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Yasushi Ohizumi

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
39
Nakahata, Norimichi
35
Yamakuni, Tohru
22
Matsunaga, Kimihiro
11
Ohkura, M
11
Li, Yushan
11
Saito, Shin-ya
10
Rohra, Dileep Kumar
10
Nakamura, H
9
Kobayashi, Jun'ichi
8
Rho, MC
8
Tadano, Takeshi
7
Sashida, Yutaka
7
Obara, Yutaro
7
Mimaki, Yoshihiro
7
Oshima, Yasukatsu

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Publications

TOP 3
Yamamoto Yui; Shioda Norifumi; Han Feng; Moriguchi Shigeki; Nakajima Akira; Yokosuka Akihito; Mimaki Yoshihiro; Sashida Yutaka; Yamakuni Tohru; Ohizumi Yasushi; Fukunaga Kohji
Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.
Al Rahim Md; Nakajima Akira; Saigusa Daisuke; Tetsu Naomi; Maruyama Yuji; Shibuya Masatoshi; Yamakoshi Hiroyuki; Tomioka Yoshihisa; Iwabuchi Yoshiharu; Ohizumi Yasushi; Yamakuni Tohru
4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.
Al Rahim Md; Nakajima Akira; Misawa Norihiko; Shindo Kazutoshi; Adachi Kyoko; Shizuri Yoshikazu; Ohizumi Yasushi; Yamakuni Tohru
A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Abeta-inhibition of the cascade in cultured rat CNS neurons.

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All Publications

2009: Yamamoto Yui; Shioda Norifumi; Han Feng; Moriguchi Shigeki; Nakajima Akira; Yokosuka Akihito; Mimaki Yoshihiro; Sashida Yutaka; Yamakuni Tohru; Ohizumi Yasushi; Fukunaga Kohji
Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.
Brain research 2009;1295():218-29.
2009: Al Rahim Md; Nakajima Akira; Saigusa Daisuke; Tetsu Naomi; Maruyama Yuji; Shibuya Masatoshi; Yamakoshi Hiroyuki; Tomioka Yoshihisa; Iwabuchi Yoshiharu; Ohizumi Yasushi; Yamakuni Tohru
4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.
Biochemistry 2009;48(32):7713-21.
2008: Al Rahim Md; Nakajima Akira; Misawa Norihiko; Shindo Kazutoshi; Adachi Kyoko; Shizuri Yoshikazu; Ohizumi Yasushi; Yamakuni Tohru
A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Abeta-inhibition of the cascade in cultured rat CNS neurons.
European journal of pharmacology 2008;600(1-3):10-7.
2008: Yamakuni Tohru; Nakajima Akira; Ohizumi Yasushi
Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, and its application for development of functional foods.
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2008;132(3):155-9.
2008: Onozuka Hiroshi; Nakajima Akira; Matsuzaki Kentaro; Shin Ryong-Woon; Ogino Koichi; Saigusa Daisuke; Tetsu Naomi; Yokosuka Akihito; Sashida Yutaka; Mimaki Yoshihiro; Yamakuni Tohru; Ohizumi Yasushi
Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease.
The Journal of pharmacology and experimental therapeutics 2008;326(3):739-44.
2008: Matsuzaki Kentaro; Miyazaki Kenichi; Sakai Seiichiro; Yawo Hiromu; Nakata Norihito; Moriguchi Shigeki; Fukunaga Kohji; Yokosuka Akihito; Sashida Yutaka; Mimaki Yoshihiro; Yamakuni Tohru; Ohizumi Yasushi
Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.
European journal of pharmacology 2008;578(2-3):194-200.
2007: Kitazawa Masashi; Ohizumi Yasushi; Oike Yuichi; Hishinuma Takanori; Hashimoto Seiichi
Angiopoietin-related growth factor suppresses gluconeogenesis through the Akt/forkhead box class O1-dependent pathway in hepatocytes.
The Journal of pharmacology and experimental therapeutics 2007;323(3):787-93.
2007: Guo Yuanqiang; Li Yushan; Xu Jing; Li Ning; Yamakuni Tohru; Ohizumi Yasushi
Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana.
Chemical & pharmaceutical bulletin 2007;55(10):1532-4.
2007: Nakajima Akira; Yamakuni Tohru; Haraguchi Mitsuya; Omae Naoki; Song Si-Young; Kato Chieko; Nakagawasai Osamu; Tadano Takeshi; Yokosuka Akihito; Mimaki Yoshihiro; Sashida Yutaka; Ohizumi Yasushi
Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.
Journal of pharmacological sciences 2007;105(1):122-6.
2007: Nakajima Akira; Yamakuni Tohru; Matsuzaki Kentaro; Nakata Norihito; Onozuka Hiroshi; Yokosuka Akihito; Sashida Yutaka; Mimaki Yoshihiro; Ohizumi Yasushi
Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by activation of extracellular signal-regulated kinase signaling.
The Journal of pharmacology and experimental therapeutics 2007;321(2):784-90.
2006: Kiyoshi Hidekazu; Yamazaki Daiju; Ohya Susumu; Kitsukawa Mika; Muraki Katsuhiko; Saito Shin-ya; Ohizumi Yasushi; Imaizumi Yuji
Molecular and electrophysiological characteristics of K+ conductance sensitive to acidic pH in aortic smooth muscle cells of WKY and SHR.
American journal of physiology. Heart and circulatory physiology 2006;291(6):H2723-34.
2006: Fujiwara Hironori; Iwasaki Koh; Furukawa Katsutoshi; Seki Takashi; He Mei; Maruyama Masahiro; Tomita Naoki; Kudo Yukitsuka; Higuchi Makoto; Saido Takaomi C; Maeda Sumihiro; Takashima Akihiko; Hara Masahiko; Ohizumi Yasushi; Arai Hiroyuki
Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins.
Journal of neuroscience research 2006;84(2):427-33.
2006: Koizumi Takayuki; Abe Mayumi; Yamakuni Tohru; Ohizumi Yasushi; Hitotsuyanagi Yukio; Takeya Koichi; Sato Yasufumi
Metronomic scheduling of a cyclic hexapeptide Ra-VII for anti-angiogenesis, tumor vessel maturation and anti-tumor activity.
Cancer science 2006;97(7):665-74.
2006: Saito Masaki; Hori Megumi; Obara Yutaro; Ohizumi Yasushi; Ohkubo Satoko; Nakahata Norimichi
Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;28(4):263-71.
2006: Kitazawa Masashi; Shibata Yasutaka; Hashimoto Seiichi; Ohizumi Yasushi; Yamakuni Tohru
Proinsulin C-peptide stimulates a PKC/IkappaB/NF-kappaB signaling pathway to activate COX-2 gene transcription in Swiss 3T3 fibroblasts.
Journal of biochemistry 2006;139(6):1083-8.
2006: Toriniwa Yasufumi; Lv Xiaochuan; Kodama Yasuo; Ohizumi Yasushi; Yoshida Makoto; Nakahata Norimichi
Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis.
The Journal of pharmacy and pharmacology 2006;58(6):859-66.
2006: Matsuzaki Kentaro; Yamakuni Tohru; Hashimoto Michio; Haque Abdul Md; Shido Osamu; Mimaki Yoshihiro; Sashida Yutaka; Ohizumi Yasushi
Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats.
