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Hajime Ohigashi

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Akira Murakami; Ikuyo Furukawa; Shingo Miyamoto; Takuji Tanaka; Hajime Ohigashi
Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis.
Nobuhiro Hirai; Mari Horiuchi; Kumiko Iwami; Kenji Kano; Yasushi Todoroki; Hajime Ohigashi
Electrolytic reduction of abscisic acid methyl ester and its free acid.
S Miyamoto; Yumiko Yasui; Hajime Ohigashi; Takuji Tanaka; Akira Murakami
Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.

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2013: Akira Murakami; Ikuyo Furukawa; Shingo Miyamoto; Takuji Tanaka; Hajime Ohigashi
Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis.
BioFactors (Oxford, England) 2013;39(2):221-32.
2012: Nobuhiro Hirai; Mari Horiuchi; Kumiko Iwami; Kenji Kano; Yasushi Todoroki; Hajime Ohigashi
Electrolytic reduction of abscisic acid methyl ester and its free acid.
Phytochemistry 2012;80():89-98.
2010: S Miyamoto; Yumiko Yasui; Hajime Ohigashi; Takuji Tanaka; Akira Murakami
Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.
Chemico-biological interactions 2010;183(2):276-83.
2010: Mihye Kim; Akira Murakami; Shingo Miyamoto; Takuji Tanaka; Hajime Ohigashi
The modifying effects of green tea polyphenols on acute colitis and inflammation-associated colon carcinogenesis in male ICR mice.
BioFactors (Oxford, England) 2010;36(1):43-51.
2009: Michiko Yasuda; Takashi Nishizawa; Hajime Ohigashi; Takuji Tanaka; De-Xing Hou; Nancy H Colburn; Akira Murakami
Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction.
Carcinogenesis 2009;30(7):1209-16.
2008: Yasutaka Ikeda; Akira Murakami; Hajime Ohigashi
Strain differences regarding susceptibility to ursolic acid-induced interleukin-1beta release in murine macrophages.
Life sciences 2008;83(1-2):43-9.
2008: Shingo Miyamoto; Yumiko Yasui; Takuji Tanaka; Hajime Ohigashi; Akira Murakami
Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice.
Carcinogenesis 2008;29(5):1057-63.
2008: Kazuyoshi Kaneko; Teruo Akuta; Tomohiro Sawa; Ha Won Kim; Shigemoto Fujii; Tatsuya Okamoto; Hitoshi Nakayama; Hajime Ohigashi; Akira Murakami; Takaaki Akaike
Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells.
Cancer letters 2008;262(2):239-47.
2008: Wataru Kuki; Keisuke Hosotani; Hajime Ohigashi; Akira Murakami
Metabolism and absorption of auraptene (7-geranyloxylcoumarin) in male SD rats: comparison with 7-ethoxycoumarin.
Nutrition and cancer 2008;60(3):368-72.
2008: Yasutaka Ikeda; Akira Murakami; Hajime Ohigashi
Ursolic acid: an anti- and pro-inflammatory triterpenoid.
Molecular nutrition & food research 2008;52(1):26-42.
2007: Kazuma Murakami; Hideyuki Hara; Yuichi Masuda; Hajime Ohigashi; Kazuhiro Irie
Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40.
Chembiochem : a European journal of chemical biology 2007;8(18):2308-14.
2007: Akira Murakami; Hajime Ohigashi
Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals.
International journal of cancer. Journal international du cancer 2007;121(11):2357-63.
2007: Kazuhiro Irie; Kazuma Murakami; Y Masuda; Akira Morimoto; Hajime Ohigashi; Hideaki Hara; Ryutaro Ohashi; Kiyonori Takegoshi; H Fukuda; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa
The toxic conformation of the 42-residue amyloid beta peptide and its relevance to oxidative stress in Alzheimer's disease.
Mini reviews in medicinal chemistry 2007;7(10):1001-8.
2007: Mihye Kim; Akira Murakami; Hajime Ohigashi
Modifying effects of dietary factors on (-)-epigallocatechin-3-gallate-induced pro-matrix metalloproteinase-7 production in HT-29 human colorectal cancer cells.
Bioscience, biotechnology, and biochemistry 2007;71(10):2442-50.
2007: Ki Han Kwon; Hajime Ohigashi; Akira Murakami
Dextran sulfate sodium enhances interleukin-1 beta release via activation of p38 MAPK and ERK1/2 pathways in murine peritoneal macrophages.
Life sciences 2007;81(5):362-71.
2007: Yasutaka Ikeda; Akira Murakami; Yoshinori Fujimura; Hirofumi Tachibana; Koji Yamada; Daisaku Masuda; Ken-Ichi Hirano; Shizuya Yamashita; Hajime Ohigashi
Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4854-64.
2007: Ai Eguchi; Yuki Kaneko; Akira Murakami; Hajime Ohigashi
Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.
Bioscience, biotechnology, and biochemistry 2007;71(4):935-45.
2007: Ai Eguchi; Akira Murakami; Shiming Li; Chi-Tang Ho; Hajime Ohigashi
Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.
BioFactors (Oxford, England) 2007;31(2):107-16.
2007: Akira Murakami; Meiyu Song; Shin-Ichi Katsumata; Mariko Uehara; Kazuharu Suzuki; Hajime Ohigashi
Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation.
