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Kenji Okajima

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Naoaki Harada; Hiroki Kurihara; Naomi Nakagata; Juan Zhao; Kenji Okajima
Resveratrol improves cognitive function in mice by increasing production of insulin-like growth factor-I in the hippocampus.
Naoaki Harada; Hiroki Kurihara; Kenji Okajima; Juan Zhao; Naomi Nakagata
Retraction: Stimulation of FcγRI on primary sensory neurons increases insulin-like growth factor-I production, thereby reducing reperfusion-induced renal injury in mice.
Kenji Okajima; Chen Ren; Naoaki Harada
[Acute lung injury/acute respiratory distress syndrome: progress in diagnosis and treatment. Topics: IV. Recent topics: 1. New therapeutic agents for ARDS].

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2011: Naoaki Harada; Hiroki Kurihara; Naomi Nakagata; Juan Zhao; Kenji Okajima
Resveratrol improves cognitive function in mice by increasing production of insulin-like growth factor-I in the hippocampus.
The Journal of nutritional biochemistry 2011;22(12):1150-9.
2011: Naoaki Harada; Hiroki Kurihara; Kenji Okajima; Juan Zhao; Naomi Nakagata
Retraction: Stimulation of FcγRI on primary sensory neurons increases insulin-like growth factor-I production, thereby reducing reperfusion-induced renal injury in mice.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(6):3448.
2011: Kenji Okajima; Chen Ren; Naoaki Harada
[Acute lung injury/acute respiratory distress syndrome: progress in diagnosis and treatment. Topics: IV. Recent topics: 1. New therapeutic agents for ARDS].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2011;100(6):1599-606.
2011: Juan Zhao; Naoaki Harada; Hiroki Kurihara; Naomi Nakagata; Kenji Okajima
Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice.
The Journal of nutritional biochemistry 2011;22(3):227-33.
2010: Naoaki Harada; Juan Zhao; Hiroki Kurihara; Naomi Nakagata; Kenji Okajima
Stimulation of Fc gammaRI on primary sensory neurons increases insulin-like growth factor-I production, thereby reducing reperfusion-induced renal injury in mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(2):1303-10.
2010: Masatoku Arai; Mitsuhiro Uchiba; Hidefumi Komura; Yuichiro Mizuochi; Naoaki Harada; Kenji Okajima
Metformin, an antidiabetic agent, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro.
The Journal of pharmacology and experimental therapeutics 2010;334(1):206-13.
2010: Miho Kawai; Naoaki Harada; Hiromitsu Takeyama; Kenji Okajima
Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats.
Translational research : the journal of laboratory and clinical medicine 2010;155(6):294-304.
2010: Juan Zhao; Naoaki Harada; Hiroki Kurihara; Naomi Nakagata; Kenji Okajima
Cilostazol improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus.
Neuropharmacology 2010;58(4-5):774-83.
2010: Naoaki Harada; Juan Zhao; Hiroki Kurihara; Naomi Nakagata; Kenji Okajima
Effects of topical application of alpha-D-glucosylglycerol on dermal levels of insulin-like growth factor-i in mice and on facial skin elasticity in humans.
Bioscience, biotechnology, and biochemistry 2010;74(4):759-65.
2009: Naoaki Harada; Nobuhiko Shimozawa; Kenji Okajima
AT(1) receptor blockers increase insulin-like growth factor-I production by stimulating sensory neurons in spontaneously hypertensive rats.
Translational research : the journal of laboratory and clinical medicine 2009;154(3):142-52.
2009: Naoaki Harada; Noriko Narimatsu; Hiroki Kurihara; Naomi Nakagata; Kenji Okajima
Stimulation of sensory neurons improves cognitive function by promoting the hippocampal production of insulin-like growth factor-I in mice.
Translational research : the journal of laboratory and clinical medicine 2009;154(2):90-102.
2009: Noriko Narimatsu; Naoaki Harada; Hiroki Kurihara; Naomi Nakagata; Kazuya Sobue; Kenji Okajima
Donepezil improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus.
The Journal of pharmacology and experimental therapeutics 2009;330(1):2-12.