Neuroscience letters 2006;400(3):230-4.
2006: Ono Yuka; Hattori Eri; Fukaya Yukitaka; Imai Shoji; Ohizumi Yasushi
Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats.
Journal of ethnopharmacology 2006;106(2):238-44.
2006: Kakizaki Atsushi; Takahashi Masami; Akagi Hiroyuki; Tachikawa Eiichi; Yamamoto Toshifumi; Taira Eiichi; Yamakuni Tohru; Ohizumi Yasushi
Ca2+ channel activating action of maitotoxin in cultured brainstem neurons.
European journal of pharmacology 2006;536(3):223-31.
2006: Guo Yuanqiang; Xu Jing; Li Yushan; Yamakuni Tohru; Ohizumi Yasushi
Three-membered ring sesquiterpenoids with NGF-potentiating activity from the roots of Valeriana fauriei.
Planta medica 2006;72(4):373-5.
2006: Guo Yuanqiang; Li Yushan; Xu Jing; Watanabe Ryuichi; Oshima Yasukatsu; Yamakuni Tohru; Ohizumi Yasushi
Bioactive ent-clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana.
Journal of natural products 2006;69(2):274-6.
2006: Yamakuni Tohru; Aoki Koichi; Nakatani Keigo; Kondo Nobuhiko; Oku Hisae; Ishiguro Kyoko; Ohizumi Yasushi
Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells.
Neuroscience letters 2006;394(3):206-10.
2006: Guo Yuanqiang; Xu Jing; Li Yushan; Watanabe Ryuichi; Oshima Yasukatsu; Yamakuni Tohru; Ohizumi Yasushi
Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei.
Chemical & pharmaceutical bulletin 2006;54(1):123-5.
2005: Nagase Hiroyuki; Omae Naoki; Omori Akiko; Nakagawasai Osamu; Tadano Takeshi; Yokosuka Akihito; Sashida Yutaka; Mimaki Yoshihiro; Yamakuni Tohru; Ohizumi Yasushi
Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities.
Biochemical and biophysical research communications 2005;337(4):1330-6.
2005: Rohra Dileep Kumar; Saito Shin-ya; Ohizumi Yasushi
Low extracellular Cl- environment attenuates changes in intracellular pH and contraction following extracellular acidosis in Wistar Kyoto rat aorta.
Pharmacology 2005;75(1):30-6.
2005: Nagase Hiroyuki; Yamakuni Tohru; Matsuzaki Kentaro; Maruyama Yuji; Kasahara Jiro; Hinohara Yoshimi; Kondo Shunzo; Mimaki Yoshihiro; Sashida Yutaka; Tank A William; Fukunaga Kohji; Ohizumi Yasushi
Mechanism of neurotrophic action of nobiletin in PC12D cells.
Biochemistry 2005;44(42):13683-91.
2005: Onodera Ken-Ichi; Nakamura Hideshi; Oba Yuichi; Ohizumi Yasushi; Ojika Makoto
Zooxanthellamide Cs: vasoconstrictive polyhydroxylated macrolides with the largest lactone ring size from a marine dinoflagellate of Symbiodinium sp.
Journal of the American Chemical Society 2005;127(29):10406-11.
2005: Aoki Kohichi; Yamakuni Tohru; Yoshida Masaaki; Ohizumi Yasushi
Ephedorae herba decreases lipopolysaccharide-induced cyclooxgenase-2 protein expression and NF-kappaB-dependent transcription in C6 rat glioma cells.
Journal of pharmacological sciences 2005;98(3):327-30.
2005: Kitazawa Masashi; Yamakuni Tohru; Song Si-Young; Kato Chieko; Tsuchiya Reiko; Ishida Mami; Suzuki Nobuhide; Adachi Eijiro; Iwashita Shintaro; Ueno Susumu; Yanagihara Nobuyuki; Taoka Masato; Isobe Toshiaki; Ohizumi Yasushi
Intracellular cAMP controls a physical association of V-1 with CapZ in cultured mammalian endocrine cells.
Biochemical and biophysical research communications 2005;331(1):181-6.
2005: Tsuda Masashi; Yamakawa Masaaki; Oka Seiko; Tanaka Yasushi; Hoshino Yasutake; Mikami Yuzuru; Sato Ayumi; Fujiwara Hironori; Ohizumi Yasushi; Kobayashi Jun'ichi
Brasilibactin A, a cytotoxic compound from actinomycete Nocardia brasiliensis.
Journal of natural products 2005;68(3):462-4.
2005: Horai Yasushi; Furukawa Ken-Ichi; Iwata Shingo; Ohizumi Yasushi
Changes in pH increase perfusion pressure of coronary arteries in the rat.
Journal of pharmacological sciences 2005;97(3):400-7.
2004: Rohra Dileep Kumar; Yamakuni Tohru; Ohizumi Yasushi
Acidosis-induced protein tyrosine phosphorylation depends on Ca2+ influx via voltage-dependent Ca2+ channels in SHR aorta.
European journal of pharmacology 2004;504(1-2):105-11.
2004: Nakatani Keigo; Yamakuni Tohru; Kondo Nobuhiko; Arakawa Tsutomu; Oosawa Kenji; Shimura Susumu; Inoue Hiroyasu; Ohizumi Yasushi
gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.
Molecular pharmacology 2004;66(3):667-74.
2004: Fujiwara Hironori; Yamakuni Tohru; Ueno Mitsuhiro; Ishizuka Masaaki; Shinkawa Takashi; Isobe Toshiaki; Ohizumi Yasushi
IC101 induces apoptosis by Akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with Akt in L1210 cells.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1288-95.
2004: Saito Shin-Ya; Tanaka Masashi; Matsunaga Kimihiro; Li Yushan; Ohizumi Yasushi
The combination of rat mast cell and rabbit aortic smooth muscle is the simple bioassay for the screening of anti-allergic ingredient from methanolic extract of Corydalis tuber.
Biological & pharmaceutical bulletin 2004;27(8):1270-4.
2004: Saito Shin-ya; Kamiyama Sachie; Oda Mayumi; Nakahata Norimichi; Ohizumi Yasushi
Inhibitory effect of Mao-Bushi-Saishin-to on prostaglandin E2 synthesis in C6 rat glioma cells.
Biological & pharmaceutical bulletin 2004;27(7):1133-5.
2004: Saito Shin-ya; Feng Jue; Kira Atsushi; Kobayashi Jun'ichi; Ohizumi Yasushi
Amphidinolide H, a novel type of actin-stabilizing agent isolated from dinoflagellate.
Biochemical and biophysical research communications 2004;320(3):961-5.
2004: Li Yushan; Ohizumi Yasushi
Search for constituents with neurotrophic factor-potentiating activity from the medicinal plants of paraguay and Thailand.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2004;124(7):417-24.
2004: Fujiwara Hironori; Saito Shin-ya; Hitotsuyanagi Yukio; Takeya Koichi; Ohizumi Yasushi
RA-VII, a cyclic depsipeptide, changes the conformational structure of actin to cause G2 arrest by the inhibition of cytokinesis.
Cancer letters 2004;209(2):223-9.