BioFactors (Oxford, England) 2007;30(3):179-92.
2007: Akira Murakami; Meiyu Song; Hajime Ohigashi
Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages.
BioFactors (Oxford, England) 2007;30(1):1-11.
2006: Kyuichi Kawabata; Akira Murakami; Hajime Ohigashi
Auraptene decreases the activity of matrix metalloproteinases in dextran sulfate sodium-induced ulcerative colitis in ICR mice.
Bioscience, biotechnology, and biochemistry 2006;70(12):3062-5.
2006: Kyuichi Kawabata; Akira Murakami; Hajime Ohigashi
Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism.
FEBS letters 2006;580(22):5288-94.
2006: Ai Eguchi; Akira Murakami; Hajime Ohigashi
Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells.
FEBS letters 2006;580(13):3321-8.
2006: Yu Nakagawa; Kazuhiro Irie; Ryo C Yanagita; Hajime Ohigashi; Ken-ichiro Tsuda; Kaori Kashiwagi; Naoaki Saito
Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta.
Journal of medicinal chemistry 2006;49(9):2681-8.
2006: Shingo Miyamoto; Hiroyuki Kohno; Rikako Suzuki; Shigeyuki Sugie; Akira Murakami; Hajime Ohigashi; Takuji Tanaka
Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats.
Oncology reports 2006;15(5):1169-73.
2006: Yasutaka Ikeda; Akira Murakami; Takashi Nishizawa; Hajime Ohigashi
Ursolic acid enhances cyclooxygenases and tumor necrosis factor-alpha expression in mouse skin.
Bioscience, biotechnology, and biochemistry 2006;70(4):1033-7.
2006: Akira Murakami; Hajime Ohigashi
Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells.
Biological chemistry 2006;387(4):387-92.
2005: Yuichi Masuda; Kazuhiro Irie; Kazuma Murakami; Hajime Ohigashi; Ryutaro Ohashi; Kiyonori Takegoshi; Takahiko Shimizu; Takuji Shirasawa
Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.
Bioorganic & medicinal chemistry 2005;13(24):6803-9.
2005: Akira Murakami; Tomohiro Shigemori; Hajime Ohigashi
Zingiberaceous and citrus constituents, 1'-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action.
The Journal of nutrition 2005;135(12 Suppl):2987S-2992S.
2005: Ai Eguchi; Akira Murakami; Hajime Ohigashi
Novel bioassay system for evaluating anti-oxidative activities of food items: use of basolateral media from differentiated Caco-2 cells.
Free radical research 2005;39(12):1367-75.
2005: Ki Han Kwon; Akira Murakami; Ryohei Hayashi; Hajime Ohigashi
Interleukin-1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis.
Biochemical and biophysical research communications 2005;337(2):647-54.
2005: Yasutaka Ikeda; Akira Murakami; Hajime Ohigashi
Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages.
Biochemical pharmacology 2005;70(10):1497-505.
2005: Kazuma Murakami; Kazuhiro Irie; Hajime Ohigashi; Hideyuki Hara; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa
Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease.
Journal of the American Chemical Society 2005;127(43):15168-74.
2005: Ha Won Kim; Akira Murakami; Masako Abe; Yoshio Ozawa; Yasujiro Morimitsu; Marshall V Williams; Hajime Ohigashi
Suppressive effects of mioga ginger and ginger constituents on reactive oxygen and nitrogen species generation, and the expression of inducible pro-inflammatory genes in macrophages.
Antioxidants & redox signaling 2005;7(11-12):1621-9.
2005: Akira Murakami; Takashi Nishizawa; Kahori Egawa; Teruo Kawada; Yasushi Nishikawa; Kazuo Uenakai; Hajime Ohigashi
New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARgamma-, dependent pathways in stimulated macrophages.
Biochemical pharmacology 2005;70(9):1330-42.
2005: Akira Murakami; Hisashi Ishida; Kimie Kobo; Ikuyo Furukawa; Yasutaka Ikeda; Megumi Yonaha; Yohko Aniya; Hajime Ohigashi
Suppressive effects of Okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammation-associated carcinogenesis.
Asian Pacific journal of cancer prevention : APJCP 2005;6(4):437-48.
2005: Mihye Kim; Akira Murakami; Kyuichi Kawabata; Hajime Ohigashi
(-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells.
Carcinogenesis 2005;26(9):1553-62.
2005: Masahiro Inomata; Nobuhiro Hirai; Naohito Takeda; Hajime Ohigashi
Mechanism of the formation of a dehydrated ion by an unusual loss of oxygen at the 4'-carbonyl group of abscisic acid methyl ester in electron ionization mass spectrometry.
Journal of mass spectrometry : JMS 2005;40(8):1035-43.
2005: Kazuhiro Irie; Kazuma Murakami; Yuichi Masuda; Akira Morimoto; Hajime Ohigashi; Ryutaro Ohashi; Kiyonori Takegoshi; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa
Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.
Journal of bioscience and bioengineering 2005;99(5):437-47.
2005: Yu Nakagawa; Kazuhiro Irie; Ryo C Yanagita; Hajime Ohigashi; Ken-Ichiro Tsuda
Indolactam-V is involved in the CH/pi interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand.