2009: Naoaki Harada; Kenji Okajima
Effects of capsaicin and isoflavone on blood pressure and serum levels of insulin-like growth factor-I in normotensive and hypertensive volunteers with alopecia.
Bioscience, biotechnology, and biochemistry 2009;73(6):1456-9.
2009: Juan Zhao; Naoaki Harada; Kazuya Sobue; Hirotada Katsuya; Kenji Okajima
Insulin-like growth factor-I reduces stress-induced gastric mucosal injury by inhibiting neutrophil activation in mice.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2009;19(2):136-45.
2008: Naoaki Harada; Kenji Okajima; Hirotaka Isobe
Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats.
Shock (Augusta, Ga.) 2008;30(4):379-87.
2008: Naoaki Harada; Kenji Okajima; Noriko Narimatsu; Hiroki Kurihara; Naomi Nakagata
Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2008;18(4):335-44.
2008: Kenji Okajima
[Regulation of inflammatory responses by endothelial cells--understanding the molecular mechanism(s) and its therapeutic application to sepsis].
Masui. The Japanese journal of anesthesiology 2008;57(3):311-20.
2008: Naoaki Harada; Kenji Okajima; Hiroki Kurihara; Naomi Nakagata
Antithrombin prevents reperfusion-induced hepatic apoptosis by enhancing insulin-like growth factor-I production in mice.
Critical care medicine 2008;36(3):971-4.
2008: Hidefumi Komura; Mitsuhiro Uchiba; Y Mizuochi; M Arai; Naoaki Harada; Hirotada Katsuya; Kenji Okajima
Antithrombin inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by monocytes in vitro through inhibition of Egr-1 expression.
Journal of thrombosis and haemostasis : JTH 2008;6(3):499-507.
2008: Naoaki Harada; Kenji Okajima
Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2008;18(1):75-81.
2007: Naoaki Harada; Kenji Okajima; Masatoku Arai; Hiroki Kurihara; Naomi Nakagata
Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2007;17(5):408-15.
2007: Takuya Nakayama; Naoaki Harada; Miki Asano; Norikazu Nomura; Takayuki Saito; Akira Mishima; Kenji Okajima
Atrial natriuretic peptide reduces ischemia/reperfusion-induced spinal cord injury in rats by enhancing sensory neuron activation.
The Journal of pharmacology and experimental therapeutics 2007;322(2):582-90.
2007: Yuichiro Mizuochi; Kenji Okajima; Naoaki Harada; Perenlei Molor-Erdene; Mitsuhiro Uchiba; Hidefumi Komura; Takako Tsuda; Hirotada Katsuya
Carvedilol, a nonselective beta-blocker, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro.
Translational research : the journal of laboratory and clinical medicine 2007;149(4):223-30.
2007: Naoaki Harada; Kenji Okajima; Hiroki Kurihara; Naomi Nakagata
Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I, thereby reducing reperfusion-induced apoptosis in mice.
Neuropharmacology 2007;52(5):1303-11.
2007: Naoaki Harada; Kenji Okajima
Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2007;17(2):171-6.
2007: Kenji Okajima
[Multiple organ failure associated with severe infection--the molecular mechanism (s) and new therapeutic strategies].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 3():619-26.
2007: Kenji Okajima; Naoaki Harada; Takao Nakagawa
[Role of endothelial dysfunction in the development of severe sepsis--the pathomechanism, evaluation by laboratory tests and new therapeutic strategies].
Rinsho byori. The Japanese journal of clinical pathology 2007;55(3):280-9.
2007: Naoaki Harada; Kenji Okajima
Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats.
Digestive diseases and sciences 2007;52(2):469-77.
2007: Naoaki Harada; Kenji Okajima; Hidefumi Kohmura; Mitsuhiro Uchiba; Tsutomu Tomita
Danaparoid sodium reduces ischemia/reperfusion-induced liver injury in rats by attenuating inflammatory responses.
Thrombosis and haemostasis 2007;97(1):81-7.
2006: Naoaki Harada; Yuji Taoka; Kenji Okajima
Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats.
Journal of neurotrauma 2006;23(12):1739-49.
2006: Kenji Okajima; Naoaki Harada; George Sakurai; Yukihiro Soga; Hiroyasu Suga; Takahiro Terada; Takao Nakagawa
Rapid assay for plasma soluble E-selectin predicts the development of acute respiratory distress syndrome in patients with systemic inflammatory response syndrome.