2004: Saito Shin-ya; Maruyama Yukiko; Kamiyama Sachie; Nakahata Norimichi; Ohizumi Yasushi
Ephedrae herba in Mao-Bushi-Saishin-To inhibits IgE-mediated histamine release and increases cAMP content in RBL-2H3 cells.
Journal of pharmacological sciences 2004;95(1):41-6.
2004: Sato Ayumi; Fujiwara Hironori; Oku Hisae; Ishiguro Kyoko; Ohizumi Yasushi
Alpha-mangostin induces Ca2+-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells.
Journal of pharmacological sciences 2004;95(1):33-40.
2004: Taniguchi Satoshi; Furukawa Ken-Ichi; Sasamura Satoshi; Ohizumi Yasushi; Seya Kazuhiko; Motomura Shigeru
Gene expression and functional activity of sodium/calcium exchanger enhanced in vascular smooth muscle cells of spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 2004;43(5):629-37.
2004: Rohra Dileep Kumar; Yamakuni Tohru; Ito Saiko; Saito Shin-Ya; Ohizumi Yasushi
Evidence for the involvement of protein kinase C in acidic pH-induced contraction in spontaneously hypertensive rat aorta.
Pharmacology 2004;71(1):10-6.
2004: Li Yushan; Chen Xigui; Satake Masayuki; Oshima Yasukatsu; Ohizumi Yasushi
Acetylated flavonoid glycosides potentiating NGF action from Scoparia dulcis.
Journal of natural products 2004;67(4):725-7.
2003: Rohra D K; Saito S-Y; Ohizumi Y
Mechanism of acidic pH-induced contraction in spontaneously hypertensive rat aorta: role of Ca2+ release from the sarcoplasmic reticulum.
Acta physiologica Scandinavica 2003;179(3):273-80.
2003: Li Ping; Matsunaga Kimihiro; Yamakuni Tohru; Ohizumi Yasushi
Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells.
Brain research. Developmental brain research 2003;145(2):177-83.
2003: Chanmahasathien Wisinee; Li Yushan; Satake Masayuki; Oshima Yasukatsu; Ishibashi Masami; Ruangrungsi Nijsiri; Ohizumi Yasushi
Prenylated xanthones from Garcinia xanthochymus.
Chemical & pharmaceutical bulletin 2003;51(11):1332-4.
2003: Chanmahasathien Wisinee; Li Yushan; Satake Masayuki; Oshima Yasukatsu; Ruangrungsi Nijsiri; Ohizumi Yasushi
Prenylated xanthones with NGF-potentiating activity from Garcinia xanthochymus.
Phytochemistry 2003;64(5):981-6.
2003: Tsuchida Hisatoshi; Ohizumi Yasushi
(+)-Nantenine isolated from Nandina domestica Thunb. inhibits adrenergic pressor responses in pithed rats.
European journal of pharmacology 2003;477(1):53-8.
2003: Li Ping; Yamakuni Tohru; Matsunaga Kimihiro; Kondo Shunzo; Ohizumi Yasushi
Nardosinone enhances nerve growth factor-induced neurite outgrowth in a mitogen-activated protein kinase- and protein kinase C-dependent manner in PC12D cells.
Journal of pharmacological sciences 2003;93(1):122-5.
2003: Li Yushan; Ishibashi Masami; Satake Masayuki; Oshima Yasukatsu; Ohizumi Yasushi
A new iridoid glycoside with nerve growth factor-potentiating activity, gelsemiol 6'-trans-caffeoyl-1-glucoside, from Verbena littoralis.
Chemical & pharmaceutical bulletin 2003;51(9):1103-5.
2003: Kodama Yasuo; Xiaochuan Lv; Tsuchiya Chikako; Ohizumi Yasushi; Yoshida Makoto; Nakahata Norimichi
Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells.
Planta medica 2003;69(8):765-7.
2003: Rohra Dileep Kumar; Saito Shin-ya; Ohizumi Yasushi
Strain-specific effects of acidic pH on contractile state of aortas from Wistar and Wistar Kyoto rats.
European journal of pharmacology 2003;476(1-2):123-30.
2003: Li Yushan; Ishibashi Masami; Chen Xigui; Ohizumi Yasushi
Littorachalcone, a new enhancer of NGF-mediated neurite outgrowth, from Verbena littoralis.
Chemical & pharmaceutical bulletin 2003;51(7):872-4.
2003: Li Yushan; Ishibashi Masami; Satake Masayuki; Chen Xigui; Oshima Yasukatsu; Ohizumi Yasushi
Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity.
Journal of natural products 2003;66(5):696-8.
2003: Hirata Yutaka; Atsumi Masanori; Ohizumi Yasushi; Nakahata Norimichi
Mastoparan binds to glycogen phosphorylase to regulate sarcoplasmic reticular Ca2+ release in skeletal muscle.
The Biochemical journal 2003;371(Pt 1):81-8.
2003: Rohra Dileep Kumar; Saito Shin-ya; Ohizumi Yasushi
Extracellular acidosis results in higher intracellular acidosis and greater contraction in spontaneously hypertensive rat aorta.
European journal of pharmacology 2003;465(1-2):141-4.
2003: Nakahata Norimichi; Tsuchiya Chikako; Nakatani Keigo; Ohizumi Yasushi; Ohkubo Satoko
Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells.
European journal of pharmacology 2003;461(1):1-7.
2003: Rohra Dileep Kumar; Saito Shin-ya; Ohizumi Yasushi
Functional role of ryanodine-sensitive Ca2+ stores in acidic pH-induced contraction in Wistar Kyoto rat aorta.
Life sciences 2003;72(11):1259-69.
2002: Rohra Dileep Kumar; Yamakuni Tohru; Furukawa Ken-Ichi; Ishii Noe; Shinkawa Takashi; Isobe Toshiaki; Ohizumi Yasushi
Stimulated tyrosine phosphorylation of phosphatidylinositol 3-kinase causes acidic pH-induced contraction in spontaneously hypertensive rat aorta.
The Journal of pharmacology and experimental therapeutics 2002;303(3):1255-64.
2002: Mitsui-Saito Minori; Ohkubo Satoko; Obara Yutaro; Yanagisawa Teruyuki; Kobayashi Jun'Ichi; Ohizumi Yasushi; Nakahata Norimichi
Theonezolide A, a novel marine macrolide, induces drastic shape change in rabbit platelets by reorganization of microtubules.
Thrombosis research 2002;108(2-3):133-8.
2002: Yamakuni Tohru; Suzuki Takahiro; Inagaki Hideo; Ohizumi Yasushi; Nagatsu Toshiharu; Ichinose Hiroshi
[V-1, a catecholamine biosynthesis regulatory protein, enhances GTP cyclohydrolase I gene transcription in a cAMP-responsive element dependent manner]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(1):82P-84P.
2002: Yamakuni Tohru; Hashimoto Michio; Sakagami Hiroyuki; Yamamoto Toshifumi; Kobayashi Masumi; Fujii Yoshimi; Yamamoto Hideko; Rohra Dileep Kumar; Hiwatashi Yusuke; Honma Takao; Kondo Hisatake; Shido Osamu; Ohizumi Yasushi
Expression of V-1, a novel catecholamine biosynthesis regulatory protein, is enhanced by hypertension in atrial myocytes of Dahl salt-sensitive rats.
