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Junko Ohkanda

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TOP 3
Toshio Maki; Nobuo Kato; Akie Kawamura; Junko Ohkanda
Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein.
Carolin Anders; Maria Bartel; Jürgen Daut; Yusuke Higuchi; Nobuo Kato; Kristin Koschinsky; Hajime Nitta; Junko Ohkanda; Regina Preisig-Müller; Vijay Renigunta; Günter Schlichthörl; Benjamin Schumacher; Philipp Thiel; Christian Ottmann
A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface.
Koshi Kawakami; Yuriko Maruyama; Junko Ohkanda; Takeshi Sassa; Junji Suzumiy; Keizo Takenaga; Miki Tongu; Takaya Yamada; Miho Akimoto; Miho Hattori; Takatsugu Inoue; Nobuo Kato; Yoshio Honma
A novel fusicoccin derivative preferentially targets hypoxic tumor cells and inhibits tumor growth in xenografts.

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All Publications

2013: Toshio Maki; Nobuo Kato; Akie Kawamura; Junko Ohkanda
Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein.
Molecular bioSystems 2013;9(5):940-3.
2013: Carolin Anders; Maria Bartel; Jürgen Daut; Yusuke Higuchi; Nobuo Kato; Kristin Koschinsky; Hajime Nitta; Junko Ohkanda; Regina Preisig-Müller; Vijay Renigunta; Günter Schlichthörl; Benjamin Schumacher; Philipp Thiel; Christian Ottmann
A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface.
Chemistry & biology 2013;20(4):583-93.
2012: Koshi Kawakami; Yuriko Maruyama; Junko Ohkanda; Takeshi Sassa; Junji Suzumiy; Keizo Takenaga; Miki Tongu; Takaya Yamada; Miho Akimoto; Miho Hattori; Takatsugu Inoue; Nobuo Kato; Yoshio Honma
A novel fusicoccin derivative preferentially targets hypoxic tumor cells and inhibits tumor growth in xenografts.
Anti-cancer agents in medicinal chemistry 2012;12(7):791-800.
2012: Yoshinobu Yamaguchi; Hideki Azuma; Nobuo Kato; Takeshi Nagasaki; Junko Ohkanda
Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for α-chymotrypsin and cytochrome c.
Bioorganic & medicinal chemistry letters 2012;22(6):2354-8.
2012: Michiko Takahashi; Itaru Hamachi; Nobuo Kato; Akie Kawamura; Tsuyoshi Nishi; Junko Ohkanda
Phosphopeptide-dependent labeling of 14-3-3 ζ proteins by fusicoccin-based fluorescent probes.
Angewandte Chemie (International ed. in English) 2012;51(2):509-12.
2011: Shinnosuke Machida; Nobuo Kato; Kazuo Harada; Junko Ohkanda
Bivalent inhibitors for disrupting protein surface-substrate interactions and for dual inhibition of protein prenyltransferases.
Journal of the American Chemical Society 2011;133(4):958-63.
2009: Junko Ohkanda; Ritsuko Satoh; Nobuo Kato
Protein surface recognition by dendritic ruthenium(II) tris(bipyridine) complexes.
Chemical communications (Cambridge, England) 2009;(45):6949-51.
2009: Tomonobu Toyomasu; Mai Tsukahara; Hiromichi Kenmoku; Masahide Anada; Hajime Nitta; Junko Ohkanda; Wataru Mitsuhashi; Takeshi Sassa; Nobuo Kato
Transannular proton transfer in the cyclization of geranylgeranyl diphosphate to fusicoccadiene, a biosynthetic intermediate of fusicoccins.
Organic letters 2009;11(14):3044-7.
2009: Praveen Kumar Suryadevara; Srinivas Olepu; Jeffrey W Lockman; Junko Ohkanda; Mandana Karimi; Christophe Verlinde; James M Kraus; Jan Schoepe; Wesley C Van Voorhis; Andrew D Hamilton; Frederick S Buckner; Michael H Gelb
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.
Journal of medicinal chemistry 2009;52(12):3703-15.
2008: Shinnosuke Machida; Kakeru Usuba; Michelle A Blaskovich; Akiko Yano; Kazuo Harada; Saïd M Sebti; Nobuo Kato; Junko Ohkanda
Module assembly for protein-surface recognition: geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(5):1392-401.
2007: Frederic Delarue; Jalila Adnane; Bharat Joshi; Michelle A Blaskovich; De-an Wang; J Hawker; Francisco Bizouarn; Junko Ohkanda; K Zhu; Andrew D Hamilton; Srikumar Chellappan; Said M Sebti
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.
Oncogene 2007;26(5):633-40.
