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Susumu Okabe
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81
Takeuchi, Koji
26
Takahashi, S
11
Amagase, Kikuko
11
Furukawa, O
6
Keto, Yoshihiro
6
Tsukimi, Y
5
Tomita, Kazuyoshi
5
Furutani, Kazuharu
5
Aihara, Takeshi
4
Ebata, Misako
4
Fujishita, Teruaki
4
Fujita, H
4
Nakamura, Eiji
3
Matsui, H
3
Matsuno, K
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All Publications
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2006: Takada-Takatori Yuki; Kume Toshiaki; Sugimoto Mitsuhiro; Katsuki Hiroshi; Niidome Tetsuhiro; Sugimoto Hachiro; Fujii Takeshi; Okabe Susumu; Akaike Akinori
Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity.
European journal of pharmacology 2006;549(1-3):19-26.
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2005: Okabe Susumu; Amagase Kikuko
An overview of acetic acid ulcer models--the history and state of the art of peptic ulcer research.
Biological & pharmaceutical bulletin 2005;28(8):1321-41.
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2005: Tomita Kazuyoshi; Okabe Susumu
Exogenous histamine stimulates colorectal cancer implant growth via immunosuppression in mice.
Journal of pharmacological sciences 2005;97(1):116-23.
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2005: Okabe Susumu
[Acetic acid-induced gastro-duodenal ulcers in experimental animals--examples of serendipity and pseudoserendipity]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2005;125(1):17-29.
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2004: Nakamura Eiji; Kataoka Takashi; Furutani Kazuharu; Jimbo Keisuke; Aihara Takeshi; Tanaka Satoshi; Ichikawa Atsushi; Ohtsu Hiroshi; Okabe Susumu
Lack of histamine alters gastric mucosal morphology: comparison of histidine decarboxylase-deficient and mast cell-deficient mice.
American journal of physiology. Gastrointestinal and liver physiology 2004;287(5):G1053-61.
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2004: Hata Y; Murakami M; Okabe S
Glycoconjugates with NeuAc-NeuAc-Gal-Glc are more effective at preventing adhesion of Helicobacter pylori to gastric epithelial cells than glycoconjugates with NeuAc-Gal-Glc.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2004;55(3):607-25.
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2004: Kanatani K; Ebata M; Murakami M; Okabe S
Effects of indomethacin and rofecoxib on gastric mucosal damage in normal and Helicobacter pylori-infected mongolian gerbils.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2004;55(1 Pt 2):207-22.
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2003: Aihara Takeshi; Fujishita Teruaki; Kanatani Keiko; Furutani Kazuharu; Nakamura Eiji; Taketo Makoto M; Matsui Minoru; Chen Duan; Okabe Susumu
Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice.
Gastroenterology 2003;125(6):1774-84.
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2003: Okabe Susumu; Fujishita Teruaki; Jinbo Keisuke
[New target for the inhibitors of gastric acid secretion. Inhibition of myosin and actin activities via the apical membrane of parietal cells in dogs]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122 Suppl():74P-77P.
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2003: Tomita Kazuyoshi; Izumi Kazuki; Okabe Susumu
Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice.
Journal of pharmacological sciences 2003;93(3):321-30.
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2003: Furutani Kazuharu; Aihara Takeshi; Nakamura Eiji; Tanaka Satoshi; Ichikawa Atsushi; Ohtsu Hiroshi; Okabe Susumu
Crucial role of histamine for regulation of gastric acid secretion ascertained by histidine decarboxylase-knockout mice.
The Journal of pharmacology and experimental therapeutics 2003;307(1):331-8.
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2003: Amagase K; Yokota M; Tsukimi Y; Okabe S
Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2003;54(3):349-60.
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2003: Okabe Susumu; Amagase Kikuko
[An overview of acetic acid ulcer models and their utility for drug screening]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(1):73-92.
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2003: Amagase Kikuko; Okabe Susumu
On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion.
Journal of pharmacological sciences 2003;92(2):124-36.
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2003: Aihara Takeshi; Nakamura Eiji; Amagase Kikuko; Tomita Kazuyoshi; Fujishita Teruaki; Furutani Kazuharu; Okabe Susumu
Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future.
Pharmacology & therapeutics 2003;98(1):109-27.
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2003: Ogawa Toshiki; Maeda Kazuhiko; Tonai Shunsuke; Kobayashi Takashi; Watanabe Takeshi; Okabe Susumu
Utilization of knockout mice to examine the potential role of gastric histamine H2-receptors in Menetrier's disease.
Journal of pharmacological sciences 2003;91(1):61-70.
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2002: Okabe Susumu; Furutani Kazuharu; Maeda Kazuhiko; Aihara Takeshi; Fujishita Teruaki; Tonai Shunsuke
[Regulatory mechanism of gastric acid secretion and mucosal integrity--an analysis with various gene deficient mice]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(3):159-71.
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2002: Keto Yoshihiro; Ebata Misako; Tomita Kazuyoshi; Okabe Susumu
Influence of Helicobacter pylori infection on healing and relapse of acetic acid ulcers in Mongolian gerbils.
Digestive diseases and sciences 2002;47(4):837-49.
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2002: Matsuno K; Tomita K; Okabe S
Wine stimulates gastric acid secretion in isolated rabbit gastric glands via two different pathways.
Alimentary pharmacology & therapeutics 2002;16 Suppl 2():107-14.