Biochemical and biophysical research communications 2002;298(5):793-7.
2002: Sasamura Satoshi; Furukawa Ken-Ichi; Shiratori Miwa; Motomura Shigeru; Ohizumi Yasushi
Antisense-inhibition of plasma membrane Ca2+ pump induces apoptosis in vascular smooth muscle cells.
Japanese journal of pharmacology 2002;90(2):164-72.
2002: Rohra Dileep Kumar; Saito Shin-ya; Ohizumi Yasushi
Functional role of Cl- channels in acidic pH-induced contraction of the aorta of spontaneously hypertensive and Wistar Kyoto rats.
European journal of pharmacology 2002;453(2-3):279-86.
2002: Yamakuni Tohru; Yamamoto Toshifumi; Ishida Yukisato; Yamamoto Hideko; Song Si Young; Adachi Eijiro; Hiwatashi Yusuke; Ohizumi Yasushi
V-1, a catecholamine biosynthesis regulatory protein, positively controls catecholamine secretion in PC12D cells.
FEBS letters 2002;530(1-3):94-8.
2002: Hiwatashi Yusuke; Kurahashi Yusuke; Hatada Risa; Ueno Susumu; Honma Takao; Yanagihara Nobuyuki; Yanase Haruko; Iwanaga Toshihiko; Ohizumi Yasushi; Yamakuni Tohru
Glucocorticoid inhibits expression of V-1, a catecholamine biosynthesis regulatory protein, in cultured adrenal medullary cells.
FEBS letters 2002;528(1-3):166-70.
2002: Nakatani Keigo; Atsumi Masanori; Arakawa Tsutomu; Oosawa Kenji; Shimura Susumu; Nakahata Norimichi; Ohizumi Yasushi
Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant.
Biological & pharmaceutical bulletin 2002;25(9):1137-41.
2002: Li Ping; Matsunaga Kimihiro; Yamakuni Tohru; Ohizumi Yasushi
Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells.
Life sciences 2002;71(15):1821-35.
2002: Indra Bachtiar; Matsunaga Kimihiro; Hoshino Osamu; Suzuki Masaji; Ogasawara Hiromichi; Muramatsu Ikunobu; Taniguchi Takanobu; Ohizumi Yasushi
(+/-)-Domesticine, a novel and selective alpha1D-adrenoceptor antagonist in animal tissues and human alpha 1-adrenoceptors.
European journal of pharmacology 2002;445(1-2):21-9.
2002: Obara Yutaro; Aoki Takashi; Kusano Masayoshi; Ohizumi Yasushi
Beta-eudesmol induces neurite outgrowth in rat pheochromocytoma cells accompanied by an activation of mitogen-activated protein kinase.
The Journal of pharmacology and experimental therapeutics 2002;301(3):803-11.
2002: Indra Bachtiar; Tadano Takeshi; Nakagawasai Osamu; Arai Yuichiro; Yasuhara Hajime; Ohizumi Yasushi; Kisara Kensuke
Suppressive effect of nantenine, isolated from Nandina domestica Thunberg, on the 5-hydroxy-L-tryptophan plus clorgyline-induced head-twitch response in mice.
Life sciences 2002;70(22):2647-56.
2002: Indra Bachtiar; Matsunaga Kimihiro; Hoshino Osamu; Suzuki Masaji; Ogasawara Hiromichi; Ishiguro Masaji; Ohizumi Yasushi
Structure-activity relationship on (+/-)-nantenine derivatives in antiserotonergic activities in rat aorta.
Canadian journal of physiology and pharmacology 2002;80(3):198-204.
2002: Indra Bachtiar; Matsunaga Kimihiro; Hoshino Osamu; Suzuki Masaji; Ogasawara Hiromichi; Ohizumi Yasushi
Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity.
European journal of pharmacology 2002;437(3):173-8.
2002: Candra E; Matsunaga K; Fujiwara H; Mimaki Y; Kuroda M; Sashida Y; Ohizumi Y
Potent apoptotic effects of saponins from Liliaceae plants in L1210 cells.
The Journal of pharmacy and pharmacology 2002;54(2):257-62.
2002: Abe Mayumi; Inoue Daisuke; Matsunaga Kimihiro; Ohizumi Yasushi; Ueda Hiroshi; Asano Tomiko; Murakami Masahiro; Sato Yasufumi
Goniodomin A, an antifungal polyether macrolide, exhibits antiangiogenic activities via inhibition of actin reorganization in endothelial cells.
Journal of cellular physiology 2002;190(1):109-16.
2002: Nakatani Keigo; Nakahata Norimichi; Arakawa Tsutomu; Yasuda Hideyuki; Ohizumi Yasushi
Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells.
Biochemical pharmacology 2002;63(1):73-9.
2001: Moriya T; Furukawa K; Nakamura H; Murai A; Ohizumi Y
The vaso-contractile action of zooxanthellatoxin-B from a marine dinoflagellate is mediated via Ca2+ influx in the rabbit aorta.
Canadian journal of physiology and pharmacology 2001;79(12):1030-5.
2001: Nakatani K; Nakahata N; Tsurufuji S; Ohizumi Y
Preconditioning of 3T3 cells by fresh medium together with genistein enhances prostaglandin E(2) release.
European journal of pharmacology 2001;432(2-3):135-42.
2001: Candra E; Matsunaga K; Fujiwara H; Mimaki Y; Sashida Y; Yamakuni T; Ohizumi Y
Two steroidal saponins from Camassia cusickii induce L1210 cell death through the apoptotic mechanism.
Canadian journal of physiology and pharmacology 2001;79(11):953-8.
2001: Iwata S; Saito S; Kon-ya K; Shizuri Y; Ohizumi Y
Novel marine-derived halogen-containing gramine analogues induce vasorelaxation in isolated rat aorta.
European journal of pharmacology 2001;432(1):63-70.
2001: Pengsuparp T; Indra B; Nakagawasai O; Tadano T; Mimaki Y; Sashida Y; Ohizumi Y; Kisara K
Pharmacological studies of geissoschizine methyl ether, isolated from Uncaria sinensis Oliv., in the central nervous system.
European journal of pharmacology 2001;425(3):211-8.
2001: Li Y S; Matsunaga K; Kato R; Ohizumi Y
Potentiation of nerve growth factor-induced elongation of neurites by gelsemiol and 9-hydroxysemperoside aglucone in PC12D cells.
The Journal of pharmacy and pharmacology 2001;53(6):915-9.
2001: Li Y S; Matsunaga K; Kato R; Ohizumi Y
Verbenachalcone, a novel dimeric dihydrochalcone with potentiating activity on nerve growth factor-action from Verbena littoralis.
Journal of natural products 2001;64(6):806-8.
2001: Obara Y; Kobayashi H; Ohta T; Ohizumi Y; Nakahata N
Scabronine G-methylester enhances secretion of neurotrophic factors mediated by an activation of protein kinase C-zeta.
Molecular pharmacology 2001;59(5):1287-97.
