oxidative stress in Alzheimer's disease.
Mini reviews in medicinal chemistry 2007;7(10):1001-8.
2007: Kim Mihye; Murakami Akira; Ohigashi Hajime
Modifying effects of dietary factors on (-)-epigallocatechin-3-gallate-induced pro-matrix metalloproteinase-7 production in HT-29 human colorectal cancer cells.
Bioscience, biotechnology, and biochemistry 2007;71(10):2442-50.
2007: Kwon Ki Han; Ohigashi Hajime; Murakami Akira
Dextran sulfate sodium enhances interleukin-1 beta release via activation of p38 MAPK and ERK1/2 pathways in murine peritoneal macrophages.
Life sciences 2007;81(5):362-71.
2007: Eguchi Ai; Kaneko Yuki; Murakami Akira; Ohigashi Hajime
Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.
Bioscience, biotechnology, and biochemistry 2007;71(4):935-45.
2007: Ikeda Yasutaka; Murakami Akira; Fujimura Yoshinori; Tachibana Hirofumi; Yamada Koji; Masuda Daisaku; Hirano Ken-Ichi; Yamashita Shizuya; Ohigashi Hajime
Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4854-64.
2007: Eguchi Ai; Murakami Akira; Li Shiming; Ho Chi-Tang; Ohigashi Hajime
Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.
BioFactors (Oxford, England) 2007;31(2):107-16.
2007: Murakami Akira; Song Meiyu; Katsumata Shin-Ichi; Uehara Mariko; Suzuki Kazuharu; Ohigashi Hajime
Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation.
BioFactors (Oxford, England) 2007;30(3):179-92.
2007: Murakami Akira; Song Meiyu; Ohigashi Hajime
Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages.
BioFactors (Oxford, England) 2007;30(1):1-11.
2006: Kawabata Kyuichi; Murakami Akira; Ohigashi Hajime
Auraptene decreases the activity of matrix metalloproteinases in dextran sulfate sodium-induced ulcerative colitis in ICR mice.
Bioscience, biotechnology, and biochemistry 2006;70(12):3062-5.
2006: Kawabata Kyuichi; Murakami Akira; Ohigashi Hajime
Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism.
FEBS letters 2006;580(22):5288-94.
2006: Eguchi Ai; Murakami Akira; Ohigashi Hajime
Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.
FEBS letters 2006;580(13):3321-8.
2006: Nakagawa Yu; Irie Kazuhiro; Yanagita Ryo C; Ohigashi Hajime; Tsuda Ken-ichiro; Kashiwagi Kaori; Saito Naoaki
Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta.
Journal of medicinal chemistry 2006;49(9):2681-8.
2006: Miyamoto Shingo; Kohno Hiroyuki; Suzuki Rikako; Sugie Shigeyuki; Murakami Akira; Ohigashi Hajime; Tanaka Takuji
Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats.
Oncology reports 2006;15(5):1169-73.
2006: Ikeda Yasutaka; Murakami Akira; Nishizawa Takashi; Ohigashi Hajime
Ursolic acid enhances cyclooxygenases and tumor necrosis factor-alpha expression in mouse skin.
Bioscience, biotechnology, and biochemistry 2006;70(4):1033-7.
2006: Murakami Akira; Ohigashi Hajime
Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells.
Biological chemistry 2006;387(4):387-92.
2005: Murakami Akira; Shigemori Tomohiro; Ohigashi Hajime
Zingiberaceous and citrus constituents, 1'-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action.
The Journal of nutrition 2005;135(12 Suppl):2987S-2992S.
2005: Eguchi Ai; Murakami Akira; Ohigashi Hajime
Novel bioassay system for evaluating anti-oxidative activities of food items: use of basolateral media from differentiated Caco-2 cells.
Free radical research 2005;39(12):1367-75.
2005: Masuda Yuichi; Irie Kazuhiro; Murakami Kazuma; Ohigashi Hajime; Ohashi Ryutaro; Takegoshi K; Shimizu Takahiko; Shirasawa Takuji
Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.
Bioorganic & medicinal chemistry 2005;13(24):6803-9.
2005: Kim Ha Won; Murakami Akira; Abe Masako; Ozawa Yoshio; Morimitsu Yasujiro; Williams Marshall V; Ohigashi Hajime
Suppressive effects of mioga ginger and ginger constituents on reactive oxygen and nitrogen species generation, and the expression of inducible pro-inflammatory genes in macrophages.
Antioxidants & redox signaling 2005;7(11-12):1621-9.