Journal of the American Chemical Society 2005;127(16):5746-7.
2005: Kyuichi Kawabata; Akira Murakami; Hajime Ohigashi
Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells.
Bioscience, biotechnology, and biochemistry 2005;69(2):307-14.
2005: Ki Han Kwon; Akira Murakami; Takuji Tanaka; Hajime Ohigashi
Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression.
Biochemical pharmacology 2005;69(3):395-406.
2005: Kazuhiro Irie; Yu Nakagawa; Hajime Ohigashi
Toward the development of new medicinal leads with selectivity for protein kinase C isozymes.
Chemical record (New York, N.Y.) 2005;5(4):185-95.
2004: Akira Morimoto; Kazuhiro Irie; Kazuma Murakami; Yuichi Masuda; Hajime Ohigashi; Masaya Nagao; Hiroyuki Fukuda; Takahiko Shimizu; Takuji Shirasawa
Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.
The Journal of biological chemistry 2004;279(50):52781-8.
2004: Masahiro Inomata; Nobuhiro Hirai; Ryuji Yoshida; Hajime Ohigashi
Biosynthesis of abscisic acid by the direct pathway via ionylideneethane in a fungus, Cercospora cruenta.
Bioscience, biotechnology, and biochemistry 2004;68(12):2571-80.
2004: Masahiro Inomata; Nobuhiro Hirai; Ryuji Yoshida; Hajime Ohigashi
The biosynthetic pathway to abscisic acid via ionylideneethane in the fungus Botrytis cinerea.
Phytochemistry 2004;65(19):2667-78.
2004: Kazuhiro Irie; Akiko Masuda; Mayumi Shindo; Yu Nakagawa; Hajime Ohigashi
Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s.
Bioorganic & medicinal chemistry 2004;12(17):4575-83.
2004: Akira Murakami; Takuji Tanaka; Ji-Yoon Lee; Young-Joon Surh; Ha Won Kim; Kyuichi Kawabata; Yoshimasa Nakamura; Suratwadee Jiwajinda; Hajime Ohigashi
Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice.
International journal of cancer. Journal international du cancer 2004;110(4):481-90.
2004: Shigeki Saito; Nobuhiro Hirai; Chiaki Matsumoto; Hajime Ohigashi; Daisaku Ohta; Kanzo Sakata; Masaharu Mizutani
Arabidopsis CYP707As encode (+)-abscisic acid 8'-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid.
Plant physiology 2004;134(4):1439-49.
2004: Ki Han Kwon; Akira Murakami; Hajime Ohigashi
Suppressive effects of natural and synthetic agents on dextran sulfate sodium-induced interleukin-1beta release from murine peritoneal macrophages.
Bioscience, biotechnology, and biochemistry 2004;68(2):436-9.
2004: Hajime Ohigashi; Akira Murakami
Cancer prevention with food factors: alone and in combination.
BioFactors (Oxford, England) 2004;22(1-4):49-55.
2004: Akira Murakami; Masaaki Miyamoto; Hajime Ohigashi
Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines.
BioFactors (Oxford, England) 2004;21(1-4):95-101.
2004: Ki Han Kwon; Akira Murakami; Takuji Tanaka; Hajime Ohigashi
Suppressive activity of a fermented grain food product on dextran sulfate sodium-induced experimental colitis in mice.
BioFactors (Oxford, England) 2004;21(1-4):179-84.
2004: Yumi Shimoji; Hiroyuki Kohno; Kumiko Nanda; Yasushi Nishikawa; Hajime Ohigashi; Kazuo Uenakai; Takuji Tanaka
Extract of Kurosu, a vinegar from unpolished rice, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats.
Nutrition and cancer 2004;49(2):170-3.
2004: Keiko Sakata; Akira Hara; Yoshinobu Hirose; Yasuhiro Yamada; Toshiya Kuno; Masaki Katayama; Koujiro Yoshida; Qiao Zheng; Akira Murakami; Hajime Ohigashi; Kohei Ikemoto; Koichi Koshimizu; Takuji Tanaka; Hideki Mori
Dietary supplementation of the citrus antioxidant auraptene inhibits N,N-diethylnitrosamine-induced rat hepatocarcinogenesis.
Oncology 2004;66(3):244-52.
2004: Kazuhiro Irie; Yu Nakagawa; Hajime Ohigashi
Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes.
Current pharmaceutical design 2004;10(12):1371-85.
2004: Ha Won Kim; Akira Murakami; Marshall V Williams; Hajime Ohigashi
Suppressive effects of selected antioxidants on the activated leukocytes-induced mutagenesis in the co-culture assay systems.
Bioscience, biotechnology, and biochemistry 2004;68(1):238-42.
2003: Yumi Shimoji; S Sugie; Hiroyuki Kohno; Takuji Tanaka; Kumiko Nanda; Y Tamura; Yasushi Nishikawa; R Hayashi; Kazuo Uenakai; Hajime Ohigashi
Extract of vinegar "Kurosu" from unpolished rice inhibits the development of colonic aberrant crypt foci induced by azoxymethane.
Journal of experimental & clinical cancer research : CR 2003;22(4):591-7.