2001: Ohi Y; Atsuki K; Tori Y; Ohizumi Y; Watanabe M; Imaizumi Y
Imaging of Ca2+ release by caffeine and 9-methyl-7-bromoeudistomin D and the associated activation of large conductance Ca2+-dependent K+ channels in urinary bladder smooth muscle cells of the guinea pig.
Japanese journal of pharmacology 2001;85(4):382-90.
2001: Li Y S; Matsunaga K; Ishibashi M; Ohizumi Y
Littoralisone, a novel neuritogenic iridolactone having an unprecedented heptacyclic skeleton including four- and nine-membered rings consisting of glucose from Verbena littoralis.
The Journal of organic chemistry 2001;66(6):2165-7.
2001: Fujiwara H; Matsunaga K; Saito M; Hagiya S; Furukawa K; Nakamura H; Ohizumi Y
Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells.
European journal of pharmacology 2001;413(1):37-45.
2000: Li P; Matsunaga K; Yamakuni T; Ohizumi Y
Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells.
European journal of pharmacology 2000;406(2):203-8.
2000: Obara Y; Nakahata N; Mizushina Y; Sugawara F; Sakaguchi K; Ohizumi Y
Differentiation of rat pheochromocytoma cells by fomitellic acids, specific DNA polymerase inhibitors.
Life sciences 2000;67(13):1659-65.
2000: Li P; Matsunaga K; Ohizumi Y
Nerve growth factor-potentiating compounds from Picrorhizae Rhizoma.
Biological & pharmaceutical bulletin 2000;23(7):890-2.
2000: Hirata Y; Nakahata N; Ohizumi Y
Identification of a 97-kDa mastoparan-binding protein involving in Ca(2+) release from skeletal muscle sarcoplasmic reticulum.
Molecular pharmacology 2000;57(6):1235-42.
2000: Seino-Umeda A; Ishibashi M; Kobayashi J; Ohizumi Y
Structure-activity relationships for the Ca2+-releasing activity of 6-hydroxy-beta-carboline analogues in skeletal muscle sarcoplasmic reticulum-the effects of halogen substitution at C-5 and C-7.
The Journal of pharmacy and pharmacology 2000;52(5):517-21.
2000: Kobayashi H; Honma S; Nakahata N; Ohizumi Y
Involvement of phosphatidylcholine-specific phospholipase C in thromboxane A2-induced activation of mitogen-activated protein kinase in astrocytoma cells.
Journal of neurochemistry 2000;74(5):2167-73.
2000: Mitsui-Saito M; Nakahata N; Ohizumi Y
Inhibition of microtubule polymerization by SK&F 96365, a blocker of receptor-linked Ca2+ entry.
Japanese journal of pharmacology 2000;82(3):269-71.
2000: Nakahata N; Takano H; Ohizumi Y
Thromboxane A2 receptor-mediated tonic contraction is attributed to an activation of phosphatidylcholine-specific phospholipase C in rabbit aortic smooth muscles.
Life sciences 2000;66(5):PL 71-6.
1999: Kyo R; Nakahata N; Kodama Y; Nakai Y; Kubo M; Ohizumi Y
Antagonism of saikosaponin-induced prostaglandin E2 release by baicalein in C6 rat glioma cells.
Biological & pharmaceutical bulletin 1999;22(12):1385-7.
1999: Matsunaga K; Nakatani K; Murakami M; Yamaguchi K; Ohizumi Y
Powerful activation of skeletal muscle actomyosin ATPase by goniodomin A is highly sensitive to troponin/tropomyosin complex.
The Journal of pharmacology and experimental therapeutics 1999;291(3):1121-6.
1999: Ito M; Hirata Y; Nakamura H; Ohizumi Y
Xestoquinone, isolated from sea sponge, causes Ca(2+) release through sulfhydryl modification from skeletal muscle sarcoplasmic reticulum.
The Journal of pharmacology and experimental therapeutics 1999;291(3):976-81.
1999: Nakatani K; Murayama T; Satoh Y; Furukawa K I; Omura S; Ohizumi Y
Modulation of actomyosin ATPase by thiotetromycin is mediated through conformational change of actin.
European journal of pharmacology 1999;383(3):381-6.
1999: Matsunaga K; Nakatani K; Murakami M; Nakahata N; Ohizumi Y
[Goniodomin A induces modulation of actomyosin ATPase activity mediated through conformational change of actin]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():220P-224P.
1999: Nakahata N; Kyo R; Kutsuwa M; Ohizumi Y
[Inhibition of mitogen-activated protein kinase cascade by baicalein, a flavonoid of natural origin]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():215P-219P.
1999: Nakahata N; Yaginuma T; Ohizumi Y
Maitotoxin-induced phosphoinositide hydrolysis is dependent on extracellular but not intracellular Ca2+ in human astrocytoma cells.
Japanese journal of pharmacology 1999;81(2):240-3.
1999: Hirata Y; Ito M; Nikai T; Kato S; Komori Y; Sugiura H; Ohizumi Y
Himehabu lectin, a novel inducer of Ca2+-release from the venom of the snake Trimeresurus okinavensis, in sarcoplasmic reticulum.
The Journal of pharmacy and pharmacology 1999;51(10):1207-11.
1999: Nakahata N; Harada Y; Tsuji M; Kon-ya K; Shizuri Y; Ohizumi Y
Structure-activity relationship of gramine derivatives in Ca(2+) release from sarcoplasmic reticulum.
European journal of pharmacology 1999;382(2):129-32.
1999: Nakahata N; Ohkubo S; Ito E; Nakano M; Terao K; Ohizumi Y
Comparison of maitotoxin with thromboxane A2 in rabbit platelet activation.
Toxicon : official journal of the International Society on Toxinology 1999;37(10):1375-89.
1999: Li P; Matsunaga K; Yamamoto K; Yoshikawa R; Kawashima K; Ohizumi Y
Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells.
Neuroscience letters 1999;273(1):53-6.
1999: Honma S; Nakahata N; Kobayashi H; Ikeda S; Takeda N; Ohizumi Y
Decrease in thromboxane A2 receptor expression by differentiation with dibutyryl cyclic AMP in 1321N1 human astrocytoma cells.
Prostaglandins & other lipid mediators 1999;58(1):51-62.
1999: Obara Y; Takahashi M; Nakahata N; Ohizumi Y
Maitotoxin-induced nerve growth factor production accompanied by the activation of a voltage-insensitive Ca2+ channel in C6-BU-1 glioma cells.
British journal of pharmacology 1999;127(7):1577-82.
1999: Hirata Y; Nakahata N; Ohkura M; Ohizumi Y
Identification of 30 kDa protein for Ca(2+) releasing action of myotoxin a with a mechanism common to DIDS in skeletal muscle sarcoplasmic reticulum.
Biochimica et biophysica acta 1999;1451(1):132-40.
1999: Li P; Matsunaga K; Ohizumi Y
Enhancement of the nerve growth factor-mediated neurite outgrowth from PC12D cells by Chinese and Paraguayan medicinal plants.
Biological & pharmaceutical bulletin 1999;22(7):752-5.
1999: Nakahata N; Takano H; Ohizumi Y
Thromboxane A2-induced phosphatidylcholine hydrolysis in porcine vascular smooth muscle cells.
European journal of pharmacology 1999;374(1):157-60.
