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Iwao Ojima

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Kaloko Joseph J; Teng Yu-Han Gary; Ojima Iwao
One-step formation of fused tetracyclic skeletons from cyclohexene-diynes and carbon monoxide through Rh(I)-catalyzed [2 + 2 + 2 + 1] cycloaddition reaction.
Pepe Antonella; Sun Liang; Zanardi Ilaria; Wu Xinyuan; Ferlini Cristiano; Fontana Gabriele; Bombardelli Ezio; Ojima Iwao
Novel C-seco-taxoids possessing high potency against paclitaxel-resistant cancer cell lines overexpressing class III beta-tubulin.
Sun Liang; Simmerling Carlos; Ojima Iwao
Recent advances in the study of the bioactive conformation of taxol.

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All Publications

2009: Kaloko Joseph J; Teng Yu-Han Gary; Ojima Iwao
One-step formation of fused tetracyclic skeletons from cyclohexene-diynes and carbon monoxide through Rh(I)-catalyzed [2 + 2 + 2 + 1] cycloaddition reaction.
Chemical communications (Cambridge, England) 2009;(30):4569-71.
2009: Pepe Antonella; Sun Liang; Zanardi Ilaria; Wu Xinyuan; Ferlini Cristiano; Fontana Gabriele; Bombardelli Ezio; Ojima Iwao
Novel C-seco-taxoids possessing high potency against paclitaxel-resistant cancer cell lines overexpressing class III beta-tubulin.
Bioorganic & medicinal chemistry letters 2009;19(12):3300-4.
2009: Sun Liang; Simmerling Carlos; Ojima Iwao
Recent advances in the study of the bioactive conformation of taxol.
ChemMedChem 2009;4(5):719-31.
2009: Ojima Iwao; Das Manisha
Recent Advances in the Chemistry and Biology of New Generation Taxoids (double dagger).
Journal of natural products 2009;72(3):554-65.
2008: Sun Liang; Geng Xudong; Geney Raphaël; Li Yuan; Simmerling Carlos; Li Zhong; Lauher Joseph W; Xia Shujun; Horwitz Susan B; Veith Jean M; Pera Paula; Bernacki Ralph J; Ojima Iwao
Design, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids.
The Journal of organic chemistry 2008;73(24):9584-93.
2008: Respicio Laurel; Nair Pravin A; Huang Qing; Anil Burcu; Tracz Sylvia; Truglio James J; Kisker Caroline; Raleigh Daniel P; Ojima Iwao; Knudson Dennis L; Tonge Peter J; Slayden Richard A
Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery.
Tuberculosis (Edinburgh, Scotland) 2008;88(5):420-9.
2007: Chiou Wen-Hua; Schoenfelder Angèle; Sun Liang; Mann André; Ojima Iwao
Rhodium-catalyzed cyclohydrocarbonylation approach to the syntheses of enantiopure homokainoids.
The Journal of organic chemistry 2007;72(25):9418-25.
2007: Chiou Wen-Hua; Mizutani Nobihiro; Ojima Iwao
Highly efficient synthesis of azabicyclo[x.y.0]alkane amino acids and congeners by means of Rh-catalyzed cyclohydrocarbonylation.
The Journal of organic chemistry 2007;72(6):1871-82.
2007: Huang Qing; Tonge Peter J; Slayden Richard A; Kirikae Teruo; Ojima Iwao
FtsZ: a novel target for tuberculosis drug discovery.
Current topics in medicinal chemistry 2007;7(5):527-43.
2006: Chapsal Bruno D; Ojima Iwao
Total synthesis of enantiopure (+)-gamma-lycorane using highly efficient Pd-catalyzed asymmetric allylic alkylation.
Organic letters 2006;8(7):1395-8.
2006: Kuznetsova Larissa; Chen Jin; Sun Liang; Wu Xinyuan; Pepe Antonella; Veith Jean M; Pera Paula; Bernacki Ralph J; Ojima Iwao
Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents.
Bioorganic & medicinal chemistry letters 2006;16(4):974-7.
2006: Huang Qing; Kirikae Fumiko; Kirikae Teruo; Pepe Antonella; Amin Amol; Respicio Laurel; Slayden Richard A; Tonge Peter J; Ojima Iwao
Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents.
Journal of medicinal chemistry 2006;49(2):463-6.
2005: Bennacer Bibia; Fujiwara Masaki; Lee Seung-Yub; Ojima Iwao
Silicon-initiated carbonylative carbotricyclization and [2+2+2+1] cycloaddition of enediynes catalyzed by rhodium complexes.
Journal of the American Chemical Society 2005;127(50):17756-67.
