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Yasushi Ohizumi

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Jing Xu; Tohru Yamakuni; Bo Yang; Lingzhi Fang; Yuanqiang Guo; Shaonan Wang; Yasushi Ohizumi
Four new myrsinol diterpenes from Euphorbia prolifera.
Kiyomitsu Nemoto; Yasushi Ohizumi; Akihito Yokosuka; Chiaki Yoshida; Hironori Fujiwara; Ayaka Ikeda; Junko Kimura; Yoshihiro Mimaki; Junki Mori; Masakuni Degawa
Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines.
Jing Xu; Tohru Yamakuni; Peng Zhao; Ping Guo; Yuanqiang Guo; Da-qing Jin; Yasushi Ohizumi
Three new iridoids from the roots of Valeriana jatamansi.

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2013: Jing Xu; Tohru Yamakuni; Bo Yang; Lingzhi Fang; Yuanqiang Guo; Shaonan Wang; Yasushi Ohizumi
Four new myrsinol diterpenes from Euphorbia prolifera.
Journal of natural medicines 2013;67(2):333-8.
2013: Kiyomitsu Nemoto; Yasushi Ohizumi; Akihito Yokosuka; Chiaki Yoshida; Hironori Fujiwara; Ayaka Ikeda; Junko Kimura; Yoshihiro Mimaki; Junki Mori; Masakuni Degawa
Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines.
Biochemical and biophysical research communications 2013;431(3):530-4.
2012: Jing Xu; Tohru Yamakuni; Peng Zhao; Ping Guo; Yuanqiang Guo; Da-qing Jin; Yasushi Ohizumi
Three new iridoids from the roots of Valeriana jatamansi.
Journal of natural medicines 2012;66(4):653-7.
2012: Jing Xu; Tohru Yamakuni; Chunfeng Xie; Yuanqiang Guo; Da-qing Jin; Yonggang Ma; Yasushi Ohizumi
New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production.
Bioorganic & medicinal chemistry letters 2012;22(11):3612-8.
2012: Jing Xu; Tohru Yamakuni; Ping Guo; Yuanqiang Guo; Yushan Li; Yasushi Ohizumi
Isolation, structural elucidation, and neuroprotective effects of iridoids from Valeriana jatamansi.
Bioscience, biotechnology, and biochemistry 2012;76(7):1401-3.
2011: Daisuke Saigusa; Masatoshi Shibuya; Yoshihisa Tomioka; Hiroyuki Yamakoshi; Yoshiharu Iwabuchi; Daisuke Jinno; Yoshihiro Mimaki; Akira Naganuma; Yasushi Ohizumi; Akihito Yokosuka; Tohru Yamakuni
High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound.
Analytical and bioanalytical chemistry 2011;400(10):3635-41.
2011: Hironori Fujiwara; Nobuyuki Hitomi; Ako Kogure; Yoshihiro Mimaki; Kiyoshi Murata; Masahiro Sakamoto; Kikuji Yamaguchi; Tohru Yamakuni; Yasushi Ohizumi
Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells.
Journal of pharmacological sciences 2011;116(4):384-7.
2011: Jing Xu; Tohru Yamakuni; Zhanping Sun; Liping Gui; Ping Guo; Yuanqiang Guo; Cuizhou Liu; Yasushi Ohizumi
Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis.
Bioscience, biotechnology, and biochemistry 2011;75(7):1386-8.
2010: Tohru Yamakuni; Akira Nakajima; Yasushi Ohizumi
[Preventive action of nobiletin, a constituent of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, against amyloid-beta peptide-induced neurotoxicity expression and memory impairment].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(4):517-20.
2009: Yui Yamamoto; Norifumi Shioda; Feng Han; Shigeki Moriguchi; Akira Nakajima; Akihito Yokosuka; Yoshihiro Mimaki; Yutaka Sashida; Tohru Yamakuni; Yasushi Ohizumi; Kohji Fukunaga
Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.
Brain research 2009;1295():218-29.
2009: Md Al Rahim; Akira Nakajima; Daisuke Saigusa; Naomi Tetsu; Yuji Maruyama; Masatoshi Shibuya; Hiroyuki Yamakoshi; Yoshihisa Tomioka; Yoshiharu Iwabuchi; Yasushi Ohizumi; Tohru Yamakuni
4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.
Biochemistry 2009;48(32):7713-21.
2008: Md Al Rahim; Akira Nakajima; Norihiko Misawa; Kazutoshi Shindo; Kyoko Adachi; Yoshikazu Shizuri; Yasushi Ohizumi; Tohru Yamakuni
A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Abeta-inhibition of the cascade in cultured rat CNS neurons.
European journal of pharmacology 2008;600(1-3):10-7.
2008: Tohru Yamakuni; Akira Nakajima; Yasushi Ohizumi
Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, and its application for development of functional foods.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2008;132(3):155-9.
2008: Hiroshi Onozuka; Akira Nakajima; Kentaro Matsuzaki; Ryong-Woon Shin; Koichi Ogino; Daisuke Saigusa; Naomi Tetsu; Akihito Yokosuka; Yutaka Sashida; Yoshihiro Mimaki; Tohru Yamakuni; Yasushi Ohizumi
Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease.
The Journal of pharmacology and experimental therapeutics 2008;326(3):739-44.
2008: Kentaro Matsuzaki; Kenichi Miyazaki; Seiichiro Sakai; Hiromu Yawo; Norihito Nakata; Shigeki Moriguchi; Kohji Fukunaga; Akihito Yokosuka; Yutaka Sashida; Yoshihiro Mimaki; Tohru Yamakuni; Yasushi Ohizumi
Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.
European journal of pharmacology 2008;578(2-3):194-200.
2007: Masashi Kitazawa; Yasushi Ohizumi; Yuichi Oike; Takanori Hishinuma; Seiichi Hashimoto
Angiopoietin-related growth factor suppresses gluconeogenesis through the Akt/forkhead box class O1-dependent pathway in hepatocytes.
The Journal of pharmacology and experimental therapeutics 2007;323(3):787-93.
2007: Yuanqiang Guo; Yushan Li; Jing Xu; Ning Li; Tohru Yamakuni; Yasushi Ohizumi
Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana.
Chemical & pharmaceutical bulletin 2007;55(10):1532-4.
2007: Akira Nakajima; Tohru Yamakuni; Mitsuya Haraguchi; Naoki Omae; Si-Young Song; Chieko Kato; Osamu Nakagawasai; Takeshi Tadano; Akihito Yokosuka; Yoshihiro Mimaki; Yutaka Sashida; Yasushi Ohizumi
Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.
Journal of pharmacological sciences 2007;105(1):122-6.
2007: Akira Nakajima; Tohru Yamakuni; Kentaro Matsuzaki; Norihito Nakata; Hiroshi Onozuka; Akihito Yokosuka; Yutaka Sashida; Yoshihiro Mimaki; Yasushi Ohizumi
Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by activation of extracellular signal-regulated kinase signaling.
The Journal of pharmacology and experimental therapeutics 2007;321(2):784-90.
2006: Hidekazu Kiyoshi; Daiju Yamazaki; Susumu Ohya; Mika Kitsukawa; Katsuhiko Muraki; Shin-ya Saito; Yasushi Ohizumi; Yuji Imaizumi
Molecular and electrophysiological characteristics of K+ conductance sensitive to acidic pH in aortic smooth muscle cells of WKY and SHR.
American journal of physiology. Heart and circulatory physiology 2006;291(6):H2723-34.
2006: Hironori Fujiwara; Koh Iwasaki; Katsutoshi Furukawa; Takashi Seki; Mei He; Masahiro Maruyama; Naoki Tomita; Yukitsuka Kudo; Makoto Higuchi; Takaomi C Saido; Sumihiro Maeda; Akihiko Takashima; Masahiko Hara; Yasushi Ohizumi; Hiroyuki Arai
Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins.