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2002: Tanaka Satoshi; Hamada Kiyoma; Yamada Noboru; Sugita Yuko; Tonai Shunsuke; Hunyady Bèla; Palkovits Miklòs; Falus Andras; Watanabe Takehiko; Okabe Susumu; Ohtsu Hiroshi; Ichikawa Atsushi; Nagy Andras
Gastric acid secretion in L-histidine decarboxylase-deficient mice.
Gastroenterology 2002;122(1):145-55.
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2001: Okabe S; Shimosako K; Amagase K
Pharmacological regulation of gastric acid secretion in the apical membrane of parietal cells; a new target for antisecretory drugs.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2001;52(4 Pt 1):639-56.
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2001: Keto Y; Ebata M; Okabe S
[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2001;118(4):259-68.
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2001: Tsukimi Y; Nakai H; Itoh S; Amagase K; Okabe S
Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2001;52(3):391-406.
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2001: Kobayashi N; Kataoka T; Ono A; Tsukimi Y; Okabe S
Role of p38 mitogen-activated protein kinase in the healing of gastric ulcers in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2001;52(2):195-210.
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2001: Yamada H; Aihara T; Okabe S
Mechanism for Helicobacter pylori stimulation of interleukin-8 production in a gastric epithelial cell line (MKN 28): roles of mitogen-activated protein kinase and interleukin-1beta.
Biochemical pharmacology 2001;61(12):1595-604.
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2001: Naka Y; Aihara T; Keto Y; Okabe S
Effects of dexamethasone and FK506 on Helicobacter pylori-induced gastritis and bacterial viability in Mongolian gerbils.
Journal of physiology, Paris 2001;95(1-6):443-51.
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2001: Keto Y; Ebata M; Okabe S
Gastric mucosal changes induced by long term infection with Helicobacter pylori in Mongolian gerbils: effects of bacteria eradication.
Journal of physiology, Paris 2001;95(1-6):429-36.
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2001: Tsukimi Y; Ogawa T; Okabe S
Pharmacological analysis of wine-stimulated gastric acid secretion in dogs.
Journal of physiology, Paris 2001;95(1-6):221-8.
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2001: Tsukimi Y; Okabe S
Recent advances in gastrointestinal pathophysiology: role of heat shock proteins in mucosal defense and ulcer healing.
Biological & pharmaceutical bulletin 2001;24(1):1-9.
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2000: Ishikawa M; Tsukimi Y; Ogawa T; Okabe S
Endogenous nitric oxide proves not to be involved in the inhibition by IL-1beta of TGF-alpha-stimulated proliferation of RGM1 cells.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2000;51(3):411-9.
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2000: Matsuno K; Sasaki N; Okabe S
Gastric acid secretion in dogs in response to combinations of beer, ethanol and peptone meal--the role of endogenous gastrin.
Alimentary pharmacology & therapeutics 2000;14 Suppl 1():109-15.
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2000: Sasaki N; Matsuno K; Okabe S
Selective action of a CCK-B/gastrin receptor antagonist, S-0509, on pentagastrin-, peptone meal- and beer-stimulated gastric acid secretion in dogs.
Alimentary pharmacology & therapeutics 2000;14(4):479-88.
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1999: Takahashi S; Takeuchi K; Okabe S
EP4 receptor mediation of prostaglandin E2-stimulated mucus secretion by rabbit gastric epithelial cells.
Biochemical pharmacology 1999;58(12):1997-2002.
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1999: Takahashi S; Kobayashi N; Okabe S
Regulation by endogenous interleukin-1 of mRNA expression of healing-related factors in gastric ulcers in rats.
The Journal of pharmacology and experimental therapeutics 1999;291(2):634-41.
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1999: Nakamura E; Takahashi S; Ishikawa M; Okabe S
Inhibitory effect of macrophage-derived factors on the recovery of wounds induced in rat gastric epithelial monolayers.
Biochemical pharmacology 1999;58(7):1221-7.
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1999: Okabe S
Hypothesis--origin of parietal cells: transfer of the H+K+-ATPase gene from parasitic microorganisms to Cnidaria?
The Chinese journal of physiology 1999;42(3):121-8.
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1999: Amagase K; Okabe S
A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1999;50(2):169-81.
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1999: Yamada H; Takahashi S; Fujita H; Kobayashi N; Okabe S
Cytokine-induced neutrophil chemoattractants in healing of gastric ulcers in rats: expression of >40-kDa chemoattractant in delayed ulcer healing by indomethacin.
Digestive diseases and sciences 1999;44(5):889-95.
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1999: Amagase K; Ikeda K; Okabe S
Antisecretory and ulcer healing effects of S-0509, a novel CCK-B/gastrin receptor antagonist, in rats.
Digestive diseases and sciences 1999;44(5):879-88.
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1999: Keto Y; Takahashi S; Okabe S
Healing of Helicobacter pylori-induced gastric ulcers in Mongolian gerbils: combined treatment with omeprazole and clarithromycin.
Digestive diseases and sciences 1999;44(2):257-65.
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1999: Furukawa O; Matsui H; Suzuki N; Okabe S
Epidermal growth factor protects rat epithelial cells against acid-induced damage through the activation of Na+/H+ exchangers.
The Journal of pharmacology and experimental therapeutics 1999;288(2):620-6.
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1999: Takahashi S; Shigeta J; Ishikawa M; Kobayashi N; Okabe S
Role of thromboxane A2 in healing of gastric ulcers in rats.
