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Seiichiroh Ohsako

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Hisaka Kurita; Seiichiroh Ohsako; Shin-ichi Hashimoto; Jun Yoshinaga; Chiharu Tohyama
Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene.
Xian-Yang Qin; Hiromi Akanuma; Satoshi Imanishi; Reiko Nagano; Seiichiroh Ohsako; Masaru Tanokura; Feifei Wei; Junzo Yonemoto; Jun Yoshinaga; Qin Zeng; Hideko Sone
Effect of low-dose thalidomide on dopaminergic neuronal differentiation of human neural progenitor cells: a combined study of metabolomics and morphological analysis.
Xiaoming He; Satoshi Imanishi; R Nagano; Xian-Yang Qin; Hideko Sone; Junko Yamane; Jun Yoshinaga; Hiromi Akanuma; Wataru Fujibuchi; Seiichiroh Ohsako
Effects of methylmercury exposure on neuronal differentiation of mouse and human embryonic stem cells.

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2013: Hisaka Kurita; Seiichiroh Ohsako; Shin-ichi Hashimoto; Jun Yoshinaga; Chiharu Tohyama
Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene.
The Journal of nutritional biochemistry 2013;24(1):256-66.
2012: Xian-Yang Qin; Hiromi Akanuma; Satoshi Imanishi; Reiko Nagano; Seiichiroh Ohsako; Masaru Tanokura; Feifei Wei; Junzo Yonemoto; Jun Yoshinaga; Qin Zeng; Hideko Sone
Effect of low-dose thalidomide on dopaminergic neuronal differentiation of human neural progenitor cells: a combined study of metabolomics and morphological analysis.
Neurotoxicology 2012;33(5):1375-80.
2012: Xiaoming He; Satoshi Imanishi; R Nagano; Xian-Yang Qin; Hideko Sone; Junko Yamane; Jun Yoshinaga; Hiromi Akanuma; Wataru Fujibuchi; Seiichiroh Ohsako
Effects of methylmercury exposure on neuronal differentiation of mouse and human embryonic stem cells.
Toxicology letters 2012;212(1):1-10.
2012: Wataru Yoshioka; Satoshi Uematsu; Keiko Aida-Yasuoka; Shizuo Akira; Nozomi Fujisawa; Shuntaro Hara; Tatsuya Kawaguchi; Seiichiroh Ohsako; Chiharu Tohyama
Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(2):547-54.
2012: Hiromi Akanuma; Tomokazu Fukuda; Satoshi Imanishi; R Nagano; Seiichiroh Ohsako; Xian-Yang Qin; Tin-Tin Win-Shwe; Jun Yoshinaga; Hiroko Zaha; Hideko Sone
Identification of Stage-Specific Gene Expression Signatures in Response to Retinoic Acid during the Neural Differentiation of Mouse Embryonic Stem Cells.
Frontiers in genetics 2012;3():141.
2012: Reiko Nagano; Seiichiroh Ohsako; Xian-Yang Qin; Hiromi Akanuma; Satoshi Imanishi; Hiroyoshi Toyoshiba; Jun Yoshinaga; Hideko Sone
Multi-parametric profiling network based on gene expression and phenotype data: a novel approach to developmental neurotoxicity testing.
International journal of molecular sciences 2012;13(1):187-207.
2010: M S Alam; Seiichiroh Ohsako; Tat Wei Tay; Naoki Tsunekawa; Yoshiakira Kanai; Masamichi Kurohmaru
Di(n-butyl) phthalate induces vimentin filaments disruption in rat sertoli cells: a possible relation with spermatogenic cell apoptosis.
Anatomia, histologia, embryologia 2010;39(3):186-93.
2010: Seiichiroh Ohsako; Noriho Fukuzawa; Ryuta Ishimura; Takashige Kawakami; Qing Wu; Reiko Nagano; Hiroko Zaha; Hideko Sone; Junzo Yonemoto; Chiharu Tohyama
Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.
Biology of reproduction 2010;82(3):636-43.
