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Brydon Bennett

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Chemicals & Drugs

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Nicole Reich; Georg Schett; Michal Tomcik; Weilin Xie; Pawel Zerr; Alfiya Akhmetshina; Jérome Avouac; Brydon L Bennett; Christian Beyer; Clara Dees; Oliver Distler; Angelika Horn; Veronika Lang; Katrin Palumbo; Jörg H W Distler
Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis.
Andy K H Lim; Frank Yuanfang Ma; David J Nikolic-Paterson; Elyce Ozols; Brydon L Bennett; Glenn C Friedman; Morag J Young; Gregory H Tesch
Evaluation of JNK blockade as an early intervention treatment for type 1 diabetic nephropathy in hypertensive rats.
John Kanellis; Frank Y Ma; Rangi Kandane-Rathnayake; John P Dowling; Kevan R Polkinghorne; Brydon L Bennett; Glenn C Friedman; David J Nikolic-Paterson
JNK signalling in human and experimental renal ischaemia/reperfusion injury.

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All Publications

2012: Nicole Reich; Georg Schett; Michal Tomcik; Weilin Xie; Pawel Zerr; Alfiya Akhmetshina; Jérome Avouac; Brydon L Bennett; Christian Beyer; Clara Dees; Oliver Distler; Angelika Horn; Veronika Lang; Katrin Palumbo; Jörg H W Distler
Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis.
Annals of the rheumatic diseases 2012;71(5):737-45.
2011: Andy K H Lim; Frank Yuanfang Ma; David J Nikolic-Paterson; Elyce Ozols; Brydon L Bennett; Glenn C Friedman; Morag J Young; Gregory H Tesch
Evaluation of JNK blockade as an early intervention treatment for type 1 diabetic nephropathy in hypertensive rats.
American journal of nephrology 2011;34(4):337-46.
2010: John Kanellis; Frank Y Ma; Rangi Kandane-Rathnayake; John P Dowling; Kevan R Polkinghorne; Brydon L Bennett; Glenn C Friedman; David J Nikolic-Paterson
JNK signalling in human and experimental renal ischaemia/reperfusion injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010;25(9):2898-908.
2009: Yibing Xu; Jianwu Li; Gregory D Ferguson; Frank Mercurio; Gody Khambatta; Lisa Morrison; Antonia Lopez-Girona; Laura G Corral; David R Webb; Brydon L Bennett; Weilin Xie
Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases.
Blood 2009;114(2):338-45.
2009: Frank Yuanfang Ma; Robert S Flanc; Gregory H Tesch; Brydon L Bennett; Glenn C Friedman; David J Nikolic-Paterson
Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat.
Laboratory investigation; a journal of technical methods and pathology 2009;89(4):470-84.
2008: Weiming Xu; Maria Celeridad; Sabita Sankar; David R Webb; Brydon L Bennett
CC-4047 promotes Th1 cell differentiation and reprograms polarized human Th2 cells by enhancing transcription factor T-bet.
Clinical immunology (Orlando, Fla.) 2008;128(3):392-9.
2007: Robert S Flanc; Frank Yuanfang Ma; Gregory H Tesch; Y Han; Robert C Atkins; Brydon L Bennett; G C Friedman; J-H Fan; David J Nikolic-Paterson
A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis.
Kidney international 2007;72(6):698-708.
2007: Alison Williams; Razao Issa; Sum-Yee Leung; Puneeta Nath; Gregory D Ferguson; Brydon L Bennett; Ian M Adcock; K Fan Chung
Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125.
The Journal of pharmacology and experimental therapeutics 2007;322(1):351-9.
2007: Akihiro Tabata; Masayuki Morikawa; Masahiro Miyajima; Brydon L Bennett; Yoshitaka Satoh; Jianhua Huang; Yasuaki Tamura; Noriyuki Sato; Tomio Abe
Suppression of alloreactivity and allograft rejection by SP600125, a small molecule inhibitor of c-Jun N-terminal kinase.
