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Seiji Okada

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Hiroki Goto; Yuki Kojima; Hirokazu Nagai; Seiji Okada
Establishment of a CD4-positive cell line from an AIDS-related primary effusion lymphoma.
Hiroki Goto; Shinichiro Hattori; Ryusho Kariya; Harutaka Katano; Kouki Matsuda; Pattaravadee Srikoon; Manabu Taura; Seiji Okada
Potent antitumor activity of zoledronic acid-induced Vγ9Vδ2 T cells against primary effusion lymphoma.
Eriko Kudo; Kouki Matsuda; Masako Shimamoto; Manabu Taura; Hiroki Goto; Shinichiro Hattori; Ryusho Kariya; Shinya Kimura; Seiji Okada
Inhibition of HIV-1 replication by a tricyclic coumarin GUT-70 in acutely and chronically infected cells.

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All Publications

2013: Hiroki Goto; Yuki Kojima; Hirokazu Nagai; Seiji Okada
Establishment of a CD4-positive cell line from an AIDS-related primary effusion lymphoma.
International journal of hematology 2013;97(5):624-33.
2013: Hiroki Goto; Shinichiro Hattori; Ryusho Kariya; Harutaka Katano; Kouki Matsuda; Pattaravadee Srikoon; Manabu Taura; Seiji Okada
Potent antitumor activity of zoledronic acid-induced Vγ9Vδ2 T cells against primary effusion lymphoma.
Cancer letters 2013;331(2):174-82.
2013: Eriko Kudo; Kouki Matsuda; Masako Shimamoto; Manabu Taura; Hiroki Goto; Shinichiro Hattori; Ryusho Kariya; Shinya Kimura; Seiji Okada
Inhibition of HIV-1 replication by a tricyclic coumarin GUT-70 in acutely and chronically infected cells.
Bioorganic & medicinal chemistry letters 2013;23(3):606-9.
2012: Suchada Phimsen; Andri Rezano; Taiji Suda; Shigenobu Tone; Kulthida Vaeteewoottacharn; Masahiro Kitabatake; Kazuhiko Kuwahara; Teruo Nakaya; Kazutaka Ohta; Seiji Okada; Nobuo Sakaguchi
Selective cell death of p53-insufficient cancer cells is induced by knockdown of the mRNA export molecule GANP.
Apoptosis : an international journal on programmed cell death 2012;17(7):679-90.
2012: Takashi Chihara; Nopporn Chutiwitoonchai; Michihiro Hashimoto; Masateru Hiyoshi; Yuka Hiyoshi-Yoshidomi; Seiji Okada; Abu Osman; Ikuko Suzu; Shinya Suzu
HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(8):3620-7.
2012: Motoyoshi Endo; Shigetomo Fukuhara; Masahiko Harada; Tai Hato; Tsunekazu Hishima; Haruki Horiguchi; Hirotoshi Horio; Takaaki Ito; Hirotaka Iwase; Tsuyoshi Kadomatsu; Hiroaki Kuroda; Tetsuro Masuda; Shuji Mikami; Takashi Minami; Keishi Miyata; Naoki Mochizuki; Masahiro Nakano; Hiroaki Nomori; Haruki Odagiri; Seiji Okada; Takashi Takahashi; Yutaka Yamamoto; Jun Aoi; Yuichi Oike
Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis.
Cancer research 2012;72(7):1784-94.
2012: Hiroki Goto; Ryusho Kariya; Harutaka Katano; Eriko Kudo; Masako Shimamoto; Manabu Taura; Seiji Okada
Antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-κB pathway.
Cancer science 2012;103(4):775-81.
2012: Takashi Matsuno; Shingo Matsuyama; Saori Morino-Koga; Yuka Okamoto; Yuichiro Shimauchi; Tsuyoshi Shuto; Mary Ann Suico; Manabu Taura; Shuichiro Yano; Hirofumi Kai; Ryusho Kariya; Seiji Okada
Diethyldithiocarbamate induces apoptosis in HHV-8-infected primary effusion lymphoma cells via inhibition of the NF-κB pathway.
International journal of oncology 2012;40(4):1071-8.
2012: Yang Xi; Yuko Hino; Yuko Nakatsu; Seiji Okada; Chiyomi Sakamoto; Sugiko Watanabe; Mitsuyoshi Nakao
Hmga1 is differentially expressed and mediates silencing of the CD4/CD8 loci in T cell lineages and leukemic cells.
Cancer science 2012;103(3):439-47.
2012: Masateru Hiyoshi; Nobuhiro Nakamura; Masato Okada; Seiji Okada; Takashi Chihara; Nopporn Chutiwitoonchai; Naoko Takahashi-Makise; Yuka Yoshidomi; Shinya Suzu
HIV-1 Nef perturbs the function, structure, and signaling of the Golgi through the Src kinase Hck.