2005: Chen Jin; Jaracz Stanislav; Zhao Xianrui; Chen Shuyi; Ojima Iwao
Antibody-cytotoxic agent conjugates for cancer therapy.
Expert opinion on drug delivery 2005;2(5):873-90.
2005: Jaracz Stanislav; Chen Jin; Kuznetsova Larisa V; Ojima Iwao
Recent advances in tumor-targeting anticancer drug conjugates.
Bioorganic & medicinal chemistry 2005;13(17):5043-54.
2005: Ehrlichova Marie; Vaclavikova Radka; Ojima Iwao; Pepe Antonella; Kuznetsova Larisa V; Chen Jin; Truksa Jaroslav; Kovar Jan; Gut Ivan
Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells.
Naunyn-Schmiedeberg's archives of pharmacology 2005;372(1):95-105.
2005: Yang Chia-Ping Huang; Verdier-Pinard Pascal; Wang Fang; Lippaine-Horvath Eva; He Lifeng; Li Dansu; Höfle Gerhard; Ojima Iwao; Orr George A; Horwitz Susan Band
A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence.
Molecular cancer therapeutics 2005;4(6):987-95.
2005: Geney R; Chen J; Ojima I
Recent advances in the new generation taxane anticancer agents.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2005;1(2):125-39.
2005: Geney Raphaël; Sun Liang; Pera Paula; Bernacki Ralph J; Xia Shujun; Horwitz Susan B; Simmerling Carlos L; Ojima Iwao
Use of the tubulin bound paclitaxel conformation for structure-based rational drug design.
Chemistry & biology 2005;12(3):339-48.
2005: Ojima Iwao; Borella Christopher P; Wu Xinyuan; Bounaud Pierre-Yves; Oderda Cecilia Fumero; Sturm Matthew; Miller Michael L; Chakravarty Subrata; Chen Jin; Huang Qing; Pera Paula; Brooks Tracy A; Baer Maria R; Bernacki Ralph J
Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents.
Journal of medicinal chemistry 2005;48(6):2218-28.
2004: Bennacer Bibia; Fujiwara Masaki; Ojima Iwao
Novel [2 + 2 + 2 + 1] cycloaddition of enediynes catalyzed by rhodium complexes.
Organic letters 2004;6(20):3589-91.
2004: Choi Hojae; Hua Zihao; Ojima Iwao
Highly enantioselective copper-catalyzed conjugate addition of diethylzinc to nitroalkenes.
Organic letters 2004;6(16):2689-91.
2004: Miller Michael L; Roller Elizabeth E; Wu Xinyaun; Leece Barbara A; Goldmacher Victor S; Chari Ravi V J; Ojima Iwao
Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies.
Bioorganic & medicinal chemistry letters 2004;14(15):4079-82.
2004: Geng Xudong; Geney Raphaël; Pera Paula; Bernacki Ralph J; Ojima Iwao
Design and synthesis of de novo cytotoxic alkaloids through mimicking taxoid skeleton.
Bioorganic & medicinal chemistry letters 2004;14(13):3491-4.
2004: Minderman Hans; Brooks Tracy A; O'Loughlin Kieran L; Ojima Iwao; Bernacki Ralph J; Baer Maria R
Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023.
Cancer chemotherapy and pharmacology 2004;53(5):363-9.
2004: Hua Zihao; Vassar Victor C; Choi Hojae; Ojima Iwao
New biphenol-based, fine-tunable monodentate phosphoramidite ligands for catalytic asymmetric transformations.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5411-6.
2004: Brooks Tracy A; Kennedy Daniel R; Gruol Donald J; Ojima Iwao; Baer Maria R; Bernacki Ralph J
Structure-activity analysis of taxane-based broad-spectrum multidrug resistance modulators.
Anticancer research 2004;24(2A):409-15.
2004: Wu X; Ojima I
Tumor specific novel taxoid-monoclonal antibody conjugates.
Current medicinal chemistry 2004;11(4):429-38.
2003: Brooks Tracy A; Minderman Hans; O'Loughlin Kieran L; Pera Paula; Ojima Iwao; Baer Maria R; Bernacki Ralph J;
Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.
Molecular cancer therapeutics 2003;2(11):1195-205.
2003: Hua Zihao; Vassar Victor C; Ojima Iwao
Synthesis of new chiral monodentate phosphite ligands and their use in catalytic asymmetric hydrogenation.
Organic letters 2003;5(21):3831-4.
2003: Geng Xudong; Miller Michael L; Lin Songnian; Ojima Iwao
Synthesis of novel C2-C3'N-linked macrocyclic taxoids by means of highly regioselective Heck macrocyclization.
Organic letters 2003;5(20):3733-6.
2003: Ojima Iwao; Ferlini Cristiano
New insights into drug resistance in cancer.