2006: Junko Ohkanda; Corey L Strickland; Michelle A Blaskovich; Dora Carrico; Jeffrey W Lockman; Andreas Vogt; Cynthia J Bucher; Jiazhi Sun; Yimin Qian; David Knowles; Erin E Pusateri; Said M Sebti; Andrew D Hamilton
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.
Organic & biomolecular chemistry 2006;4(3):482-92.
2004: Dora Carrico; Junko Ohkanda; Howard Kendrick; Kohei Yokoyama; Michelle A Blaskovich; Cynthia J Bucher; Frederick S Buckner; Wesley C Van Voorhis; Debopam Chakrabarti; Simon L Croft; Michael H Gelb; Said M Sebti; Andrew D Hamilton
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.
Bioorganic & medicinal chemistry 2004;12(24):6517-26.
2004: Junko Ohkanda; Frederick S Buckner; Jeffrey W Lockman; Kohei Yokoyama; Dora Carrico; Richard Eastman; Kate de Luca-Fradley; Wendy Davies; Simon L Croft; Wesley C Van Voorhis; Michael H Gelb; Said M Sebti; Andrew D Hamilton
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Journal of medicinal chemistry 2004;47(2):432-45.
2003: Jiazhi Sun; Junko Ohkanda; Domenico Coppola; Hang Yin; Mohit Kothare; Brian Busciglio; Andrew D Hamilton; Said M Sebti
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
Cancer research 2003;63(24):8922-9.
2003: Frederick S Buckner; Kohei Yokoyama; Jeffrey W Lockman; Kendra Aikenhead; Junko Ohkanda; Martin Sadilek; Said Sebti; Wesley C Van Voorhis; Andrew Hamilton; Michael H Gelb
A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15149-53.
2003: Bruno B Bordier; Junko Ohkanda; Ping Liu; So-Young Lee; F H Salazar; Patricia L Marion; Kazuo Ohashi; Leonard Meuse; Mark A Kay; John L Casey; Said M Sebti; Andrew D Hamilton; Jeffrey S Glenn
In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.
The Journal of clinical investigation 2003;112(3):407-14.
2003: Junko Ohkanda; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.
Progress in cell cycle research 2003;5():211-7.
2002: N C Crespo; Frederic Delarue; Junko Ohkanda; Dora Carrico; Andrew D Hamilton; Said M Sebti
The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.
Cell death and differentiation 2002;9(7):702-9.
2002: Junko Ohkanda; David B Knowles; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
Inhibitors of protein farnesyltransferase as novel anticancer agents.
Current topics in medicinal chemistry 2002;2(3):303-23.
2002: Junko Ohkanda; Jeffrey W Lockman; Mohit A Kothare; Yimin Qian; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.
Journal of medicinal chemistry 2002;45(1):177-88.
2002: Junko Ohkanda
[CAAX peptidomimetics: their farnesyltransferase inhibition activity and antitumor effect].
Seikagaku. The Journal of Japanese Biochemical Society 2002;74(1):46-50.
2001: N C Crespo; Junko Ohkanda; T J Yen; Andrew D Hamilton; Said M Sebti
The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.
The Journal of biological chemistry 2001;276(19):16161-7.
2001: Junko Ohkanda; Jeffrey W Lockman; Kohei Yokoyama; Michael H Gelb; Simon L Croft; H Kendrick; M I Harrell; JE Feagin; Michelle A Blaskovich; Said M Sebti; Andrew D Hamilton
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Bioorganic & medicinal chemistry letters 2001;11(6):761-4.
2000: Jalila Adnane; Francisco Bizouarn; Zhi Chen; Junko Ohkanda; Andrew D Hamilton; T Munoz-Antonia; Said M Sebti
Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.
Oncogene 2000;19(48):5525-33.
1999: J Sun; Michelle A Blaskovich; D Knowles; Y Qian; Junko Ohkanda; Ratna D Bailey; Andrew D Hamilton; Said M Sebti
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.
Cancer research 1999;59(19):4919-26.
1999: A Vasudevan; Yimin Qian; Andreas Vogt; Michelle A Blaskovich; Junko Ohkanda; Said M Sebti; Andrew D Hamilton
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.
Journal of medicinal chemistry 1999;42(8):1333-40.
1998: Umberto Kucich; J C Rosenbloom; G Shen; William Abrams; Michelle A Blaskovich; Andrew D Hamilton; Junko Ohkanda; Said M Sebti; Joel Rosenbloom
Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization.
Biochemical and biophysical research communications 1998;252(1):111-6.