2010: Hideko Sone; Masahiro Okura; Hiroko Zaha; Wataru Fujibuchi; Takeaki Taniguchi; Hiromi Akanuma; R Nagano; Seiichiroh Ohsako; Junzo Yonemoto
Profiles of Chemical Effects on Cells (pCEC): a toxicogenomics database with a toxicoinformatics system for risk evaluation and toxicity prediction of environmental chemicals.
The Journal of toxicological sciences 2010;35(1):115-23.
2010: Mohammad Shah Alam; Seiichiroh Ohsako; Takashi Matsuwaki; Xiao Bo Zhu; Naoki Tsunekawa; Yoshiakira Kanai; Hideko Sone; Chiharu Tohyama; Masamichi Kurohmaru
Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effect of di(n-butyl) phthalate.
Reproduction (Cambridge, England) 2010;139(2):427-37.
2010: Kana Ishihara; Seiichiroh Ohsako; Ken Tasaka; Hiroshi Harayama; Masashi Miyake; Katsuhiko Warita; Takashi Tanida; Tomoko Mitsuhashi; Takashi Nanmori; Y Tabuchi; Toshifumi Yokoyama; Hiroshi Kitagawa; Nobuhiko Hoshi
When does the sex ratio of offspring of the paternal 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure decrease: in the spermatozoa stage or at fertilization?
Reproductive toxicology (Elmsford, N.Y.) 2010;29(1):68-73.
2009: Takashige Kawakami; Tomohiro Ito; Seiichiroh Ohsako; Kazuhiro Shiizaki; Yoshitaka Murakami; Kazunari Hirowatari; Masao Sato; Chiharu Tohyama
Possible involvement of arylhydrocarbon receptor variants in TCDD-induced thymic atrophy and XRE-dependent transcriptional activity in Wistar Hannover GALAS rats.
The Journal of toxicological sciences 2009;34(2):209-20.
2009: Ryuta Ishimura; Takashige Kawakami; Seiichiroh Ohsako; Chiharu Tohyama
Dioxin-induced toxicity on vascular remodeling of the placenta.
Biochemical pharmacology 2009;77(4):660-9.
2008: Kazuhiro Shiizaki; Seiichiroh Ohsako; Masanobu Kawanishi; Takashi Yagi
Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYP1A1 activity in human and mouse hepatoma cells.
Basic & clinical pharmacology & toxicology 2008;103(5):468-75.
2008: Qing Wu; Junko S Suzuki; Hiroko Zaha; Tien-Min Lin; Richard E Peterson; Chiharu Tohyama; Seiichiroh Ohsako
Differences in gene expression and benzo[a]pyrene-induced DNA adduct formation in the liver of three strains of female mice with identical AhRb2 genotype treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and/or benzo[a]pyrene.
Journal of applied toxicology : JAT 2008;28(6):724-33.
2007: Yoshinori Sakata; Wataru Yoshioka; Chiharu Tohyama; Seiichiroh Ohsako
Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide.
Biochemical and biophysical research communications 2007;355(3):687-92.
2006: Ryuta Ishimura; Takashige Kawakami; Seiichiroh Ohsako; Keiko Nohara; Chiharu Tohyama
Suppressive effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vascular remodeling that takes place in the normal labyrinth zone of rat placenta during late gestation.
Toxicological sciences : an official journal of the Society of Toxicology 2006;91(1):265-74.
2006: Takashige Kawakami; Ryuta Ishimura; Keiko Nohara; Ken Takeda; Chiharu Tohyama; Seiichiroh Ohsako
Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor.
Toxicology and applied pharmacology 2006;212(3):224-36.
2005: Kazuhiro Shiizaki; Seiichiroh Ohsako; Toshie Koyama; Ryoichi Nagata; Junzo Yonemoto; Chiharu Tohyama
Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin.
Toxicology letters 2005;160(1):22-33.
2005: Seiichiroh Ohsako; Chiharu Tohyama
Comparison of study controls.
Environmental health perspectives 2005;113(9):A582; author reply A582-3.