Journal of neuroscience research 2006;84(2):427-33.
2006: Takayuki Koizumi; Mayumi Abe; Tohru Yamakuni; Yasushi Ohizumi; Yukio Hitotsuyanagi; Koichi Takeya; Yasufumi Sato
Metronomic scheduling of a cyclic hexapeptide Ra-VII for anti-angiogenesis, tumor vessel maturation and anti-tumor activity.
Cancer science 2006;97(7):665-74.
2006: Masaki Saito; Megumi Hori; Yutaro Obara; Yasushi Ohizumi; Satoko Ohkubo; Norimichi Nakahata
Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;28(4):263-71.
2006: Yuka Ono; Eri Hattori; Yukitaka Fukaya; Shoji Imai; Yasushi Ohizumi
Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats.
Journal of ethnopharmacology 2006;106(2):238-44.
2006: Kentaro Matsuzaki; Tohru Yamakuni; Michio Hashimoto; Abdul Md Haque; Osamu Shido; Yoshihiro Mimaki; Yutaka Sashida; Yasushi Ohizumi
Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats.
Neuroscience letters 2006;400(3):230-4.
2006: Masashi Kitazawa; Yasutaka Shibata; Seiichi Hashimoto; Yasushi Ohizumi; Tohru Yamakuni
Proinsulin C-peptide stimulates a PKC/IkappaB/NF-kappaB signaling pathway to activate COX-2 gene transcription in Swiss 3T3 fibroblasts.
Journal of biochemistry 2006;139(6):1083-8.
2006: Yasufumi Toriniwa; Xiaochuan Lv; Yasuo Kodama; Yasushi Ohizumi; Makoto Yoshida; Norimichi Nakahata
Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis.
The Journal of pharmacy and pharmacology 2006;58(6):859-66.
2006: Atsushi Kakizaki; Masami Takahashi; Hiroyuki Akagi; Eiichi Tachikawa; Toshifumi Yamamoto; Eiichi Taira; Tohru Yamakuni; Yasushi Ohizumi
Ca2+ channel activating action of maitotoxin in cultured brainstem neurons.
European journal of pharmacology 2006;536(3):223-31.
2006: Yuanqiang Guo; Jing Xu; Yushan Li; Tohru Yamakuni; Yasushi Ohizumi
Three-membered ring sesquiterpenoids with NGF-potentiating activity from the roots of Valeriana fauriei.
Planta medica 2006;72(4):373-5.
2006: Tohru Yamakuni; Koichi Aoki; Keigo Nakatani; Nobuhiko Kondo; Hisae Oku; Kyoko Ishiguro; Yasushi Ohizumi
Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells.
Neuroscience letters 2006;394(3):206-10.
2006: Yuanqiang Guo; Yushan Li; Jing Xu; Ryuichi Watanabe; Yasukatsu Oshima; Tohru Yamakuni; Yasushi Ohizumi
Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana.
Journal of natural products 2006;69(2):274-6.
2006: Yuanqiang Guo; Jing Xu; Yushan Li; Ryuichi Watanabe; Yasukatsu Oshima; Tohru Yamakuni; Yasushi Ohizumi
Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei.
Chemical & pharmaceutical bulletin 2006;54(1):123-5.
2005: Hiroyuki Nagase; Naoki Omae; Akiko Omori; Osamu Nakagawasai; Takeshi Tadano; Akihito Yokosuka; Yutaka Sashida; Yoshihiro Mimaki; Tohru Yamakuni; Yasushi Ohizumi
Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities.
Biochemical and biophysical research communications 2005;337(4):1330-6.
2005: Dileep Kumar Rohra; Shin-ya Saito; Yasushi Ohizumi
Low extracellular Cl- environment attenuates changes in intracellular pH and contraction following extracellular acidosis in Wistar Kyoto rat aorta.
Pharmacology 2005;75(1):30-6.
2005: Hiroyuki Nagase; Tohru Yamakuni; Kentaro Matsuzaki; Yuji Maruyama; Jiro Kasahara; Yoshimi Hinohara; Shunzo Kondo; Yoshihiro Mimaki; Yutaka Sashida; A William Tank; Kohji Fukunaga; Yasushi Ohizumi
Mechanism of neurotrophic action of nobiletin in PC12D cells.
Biochemistry 2005;44(42):13683-91.
2005: Ken-Ichi Onodera; Hideshi Nakamura; Yuichi Oba; Yasushi Ohizumi; Makoto Ojika
Zooxanthellamide Cs: vasoconstrictive polyhydroxylated macrolides with the largest lactone ring size from a marine dinoflagellate of Symbiodinium sp.
Journal of the American Chemical Society 2005;127(29):10406-11.
2005: Kohichi Aoki; Tohru Yamakuni; Masaaki Yoshida; Yasushi Ohizumi
Ephedorae herba decreases lipopolysaccharide-induced cyclooxgenase-2 protein expression and NF-kappaB-dependent transcription in C6 rat glioma cells.
Journal of pharmacological sciences 2005;98(3):327-30.
2005: Masashi Kitazawa; Tohru Yamakuni; Si-Young Song; Chieko Kato; Reiko Tsuchiya; Mami Ishida; Nobuhide Suzuki; Eijiro Adachi; Shintaro Iwashita; Susumu Ueno; Nobuyuki Yanagihara; Masato Taoka; Toshiaki Isobe; Yasushi Ohizumi
Intracellular cAMP controls a physical association of V-1 with CapZ in cultured mammalian endocrine cells.
Biochemical and biophysical research communications 2005;331(1):181-6.
2005: Masashi Tsuda; Masaaki Yamakawa; Seiko Oka; Yasushi Tanaka; Yasutake Hoshino; Yuzuru Mikami; Ayumi Sato; Hironori Fujiwara; Yasushi Ohizumi; Jun'ichi Kobayashi
Brasilibactin A, a cytotoxic compound from actinomycete Nocardia brasiliensis.
Journal of natural products 2005;68(3):462-4.
2005: Yasushi Horai; Ken-Ichi Furukawa; Shingo Iwata; Yasushi Ohizumi
Changes in pH increase perfusion pressure of coronary arteries in the rat.
Journal of pharmacological sciences 2005;97(3):400-7.
2004: Dileep Kumar Rohra; Tohru Yamakuni; Yasushi Ohizumi
Acidosis-induced protein tyrosine phosphorylation depends on Ca2+ influx via voltage-dependent Ca2+ channels in SHR aorta.
European journal of pharmacology 2004;504(1-2):105-11.
2004: Keigo Nakatani; Tohru Yamakuni; Nobuhiko Kondo; Tsutomu Arakawa; Kenji Oosawa; Susumu Shimura; Hiroyasu Inoue; Yasushi Ohizumi
gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.
Molecular pharmacology 2004;66(3):667-74.
2004: Hironori Fujiwara; Tohru Yamakuni; Mitsuhiro Ueno; Masaaki Ishizuka; Takashi Shinkawa; Toshiaki Isobe; Yasushi Ohizumi
IC101 induces apoptosis by Akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with Akt in L1210 cells.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1288-95.
2004: Shin-Ya Saito; Masashi Tanaka; Kimihiro Matsunaga; Yushan Li; Yasushi Ohizumi
The combination of rat mast cell and rabbit aortic smooth muscle is the simple bioassay for the screening of anti-allergic ingredient from methanolic extract of Corydalis tuber.
Biological & pharmaceutical bulletin 2004;27(8):1270-4.
2004: Shin-ya Saito; Jue Feng; Atsushi Kira; Jun'ichi Kobayashi; Yasushi Ohizumi
Amphidinolide H, a novel type of actin-stabilizing agent isolated from dinoflagellate.