Japanese journal of pharmacology 1999;79(1):101-7.
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1998: Suzuki N; Takahashi S; Okabe S
Relationship between vascular endothelial growth factor and angiogenesis in spontaneous and indomethacin-delayed healing of acetic acid-induced gastric ulcers in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1998;49(4):515-27.
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1998: Takahashi S; Shigeta J; Inoue H; Tanabe T; Okabe S
Localization of cyclooxygenase-2 and regulation of its mRNA expression in gastric ulcers in rats.
The American journal of physiology 1998;275(5 Pt 1):G1137-45.
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1998: Takahashi S; Nakamura E; Okabe S
Effects of cytokines, without and with Helicobacter pylori components, on mucus secretion by cultured gastric epithelial cells.
Digestive diseases and sciences 1998;43(10):2301-8.
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1998: Shigeta J; Takahashi S; Okabe S
Role of cyclooxygenase-2 in the healing of gastric ulcers in rats.
The Journal of pharmacology and experimental therapeutics 1998;286(3):1383-90.
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1998: Takahashi S; Okabe S
Mechanism by which orally administered leminoprazole stimulates mucus synthesis in rats.
Pharmacology 1998;57(1):47-56.
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1998: Furukawa O; Matsui H; Suzuki N; Okabe S
Effects of transforming growth factor alpha and hepatocyte growth factor on acid-induced damage in rat gastric epithelial cells.
Japanese journal of pharmacology 1998;77(2):173-6.
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1998: Takahashi S; Okabe S
[Rodent models of Helicobacter pylori infection and their utility]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1998;111(5):289-96.
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1998: Takahashi S; Keto Y; Fujita H; Muramatsu H; Nishino T; Okabe S
Pathological changes in the formation of Helicobacter pylori-induced gastric lesions in Mongolian gerbils.
Digestive diseases and sciences 1998;43(4):754-65.
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1998: Takahashi S; Tsukahara T; Okabe S
Effects of acid-degraded products of leminoprazole on acid secretion, mucus secretion and synthesis, and indomethacin-induced damage in cell culture.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1998;49(1):99-110.
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1998: Fujita H; Takahashi S; Okabe S
Mechanism by which indomethacin delays the healing of acetic acid-induced ulcers in rats. Role of neutrophil antichemotactic and chemotactic activities.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1998;49(1):71-82.
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1998: Nakamura E; Takahashi S; Matsui H; Okabe S
Interleukin-1beta inhibits growth factor-stimulated restoration of wounded rat gastric epithelial cell monolayers.
Digestive diseases and sciences 1998;43(3):476-84.
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1998: Takahashi S; Okabe S
Roles of extracellular Ca++ and calmodulin in roxatidine-stimulated secretion and synthesis of mucus by cultured rabbit gastric mucosal cells.
The Journal of pharmacology and experimental therapeutics 1998;284(1):37-42.
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1997: Fujita H; Takahashi S; Okabe S
Characterization of antichemotactic factor extracted from the gastric mucosa of rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1997;48(4):761-74.
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1997: Furukawa O; Okabe S
Cytoprotective effect of epidermal growth factor on acid- and pepsin-induced damage to rat gastric epithelial cells: roles of Na+/H+ exchangers.
Journal of gastroenterology and hepatology 1997;12(5):353-9.
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1997: Takahashi S; Yamazaki T; Okabe S
Leminoprazole protects cultured gastric mucosal cells against damage caused by ethanol, indometacin and taurocholate.
Pharmacology 1997;54(3):118-26.
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1997: Furukawa O; Nakamura E; Okabe S
Characterization of a novel cell damage model induced by acid and pepsin using rat gastric epithelial cells: protective effect of sucralfate.
Journal of gastroenterology and hepatology 1997;12(2):115-21.
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1997: Okabe S
Hypothesis--origin of the parietal cell: microorganism?
Journal of clinical gastroenterology 1997;25 Suppl 1():S141-8.
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1997: Furukawa O; Okabe S
Effects of growth factors on acid-induced damage to rat gastric epithelial cells.
Journal of clinical gastroenterology 1997;25 Suppl 1():S79-83.
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1996: Takahashi S; Okabe S
Effects of sucralfate and its components on indomethacin-induced damage to cultured rabbit gastric mucosal cells.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1996;47(4):611-9.
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1996: Takahashi S; Okabe S
The cytoprotective effect of leminoprazole on indomethacin-induced damage to rabbit gastric mucosal cells.
The Journal of pharmacology and experimental therapeutics 1996;279(2):975-82.
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1996: Takahashi S; Yamazaki T; Okabe S
Effects of heat shock and teprenone on ethanol-induced damage to cultured rabbit gastric mucosal cells.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1996;47(3):433-41.
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1996: Tsukimi Y; Nozue C; Okabe S
Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats.
Journal of gastroenterology and hepatology 1996;11(4):335-40.
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1996: Takahashi S; Okabe S
Stimulatory effects of sucralfate on secretion and synthesis of mucus by rabbit gastric mucosal cells. Involvement of phospholipase C.
Digestive diseases and sciences 1996;41(3):498-504.
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1996: Amagase K; Kato S; Yamamoto H; Okabe S
Effects of the novel histamine H2-receptor antagonist (+/-)-(E)-1-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-3-[2-[[[5- (methylamino)methyl-2-furyl]methyl]thio]ethyl]-2-(methylsulfonyl) guanidine on gastric secretion and gastroduodenal ulcers in rats.