1999: Suzuki A; Matsunaga K; Mimaki Y; Sashida Y; Ohizumi Y
Properties of amentoflavone, a potent caffeine-like Ca2+ releaser in skeletal muscle sarcoplasmic reticulum.
European journal of pharmacology 1999;372(1):97-102.
1999: Ohizumi Y; Hirata Y; Suzuki A; Kobayashi M
Two novel types of calcium release from skeletal sarcoplasmic reticulum by phosphatidylinositol 4,5-biphosphate.
Canadian journal of physiology and pharmacology 1999;77(4):276-85.
1999: Obara Y; Nakahata N; Kita T; Takaya Y; Kobayashi H; Hosoi S; Kiuchi F; Ohta T; Oshima Y; Ohizumi Y
Stimulation of neurotrophic factor secretion from 1321N1 human astrocytoma cells by novel diterpenoids, scabronines A and G.
European journal of pharmacology 1999;370(1):79-84.
1999: Kuniyasu A; Kawano S; Hirayama Y; Ji Y H; Xu K; Ohkura M; Furukawa K; Ohizumi Y; Hiraoka M; Nakayama H
A new scorpion toxin (BmK-PL) stimulates Ca2+-release channel activity of the skeletal-muscle ryanodine receptor by an indirect mechanism.
The Biochemical journal 1999;339 ( Pt 2)():343-50.
1999: Matsunaga K; Nakatani K; Ishibashi M; Kobayashi J; Ohizumi Y
Amphidinolide B, a powerful activator of actomyosin ATPase enhances skeletal muscle contraction.
Biochimica et biophysica acta 1999;1427(1):24-32.
1998: Nakahata N; Honma S; Kobayashi H; Ohizumi Y
[Thromboxane A2 receptor-mediated signal transduction in glial cells]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1998;112 Suppl 1():113P-117P.
1998: Tsukii K; Nakahata N; Tsurufuji S; Ohizumi Y
Ca2+-independent synergistic augmentation of O2- production by FMLP and PMA in HL-60 cells.
Canadian journal of physiology and pharmacology 1998;76(10-11):1024-32.
1998: Kyo R; Nakahata N; Sakakibara I; Kubo M; Ohizumi Y
Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on intracellular Ca2+ mobilization in C6 rat glioma cells.
Biological & pharmaceutical bulletin 1998;21(10):1067-71.
1998: Kyo R; Nakahata N; Sakakibara I; Kubo M; Ohizumi Y
Baicalin and baicalein, constituents of an important medicinal plant, inhibit intracellular Ca2+ elevation by reducing phospholipase C activity in C6 rat glioma cells.
The Journal of pharmacy and pharmacology 1998;50(10):1179-82.
1998: Ohkura M; Furukawa K; Fujimori H; Kuruma A; Kawano S; Hiraoka M; Kuniyasu A; Nakayama H; Ohizumi Y
Dual regulation of the skeletal muscle ryanodine receptor by triadin and calsequestrin.
Biochemistry 1998;37(37):12987-93.
1998: Nakatani K; Nakahata N; Hamada Y; Tsurufuji S; Ohizumi Y
Medium change amplifies mitogen-activated protein kinase-mediated prostaglandin E2 synthesis in Swiss 3T3 fibroblasts.
European journal of pharmacology 1998;356(1):91-100.
1998: Mizuno K; Nakahata N; Ito E; Murakami M; Yamaguchi K; Ohizumi Y
Goniodomin A, an antifungal polyether macrolide, increases the filamentous actin content of 1321N1 human astrocytoma cells.
The Journal of pharmacy and pharmacology 1998;50(6):645-8.
1998: Moriya T; Ishida Y; Nakamura H; Asari T; Murai A; Ohizumi Y
Vasoconstriction induced by zooxanthellatoxin-B, a polyoxygenated long-chain product from a marine alga.
European journal of pharmacology 1998;350(1):59-65.
1998: Ohizumi Y; Matsunaga K; Nakatani K; Kobayashi J
Potent stimulation of myofilament force and ATPase activity of skeletal muscle by eudistomin M, a novel Ca(++)-sensitizing agent from a Caribbean tunicate.
The Journal of pharmacology and experimental therapeutics 1998;285(2):695-9.
1998: Katagiri C; Ishikawa H H; Ohkura M; Nakagawasai O; Tadano T; Kisara K; Ohizumi Y
Properties of specific binding site of myotoxin a, a powerful convulsant, in brain microsomes.
Canadian journal of physiology and pharmacology 1998;76(4):395-400.
1998: Mizuno K; Nakahata N; Ohizumi Y
Characterization of mastoparan-induced histamine release from RBL-2H3 cells.
Toxicon : official journal of the International Society on Toxinology 1998;36(3):447-56.
1998: Rho M C; Nakahata N; Ohizumi Y
Two distinct effects of 12S-hydroxyeicosatetraenoic acid on platelet aggregation by zooxanthellatoxin-A and ionomycin.
Japanese journal of pharmacology 1998;76(1):117-20.
1998: Ohizumi Y; Matsunaga K; Nakatani K; Kobayashi J
The powerful stimulatory action of 6-O-acetyl-9-methyl-7-bromoeudistomin D on the contractile protein system of rabbit skeletal muscle.
Japanese journal of pharmacology 1998;76(1):113-6.
1998: Chairungsrilerd N; Furukawa K I; Ohta T; Nozoe S; Ohizumi Y
Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(1):25-31.
1998: Nakahata N; Kutsuwa M; Kyo R; Kubo M; Hayashi K; Ohizumi Y
Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells.
The American journal of Chinese medicine 1998;26(3-4):311-23.
1997: Fang Y I; Yokota E; Mabuchi I; Nakamura H; Ohizumi Y
Purealin blocks the sliding movement of sea urchin flagellar axonemes by selective inhibition of half the ATPase activity of axonemal dyneins.
Biochemistry 1997;36(50):15561-7.
1997: Furukawa K I; Matsuzawa M; Tsurufuji S; Watanabe K; Ohizumi Y
The mechanism of rabbit platelet aggregation induced by 2,5-di-(tert-butyl)-1,4-benzohydroquinone, an inhibitor of endoplasmic reticulum Ca2+-ATPase.
Japanese journal of pharmacology 1997;75(3):295-8.
1997: Nakahata N; Rho M; Ohizumi Y
[Effect of zooxanthellatoxin-A, an unique marine product, on arachidonic acid cascade in rabbit platelets]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1997;110 Suppl 1():189P-194P.
1997: Furukawa K; Chairungsrilerd N; Ohta T; Nozoe S; Ohizumi Y
[Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1997;110 Suppl 1():153P-158P.
1997: Rho M C; Nakahata N; Nakamura H; Murai A; Ohizumi Y
Involvement of phospholipase C-gamma2 in activation of mitogen-activated protein kinase and phospholipase A2 by zooxanthellatoxin-A in rabbit platelets.
The Journal of pharmacology and experimental therapeutics 1997;282(1):496-504.
1997: Ohizumi Y
Application of physiologically active substances isolated from natural resources to pharmacological studies.
Japanese journal of pharmacology 1997;73(4):263-89.
1997: Rho M C; Nakahata N; Nakamura H; Murai A; Ohizumi Y
Tyrphostin 23 blocks phosphorylation of p42 but not p38 mitogen-activated protein kinase by zooxanthellatoxin-A.