Translational research : the journal of laboratory and clinical medicine 2006;148(6):295-300.
2006: Nobuhiko Shimozawa; Kenji Okajima; Naoaki Harada; Masatoku Arai; Yusuke Ishida; Shoichi Shimada; Hiroki Kurihara; Naomi Nakagata
Contribution of sensory neurons to sex difference in the development of stress-induced gastric mucosal injury in mice.
Gastroenterology 2006;131(6):1826-34.
2006: Naoaki Harada; Kenji Okajima; Mitsuhiro Uchiba
Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats.
Critical care medicine 2006;34(7):1883-91.
2006: Naoaki Harada; Kenji Okajima; Hirotaka Isobe; Mitsuhiro Uchiba
Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats.
Thrombosis and haemostasis 2006;95(6):1011-8.
2006: Naoaki Harada; Kenji Okajima; Mitsuhiro Uchiba; Hiroki Kurihara; Naomi Nakagata
Antithrombin reduces reperfusion-induced liver injury in mice by enhancing sensory neuron activation.
Thrombosis and haemostasis 2006;95(5):788-95.
2006: Kenji Okajima; Naoaki Harada
Regulation of inflammatory responses by sensory neurons: molecular mechanism(s) and possible therapeutic applications.
Current medicinal chemistry 2006;13(19):2241-51.
2005: Naoaki Harada; Kenji Okajima; Wenge Liu
Rebamipide decreases the susceptibility of gastric mucosa to acid-induced injury in rats by inhibiting neutrophil activation.
Digestive diseases and sciences 2005;50 Suppl 1():S56-62.
2005: Perenlei Molor-Erdene; Kenji Okajima; Hirotaka Isobe; Mitsuhiro Uchiba; Naoaki Harada; Nobuhiko Shimozawa; Hiroaki Okabe
Inhibition of lipopolysaccharide-induced tissue factor expression in monocytes by urinary trypsin inhibitor in vitro and in vivo.
Thrombosis and haemostasis 2005;94(1):136-45.
2005: Kenji Okajima; Hirotaka Isobe; Mitsuhiro Uchiba; Naoaki Harada
Role of sensory neuron in reduction of endotoxin-induced hypotension in rats.
Critical care medicine 2005;33(4):847-54.
2005: Perenlei Molor-Erdene; Kenji Okajima; Hirotaka Isobe; Mitsuhiro Uchiba; Naoaki Harada; Hiroaki Okabe
Urinary trypsin inhibitor reduces LPS-induced hypotension by suppressing tumor necrosis factor-alpha production through inhibition of Egr-1 expression.
American journal of physiology. Heart and circulatory physiology 2005;288(3):H1265-71.
2005: Naoaki Harada; Kenji Okajima; Mehtap Yuksel; Hirotaka Isobe
Contribution of capsaicin-sensitive sensory neurons to antithrombin-induced reduction of ischemia/reperfusion-induced liver injury in rats.
Thrombosis and haemostasis 2005;93(1):48-56.
2004: Yuji Taoka; Kenji Okajima; Mitsuhiro Uchiba
Antithrombin reduces compression-induced spinal cord injury in rats.
Journal of neurotrauma 2004;21(12):1818-30.
2004: Mitsuhiro Uchiba; Kenji Okajima
[Fibrinopeptide A (FPA), fibrinopeptide B (FPB) and fibrinopeptide Bbeta(15-42) (FPBbeta15-42)].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 12():615-7.
2004: Mitsuhiro Uchiba; Kenji Okajima; Christoph Kaun; Johann Wojta; Bernd R Binder
Inhibition of the endothelial cell activation by antithrombin in vitro.
Thrombosis and haemostasis 2004;92(6):1420-7.
2004: Kenji Okajima; Naoaki Harada; Mitsuhiro Uchiba; Masakazu Mori
Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats.
American journal of physiology. Gastrointestinal and liver physiology 2004;287(6):G1116-23.
2004: Naoaki Harada; Kenji Okajima; Mitsuhiro Uchiba; Shigeki Kushimoto; Hirotaka Isobe
Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-1.
