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Hiroaki Ohno

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Zengye Hou; Tatsuhide Kure; Isao Nakanishi; Hiroaki Ohno; Shinya Oishi; Yamato Suzuki; Gozoh Tsujimoto; Akira Hirasawa; Nobutaka Fujii
Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors.
Ryosuke Misu; Jean-Marc Navenot; Taro Noguchi; Hiroaki Ohno; Shinya Oishi; Stephen Peiper; Shohei Setsuda; Barry Evans; Masato Kaneda; Nobutaka Fujii
Characterization of the receptor binding residues of kisspeptins by positional scanning using peptide photoaffinity probes.
Ryosuke Misu; Taro Noguchi; Hiroaki Ohno; Shinya Oishi; Nobutaka Fujii
Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists.

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2013: Zengye Hou; Tatsuhide Kure; Isao Nakanishi; Hiroaki Ohno; Shinya Oishi; Yamato Suzuki; Gozoh Tsujimoto; Akira Hirasawa; Nobutaka Fujii
Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors.
Organic & biomolecular chemistry 2013;11(20):3288-96.
2013: Ryosuke Misu; Jean-Marc Navenot; Taro Noguchi; Hiroaki Ohno; Shinya Oishi; Stephen Peiper; Shohei Setsuda; Barry Evans; Masato Kaneda; Nobutaka Fujii
Characterization of the receptor binding residues of kisspeptins by positional scanning using peptide photoaffinity probes.
Bioorganic & medicinal chemistry letters 2013;23(9):2628-31.
2013: Ryosuke Misu; Taro Noguchi; Hiroaki Ohno; Shinya Oishi; Nobutaka Fujii
Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists.
Bioorganic & medicinal chemistry 2013;21(8):2413-7.
2013: Tsukasa Mizuhara; Hiroaki Ohno; Shinya Oishi; Kazuya Shimura; Masao Matsuoka; Nobutaka Fujii
Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182.
Bioorganic & medicinal chemistry 2013;21(7):2079-87.
2012: Tsukasa Mizuhara; Hiroaki Ohno; Shinya Oishi; Kazuya Shimura; Masao Matsuoka; Nobutaka Fujii
Structure-activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents.
Bioorganic & medicinal chemistry 2012;20(21):6434-41.
2012: Tsukasa Mizuhara; Hiroaki Ohno; Shinya Oishi; Kazuya Shimura; Masao Matsuoka; Nobutaka Fujii
Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles.
Organic & biomolecular chemistry 2012;10(33):6792-802.
2012: Hiroaki Chiba; Nobutaka Fujii; Shinya Oishi; Hiroaki Ohno
Total synthesis of (-)-quinocarcin by gold(I)-catalyzed regioselective hydroamination.
Angewandte Chemie (International ed. in English) 2012;51(36):9169-72.
2012: Yamato Suzuki; Yoshinori Takei; Gozoh Tsujimoto; Misato Yasue; Akira Hirasawa; Zengye Hou; Tatsuhide Kure; Ryosuke Misu; Isao Nakanishi; Saori Naoe; Hiroaki Ohno; Shinya Oishi; Nobutaka Fujii
Design and synthesis of a novel class of CK2 inhibitors: application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles.
Organic & biomolecular chemistry 2012;10(25):4907-15.
2012: Saori Naoe; Nobutaka Fujii; Kimio Hirano; Yusuke Inaba; Shinya Oishi; Yamato Suzuki; Hiroaki Ohno
Gold(I)-catalyzed regioselective inter-/intramolecular addition cascade of di- and triynes for direct construction of substituted naphthalenes.
The Journal of organic chemistry 2012;77(11):4907-16.
2012: Ryo Masuda; Masao Matsuoka; Hiroaki Ohno; Shinya Oishi; Noriko Tanahara; Gozoh Tsujimoto; Akira Hirasawa; Eiichi Kodama; Nobutaka Fujii
Development and application of fluorescent SDF-1 derivatives.
Future medicinal chemistry 2012;4(7):837-44.
2012: Hiroaki Ohno; Nobutaka Fujii; Mutsumi Iuchi; Naoto Kojima; Takehiko Yoshimitsu; Tetsuaki Tanaka
Double C-H functionalization in sequential order: direct synthesis of polycyclic compounds by a palladium-catalyzed C-H alkenylation-arylation cascade.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(17):5352-60.