Arzneimittel-Forschung 1996;46(2):177-84.
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1996: Okabe S; Amagase K; Fujita H; Iwata K; Satake N; Shibata S
Vasoinhibitory effect of leminoprazole, a H+,K(+)-ATPase inhibitor, on rat aortic rings.
General pharmacology 1996;27(1):117-21.
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1995: Okabe S; Takinami Y; Iwata K; Yanagawa T
Mucosal protective effect of leminoprazole on reflux esophagitis induced in rats.
Japanese journal of pharmacology 1995;69(4):317-23.
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1995: Takahashi S; Okabe S
A histamine H2 receptor antagonist, roxatidine, stimulates mucus secretion and synthesis by cultured rabbit gastric mucosal cells.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1995;46(4):503-11.
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1995: Takahashi S; Nakamura E; Okabe S
Stimulatory effect of leminoprazole on secretion and synthesis of mucus by rabbit gastric mucosal cells.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1396-401.
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1995: Okabe S; Shimosako K; Harada H
Antisecretory effect of leminoprazole on histamine-stimulated gastric acid secretion in dogs: potent local effect.
Japanese journal of pharmacology 1995;69(2):91-100.
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1995: Tsukimi Y; Okabe S
Changes in gastric function and healing of chronic gastric ulcers in aged rats.
Japanese journal of pharmacology 1995;68(1):103-10.
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1995: Takeuchi K; Okabe S
Mechanism of gastric alkaline response in the stomach after damage. Roles of nitric oxide and prostaglandins.
Digestive diseases and sciences 1995;40(4):865-71.
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1995: Narita M; Okabe S
Enhanced gastric mucosal damage in rats after chronic treatment with sodium taurocholate.
Japanese journal of pharmacology 1995;67(4):391-4.
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1995: Narita M; Takahashi S; Takeuchi K; Okabe S
Desensitization of capsaicin-sensitive sensory neurons in rat stomachs on chronic treatment with sodium taurocholate.
Japanese journal of pharmacology 1995;67(4):321-8.
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1995: Takeuchi K; Ohuchi T; Okabe S
Effects of nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester on duodenal alkaline secretory and ulcerogenic responses induced by mepirizole in rats.
Digestive diseases and sciences 1995;40(3):670-7.
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1995: Takeuchi K; Ohuchi T; Harada H; Okabe S
Irritant and protective action of urea-urease ammonia in rat gastric mucosa. Different effects of ammonia and ammonium ion.
Digestive diseases and sciences 1995;40(2):274-81.
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1995: Tachibana M; Takeuchi K; Okabe S
Role of the sympathetic nervous system in gastric functional changes induced by thyrotropin-releasing hormone in rats.
Japanese journal of pharmacology 1995;67(2):157-64.
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1995: Takeuchi K; Takehara K; Kaneko T; Okabe S
Nitric oxide and prostaglandins in regulation of acid secretory response in rat stomach following injury.
The Journal of pharmacology and experimental therapeutics 1995;272(1):357-63.
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1994: Takeuchi K; Ohuchi T; Okabe S
Capsaicin-sensitive sensory neurons in healing gastric lesions induced by HCl in rats.
Digestive diseases and sciences 1994;39(12):2543-6.
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1994: Takeuchi K; Niida H; Ohuchi T; Okabe S
Influences of urethane anesthesia on indomethacin-induced gastric mucosal lesions in rats. Relation to blood glucose levels.
Digestive diseases and sciences 1994;39(12):2536-42.
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1994: Tsukimi Y; Okabe S
Acceleration of healing of gastric ulcers induced in rats by liquid diet: importance of tissue contraction.
Japanese journal of pharmacology 1994;66(4):405-12.
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1994: Takeuchi K; Takehara K; Okabe S
Mechanisms underlying stimulation of gastroduodenal HCO3- secretion by NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase, in rats.
Japanese journal of pharmacology 1994;66(3):295-302.
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1994: Tsukimi Y; Okabe S
Effect of anterior unilateral vagotomy on healing of kissing gastric ulcers induced in rats.
Japanese journal of pharmacology 1994;66(1):105-14.
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1994: Ueshima K; Takeuchi K; Ohuchi T; Okabe S
Acid secretory and duodenal ulcerogenic responses induced by mepirizole in anesthetized rats. Relation to body temperature.
Digestive diseases and sciences 1994;39(8):1625-32.
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1994: Takeuchi K; Ueshima K; Ohuchi T; Okabe S
The role of capsaicin-sensitive sensory neurons in healing of HCl-induced gastric mucosal lesions in rats.
Gastroenterology 1994;106(6):1524-32.
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1994: Hiramatsu Y; Okabe S
Effect of intraduodenally administered histamine on gastric acid secretion in rats and guinea pigs.
Digestive diseases and sciences 1994;39(4):689-97.
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1994: Takeuchi K; Ueshima K; Ohuchi T; Okabe S
Induction of gastric lesions and hypoglycemic response by food deprivation in streptozotocin-diabetic rats.
Digestive diseases and sciences 1994;39(3):626-34.
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1994: Takeuchi K; Ohuchi T; Okabe S
Endogenous nitric oxide in gastric alkaline response in the rat stomach after damage.
Gastroenterology 1994;106(2):367-74.