2005: Murakami Kazuma; Irie Kazuhiro; Ohigashi Hajime; Hara Hideyuki; Nagao Masaya; Shimizu Takahiko; Shirasawa Takuji
Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease.
Journal of the American Chemical Society 2005;127(43):15168-74.
2005: Kwon Ki Han; Murakami Akira; Hayashi Ryohei; Ohigashi Hajime
Interleukin-1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis.
Biochemical and biophysical research communications 2005;337(2):647-54.
2005: Ikeda Yasutaka; Murakami Akira; Ohigashi Hajime
Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages.
Biochemical pharmacology 2005;70(10):1497-505.
2005: Murakami Akira; Nishizawa Takashi; Egawa Kahori; Kawada Teruo; Nishikawa Yasushi; Uenakai Kazuo; Ohigashi Hajime
New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARgamma-, dependent pathways in stimulated macrophages.
Biochemical pharmacology 2005;70(9):1330-42.
2005: Murakami Akira; Ishida Hisashi; Kobo Kimie; Furukawa Ikuyo; Ikeda Yasutaka; Yonaha Megumi; Aniya Yohko; Ohigashi Hajime
Suppressive effects of Okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammation-associated carcinogenesis.
Asian Pacific journal of cancer prevention : APJCP 2005;6(4):437-48.
2005: Kim Mihye; Murakami Akira; Kawabata Kyuichi; Ohigashi Hajime
(-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells.
Carcinogenesis 2005;26(9):1553-62.
2005: Inomata Masahiro; Hirai Nobuhiro; Takeda Naohito; Ohigashi Hajime
Mechanism of the formation of a dehydrated ion by an unusual loss of oxygen at the 4'-carbonyl group of abscisic acid methyl ester in electron ionization mass spectrometry.
Journal of mass spectrometry : JMS 2005;40(8):1035-43.
2005: Irie Kazuhiro; Murakami Kazuma; Masuda Yuichi; Morimoto Akira; Ohigashi Hajime; Ohashi Ryutaro; Takegoshi Kiyonori; Nagao Masaya; Shimizu Takahiko; Shirasawa Takuji
Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.
Journal of bioscience and bioengineering 2005;99(5):437-47.
2005: Nakagawa Yu; Irie Kazuhiro; Yanagita Ryo C; Ohigashi Hajime; Tsuda Ken-Ichiro
Indolactam-V is involved in the CH/pi interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand.
Journal of the American Chemical Society 2005;127(16):5746-7.
2005: Kawabata Kyuichi; Murakami Akira; Ohigashi Hajime
Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells.
Bioscience, biotechnology, and biochemistry 2005;69(2):307-14.
2005: Kwon Ki Han; Murakami Akira; Tanaka Takuji; Ohigashi Hajime
Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression.
Biochemical pharmacology 2005;69(3):395-406.
2005: Irie Kazuhiro; Nakagawa Yu; Ohigashi Hajime
Toward the development of new medicinal leads with selectivity for protein kinase C isozymes.
Chemical record (New York, N.Y.) 2005;5(4):185-95.
2004: Inomata Masahiro; Hirai Nobuhiro; Yoshida Ryuji; Ohigashi Hajime
Biosynthesis of abscisic acid by the direct pathway via ionylideneethane in a fungus, Cercospora cruenta.
Bioscience, biotechnology, and biochemistry 2004;68(12):2571-80.
2004: Morimoto Akira; Irie Kazuhiro; Murakami Kazuma; Masuda Yuichi; Ohigashi Hajime; Nagao Masaya; Fukuda Hiroyuki; Shimizu Takahiko; Shirasawa Takuji
Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.
The Journal of biological chemistry 2004;279(50):52781-8.
2004: Inomata Masahiro; Hirai Nobuhiro; Yoshida Ryuji; Ohigashi Hajime
The biosynthetic pathway to abscisic acid via ionylideneethane in the fungus Botrytis cinerea.
Phytochemistry 2004;65(19):2667-78.
2004: Irie Kazuhiro; Masuda Akiko; Shindo Mayumi; Nakagawa Yu; Ohigashi Hajime
Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s.
Bioorganic & medicinal chemistry 2004;12(17):4575-83.
2004: Murakami Akira; Tanaka Takuji; Lee Ji-Yoon; Surh Young-Joon; Kim Ha Won; Kawabata Kyuichi; Nakamura Yoshimasa; Jiwajinda Suratwadee; Ohigashi Hajime
Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice.
International journal of cancer. Journal international du cancer 2004;110(4):481-90.