2012: Kazuya Kobayashi; Yuka Kobayashi; Hiroaki Ohno; Shinya Oishi; Hiroko Tsutsumi; Yoji Hata; Nobutaka Fujii
Synthesis and application of an Nδ-acetyl-Nδ-hydroxyornithine analog: identification of novel metal complexes of deferriferrichrysin.
Bioorganic & medicinal chemistry 2012;20(8):2651-5.
2012: Kazuya Kobayashi; Tatsuhiko Kubo; Hiroaki Ohno; Shinya Oishi; Noriko Tanahara; Kenji Tomita; Yasushi Yoshikawa; Toshio Furuya; Ryoko Hayashi; Masaru Hoshino; Nobutaka Fujii
Structure-activity relationship study of a CXC chemokine receptor type 4 antagonist, FC131, using a series of alkene dipeptide isosteres.
Journal of medicinal chemistry 2012;55(6):2746-57.
2012: Zengye Hou; Takayoshi Kinoshita; Kazuo Kitaura; Tatsuhide Kure; Ryosuke Misu; Katsumi Murata; Shinya Nakamura; Isao Nakanishi; Hiroaki Ohno; Shinya Oishi; Yamato Suzuki; Yoshinori Takei; Gozoh Tsujimoto; Misato Yasue; Akira Hirasawa; Nobutaka Fujii
Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds.
Journal of medicinal chemistry 2012;55(6):2899-903.
2011: Kimio Hirano; Yusuke Inaba; Shinya Oishi; Kiyosei Takasu; Yoshiji Takemoto; Nobutaka Fujii; Hiroaki Ohno
Gold(I)-catalyzed polycyclizations of polyenyne-type anilines based on hydroamination and consecutive hydroarylation cascade.
The Journal of organic chemistry 2011;76(21):9068-80.
2011: Yuji Yoshimitsu; Shinsuke Inuki; Jun Miyagaki; Hiroaki Ohno; Shinya Oishi; Nobutaka Fujii
Pachastrissamine (jaspine B) and its stereoisomers inhibit sphingosine kinases and atypical protein kinase C.
Bioorganic & medicinal chemistry 2011;19(18):5402-8.
2011: Tomoki Takeuchi; Toshiaki Watanabe; Naoya Asada; Akira Asai; Kazuo Kitaura; Kenji Matsuno; Hiroaki Ohno; Shinya Oishi; Jun-ichi Sawada; Nobutaka Fujii
Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.
Journal of medicinal chemistry 2011;54(13):4839-46.
2011: Akira Iwata; Nobutaka Fujii; Shinsuke Inuki; Shinya Oishi; Hiroaki Ohno
Formal total synthesis of (+)-lysergic acid via zinc(II)-mediated regioselective ring-opening reduction of 2-alkynyl-3-indolyloxirane.
The Journal of organic chemistry 2011;76(13):5506-12.
2011: Ryo Masuda; Shinya Oishi; Hiroaki Ohno; Hiroyuki Kimura; Hideo Saji; Nobutaka Fujii
Concise site-specific synthesis of DTPA-peptide conjugates: application to imaging probes for the chemokine receptor CXCR4.
Bioorganic & medicinal chemistry 2011;19(10):3216-20.
2011: Eriko Inokuchi; Ai Yamada; Kentaro Hozumi; Kenji Tomita; Shinya Oishi; Hiroaki Ohno; Motoyoshi Nomizu; Nobutaka Fujii
Design and synthesis of amidine-type peptide bond isosteres: application of nitrile oxide derivatives as active ester equivalents in peptide and peptidomimetics synthesis.
Organic & biomolecular chemistry 2011;9(9):3421-7.
2011: Shinsuke Inuki; Akira Iwata; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Enantioselective total synthesis of (+)-lysergic acid, (+)-lysergol, and (+)-isolysergol by palladium-catalyzed domino cyclization of allenes bearing amino and bromoindolyl groups.
The Journal of organic chemistry 2011;76(7):2072-83.
2011: Kimio Hirano; Yusuke Inaba; Naoya Takahashi; Masanao Shimano; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Direct synthesis of fused indoles by gold-catalyzed cascade cyclization of diynes.
The Journal of organic chemistry 2011;76(5):1212-27.
2010: Yusuke Ohta; Yusuke Tokimizu; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Direct synthesis of quinazolines through copper-catalyzed reaction of aniline-derived benzamidines.
Organic letters 2010;12(17):3963-5.
2010: Akinori Okano; Koji Tsukamoto; Shohei Kosaka; Hatsuo Maeda; Shinya Oishi; Tetsuaki Tanaka; Nobutaka Fujii; Hiroaki Ohno
Synthesis of fused and linked bicyclic nitrogen heterocycles by palladium-catalyzed domino cyclization of propargyl bromides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(28):8410-8.