Thrombosis and haemostasis 2004;92(3):550-8.
2004: Mitsuhiro Uchiba; Kenji Okajima; Yuichi Oike; Yasuhiro Ito; Kenji Fukudome; Hirotaka Isobe; Toshio Suda
Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo.
Circulation research 2004;95(1):34-41.
2004: Kenji Okajima; Naoaki Harada; Mitsuhiro Uchiba; Hirotaka Isobe
Activation of capsaicin-sensitive sensory neurons by carvedilol, a nonselective beta-blocker, in spontaneous hypertensive rats.
The Journal of pharmacology and experimental therapeutics 2004;309(2):684-91.
2004: Kenji Okajima
Prevention of endothelial cell injury by activated protein C: the molecular mechanism(s) and therapeutic implications.
Current vascular pharmacology 2004;2(2):125-33.
2004: Kenji Okajima
Regulation of inflammatory responses by activated protein C: the molecular mechanism(s) and therapeutic implications.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2004;42(2):132-41.
2004: Hirotaka Isobe; Kenji Okajima; Naoaki Harada; Wenge Liu; Hiroaki Okabe
Activated protein C reduces stress-induced gastric mucosal injury in rats by inhibiting the endothelial cell injury.
Journal of thrombosis and haemostasis : JTH 2004;2(2):313-20.
2004: Koji Hirose; Kenji Okajima; Mitsuhiro Uchiba; Kan-yu Nakano; Junichi Utoh; Nobuo Kitamura
Antithrombin reduces the ischemia/reperfusion-induced spinal cord injury in rats by attenuating inflammatory responses.
Thrombosis and haemostasis 2004;91(1):162-70.
2003: Tomohiro Sakamoto; Hisao Ogawa; Keiji Takazoe; Michihiro Yoshimura; Hideki Shimomura; Yasushi Moriyama; Hidekazu Arai; Kenji Okajima
Effect of activated protein C on plasma plasminogen activator inhibitor activity in patients with acute myocardial infarction treated with alteplase: comparison with unfractionated heparin.
Journal of the American College of Cardiology 2003;42(8):1389-94.
2003: Mitsuhiro Uchiba; Kenji Okajima; Christoph Kaun; Bernd R Binder; Johann Wojta
Gabexate mesilate, a synthetic anticoagulant, inhibits the expression of endothelial leukocyte adhesion molecules in vitro.
Critical care medicine 2003;31(4):1147-53.
2003: Mehtap Yuksel; Kenji Okajima; Mitsuhiro Uchiba; Hiroaki Okabe
Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes.
The Journal of pharmacology and experimental therapeutics 2003;305(1):298-305.
2003: Kenji Okajima
[Sepsis and multi-organ failure].
Nihon rinsho. Japanese journal of clinical medicine 2003;61 Suppl 3():319-24.
2003: Seiichiro Naruo; Kenji Okajima; Yuji Taoka; Mitsuhiro Uchiba; Takafumi Nakamura; Hiroaki Okabe; Katsumasa Takagi
Prostaglandin E1 reduces compression trauma-induced spinal cord injury in rats mainly by inhibiting neutrophil activation.
Journal of neurotrauma 2003;20(2):221-8.
2002: Kenji Okajima; Naoaki Harada; Shigeki Kushimoto; Mitsuhiro Uchiba
Role of microthrombus formation in the development of ischemia/reperfusion-induced liver injury in rats.
Thrombosis and haemostasis 2002;88(3):473-80.
2002: Mehtap Yuksel; Kenji Okajima; Mitsuhiro Uchiba; Seikoh Horiuchi; Hiroaki Okabe
Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes.
Thrombosis and haemostasis 2002;88(2):267-73.
2002: Kenji Okajima; Naoaki Harada; Mitsuhiro Uchiba
Ranitidine reduces ischemia/reperfusion-induced liver injury in rats by inhibiting neutrophil activation.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1157-65.
2002: Naoaki Harada; Kenji Okajima; Mitsuhiro Uchiba; Takeshi Katsuragi
Ischemia/reperfusion-induced increase in the hepatic level of prostacyclin is mainly mediated by activation of capsaicin-sensitive sensory neurons in rats.
The Journal of laboratory and clinical medicine 2002;139(4):218-26.