2004: Saito Shigeki; Hirai Nobuhiro; Matsumoto Chiaki; Ohigashi Hajime; Ohta Daisaku; Sakata Kanzo; Mizutani Masaharu
Arabidopsis CYP707As encode (+)-abscisic acid 8'-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid.
Plant physiology 2004;134(4):1439-49.
2004: Kwon Ki Han; Murakami Akira; Ohigashi Hajime
Suppressive effects of natural and synthetic agents on dextran sulfate sodium-induced interleukin-1beta release from murine peritoneal macrophages.
Bioscience, biotechnology, and biochemistry 2004;68(2):436-9.
2004: Kim Ha Won; Murakami Akira; Williams Marshall V; Ohigashi Hajime
Suppressive effects of selected antioxidants on the activated leukocytes-induced mutagenesis in the co-culture assay systems.
Bioscience, biotechnology, and biochemistry 2004;68(1):238-42.
2004: Ohigashi Hajime; Murakami Akira
Cancer prevention with food factors: alone and in combination.
BioFactors (Oxford, England) 2004;22(1-4):49-55.
2004: Murakami Akira; Miyamoto Masaaki; Ohigashi Hajime
Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines.
BioFactors (Oxford, England) 2004;21(1-4):95-101.
2004: Kwon K H; Murakami A; Tanaka T; Ohigashi H
Suppressive activity of a fermented grain food product on dextran sulfate sodium-induced experimental colitis in mice.
BioFactors (Oxford, England) 2004;21(1-4):179-84.
2004: Shimoji Yumi; Kohno Hiroyuki; Nanda Kumiko; Nishikawa Yasushi; Ohigashi Hajime; Uenakai Kazuo; Tanaka Takuji
Extract of Kurosu, a vinegar from unpolished rice, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats.
Nutrition and cancer 2004;49(2):170-3.
2004: Sakata Keiko; Hara Akira; Hirose Yoshinobu; Yamada Yasuhiro; Kuno Toshiya; Katayama Masaki; Yoshida Koujiro; Zheng Qiao; Murakami Akira; Ohigashi Hajime; Ikemoto Kohei; Koshimizu Koichi; Tanaka Takuji; Mori Hideki
Dietary supplementation of the citrus antioxidant auraptene inhibits N,N-diethylnitrosamine-induced rat hepatocarcinogenesis.
Oncology 2004;66(3):244-52.
2004: Irie Kazuhiro; Nakagawa Yu; Ohigashi Hajime
Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes.
Current pharmaceutical design 2004;10(12):1371-85.
2003: Shimoji Y; Sugie S; Kohno H; Tanaka T; Nanda K; Tamura Y; Nishikawa Y; Hayashi R; Uenakai K; Ohigashi H
Extract of vinegar "Kurosu" from unpolished rice inhibits the development of colonic aberrant crypt foci induced by azoxymethane.
Journal of experimental & clinical cancer research : CR 2003;22(4):591-7.
2003: Hirai Nobuhiro; Kondo Satoru; Ohigashi Hajime
Deuterium-labeled phaseic acid and dihydrophaseic acids for internal standards.
Bioscience, biotechnology, and biochemistry 2003;67(11):2408-15.
2003: Murakami Kazuma; Irie Kazuhiro; Morimoto Akira; Ohigashi Hajime; Shindo Mayumi; Nagao Masaya; Shimizu Takahiko; Shirasawa Takuji
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.
The Journal of biological chemistry 2003;278(46):46179-87.
2003: Murakami Akira; Hayashi Ryohei; Tanaka Takuji; Kwon Ki Han; Ohigashi Hajime; Safitri Ratu;
Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination.
Biochemical pharmacology 2003;66(7):1253-61.
2003: Nakagawa Yu; Irie Kazuhiro; Yamanaka Nobuhiro; Ohigashi Hajime; Tsuda Ken-ichiro
Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes.
Bioorganic & medicinal chemistry letters 2003;13(18):3015-9.
2003: Murakami Akira; Takahashi Daisuke; Hagihara Kazuma; Koshimizu Koichi; Ohigashi Hajime
Combinatorial effects of nonsteroidal anti-inflammatory drugs and food constituents on production of prostaglandin E2 and tumor necrosis factor-alpha in RAW264.7 murine macrophages.
Bioscience, biotechnology, and biochemistry 2003;67(5):1056-62.
2003: Murakami Akira; Matsumoto Kazuhiko; Koshimizu Koichi; Ohigashi Hajime
Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages.
Cancer letters 2003;195(1):17-25.
2003: Murakami Akira; Takahashi Daisuke; Koshimizu Koichi; Ohigashi Hajime
Synergistic suppression of superoxide and nitric oxide generation from inflammatory cells by combined food factors.