2010: Shinya Oishi; Toshiaki Watanabe; Jun-Ichi Sawada; Akira Asai; Hiroaki Ohno; Nobutaka Fujii
Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.
Journal of medicinal chemistry 2010;53(13):5054-8.
2010: Shinsuke Inuki; Yuji Yoshimitsu; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Ring-construction/stereoselective functionalization cascade: total synthesis of pachastrissamine (jaspine B) through palladium-catalyzed bis-cyclization of propargyl chlorides and carbonates.
The Journal of organic chemistry 2010;75(11):3831-42.
2010: Yuji Yoshimitsu; Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Stereoselective divergent synthesis of four diastereomers of pachastrissamine (jaspine B).
The Journal of organic chemistry 2010;75(11):3843-6.
2010: Akinori Okano; Shinya Oishi; Tetsuaki Tanaka; Nobutaka Fujii; Hiroaki Ohno
Construction of linked nitrogen heterocycles by palladium(0)-catalyzed intramolecular domino cyclization of 2-alkynylaziridines bearing a 2-aminoethyl group via ring expansion with isocyanate.
The Journal of organic chemistry 2010;75(10):3396-400.
2010: Tetsuo Narumi; Ryoko Hayashi; Kenji Tomita; Kazuya Kobayashi; Noriko Tanahara; Hiroaki Ohno; Takeshi Naito; Eiichi Kodama; Masao Matsuoka; Shinya Oishi; Nobutaka Fujii
Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres.
Organic & biomolecular chemistry 2010;8(3):616-21.
2010: Tsukasa Mizuhara; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Efficient synthesis of pyrimido[1,2-c] [1,3]benzothiazin-6-imines and related tricyclic heterocycles by S(N)Ar-type C-S, C-N, or C-O bond formation with heterocumulenes.
The Journal of organic chemistry 2010;75(1):265-8.
2009: Kazumi Kajiwara; Kentaro Watanabe; Rei Tokiwa; Tomoko Kurose; Hiroaki Ohno; Hiroko Tsutsumi; Yoji Hata; Kazuki Izumi; Eiichi Kodama; Masao Matsuoka; Shinya Oishi; Nobutaka Fujii
Bioorganic synthesis of a recombinant HIV-1 fusion inhibitor, SC35EK, with an N-terminal pyroglutamate capping group.
Bioorganic & medicinal chemistry 2009;17(23):7964-70.
2009: Michinori Tanaka; Kazumi Kajiwara; Rei Tokiwa; Kentaro Watanabe; Hiroaki Ohno; Hiroko Tsutsumi; Yoji Hata; Kazuki Izumi; Eiichi Kodama; Masao Matsuoka; Shinya Oishi; Nobutaka Fujii
Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins.
Bioorganic & medicinal chemistry 2009;17(21):7487-92.
2009: Shinsuke Inuki; Yuji Yoshimitsu; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Ring-construction/stereoselective functionalization cascade: total synthesis of pachastrissamine (jaspine B) through palladium-catalyzed bis-cyclization of bromoallenes.
Organic letters 2009;11(19):4478-81.
2009: Tsuyoshi Watabe; Yukihiro Terakawa; Kentaro Watanabe; Hiroaki Ohno; Hiroaki Nakano; Toru Nakatsu; Hiroaki Kato; Kazuki Izumi; Eiichi Kodama; Masao Matsuoka; Kazuo Kitaura; Shinya Oishi; Nobutaka Fujii
X-ray crystallographic study of an HIV-1 fusion inhibitor with the gp41 S138A substitution.
Journal of molecular biology 2009;392(3):657-65.
2009: Yusuke Ohta; Hiroaki Chiba; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Construction of nitrogen heterocycles bearing an aminomethyl group by copper-catalyzed domino three-component coupling-cyclization.
The Journal of organic chemistry 2009;74(18):7052-8.
2009: Yusuke Ohta; Yushi Kubota; Tsuyoshi Watabe; Hiroaki Chiba; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Rapid access to 3-(aminomethyl)isoquinoline-fused polycyclic compounds by copper-catalyzed four-component coupling, cascade cyclization, and oxidation.
The Journal of organic chemistry 2009;74(16):6299-302.