2003: Kazuma Murakami; Kazuhiro Irie; Akira Morimoto; Hajime Ohigashi; Mayumi Shindo; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.
The Journal of biological chemistry 2003;278(46):46179-87.
2003: Nobuhiro Hirai; Satoru Kondo; Hajime Ohigashi
Deuterium-labeled phaseic acid and dihydrophaseic acids for internal standards.
Bioscience, biotechnology, and biochemistry 2003;67(11):2408-15.
2003: Akira Murakami; Ryohei Hayashi; Takuji Tanaka; Ki Han Kwon; Hajime Ohigashi; Ratu Safitri; Takuji Takana
Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination.
Biochemical pharmacology 2003;66(7):1253-61.
2003: Yu Nakagawa; Kazuhiro Irie; Nobuhiro Yamanaka; Hajime Ohigashi; Ken-ichiro Tsuda
Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes.
Bioorganic & medicinal chemistry letters 2003;13(18):3015-9.
2003: Akira Murakami; Kazuhiko Matsumoto; Koichi Koshimizu; Hajime Ohigashi
Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages.
Cancer letters 2003;195(1):17-25.
2003: Akira Murakami; Daisuke Takahashi; Kazuma Hagihara; Koichi Koshimizu; Hajime Ohigashi
Combinatorial effects of nonsteroidal anti-inflammatory drugs and food constituents on production of prostaglandin E2 and tumor necrosis factor-alpha in RAW264.7 murine macrophages.
Bioscience, biotechnology, and biochemistry 2003;67(5):1056-62.
2003: Akira Murakami; Daisuke Takahashi; Koichi Koshimizu; Hajime Ohigashi
Synergistic suppression of superoxide and nitric oxide generation from inflammatory cells by combined food factors.
Mutation research 2003;523-524():151-61.
2003: Ha Won Kim; Akira Murakami; Marshall V Williams; Hajime Ohigashi
Mutagenicity of reactive oxygen and nitrogen species as detected by co-culture of activated inflammatory leukocytes and AS52 cells.
Carcinogenesis 2003;24(2):235-41.
2002: Yumi Shimoji; Yoshitaka Tamura; Yoshimasa Nakamura; Kumiko Nanda; Shoko Nishidai; Yasushi Nishikawa; Nobuhiro Ishihara; Kazuo Uenakai; Hajime Ohigashi
Isolation and identification of DPPH radical scavenging compounds in Kurosu (Japanese unpolished rice vinegar).
Journal of agricultural and food chemistry 2002;50(22):6501-3.
2002: Qiao Zheng; Yoshinobu Hirose; Naoki Yoshimi; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Keiko Sakata; Yuji Matsumoto; Yoshikatsu Sayama; Hideki Mori
Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells.
Journal of cancer research and clinical oncology 2002;128(10):539-46.
2002: Suratwadee Jiwajinda; Vilai Santisopasri; Akira Murakami; Hiromu Sugiyama; Monique Gasquet; Elias Riad; Guy Balansard; Hajime Ohigashi
In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.
Journal of ethnopharmacology 2002;82(1):55-8.
2002: Akira Morimoto; Kazuhiro Irie; Kazuma Murakami; Hajime Ohigashi; Mayumi Shindo; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa
Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23.
Biochemical and biophysical research communications 2002;295(2):306-11.
2002: Akiko Masuda; Kazuhiro Irie; Yu Nakagawa; Hajime Ohigashi
Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes.
Bioscience, biotechnology, and biochemistry 2002;66(7):1615-7.
2002: Akira Murakami; Yoshimasa Nakamura; Koichi Koshimizu; Daisuke Takahashi; Kazuhiro Matsumoto; Kazuma Hagihara; Hisaji Taniguchi; Eisaku Nomura; Asao Hosoda; Takuo Tsuno; Yuko Maruta; Ha Won Kim; Kyuichi Kawabata; Hajime Ohigashi
FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: comparison with ferulic acid.
Cancer letters 2002;180(2):121-9.
2002: Asao Hosoda; Eisaku Nomura; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Kazuhiko Mizuno; Hisaji Taniguchi
Synthesis of feruloyl-myo-insitol derivatives and their inhibitory effects on phorbol ester-induced superoxide generation and Esptein-Barr virus activation.
Bioorganic & medicinal chemistry 2002;10(6):1855-63.
2002: Kazuma Murakami; Kazuhiro Irie; Akira Morimoto; Hajime Ohigashi; Mayumi Shindo; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa
Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.
Biochemical and biophysical research communications 2002;294(1):5-10.
2002: Akira Murakami; Daisuke Takahashi; Takashi Kinoshita; Koichi Koshimizu; Ha Won Kim; Akira Yoshihiro; Yoshimasa Nakamura; Suratwadee Jiwajinda; Junji Terao; Hajime Ohigashi
Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.
Carcinogenesis 2002;23(5):795-802.
2002: Eisaku Nomura; Asao Hosoda; Hideko Morishita; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Hisaji Taniguchi
Synthesis of novel polyphenols consisted of ferulic and gallic acids, and their inhibitory effects on phorbol ester-induced Epstein-Barr virus activation and superoxide generation.
Bioorganic & medicinal chemistry 2002;10(4):1069-75.