Mutation research 2003;523-524():151-61.
2003: Kim Ha Won; Murakami Akira; Williams Marshall V; Ohigashi Hajime
Mutagenicity of reactive oxygen and nitrogen species as detected by co-culture of activated inflammatory leukocytes and AS52 cells.
Carcinogenesis 2003;24(2):235-41.
2002: Zheng Qiao; Hirose Yoshinobu; Yoshimi Naoki; Murakami Akira; Koshimizu Koichi; Ohigashi Hajime; Sakata Keiko; Matsumoto Yuji; Sayama Yoshikatsu; Mori Hideki
Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells.
Journal of cancer research and clinical oncology 2002;128(10):539-46.
2002: Shimoji Yumi; Tamura Yoshitaka; Nakamura Yoshimasa; Nanda Kumiko; Nishidai Shoko; Nishikawa Yasushi; Ishihara Nobuhiro; Uenakai Kazuo; Ohigashi Hajime
Isolation and identification of DPPH radical scavenging compounds in Kurosu (Japanese unpolished rice vinegar).
Journal of agricultural and food chemistry 2002;50(22):6501-3.
2002: Jiwajinda Suratwadee; Santisopasri Vilai; Murakami Akira; Sugiyama Hiromu; Gasquet Monique; Riad Elias; Balansard Guy; Ohigashi Hajime
In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.
Journal of ethnopharmacology 2002;82(1):55-8.
2002: Masuda Akiko; Irie Kazuhiro; Nakagawa Yu; Ohigashi Hajime
Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes.
Bioscience, biotechnology, and biochemistry 2002;66(7):1615-7.
2002: Morimoto Akira; Irie Kazuhiro; Murakami Kazuma; Ohigashi Hajime; Shindo Mayumi; Nagao Masaya; Shimizu Takahiko; Shirasawa Takuji
Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23.
Biochemical and biophysical research communications 2002;295(2):306-11.
2002: Murakami Akira; Nakamura Yoshimasa; Koshimizu Koichi; Takahashi Daisuke; Matsumoto Kazuhiro; Hagihara Kazuma; Taniguchi Hisaji; Nomura Eisaku; Hosoda Asao; Tsuno Takuo; Maruta Yuko; Kim Ha Won; Kawabata Kyuichi; Ohigashi Hajime
FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: comparison with ferulic acid.
Cancer letters 2002;180(2):121-9.
2002: Hosoda Asao; Nomura Eisaku; Murakami Akira; Koshimizu Koichi; Ohigashi Hajime; Mizuno Kazuhiko; Taniguchi Hisaji
Synthesis of feruloyl-myo-insitol derivatives and their inhibitory effects on phorbol ester-induced superoxide generation and Esptein-Barr virus activation.
Bioorganic & medicinal chemistry 2002;10(6):1855-63.
2002: Murakami Kazuma; Irie Kazuhiro; Morimoto Akira; Ohigashi Hajime; Shindo Mayumi; Nagao Masaya; Shimizu Takahiko; Shirasawa Takuji
Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.
Biochemical and biophysical research communications 2002;294(1):5-10.
2002: Murakami Akira; Takahashi Daisuke; Kinoshita Takashi; Koshimizu Koichi; Kim Ha Won; Yoshihiro Akira; Nakamura Yoshimasa; Jiwajinda Suratwadee; Terao Junji; Ohigashi Hajime
Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.
Carcinogenesis 2002;23(5):795-802.
2002: Nomura Eisaku; Hosoda Asao; Morishita Hideko; Murakami Akira; Koshimizu Koichi; Ohigashi Hajime; Taniguchi Hisaji
Synthesis of novel polyphenols consisted of ferulic and gallic acids, and their inhibitory effects on phorbol ester-induced Epstein-Barr virus activation and superoxide generation.
Bioorganic & medicinal chemistry 2002;10(4):1069-75.
2002: Irie Kazuhiro; Nakahara Akifumi; Nakagawa Yu; Ohigashi Hajime; Shindo Mayumi; Fukuda Hiroyuki; Konishi Hiroaki; Kikkawa Ushio; Kashiwagi Kaori; Saito Naoaki
Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity.
Pharmacology & therapeutics 2002;93(2-3):271-81.
2002: Kim Ha Won; Murakami Akira; Nakamura Yoshimasa; Ohigashi Hajime
Screening of edible Japanese plants for suppressive effects on phorbol ester-induced superoxide generation in differentiated HL-60 cells and AS52 cells.
Cancer letters 2002;176(1):7-16.