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1994: Tsukimi Y; Okabe S
Validity of kissing gastric ulcers induced in rats for screening of antiulcer drugs.
Journal of gastroenterology and hepatology 1994;9 Suppl 1():S60-5.
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1994: Takeuchi K; Ohuchi T; Tachibana M; Okabe S
The mechanism underlying stimulation of gastric HCO3- secretion by the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester in rats.
Journal of gastroenterology and hepatology 1994;9 Suppl 1():S50-4.
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1993: Takeuchi K; Ohuchi T; Narita M; Okabe S
Capsaicin-sensitive sensory nerves in recovery of gastric mucosal integrity after damage by sodium taurocholate in rats.
Japanese journal of pharmacology 1993;63(4):479-85.
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1993: Okabe S; Miyake H
[The state of the art of gastric antisecretory drugs]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1993;102(3):235-44.
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1993: Takeuchi K; Ohuchi T; Miyake H; Okabe S
Stimulation by nitric oxide synthase inhibitors of gastric and duodenal HCO3- secretion in rats.
The Journal of pharmacology and experimental therapeutics 1993;266(3):1512-9.
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1993: Kato S; Takeuchi K; Okabe S
Mechanism by which histamine increases gastric mucosal blood flow in the rat. Role of luminal H+.
Digestive diseases and sciences 1993;38(7):1224-32.
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1993: Ogihara Y; Okabe S
Effect and mechanism of sucralfate on healing of acetic acid-induced gastric ulcers in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1993;44(2):109-18.
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1993: Okabe S; Takagi K; Inoue K
Effect of NC-1300-O-3 on healing of acetic acid-induced gastric ulcers in rats.
Japanese journal of pharmacology 1993;62(1):25-33.
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1993: Ogihara Y; Okabe S
Effects of indomethacin and prednisolone on the different stages of healing of acetic acid-induced gastric ulcers in the rat.
Japanese journal of pharmacology 1993;61(2):133-6.
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1993: Ogihara Y; Okabe S
Mechanism by which indomethacin delays gastric ulcer healing in the rat: inhibited contraction of the ulcer base.
Japanese journal of pharmacology 1993;61(2):123-31.
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1993: Takeuchi K; Ohuchi T; Kato S; Okabe S
Cytoprotective action of L-arginine against HCl-induced gastric injury in rats: involvement of nitric oxide?
Japanese journal of pharmacology 1993;61(1):13-21.
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1993: Takeuchi K; Ohuchi T; Miyake H; Niki S; Okabe S
Effects of nitric oxide synthase inhibitors on duodenal alkaline secretion in anesthetized rats.
European journal of pharmacology 1993;231(1):135-8.
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1993: Takeuchi K; Okada M; Ueshima K; Ohuchi T; Okabe S
Endogenous sulfhydryls in healing gastric mucosal injury induced by HCl in the rat.
Digestion 1993;54(2):91-7.
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1993: Takeuchi K; Ohuchi T; Matsumoto J; Okabe S
Regulation of gastroduodenal bicarbonate secretion by capsaicin-sensitive sensory neurons in rats.
Journal of clinical gastroenterology 1993;17 Suppl 1():S33-9.
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1992: Takeuchi K; Ohuchi T; Miyake H; Sugawara H; Okabe S
Effects of nitric oxide synthase inhibitors on gastric alkaline secretion in rats.
Japanese journal of pharmacology 1992;60(3):303-5.
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1992: Matsumoto J; Takeuchi K; Ueshima K; Okabe S
Role of capsaicin-sensitive afferent neurons in mucosal blood flow response of rat stomach induced by mild irritants.
Digestive diseases and sciences 1992;37(9):1336-44.
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1992: Matsumoto J; Ueshima K; Ohuchi T; Takeuchi K; Okabe S
Induction of gastric lesions by 2-deoxy-D-glucose in rats following chemical ablation of capsaicin-sensitive sensory neurons.
Japanese journal of pharmacology 1992;60(1):43-9.
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1992: Okabe S; Takagi K; Igata H; Kato S; Shimosako K; Yamaji Y; Seiki M
Effects of a new histamine H2-receptor antagonist, Z-300, on gastric secretion and gastro-duodenal lesions in rats: comparison with roxatidine.
Japanese journal of pharmacology 1992;59(3):275-89.
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1992: Okabe S; Nakaji S; Tachibana M
Effect of ketotifen on acute gastric lesions and gastric secretion in rats.
Japanese journal of pharmacology 1992;59(2):251-4.
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1992: Takeuchi K; Tachibana K; Ueshima K; Matsumoto J; Okabe S
Stimulation by capsaicin of gastric alkaline secretion in anesthetized rats.
Japanese journal of pharmacology 1992;59(2):151-7.
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1992: Takeuchi K; Ueshima K; Matsumoto J; Okabe S
Role of capsaicin-sensitive sensory nerves in acid-induced bicarbonate secretion in rat stomach.
Digestive diseases and sciences 1992;37(5):737-43.
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1992: Okabe S; Narita M; Nakaji S; Takinami Y; Kawano O; Misaki N
[Effects of IGN-2098, a new histamine H2-receptor antagonist, on gastric secretion and gastric and duodenal lesions induced in rats. Comparison with roxatidine]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1992;99(3):167-80.
