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Hiroshi Ohnishi

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Yuriko Hayashi; Takenori Kotani; Shinya Kusakari; Takashi Matozaki; Hirokazu Murakami; Yoji Murata; Miho Sato-Hashimoto; Tsuneo Sekijima; Masahiro Shigeno; Eriko Urano; Hiroshi Ohnishi
Hypothermia-dependent and -independent effects of forced swim on the phosphorylation states of signaling molecules in mouse hippocampus.
Takashi Nakakura; Hiroshi Ohnishi; Akihiro Harada; Tadahiro Kitamura; Masaki Kobayashi; Chihiro Mogi; Koichi Sato; Tetsuya Sugiyama; Shigeyasu Tanaka; Masayuki Tobo; Hideaki Tomura; Mitsutoshi Wayama; Fumikazu Okajima
Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.
Tetsuya Kaneko; Yoriaki Kaneko; Takenori Kotani; Shinya Kusakari; Keiju Hiromura; Hiroko Iwamura; Yoshitake Kanazawa; Yoji Murata; Yoshihisa Nojima; Hiroshi Ohnishi; Hideki Okazawa; Yasuyuki Saito; Miho Sato-Hashimoto; Kenji Takagishi; Satoshi Takahashi; Takashi Matozaki
Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity.

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All Publications

2012: Yuriko Hayashi; Takenori Kotani; Shinya Kusakari; Takashi Matozaki; Hirokazu Murakami; Yoji Murata; Miho Sato-Hashimoto; Tsuneo Sekijima; Masahiro Shigeno; Eriko Urano; Hiroshi Ohnishi
Hypothermia-dependent and -independent effects of forced swim on the phosphorylation states of signaling molecules in mouse hippocampus.
Biochemical and biophysical research communications 2012;428(4):475-81.
2012: Takashi Nakakura; Hiroshi Ohnishi; Akihiro Harada; Tadahiro Kitamura; Masaki Kobayashi; Chihiro Mogi; Koichi Sato; Tetsuya Sugiyama; Shigeyasu Tanaka; Masayuki Tobo; Hideaki Tomura; Mitsutoshi Wayama; Fumikazu Okajima
Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.
Endocrinology 2012;153(9):4171-80.
2012: Tetsuya Kaneko; Yoriaki Kaneko; Takenori Kotani; Shinya Kusakari; Keiju Hiromura; Hiroko Iwamura; Yoshitake Kanazawa; Yoji Murata; Yoshihisa Nojima; Hiroshi Ohnishi; Hideki Okazawa; Yasuyuki Saito; Miho Sato-Hashimoto; Kenji Takagishi; Satoshi Takahashi; Takashi Matozaki
Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(11):5397-407.
2012: Toshi Maruyama; Takashi Matozaki; Yoji Murata; Yuriko Hayashi; Shoji Kishi; Takenori Kotani; Shinya Kusakari; Hideki Okazawa; Per-Arne Oldenborg; Miho Sato-Hashimoto; Hiroshi Ohnishi
Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain.
Journal of neurochemistry 2012;121(6):891-902.
2012: Takashi Nakamura; Hisataka Nishida; Hiroshi Ohnishi; Tohru Sekino; Xuehua Tang; Hirofumi Usami; Kazumichi Wakabayashi; Hirofumi Yatani
The relationship between milling a new silica-doped zirconia and its resistance to low-temperature degradation (LTD): a pilot study.
Dental materials journal 2012;31(1):106-12.
2011: Hiroshi Ohnishi; Hideki Okazawa; Yoji Murata; Takashi Matozaki
Src family kinases: modulators of neurotransmitter receptor function and behavior.
Trends in neurosciences 2011;34(12):629-37.
2011: Hiroshi Ohnishi
[Regulation of the adult brain function by Src family tyrosine kinases].
Seikagaku. The Journal of Japanese Biochemical Society 2011;83(11):1054-9.
2011: Miho Sato-Hashimoto; Carl F Ware; Hiroko Iwamura; Yoshitake Kanazawa; Tetsuya Kaneko; Takenori Kotani; Shinya Kusakari; Munemasa Mori; Yoji Murata; Yoshihisa Nojima; Hiroshi Ohnishi; Hideki Okazawa; Per-Arne Oldenborg; Yasuyuki Saito; Takashi Matozaki
Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):291-7.
2011: Hiroko Iwamura; Yasuyuki Saito; Miho Sato-Hashimoto; Hiroshi Ohnishi; Yoji Murata; Hideki Okazawa; Yoshitake Kanazawa; Tetsuya Kaneko; Shinya Kusakari; Takenori Kotani; Yoshihisa Nojima; Takashi Matozaki
Essential roles of SIRPα in homeostatic regulation of skin dendritic cells.