2002: Murakami Akira; Koshimizu Koichi; Ohigashi Hajime; Kuwahara Shigeru; Kuki Wataru; Takahashi Yasuo; Hosotani Keisuke; Kawahara Satsuki; Matsuoka Yumi
Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin.
BioFactors (Oxford, England) 2002;16(3-4):73-82.
2001: Jiwajinda S; Santisopasri V; Murakami A; Hirai N; Ohigashi H
Quassinoids from Eurycoma longifolia as plant growth inhibitors.
Phytochemistry 2001;58(6):959-62.
2001: Shindo M; Irie K; Nakahara A; Ohigashi H; Konishi H; Kikkawa U; Fukuda H; Wender P A
Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding.
Bioorganic & medicinal chemistry 2001;9(8):2073-81.
2001: Nakamura Y; Torikai K; Ohigashi H
A catechol antioxidant protocatechuic acid potentiates inflammatory leukocyte-derived oxidative stress in mouse skin via a tyrosinase bioactivation pathway.
Free radical biology & medicine 2001;30(9):967-78.
2001: Jiwajinda S; Hirai N; Watanabe K; Santisopasri V; Chuengsamarnyart N; Koshimizu K; Ohigashi H
Occurrence of the insecticidal 16,17-didehydro-16(E)-stemofoline in Stemona collinsae.
Phytochemistry 2001;56(7):693-5.
2001: Nakagawa Y; Irie K; Nakamura Y; Ohigashi H
The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities.
Bioorganic & medicinal chemistry letters 2001;11(5):723-8.
2001: Tanaka M; Irie K; Nakagawa Y; Nakamura Y; Ohigashi H; Wender P A
The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding.
Bioorganic & medicinal chemistry letters 2001;11(5):719-22.
2001: Lahlou E H; Hirai N; Kamo T; Tsuda M; Ohigashi H
Actinidic acid, a new triterpene phytoalexin from unripe kiwi fruit.
Bioscience, biotechnology, and biochemistry 2001;65(2):480-3.
2000: Kim O K; Murakami A; Takahashi D; Nakamura Y; Torikai K; Kim H W; Ohigashi H
An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin.
Bioscience, biotechnology, and biochemistry 2000;64(11):2504-7.
2000: Irie K; Nakahara A; Ikawa Y; Tanaka M; Nakagawa Y; Nakamura Y; Ohigashi H; Wender P A
Synthesis and tumor-promoting activities of 12-Epi-phorbol-12,13-dibutyrate.
Bioscience, biotechnology, and biochemistry 2000;64(11):2429-36.
2000: Murakami A; Kawabata K; Koshiba T; Gao G; Nakamura Y; Koshimizu K; Ohigashi H
Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha.
Cancer research 2000;60(22):6326-31.
2000: Kamo T; Hirai N; Tsuda M; Fujioka D; Ohigashi H
Changes in the content and biosynthesis of phytoalexins in banana fruit.
Bioscience, biotechnology, and biochemistry 2000;64(10):2089-98.
2000: Nakamura Y; Torikai K; Ohto Y; Murakami A; Tanaka T; Ohigashi H
A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: dose-and timing-dependent enhancement and involvement of bioactivation by tyrosinase.
Carcinogenesis 2000;21(10):1899-907.
2000: Murakami A; Nakamura Y; Tanaka T; Kawabata K; Takahashi D; Koshimizu K; Ohigashi H
Suppression by citrus auraptene of phorbol ester-and endotoxin-induced inflammatory responses: role of attenuation of leukocyte activation.
Carcinogenesis 2000;21(10):1843-50.
2000: Hirai N; Sakashita S; Sano T; Inoue T; Ohigashi H; Premasthira C; Asakawa Y; Harada J; Fujii Y
Allelochemicals of the tropical weed Sphenoclea zeylanica.
Phytochemistry 2000;55(2):131-40.
2000: Murakami A; Nakamura Y; Torikai K; Tanaka T; Koshiba T; Koshimizu K; Kuwahara S; Takahashi Y; Ogawa K; Yano M; Tokuda H; Nishino H; Mimaki Y; Sashida Y; Kitanaka S; Ohigashi H
Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice.
Cancer research 2000;60(18):5059-66.
2000: Nakagawa Y; Irie K; Ohigashi H; Hayashi H; Wender P A
Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V.
Bioorganic & medicinal chemistry letters 2000;10(18):2087-90.
2000: Nakamura Y; Morimitsu Y; Uzu T; Ohigashi H; Murakami A; Naito Y; Nakagawa Y; Osawa T; Uchida K
A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates.