2002: Kenji Okajima
[Standardization of the laboratory method for antithrombin activity measurement].
Rinsho byori. The Japanese journal of clinical pathology 2002;50(3):283-6.
2002: Hirotaka Isobe; Kenji Okajima; Mitsuhiro Uchiba; Naoaki Harada; Hiroaki Okabe
Antithrombin prevents endotoxin-induced hypotension by inhibiting the induction of nitric oxide synthase in rats.
Blood 2002;99(5):1638-45.
2001: Kenji Okajima
Regulation of inflammatory responses by natural anticoagulants.
Immunological reviews 2001;184():258-74.
2001: P Enkhbaatar; Kenji Okajima; Mitsuhiro Uchiba; Hirotaka Isobe; Hiroaki Okabe
Recombinant tissue factor pathway inhibitor prevents lipopolysaccharide-induced systemic hypotension in rats by inhibiting excessive production of nitric oxide.
Thrombosis and haemostasis 2001;86(6):1573-7.
2001: Hirotaka Isobe; Kenji Okajima; Mitsuhiro Uchiba; A Mizutani; Naoaki Harada; A Nagasaki; Kazutoshi Okabe
Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide.
Circulation 2001;104(10):1171-5.
2001: Yuji Taoka; Kenji Okajima; Mitsuhiro Uchiba; M Johno
Methylprednisolone reduces spinal cord injury in rats without affecting tumor necrosis factor-alpha production.
Journal of neurotrauma 2001;18(5):533-43.
2001: Kenji Okajima
[Molecular markers for the blood coagulation and fibrinolysis].
Rinsho byori. The Japanese journal of clinical pathology 2001;Suppl 115():74-90.
2000: Kenji Okajima; Y Sakamoto; Mitsuhiro Uchiba
Heterogeneity in the incidence and clinical manifestations of disseminated intravascular coagulation: a study of 204 cases.
American journal of hematology 2000;65(3):215-22.
2000: P Enkhbaatar; Kenji Okajima; K Murakami; Mitsuhiro Uchiba; Hiroaki Okabe; Kazutoshi Okabe; Yoshihiro Yamaguchi
Recombinant tissue factor pathway inhibitor reduces lipopolysaccharide-induced pulmonary vascular injury by inhibiting leukocyte activation.
American journal of respiratory and critical care medicine 2000;162(5):1752-9.
2000: Kenji Okajima; K Murakami; Wenge Liu; Mitsuhiro Uchiba
Inhibition of neutrophil activation by ranitidine contributes to prevent stress-induced gastric mucosal injury in rats.
Critical care medicine 2000;28(8):2858-65.
2000: K Hirose; Kenji Okajima; Yuji Taoka; Mitsuhiro Uchiba; H Tagami; K Nakano; Junichi Utoh; Hiroaki Okabe; N Kitamura
Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation.
Annals of surgery 2000;232(2):272-80.
2000: Kenji Okajima
[SIRS and the coagulation of normality].
Rinsho byori. The Japanese journal of clinical pathology 2000;48(6):510-5.
2000: Naoaki Harada; Kenji Okajima; Wenge Liu; Mitsuhiro Uchiba
Activated neutrophils impair gastric cytoprotection role of neutrophil elastase.
Digestive diseases and sciences 2000;45(6):1210-6.
2000: Mitsuhiro Uchiba; Kenji Okajima
[Endothelial cells and coagulation abnormalities].
Rinsho byori. The Japanese journal of clinical pathology 2000;48(4):308-13.
2000: Yuji Taoka; Kenji Okajima
Role of leukocytes in spinal cord injury in rats.
Journal of neurotrauma 2000;17(3):219-29.
2000: Yuji Taoka; Kenji Okajima; Mitsuhiro Uchiba; M Johno
Neuroprotection by recombinant thrombomodulin.
Thrombosis and haemostasis 2000;83(3):462-8.
2000: K Murakami; Kenji Okajima; Mitsuhiro Uchiba
The prevention of lipopolysaccharide-induced pulmonary vascular injury by pretreatment with cepharanthine in rats.
American journal of respiratory and critical care medicine 2000;161(1):57-63.
1999: Kenji Okajima
[Antithrombin].