Biochemical and biophysical research communications 2004;320(3):961-5.
2004: Shin-ya Saito; Sachie Kamiyama; Mayumi Oda; Norimichi Nakahata; Yasushi Ohizumi
Inhibitory effect of Mao-Bushi-Saishin-to on prostaglandin E2 synthesis in C6 rat glioma cells.
Biological & pharmaceutical bulletin 2004;27(7):1133-5.
2004: Yushan Li; Yasushi Ohizumi
Search for constituents with neurotrophic factor-potentiating activity from the medicinal plants of paraguay and Thailand.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2004;124(7):417-24.
2004: Hironori Fujiwara; Shin-ya Saito; Yukio Hitotsuyanagi; Koichi Takeya; Yasushi Ohizumi
RA-VII, a cyclic depsipeptide, changes the conformational structure of actin to cause G2 arrest by the inhibition of cytokinesis.
Cancer letters 2004;209(2):223-9.
2004: Shin-ya Saito; Yukiko Maruyama; Sachie Kamiyama; Norimichi Nakahata; Yasushi Ohizumi
Ephedrae herba in Mao-Bushi-Saishin-To inhibits IgE-mediated histamine release and increases cAMP content in RBL-2H3 cells.
Journal of pharmacological sciences 2004;95(1):41-6.
2004: Ayumi Sato; Hironori Fujiwara; Hisae Oku; Kyoko Ishiguro; Yasushi Ohizumi
Alpha-mangostin induces Ca2+-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells.
Journal of pharmacological sciences 2004;95(1):33-40.
2004: Satoshi Taniguchi; Ken-Ichi Furukawa; Satoshi Sasamura; Yasushi Ohizumi; Kazuhiko Seya; Shigeru Motomura
Gene expression and functional activity of sodium/calcium exchanger enhanced in vascular smooth muscle cells of spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 2004;43(5):629-37.
2004: Dileep Kumar Rohra; Tohru Yamakuni; Saiko Ito; Shin-Ya Saito; Yasushi Ohizumi
Evidence for the involvement of protein kinase C in acidic pH-induced contraction in spontaneously hypertensive rat aorta.
Pharmacology 2004;71(1):10-6.
2004: Yushan Li; Xigui Chen; Masayuki Satake; Yasukatsu Oshima; Yasushi Ohizumi
Acetylated flavonoid glycosides potentiating NGF action from Scoparia dulcis.
Journal of natural products 2004;67(4):725-7.
2003: Ping Li; Kimihiro Matsunaga; Tohru Yamakuni; Yasushi Ohizumi
Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells.
Brain research. Developmental brain research 2003;145(2):177-83.
2003: Dileep Kumar Rohra; Shin-ya Saito; Yasushi Ohizumi
Mechanism of acidic pH-induced contraction in spontaneously hypertensive rat aorta: role of Ca2+ release from the sarcoplasmic reticulum.
Acta physiologica Scandinavica 2003;179(3):273-80.
2003: Wisinee Chanmahasathien; Yushan Li; Masayuki Satake; Yasukatsu Oshima; Masami Ishibashi; Nijsiri Ruangrungsi; Yasushi Ohizumi
Prenylated xanthones from Garcinia xanthochymus.
Chemical & pharmaceutical bulletin 2003;51(11):1332-4.
2003: Wisinee Chanmahasathien; Yushan Li; Masayuki Satake; Yasukatsu Oshima; Nijsiri Ruangrungsi; Yasushi Ohizumi
Prenylated xanthones with NGF-potentiating activity from Garcinia xanthochymus.
Phytochemistry 2003;64(5):981-6.
2003: Hisatoshi Tsuchida; Yasushi Ohizumi
(+)-Nantenine isolated from Nandina domestica Thunb. inhibits adrenergic pressor responses in pithed rats.
European journal of pharmacology 2003;477(1):53-8.
2003: Ping Li; Tohru Yamakuni; Kimihiro Matsunaga; Shunzo Kondo; Yasushi Ohizumi
Nardosinone enhances nerve growth factor-induced neurite outgrowth in a mitogen-activated protein kinase- and protein kinase C-dependent manner in PC12D cells.
Journal of pharmacological sciences 2003;93(1):122-5.
2003: Yushan Li; Masami Ishibashi; Masayuki Satake; Yasukatsu Oshima; Yasushi Ohizumi
A new iridoid glycoside with nerve growth factor-potentiating activity, gelsemiol 6'-trans-caffeoyl-1-glucoside, from Verbena littoralis.
Chemical & pharmaceutical bulletin 2003;51(9):1103-5.
2003: Dileep Kumar Rohra; Shin-ya Saito; Yasushi Ohizumi
Strain-specific effects of acidic pH on contractile state of aortas from Wistar and Wistar Kyoto rats.
European journal of pharmacology 2003;476(1-2):123-30.
2003: Yasuo Kodama; Lv Xiaochuan; Chikako Tsuchiya; Yasushi Ohizumi; Makoto Yoshida; Norimichi Nakahata
Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells.
Planta medica 2003;69(8):765-7.
2003: Yushan Li; Masami Ishibashi; Xigui Chen; Yasushi Ohizumi
Littorachalcone, a new enhancer of NGF-mediated neurite outgrowth, from Verbena littoralis.
Chemical & pharmaceutical bulletin 2003;51(7):872-4.
2003: Yushan Li; Masami Ishibashi; Masayuki Satake; Xigui Chen; Yasukatsu Oshima; Yasushi Ohizumi
Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity.
Journal of natural products 2003;66(5):696-8.
2003: Yutaka Hirata; Masanori Atsumi; Yasushi Ohizumi; Norimichi Nakahata
Mastoparan binds to glycogen phosphorylase to regulate sarcoplasmic reticular Ca2+ release in skeletal muscle.
The Biochemical journal 2003;371(Pt 1):81-8.
2003: Dileep Kumar Rohra; Shin-ya Saito; Yasushi Ohizumi
Extracellular acidosis results in higher intracellular acidosis and greater contraction in spontaneously hypertensive rat aorta.
European journal of pharmacology 2003;465(1-2):141-4.
2003: Norimichi Nakahata; Chikako Tsuchiya; Keigo Nakatani; Yasushi Ohizumi; Satoko Ohkubo
Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells.
European journal of pharmacology 2003;461(1):1-7.
2003: Dileep Kumar Rohra; Shin-ya Saito; Yasushi Ohizumi
Functional role of ryanodine-sensitive Ca2+ stores in acidic pH-induced contraction in Wistar Kyoto rat aorta.
Life sciences 2003;72(11):1259-69.
2002: Dileep Kumar Rohra; Tohru Yamakuni; Ken-Ichi Furukawa; Noe Ishii; Takashi Shinkawa; Toshiaki Isobe; Yasushi Ohizumi
Stimulated tyrosine phosphorylation of phosphatidylinositol 3-kinase causes acidic pH-induced contraction in spontaneously hypertensive rat aorta.
The Journal of pharmacology and experimental therapeutics 2002;303(3):1255-64.
2002: Tohru Yamakuni; Michio Hashimoto; Hiroyuki Sakagami; Toshifumi Yamamoto; Masumi Kobayashi; Yoshimi Fujii; Hideko Yamamoto; Dileep Kumar Rohra; Yusuke Hiwatashi; Takao Honma; Hisatake Kondo; Osamu Shido; Yasushi Ohizumi
Expression of V-1, a novel catecholamine biosynthesis regulatory protein, is enhanced by hypertension in atrial myocytes of Dahl salt-sensitive rats.
Biochemical and biophysical research communications 2002;298(5):793-7.
2002: Minori MiTSUI-SAITO; Satoko Ohkubo; Yutaro Obara; Teruyuki Yanagisawa; Jun'Ichi Kobayashi; Yasushi Ohizumi; Norimichi Nakahata
Theonezolide A, a novel marine macrolide, induces drastic shape change in rabbit platelets by reorganization of microtubules.