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1992: Ueshima K; Takeuchi K; Okabe S
Effects of sulfhydryl-related compounds on indomethacin-induced gastric lesions in rats: role of endogenous sulfhydryls in the pathogenesis.
Japanese journal of pharmacology 1992;58(2):157-65.
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1992: Igata H; Okabe S
[Discovery and development of the proton pump inhibitor]
Nippon rinsho. Japanese journal of clinical medicine 1992;50(1):11-7.
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1992: Takeuchi K; Matsumoto J; Ueshima K; Ohuchi T; Okabe S
Induction of duodenal ulcers in sensory deafferented rats following histamine infusion.
Digestion 1992;51(4):203-10.
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1991: Takeuchi K; Niida H; Ueshima K; Okabe S
Effect of YM-14673, an analogue of thyrotropin-releasing hormone, on duodenal bicarbonate secretion in the rat.
Archives internationales de pharmacodynamie et de thérapie 1991;314():133-46.
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1991: Takeuchi K; Nishiwaki H; Niida H; Ueshima K; Okabe S
Duodenal ulcers induced by diethyldithiocarbamate, a superoxide dismutase inhibitor, in the rat: role of antioxidative system in the pathogenesis.
Japanese journal of pharmacology 1991;57(3):299-310.
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1991: Takeuchi K; Matsumoto J; Ueshima K; Okabe S
Role of capsaicin-sensitive afferent neurons in alkaline secretory response to luminal acid in the rat duodenum.
Gastroenterology 1991;101(4):954-61.
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1991: Matsumoto J; Takeuchi K; Okabe S
Characterization of gastric mucosal blood flow response induced by intragastric capsaicin in rats.
Japanese journal of pharmacology 1991;57(2):205-13.
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1991: Takeuchi K; Okada M; Niida H; Okabe S
Dual effects of N-ethylmaleimide on ethanol-induced gastric lesions in rats.
Digestive diseases and sciences 1991;36(7):870-9.
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1991: Niida H; Takeuchi K; Okabe S
Role of thyrotropin-releasing hormone in acid secretory response induced by lowering of body temperature in the rat.
European journal of pharmacology 1991;198(2-3):137-42.
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1991: Hirose H; Takeuchi K; Okabe S
Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats.
Gastroenterology 1991;100(5 Pt 1):1259-65.
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1991: Okabe S; Akimoto Y; Yamasaki S; Kuwahara K
Effects of a new benzimidazole derivative, NC-1300-O-3, on gastric secretion and gastroduodenal lesions in rats.
Japanese journal of pharmacology 1991;55(4):477-91.
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1991: Niida H; Takeuchi K; Ueshima K; Okabe S
Vagally mediated acid hypersecretion and lesion formation in anesthetized rat under hypothermic conditions.
Digestive diseases and sciences 1991;36(4):441-8.
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1991: Takeuchi K; Ueshima K; Okabe S
Stimulation of gastric bicarbonate secretion by an analog of thyrotropin-releasing hormone, YM-14673, in the rat.
The Journal of pharmacology and experimental therapeutics 1991;256(3):1057-62.
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1991: Matsumoto J; Ueshima K; Takeuchi K; Okabe S
Capsaicin-sensitive afferent neurons in adaptive responses of the rat stomach induced by a mild irritant.
Japanese journal of pharmacology 1991;55(1):181-5.
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1991: Takeuchi K; Niida H; Matsumoto J; Ueshima K; Okabe S
Gastric motility changes in capsaicin-induced cytoprotection in the rat stomach.
Japanese journal of pharmacology 1991;55(1):147-55.
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1991: Takeuchi K; Ueshima K; Hironaka Y; Fujioka Y; Matsumoto J; Okabe S
Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Relation to gastric hypermotility.
Digestion 1991;49(3):175-84.
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1990: Ishida Y; Ogihara Y; Okabe S
Effects of a crude extract of a marine dinoflagellate, containing dimethyl-beta-propiothetin, on HCl.ethanol-induced gastric lesions and gastric secretion in rats.
Japanese journal of pharmacology 1990;54(3):333-8.
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1990: Takeuchi K; Niida H; Ueshima K; Okabe S
Determination of gastroduodenal alkaline responses in the rat.
Journal of pharmacological methods 1990;24(3):189-202.
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1990: Takeuchi K; Tanaka T; Wakabayashi S; Mochizuki S; Tomiyama A; Okabe S
Effects of topical application of KT1-32 on transmucosal potential difference and acid secretion in the rat stomach.
Japanese journal of pharmacology 1990;54(2):227-35.
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1990: Wang J Y; Nagai H; Okabe S
Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats.
Japanese journal of pharmacology 1990;54(1):82-5.
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1990: Takeuchi K; Okada M; Niida H; Okabe S
Possible mechanisms involved in gastric hypermotility caused by indomethacin in the rat. Role of glycoprivic response.
Digestive diseases and sciences 1990;35(8):984-92.
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1990: Takeuchi K; Niida H; Okabe S
Characterization of alkaline response induced by cholinergic agents in the rat duodenum: involvement of M2 receptors and the calcium-dependent process.
The Journal of pharmacology and experimental therapeutics 1990;254(2):465-70.
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1990: Shimohara K; Niida H; Okabe S
Effects of KB-5492, 1-(3,4,5-trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl) p iperazine monofumarate monohydrate, on gastric lesions and gastric secretion in rats.
Japanese journal of pharmacology 1990;53(2):275-9.