2002: Ha Won Kim; Akira Murakami; Yoshimasa Nakamura; Hajime Ohigashi
Screening of edible Japanese plants for suppressive effects on phorbol ester-induced superoxide generation in differentiated HL-60 cells and AS52 cells.
Cancer letters 2002;176(1):7-16.
2002: Kazuhiro Irie; Akifumi Nakahara; Yu Nakagawa; Hajime Ohigashi; Mayumi Shindo; Hiroyuki Fukuda; Hiroaki Konishi; Ushio Kikkawa; Kaori Kashiwagi; Naoaki Saito
Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity.
Pharmacology & therapeutics 2002;93(2-3):271-81.
2002: Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Shigeru Kuwahara; Wataru Kuki; Yasuo Takahashi; Keisuke Hosotani; Satsuki Kawahara; Yumi Matsuoka
Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin.
BioFactors (Oxford, England) 2002;16(3-4):73-82.
2001: Suratwadee Jiwajinda; Vilai Santisopasri; Akira Murakami; N Hirai; Hajime Ohigashi
Quassinoids from Eurycoma longifolia as plant growth inhibitors.
Phytochemistry 2001;58(6):959-62.
2001: Mayumi Shindo; Kazuhiro Irie; Akifumi Nakahara; Hajime Ohigashi; Hiroaki Konishi; Ushio Kikkawa; Hiroyuki Fukuda; PA Wender
Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding.
Bioorganic & medicinal chemistry 2001;9(8):2073-81.
2001: Yoshimasa Nakamura; K Torikai; Hajime Ohigashi
A catechol antioxidant protocatechuic acid potentiates inflammatory leukocyte-derived oxidative stress in mouse skin via a tyrosinase bioactivation pathway.
Free radical biology & medicine 2001;30(9):967-78.
2001: Suratwadee Jiwajinda; N Hirai; K Watanabe; Vilai Santisopasri; N Chuengsamarnyart; Koichi Koshimizu; Hajime Ohigashi
Occurrence of the insecticidal 16,17-didehydro-16(E)-stemofoline in Stemona collinsae.
Phytochemistry 2001;56(7):693-5.
2001: Yoshiaki Nakagawa; Kazuhiro Irie; Yoshimasa Nakamura; Hajime Ohigashi
The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities.
Bioorganic & medicinal chemistry letters 2001;11(5):723-8.
2001: M Tanaka; Kazuhiro Irie; Yoshiaki Nakagawa; Yoshimasa Nakamura; Hajime Ohigashi; PA Wender
The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding.
Bioorganic & medicinal chemistry letters 2001;11(5):719-22.
2001: E H Lahlou; Nobuhiro Hirai; T Kamo; M Tsuda; Hajime Ohigashi
Actinidic acid, a new triterpene phytoalexin from unripe kiwi fruit.
Bioscience, biotechnology, and biochemistry 2001;65(2):480-3.
2000: Akira Murakami; K Kawabata; T Koshiba; G Gao; Yoshimasa Nakamura; Koichi Koshimizu; Hajime Ohigashi
Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha.
Cancer research 2000;60(22):6326-31.
2000: OK Kim; Akira Murakami; Daisuke Takahashi; Yoshimasa Nakamura; K Torikai; Ha Won Kim; Hajime Ohigashi
An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin.
Bioscience, biotechnology, and biochemistry 2000;64(11):2504-7.
2000: Kazuhiro Irie; Akifumi Nakahara; Y Ikawa; M Tanaka; Yoshiaki Nakagawa; Yoshimasa Nakamura; Hajime Ohigashi; PA Wender
Synthesis and tumor-promoting activities of 12-Epi-phorbol-12,13-dibutyrate.
Bioscience, biotechnology, and biochemistry 2000;64(11):2429-36.
2000: T Kamo; Nobuhiro Hirai; M Tsuda; D Fujioka; Hajime Ohigashi
Changes in the content and biosynthesis of phytoalexins in banana fruit.
Bioscience, biotechnology, and biochemistry 2000;64(10):2089-98.
2000: Yoshimasa Nakamura; K Torikai; Y Ohto; Akira Murakami; Tomoyuki Tanaka; Hajime Ohigashi
A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: dose-and timing-dependent enhancement and involvement of bioactivation by tyrosinase.
Carcinogenesis 2000;21(10):1899-907.
2000: Akira Murakami; Yoshimasa Nakamura; T Tanaka; K Kawabata; Daisuke Takahashi; Koichi Koshimizu; Hajime Ohigashi
Suppression by citrus auraptene of phorbol ester-and endotoxin-induced inflammatory responses: role of attenuation of leukocyte activation.
Carcinogenesis 2000;21(10):1843-50.
2000: Yoshiaki Nakagawa; Kazuhiro Irie; Hajime Ohigashi; Hideo Hayashi; PA Wender
Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V.
Bioorganic & medicinal chemistry letters 2000;10(18):2087-90.
2000: Akira Murakami; Yoshimasa Nakamura; K Torikai; T Tanaka; T Koshiba; Koichi Koshimizu; S Kuwahara; Yoshito Takahashi; K Ogawa; M Yano; H Tokuda; H Nishino; Y Mimaki; Y Sashida; S Kitanaka; Hajime Ohigashi
Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice.