Thrombosis research 2002;108(2-3):133-8.
2002: Tohru Yamakuni; Takahiro Suzuki; Hideo Inagaki; Yasushi Ohizumi; Toshiharu Nagatsu; Hiroshi Ichinose
[V-1, a catecholamine biosynthesis regulatory protein, enhances GTP cyclohydrolase I gene transcription in a cAMP-responsive element dependent manner].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(1):82P-84P.
2002: Dileep Kumar Rohra; Shin-ya Saito; Yasushi Ohizumi
Functional role of Cl- channels in acidic pH-induced contraction of the aorta of spontaneously hypertensive and Wistar Kyoto rats.
European journal of pharmacology 2002;453(2-3):279-86.
2002: Tohru Yamakuni; Toshifumi Yamamoto; Yukisato Ishida; Hideko Yamamoto; Si Young Song; Eijiro Adachi; Yusuke Hiwatashi; Yasushi Ohizumi
V-1, a catecholamine biosynthesis regulatory protein, positively controls catecholamine secretion in PC12D cells.
FEBS letters 2002;530(1-3):94-8.
2002: Satoshi Sasamura; Ken-Ichi Furukawa; Miwa Shiratori; Shigeru Motomura; Yasushi Ohizumi
Antisense-inhibition of plasma membrane Ca2+ pump induces apoptosis in vascular smooth muscle cells.
Japanese journal of pharmacology 2002;90(2):164-72.
2002: Yusuke Hiwatashi; Yusuke Kurahashi; Risa Hatada; Susumu Ueno; Takao Honma; Nobuyuki Yanagihara; Haruko Yanase; Toshihiko Iwanaga; Yasushi Ohizumi; Tohru Yamakuni
Glucocorticoid inhibits expression of V-1, a catecholamine biosynthesis regulatory protein, in cultured adrenal medullary cells.
FEBS letters 2002;528(1-3):166-70.
2002: Keigo Nakatani; Masanori Atsumi; Tsutomu Arakawa; Kenji Oosawa; Susumu Shimura; Norimichi Nakahata; Yasushi Ohizumi
Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant.
Biological & pharmaceutical bulletin 2002;25(9):1137-41.
2002: Ping Li; Kimihiro Matsunaga; Tohru Yamakuni; Yasushi Ohizumi
Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells.
Life sciences 2002;71(15):1821-35.
2002: Bachtiar Indra; Kimihiro Matsunaga; Osamu Hoshino; Masaji Suzuki; Hiromichi Ogasawara; Ikunobu Muramatsu; Takanobu Taniguchi; Yasushi Ohizumi
(+/-)-Domesticine, a novel and selective alpha1D-adrenoceptor antagonist in animal tissues and human alpha 1-adrenoceptors.
European journal of pharmacology 2002;445(1-2):21-9.
2002: Yutaro Obara; Takashi Aoki; Masayoshi Kusano; Yasushi Ohizumi
Beta-eudesmol induces neurite outgrowth in rat pheochromocytoma cells accompanied by an activation of mitogen-activated protein kinase.
The Journal of pharmacology and experimental therapeutics 2002;301(3):803-11.
2002: Bachtiar Indra; Takeshi Tadano; Osamu Nakagawasai; Yuichiro Arai; Hajime Yasuhara; Yasushi Ohizumi; Kensuke Kisara
Suppressive effect of nantenine, isolated from Nandina domestica Thunberg, on the 5-hydroxy-L-tryptophan plus clorgyline-induced head-twitch response in mice.
Life sciences 2002;70(22):2647-56.
2002: Bachtiar Indra; Kimihiro Matsunaga; Osamu Hoshino; Masaji Suzuki; Hiromichi Ogasawara; Masaji Ishiguro; Yasushi Ohizumi
Structure-activity relationship on (+/-)-nantenine derivatives in antiserotonergic activities in rat aorta.
Canadian journal of physiology and pharmacology 2002;80(3):198-204.
2002: Bachtiar Indra; Kimihiro Matsunaga; Osamu Hoshino; Masaji Suzuki; Hiromichi Ogasawara; Yasushi Ohizumi
Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity.
European journal of pharmacology 2002;437(3):173-8.
2002: E Candra; Kimihiro Matsunaga; Hironori Fujiwara; Y Mimaki; M Kuroda; Y Sashida; Yasushi Ohizumi
Potent apoptotic effects of saponins from Liliaceae plants in L1210 cells.
The Journal of pharmacy and pharmacology 2002;54(2):257-62.
2002: Mayumi Abe; Daisuke Inoue; Kimihiro Matsunaga; Yasushi Ohizumi; Hiroshi Ueda; Tomiko Asano; Masahiro Murakami; Yasufumi Sato
Goniodomin A, an antifungal polyether macrolide, exhibits antiangiogenic activities via inhibition of actin reorganization in endothelial cells.
Journal of cellular physiology 2002;190(1):109-16.
2002: Keigo Nakatani; Norimichi Nakahata; Tsutomu Arakawa; Hideyuki Yasuda; Yasushi Ohizumi
Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells.
Biochemical pharmacology 2002;63(1):73-9.
2001: Keigo Nakatani; Norimichi Nakahata; S Tsurufuji; Yasushi Ohizumi
Preconditioning of 3T3 cells by fresh medium together with genistein enhances prostaglandin E(2) release.
European journal of pharmacology 2001;432(2-3):135-42.
2001: T Moriya; K Furukawa; H Nakamura; A Murai; Yasushi Ohizumi
The vaso-contractile action of zooxanthellatoxin-B from a marine dinoflagellate is mediated via Ca2+ influx in the rabbit aorta.
Canadian journal of physiology and pharmacology 2001;79(12):1030-5.
2001: S Iwata; Shin-ya Saito; K Kon-ya; Y Shizuri; Yasushi Ohizumi
Novel marine-derived halogen-containing gramine analogues induce vasorelaxation in isolated rat aorta.
European journal of pharmacology 2001;432(1):63-70.
2001: E Candra; Kimihiro Matsunaga; Hironori Fujiwara; Y Mimaki; Y Sashida; Tohru Yamakuni; Yasushi Ohizumi
Two steroidal saponins from Camassia cusickii induce L1210 cell death through the apoptotic mechanism.
Canadian journal of physiology and pharmacology 2001;79(11):953-8.
2001: T Pengsuparp; Bachtiar Indra; Osamu Nakagawasai; Takeshi Tadano; Y Mimaki; Y Sashida; Yasushi Ohizumi; Kensuke Kisara
Pharmacological studies of geissoschizine methyl ether, isolated from Uncaria sinensis Oliv., in the central nervous system.
European journal of pharmacology 2001;425(3):211-8.
2001: Y S Li; Kimihiro Matsunaga; R Kato; Yasushi Ohizumi
Potentiation of nerve growth factor-induced elongation of neurites by gelsemiol and 9-hydroxysemperoside aglucone in PC12D cells.
The Journal of pharmacy and pharmacology 2001;53(6):915-9.
2001: Y S Li; Kimihiro Matsunaga; R Kato; Yasushi Ohizumi
Verbenachalcone, a novel dimeric dihydrochalcone with potentiating activity on nerve growth factor-action from Verbena littoralis.
Journal of natural products 2001;64(6):806-8.
2001: Yutaro Obara; H Kobayashi; T Ohta; Yasushi Ohizumi; Norimichi Nakahata
Scabronine G-methylester enhances secretion of neurotrophic factors mediated by an activation of protein kinase C-zeta.
Molecular pharmacology 2001;59(5):1287-97.
