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Tomihisa Ohta

Research Profile

Chemicals & Drugs

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Anatomy

Phenomena

Magnetic Resonance Spectroscopy

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Marine Biology

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Publications

TOP 3
Kaoru Mitani; Ahmed E Allam; Shinji Fushiya; Tetsuro Kawabata; Mayumi Ota; Chikai Sakurada; Tomoya Takahashi; Fumihide Takano; Nobuo Yahagi; Tomihisa Ohta
Suppression of melanin synthesis by the phenolic constituents of sappanwood (Caesalpinia sappan).
Maorong Suo; Fumihide Takano; Hasegawa Isao; Hikaru Kato; Tomihisa Ohta
Anti-inflammatory constituents from Tabebuia avellanedae.
Ahmed E Allam; Enaam Y Backheet; Mohamed A El-Shanawany; Alaa M Nafady; Fumihide Takano; Tomihisa Ohta
Two new acetylated flavonoid glycosides from Centaurium spicatum L.

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All Publications

2013: Kaoru Mitani; Ahmed E Allam; Shinji Fushiya; Tetsuro Kawabata; Mayumi Ota; Chikai Sakurada; Tomoya Takahashi; Fumihide Takano; Nobuo Yahagi; Tomihisa Ohta
Suppression of melanin synthesis by the phenolic constituents of sappanwood (Caesalpinia sappan).
Planta medica 2013;79(1):37-44.
2012: Maorong Suo; Fumihide Takano; Hasegawa Isao; Hikaru Kato; Tomihisa Ohta
Anti-inflammatory constituents from Tabebuia avellanedae.
Fitoterapia 2012;83(8):1484-8.
2012: Ahmed E Allam; Enaam Y Backheet; Mohamed A El-Shanawany; Alaa M Nafady; Fumihide Takano; Tomihisa Ohta
Two new acetylated flavonoid glycosides from Centaurium spicatum L.
Journal of natural medicines 2012;66(2):388-93.
2012: Takanori Tatsuno; Nobuo Yahagi; Fumihide Takano; Yukiko Arima; Tatsuya Hasegawa; Megumi Jinno; Tetsuro Kawabata; Tomihisa Ohta
Anti-inflammatory and anti-melanogenic proanthocyanidin oligomers from peanut skin.
Biological & pharmaceutical bulletin 2012;35(6):909-16.
2012: Maorong Suo; Fumihide Takano; Yasoku Shimano; Changxiao Bi; Hasegawa Isao; Yoshihiro Ishida; Hikaru Kato; Tomihisa Ohta
Phenolic lipid ingredients from cashew nuts.
Journal of natural medicines 2012;66(1):133-9.
2011: Hikaru Kato; Ryosuke Kawabata; Masayuki Samizo; Fumihide Takano; Tomihisa Ohta
Stilbenoids from the melinjo (Gnetum gnemon L.) fruit modulate cytokine production in murine Peyer's patch cells ex vivo.
Planta medica 2011;77(10):1027-34.
2011: Tetsuro Kawabata; Ming-Yue Cui; Tatsuya Hasegawa; Fumihide Takano; Tomihisa Ohta
Anti-inflammatory and anti-melanogenic steroidal saponin glycosides from Fenugreek (Trigonella foenum-graecum L.) seeds.
Planta medica 2011;77(7):705-10.
2010: Masaya Yamaguchi; Isao Hasegawa; Nobuo Yahagi; Yasuhito Ishigaki; Fumihide Takano; Tomihisa Ohta
Carotenoids modulate cytokine production in Peyer's patch cells ex vivo.
Journal of agricultural and food chemistry 2010;58(15):8566-72.
2009: Fumihide Takano; Yasuyuki Ohta; Tomoaki Tanaka; Kenroh Sasaki; K i Kobayashi; Tomoya Takahashi; Nobuo Yahagi; Fumihiko Yoshizaki; Shinji Fushiya; Tomihisa Ohta
Oral Administration of Ren-Shen-Yang-Rong-Tang 'Ninjin'yoeito' Protects Against Hematotoxicity and Induces Immature Erythroid Progenitor Cells in 5-Fluorouracil-induced Anemia.
Evidence-based complementary and alternative medicine : eCAM 2009;6(2):247-56.
2009: Sachiko Tsukamoto; Hikaru Kato; Thomas J Greshock; Hiroshi Hirota; Tomihisa Ohta; Robert M Williams
Isolation of notoamide E, a key precursor in the biosynthesis of prenylated indole alkaloids in a marine-derived fungus, Aspergillus sp.
Journal of the American Chemical Society 2009;131(11):3834-5.
2009: Sachiko Tsukamoto; Tetsuro Kawabata; Hikaru Kato; Thomas J Greshock; Hiroshi Hirota; Tomihisa Ohta; Robert M Williams
Isolation of antipodal (-)-versicolamide B and notoamides L-N from a marine-derived Aspergillus sp.
Organic letters 2009;11(6):1297-300.