Cancer research 2000;60(18):5059-66.
2000: Nobuhiro Hirai; S Sakashita; T Sano; T Inoue; Hajime Ohigashi; C Premasthira; Y Asakawa; J Harada; Y Fujii
Allelochemicals of the tropical weed Sphenoclea zeylanica.
Phytochemistry 2000;55(2):131-40.
2000: Yoshimasa Nakamura; Yasujiro Morimitsu; T Uzu; Hajime Ohigashi; Akira Murakami; Y Naito; Y Nakagawa; Toshihiko Osawa; K Uchida
A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates.
Cancer letters 2000;157(2):193-200.
2000: Akira Murakami; Megumi Kadota; Daisuke Takahashi; Hisaji Taniguchi; Eisaku Nomura; Asao Hosoda; Takuo Tsuno; Yuko Maruta; Hajime Ohigashi; Koichi Koshimizu
Suppressive effects of novel ferulic acid derivatives on cellular responses induced by phorbol ester, and by combined lipopolysaccharide and interferon-gamma.
Cancer letters 2000;157(1):77-85.
2000: Nobuhiro Hirai; M Sugie; Masaru Wada; E H Lahlou; T Kamo; Ryuji Yoshida; M Tsuda; Hajime Ohigashi
Triterpene phytoalexins from strawberry fruit.
Bioscience, biotechnology, and biochemistry 2000;64(8):1707-12.
2000: Asao Hosoda; Eisaku Nomura; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Kazuhiko Mizuno; Hisaji Taniguchi
Synthesis of feruloyl-myo-inositols and their inhibitory effects on superoxide generation.
Bioorganic & medicinal chemistry letters 2000;10(13):1439-42.
2000: Nobuhiro Hirai; Ryuji Yoshida; Y Todoroki; Hajime Ohigashi
Biosynthesis of abscisic acid by the non-mevalonate pathway in plants, and by the mevalonate pathway in fungi.
Bioscience, biotechnology, and biochemistry 2000;64(7):1448-58.
2000: OK Kim; Akira Murakami; Yoshimasa Nakamura; N Takeda; H Yoshizumi; Hajime Ohigashi
Novel nitric oxide and superoxide generation inhibitors, persenone A and B, from avocado fruit.
Journal of agricultural and food chemistry 2000;48(5):1557-63.
2000: Akira Murakami; K Toyota; S Ohura; Koichi Koshimizu; Hajime Ohigashi
Structure-activity relationships of (1'S)-1'-acetoxychavicol acetate, a major constituent of a southeast Asian condiment plant Languas galanga, on the inhibition of tumor-promoter-induced Epstein-Barr virus activation.
Journal of agricultural and food chemistry 2000;48(5):1518-23.
2000: Kunihiro Kawabata; Takuji Tanaka; T Yamamoto; Akira Hara; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; G D Stoner; Hideki Mori
Suppression of N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis by dietary feeding of auraptene.
Journal of experimental & clinical cancer research : CR 2000;19(1):45-52.
2000: Akira Murakami; M Nakashima; T Koshiba; T Maoka; H Nishino; M Yano; T Sumida; O K Kim; Koichi Koshimizu; Hajime Ohigashi
Modifying effects of carotenoids on superoxide and nitric oxide generation from stimulated leukocytes.
Cancer letters 2000;149(1-2):115-23.
2000: Kunihiro Kawabata; Takuji Tanaka; T Yamamoto; Jun Ushida; Akira Hara; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; G D Stoner; Hideki Mori
Suppression of N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis by dietary feeding of 1'-acetoxychavicol acetate.
Japanese journal of cancer research : Gann 2000;91(2):148-55.
2000: Suratwadee Jiwajinda; Vilai Santisopasri; Hajime Ohigashi
Coumarin-related compounds as plant growth inhibitors from two rutaceous plants in Thailand.
Bioscience, biotechnology, and biochemistry 2000;64(2):420-3.
2000: Yoshimasa Nakamura; Hajime Ohigashi; S Masuda; Akira Murakami; Yasujiro Morimitsu; Y Kawamoto; Toshihiko Osawa; M Imagawa; K Uchida
Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates.
Cancer research 2000;60(2):219-25.
2000: Akira Murakami; G Gao; M Omura; M Yano; C Ito; H Furukawa; Daisuke Takahashi; Koichi Koshimizu; Hajime Ohigashi
1,1-Dimethylallylcoumarins potently suppress both lipopolysaccharide- and interferon-gamma-induced nitric oxide generation in mouse macrophage RAW 264.7 cells.
Bioorganic & medicinal chemistry letters 2000;10(1):59-62.
2000: Akira Murakami; Yoshimasa Nakamura; Y Ohto; M Yano; T Koshiba; Koichi Koshimizu; H Tokuda; H Nishino; Hajime Ohigashi
Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid.
BioFactors (Oxford, England) 2000;12(1-4):187-92.
2000: Akira Murakami; K Wada; N Ueda; K Sasaki; M Haga; Wataru Kuki; Yoshito Takahashi; H Yonei; Koichi Koshimizu; Hajime Ohigashi
In vitro absorption and metabolism of a citrus chemopreventive agent, auraptene, and its modifying effects on xenobiotic enzyme activities in mouse livers.