2009: Shinya Oishi; Hirotaka Kamitani; Yasuyo Kodera; Kentaro Watanabe; Kazuya Kobayashi; Tetsuo Narumi; Kenji Tomita; Hiroaki Ohno; Takeshi Naito; Eiichi Kodama; Masao Matsuoka; Nobutaka Fujii
Peptide bond mimicry by (E)-alkene and (Z)-fluoroalkene peptide isosteres: synthesis and bioevaluation of alpha-helical anti-HIV peptide analogues.
Organic & biomolecular chemistry 2009;7(14):2872-7.
2009: Shinya Oishi; Yasuyo Kodera; Hiroki Nishikawa; Hirotaka Kamitani; Tsuyoshi Watabe; Hiroaki Ohno; Tadafumi Tochikura; Kazuki Shimane; Eiichi Kodama; Masao Matsuoka; Fuminori Mizukoshi; Hajime Tsujimoto; Nobutaka Fujii
Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus.
Bioorganic & medicinal chemistry 2009;17(14):4916-20.
2009: Toshiaki Watanabe; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Palladium-catalyzed direct synthesis of carbazoles via one-pot N-arylation and oxidative biaryl coupling: synthesis and mechanistic study.
The Journal of organic chemistry 2009;74(13):4720-6.
2009: Tsukasa Mizuhara; Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Cu(II)-mediated oxidative intermolecular ortho C-H functionalisation using tetrahydropyrimidine as the directing group.
Chemical communications (Cambridge, England) 2009;(23):3413-5.
2009: Kazuya Kobayashi; Tetsuo Narumi; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii
Amino acid-based synthesis of trifluoromethylalkene dipeptide isosteres by alcohol-assisted nucleophilic trifluoromethylation and organozinc-copper-mediated S(N)2' alkylation.
The Journal of organic chemistry 2009;74(12):4626-9.
2009: Yamato Suzuki; Yusuke Ohta; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Efficient synthesis of aminomethylated pyrroloindoles and dipyrrolopyridines via controlled copper-catalyzed domino multicomponent coupling and bis-cyclization.
The Journal of organic chemistry 2009;74(11):4246-51.
2009: Yusuke Ohta; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Facile synthesis of 1,2,3,4-tetrahydro-beta-carbolines by one-pot domino three-component indole formation and nucleophilic cyclization.
Organic letters 2009;11(9):1979-82.
2009: Kenji Tomita; H Akiko Popiel; Yoshitaka Nagai; Tatsushi Toda; Yuji Yoshimitsu; Hiroaki Ohno; Shinya Oishi; Nobutaka Fujii
Structure-activity relationship study on polyglutamine binding peptide QBP1.
Bioorganic & medicinal chemistry 2009;17(3):1259-63.
2009: Shinya Oishi; Saori Ito; Hiroki Nishikawa; Michinori Tanaka; Hiroaki Ohno; Akira Otaka; Kazuki Izumi; Eiichi Kodama; Masao Matsuoka; Nobutaka Fujii
Development of a novel fusion inhibitor against T-20-resistant HIV-1.
Advances in experimental medicine and biology 2009;611():389-91.
2009: Kenji Tomita; Tetsuo Narumi; Ayumu Niida; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii
Synthesis and application of (Z)-alkene- and (E)-fluoroalkene-dipeptide isosteres as cis-amide equivalents.
Advances in experimental medicine and biology 2009;611():365-6.
2008: Kenji Tomita; Shinya Oishi; Hiroaki Ohno; Stephen Peiper; Nobutaka Fujii
Development of novel G-protein-coupled receptor 54 agonists with resistance to degradation by matrix metalloproteinase.
Journal of medicinal chemistry 2008;51(23):7645-9.
2008: Hiroki Nishikawa; Shinya Oishi; Mizuno Fujita; Kentaro Watanabe; Rei Tokiwa; Hiroaki Ohno; Eiichi Kodama; Kazuki Izumi; Keiko Kajiwara; Takeshi Naitoh; Masao Matsuoka; Akira Otaka; Nobutaka Fujii
Identification of minimal sequence for HIV-1 fusion inhibitors.
Bioorganic & medicinal chemistry 2008;16(20):9184-7.
2008: Hiroki Iwasaki; Toru Eguchi; Nozomi Tsutsui; Hiroaki Ohno; Tetsuaki Tanaka
Samarium(II)-mediated spirocyclization by intramolecular aryl radical addition onto an aromatic ring.
The Journal of organic chemistry 2008;73(18):7145-52.
2008: Yamato Suzuki; Jérôme Cluzeau; Takafumi Hara; Akira Hirasawa; Gozoh Tsujimoto; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii
Structure-activity relationships of pyrazine-based CK2 inhibitors: synthesis and evaluation of 2,6-disubstituted pyrazines and 4,6-disubstituted pyrimidines.