Nihon rinsho. Japanese journal of clinical medicine 1999;57 Suppl():582-4.
1999: Naoaki Harada; Kenji Okajima; Shigeki Kushimoto
Gabexate mesilate, a synthetic protease inhibitor, reduces ischemia/reperfusion injury of rat liver by inhibiting leukocyte activation.
Critical care medicine 1999;27(9):1958-64.
1999: Naoaki Harada; Kenji Okajima; K Murakami; Hirotaka Isobe; Wenge Liu
Gastric prostacyclin (PGI2) prevents stress-induced gastric mucosal injury in rats primarily by inhibiting leukocyte activation.
Prostaglandins & other lipid mediators 1999;57(5-6):291-303.
1999: Hirotaka Isobe; Kenji Okajima; Wenge Liu; Naoaki Harada
Antithrombin prevents stress-induced gastric mucosal injury by increasing the gastric prostacyclin level in rats.
The Journal of laboratory and clinical medicine 1999;133(6):557-65.
1999: K Murakami; Kenji Okajima; Naoaki Harada; Hirotaka Isobe; Wenge Liu; M Johno; Hiroaki Okabe
Plaunotol prevents indomethacin-induced gastric mucosal injury in rats by inhibiting neutrophil activation.
Alimentary pharmacology & therapeutics 1999;13(4):521-30.
1999: Naoaki Harada; Kenji Okajima; Shigeki Kushimoto; Hirotaka Isobe; K Tanaka
Antithrombin reduces ischemia/reperfusion injury of rat liver by increasing the hepatic level of prostacyclin.
Blood 1999;93(1):157-64.
1998: Wenge Liu; Kenji Okajima; K Murakami; Naoaki Harada; Hirotaka Isobe; T Irie
Role of neutrophil elastase in stress-induced gastric mucosal injury in rats.
The Journal of laboratory and clinical medicine 1998;132(5):432-9.
1998: Yuji Taoka; Kenji Okajima
Spinal cord injury in the rat.
Progress in neurobiology 1998;56(3):341-58.
1998: K Murakami; Kenji Okajima; Naoaki Harada; Hirotaka Isobe; Hiroaki Okabe
Rebamipide prevents indomethacin-induced gastric mucosal lesion formation by inhibiting activation of neutrophils in rats.
Digestive diseases and sciences 1998;43(9 Suppl):139S-142S.
1998: Yuji Taoka; Kenji Okajima; K Murakami; M Johno; M Naruo
Role of neutrophil elastase in compression-induced spinal cord injury in rats.
Brain research 1998;799(2):264-9.
1998: Kenji Okajima
Antithrombin prevents endotoxin-induced pulmonary vascular injury by inhibiting leukocyte activation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1998;9 Suppl 2():S25-37.
1998: Mitsuhiro Uchiba; Kenji Okajima; K Murakami
Effects of various doses of antithrombin III on endotoxin-induced endothelial cell injury and coagulation abnormalities in rats.
Thrombosis research 1998;89(5):233-41.
1998: Yuji Taoka; Kenji Okajima; Mitsuhiro Uchiba; K Murakami; Naoaki Harada; M Johno; M Naruo
Activated protein C reduces the severity of compression-induced spinal cord injury in rats by inhibiting activation of leukocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(4):1393-8.
1998: Kenji Okajima; Mitsuhiro Uchiba
The anti-inflammatory properties of antithrombin III: new therapeutic implications.
Seminars in thrombosis and hemostasis 1998;24(1):27-32.
1997: Mitsuhiro Uchiba; Kenji Okajima; K Murakami; Hiroaki Okabe; S Okamoto; Y Okada
Effects of plasma kallikrein specific inhibitor and active-site blocked factor VIIa on the pulmonary vascular injury induced by endotoxin in rats.
Thrombosis and haemostasis 1997;78(4):1209-14.
1997: Mitsuhiro Uchiba; Kenji Okajima; K Murakami; M Johno; M Mohri; Hiroaki Okabe; Kiyoshi Takatsuki
rhs-TM prevents ET-induced increase in pulmonary vascular permeability through protein C activation.
The American journal of physiology 1997;273(4 Pt 1):L889-94.