2004: Noriho H Fukuzawa; Seiichiroh Ohsako; Qing Wu; Motoharu Sakaue; Yoshiaki Fujii-Kuriyama; Tadashi Baba; Chiharu Tohyama
Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse.
Molecular and cellular endocrinology 2004;221(1-2):87-96.
2004: Qing Wu; Seiichiroh Ohsako; Ryuta Ishimura; Junko S Suzuki; Chiharu Tohyama
Exposure of mouse preimplantation embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2.
Biology of reproduction 2004;70(6):1790-7.
2003: Kunihiro Kubota; Seiichiroh Ohsako; Shuichi Kurosawa; Ken Takeda; Wu Qing; Motoharu Sakaue; Takashige Kawakami; Ryuta Ishimura; Chiharu Tohyama
Effects of vinclozolin administration on sperm production and testosterone biosynthetic pathway in adult male rat.
The Journal of reproduction and development 2003;49(5):403-12.
2003: Seiichiroh Ohsako; Kunihiro Kubota; Shuichi Kurosawa; Ken Takeda; Wu Qing; Ryuta Ishimura; Chiharu Tohyama
Alterations of gene expression in adult male rat testis and pituitary shortly after subacute administration of the antiandrogen flutamide.
The Journal of reproduction and development 2003;49(4):275-90.
2003: Myung Chan Gye; Seiichiroh Ohsako
Effects of flutamide in the rat testis on the expression of occludin, an integral member of the tight junctions.
Toxicology letters 2003;143(2):217-22.
2003: Noriho H Fukuzawa; Seiichiroh Ohsako; R Nagano; Motoharu Sakaue; T Baba; Yasunobu Aoki; Chiharu Tohyama
Effects of 3,3',4,4',5-pentachlorobiphenyl, a coplanar polychlorinated biphenyl congener, on cultured neonatal mouse testis.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(3):259-69.
2003: Takashi Moriguchi; Hozumi Motohashi; Tomonori Hosoya; Osamu Nakajima; Satoru Takahashi; Seiichiroh Ohsako; Yasunobu Aoki; Noriko Nishimura; Chiharu Tohyama; Yoshiaki Fujii-Kuriyama; Masayuki Yamamoto
Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5652-7.
2002: Ryuta Ishimura; Seiichiroh Ohsako; Takashige Kawakami; Motoharu Sakaue; Yasunobu Aoki; Chiharu Tohyama
Altered protein profile and possible hypoxia in the placenta of 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed rats.
Toxicology and applied pharmacology 2002;185(3):197-206.
2002: Qing Wu; Seiichiroh Ohsako; Tadashi Baba; Kyoko Miyamoto; Chiharu Tohyama
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on preimplantation mouse embryos.
Toxicology 2002;174(2):119-29.
2002: Seiichiroh Ohsako; Yuichi Miyabara; Motoharu Sakaue; Ryuta Ishimura; Masaki Kakeyama; Hiroyuki Izumi; Junzo Yonemoto; Chiharu Tohyama
Developmental stage-specific effects of perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on reproductive organs of male rat offspring.
Toxicological sciences : an official journal of the Society of Toxicology 2002;66(2):283-92.
2002: Motoharu Sakaue; Ryuta Ishimura; Shuichi Kurosawa; Noriho H Fukuzawa; Masamichi Kurohmaru; Yoshihiro Hayashi; Chiharu Tohyama; Seiichiroh Ohsako
Administration of estradiol-3-benzoate down-regulates the expression of testicular steroidogenic enzyme genes for testosterone production in the adult rat.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2002;64(2):107-13.
2002: Ryuta Ishimura; Seiichiroh Ohsako; Yuichi Miyabara; Motoharu Sakaue; Takashige Kawakami; Yasunobu Aoki; Junzo Yonemoto; Chiharu Tohyama
Increased glycogen content and glucose transporter 3 mRNA level in the placenta of Holtzman rats after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicology and applied pharmacology 2002;178(3):161-71.