2001: Y Ohi; K Atsuki; Y Tori; Yasushi Ohizumi; Minoru Watanabe; Yuji Imaizumi
Imaging of Ca2+ release by caffeine and 9-methyl-7-bromoeudistomin D and the associated activation of large conductance Ca2+-dependent K+ channels in urinary bladder smooth muscle cells of the guinea pig.
Japanese journal of pharmacology 2001;85(4):382-90.
2001: Y S Li; Kimihiro Matsunaga; M Ishibashi; Yasushi Ohizumi
Littoralisone, a novel neuritogenic iridolactone having an unprecedented heptacyclic skeleton including four- and nine-membered rings consisting of glucose from Verbena littoralis.
The Journal of organic chemistry 2001;66(6):2165-7.
2001: H Fujiwara; Kimihiro Matsunaga; M Saito; S Hagiya; K Furukawa; H Nakamura; Yasushi Ohizumi
Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells.
European journal of pharmacology 2001;413(1):37-45.
2000: Ping Li; Kimihiro Matsunaga; Tohru Yamakuni; Yasushi Ohizumi
Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells.
European journal of pharmacology 2000;406(2):203-8.
2000: Yutaro Obara; Norimichi Nakahata; Y Mizushina; F Sugawara; K Sakaguchi; Yasushi Ohizumi
Differentiation of rat pheochromocytoma cells by fomitellic acids, specific DNA polymerase inhibitors.
Life sciences 2000;67(13):1659-65.
2000: Ping Li; Kimihiro Matsunaga; Yasushi Ohizumi
Nerve growth factor-potentiating compounds from Picrorhizae Rhizoma.
Biological & pharmaceutical bulletin 2000;23(7):890-2.
2000: Yutaka Hirata; Norimichi Nakahata; Yasushi Ohizumi
Identification of a 97-kDa mastoparan-binding protein involving in Ca(2+) release from skeletal muscle sarcoplasmic reticulum.
Molecular pharmacology 2000;57(6):1235-42.
2000: A Seino-Umeda; M Ishibashi; Jun'ichi Kobayashi; Yasushi Ohizumi
Structure-activity relationships for the Ca2+-releasing activity of 6-hydroxy-beta-carboline analogues in skeletal muscle sarcoplasmic reticulum-the effects of halogen substitution at C-5 and C-7.
The Journal of pharmacy and pharmacology 2000;52(5):517-21.
2000: H Kobayashi; S Honma; Norimichi Nakahata; Yasushi Ohizumi
Involvement of phosphatidylcholine-specific phospholipase C in thromboxane A2-induced activation of mitogen-activated protein kinase in astrocytoma cells.
Journal of neurochemistry 2000;74(5):2167-73.
2000: Minori MiTSUI-SAITO; Norimichi Nakahata; Yasushi Ohizumi
Inhibition of microtubule polymerization by SK&F 96365, a blocker of receptor-linked Ca2+ entry.
Japanese journal of pharmacology 2000;82(3):269-71.
2000: Norimichi Nakahata; H Takano; Yasushi Ohizumi
Thromboxane A2 receptor-mediated tonic contraction is attributed to an activation of phosphatidylcholine-specific phospholipase C in rabbit aortic smooth muscles.
Life sciences 2000;66(5):PL 71-6.
1999: R Kyo; Norimichi Nakahata; Y Kodama; Y Nakai; M Kubo; Yasushi Ohizumi
Antagonism of saikosaponin-induced prostaglandin E2 release by baicalein in C6 rat glioma cells.
Biological & pharmaceutical bulletin 1999;22(12):1385-7.
1999: Kimihiro Matsunaga; K Nakatani; M Murakami; K Yamaguchi; Yasushi Ohizumi
Powerful activation of skeletal muscle actomyosin ATPase by goniodomin A is highly sensitive to troponin/tropomyosin complex.
The Journal of pharmacology and experimental therapeutics 1999;291(3):1121-6.
1999: M Ito; Yutaka Hirata; H Nakamura; Yasushi Ohizumi
Xestoquinone, isolated from sea sponge, causes Ca(2+) release through sulfhydryl modification from skeletal muscle sarcoplasmic reticulum.
The Journal of pharmacology and experimental therapeutics 1999;291(3):976-81.
1999: Keigo Nakatani; T Murayama; Y Satoh; K I Furukawa; S Omura; Yasushi Ohizumi
Modulation of actomyosin ATPase by thiotetromycin is mediated through conformational change of actin.
European journal of pharmacology 1999;383(3):381-6.
1999: Norimichi Nakahata; Y Harada; M Tsuji; K Kon-ya; Y Shizuri; Yasushi Ohizumi
Structure-activity relationship of gramine derivatives in Ca(2+) release from sarcoplasmic reticulum.
European journal of pharmacology 1999;382(2):129-32.
1999: Kimihiro Matsunaga; K Nakatani; M Murakami; Norimichi Nakahata; Yasushi Ohizumi
[Goniodomin A induces modulation of actomyosin ATPase activity mediated through conformational change of actin].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():220P-224P.
1999: Norimichi Nakahata; R Kyo; M Kutsuwa; Yasushi Ohizumi
[Inhibition of mitogen-activated protein kinase cascade by baicalein, a flavonoid of natural origin].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():215P-219P.
1999: Norimichi Nakahata; T Yaginuma; Yasushi Ohizumi
Maitotoxin-induced phosphoinositide hydrolysis is dependent on extracellular but not intracellular Ca2+ in human astrocytoma cells.
Japanese journal of pharmacology 1999;81(2):240-3.
1999: Yutaka Hirata; M Ito; Toshiaki Nikai; S Kato; Yumiko Komori; H Sugiura; Yasushi Ohizumi
Himehabu lectin, a novel inducer of Ca2+-release from the venom of the snake Trimeresurus okinavensis, in sarcoplasmic reticulum.
The Journal of pharmacy and pharmacology 1999;51(10):1207-11.
1999: Norimichi Nakahata; S Ohkubo; E Ito; M Nakano; K Terao; Yasushi Ohizumi
Comparison of maitotoxin with thromboxane A2 in rabbit platelet activation.
Toxicon : official journal of the International Society on Toxinology 1999;37(10):1375-89.
1999: P Li; K Matsunaga; K Yamamoto; R Yoshikawa; K Kawashima; Yasushi Ohizumi
Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells.
Neuroscience letters 1999;273(1):53-6.
1999: Yutaka Hirata; N Nakahata; M Ohkura; Yasushi Ohizumi
Identification of 30 kDa protein for Ca(2+) releasing action of myotoxin a with a mechanism common to DIDS in skeletal muscle sarcoplasmic reticulum.
Biochimica et biophysica acta 1999;1451(1):132-40.
1999: S Honma; Norimichi Nakahata; H Kobayashi; S Ikeda; N Takeda; Yasushi Ohizumi
Decrease in thromboxane A2 receptor expression by differentiation with dibutyryl cyclic AMP in 1321N1 human astrocytoma cells.
Prostaglandins & other lipid mediators 1999;58(1):51-62.
1999: Yutaro Obara; M Takahashi; Norimichi Nakahata; Yasushi Ohizumi
Maitotoxin-induced nerve growth factor production accompanied by the activation of a voltage-insensitive Ca2+ channel in C6-BU-1 glioma cells.
British journal of pharmacology 1999;127(7):1577-82.
1999: Ping Li; Kimihiro Matsunaga; Yasushi Ohizumi
Enhancement of the nerve growth factor-mediated neurite outgrowth from PC12D cells by Chinese and Paraguayan medicinal plants.
Biological & pharmaceutical bulletin 1999;22(7):752-5.
1999: Norimichi Nakahata; H Takano; Yasushi Ohizumi
Thromboxane A2-induced phosphatidylcholine hydrolysis in porcine vascular smooth muscle cells.
European journal of pharmacology 1999;374(1):157-60.