Chemistry & biology 2003;10(7):583-4.
2003: Ojima Iwao; Fumero-Oderda Cecilia L; Kuduk Scott D; Ma Zhuping; Kirikae Fumiko; Kirikae Teruo
Structure-activity relationship study of taxoids for their ability to activate murine macrophages as well as inhibit the growth of macrophage-like cells.
Bioorganic & medicinal chemistry 2003;11(13):2867-88.
2003: Ojima Iwao; Geney Raphaël
109881 Aventis.
Current opinion in investigational drugs (London, England : 2000) 2003;4(6):737-40.
2003: Ojima Iwao; Geney Raphaël
BMS-184476 Bristol-Myers Squibb.
Current opinion in investigational drugs (London, England : 2000) 2003;4(6):732-6.
2002: Mizutani Nobuhiro; Chiou Wen-Hua; Ojima Iwao
New and efficient synthesis of azabicyclo[4.4.0]alkane amino acids by Rh-catalyzed cyclohydrocarbonylation.
Organic letters 2002;4(26):4575-8.
2002: Ojima Iwao; Geng Xudong; Wu Xinyuan; Qu Chuanxing; Borella Christopher P; Xie Hongsheng; Wilhelm Sharon D; Leece Barbara A; Bartle Laura M; Goldmacher Victor S; Chari Ravi V J
Tumor-specific novel taxoid-monoclonal antibody conjugates.
Journal of medicinal chemistry 2002;45(26):5620-3.
2002: Geney Raphaël; Ungureanu loana Maria; Li Dansu; Ojima Iwao
Overcoming multidrug resistance in taxane chemotherapy.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2002;40(9):918-25.
2002: Ojima Iwao; Vu An T; Lee Seung-Yub; McCullagh James V; Moralee Andrew C; Fujiwara Masaki; Hoang Tram H
Rhodium-catalyzed silylcarbocyclization (SiCaC) and carbonylative silylcarbocyclization (CO-SiCaC) reactions of enynes.
Journal of the American Chemical Society 2002;124(31):9164-74.
2002: Ojima Iwao; Geney Raphael; Ungureanu Ioana Maria; Li Dansu
Medicinal chemistry and chemical biology of new generation taxane antitumor agents.
IUBMB life 2002;53(4-5):269-74.
2002: Chuang Chih-Yuan; Vassar Victor C; Ma Zuping; Geney Raphaël; Ojima Iwao
Electronic effects on the regio- and enantioselectivity of the asymmetric aminohydroxylation of O-substituted 4-hydroxy-2-butenoates.
Chirality 2002;14(2-3):151-62.
2002: Ojima Iwao; Geng Xudong; Lin Songnian; Pera Paula; Bernacki Ralph J
Design, synthesis and biological activity of novel C2-C3' N-Linked macrocyclic taxoids.
Bioorganic & medicinal chemistry letters 2002;12(3):349-52.
2001: Chibale K; Ojima I; Haupt H; Geng X; Pera P; Bernacki R J
Modulation of human mammary cell sensitivity to paclitaxel by new quinoline sulfonamides.
Bioorganic & medicinal chemistry letters 2001;11(18):2457-60.
2001: Vredenburg M R; Ojima I; Veith J; Pera P; Kee K; Cabral F; Sharma A; Kanter P; Greco W R; Bernacki R J
Effects of orally active taxanes on P-glycoprotein modulation and colon and breast carcinoma drug resistance.
Journal of the National Cancer Institute 2001;93(16):1234-45.
2001: Bonafoux D; Ojima I
Novel DMAP-catalyzed skeletal rearrangement of 5-exo-(2-hydroxy-ethylene)oxasilacyclopentanes.
Organic letters 2001;3(15):2333-5.
2001: Bonafoux D; Ojima I
Desymmetrization of 4-dimethylsiloxy-1,6-heptadiynes through sequential double silylformylation.
Organic letters 2001;3(9):1303-5.
2000: Kirikae T; Ojima I; Fuero-Oderda C; Lin S; Kirikae F; Hashimoto M; Nakanoc M
Structural significance of the acyl group at the C-10 position and the A ring of the taxane core of paclitaxel for inducing nitric oxide and tumor necrosis factor production by murine macrophages.
FEBS letters 2000;478(3):221-6.
2000: Ojima I; Lin S; Slater J C; Wang T; Pera P; Bernacki R J; Ferlini C; Scambia G
Syntheses and biological activity of C-3'-difluoromethyl-taxoids.
Bioorganic & medicinal chemistry 2000;8(7):1619-28.
2000: Lin S; Geng X; Qu C; Tynebor R; Gallagher D J; Pollina E; Rutter J; Ojima I
Synthesis of highly potent second-generation taxoids through effective kinetic resolution coupling of racemic beta-lactams with baccatins.