Transplantation 2007;83(10):1358-64.
2007: Frank Yuanfang Ma; Robert S Flanc; Gregory H Tesch; Yingjie Han; Robert C Atkins; Brydon L Bennett; Glenn C Friedman; Jui-Hsiang Fan; David J Nikolic-Paterson
A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.
Journal of the American Society of Nephrology : JASN 2007;18(2):472-84.
2006: Keiichi Mitsuyama; Asuka Suzuki; Nobuo Tomiyasu; Osamu Tsuruta; Shigehiko Kitazaki; Teiko Takeda; Yoshitaka Satoh; Brydon L Bennett; Atsushi Toyonaga; Michio Sata
Pro-inflammatory signaling by Jun-N-terminal kinase in inflammatory bowel disease.
International journal of molecular medicine 2006;17(3):449-55.
2006: Keiichi Mitsuyama; Osamu Tsuruta; Y Matsui; K Harada; Nobuo Tomiyasu; Asuka Suzuki; Kosuke Takaki; Junya Masuda; Kazuyo Handa; Y Satoh; Brydon L Bennett; Atsushi Toyonaga; Michio Sata
Activation of c-Jun N-terminal kinase (JNK) signalling in experimentally induced gastric lesions in rats.
Clinical and experimental immunology 2006;143(1):24-9.
2005: Puneeta Nath; PAUL EYNOTT; Sum-Yee Leung; Ian M Adcock; Brydon L Bennett; K Fan Chung
Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125.
European journal of pharmacology 2005;506(3):273-83.
2004: PAUL EYNOTT; Li Xu; Brydon L Bennett; Alistair Noble; Sum-Yee Leung; Puneeta Nath; David A Groneberg; Ian M Adcock; K Fan Chung
Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats.
Immunology 2004;112(3):446-53.
2004: Robert F Schwabe; Hiroshi Uchinami; Ting Qian; Brydon L Bennett; John J Lemasters; David A Brenner
Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(6):720-2.
2004: Lihua Du; Christopher S Lyle; Toria B Obey; William A Gaarde; Jeffrey A Muir; Brydon L Bennett; Timothy C Chambers
Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent.
The Journal of biological chemistry 2004;279(12):11957-66.
2003: PAUL EYNOTT; Puneeta Nath; Sum-Yee Leung; Ian M Adcock; Brydon L Bennett; K Fan Chung
Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N-terminal kinase.
British journal of pharmacology 2003;140(8):1373-80.
2003: Moorthy S S Palanki; Paul E Erdman; Minghuan Ren; Mark Suto; Brydon L Bennett; Anthony Manning; Lynn J Ransone; Cheryl Spooner; Sonal Desai; Arnie Ow; Ryuichi Totsuka; Peter Tsao; Wataru Toriumi
The design and synthesis of novel orally active inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. SAR of in vitro and in vivo studies.
Bioorganic & medicinal chemistry letters 2003;13(22):4077-80.
2003: Brydon L Bennett; Yoshitaka Satoh; Alan J Lewis
JNK: a new therapeutic target for diabetes.
Current opinion in pharmacology 2003;3(4):420-5.
2003: Jerome B Zeldis; Peter H Schafer; Brydon L Bennett; Frank Mercurio; David I Stirling
Potential new therapeutics for Waldenstrom's macroglobulinemia.
Seminars in oncology 2003;30(2):275-81.
2003: Robert F Schwabe; Cynthia A Bradham; Tetsuya Uehara; Etsuro Hatano; Brydon L Bennett; Robert Schoonhoven; David A Brenner
c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration.
Hepatology (Baltimore, Md.) 2003;37(4):824-32.
2002: Maria P Russo; Brydon L Bennett; Anthony Manning; David A Brenner; Christian Jobin
Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas.
American journal of physiology. Cell physiology 2002;283(1):C347-57.
2001: KR Aupperle; Y Yamanishi; Brydon L Bennett; Frank Mercurio; David L Boyle; Gary S Firestein
Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes.