1999: A Suzuki; Kimihiro Matsunaga; Yoshihiro Mimaki; Yutaka Sashida; Yasushi Ohizumi
Properties of amentoflavone, a potent caffeine-like Ca2+ releaser in skeletal muscle sarcoplasmic reticulum.
European journal of pharmacology 1999;372(1):97-102.
1999: Akihiko Kuniyasu; S Kawano; Y Hirayama; Y H Ji; K Xu; M Ohkura; K Furukawa; Yasushi Ohizumi; M Hiraoka; Hitoshi Nakayama
A new scorpion toxin (BmK-PL) stimulates Ca2+-release channel activity of the skeletal-muscle ryanodine receptor by an indirect mechanism.
The Biochemical journal 1999;339 ( Pt 2)():343-50.
1999: Yasushi Ohizumi; Yutaka Hirata; A Suzuki; M Kobayashi
Two novel types of calcium release from skeletal sarcoplasmic reticulum by phosphatidylinositol 4,5-biphosphate.
Canadian journal of physiology and pharmacology 1999;77(4):276-85.
1999: Yutaro Obara; Norimichi Nakahata; T Kita; Yoshiaki Takaya; H Kobayashi; Shinzo Hosoi; Fumiyuki Kiuchi; T Ohta; Yoshiteru Oshima; Yasushi Ohizumi
Stimulation of neurotrophic factor secretion from 1321N1 human astrocytoma cells by novel diterpenoids, scabronines A and G.
European journal of pharmacology 1999;370(1):79-84.
1999: Kimihiro Matsunaga; K Nakatani; M Ishibashi; Jun'ichi Kobayashi; Yasushi Ohizumi
Amphidinolide B, a powerful activator of actomyosin ATPase enhances skeletal muscle contraction.
Biochimica et biophysica acta 1999;1427(1):24-32.
1998: Norimichi Nakahata; S Honma; H Kobayashi; Yasushi Ohizumi
[Thromboxane A2 receptor-mediated signal transduction in glial cells].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1998;112 Suppl 1():113P-117P.
1998: K Tsukii; Norimichi Nakahata; S Tsurufuji; Yasushi Ohizumi
Ca2+-independent synergistic augmentation of O2- production by FMLP and PMA in HL-60 cells.
Canadian journal of physiology and pharmacology 1998;76(10-11):1024-32.
1998: R Kyo; Norimichi Nakahata; I Sakakibara; M Kubo; Yasushi Ohizumi
Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on intracellular Ca2+ mobilization in C6 rat glioma cells.
Biological & pharmaceutical bulletin 1998;21(10):1067-71.
1998: R Kyo; Norimichi Nakahata; I Sakakibara; M Kubo; Yasushi Ohizumi
Baicalin and baicalein, constituents of an important medicinal plant, inhibit intracellular Ca2+ elevation by reducing phospholipase C activity in C6 rat glioma cells.
The Journal of pharmacy and pharmacology 1998;50(10):1179-82.
1998: M Ohkura; K Furukawa; H Fujimori; A Kuruma; S Kawano; M Hiraoka; Akihiko Kuniyasu; Hitoshi Nakayama; Yasushi Ohizumi
Dual regulation of the skeletal muscle ryanodine receptor by triadin and calsequestrin.
Biochemistry 1998;37(37):12987-93.
1998: Keigo Nakatani; Norimichi Nakahata; Y Hamada; S Tsurufuji; Yasushi Ohizumi
Medium change amplifies mitogen-activated protein kinase-mediated prostaglandin E2 synthesis in Swiss 3T3 fibroblasts.
European journal of pharmacology 1998;356(1):91-100.
1998: M Kutsuwa; Norimichi Nakahata; K Hayashi; M Kubo; Yasushi Ohizumi
A comparative study of Kakkon-to and Keishi-to on prostaglandin E(2) release from rabbit astrocytes.
Phytomedicine : international journal of phytotherapy and phytopharmacology 1998;5(4):275-82.
1998: K Mizuno; Norimichi Nakahata; E Ito; M Murakami; K Yamaguchi; Yasushi Ohizumi
Goniodomin A, an antifungal polyether macrolide, increases the filamentous actin content of 1321N1 human astrocytoma cells.
The Journal of pharmacy and pharmacology 1998;50(6):645-8.
1998: T Moriya; Y Ishida; H Nakamura; T Asari; A Murai; Yasushi Ohizumi
Vasoconstriction induced by zooxanthellatoxin-B, a polyoxygenated long-chain product from a marine alga.
European journal of pharmacology 1998;350(1):59-65.
1998: Yasushi Ohizumi; Kimihiro Matsunaga; K Nakatani; Jun'ichi Kobayashi
Potent stimulation of myofilament force and ATPase activity of skeletal muscle by eudistomin M, a novel Ca(++)-sensitizing agent from a Caribbean tunicate.
The Journal of pharmacology and experimental therapeutics 1998;285(2):695-9.
1998: C Katagiri; H H Ishikawa; M Ohkura; Osamu Nakagawasai; Takeshi Tadano; Kensuke Kisara; Yasushi Ohizumi
Properties of specific binding site of myotoxin a, a powerful convulsant, in brain microsomes.
Canadian journal of physiology and pharmacology 1998;76(4):395-400.
1998: K Mizuno; Norimichi Nakahata; Yasushi Ohizumi
Characterization of mastoparan-induced histamine release from RBL-2H3 cells.
Toxicon : official journal of the International Society on Toxinology 1998;36(3):447-56.
1998: Norimichi Nakahata; M Kutsuwa; R Kyo; M Kubo; K Hayashi; Yasushi Ohizumi
Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells.
The American journal of Chinese medicine 1998;26(3-4):311-23.
1998: MC Rho; Norimichi Nakahata; Yasushi Ohizumi
Two distinct effects of 12S-hydroxyeicosatetraenoic acid on platelet aggregation by zooxanthellatoxin-A and ionomycin.
Japanese journal of pharmacology 1998;76(1):117-20.
1998: Yasushi Ohizumi; Kimihiro Matsunaga; K Nakatani; Jun'ichi Kobayashi
The powerful stimulatory action of 6-O-acetyl-9-methyl-7-bromoeudistomin D on the contractile protein system of rabbit skeletal muscle.
Japanese journal of pharmacology 1998;76(1):113-6.
1998: N Chairungsrilerd; K I Furukawa; T Ohta; S Nozoe; Yasushi Ohizumi
Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(1):25-31.
1997: Y I Fang; Etsuo Yokota; Issei Mabuchi; H Nakamura; Yasushi Ohizumi
Purealin blocks the sliding movement of sea urchin flagellar axonemes by selective inhibition of half the ATPase activity of axonemal dyneins.
Biochemistry 1997;36(50):15561-7.
1997: Ken-Ichi Furukawa; M Matsuzawa; S Tsurufuji; K Watanabe; Yasushi Ohizumi
The mechanism of rabbit platelet aggregation induced by 2,5-di-(tert-butyl)-1,4-benzohydroquinone, an inhibitor of endoplasmic reticulum Ca2+-ATPase.
Japanese journal of pharmacology 1997;75(3):295-8.
1997: Norimichi Nakahata; MC Rho; Yasushi Ohizumi
[Effect of zooxanthellatoxin-A, an unique marine product, on arachidonic acid cascade in rabbit platelets].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1997;110 Suppl 1():189P-194P.
1997: K Furukawa; N Chairungsrilerd; T Ohta; S Nozoe; Yasushi Ohizumi
[Novel types of receptor antagonists from the medicinal plant Garcinia mangostana].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1997;110 Suppl 1():153P-158P.
1997: MC Rho; Norimichi Nakahata; H Nakamura; A Murai; Yasushi Ohizumi
Involvement of phospholipase C-gamma2 in activation of mitogen-activated protein kinase and phospholipase A2 by zooxanthellatoxin-A in rabbit platelets.