2008: Sachiko Tsukamoto; Tomoharu Takeuchi; Henki Rotinsulu; Remy E P Mangindaan; Rob W M van Soest; Kazuyo Ukai; Hisayoshi Kobayashi; Michio Namikoshi; Tomihisa Ohta; Hideyoshi Yokosawa
Leucettamol A: a new inhibitor of Ubc13-Uev1A interaction isolated from a marine sponge, Leucetta aff. microrhaphis.
Bioorganic & medicinal chemistry letters 2008;18(24):6319-20.
2008: Sachiko Tsukamoto; Hikaru Kato; Masayuki Samizo; Yuka Nojiri; Hiroyuki Onuki; Hiroshi Hirota; Tomihisa Ohta
Notoamides F-K, prenylated indole alkaloids isolated from a marine-derived Aspergillus sp.
Journal of natural products 2008;71(12):2064-7.
2008: Takanobu Takata; Tomoaki Tanaka; Nobuo Yahagi; Remiko Yahagi; Hideyuki Tsuchida; Yasuhito Ishigaki; Naohisa Tomosugi; Shinji Fushiya; Fumihide Takano; Tomihisa Ohta
The liquid culture filtrates of entomogenous fungus Paecilomyces tenuipes and its glycoprotein constituent protects against anemia in mice treated with 5-fluorouracil.
Biological & pharmaceutical bulletin 2008;31(8):1565-73.
2008: Tatsuya Hasegawa; Ayumi Tanaka; Akiko Hosoda; Fumihide Takano; Tomihisa Ohta
Antioxidant C-glycosyl flavones from the leaves of Sasa kurilensis var. gigantea.
Phytochemistry 2008;69(6):1419-24.
2008: Tatsuya Hasegawa; Fumihide Takano; Takanobu Takata; Masato Niiyama; Tomihisa Ohta
Bioactive monoterpene glycosides conjugated with gallic acid from the leaves of Eucalyptus globulus.
Phytochemistry 2008;69(3):747-53.
2007: Tatsuya Hasegawa; Mayumi Ishibashi; Takanobu Takata; Fumihide Takano; Tomihisa Ohta
Cytotoxic fatty acid from Pleurocybella porrigens.
Chemical & pharmaceutical bulletin 2007;55(12):1748-9.
2007: Sachiko Tsukamoto; Tetsuro Kawabata; Hikaru Kato; Tomihisa Ohta; Henki Rotinsulu; Remy E P Mangindaan; Rob W M van Soest; Kazuyo Ukai; Hisayoshi Kobayashi; Michio Namikoshi
Naamidines H and I, cytotoxic imidazole alkaloids from the Indonesian marine sponge Leucetta chagosensis.
Journal of natural products 2007;70(10):1658-60.
2007: Ahmed Atef El-Beih; Tetsuro Kawabata; Keiichiro Koimaru; Tomihisa Ohta; Sachiko Tsukamoto
Monodictyquinone A: a new antimicrobial anthraquinone from a sea urchin-derived fungus Monodictys sp.
Chemical & pharmaceutical bulletin 2007;55(7):1097-8.
2007: Ahmed Atef El-Beih; Hikaru Kato; Tomihisa Ohta; Sachiko Tsukamoto
(3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin: a new ramulosin derivative from a marine-derived sterile mycelium.
Chemical & pharmaceutical bulletin 2007;55(6):953-4.
2007: Fumihide Takano; Takanobu Takata; Akio Yoshihara; Yuka Nakamura; Yukiko Arima; Tomihisa Ohta
Aqueous extract of peanut skin and its main constituent procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin.
Biological & pharmaceutical bulletin 2007;30(5):922-7.
2007: Fumihide Takano; Masaya Yamaguchi; Satoko Takada; Satoko Shoda; Nobuo Yahagi; Tomoya Takahashi; Tomihisa Ohta
Capsicum ethanol extracts and capsaicin enhance interleukin-2 and interferon-gamma production in cultured murine Peyer's patch cells ex vivo.
Life sciences 2007;80(17):1553-63.
2007: Hikaru Kato; Takushi Yoshida; Takanori Tokue; Yuka Nojiri; Hiroshi Hirota; Tomihisa Ohta; Robert M Williams; Sachiko Tsukamoto
Notoamides A-D: prenylated indole alkaloids isolated from a marine-derived fungus, Aspergillus sp.
Angewandte Chemie (International ed. in English) 2007;46(13):2254-6.
2006: Sachiko Tsukamoto; Takushi Yoshida; Hidetaka Hosono; Tomihisa Ohta; Hideyoshi Yokosawa
Hexylitaconic acid: a new inhibitor of p53-HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp.
Bioorganic & medicinal chemistry letters 2006;16(1):69-71.
2005: Sachiko Tsukamoto; Maki Aburatani; Tomohiro Yoshida; Yuko Yamashita; Ahmed Atef El-Beih; Tomihisa Ohta
CYP3A4 inhibitors isolated from Licorice.
Biological & pharmaceutical bulletin 2005;28(10):2000-2.
2005: Sachiko Tsukamoto; Takeshi Wakana; Keiichirou Koimaru; Takushi Yoshida; Mako Sato; Tomihisa Ohta