Cellular immunology 2001;214(1):54-9.
2001: Brydon L Bennett; D T Sasaki; BW Murray; Eoin O'Leary; S T Sakata; W Xu; J C Leisten; A Motiwala; S Pierce; Y Satoh; Shripad S Bhagwat; Anthony Manning; David W Anderson
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13681-6.
2001: Bernd Schnabl; Cynthia A Bradham; Brydon L Bennett; Anthony Manning; Branko Stefanovic; David A Brenner
TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells.
Hepatology (Baltimore, Md.) 2001;34(5):953-63.
2001: Paul P Tak; Danielle M Gerlag; KR Aupperle; D A van de Geest; Maria J Overbeek; Brydon L Bennett; David L Boyle; Anthony Manning; Gary S Firestein
Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation.
Arthritis and rheumatism 2001;44(8):1897-907.
2001: Etsuro Hatano; Brydon L Bennett; Anthony Manning; Ting Qian; John J Lemasters; David A Brenner
NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis.
Gastroenterology 2001;120(5):1251-62.
2001: BW Murray; Brydon L Bennett; D T Sasaki
Analysis of pharmacologic inhibitors of Jun N-terminal kinases.
Methods in enzymology 2001;332():432-52.
2001: Robert F Schwabe; Brydon L Bennett; Anthony Manning; David A Brenner
Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes.
Hepatology (Baltimore, Md.) 2001;33(1):81-90.
2000: Moorthy S S Palanki; Paul E Erdman; Leah M Gayo-Fung; Graziella I Shevlin; R W Sullivan; ME Goldman; Lynn J Ransone; Brydon L Bennett; Anthony Manning; Mark Suto
Inhibitors of NF-kappaB and AP-1 gene expression: SAR studies on the pyrimidine portion of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis(trifluoromethyl)phenyl)carboxamide].
Journal of medicinal chemistry 2000;43(21):3995-4004.
1999: A Khoshnan; SJ Kempiak; Brydon L Bennett; David Bae; W Xu; Anthony Manning; Carl H June; Andre E Nel
Primary human CD4+ T cells contain heterogeneous I kappa B kinase complexes: role in activation of the IL-2 promoter.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5444-52.
1999: KR Aupperle; Brydon L Bennett; David L Boyle; Paul P Tak; Anthony Manning; Gary S Firestein
NF-kappa B regulation by I kappa B kinase in primary fibroblast-like synoviocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):427-33.
1999: Frank Mercurio; BW Murray; A Shevchenko; Brydon L Bennett; David B Young; J W Li; G Pascual; A Motiwala; H Zhu; M Mann; Anthony Manning
IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex.
Molecular and cellular biology 1999;19(2):1526-38.
1998: M A O'Connell; Brydon L Bennett; Frank Mercurio; Anthony Manning; Nigel Mackman
Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells.
The Journal of biological chemistry 1998;273(46):30410-4.
1998: M Paulose; Brydon L Bennett; Anthony Manning; Karim Essani
Selective inhibition of TNF-alpha induced cell adhesion molecule gene expression by tanapox virus.
Microbial pathogenesis 1998;25(1):33-41.
1997: Frank Mercurio; H Zhu; BW Murray; A Shevchenko; Brydon L Bennett; J Li; David B Young; M Barbosa; M Mann; Anthony Manning; A Rao
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
Science (New York, N.Y.) 1997;278(5339):860-6.
1997: Brydon L Bennett; R Cruz; Raul Lacson; Anthony Manning
Interleukin-4 suppression of tumor necrosis factor alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB.
The Journal of biological chemistry 1997;272(15):10212-9.
1996: Brydon L Bennett; Raul Lacson; C C Chen; R Cruz; J S Wheeler; R F Kletzien; A G Tomasselli; R L Heinrikson; Anthony Manning
Identification of signal-induced IkappaB-alpha kinases in human endothelial cells.
The Journal of biological chemistry 1996;271(33):19680-8.