European journal of pharmacology 1997;319(2-3):375-8.
1996: Rho M C; Matsunaga K; Park Y H; Yasuda K; Yamasu T; Mayama S; Ohizumi Y
A sulfonoglycolipid with Na+,K+-ATPase inhibitory activity, produced by a cultured unique diatom symbiont isolated from a larger foraminifera.
Planta medica 1996;62(6):552-4.
1996: Ohkubo S; Nakahata N; Ohizumi Y
Thromboxane A2 stimulates mitogen-activated protein kinase and arachidonic acid liberation in rabbit platelets.
Prostaglandins 1996;52(5):403-13.
1996: Chairungsrilerd N; Furukawa K; Ohta T; Nozoe S; Ohizumi Y
Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist.
European journal of pharmacology 1996;314(3):351-6.
1996: Chairungsrilerd N; Furukawa K; Ohta T; Nozoe S; Ohizumi Y
Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana.
Planta medica 1996;62(5):471-2.
1996: Ohizumi Y; Sasaki S; Shibusawa K; Ishikawa K; Ikemoto F
Stimulation of sarcoplasmic reticulum Ca(2+)-ATPase by gingerol analogues.
Biological & pharmaceutical bulletin 1996;19(10):1377-9.
1996: Furukawa K; Shibusawa K; Chairungsrilerd N; Ohta T; Nozoe S; Ohizumi Y
The mode of inhibitory action of alpha-mangostin, a novel inhibitor, on the sarcoplasmic reticulum Ca(2+)-pumping ATPase from rabbit skeletal muscle.
Japanese journal of pharmacology 1996;71(4):337-40.
1996: Ohizumi Y; Sasaki S; Kusumi T; Ohtani I I
Ptilomycalin A, a novel Na+, K(+)- or Ca2(+)-ATPase inhibitor, competitively interacts with ATP at its binding site.
European journal of pharmacology 1996;310(1):95-8.
1996: Furukawa K; Komaba J; Sakai H; Ohizumi Y
The mechanism of acidic pH-induced contraction in aortae from SHR and WKY rats enhanced by increasing blood pressure.
British journal of pharmacology 1996;118(3):485-92.
1996: Ohkura M; Miyashita Y; Kakubari M; Hayakawa Y; Seto H; Ohizumi Y
Characteristics of 45Ca2+ release induced by quinolidomicin A1, a 60-membered macrolide from skeletal muscle sarcoplasmic reticulum.
Biochimica et biophysica acta 1996;1294(2):177-82.
1996: Ohkura M; Miyashita Y; Nikai T; Suzuki J; Komori Y; Sugihara H; Ohizumi Y
Properties of Ca++ release induced by puff adder lectin, a novel lectin from the snake Bitis arietans, in sarcoplasmic reticulum.
The Journal of pharmacology and experimental therapeutics 1996;277(2):1043-8.
1996: Ohkubo S; Nakahata N; Ohizumi Y
Thromboxane A2-mediated shape change: independent of Gq-phospholipase C--Ca2+ pathway in rabbit platelets.
British journal of pharmacology 1996;117(6):1095-104.
1996: Rho M C; Matsunaga K; Yasuda K; Ohizumi Y
A novel monogalactosylacylglycerol with inhibitory effect on platelet aggregation from the cyanophyceae Oscillatoria rosea.
Journal of natural products 1996;59(3):308-9.
1996: Ohkubo S; Nakahata N; Ohizumi Y
ML-7 and W-7 facilitate thromboxane A2-mediated Ca2+ mobilization in rabbit platelets.
European journal of pharmacology 1996;298(2):175-83.
1996: Tsukii K; Nakahata N; Watanabe K; Tsurufuji S; Ohizumi Y
Comparison of tBuBHQ with chemotactic peptide and phorbol ester in O2- production in HL-60 cells.
European journal of pharmacology 1996;298(1):87-95.
1996: Rho M C; Park Y H; Sasaki S; Ishibashi M; Kondo K; Kobayashi J; Ohizumi Y
The mode of rabbit platelet shape change and aggregation induced by theonezolide-A, a novel polyketide macrolide, isolated from the Okinawan marine sponge Theonella sp.
Canadian journal of physiology and pharmacology 1996;74(2):193-9.
1996: Sakai K; Nakahata N; Ono H; Yamamoto T; Ohizumi Y
Homologous desensitization of thromboxane A2 receptor in 1321N1 human astrocytoma cells.
The Journal of pharmacology and experimental therapeutics 1996;276(2):829-36.
1996: Nakahata N; Imata K; Okawa T; Watanabe Y; Ishimoto H; Ono T; Ohizumi Y; Nakanishi H
Mastoparan elicits prostaglandin E2 generation and inhibits inositol phosphate accumulation via different mechanisms in rabbit astrocytes.
Biochimica et biophysica acta 1996;1310(1):60-6.
1995: Nikai T; Suzuki J; Komori Y; Ohkura M; Ohizumi Y; Sugihara H
Primary structure of the lectin from the venom of Bitis arietans (puff-adder).
Biological & pharmaceutical bulletin 1995;18(11):1620-2.
1995: Mizuno K; Nakahata N; Ohizumi Y
Mastoparan-induced phosphatidylcholine hydrolysis by phospholipase D activation in human astrocytoma cells.
British journal of pharmacology 1995;116(3):2090-6.
1995: Yoshikawa K; Furukawa K; Yamamoto M; Momose K; Ohizumi Y
[3H]9-Methyl-7-bromoeudistomin D, a caffeine-like powerful Ca2+ releaser, binds to caffeine-binding sites distinct from the ryanodine receptors in brain microsomes.
FEBS letters 1995;373(3):250-4.
1995: Sakamoto H; Furukawa K; Matsunaga K; Nakamura H; Ohizumi Y
Xestoquinone activates skeletal muscle actomyosin ATPase by modification of the specific sulfhydryl group in the myosin head probably distinct from sulfhydryl groups SH1 and SH2.
Biochemistry 1995;34(39):12570-5.
1995: Ohkura M; Ide T; Furukawa K; Kawasaki T; Kasai M; Ohizumi Y
Calsequestrin is essential for the Ca2+ release induced by myotoxin alpha in skeletal muscle sarcoplasmic reticulum.
Canadian journal of physiology and pharmacology 1995;73(8):1181-5.
1995: Rho M C; Nakahata N; Nakamura H; Murai A; Ohizumi Y
Activation of rabbit platelets by Ca2+ influx and thromboxane A2 release in an external Ca(2+)-dependent manner by zooxanthellatoxin-A, a novel polyol.
British journal of pharmacology 1995;115(3):433-40.
1995: Ohkura M; Furukawa K; Oikawa K; Ohizumi Y
The properties of specific binding site of 125I-radioiodinated myotoxin a, a novel Ca++ releasing agent, in skeletal muscle sarcoplasmic reticulum.
The Journal of pharmacology and experimental therapeutics 1995;273(2):934-9.
1995: Nakahata N; Miyamoto A; Ohkubo S; Ishimoto H; Sakai K; Nakanishi H; Ohshika H; Ohizumi Y
Gq/11 communicates with thromboxane A2 receptors in human astrocytoma cells, rabbit astrocytes and human platelets.