7-hydroxy-3-(4-hydroxybenzyl)chroman and broussonin b: neurotrophic compounds, isolated from Anemarrhena asphodeloides BUNGE, function as proteasome inhibitors.
Biological & pharmaceutical bulletin 2005;28(9):1798-800.
2005: Fumihide Takano; Nobuo Yahagi; Remiko Yahagi; Satoko Takada; Masaya Yamaguchi; Satoko Shoda; Takeshi Murase; Shinji Fushiya; Tomihisa Ohta
The liquid culture filtrates of Paecilomyces tenuipes (Peck) Samson (=Isaria japonica Yasuda) and Paecilomyces cicadae (Miquel) Samson (=Isaria sinclairii (Berk.) Llond) regulate Th1 and Th2 cytokine response in murine Peyer's patch cells in vitro and ex vivo.
International immunopharmacology 2005;5(5):903-16.
2005: Sachiko Tsukamoto; Hiroshi Hirota; Misako Imachi; Masahiro Fujimuro; Hiroyuki Onuki; Tomihisa Ohta; Hideyoshi Yokosawa
Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.
Bioorganic & medicinal chemistry letters 2005;15(1):191-4.
2004: Sachiko Tsukamoto; Kyoko Tomise; Maki Aburatani; Hiroyuki Onuki; Hiroshi Hirorta; Eiji Ishiharajima; Tomihisa Ohta
Isolation of cytochrome P450 inhibitors from strawberry fruit, Fragaria ananassa.
Journal of natural products 2004;67(11):1839-41.
2004: Shinzo Hosoi; Jun Serata; Fumiyuki Kiuchi; Akiyo Sakushima; Tomihisa Ohta
Advanced method for assignment of absolute configuration utilizing an induced CD and computational technique: its application to natural products possessing a secondary alcohol.
Journal of natural products 2004;67(9):1568-70.
2004: Sachiko Tsukamoto; Katsumi Yamashita; Kazuhiro Tane; Ryoichi Kizu; Tomihisa Ohta; Shigeki Matsunaga; Nobuhiro Fusetani; Hiroyuki Kawahara; Hideyoshi Yokosawa
Girolline, an antitumor compound isolated from a sponge, induces G2/M cell cycle arrest and accumulation of polyubiquitinated p53.
Biological & pharmaceutical bulletin 2004;27(5):699-701.
2004: Sachiko Tsukamoto; Shunsuke Miura; Yuko Yamashita; Tomihisa Ohta
Aspermytin A: a new neurotrophic polyketide isolated from a marine-derived fungus of the genus Aspergillus.
Bioorganic & medicinal chemistry letters 2004;14(2):417-20.
2004: Nobutaka Suzuki; Satoshi Ohno; Tsutomu Kamei; Yumiko Yoshiki; Yuji Kikuchi; Kazuyoshi Okubo; Tomihisa Ohta; Shoji Shimizu; Saburo Koshimura; Atsufumi Taru; Masaki Inoue
Complementary and alternative medicine in Japan.
Advances in experimental medicine and biology 2004;546():9-25.
2003: Sachiko Tsukamoto; Abdulgafor D Macabalang; Keigo Nakatani; Yutaro Obara; Norimichi Nakahata; Tomihisa Ohta
Tricholomalides A-C, new neurotrophic diterpenes from the mushroom Tricholoma sp.
Journal of natural products 2003;66(12):1578-81.
2003: Sachiko Tsukamoto; Mayu Tatsuno; Rob W M van Soest; Hideyoshi Yokosawa; Tomihisa Ohta
New polyhydroxy sterols: proteasome inhibitors from a marine sponge Acanthodendrilla sp.
Journal of natural products 2003;66(9):1181-5.
2003: Sachiko Tsukamoto; Shunsuke Miura; Rob W M van Soest; Tomihisa Ohta
Three new cytotoxic sesterterpenes from a marine sponge Spongia sp.
Journal of natural products 2003;66(3):438-40.
2002: Sachiko Tsukamoto; Kyoko Tomise; Keiko Miyakawa; Bae-Cheon Cha; Takamasa Abe; Toshiyuki Hamada; Hiroshi Hirota; Tomihisa Ohta
CYP3A4 inhibitory activity of new bisalkaloids, dipiperamides D and E, and cognates from white pepper.
Bioorganic & medicinal chemistry 2002;10(9):2981-5.
2002: Tomihisa Ohta; Minoru Nagahashi; Shinzo Hosoi; Sachiko Tsukamoto
Dihydroxybergamottin caproate as a potent and stable CYP3A4 inhibitor.
Bioorganic & medicinal chemistry 2002;10(4):969-73.
2001: Sachiko Tsukamoto; Kazuhiro Tane; Tomihisa Ohta; S Matsunaga; Nobuhiro Fusetani; Rob W M van Soest
Four new bioactive pyrrole-derived alkaloids from the marine sponge Axinella brevistyla.
Journal of natural products 2001;64(12):1576-8.
2001: Shinzo Hosoi; M Kamiya; Tomihisa Ohta
Novel development of exciton-coupled circular dichroism based on induced axial chirality.
Organic letters 2001;3(23):3659-62.