Immunology letters 2011;135(1-2):100-7.
2011: Takashi Nakamura; Hirofumi Usami; Hiroshi Ohnishi; Miyuki Takeuchi; Hisataka Nishida; Tohru Sekino; Hirofumi Yatani
The effect of adding silica to zirconia to counteract zirconia's tendency to degrade at low temperatures.
Dental materials journal 2011;30(3):330-5.
2010: Yoshitake Kanazawa; Yasuyuki Saito; Yana Supriatna; Hiroyuki Tezuka; Takenori Kotani; Yoji Murata; Hideki Okazawa; Hiroshi Ohnishi; Yoshitaka Kinouchi; Yoshihisa Nojima; Toshiaki Ohteki; Tooru Shimosegawa; Takashi Matozaki
Role of SIRPα in regulation of mucosal immunity in the intestine.
Genes to cells : devoted to molecular & cellular mechanisms 2010;15(12):1189-200.
2010: Takashi Matozaki; Yoji Murata; Munemasa Mori; Takenori Kotani; Hideki Okazawa; Hiroshi Ohnishi
Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals.
Cellular signalling 2010;22(12):1811-7.
2010: Yasuyuki Saito; Hiroko Iwamura; Tetsuya Kaneko; Hiroshi Ohnishi; Yoji Murata; Hideki Okazawa; Yoshitake Kanazawa; Miho Sato-Hashimoto; Hisae Kobayashi; Per-Arne Oldenborg; Makoto Naito; Yoriaki Kaneko; Yoshihisa Nojima; Takashi Matozaki
Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues.
Blood 2010;116(18):3517-25.
2010: Naoko Morimoto; Yoji Murata; Sei-ichiro Motegi; Kazutomo Suzue; Yasuyuki Saito; Hideki Okazawa; Hiroshi Ohnishi; Takenori Kotani; Shinya Kusakari; Osamu Ishikawa; Takashi Matozaki
Requirement of SIRPα for protective immunity against Leishmania major.
Biochemical and biophysical research communications 2010;401(3):385-9.
2010: Hiroshi Ohnishi; Takaaki Murata; Shinya Kusakari; Yuriko Hayashi; Keizo Takao; Toshi Maruyama; Yukio Ago; Ken Koda; Feng Jie Jin; Katsuya Okawa; Per-Arne Oldenborg; Hideki Okazawa; Yoji Murata; Nobuhiko Furuya; Toshio Matsuda; Tsuyoshi Miyakawa; Takashi Matozaki
Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(31):10472-83.
2010: Masatomo Mori; Yoji Murata; Takenori Kotani; Shinya Kusakari; Hiroshi Ohnishi; Yasuyuki Saito; Hideki Okazawa; Tamotsu Ishizuka; Masatomo Mori; Takashi Matozaki
Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins.
Journal of cellular physiology 2010;224(1):195-204.
2010: Yoji Murata; Munemasa Mori; Takenori Kotani; Yana Supriatna; Hideki Okazawa; Shinya Kusakari; Yasuyuki Saito; Hiroshi Ohnishi; Takashi Matozaki
Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn.
Genes to cells : devoted to molecular & cellular mechanisms 2010;15(5):513-24.
2010: Takenori Kotani; Yoji Murata; Hiroshi Ohnishi; Munemasa Mori; Shinya Kusakari; Yasuyuki Saito; Hideki Okazawa; John L Bixby; Takashi Matozaki
Expression of PTPRO in the interneurons of adult mouse olfactory bulb.
The Journal of comparative neurology 2010;518(2):119-36.
2009: Takashi Matozaki; Yoji Murata; Yasuyuki Saito; Hideki Okazawa; Hiroshi Ohnishi
Protein tyrosine phosphatase SHP-2: a proto-oncogene product that promotes Ras activation.
Cancer science 2009;100(10):1786-93.
2009: Hisanobu Sadakata; Hideki Okazawa; Takashi Sato; Yana Supriatna; Hiroshi Ohnishi; Shinya Kusakari; Yoji Murata; Tomokazu Ito; Uichi Nishiyama; Takashi Minegishi; Akihiro Harada; Takashi Matozaki
SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(3):295-308.
2009: Takashi Matozaki; Yoji Murata; Hideki Okazawa; Hiroshi Ohnishi
Functions and molecular mechanisms of the CD47-SIRPalpha signalling pathway.
Trends in cell biology 2009;19(2):72-80.
2008: Masaki Kobayashi; Hiroshi Ohnishi; Hideki Okazawa; Yoji Murata; Yuriko Hayashi; Hisae Kobayashi; Tadahiro Kitamura; Takashi Matozaki
Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes.
Endocrinology 2008;149(11):5662-9.