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1990: Takeuchi K; Niida H; Takinami Y; Okabe S
Stimulation by prostaglandin E2 of alkaline secretion in the rat duodenum: comparative study with hypertonic NaCl.
Japanese journal of pharmacology 1990;53(1):67-74.
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1990: Okabe S; Nishida T; Igata H; Takagi K
[Effects of IT-066, a new histamine H2-receptor antagonist, on gastric acid secretion and experimental gastric ulcers in rats and dogs]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1990;95(5):247-56.
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1990: Takeuchi K; Nishiwaki H; Niida H; Okabe S
Body temperature-dependent action of baclofen in rat stomach. Relation to acid secretion and ulcerogenicity.
Digestive diseases and sciences 1990;35(4):458-66.
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1990: Takeuchi K; Furukawa O; Okada M; Niida H; Okabe S
Influences of stress on gastric alkaline secretion in rats.
The Journal of pharmacology and experimental therapeutics 1990;252(3):1228-33.
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1990: Takeuchi K; Nishiwaki H; Niida H; Okabe S
Different effects of cytoprotective drugs on ethanol- and aspirin-induced gastric mucosal injury in pylorus-ligated rats.
Digestive diseases and sciences 1990;35(2):178-85.
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1990: Takeuchi K; Niida H; Minami M; Okabe S
Determination of bicarbonate output using pH deflection in the rat duodenum: influences of prostaglandins and cholinergic agents.
Japanese journal of pharmacology 1990;52(2):225-32.
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1990: Kuwahara Y; Sunagawa Y; Imoto Y; Okabe S
Effects of orally administered human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats.
Japanese journal of pharmacology 1990;52(1):164-6.
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1990: Tanaka H; Takeuchi K; Okabe S
Role of accumulated gastric content in the pathogenesis of cysteamine- and mepirizole-induced duodenal ulcers in the rat.
Journal of internal medicine. Supplement 1990;732():69-75.
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1990: Okabe S; Takeuchi K; Niida H; Takinami Y
Effects of TY-10957, a stable PGI2 derivative, on gastroduodenal lesions and secretory responses in the rat.
Digestion 1990;45(2):61-71.
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1989: Tanaka H; Takeuchi K; Okabe S; Murakami M
Pathogenesis of the earliest epithelial cell damage induced by mepirizole and cysteamine in the rat duodenum.
Japanese journal of pharmacology 1989;51(4):509-19.
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1989: Tanaka H; Takeuchi K; Okabe S
The relationship of intraduodenal pH and delayed gastric emptying in duodenal ulceration induced by mepirizole or cysteamine in rats.
Japanese journal of pharmacology 1989;51(4):483-92.
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1989: Tanaka H; Takeuchi K; Okabe S
Histamine-induced villous damage in the rat duodenum.
Japanese journal of pharmacology 1989;51(2):291-7.
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1989: Takeuchi K; Nishiwaki H; Okada M; Niida H; Okabe S
Bilateral adrenalectomy worsens gastric mucosal lesions induced by indomethacin in the rat. Role of enhanced gastric motility.
Gastroenterology 1989;97(2):284-93.
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1989: Okabe S; Miyake H; Yamasaki S
Effects of NC-1300, a gastric proton pump inhibitor, on healing of acetic acid-induced gastric ulcers in rats.
Digestive diseases and sciences 1989;34(7):1035-42.
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1989: Okada M; Niida H; Takeuchi K; Okabe S
Role of prostaglandin deficiency in pathogenetic mechanism of gastric lesions induced by indomethacin in rats.
Digestive diseases and sciences 1989;34(5):694-702.
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1989: Okabe S; Takeuchi K; Okada M; Kumadaki Y; Nakata M; Nakata H
[Effects of nizatidine, a new histamine H2-receptor antagonist, on gastric acid secretion and various gastric and duodenal lesions in rats: comparison with cimetidine]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 1989;93(3):133-44.
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1989: Takeuchi K; Okada M; Niida H; Okabe S
Role of sulfhydryls in mucosal injury caused by ethanol: relation to microvascular permeability, gastric motility and cytoprotection.
The Journal of pharmacology and experimental therapeutics 1989;248(2):836-41.
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1989: Nishiwaki H; Takeuchi K; Okada M; Tanaka H; Okabe S
Stimulation of gastric alkaline secretion by histamine in rats: possible involvement of histamine H2-receptors and endogenous prostaglandins.
The Journal of pharmacology and experimental therapeutics 1989;248(2):793-8.
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1989: Tanaka H; Nakagawa M; Takeuchi K; Okabe S
Effects of mepirizole and basic antiinflammatory drugs on HCl-ethanol-induced gastric lesions in rats.
Digestive diseases and sciences 1989;34(2):238-45.
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1989: Wang J Y; Yamasaki S; Takeuchi K; Okabe S
Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin.
Gastroenterology 1989;96(2 Pt 1):393-402.
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1989: Takeuchi K; Ishihara Y; Okada M; Niida H; Okabe S
A continuous monitoring of mucosal integrity and secretory activity in rat stomach: a preparation using a lucite chamber.
Japanese journal of pharmacology 1989;49(2):235-44.
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1989: Nishiwaki H; Okada M; Hara N; Takeuchi K; Okabe S
Mechanisms involved in aggravation of ethanol-induced gastric mucosal lesions in adrenalectomized rats.
Japanese journal of pharmacology 1989;49(1):27-35.