1997: K Murakami; Kenji Okajima; Mitsuhiro Uchiba; Naoaki Harada; Wenge Liu; Hiroaki Okabe; Kiyoshi Takatsuki
Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats.
The Journal of laboratory and clinical medicine 1997;130(3):307-13.
1997: Yuji Taoka; Kenji Okajima; Mitsuhiro Uchiba; K Murakami; Shigeki Kushimoto; M Johno; M Naruo; Hiroaki Okabe; Kiyoshi Takatsuki
Role of neutrophils in spinal cord injury in the rat.
Neuroscience 1997;79(4):1177-82.
1997: Yuji Taoka; Kenji Okajima; Mitsuhiro Uchiba; K Murakami; Naoaki Harada; M Johno; M Naruo; Hiroaki Okabe; Kiyoshi Takatsuki
Reduction of spinal cord injury by administration of iloprost, a stable prostacyclin analog.
Journal of neurosurgery 1997;86(6):1007-11.
1997: Yuji Taoka; Kenji Okajima; Mitsuhiro Uchiba; K Murakami; Shigeki Kushimoto; M Johno; M Naruo; Hiroaki Okabe; Kiyoshi Takatsuki
Gabexate mesilate, a synthetic protease inhibitor, prevents compression-induced spinal cord injury by inhibiting activation of leukocytes in rats.
Critical care medicine 1997;25(5):874-9.
1997: Yoshihiro Yamaguchi; N Hisama; Kenji Okajima; Mitsuhiro Uchiba; K Murakami; Y Takahashi; Shinwa Yamada; Katsutaka Mori; Michio Ogawa
Pretreatment with activated protein C or active human urinary thrombomodulin attenuates the production of cytokine-induced neutrophil chemoattractant following ischemia/reperfusion in rat liver.
Hepatology (Baltimore, Md.) 1997;25(5):1136-40.
1997: Kenji Okajima; Mitsuhiro Uchiba; K Murakami; Hiroaki Okabe; Kiyoshi Takatsuki
Plasma levels of soluble E-selectin in patients with disseminated intravascular coagulation.
American journal of hematology 1997;54(3):219-24.
1997: K Murakami; Kenji Okajima; Mitsuhiro Uchiba; M Johno; Tomohiro Nakagaki; Hiroaki Okabe; Kiyoshi Takatsuki
Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production.
The American journal of physiology 1997;272(2 Pt 1):L197-202.
1997: K Murakami; Kenji Okajima; Mitsuhiro Uchiba; Naoaki Harada; M Johno; Hiroaki Okabe; Kiyoshi Takatsuki
Rebamipide attenuates indomethacin-induced gastric mucosal lesion formation by inhibiting activation of leukocytes in rats.
Digestive diseases and sciences 1997;42(2):319-25.
1997: Mitsuhiro Uchiba; Kenji Okajima; K Murakami; M Johno; Hiroaki Okabe; Kiyoshi Takatsuki
Effect of human urinary thrombomodulin on endotoxin-induced intravascular coagulation and pulmonary vascular injury in rats.
American journal of hematology 1997;54(2):118-23.
1997: Mitsuhiro Uchiba; Kenji Okajima; K Murakami; Hiroaki Okabe; K Takatsuki
Effect of nafamostat mesilate on pulmonary vascular injury induced by lipopolysaccharide in rats.
American journal of respiratory and critical care medicine 1997;155(2):711-8.
1997: Mitsuhiro Uchiba; Kenji Okajima
Antithrombin III (AT III) prevents LPS-induced pulmonary vascular injury: novel biological activity of AT III.
Seminars in thrombosis and hemostasis 1997;23(6):583-90.
1996: Shigeki Kushimoto; Kenji Okajima; Mitsuhiro Uchiba; K Murakami; Naoaki Harada; H Okabe; Kiyoshi Takatsuki
Role of granulocyte elastase in ischemia/reperfusion injury of rat liver.
Critical care medicine 1996;24(11):1908-12.
1996: Mitsuhiro Uchiba; Kenji Okajima; K Murakami; M Johno; H Okabe; Kiyoshi Takatsuki
Recombinant thrombomodulin prevents endotoxin-induced lung injury in rats by inhibiting leukocyte activation.