The Journal of pharmacology and experimental therapeutics 1997;282(1):496-504.
1997: Yasushi Ohizumi
Application of physiologically active substances isolated from natural resources to pharmacological studies.
Japanese journal of pharmacology 1997;73(4):263-89.
1997: MC Rho; Norimichi Nakahata; H Nakamura; A Murai; Yasushi Ohizumi
Tyrphostin 23 blocks phosphorylation of p42 but not p38 mitogen-activated protein kinase by zooxanthellatoxin-A.
European journal of pharmacology 1997;319(2-3):375-8.
1996: MC Rho; K Matsunaga; Y H Park; K Yasuda; T Yamasu; S Mayama; Yasushi Ohizumi
A sulfonoglycolipid with Na+,K+-ATPase inhibitory activity, produced by a cultured unique diatom symbiont isolated from a larger foraminifera.
Planta medica 1996;62(6):552-4.
1996: S Ohkubo; N Nakahata; Yasushi Ohizumi
Thromboxane A2 stimulates mitogen-activated protein kinase and arachidonic acid liberation in rabbit platelets.
Prostaglandins 1996;52(5):403-13.
1996: N Chairungsrilerd; K Furukawa; T Ohta; S Nozoe; Yasushi Ohizumi
Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist.
European journal of pharmacology 1996;314(3):351-6.
1996: N Chairungsrilerd; K Furukawa; T Ohta; S Nozoe; Yasushi Ohizumi
Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana.
Planta medica 1996;62(5):471-2.
1996: Yasushi Ohizumi; S Sasaki; K Shibusawa; K Ishikawa; F Ikemoto
Stimulation of sarcoplasmic reticulum Ca(2+)-ATPase by gingerol analogues.
Biological & pharmaceutical bulletin 1996;19(10):1377-9.
1996: Yasushi Ohizumi; S Sasaki; T Kusumi; I I Ohtani
Ptilomycalin A, a novel Na+, K(+)- or Ca2(+)-ATPase inhibitor, competitively interacts with ATP at its binding site.
European journal of pharmacology 1996;310(1):95-8.
1996: K Furukawa; K Shibusawa; N Chairungsrilerd; T Ohta; S Nozoe; Yasushi Ohizumi
The mode of inhibitory action of alpha-mangostin, a novel inhibitor, on the sarcoplasmic reticulum Ca(2+)-pumping ATPase from rabbit skeletal muscle.
Japanese journal of pharmacology 1996;71(4):337-40.
1996: K Furukawa; J Komaba; H Sakai; Yasushi Ohizumi
The mechanism of acidic pH-induced contraction in aortae from SHR and WKY rats enhanced by increasing blood pressure.
British journal of pharmacology 1996;118(3):485-92.
1996: M Ohkura; Y Miyashita; M Kakubari; Y Hayakawa; H Seto; Yasushi Ohizumi
Characteristics of 45Ca2+ release induced by quinolidomicin A1, a 60-membered macrolide from skeletal muscle sarcoplasmic reticulum.
Biochimica et biophysica acta 1996;1294(2):177-82.
1996: M Ohkura; Y Miyashita; Toshiaki Nikai; J Suzuki; Yumiko Komori; H Sugihara; Yasushi Ohizumi
Properties of Ca++ release induced by puff adder lectin, a novel lectin from the snake Bitis arietans, in sarcoplasmic reticulum.
The Journal of pharmacology and experimental therapeutics 1996;277(2):1043-8.
1996: S Ohkubo; N Nakahata; Yasushi Ohizumi
ML-7 and W-7 facilitate thromboxane A2-mediated Ca2+ mobilization in rabbit platelets.
European journal of pharmacology 1996;298(2):175-83.
1996: S Ohkubo; N Nakahata; Yasushi Ohizumi
Thromboxane A2-mediated shape change: independent of Gq-phospholipase C--Ca2+ pathway in rabbit platelets.
British journal of pharmacology 1996;117(6):1095-104.
1996: MC Rho; K Matsunaga; K Yasuda; Yasushi Ohizumi
A novel monogalactosylacylglycerol with inhibitory effect on platelet aggregation from the cyanophyceae Oscillatoria rosea.
Journal of natural products 1996;59(3):308-9.
1996: K Tsukii; N Nakahata; K Watanabe; S Tsurufuji; Yasushi Ohizumi
Comparison of tBuBHQ with chemotactic peptide and phorbol ester in O2- production in HL-60 cells.
European journal of pharmacology 1996;298(1):87-95.
1996: MC Rho; Y H Park; S Sasaki; M Ishibashi; K Kondo; J Kobayashi; Yasushi Ohizumi
The mode of rabbit platelet shape change and aggregation induced by theonezolide-A, a novel polyketide macrolide, isolated from the Okinawan marine sponge Theonella sp.
Canadian journal of physiology and pharmacology 1996;74(2):193-9.
1996: K Sakai; N Nakahata; H Ono; T Yamamoto; Yasushi Ohizumi
Homologous desensitization of thromboxane A2 receptor in 1321N1 human astrocytoma cells.
The Journal of pharmacology and experimental therapeutics 1996;276(2):829-36.
1996: N Nakahata; K Imata; T Okawa; Y Watanabe; H Ishimoto; T Ono; Yasushi Ohizumi; Hironori Nakanishi
Mastoparan elicits prostaglandin E2 generation and inhibits inositol phosphate accumulation via different mechanisms in rabbit astrocytes.
Biochimica et biophysica acta 1996;1310(1):60-6.
1995: Toshiaki Nikai; J Suzuki; Yumiko Komori; M Ohkura; Yasushi Ohizumi; H Sugihara
Primary structure of the lectin from the venom of Bitis arietans (puff-adder).
Biological & pharmaceutical bulletin 1995;18(11):1620-2.
1995: K Yoshikawa; K Furukawa; M Yamamoto; K Momose; Yasushi Ohizumi
[3H]9-Methyl-7-bromoeudistomin D, a caffeine-like powerful Ca2+ releaser, binds to caffeine-binding sites distinct from the ryanodine receptors in brain microsomes.
FEBS letters 1995;373(3):250-4.
1995: H Sakamoto; K Furukawa; K Matsunaga; H Nakamura; Yasushi Ohizumi
Xestoquinone activates skeletal muscle actomyosin ATPase by modification of the specific sulfhydryl group in the myosin head probably distinct from sulfhydryl groups SH1 and SH2.
Biochemistry 1995;34(39):12570-5.
1995: K Mizuno; N Nakahata; Yasushi Ohizumi
Mastoparan-induced phosphatidylcholine hydrolysis by phospholipase D activation in human astrocytoma cells.
British journal of pharmacology 1995;116(3):2090-6.
1995: M Ohkura; T Ide; K Furukawa; T Kawasaki; M Kasai; Yasushi Ohizumi
Calsequestrin is essential for the Ca2+ release induced by myotoxin alpha in skeletal muscle sarcoplasmic reticulum.
Canadian journal of physiology and pharmacology 1995;73(8):1181-5.
1995: MC Rho; N Nakahata; H Nakamura; A Murai; Yasushi Ohizumi
Activation of rabbit platelets by Ca2+ influx and thromboxane A2 release in an external Ca(2+)-dependent manner by zooxanthellatoxin-A, a novel polyol.
British journal of pharmacology 1995;115(3):433-40.
1995: M Ohkura; K Furukawa; K Oikawa; Yasushi Ohizumi
The properties of specific binding site of 125I-radioiodinated myotoxin a, a novel Ca++ releasing agent, in skeletal muscle sarcoplasmic reticulum.
The Journal of pharmacology and experimental therapeutics 1995;273(2):934-9.