Research communications in molecular pathology and pharmacology 1995;87(3):243-51.
1995: Takahashi Y; Furukawa K; Kozutsumi D; Ishibashi M; Kobayashi J; Ohizumi Y
4,6-Dibromo-3-hydroxycarbazole (an analogue of caffeine-like Ca2+ releaser), a novel type of inhibitor of Ca(2+)-induced Ca2+ release in skeletal muscle sarcoplasmic reticulum.
British journal of pharmacology 1995;114(5):941-8.
1995: Takahashi Y; Furukawa K; Ishibashi M; Kozutsumi D; Ishiyama H; Kobayashi J; Ohizumi Y
Structure-activity relationship of bromoeudistomin D, a powerful Ca2+ releaser in skeletal muscle sarcoplasmic reticulum.
European journal of pharmacology 1995;288(3):285-93.
1995: Matsunaga K; Shibuya M; Ohizumi Y
Imperanene, a novel phenolic compound with platelet aggregation inhibitory activity from Imperata cylindrica.
Journal of natural products 1995;58(1):138-9.
1994: Matsunaga K; Shibuya M; Ohizumi Y
Graminone B, a novel lignan with vasodilative activity from Imperata cylindrica.
Journal of natural products 1994;57(12):1734-6.
1994: Adachi M; Kakubari M; Ohizumi Y
Tissue- and subcellular-distribution of the binding site of [3H]9- methyl-7-bromoeudistomin D, a potent caffeine-like Ca2+ releaser, in rabbits.
The Journal of pharmacy and pharmacology 1994;46(9):774-6.
1994: Adachi M; Fang Y; Yamakuni T; Kobayashi J; Ohizumi Y
Properties of the binding sites of [3H]9-methyl-7-bromoeudistomin D in bovine aortic smooth muscle microsomes.
The Journal of pharmacy and pharmacology 1994;46(9):771-3.
1994: Furukawa K; Funayama K; Ohkura M; Oshima Y; Tu A T; Ohizumi Y
Ca2+ release induced by myotoxin alpha, a radio-labellable probe having novel Ca2+ release properties in sarcoplasmic reticulum.
British journal of pharmacology 1994;113(1):233-9.
1994: Matsunaga K; Ikeda M; Shibuya M; Ohizumi Y
Cylindol A, a novel biphenyl ether with 5-lipoxygenase inhibitory activity, and a related compound from Imperata Cylindrica.
Journal of natural products 1994;57(9):1290-3.
1994: Matsunaga K; Shibuya M; Ohizumi Y
Cylindrene, a novel sesquiterpenoid from Imperata cylindrica with inhibitory activity on contractions of vascular smooth muscle.
Journal of natural products 1994;57(8):1183-4.
1994: Seino A; Furukawa K; Miura T; Yaginuma T; Momose K; Ohizumi Y
3',3",5',5"-Tetraiodophenolsulfonephthalein is a selective inhibitor of Ca(2+)-pumping ATPase in intracellular Ca2+ store.
The Journal of biological chemistry 1994;269(26):17550-5.
1994: Ohkura M; Furukawa K; Tu A T; Ohizumi Y
Calsequestrin is a major binding protein of myotoxin alpha and an endogenous Ca2+ releaser in sarcoplasmic reticulum.
European journal of pharmacology 1994;268(1):R1-2.
1994: Nakahata N; Ishimoto H; Mizuno K; Ohizumi Y; Nakanishi H
Dual effects of mastoparan on intracellular free Ca2+ concentrations in human astrocytoma cells.
British journal of pharmacology 1994;112(1):299-303.
1994: Oshima Y; Yamada S; Matsunaga K; Moriya T; Ohizumi Y
A monogalactosyl diacylglycerol from a cultured marine dinoflagellate, Scrippsiella trochoidea.
Journal of natural products 1994;57(4):534-6.
1994: Adachi M; Kakubari M; Ohizumi Y
The specific binding site of 9-[3H]methyl-7-bromoeudistomin D, a caffeine-like Ca2+ releaser, in liver microsomes in distinct from that in skeletal sarcoplasmic reticulum.
Biological chemistry Hoppe-Seyler 1994;375(3):183-7.
1994: Nikai T; Komori Y; Ohara A; Yagihashi S; Ohizumi Y; Sugihara H
Characterization and amino-terminal sequence of phospholipase A2-II from the venom of Agkistrodon bilineatus (common cantil).
The International journal of biochemistry 1994;26(1):43-8.
1993: Furukawa K; Sakai K; Watanabe S; Maruyama K; Murakami M; Yamaguchi K; Ohizumi Y
Goniodomin A induces modulation of actomyosin ATPase activity mediated through conformational change of actin.
The Journal of biological chemistry 1993;268(34):26026-31.
1993: Subarnas A; Tadano T; Kisara K; Ohizumi Y
An alpha-adrenoceptor-mediated mechanism of hypoactivity induced by beta-amyrin palmitate.
The Journal of pharmacy and pharmacology 1993;45(11):1006-8.
1993: Fang Y I; Adachi M; Kobayashi J; Ohizumi Y
High affinity binding of 9-[3H]methyl-7-bromoeudistomin D to the caffeine-binding site of skeletal muscle sarcoplasmic reticulum.
The Journal of biological chemistry 1993;268(25):18622-5.
1993: Subarnas A; Tadano T; Oshima Y; Kisara K; Ohizumi Y
Pharmacological properties of beta-amyrin palmitate, a novel centrally acting compound, isolated from Lobelia inflata leaves.
The Journal of pharmacy and pharmacology 1993;45(6):545-50.
1993: Watanabe A; Ishida Y; Honda H; Kobayashi M; Ohizumi Y
Ca(2+)-dependent aggregation of rabbit platelets induced by maitotoxin, a potent marine toxin, isolated from a dinoflagellate.
British journal of pharmacology 1993;109(1):29-36.
1993: Ohizumi Y
[Tendency of development on novel type of cardiotonic drugs]
Nippon rinsho. Japanese journal of clinical medicine 1993;51(5):1299-304.
1993: Nakamura H; Asari T; Ohizumi Y; Kobayashi J; Yamasu T; Murai A
Isolation of zooxanthellatoxins, novel vasoconstrictive substances from the zooxanthella Symbiodinium sp.
Toxicon : official journal of the International Society on Toxinology 1993;31(4):371-6.
1993: Subarnas A; Tadano T; Nakahata N; Arai Y; Kinemuchi H; Oshima Y; Kisara K; Ohizumi Y
A possible mechanism of antidepressant activity of beta-amyrin palmitate isolated from Lobelia inflata leaves in the forced swimming test.
Life sciences 1993;52(3):289-96.
1992: Ohizumi Y
[Novel types of cardiotonic drugs]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1992;100(3):259-69.
1992: Subarnas A; Oshima Y; Sidik; Ohizumi Y
An antidepressant principle of Lobelia inflata L. (Campanulaceae).
Journal of pharmaceutical sciences 1992;81(7):620-1.
1992: Ohizumi Y
[Useful natural products for the biochemical study on muscle contractile systems]
Seikagaku. The Journal of Japanese Biochemical Society 1992;64(3):177-81.

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