Nutrition and cancer 2000;36(2):191-9.
2000: Akira Murakami; A M Ali; K Mat-Salleh; Koichi Koshimizu; Hajime Ohigashi
Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia.
Bioscience, biotechnology, and biochemistry 2000;64(1):9-16.
1999: Akira Murakami; M Takahashi; Suratwadee Jiwajinda; Koichi Koshimizu; Hajime Ohigashi
Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation.
Bioscience, biotechnology, and biochemistry 1999;63(10):1811-2.
1999: Kazuhiro Irie; Akifumi Nakahara; Hajime Ohigashi; Hiroyuki Fukuda; PA Wender; Hiroaki Konishi; Ushio Kikkawa
Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D.
Bioorganic & medicinal chemistry letters 1999;9(17):2487-90.
1999: Takuji Tanaka; H Sugiura; R Inaba; A Nishikawa; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi
Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice.
Carcinogenesis 1999;20(8):1471-6.
1999: Yoshimasa Nakamura; N Kawamoto; Y Ohto; K Torikai; Akira Murakami; Hajime Ohigashi
A diacetylenic spiroketal enol ether epoxide, AL-1, from Artemisia lactiflora inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion possibly by suppression of oxidative stress.
Cancer letters 1999;140(1-2):37-45.
1999: Akira Murakami; G Gao; O K Kim; M Omura; M Yano; C Ito; H Furukawa; Suratwadee Jiwajinda; Koichi Koshimizu; Hajime Ohigashi
Identification of coumarins from the fruit of Citrus hystrix DC as inhibitors of nitric oxide generation in mouse macrophage RAW 264.7 cells.
Journal of agricultural and food chemistry 1999;47(1):333-9.
1998: Yoshimasa Nakamura; Akira Murakami; Y Ohto; K Torikai; Tomoyuki Tanaka; Hajime Ohigashi
Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1'-acetoxychavicol acetate.
Cancer research 1998;58(21):4832-9.
1998: Yoshiaki Nakagawa; Kazuhiro Irie; Yoshimasa Nakamura; Hajime Ohigashi; Hideo Hayashi
Synthesis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V.
Bioscience, biotechnology, and biochemistry 1998;62(8):1568-73.
1998: Takuji Tanaka; Kunihiro Kawabata; M Kakumoto; Akira Hara; Akira Murakami; Wataru Kuki; Yoshito Takahashi; H Yonei; M Maeda; T Ota; S Odashima; T Yamane; Koichi Koshimizu; Hajime Ohigashi
Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes.
Cancer research 1998;58(12):2550-6.
1998: Akira Murakami; Y Kitazono; Suratwadee Jiwajinda; Koichi Koshimizu; Hajime Ohigashi
Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein-Barr virus activation.
Planta medica 1998;64(4):319-23.
1998: Yoshimasa Nakamura; Y Ohto; Akira Murakami; Toshihiko Osawa; Hajime Ohigashi
Inhibitory effects of curcumin and tetrahydrocurcuminoids on the tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo.
Japanese journal of cancer research : Gann 1998;89(4):361-70.
1998: OK Kim; Akira Murakami; Yoshimasa Nakamura; Hajime Ohigashi
Screening of edible Japanese plants for nitric oxide generation inhibitory activities in RAW 264.7 cells.
Cancer letters 1998;125(1-2):199-207.
1998: Takuji Tanaka; Kunihiro Kawabata; M Kakumoto; K Matsunaga; Hideki Mori; Akira Murakami; Wataru Kuki; Yoshito Takahashi; H Yonei; K Satoh; Akira Hara; M Maeda; T Ota; S Odashima; Koichi Koshimizu; Hajime Ohigashi
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats.
Carcinogenesis 1998;19(3):425-31.
1998: Akira Murakami; H Morita; R Safitri; A Ramlan; Koichi Koshimizu; Hajime Ohigashi
Screening for in vitro anti-tumor-promoting activities of edible plants from Indonesia.
Cancer detection and prevention 1998;22(6):516-25.
1997: Takuji Tanaka; Kunihiro Kawabata; M Kakumoto; Hiroki Makita; Akira Hara; Hideki Mori; K Satoh; A Hara; Akira Murakami; Wataru Kuki; Yoshito Takahashi; H Yonei; Koichi Koshimizu; Hajime Ohigashi
Citrus auraptene inhibits chemically induced colonic aberrant crypt foci in male F344 rats.
Carcinogenesis 1997;18(11):2155-61.
1997: Takuji Tanaka; Kunihiro Kawabata; M Kakumoto; Hiroki Makita; K Matsunaga; Hideki Mori; K Satoh; Akira Hara; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate.
Japanese journal of cancer research : Gann 1997;88(9):821-30.
1997: Kazuhiro Irie; Y Yanai; K Oie; J Ishizawa; Yoshiaki Nakagawa; Hajime Ohigashi; PA Wender; Ushio Kikkawa
Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase C gamma.
Bioorganic & medicinal chemistry 1997;5(8):1725-37.
1997: Yoshiaki Nakagawa; Kazuhiro Irie; Yoshimasa Nakamura; Hajime Ohigashi; Hideo Hayashi
Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V.