1995: N Nakahata; A Miyamoto; S Ohkubo; H Ishimoto; K Sakai; Hironori Nakanishi; H Ohshika; Yasushi Ohizumi
Gq/11 communicates with thromboxane A2 receptors in human astrocytoma cells, rabbit astrocytes and human platelets.
Research communications in molecular pathology and pharmacology 1995;87(3):243-51.
1995: Y Takahashi; K Furukawa; D Kozutsumi; M Ishibashi; Jun'ichi Kobayashi; Yasushi Ohizumi
4,6-Dibromo-3-hydroxycarbazole (an analogue of caffeine-like Ca2+ releaser), a novel type of inhibitor of Ca(2+)-induced Ca2+ release in skeletal muscle sarcoplasmic reticulum.
British journal of pharmacology 1995;114(5):941-8.
1995: Y Takahashi; K Furukawa; M Ishibashi; D Kozutsumi; H Ishiyama; Jun'ichi Kobayashi; Yasushi Ohizumi
Structure-activity relationship of bromoeudistomin D, a powerful Ca2+ releaser in skeletal muscle sarcoplasmic reticulum.
European journal of pharmacology 1995;288(3):285-93.
1995: K Matsunaga; M Shibuya; Yasushi Ohizumi
Imperanene, a novel phenolic compound with platelet aggregation inhibitory activity from Imperata cylindrica.
Journal of natural products 1995;58(1):138-9.
1994: K Matsunaga; M Shibuya; Yasushi Ohizumi
Graminone B, a novel lignan with vasodilative activity from Imperata cylindrica.
Journal of natural products 1994;57(12):1734-6.
1994: M Adachi; M Kakubari; Yasushi Ohizumi
Tissue- and subcellular-distribution of the binding site of [3H]9- methyl-7-bromoeudistomin D, a potent caffeine-like Ca2+ releaser, in rabbits.
The Journal of pharmacy and pharmacology 1994;46(9):774-6.
1994: M Adachi; Y Fang; T Yamakuni; Jun'ichi Kobayashi; Yasushi Ohizumi
Properties of the binding sites of [3H]9-methyl-7-bromoeudistomin D in bovine aortic smooth muscle microsomes.
The Journal of pharmacy and pharmacology 1994;46(9):771-3.
1994: K Furukawa; K Funayama; M Ohkura; Y Oshima; A T Tu; Yasushi Ohizumi
Ca2+ release induced by myotoxin alpha, a radio-labellable probe having novel Ca2+ release properties in sarcoplasmic reticulum.
British journal of pharmacology 1994;113(1):233-9.
1994: K Matsunaga; M Ikeda; M Shibuya; Yasushi Ohizumi
Cylindol A, a novel biphenyl ether with 5-lipoxygenase inhibitory activity, and a related compound from Imperata Cylindrica.
Journal of natural products 1994;57(9):1290-3.
1994: K Matsunaga; M Shibuya; Yasushi Ohizumi
Cylindrene, a novel sesquiterpenoid from Imperata cylindrica with inhibitory activity on contractions of vascular smooth muscle.
Journal of natural products 1994;57(8):1183-4.
1994: A Seino; K Furukawa; T Miura; T Yaginuma; K Momose; Yasushi Ohizumi
3',3",5',5"-Tetraiodophenolsulfonephthalein is a selective inhibitor of Ca(2+)-pumping ATPase in intracellular Ca2+ store.
The Journal of biological chemistry 1994;269(26):17550-5.
1994: M Ohkura; K Furukawa; A T Tu; Yasushi Ohizumi
Calsequestrin is a major binding protein of myotoxin alpha and an endogenous Ca2+ releaser in sarcoplasmic reticulum.
European journal of pharmacology 1994;268(1):R1-2.
1994: N Nakahata; H Ishimoto; K Mizuno; Yasushi Ohizumi; Hironori Nakanishi
Dual effects of mastoparan on intracellular free Ca2+ concentrations in human astrocytoma cells.
British journal of pharmacology 1994;112(1):299-303.
1994: Y Oshima; S Yamada; K Matsunaga; T Moriya; Yasushi Ohizumi
A monogalactosyl diacylglycerol from a cultured marine dinoflagellate, Scrippsiella trochoidea.
Journal of natural products 1994;57(4):534-6.
1994: M Adachi; M Kakubari; Yasushi Ohizumi
The specific binding site of 9-[3H]methyl-7-bromoeudistomin D, a caffeine-like Ca2+ releaser, in liver microsomes in distinct from that in skeletal sarcoplasmic reticulum.
Biological chemistry Hoppe-Seyler 1994;375(3):183-7.
1994: Toshiaki Nikai; Yumiko Komori; A Ohara; S Yagihashi; Yasushi Ohizumi; H Sugihara
Characterization and amino-terminal sequence of phospholipase A2-II from the venom of Agkistrodon bilineatus (common cantil).
The International journal of biochemistry 1994;26(1):43-8.
1993: K Furukawa; K Sakai; S Watanabe; K Maruyama; M Murakami; K Yamaguchi; Yasushi Ohizumi
Goniodomin A induces modulation of actomyosin ATPase activity mediated through conformational change of actin.
The Journal of biological chemistry 1993;268(34):26026-31.
1993: A Subarnas; Takeshi Tadano; Kensuke Kisara; Yasushi Ohizumi
An alpha-adrenoceptor-mediated mechanism of hypoactivity induced by beta-amyrin palmitate.
The Journal of pharmacy and pharmacology 1993;45(11):1006-8.
1993: Y I Fang; M Adachi; Jun'ichi Kobayashi; Yasushi Ohizumi
High affinity binding of 9-[3H]methyl-7-bromoeudistomin D to the caffeine-binding site of skeletal muscle sarcoplasmic reticulum.
The Journal of biological chemistry 1993;268(25):18622-5.
1993: A Subarnas; Takeshi Tadano; Y Oshima; Kensuke Kisara; Yasushi Ohizumi
Pharmacological properties of beta-amyrin palmitate, a novel centrally acting compound, isolated from Lobelia inflata leaves.
The Journal of pharmacy and pharmacology 1993;45(6):545-50.
1993: A Watanabe; Y Ishida; H Honda; M Kobayashi; Yasushi Ohizumi
Ca(2+)-dependent aggregation of rabbit platelets induced by maitotoxin, a potent marine toxin, isolated from a dinoflagellate.
British journal of pharmacology 1993;109(1):29-36.
1993: Yasushi Ohizumi
[Tendency of development on novel type of cardiotonic drugs].
Nihon rinsho. Japanese journal of clinical medicine 1993;51(5):1299-304.
1993: H Nakamura; T Asari; Yasushi Ohizumi; J Kobayashi; T Yamasu; A Murai
Isolation of zooxanthellatoxins, novel vasoconstrictive substances from the zooxanthella Symbiodinium sp.
Toxicon : official journal of the International Society on Toxinology 1993;31(4):371-6.
1993: A Subarnas; Takeshi Tadano; N Nakahata; Y Arai; H Kinemuchi; Y Oshima; Kensuke Kisara; Yasushi Ohizumi
A possible mechanism of antidepressant activity of beta-amyrin palmitate isolated from Lobelia inflata leaves in the forced swimming test.
Life sciences 1993;52(3):289-96.
1992: Yasushi Ohizumi
[Novel types of cardiotonic drugs].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1992;100(3):259-69.
1992: A Subarnas; Y Oshima; Yasushi Ohizumi
An antidepressant principle of Lobelia inflata L. (Campanulaceae).
Journal of pharmaceutical sciences 1992;81(7):620-1.
1992: Yasushi Ohizumi
[Useful natural products for the biochemical study on muscle contractile systems].
Seikagaku. The Journal of Japanese Biochemical Society 1992;64(3):177-81.