Archiv der Pharmazie 2008;341(9):554-61.
2008: Akinori Okano; Tsuyoshi Mizutani; Shinya Oishi; Tetsuaki Tanaka; Hiroaki Ohno; Nobutaka Fujii
Palladium-catalysed biscyclisation of allenic bromoalkenes through a zipper-mode cascade.
Chemical communications (Cambridge, England) 2008;(30):3534-6.
2008: Satoshi Ueda; Manabu Kato; Shinsuke Inuki; Hiroaki Ohno; Barry Evans; Zixuan Wang; Stephen Peiper; Kazuki Izumi; Eiichi Kodama; Masao Matsuoka; Hideko Nagasawa; Shinya Oishi; Nobutaka Fujii
Identification of novel non-peptide CXCR4 antagonists by ligand-based design approach.
Bioorganic & medicinal chemistry letters 2008;18(14):4124-9.
2008: Eriko Inokuchi; Tetsuo Narumi; Ayumu Niida; Kazuya Kobayashi; Kenji Tomita; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii
Efficient synthesis of trifluoromethyl and related trisubstituted alkene dipeptide isosteres by palladium-catalyzed carbonylation of amino acid derived allylic carbonates.
The Journal of organic chemistry 2008;73(10):3942-5.
2008: Shinya Oishi; Ryo Masuda; Barry Evans; Satoshi Ueda; Yukiko Goto; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Zixuan Wang; Stephen Peiper; Takeshi Naito; Eiichi Kodama; Masao Matsuoka; Nobutaka Fujii
Synthesis and application of fluorescein- and biotin-labeled molecular probes for the chemokine receptor CXCR4.
Chembiochem : a European journal of chemical biology 2008;9(7):1154-8.
2008: Toshiaki Watanabe; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Palladium-catalyzed sp(3) CH activation of simple alkyl groups: direct preparation of indoline derivatives from N-alkyl-2-bromoanilines.
Organic letters 2008;10(9):1759-62.
2008: Hiroaki Ohno; Akinori Okano; S Kosaka; Koji Tsukamoto; Miyo Ohata; Kotaro Ishihara; Hatsuo Maeda; Tetsuaki Tanaka; Nobutaka Fujii
Direct construction of bicyclic heterocycles by palladium-catalyzed domino cyclization of propargyl bromides.
Organic letters 2008;10(6):1171-4.
2008: Yusuke Ohta; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation.
Chemical communications (Cambridge, England) 2008;(7):835-7.
2008: Kenji Tomita; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii
Structure-activity relationship study and NMR analysis of fluorobenzoyl pentapeptide GPR54 agonists.
Biopolymers 2008;90(4):503-11.
2007: Toshiaki Watanabe; Satoshi Ueda; Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling.
Chemical communications (Cambridge, England) 2007;(43):4516-8.
2007: Toshiaki Watanabe; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno
Gold-catalyzed hydroarylation of allenes: a highly regioselective carbon-carbon bond formation producing six-membered rings.
Organic letters 2007;9(23):4821-4.
2007: Hiroaki Ohno; Mutsumi Iuchi; Nobutaka Fujii; Tetsuaki Tanaka
Zipper-mode double C-H activation: palladium-catalyzed direct construction of highly-fused heterocyclic systems.
Organic letters 2007;9(23):4813-5.
2007: Tetsuo Narumi; Kenji Tomita; Eriko Inokuchi; Kazuya Kobayashi; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii
Facile synthesis of fluoroalkenes by palladium-catalyzed reductive defluorination of allylic gem-difluorides.
Organic letters 2007;9(17):3465-8.
2007: Kenji Tomita; Shinya Oishi; Jérôme Cluzeau; Hiroaki Ohno; Jean-Marc Navenot; Zixuan Wang; Stephen Peiper; Miki Akamatsu; Nobutaka Fujii
SAR and QSAR studies on the N-terminally acylated pentapeptide agonists for GPR54.
Journal of medicinal chemistry 2007;50(14):3222-8.
2007: Jérôme Cluzeau; Shinya Oishi; Hiroaki Ohno; Zixuan Wang; Barry Evans; Stephen Peiper; Nobutaka Fujii
Design and synthesis of all diastereomers of cyclic pseudo-dipeptides as mimics of cyclic CXCR4 pentapeptide antagonists.
Organic & biomolecular chemistry 2007;5(12):1915-23.