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1989: Takeuchi K; Okada M; Niida H; Okabe S
Healing process of duodenal ulcers induced by indomethacin plus histamine in rats.
Digestion 1989;42(4):202-11.
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1989: Kuwahara Y; Okabe S
Effects of human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats.
Scandinavian journal of gastroenterology. Supplement 1989;162():162-5.
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1989: Tanaka H; Takeuchi K; Okabe S
Effects of the duodenal ulcerogens, mepirizole and cysteamine, on gastric motility and emptying in rats.
Scandinavian journal of gastroenterology. Supplement 1989;162():104-7.
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1989: Niida H; Okada M; Takeuchi K; Okabe S
A new model of duodenal ulcers induced in rats by diethyldithiocarbamate, a superoxide dismutase inhibitor.
Scandinavian journal of gastroenterology. Supplement 1989;162():116-9.
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1988: Takeuchi K; Nishiwaki H; Hara N; Okabe S
Effects of gastric distension and prostaglandin on acid ethanol-induced mucosal lesions in the rat.
Digestive diseases and sciences 1988;33(12):1569-77.
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1988: Takeuchi K; Nishiwaki H; Okabe S
Effects of dopamine on gastric mucosal lesions induced by ethanol in rats. Possible involvement of antigastric motor activity mediated with alpha 2-adrenoceptors.
Digestive diseases and sciences 1988;33(12):1560-8.
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1988: Takeuchi K; Nobuhara Y; Tanaka H; Nishiwaki H; Okabe S
Effects of hemorrhagic shock on alkaline secretion and mucosal tolerance to acid in rat duodenum. A comparative study with indomethacin.
Digestive diseases and sciences 1988;33(11):1409-17.
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1988: Okabe S; Akimoto Y; Yamasaki S; Nagai H
Effects of NC-1300-B, a new benzimidazole derivative, on hog gastric H+, K+-ATPase, gastric acid secretion and HCl.ethanol-induced gastric lesions in rats.
Digestive diseases and sciences 1988;33(11):1425-34.
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1988: Takeuchi K; Nishiwaki H; Okabe S
Effects of topical application of acidified omeprazole on acid secretion and transmucosal potential difference in anesthetized rat stomachs.
Japanese journal of pharmacology 1988;47(4):397-408.
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1988: Furukawa O; Takeuchi K; Nishiwaki H; Okabe S
Pathogenesis of digitoxin-induced duodenal ulcers in pregnant rats. Roles of gastric acid and duodenal alkaline secretion.
Digestive diseases and sciences 1988;33(7):889-96.
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1988: Wang J Y; Takeuchi K; Okabe S
Dissolution of antisecretory and cytoprotective action of PGE2 in rats.
Japanese journal of pharmacology 1988;47(1):103-5.
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1988: Takeuchi K; Nishiwaki H; Okada M; Okabe S
Mucosal protective action of histamine against gastric lesions induced by HCl in rats: importance of antigastric motor activity mediated by H2-receptors.
The Journal of pharmacology and experimental therapeutics 1988;245(2):632-8.
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1988: Ueki S; Takeuchi K; Okabe S
Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats.
Digestive diseases and sciences 1988;33(2):209-16.
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1988: Takeuchi K; Nishiwaki H; Osano H; Ebara S; Okabe S
Repair of mucosal damage induced by ethanol in the rat stomach. Effects of concentration, exposure period and prostaglandins.
Digestion 1988;40(1):1-10.
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1988: Takeuchi K; Furukawa O; Okada M; Okabe S
Duodenal ulcers induced by indomethacin plus histamine in the dog. Involvement of the impaired duodenal alkaline secretion in their pathogenesis.
Digestion 1988;39(4):230-40.
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1988: Ohno T; Okabe S
Gastric surface epithelial cell damage induced by restraint and water-immersion stress in rats. Protective effects of 16,16-dimethyl-prostaglandin E2.
Journal of clinical gastroenterology 1988;10 Suppl 1():S46-52.
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1987: Takeuchi K; Furukawa O; Nishiwaki H; Okabe S
16,16-Dimethyl prostaglandin E2 aggravates gastric mucosal injury induced by histamine in rats. Possible role of the increased mucosal vascular permeability.
Gastroenterology 1987;93(6):1276-86.
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1987: Ohno T; Nakagawa M; Nishimura S; Takeuchi K; Okabe S
Effect of 16,16-dimethyl prostaglandin E2 on gastric surface epithelial cell damage induced by 20% ethanol in rats.
Japanese journal of pharmacology 1987;45(3):327-34.
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1987: Takeuchi K; Nishiwaki H; Furukawa O; Okabe S
Cytoprotective action of histamine against 0.6 N HCl-induced gastric mucosal injury in rats; comparative study with adaptive cytoprotection induced by exogenous acid.
Japanese journal of pharmacology 1987;44(3):335-44.
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1987: Takeuchi K; Nishiwaki H; Ishihara Y; Okabe S
Roles of gastric motility changes in cytoprotection induced by acetazolamide and cysteamine in rats.
Japanese journal of pharmacology 1987;44(3):269-81.
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1987: Takeuchi K; Furukawa O; Tanaka H; Nishiwaki H; Okabe S
Impairment of acid-neutralizing capacity and lesion formation in the rat duodenum during hemorrhagic shock: comparative study with indomethacin.
Japanese journal of pharmacology 1987;44(2):163-70.
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