2008: Chie Okuzawa; Yoriaki Kaneko; Yoji Murata; Astuko Miyake; Yasuyuki Saito; Jun Okajo; Takeshi Tomizawa; Yuka Kaneko; Hideki Okazawa; Hiroshi Ohnishi; Takashi Matozaki; Yoshihisa Nojima
Resistance to collagen-induced arthritis in SHPS-1 mutant mice.
Biochemical and biophysical research communications 2008;371(3):561-6.
2008: Shinya Kusakari; Hiroshi Ohnishi; Feng Jie Jin; Yuka Kaneko; Takaaki Murata; Yoji Murata; Hideki Okazawa; Takashi Matozaki
Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system.
Journal of cell science 2008;121(Pt 8):1213-23.
2008: Atsuko Miyake; Yoji Murata; Hideki Okazawa; Hiroshi Ikeda; Yuriko Niwayama; Hiroshi Ohnishi; Yukio Hirata; Takashi Matozaki
Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages.
Genes to cells : devoted to molecular & cellular mechanisms 2008;13(2):209-19.
2008: Aki Nakaishi; Mayumi Hirose; Masato Yoshimura; Chitose Oneyama; Kazunobu Saito; Nobuharu Kuki; Makoto Matsuda; Nakayuki Honma; Hiroshi Ohnishi; Takashi Matozaki; Masato Okada; Atsushi Nakagawa
Structural insight into the specific interaction between murine SHPS-1/SIRP alpha and its ligand CD47.
Journal of molecular biology 2008;375(3):650-60.
2007: Takeshi Tomizawa; Yoriaki Kaneko; Yuka Kaneko; Yasuyuki Saito; Hiroshi Ohnishi; Jun Okajo; Chie Okuzawa; Tomomi Ishikawa-Sekigami; Yoji Murata; Hideki Okazawa; Koichi Okamoto; Yoshihisa Nojima; Takashi Matozaki
Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 mutant mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):869-77.
2007: Jun Okajo; Yuka Kaneko; Yoji Murata; Takeshi Tomizawa; Chie Okuzawa; Yasuyuki Saito; Yoriaki Kaneko; Tomomi Ishikawa-Sekigami; Hideki Okazawa; Hiroshi Ohnishi; Takashi Matozaki; Yoshihisa Nojima
Regulation by Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 of alpha-galactosylceramide-induced antimetastatic activity and Th1 and Th2 responses of NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6164-72.
2006: Takaaki Murata; Hiroshi Ohnishi; Hideki Okazawa; Yoji Murata; Shinya Kusakari; Yuriko Hayashi; Motoaki Miyashita; Hiroshi Itoh; Per-Arne Oldenborg; Nobuhiko Furuya; Takashi Matozaki
CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(48):12397-407.
2006: Hiroshi Ikeda; Hideki Okazawa; Hiroshi Ohnishi; Yoji Murata; Per-Arne Oldenborg; Takashi Matozaki
Mutational analysis of the mechanism of negative regulation by SRC homology 2 domain-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3123-32.
2006: Masahiko Shinohara; Naoko Ohyama; Yoji Murata; Hideki Okazawa; Hiroshi Ohnishi; Osamu Ishikawa; Takashi Matozaki
CD47 regulation of epithelial cell spreading and migration, and its signal transduction.
Cancer science 2006;97(9):889-95.
2006: Tomomi Ishikawa-Sekigami; Yoriaki Kaneko; Yasuyuki Saito; Yoji Murata; Hideki Okazawa; Hiroshi Ohnishi; Per-Arne Oldenborg; Yoshihisa Nojima; Takashi Matozaki
Enhanced phagocytosis of CD47-deficient red blood cells by splenic macrophages requires SHPS-1.
Biochemical and biophysical research communications 2006;343(4):1197-200.
2006: Aki Nagata; Hiroshi Ohnishi; Masato Yoshimura; Akira Ogawa; Sayuri Ujita; Hiroaki Adachi; Masato Okada; Takashi Matozaki; Atsushi Nakagawa
Crystallization and preliminary X-ray analysis of rat SHPS-1.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 3):189-91.
2006: Tomomi Ishikawa-Sekigami; Yoriaki Kaneko; Hideki Okazawa; Takeshi Tomizawa; Jun Okajo; Yasuyuki Saito; Chie Okuzawa; Minako Sugawara-Yokoo; Uichi Nishiyama; Hiroshi Ohnishi; Takashi Matozaki; Yoshihisa Nojima
SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages.
Blood 2006;107(1):341-8.
2005: Takashi Matozaki; Hiroshi Ohnishi
[SHP tyrosine phosphatases and a novel cell-cell signaling system].
Seikagaku. The Journal of Japanese Biochemical Society 2005;77(10):1299-307.