2001: Seiichiroh Ohsako; Yuichi Miyabara; Noriko Nishimura; S Kurosawa; Motoharu Sakaue; Ryuta Ishimura; Mikio Sato; Ken Takeda; Yasunobu Aoki; Hideko Sone; Chiharu Tohyama; Junzo Yonemoto
Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose-dependent increase of mRNA levels of 5alpha-reductase type 2 in contrast to decrease of androgen receptor in the pubertal ventral prostate.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(1):132-43.
2000: C Tohyama; Seiichiroh Ohsako; Ryuta Ishimura
[Health risk assessment of endocrine disrupting chemicals].
Nihon rinsho. Japanese journal of clinical medicine 2000;58(12):2393-400.
2000: R Nagano; S Tabata; Y Nakanishi; Seiichiroh Ohsako; Masamichi Kurohmaru; Yasuhide Hayashi
Reproliferation and relocation of mouse male germ cells (gonocytes) during prespermatogenesis.
The Anatomical record 2000;258(2):210-20.
1999: Yoshikazu Sugimoto; S Sanuki; Seiichiroh Ohsako; Y Higashimoto; M Kondo; Junichi Kurawaki; Hisham R Ibrahim; Takayoshi Aoki; T Kusakabe; K Koga
Ovalbumin in developing chicken eggs migrates from egg white to embryonic organs while changing its conformation and thermal stability.
The Journal of biological chemistry 1999;274(16):11030-7.
1998: Hideki Endo; Masamichi Kurohmaru; Yasuhide Hayashi; Seiichiroh Ohsako; M Matsumoto; Hayao Nishinakagawa; H Yamamoto; Y Kurosawa; Kazuaki Tanaka
Multivariate analysis of mandible in the Ryukyu wild pig (Sus scrofa riukiuanus).
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1998;60(6):731-3.
1998: Y Toyoshima; Seiichiroh Ohsako; R Nagano; Mitsuharu Matsumoto; S Hidaka; Hayao Nishinakagawa
Histological changes in mouse nipple tissue during the reproductive cycle.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1998;60(4):405-11.
1998: S Hidaka; Mitsuharu Matsumoto; Seiichiroh Ohsako; Y Toyoshima; Hayao Nishinakagawa
A histometrical study on the long bones of raccoon dogs, Nyctereutes procyonoides and badgers, Meles meles.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1998;60(3):323-6.
1998: S Hidaka; Mitsuharu Matsumoto; H Hiji; Seiichiroh Ohsako; Hayao Nishinakagawa
Morphology and morphometry of skulls of raccoon dogs, Nyctereutes procyonoides and badgers, Meles meles.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1998;60(2):161-7.
1998: Y Toyoshima; Seiichiroh Ohsako; Mitsuharu Matsumoto; S Hidaka; Hayao Nishinakagawa
Histological and morphometrical studies on the rat nipple during the reproductive cycle.
Experimental animals / Japanese Association for Laboratory Animal Science 1998;47(1):29-36.
1997: Seiichiroh Ohsako; R Nagano; Y Sugimoto; K Goto
Comparison of the nuclear DNA stability against freezing-thawing and high temperature treatments between spermatozoa and somatic cells.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1997;59(11):1085-8.
1995: Seiichiroh Ohsako; David Bunick; Y Hayashi
Immunocytochemical observation of the 90 KD heat shock protein (HSP90): high expression in primordial and pre-meiotic germ cells of male and female rat gonads.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(1):67-76.
1994: Seiichiroh Ohsako; Y Hayashi; David Bunick
Molecular cloning and sequencing of calnexin-t. An abundant male germ cell-specific calcium-binding protein of the endoplasmic reticulum.
The Journal of biological chemistry 1994;269(19):14140-8.
1994: Seiichiroh Ohsako; David Bunick; Rex Allen Hess; Takao Nishida; Masamichi Kurohmaru; Y Hayashi
Characterization of a testis specific protein localized to endoplasmic reticulum of spermatogenic cells.
The Anatomical record 1994;238(3):335-48.
1991: Seiichiroh Ohsako; Masamichi Kurohmaru; Takao Nishida; Y Hayashi
Analysis of various antigens in golden hamster testis by monoclonal antibodies.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1991;53(6):969-74.