Cancer letters 2000;157(2):193-200.
2000: Hirai N; Sugie M; Wada M; Lahlou E H; Kamo T; Yoshida R; Tsuda M; Ohigashi H
Triterpene phytoalexins from strawberry fruit.
Bioscience, biotechnology, and biochemistry 2000;64(8):1707-12.
2000: Murakami A; Kadota M; Takahashi D; Taniguchi H; Nomura E; Hosoda A; Tsuno T; Maruta Y; Ohigashi H; Koshimizu K
Suppressive effects of novel ferulic acid derivatives on cellular responses induced by phorbol ester, and by combined lipopolysaccharide and interferon-gamma.
Cancer letters 2000;157(1):77-85.
2000: Hirai N; Yoshida R; Todoroki Y; Ohigashi H
Biosynthesis of abscisic acid by the non-mevalonate pathway in plants, and by the mevalonate pathway in fungi.
Bioscience, biotechnology, and biochemistry 2000;64(7):1448-58.
2000: Hosoda A; Nomura E; Murakami A; Koshimizu K; Ohigashi H; Mizuno K; Taniguchi H
Synthesis of feruloyl-myo-inositols and their inhibitory effects on superoxide generation.
Bioorganic & medicinal chemistry letters 2000;10(13):1439-42.
2000: Kim O K; Murakami A; Nakamura Y; Takeda N; Yoshizumi H; Ohigashi H
Novel nitric oxide and superoxide generation inhibitors, persenone A and B, from avocado fruit.
Journal of agricultural and food chemistry 2000;48(5):1557-63.
2000: Murakami A; Toyota K; Ohura S; Koshimizu K; Ohigashi H
Structure-activity relationships of (1'S)-1'-acetoxychavicol acetate, a major constituent of a southeast Asian condiment plant Languas galanga, on the inhibition of tumor-promoter-induced Epstein-Barr virus activation.
Journal of agricultural and food chemistry 2000;48(5):1518-23.
2000: Kawabata K; Tanaka T; Yamamoto T; Hara A; Murakami A; Koshimizu K; Ohigashi H; Stoner G D; Mori H
Suppression of N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis by dietary feeding of auraptene.
Journal of experimental & clinical cancer research : CR 2000;19(1):45-52.
2000: Kawabata K; Tanaka T; Yamamoto T; Ushida J; Hara A; Murakami A; Koshimizu K; Ohigashi H; Stoner G D; Mori H
Suppression of N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis by dietary feeding of 1'-acetoxychavicol acetate.
Japanese journal of cancer research : Gann 2000;91(2):148-55.
2000: Murakami A; Nakashima M; Koshiba T; Maoka T; Nishino H; Yano M; Sumida T; Kim O K; Koshimizu K; Ohigashi H
Modifying effects of carotenoids on superoxide and nitric oxide generation from stimulated leukocytes.
Cancer letters 2000;149(1-2):115-23.
2000: Jiwajinda S; Santisopasri V; Ohigashi H
Coumarin-related compounds as plant growth inhibitors from two rutaceous plants in Thailand.
Bioscience, biotechnology, and biochemistry 2000;64(2):420-3.
2000: Murakami A; Ali A M; Mat-Salleh K; Koshimizu K; Ohigashi H
Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia.
Bioscience, biotechnology, and biochemistry 2000;64(1):9-16.
2000: Nakamura Y; Ohigashi H; Masuda S; Murakami A; Morimitsu Y; Kawamoto Y; Osawa T; Imagawa M; Uchida K
Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates.
Cancer research 2000;60(2):219-25.
2000: Murakami A; Gao G; Omura M; Yano M; Ito C; Furukawa H; Takahashi D; Koshimizu K; Ohigashi H
1,1-Dimethylallylcoumarins potently suppress both lipopolysaccharide- and interferon-gamma-induced nitric oxide generation in mouse macrophage RAW 264.7 cells.
Bioorganic & medicinal chemistry letters 2000;10(1):59-62.
2000: Murakami A; Nakamura Y; Ohto Y; Yano M; Koshiba T; Koshimizu K; Tokuda H; Nishino H; Ohigashi H
Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid.
BioFactors (Oxford, England) 2000;12(1-4):187-92.
2000: Murakami A; Wada K; Ueda N; Sasaki K; Haga M; Kuki W; Takahashi Y; Yonei H; Koshimizu K; Ohigashi H
In vitro absorption and metabolism of a citrus chemopreventive agent, auraptene, and its modifying effects on xenobiotic enzyme activities in mouse livers.