2007: Hiroaki Ohno; Tsuyoshi Mizutani; Yoichi Kadoh; Akimasa Aso; Kumiko Miyamura; Nobutaka Fujii; Tetsuaki Tanaka
A highly regio- and stereoselective formation of bicyclo[4.2.0]oct-5-ene derivatives through thermal intramolecular [2 + 2] cycloaddition of allenes.
The Journal of organic chemistry 2007;72(12):4378-89.
2007: Satoshi Ueda; Shinya Oishi; Zixuan Wang; Takanobu Araki; Hirokazu Tamamura; Jérôme Cluzeau; Hiroaki Ohno; Shuichi Kusano; Hideki Nakashima; John O Trent; Stephen Peiper; Nobutaka Fujii
Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities.
Journal of medicinal chemistry 2007;50(2):192-8.
2007: Hiroaki Ohno; Akimasa Aso; Yoichi Kadoh; Nobutaka Fujii; Tetsuaki Tanaka
Heck-type cyclization of oxime ethers: stereoselective carbon-carbon bond formation with aryl halides to produce heterocyclic oximes.
Angewandte Chemie (International ed. in English) 2007;46(33):6325-8.
2007: Hiroaki Ohno; Yusuke Ohta; Shinya Oishi; Nobutaka Fujii
Direct synthesis of 2-(aminomethyl)indoles through copper(I)-catalyzed domino three-component coupling and cyclization reactions.
Angewandte Chemie (International ed. in English) 2007;46(13):2295-8.
2007: Kenji Tomita; Tetsuo Narumi; Ayumu Niida; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii
Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres.
Biopolymers 2007;88(2):272-8.
2007: Hisao Hamaguchi; Shohei Kosaka; Hiroaki Ohno; Nobutaka Fujii; Tetsuaki Tanaka
Bromoallenes as allyl dication equivalents in the presence or absence of palladium(0): direct construction of bicyclic sulfamides containing five- to eight-membered rings by tandem cyclization of bromoallenes.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(6):1692-708.
2006: Tetsuo Narumi; Ayumu Niida; Kenji Tomita; Shinya Oishi; Akira Otaka; Hiroaki Ohno; Nobutaka Fujii
A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres.
Chemical communications (Cambridge, England) 2006;(45):4720-2.
2006: Kenji Tomita; Ayumu Niida; Shinya Oishi; Hiroaki Ohno; Jérôme Cluzeau; Jean-Marc Navenot; Zixuan Wang; Stephen Peiper; Nobutaka Fujii
Structure-activity relationship study on small peptidic GPR54 agonists.
Bioorganic & medicinal chemistry 2006;14(22):7595-603.
2006: Tetsuaki Tanaka; Sachiko Yamamoto; Kei Hiramatsu; Kazuo Murakami; Hitoshi Yoshino; Debasis Patra; Chuzo Iwata; Hiroaki Ohno
Construction of tricyclic enone, a common precursor for aphidicolane and stemodane B/C/D-ring system.
Chemical & pharmaceutical bulletin 2006;54(8):1138-43.
2006: Ayumu Niida; Makiko Mizumoto; Tetsuo Narumi; Eriko Inokuchi; Shinya Oishi; Hiroaki Ohno; Akira Otaka; Kazuo Kitaura; Nobutaka Fujii
Synthesis of (Z)-alkene and (E)-fluoroalkene-containing diketopiperazine mimetics utilizing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations.
The Journal of organic chemistry 2006;71(11):4118-29.
2006: Ayumu Niida; Hiroaki Tanigaki; Eriko Inokuchi; Yoshikazu Sasaki; Shinya Oishi; Hiroaki Ohno; Hirokazu Tamamura; Zixuan Wang; Stephen Peiper; Kazuo Kitaura; Akira Otaka; Nobutaka Fujii
Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-SN2' reactions and their use in the preparation of low-molecule CXCR4 antagonists.
The Journal of organic chemistry 2006;71(10):3942-51.
2006: Hiroaki Ohno; Yoichi Kadoh; Nobutaka Fujii; Tetsuaki Tanaka
Potassium carbonate-promoted stereospecific 5-endo-trig cyclization of unactivated allenes in the absence of any transition metals.
Organic letters 2006;8(5):947-50.
2005: Hiroaki Ohno
Development of useful reactions based on the novel reactivities of allenic compounds and their application to tandem cyclizations.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2005;125(12):899-925.
2005: Hiroaki Ohno
Development of useful reactions involving tandem cyclizations based on the novel reactivities of allenic compounds.