Journal of cellular physiology 2012;227(3):1090-7.
2012: Manthana Michai; Hiroki Goto; Shinichiro Hattori; Kulthida Vaeteewoottacharn; Chaisiri Wongkham; Sopit Wongkham; Seiji Okada
Soluble CD30: a possible serum tumor marker for primary effusion lymphoma.
Asian Pacific journal of cancer prevention : APJCP 2012;13(10):4939-41.
2011: Nopporn Chutiwitoonchai; Oliver T Fackler; Masateru Hiyoshi; Philip Mwimanzi; Hirotaka Ode; Seiji Okada; Hironori Sato; Akio Adachi; Takamasa Ueno; Shinya Suzu
The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement.
PloS one 2011;6(11):e27696.
2011: Ayumi Ono; Shinichiro Hattori; Ryusho Kariya; Sumako Iwanaga; Manabu Taura; Hideki Harada; Shinya Suzu; Seiji Okada
Comparative study of human hematopoietic cell engraftment into BALB/c and C57BL/6 strain of rag-2/jak3 double-deficient mice.
Journal of biomedicine & biotechnology 2011;2011():539748.
2011: Manabu Taura; Mary Ann Suico; Ryosuke Fukuda; Tomoaki Koga; Tsuyoshi Shuto; T Sato; Saori Morino-Koga; Seiji Okada; Hirofumi Kai
MEF/ELF4 transactivation by E2F1 is inhibited by p53.
Nucleic acids research 2011;39(1):76-88.
2010: T Chihara; Shinya Suzu; R Hassan; N Chutiwitoonchai; Masateru Hiyoshi; Kazuo Motoyoshi; F Kimura; Seiji Okada
IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation.
Cell death and differentiation 2010;17(12):1917-27.
2010: Masaaki Satoh; Makoto Saito; Kohsuke Tanaka; Sumako Iwanaga; Salem Nagla Elwy Salem Ali; Takahiro Seki; Seiji Okada; Michinori Kohara; Shinji Harada; Chieko Kai; Kyoko Tsukiyama-Kohara
Evaluation of a recombinant measles virus expressing hepatitis C virus envelope proteins by infection of human PBL-NOD/Scid/Jak3null mouse.
Comparative immunology, microbiology and infectious diseases 2010;33(6):e81-8.
2010: Shogo Shimasaki; Tomoaki Koga; Tsuyoshi Shuto; Mary Ann Suico; T Sato; Kenji Watanabe; Saori Morino-Koga; Manabu Taura; Seiji Okada; Kazutoshi Mori; Hirofumi Kai
Endoplasmic reticulum stress increases the expression and function of toll-like receptor-2 in epithelial cells.
Biochemical and biophysical research communications 2010;402(2):235-40.
2010: Omar Dessouki; Yasuyuki Kamiya; Hiroyasu Nagahama; Motohiko Tanaka; Shinya Suzu; Yutaka Sasaki; Seiji Okada
Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment.
Biochemical and biophysical research communications 2010;393(2):331-7.
2010: Seiji Okada
[Recent advances in the treatment of AIDS-related malignant lymphoma].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(3):491-6.
2009: Ranya Hassan; Shinya Suzu; Masateru Hiyoshi; Naoko Takahashi-Makise; Takamasa Ueno; Tsutomu Agatsuma; Hirofumi Akari; Jun Komano; Yutaka Takebe; Kazuo Motoyoshi; Seiji Okada
Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms.
Journal of cellular physiology 2009;221(2):458-68.
2009: Naoko Takahashi-Makise; Shinya Suzu; Masateru Hiyoshi; Takeo Ohsugi; Harutaka Katano; Kazuo Umezawa; Seiji Okada
Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF-kappaB pathway.
International journal of cancer. Journal international du cancer 2009;125(6):1464-72.
2009: Shinichiro Hattori; Kazuhiko Ide; Hirotomo Nakata; Hideki Harada; Shinya Suzu; Noriyuki Ashida; Satoru Kohgo; Hiroyuki Hayakawa; Hiroaki Mitsuya; Seiji Okada
Potent activity of a nucleoside reverse transcriptase inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice.
Antimicrobial agents and chemotherapy 2009;53(9):3887-93.
2008: Toru Murakami; Hideki Harada; Mary Ann Suico; Tsuyoshi Shuto; Shinya Suzu; Hirofumi Kai; Seiji Okada
Ephedrae herba, a component of Japanese herbal medicine Mao-to, efficiently activates the replication of latent human immunodeficiency virus type 1 (HIV-1) in a monocytic cell line.