2005: Hiroshi Ohnishi; Yuka Kaneko; Hideki Okazawa; Motoaki Miyashita; Ryuji Sato; Akiko Hayashi; Kazutoshi Tada; Shigekazu Nagata; Masami Takahashi; Takashi Matozaki
Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(10):2702-11.
2005: Hideki Okazawa; Sei-ichiro Motegi; Naoko Ohyama; Hiroshi Ohnishi; Takeshi Tomizawa; Yoriaki Kaneko; Per-Arne Oldenborg; Osamu Ishikawa; Takashi Matozaki
Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2004-11.
2004: Motoaki Miyashita; Hiroshi Ohnishi; Hideki Okazawa; Hiroyasu Tomonaga; Akiko Hayashi; Tetsuro-Takahiro Fujimoto; Nobuhiko Furuya; Takashi Matozaki
Promotion of neurite and filopodium formation by CD47: roles of integrins, Rac, and Cdc42.
Molecular biology of the cell 2004;15(8):3950-63.
2004: Akiko Hayashi; Hiroshi Ohnishi; Hideki Okazawa; Seshiru Nakazawa; Hiroshi Ikeda; Sei-ichiro Motegi; Naoko Aoki; Shoji Kimura; Masahiko Mikuni; Takashi Matozaki
Positive regulation of phagocytosis by SIRPbeta and its signaling mechanism in macrophages.
The Journal of biological chemistry 2004;279(28):29450-60.
2004: Hiroshi Ohnishi; Hisae Kobayashi; Hideki Okazawa; Yoshihide Ohe; Kyoko Tomizawa; Ryuji Sato; Takashi Matozaki
Ectodomain shedding of SHPS-1 and its role in regulation of cell migration.
The Journal of biological chemistry 2004;279(27):27878-87.
2003: Ryuji Sato; Hiroshi Ohnishi; Hisae Kobayashi; Daisuke Kiuchi; Akiko Hayashi; Yuka Kaneko; Nakayuki Honma; Hideki Okazawa; Yukio Hirata; Takashi Matozaki
Regulation of multiple functions of SHPS-1, a transmembrane glycoprotein, by its cytoplasmic region.
Biochemical and biophysical research communications 2003;309(3):584-90.
2003: Tomokazu Ito; Hideki Okazawa; Koji Maruyama; Kyoko Tomizawa; Sei-ichiro Motegi; Hiroshi Ohnishi; Hiroyuki Kuwano; Atsushi Kosugi; Takashi Matozaki
Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function.
The Journal of biological chemistry 2003;278(37):34854-63.
2003: Yoshihide Ohe; Hiroshi Ohnishi; Hideki Okazawa; Kyoko Tomizawa; Hisae Kobayashi; Katsuya Okawa; Takashi Matozaki
Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain.
Biochemical and biophysical research communications 2003;308(4):719-25.
2003: Sei-ichiro Motegi; Hideki Okazawa; Hiroshi Ohnishi; Ryuji Sato; Yoriaki Kaneko; Hisae Kobayashi; Kyoko Tomizawa; Tomokazu Ito; Nakayuki Honma; Hans-Jörg Bühring; Osamu Ishikawa; Takashi Matozaki
Role of the CD47-SHPS-1 system in regulation of cell migration.
The EMBO journal 2003;22(11):2634-44.
2002: Hiroshi Ohnishi
[Regulation of neurotransmitter release by tyrosine kinases].
Seikagaku. The Journal of Japanese Biochemical Society 2002;74(2):127-30.
2000: Toshiyuki Araki; Masashi Yamada; Hiroshi Ohnishi; S i Sano; Hiroshi Hatanaka
BIT/SHPS-1 enhances brain-derived neurotrophic factor-promoted neuronal survival in cultured cerebral cortical neurons.
Journal of neurochemistry 2000;75(4):1502-10.
2000: Toshiyuki Araki; Masashi Yamada; Hiroshi Ohnishi; S i Sano; Taichi Uetsuki; Hiroshi Hatanaka
Shp-2 specifically regulates several tyrosine-phosphorylated proteins in brain-derived neurotrophic factor signaling in cultured cerebral cortical neurons.
Journal of neurochemistry 2000;74(2):659-68.
1999: Masashi Yamada; Hiroshi Ohnishi; S i Sano; Toshiyuki Araki; Atsutoshi Nakatani; Toshihiko Ikeuchi; Hiroshi Hatanaka
Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons.
Journal of neurochemistry 1999;73(1):41-9.
1997: Masashi Yamada; Hiroshi Ohnishi; S i Sano; Atsutoshi Nakatani; Toshihiko Ikeuchi; Hiroshi Hatanaka
Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons.
The Journal of biological chemistry 1997;272(48):30334-9.