Chemical & pharmaceutical bulletin 2005;53(10):1211-26.
2005: Hiroaki Ohno; Tsuyoshi Mizutani; Yoichi Kadoh; Kumiko Miyamura; Tetsuaki Tanaka
Thermal intramolecular [2+2] cycloaddition of allenenes and allenynes: diastereoselective access to bicyclic nitrogen heterocycles.
Angewandte Chemie (International ed. in English) 2005;44(32):5113-5.
2005: Hiroaki Ohno; Mio Yamamoto; Mutsumi Iuchi; Tetsuaki Tanaka
Palladium-catalyzed tandem cyclization of bromoenynes through aromatic C-H bond functionalization.
Angewandte Chemie (International ed. in English) 2005;44(32):5103-6.
2005: Hiroaki Ohno; Kumiko Miyamura; Tsuyoshi Mizutani; Yoichi Kadoh; Yusuke Takeoka; Hisao Hamaguchi; Tetsuaki Tanaka
Palladium(0)-catalyzed tandem cyclization of allenenes: direct construction of tricyclic heterocycles through aromatic C--H activation.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(12):3728-41.
2005: Hisao Hamaguchi; Shohei Kosaka; Hiroaki Ohno; Tetsuaki Tanaka
Bromoallenes as allyl dication equivalents in the absence of palladium(0): synthesis of bicyclic sulfamides by tandem cyclization of bromoallenes.
Angewandte Chemie (International ed. in English) 2005;44(10):1513-7.
2004: Hiroaki Ohno; Hiroki Iwasaki; Toru Eguchi; Tetsuaki Tanaka
The first samarium(II)-mediated aryl radical cyclisation onto an aromatic ring.
Chemical communications (Cambridge, England) 2004;(19):2228-9.
2004: Kyoko Hayashi; S M Abdur Rahman; Hiroaki Ohno; Tetsuaki Tanaka; Naoki Toyooka; Hideo Nemoto; Toshimitsu Hayashi
Evaluation of scopadulciol-related molecules for their stimulatory effect on the cytotoxicity of acyclovir and ganciclovir against Herpes simplex virus type 1 thymidine kinase gene-transfected HeLa cells.
Chemical & pharmaceutical bulletin 2004;52(8):1015-7.
2004: Hiroaki Ohno; Hisao Hamaguchi; Miyo Ohata; Shohei Kosaka; Tetsuaki Tanaka
Palladium(0)-catalyzed synthesis of medium-sized heterocycles by using bromoallenes as an allyl dication equivalent.
Journal of the American Chemical Society 2004;126(28):8744-54.
2004: Hiroaki Ohno; Yusuke Takeoka; Yoichi Kadoh; Kumiko Miyamura; Tetsuaki Tanaka
Palladium(0)-catalyzed stereoselective cyclization of allenenes: divergent synthesis of pyrrolidines and 3-azabicyclo[3.1.0]hexanes from single allenenes.
The Journal of organic chemistry 2004;69(13):4541-4.
2004: Hiroaki Ohno; Yoshiji Takemoto; Nobutaka Fujii; Tetsuaki Tanaka; Toshiro Ibuka
Stereodivergent synthesis of chiral 2-alkenylaziridines: palladium(0)-catalyzed 2,3-cis-selective aziridination and base-mediated 2,3-trans-selective aziridination.
Chemical & pharmaceutical bulletin 2004;52(1):111-9.
2003: Hiroaki Ohno; Yusuke Takeoka; Kumiko Miyamura; Yoichi Kadoh; Tetsuaki Tanaka
Novel synthesis of 3-azabicyclo[3.1.0]hexanes by unusual palladium(0)-catalyzed cyclopropanation of allenenes.
Organic letters 2003;5(25):4763-6.
2003: Hiroaki Ohno; Mitsuaki Okumura; Shin-ichiro Maeda; Hiroki Iwasaki; Ryutaro Wakayama; Tetsuaki Tanaka
Samarium(II)-promoted radical spirocyclization onto an aromatic ring.
The Journal of organic chemistry 2003;68(20):7722-32.
2003: Hiroaki Ohno; Ryutaro Wakayama; Shin-ichiro Maeda; Hiroki Iwasaki; Mitsuaki Okumura; Chuzo Iwata; Hidenori Mikamiyama; Tetsuaki Tanaka
Radical cyclization by ipso substitution of the methoxy group: considerable effect of HMPA on samarium-mediated cyclization.
The Journal of organic chemistry 2003;68(15):5909-16.