Nutrition and cancer 2000;36(2):191-9.
1999: Murakami A; Takahashi M; Jiwajinda S; Koshimizu K; Ohigashi H
Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation.
Bioscience, biotechnology, and biochemistry 1999;63(10):1811-2.
1999: Irie K; Nakahara A; Ohigashi H; Fukuda H; Wender P A; Konishi H; Kikkawa U
Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D.
Bioorganic & medicinal chemistry letters 1999;9(17):2487-90.
1999: Tanaka T; Sugiura H; Inaba R; Nishikawa A; Murakami A; Koshimizu K; Ohigashi H
Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice.
Carcinogenesis 1999;20(8):1471-6.
1999: Nakamura Y; Kawamoto N; Ohto Y; Torikai K; Murakami A; Ohigashi H
A diacetylenic spiroketal enol ether epoxide, AL-1, from Artemisia lactiflora inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion possibly by suppression of oxidative stress.
Cancer letters 1999;140(1-2):37-45.
1999: Murakami A; Gao G; Kim O K; Omura M; Yano M; Ito C; Furukawa H; Jiwajinda S; Koshimizu K; Ohigashi H
Identification of coumarins from the fruit of Citrus hystrix DC as inhibitors of nitric oxide generation in mouse macrophage RAW 264.7 cells.
Journal of agricultural and food chemistry 1999;47(1):333-9.
1998: Nakamura Y; Murakami A; Ohto Y; Torikai K; Tanaka T; Ohigashi H
Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1'-acetoxychavicol acetate.
Cancer research 1998;58(21):4832-9.
1998: Nakagawa Y; Irie K; Nakamura Y; Ohigashi H; Hayashi H
Synthesis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V.
Bioscience, biotechnology, and biochemistry 1998;62(8):1568-73.
1998: Tanaka T; Kawabata K; Kakumoto M; Hara A; Murakami A; Kuki W; Takahashi Y; Yonei H; Maeda M; Ota T; Odashima S; Yamane T; Koshimizu K; Ohigashi H
Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes.
Cancer research 1998;58(12):2550-6.
1998: Murakami A; Kitazono Y; Jiwajinda S; Koshimizu K; Ohigashi H
Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein-Barr virus activation.
Planta medica 1998;64(4):319-23.
1998: Nakamura Y; Ohto Y; Murakami A; Osawa T; Ohigashi H
Inhibitory effects of curcumin and tetrahydrocurcuminoids on the tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo.
Japanese journal of cancer research : Gann 1998;89(4):361-70.
1998: Kim O K; Murakami A; Nakamura Y; Ohigashi H
Screening of edible Japanese plants for nitric oxide generation inhibitory activities in RAW 264.7 cells.
Cancer letters 1998;125(1-2):199-207.
1998: Tanaka T; Kawabata K; Kakumoto M; Matsunaga K; Mori H; Murakami A; Kuki W; Takahashi Y; Yonei H; Satoh K; Hara A; Maeda M; Ota T; Odashima S; Koshimizu K; Ohigashi H
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats.
Carcinogenesis 1998;19(3):425-31.
1998: Murakami A; Morita H; Safitri R; Ramlan A; Koshimizu K; Ohigashi H
Screening for in vitro anti-tumor-promoting activities of edible plants from Indonesia.
Cancer detection and prevention 1998;22(6):516-25.
1997: Tanaka T; Kawabata K; Kakumoto M; Makita H; Hara A; Mori H; Satoh K; Hara A; Murakami A; Kuki W; Takahashi Y; Yonei H; Koshimizu K; Ohigashi H
Citrus auraptene inhibits chemically induced colonic aberrant crypt foci in male F344 rats.
Carcinogenesis 1997;18(11):2155-61.
1997: Tanaka T; Kawabata K; Kakumoto M; Makita H; Matsunaga K; Mori H; Satoh K; Hara A; Murakami A; Koshimizu K; Ohigashi H
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate.
Japanese journal of cancer research : Gann 1997;88(9):821-30.
1997: Irie K; Yanai Y; Oie K; Ishizawa J; Nakagawa Y; Ohigashi H; Wender P A; Kikkawa U
Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase C gamma.
Bioorganic & medicinal chemistry 1997;5(8):1725-37.
1997: Nakagawa Y; Irie K; Nakamura Y; Ohigashi H; Hayashi H
Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V.
Bioscience, biotechnology, and biochemistry 1997;61(8):1415-7.
1997: Murakami A; Kuki W; Takahashi Y; Yonei H; Nakamura Y; Ohto Y; Ohigashi H; Koshimizu K
Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin, possibly through suppression of superoxide generation in leukocytes.