Bioscience, biotechnology, and biochemistry 1997;61(8):1415-7.
1997: Akira Murakami; Wataru Kuki; Yoshito Takahashi; H Yonei; Yoshimasa Nakamura; Y Ohto; Hajime Ohigashi; Koichi Koshimizu
Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin, possibly through suppression of superoxide generation in leukocytes.
Japanese journal of cancer research : Gann 1997;88(5):443-52.
1997: Takuji Tanaka; Hiroki Makita; Toshihiko Kawamori; Kunihiro Kawabata; Hideki Mori; Akira Murakami; K Satoh; Akira Hara; Hajime Ohigashi; Koichi Koshimizu
A xanthine oxidase inhibitor 1'-acetoxychavicol acetate inhibits azoxymethane-induced colonic aberrant crypt foci in rats.
Carcinogenesis 1997;18(5):1113-8.
1996: Yoshimasa Nakamura; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi
Inhibitory effect of pheophorbide a, a chlorophyll-related compound, on skin tumor promotion in ICR mouse.
Cancer letters 1996;108(2):247-55.
1996: Hajime Ohigashi; Akira Murakami; Koichi Koshimizu
An approach to functional food: cancer preventive potential of vegetables and fruits and their active constituents.
Nutrition reviews 1996;54(11 Pt 2):S24-8.
1996: Akira Murakami; S Ohura; Y Nakamura; Koichi Koshimizu; Hajime Ohigashi
1'-Acetoxychavicol acetate, a superoxide anion generation inhibitor, potently inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in ICR mouse skin.
Oncology 1996;53(5):386-91.
1996: Kazuhiro Irie; Yoshimasa Nakamura; Hajime Ohigashi; H Tokuyama; S Yamago; E Nakamura
Photocytotoxicity of water-soluble fullerene derivatives.
Bioscience, biotechnology, and biochemistry 1996;60(8):1359-61.
1996: Yoshimasa Nakamura; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi
Identification of pheophorbide a and its related compounds as possible anti-tumor promoters in the leaves of Neptunia oleracea.
Bioscience, biotechnology, and biochemistry 1996;60(6):1028-30.
1996: M Ohnishi; Takuji Tanaka; Hiroki Makita; Toshihiko Kawamori; Hideki Mori; K Satoh; Akira Hara; Akira Murakami; Hajime Ohigashi; Koichi Koshimizu
Chemopreventive effect of a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate, on rat oral carcinogenesis.
Japanese journal of cancer research : Gann 1996;87(4):349-56.
1995: Akira Murakami; Suratwadee Jiwajinda; Koichi Koshimizu; Hajime Ohigashi
Screening for in vitro anti-tumor promoting activities of edible plants from Thailand.
Cancer letters 1995;95(1-2):139-46.
1994: Koichi Koshimizu; Hajime Ohigashi; M A Huffman
Use of Vernonia amygdalina by wild chimpanzee: possible roles of its bitter and related constituents.
Physiology & behavior 1994;56(6):1209-16.
1993: M Jisaka; Hajime Ohigashi; K Takegawa; M A Huffman; Koichi Koshimizu
Antitumoral and antimicrobial activities of bitter sesquiterpene lactones of Vernonia amygdalina, a possible medicinal plant used by wild chimpanzees.
Bioscience, biotechnology, and biochemistry 1993;57(5):833-4.
1992: Hajime Ohigashi; Yasuyoshi Sakai; K Yamaguchi; I Umezaki; Koichi Koshimizu
Possible anti-tumor promoting properties of marine algae and in vivo activity of Wakame seaweed extract.
Bioscience, biotechnology, and biochemistry 1992;56(6):994-5.
1992: Akira Murakami; S Tanaka; Hajime Ohigashi; M Hirota; R Irie; N Takeda; A Tatematsu; Koichi Koshimizu
Chalcone tetramers, lophirachalcone and alatachalcone, from Lophira alata as possible anti-tumor promoters.
Bioscience, biotechnology, and biochemistry 1992;56(5):769-72.
1992: M Jisaka; M Kawanaka; H Sugiyama; K Takegawa; M A Huffman; Hajime Ohigashi; Koichi Koshimizu
Antischistosomal activities of sesquiterpene lactones and steroid glucosides from Vernonia amygdalina, possibly used by wild chimpanzees against parasite-related diseases.
Bioscience, biotechnology, and biochemistry 1992;56(5):845-6.
1991: Akira Murakami; Hajime Ohigashi; M Jisaka; M Hirota; R Irie; Koichi Koshimizu
Inhibitory effects of new types of biflavonoid-related polyphenols; lophirone A and lophiraic acid, on some tumor promoter-induced biological responses in vitro and in vivo.
Cancer letters 1991;58(1-2):101-6.
1991: H Hirotani; Hajime Ohigashi; M Kobayashi; Koichi Koshimizu; E Takahashi
Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols.
FEMS microbiology letters 1991;61(1):13-7.
1988: Koichi Koshimizu; Hajime Ohigashi; H Tokuda; A Kondo; K Yamaguchi
Screening of edible plants against possible anti-tumor promoting activity.
Cancer letters 1988;39(3):247-57.