2003: Hiroaki Ohno; Kumiko Miyamura; Yusuke Takeoka; Tetsuaki Tanaka
Palladium(0)-catalyzed tandem cyclization of allenenes.
Angewandte Chemie (International ed. in English) 2003;42(23):2647-50.
2003: Hiroaki Ohno; Hisao Hamaguchi; Miyo Ohata; Tetsuaki Tanaka
Bromoallenes as synthetic equivalents of allyl dications: synthesis of medium-sized nitrogen heterocycles through the cyclization of bromoallenes in the presence of a palladium(0) catalyst and an alcohol.
Angewandte Chemie (International ed. in English) 2003;42(15):1749-53.
2002: Hiroaki Ohno; Kaori Ando; Hisao Hamaguchi; Yusuke Takeoka; Tetsuaki Tanaka
A highly cis-selective synthesis of 2-ethynylaziridines by intramolecular amination of chiral bromoallenes: improvement of stereoselectivity based on the computational investigation.
Journal of the American Chemical Society 2002;124(51):15255-66.
2002: Hiroaki Ohno; Kumiko Miyamura; Tetsuaki Tanaka; Shinya Oishi; Ayako Toda; Yoshiji Takemoto; Nobutaka Fujii; Toshiro Ibuka
Synthesis of allenes from allylic alcohol derivatives bearing a bromine atom using a palladium(0)/diethylzinc system.
The Journal of organic chemistry 2002;67(4):1359-67.
2002: Hiroaki Ohno; Shin-ichiro Maeda; Mitsuaki Okumura; Ryutaro Wakayama; Tetsuaki Tanaka
The first samarium(II)-mediated stereoselective spirocyclization onto an aromatic ring.
Chemical communications (Cambridge, England) 2002;(4):316-7.
2001: Tetsuaki Tanaka; Kazuo Murakami; A Kanda; Debasis Patra; S Yamamoto; N Satoh; S W Kim; S M Abdur Rahman; Hiroaki Ohno; Chuzo Iwata
Total synthesis of (+/-)-stemodinone via an efficient ring-exchange strategy.
The Journal of organic chemistry 2001;66(21):7107-12.
2001: Hiroaki Ohno
[Development of aziridination and azetizination reactions of amino allenes using a palladium catalyst].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2001;121(10):733-41.
2001: Hiroaki Ohno; Hisao Hamaguchi; Tetsuaki Tanaka
Stereoselective synthesis of chiral 2,3-cis-2-ethynylaziridines by base-mediated intramolecular amination of bromoallenes.
Organic letters 2001;3(15):2269-71.
2001: Hiroaki Ohno; M Anzai; A Toda; Sachiko Ohishi; Nobutaka Fujii; Tetsuaki Tanaka; Yoshiji Takemoto; Toshiro Ibuka
Stereoselective synthesis of 2-alkenylaziridines and 2-alkenylazetidines by palladium-catalyzed intramolecular amination of alpha- and beta-amino allenes.
The Journal of organic chemistry 2001;66(14):4904-14.
2001: S M Abdur Rahman; Hiroaki Ohno; Tsuyoshi Murata; Hitoshi Yoshino; N Satoh; Kazuo Murakami; Debasis Patra; Chuzo Iwata; Naoyoshi Maezaki; Tetsuaki Tanaka
Total synthesis of (+/-)-scopadulin.
The Journal of organic chemistry 2001;66(14):4831-40.
2001: Hiroaki Ohno; H Hamaguchi; Tetsuaki Tanaka
2-ethynylaziridines as chiral carbon nucleophiles: stereoselective synthesis of 1,3-amino alcohols with three stereocenters via allenylindium reagents bearing a protected amino group.
The Journal of organic chemistry 2001;66(5):1867-75.
2001: S M Abdur Rahman; Hiroaki Ohno; Tsuyoshi Murata; Hitoshi Yoshino; N Satoh; Kazuo Murakami; Debasis Patra; Chuzo Iwata; Naoyoshi Maezaki; Tetsuaki Tanaka
The first total synthesis of (+/-)-scopadulin, an antiviral aphidicolane diterpene.
Organic letters 2001;3(4):619-21.
2000: S M Abdur Rahman; Hiroaki Ohno; Naoyoshi Maezaki; Chuzo Iwata; Tetsuaki Tanaka
Efficient one-step conversion of primary aliphatic amines into primary alcohols: application to a model study for the total synthesis of (+/-)-scopadulin.
Organic letters 2000;2(18):2893-5.