Japanese journal of cancer research : Gann 1997;88(5):443-52.
1997: Tanaka T; Makita H; Kawamori T; Kawabata K; Mori H; Murakami A; Satoh K; Hara A; Ohigashi H; Koshimizu K
A xanthine oxidase inhibitor 1'-acetoxychavicol acetate inhibits azoxymethane-induced colonic aberrant crypt foci in rats.
Carcinogenesis 1997;18(5):1113-8.
1996: Ohigashi H; Murakami A; Koshimizu K
An approach to functional food: cancer preventive potential of vegetables and fruits and their active constituents.
Nutrition reviews 1996;54(11 Pt 2):S24-8.
1996: Nakamura Y; Murakami A; Koshimizu K; Ohigashi H
Inhibitory effect of pheophorbide a, a chlorophyll-related compound, on skin tumor promotion in ICR mouse.
Cancer letters 1996;108(2):247-55.
1996: Murakami A; Ohura S; Nakamura Y; Koshimizu K; Ohigashi H
1'-Acetoxychavicol acetate, a superoxide anion generation inhibitor, potently inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in ICR mouse skin.
Oncology 1996;53(5):386-91.
1996: Irie K; Nakamura Y; Ohigashi H; Tokuyama H; Yamago S; Nakamura E
Photocytotoxicity of water-soluble fullerene derivatives.
Bioscience, biotechnology, and biochemistry 1996;60(8):1359-61.
1996: Nakamura Y; Murakami A; Koshimizu K; Ohigashi H
Identification of pheophorbide a and its related compounds as possible anti-tumor promoters in the leaves of Neptunia oleracea.
Bioscience, biotechnology, and biochemistry 1996;60(6):1028-30.
1996: Ohnishi M; Tanaka T; Makita H; Kawamori T; Mori H; Satoh K; Hara A; Murakami A; Ohigashi H; Koshimizu K
Chemopreventive effect of a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate, on rat oral carcinogenesis.
Japanese journal of cancer research : Gann 1996;87(4):349-56.
1995: Murakami A; Jiwajinda S; Koshimizu K; Ohigashi H
Screening for in vitro anti-tumor promoting activities of edible plants from Thailand.
Cancer letters 1995;95(1-2):139-46.
1994: Koshimizu K; Ohigashi H; Huffman M A
Use of Vernonia amygdalina by wild chimpanzee: possible roles of its bitter and related constituents.
Physiology & behavior 1994;56(6):1209-16.
1993: Jisaka M; Ohigashi H; Takegawa K; Huffman M A; Koshimizu K
Antitumoral and antimicrobial activities of bitter sesquiterpene lactones of Vernonia amygdalina, a possible medicinal plant used by wild chimpanzees.
Bioscience, biotechnology, and biochemistry 1993;57(5):833-4.
1992: Ohigashi H; Sakai Y; Yamaguchi K; Umezaki I; Koshimizu K
Possible anti-tumor promoting properties of marine algae and in vivo activity of Wakame seaweed extract.
Bioscience, biotechnology, and biochemistry 1992;56(6):994-5.
1992: Murakami A; Tanaka S; Ohigashi H; Hirota M; Irie R; Takeda N; Tatematsu A; Koshimizu K
Chalcone tetramers, lophirachalcone and alatachalcone, from Lophira alata as possible anti-tumor promoters.
Bioscience, biotechnology, and biochemistry 1992;56(5):769-72.
1992: Jisaka M; Kawanaka M; Sugiyama H; Takegawa K; Huffman M A; Ohigashi H; Koshimizu K
Antischistosomal activities of sesquiterpene lactones and steroid glucosides from Vernonia amygdalina, possibly used by wild chimpanzees against parasite-related diseases.
Bioscience, biotechnology, and biochemistry 1992;56(5):845-6.
1991: Murakami A; Ohigashi H; Jisaka M; Hirota M; Irie R; Koshimizu K
Inhibitory effects of new types of biflavonoid-related polyphenols; lophirone A and lophiraic acid, on some tumor promoter-induced biological responses in vitro and in vivo.
Cancer letters 1991;58(1-2):101-6.
1991: Hirotani H; Ohigashi H; Kobayashi M; Koshimizu K; Takahashi E
Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols.
FEMS microbiology letters 1991;61(1):13-7.
1988: Koshimizu K; Ohigashi H; Tokuda H; Kondo A; Yamaguchi K
Screening of edible plants against possible anti-tumor promoting activity.
Cancer letters 1988;39(3):247-57.

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