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Toshiyuki Ohtsuka

Research Profile

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Yukiko Harima; Toshiyuki Ohtsuka; Yoshiki Takashima; Yuriko Ueda; Ryoichiro Kageyama
Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene.
Siok-Lay Tan; Toshiyuki Ohtsuka; Aitor González; Ryoichiro Kageyama
MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain.
Siok-Lay Tan; Hiroyuki Aburatani; Asuka Kamio-Miura; Toshiyuki Matsui; Miyuki Nishi; Toshiyuki Ohtsuka; Yoichi Shinkai; Keiko Takemoto; Ryoichiro Kageyama
Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development.

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2013: Yukiko Harima; Toshiyuki Ohtsuka; Yoshiki Takashima; Yuriko Ueda; Ryoichiro Kageyama
Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene.
Cell reports 2013;3(1):1-7.
2012: Siok-Lay Tan; Toshiyuki Ohtsuka; Aitor González; Ryoichiro Kageyama
MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain.
Genes to cells : devoted to molecular & cellular mechanisms 2012;17(12):952-61.
2012: Siok-Lay Tan; Hiroyuki Aburatani; Asuka Kamio-Miura; Toshiyuki Matsui; Miyuki Nishi; Toshiyuki Ohtsuka; Yoichi Shinkai; Keiko Takemoto; Ryoichiro Kageyama
Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development.
Development (Cambridge, England) 2012;139(20):3806-16.
2012: Taro Ueo; Tsutomu Chiba; Itaru Imayoshi; Taeko Kobayashi; Hiroshi Nakase; Toshiyuki Ohtsuka; Hiroshi Seno; Ryoichiro Kageyama
The role of Hes genes in intestinal development, homeostasis and tumor formation.
Development (Cambridge, England) 2012;139(6):1071-82.
2011: Toshiyuki Ohtsuka; Hiromi Shimojo; Naoki Watanabe; Kohei Kometani; Mitsuhiro Matsunaga; Nagahiro Minato; Ryoichiro Kageyama
Gene expression profiling of neural stem cells and identification of regulators of neural differentiation during cortical development.
Stem cells (Dayton, Ohio) 2011;29(11):1817-28.
2011: Masayuki Sakamoto; Itaru Imayoshi; Toshiyuki Ohtsuka; Masahiro Yamaguchi; Kensaku Mori; Ryoichiro Kageyama
Continuous neurogenesis in the adult forebrain is required for innate olfactory responses.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(20):8479-84.
2011: Yoshiki Takashima; Toshiyuki Ohtsuka; Aitor González; Hitoshi Miyachi; Ryoichiro Kageyama
Intronic delay is essential for oscillatory expression in the segmentation clock.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(8):3300-5.
2011: Hiromi Shimojo; Toshiyuki Ohtsuka; Ryoichiro Kageyama
Dynamic expression of notch signaling genes in neural stem/progenitor cells.
Frontiers in neuroscience 2011;5():78.
2009: Ryoichiro Kageyama; Toshiyuki Ohtsuka; Hiromi Shimojo; Itaru Imayoshi
Dynamic regulation of Notch signaling in neural progenitor cells.
Current opinion in cell biology 2009;21(6):733-40.
2009: Itaru Imayoshi; Masayuki Sakamoto; Toshiyuki Ohtsuka; Ryoichiro Kageyama
Continuous neurogenesis in the adult brain.
Development, growth & differentiation 2009;51(3):379-86.
2008: Ryoichiro Kageyama; Toshiyuki Ohtsuka; Hiromi Shimojo; Itaru Imayoshi
Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition.
Nature neuroscience 2008;11(11):1247-51.
2008: Itaru Imayoshi; Masayuki Sakamoto; Toshiyuki Ohtsuka; Keizo Takao; Tsuyoshi Miyakawa; Masahiro Yamaguchi; Kensaku Mori; Toshio Ikeda; Shigeyoshi Itohara; Ryoichiro Kageyama
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.
Nature neuroscience 2008;11(10):1153-61.
2008: Itaru Imayoshi; Tomomi Shimogori; Toshiyuki Ohtsuka; Ryoichiro Kageyama
Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline.
Development (Cambridge, England) 2008;135(15):2531-41.
2008: Ryoichiro Kageyama; Toshiyuki Ohtsuka; Taeko Kobayashi
Roles of Hes genes in neural development.
Development, growth & differentiation 2008;50 Suppl 1():S97-103.
2008: Hiromi Shimojo; Toshiyuki Ohtsuka; Ryoichiro Kageyama
Oscillations in notch signaling regulate maintenance of neural progenitors.
Neuron 2008;58(1):52-64.
2008: Hiroshi Kokubu; Toshiyuki Ohtsuka; Ryoichiro Kageyama
Mash1 is required for neuroendocrine cell development in the glandular stomach.
Genes to cells : devoted to molecular & cellular mechanisms 2008;13(1):41-51.
2007: Shigeki Yoshiura; Toshiyuki Ohtsuka; Yoshiko Takenaka; Hiroki Nagahara; Kenichi Yoshikawa; Ryoichiro Kageyama
Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(27):11292-7.