Biological & pharmaceutical bulletin 2008;31(12):2334-7.
2008: Seiji Okada; Hideki Harada; Takaaki Ito; Takashi Saito; Shinya Suzu
Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34 + cells.
International journal of hematology 2008;88(5):476-82.
2008: Masateru Hiyoshi; Shinya Suzu; Yuka Yoshidomi; Ranya Hassan; Hideki Harada; Naomi Sakashita; Hirofumi Akari; Kazuo Motoyoshi; Seiji Okada
Interaction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor.
Blood 2008;111(1):243-50.
2007: Hideki Harada; Toru Murakami; Seow Shi Tea; Akira Takeuchi; Tomoaki Koga; Seiji Okada; Mary Ann Suico; Tsuyoshi Shuto; Hirofumi Kai
Heat shock suppresses human NK cell cytotoxicity via regulation of perforin.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2007;23(8):657-65.
2007: Kazumi Yamamoto; Shinya Suzu; Yuka Yoshidomi; Masateru Hiyoshi; Hideki Harada; Seiji Okada
Erythroblasts highly express the ABC transporter Bcrp1/ABCG2 but do not show the side population (SP) phenotype.
Immunology letters 2007;114(1):52-8.
2007: Takeo Ohsugi; Toshio Kumasaka; Seiji Okada; Takaomi Ishida; Kazunari Yamaguchi; Ryouichi Horie; Toshiki Watanabe; Kazuo Umezawa
Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with tax-deficient adult T-cell leukemia-derived cell lines.
Cancer letters 2007;257(2):206-15.
2007: Hideki Harada; Yumi Goto; Tadao Ohno; Shinya Suzu; Seiji Okada
Proliferative activation up-regulates expression of CD4 and HIV-1 co-receptors on NK cells and induces their infection with HIV-1.
European journal of immunology 2007;37(8):2148-55.
2007: Shinya Suzu; Masateru Hiyoshi; Yuka Yoshidomi; Hideki Harada; Motohiro Takeya; Fumihiko Kimura; Kazuo Motoyoshi; Seiji Okada
M-CSF-mediated macrophage differentiation but not proliferation is correlated with increased and prolonged ERK activation.
Journal of cellular physiology 2007;212(2):519-25.
2007: Takeo Ohsugi; Toshio Kumasaka; Seiji Okada; Toru Urano
The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells.
Nature medicine 2007;13(5):527-8.
2007: Kousuke Numata; Masato Kubo; Hiroyuki Watanabe; Katsumasa Takagi; Hiroshi Mizuta; Seiji Okada; Steven Kunkel; Takaaki Ito; Akihiro Matsukawa
Overexpression of suppressor of cytokine signaling-3 in T cells exacerbates acetaminophen-induced hepatotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3777-85.
2007: Ikuo Nobuhisa; Naoki Ohtsu; Seiji Okada; Naomi Nakagata; Tetsuya Taga
Identification of a population of cells with hematopoietic stem cell properties in mouse aorta-gonad-mesonephros cultures.
Experimental cell research 2007;313(5):965-74.
2006: Hiroyuki Watanabe; Masato Kubo; Kousuke Numata; Katsumasa Takagi; Hiroshi Mizuta; Seiji Okada; Takaaki Ito; Akihiro Matsukawa
Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8650-7.
2005: Tomoaki Koga; Hideki Harada; Tea Seow Shi; Seiji Okada; Mary Ann Suico; Tsuyoshi Shuto; Hirofumi Kai
Hyperthermia suppresses the cytotoxicity of NK cells via down-regulation of perforin/granzyme B expression.
Biochemical and biophysical research communications 2005;337(4):1319-23.
2005: Hideki Harada; Shinya Suzu; Takaaki Ito; Seiji Okada
Selective expansion and engraftment of human CD16+ NK cells in NOD/SCID mice.
European journal of immunology 2005;35(12):3599-609.
2005: Hideki Harada; Shinya Suzu; Yokichi Hayashi; Seiji Okada
BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule.
Journal of cellular physiology 2005;204(3):919-26.
2005: Shinya Suzu; Hideki Harada; Takahiro Matsumoto; Seiji Okada
HIV-1 Nef interferes with M-CSF receptor signaling through Hck activation and inhibits M-CSF bioactivities.
Blood 2005;105(8):3230-7.
2001: Takeshi Miyamoto; Osamu Ohneda; Fumio Arai; K Iwamoto; Seiji Okada; K Takagi; DM Anderson; Toshio Suda
Bifurcation of osteoclasts and dendritic cells from common progenitors.
Blood 2001;98(8):2544-54.