Chirality 2000;12(5-6):431-41.
1999: Ojima I; Wang T; Miller M L; Lin S; Borella C P; Geng X; Pera P; Bernacki R J
Synthesis and structure-activity relationships of new second-generation taxoids.
Bioorganic & medicinal chemistry letters 1999;9(24):3423-8.
1999: Rao S; He L; Chakravarty S; Ojima I; Orr G A; Horwitz S B
Characterization of the Taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol.
The Journal of biological chemistry 1999;274(53):37990-4.
1999: Ojima I; Lin S; Wang T
Recent advances in the medicinal chemistry of taxoids with novel beta-amino acid side chains.
Current medicinal chemistry 1999;6(10):927-54.
1999: Ojima I; Bounaud P Y; Ahern D G
New photoaffinity analogs of paclitaxel.
Bioorganic & medicinal chemistry letters 1999;9(8):1189-94.
1999: Ojima I; Chakravarty S; Inoue T; Lin S; He L; Horwitz S B; Kuduk S D; Danishefsky S J
A common pharmacophore for cytotoxic natural products that stabilize microtubules.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4256-61.
1998: Wu Q; Bounaud P Y; Kuduk S D; Yang C P; Ojima I; Horwitz S B; Orr G A
Identification of the domains of photoincorporation of the 3'- and 7-benzophenone analogues of taxol in the carboxyl-terminal half of murine mdr1b P-glycoprotein.
Biochemistry 1998;37(32):11272-9.
1998: Ojima I; Bounaud P Y; Takeuchi C; Pera P; Bernacki R J
New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells.
Bioorganic & medicinal chemistry letters 1998;8(2):189-94.
1997: Ojima I; Kuduk S D; Pera P; Veith J M; Bernacki R J
Synthesis and structure-activity relationships of nonaromatic taxoids: effects of alkyl and alkenyl ester groups on cytotoxicity.
Journal of medicinal chemistry 1997;40(3):279-85.
1997: Ojima I; Slater J C; Kuduk S D; Takeuchi C S; Gimi R H; Sun C M; Park Y H; Pera P; Veith J M; Bernacki R J
Syntheses and structure-activity relationships of taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.
Journal of medicinal chemistry 1997;40(3):267-78.
1997: Ojima I; Slater J C
Synthesis of novel 3'-trifluoromethyl taxoids through effective kinetic resolution of racemic 4-CF3-beta-lactams with baccatins.
Chirality 1997;9(5-6):487-94.
1996: Kirikae T; Ojima I; Kirikae F; Ma Z; Kuduk S D; Slater J C; Takeuchi C S; Bounaud P Y; Nakano M
Structural requirements of taxoids for nitric oxide and tumor necrosis factor production by murine macrophages.
Biochemical and biophysical research communications 1996;227(1):227-35.
1996: Ojima I; Slater J C; Michaud E; Kuduk S D; Bounaud P Y; Vrignaud P; Bissery M C; Veith J M; Pera P; Bernacki R J
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells.
Journal of medicinal chemistry 1996;39(20):3889-96.
1995: Sharma A; Straubinger R M; Ojima I; Bernacki R J
Antitumor efficacy of taxane liposomes on a human ovarian tumor xenograft in nude athymic mice.
Journal of pharmaceutical sciences 1995;84(12):1400-4.
1995: Ojima I; Duclos O; Dormán G; Simonot B; Prestwich G D; Rao S; Lerro K A; Horwitz S B
A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and P-glycoprotein.
Journal of medicinal chemistry 1995;38(20):3891-4.
1995: Ojima I; Chakravarty S; Dong Q
Antithrombotic agents: from RGD to peptide mimetics.
Bioorganic & medicinal chemistry 1995;3(4):337-60.
1994: Ojima I; Duclos O; Zucco M; Bissery M C; Combeau C; Vrignaud P; Riou J F; Lavelle F
Synthesis and structure-activity relationships of new antitumor taxoids. Effects of cyclohexyl substitution at the C-3' and/or C-2 of taxotere (docetaxel).
Journal of medicinal chemistry 1994;37(16):2602-8.
1994: Ojima I; Park Y H; Sun C M; Fenoglio I; Appendino G; Pera P; Bernacki R J
Structure-activity relationships of new taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.
Journal of medicinal chemistry 1994;37(10):1408-10.
1994: Ojima I; Jameison F A; Pete B; Radunz H; Schittenhelm C; Lindner H J; Emith A E
Design, synthesis and enzyme inhibitory activities of new trifluoromethyl-containing inhibitors for angiotensin converting enzyme.
Drug design and discovery 1994;11(2):91-113.

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Iwao Ojima

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