2007: Teruyuki Muraguchi; Yujiro Takegami; Toshiyuki Ohtsuka; Shunsuke Kitajima; Ediriweera P S Chandana; Akira Omura; Takao Miki; Rei Takahashi; Naoya Matsumoto; Andreas Ludwig; Makoto Noda; Chiaki Takahashi
RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity.
Nature neuroscience 2007;10(7):838-45.
2007: Aya Kita; Itaru Imayoshi; Masato Hojo; Masashi Kitagawa; Hiroshi Kokubu; Ryosuke Ohsawa; Toshiyuki Ohtsuka; Ryoichiro Kageyama; Nobuo Hashimoto
Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development.
Molecular endocrinology (Baltimore, Md.) 2007;21(6):1458-66.
2007: Ryoichiro Kageyama; Toshiyuki Ohtsuka; Taeko Kobayashi
The Hes gene family: repressors and oscillators that orchestrate embryogenesis.
Development (Cambridge, England) 2007;134(7):1243-51.
2006: Joung Hee Baek; Jun Hatakeyama; Susumu Sakamoto; Toshiyuki Ohtsuka; Ryoichiro Kageyama
Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system.
Development (Cambridge, England) 2006;133(13):2467-76.
2006: Itaru Imayoshi; Toshiyuki Ohtsuka; Daniel Metzger; Pierre Chambon; Ryoichiro Kageyama
Temporal regulation of Cre recombinase activity in neural stem cells.
Genesis (New York, N.Y. : 2000) 2006;44(5):233-8.
2006: Yoshito Masamizu; Toshiyuki Ohtsuka; Yoshiki Takashima; Hiroki Nagahara; Yoshiko Takenaka; Kenichi Yoshikawa; Hitoshi Okamura; Ryoichiro Kageyama
Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1313-8.
2006: Toshiyuki Ohtsuka; Itaru Imayoshi; Hiromi Shimojo; Eiichiro Nishi; Ryoichiro Kageyama; Susan K McConnell
Visualization of embryonic neural stem cells using Hes promoters in transgenic mice.
Molecular and cellular neurosciences 2006;31(1):109-22.
2005: Ryosuke Ohsawa; Toshiyuki Ohtsuka; Ryoichiro Kageyama
Mash1 and Math3 are required for development of branchiomotor neurons and maintenance of neural progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(25):5857-65.
2005: Ryoichiro Kageyama; Toshiyuki Ohtsuka; Jun Hatakeyama; Ryosuke Ohsawa
Roles of bHLH genes in neural stem cell differentiation.
Experimental cell research 2005;306(2):343-8.
2003: Masami Sakamoto; Hiromi Hirata; Toshiyuki Ohtsuka; Yasumasa Bessho; Ryoichiro Kageyama
The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain.
The Journal of biological chemistry 2003;278(45):44808-15.
2002: Hiromi Hirata; Shigeki Yoshiura; Toshiyuki Ohtsuka; Yasumasa Bessho; Takahiro Harada; Kenichi Yoshikawa; Ryoichiro Kageyama
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop.
Science (New York, N.Y.) 2002;298(5594):840-3.
2001: Toshiyuki Ohtsuka; M Sakamoto; François Guillemot; Ryoichiro Kageyama
Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain.
The Journal of biological chemistry 2001;276(32):30467-74.
2000: Hiromi Hirata; Toshiyuki Ohtsuka; Yasumasa Bessho; Ryoichiro Kageyama
Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons.
The Journal of biological chemistry 2000;275(25):19083-9.
2000: Masato Hojo; Toshiyuki Ohtsuka; Nobuo Hashimoto; Gérard Gradwohl; François Guillemot; Ryoichiro Kageyama
Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina.
Development (Cambridge, England) 2000;127(12):2515-22.
2000: Ryoichiro Kageyama; Toshiyuki Ohtsuka
[Notch pathway in neural development].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(3 Suppl):221-6.
1999: Ryoichiro Kageyama; Toshiyuki Ohtsuka
The Notch-Hes pathway in mammalian neural development.
Cell research 1999;9(3):179-88.
1999: Toshiyuki Ohtsuka; M Ishibashi; Gérard Gradwohl; Shigetada Nakanishi; François Guillemot; Ryoichiro Kageyama
Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.
The EMBO journal 1999;18(8):2196-207.
1998: Toshiyuki Ohtsuka; M Asahi; N Matsuura; Haruhiko Kikuchi; Masato Hojo; Ryoichiro Kageyama; H Ohkubo; M Hoshimaru
Regulated expression of neurogenic basic helix-loop-helix transcription factors during differentiation of the immortalized neuronal progenitor cell line HC2S2 into neurons.
Cell and tissue research 1998;293(1):23-9.
1997: M Asahi; M Hoshimaru; Y Uemura; T Tokime; M Kojima; Toshiyuki Ohtsuka; N Matsuura; Takashi Aoki; KI Shibahara; Haruhiko Kikuchi
Expression of interleukin-1 beta converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(1):11-8.
1996: M Kojima; M Hoshimaru; T Aoki; J B Takahashi; Toshiyuki Ohtsuka; M Asahi; N Matsuura; H Kikuchi
Expression of heat shock proteins in the developing rat retina.
Neuroscience letters 1996;205(3):215-7.