The American journal of physiology 1996;271(3 Pt 1):L470-5.
1996: N Hisama; Yoshihiro Yamaguchi; Kenji Okajima; Mitsuhiro Uchiba; K Murakami; Katsutaka Mori; Shinwa Yamada; M Ogawa
Anticoagulant pretreatment attenuates production of cytokine-induced neutrophil chemoattractant following ischemia-reperfusion of rat liver.
Digestive diseases and sciences 1996;41(7):1481-6.
1996: K Murakami; Kenji Okajima; Mitsuhiro Uchiba; M Johno; H Okabe; Kiyoshi Takatsuki
A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats.
Thrombosis and haemostasis 1996;75(6):965-70.
1996: Mitsuhiro Uchiba; Kenji Okajima; K Murakami; H Okabe; Kiyoshi Takatsuki
Attenuation of endotoxin-induced pulmonary vascular injury by antithrombin III.
The American journal of physiology 1996;270(6 Pt 1):L921-30.
1996: K Murakami; Kenji Okajima; Mitsuhiro Uchiba; H Okabe; Kiyoshi Takatsuki
Gabexate mesilate, a synthetic protease inhibitor, attenuates endotoxin-induced pulmonary vascular injury by inhibiting tumor necrosis factor production by monocytes.
Critical care medicine 1996;24(6):1047-53.
1996: Shigeki Kushimoto; Kenji Okajima; H Okabe; B R Binder
Role of granulocyte elastase in the formation of hemorrhagic shock-induced gastric mucosal lesions in the rat.
Critical care medicine 1996;24(6):1041-6.
1996: S Hirai; T Kageshita; T Kimura; M Tsujisaki; Kenji Okajima; K Imai; Tomomichi Ono
Soluble intercellular adhesion molecule-1 and soluble E-selectin levels in patients with atopic dermatitis.
The British journal of dermatology 1996;134(4):657-61.
1996: Shigeki Kushimoto; Kenji Okajima; Mitsuhiro Uchiba; K Murakami; H Okabe; Kiyoshi Takatsuki
Pulmonary vascular injury induced by hemorrhagic shock is mediated by P-selectin in rats.
Thrombosis research 1996;82(1):97-106.
1996: Kenji Okajima; Mitsuhiro Uchiba; K Murakami; H Okabe; Kiyoshi Takatsuki
Determination of plasma soluble fibrin using a new ELISA method in patients with disseminated intravascular coagulation.
American journal of hematology 1996;51(3):186-91.
1996: K Murakami; Kenji Okajima; Mitsuhiro Uchiba; M Johno; Tomohiro Nakagaki; H Okabe; Kiyoshi Takatsuki
Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats.
Blood 1996;87(2):642-7.
1995: Mitsuhiro Uchiba; Kenji Okajima; K Murakami; K Nawa; H Okabe; Kiyoshi Takatsuki
Recombinant human soluble thrombomodulin reduces endotoxin-induced pulmonary vascular injury via protein C activation in rats.
Thrombosis and haemostasis 1995;74(5):1265-70.
1995: Mitsuhiro Uchiba; Kenji Okajima; K Murakami; H Okabe; Kiyoshi Takatsuki
Effects of antithrombin III (AT III) and Trp49-modified AT III on plasma level of 6-keto-PGF1 alpha in rats.
Thrombosis research 1995;80(3):201-8.
1995: Kenji Okajima; H Abe; B R Binder
Endothelial cell injury induced by plasmin in vitro.
The Journal of laboratory and clinical medicine 1995;126(4):377-84.
1995: Mitsuhiro Uchiba; Kenji Okajima; K Murakami; H Okabe; Kiyoshi Takatsuki
Endotoxin-induced pulmonary vascular injury is mainly mediated by activated neutrophils in rats.
Thrombosis research 1995;78(2):117-25.
1995: K Murakami; Kenji Okajima; K Sakata; Kiyoshi Takatsuki
[A possible mechanism of interstitial pneumonia during interferon therapy with sho-saiko-to].
Nihon Kyōbu Shikkan Gakkai zasshi 1995;33(4):389-94.
1995: Kenji Okajima
[Antithrombin III (AT III)].
Nihon rinsho. Japanese journal of clinical medicine 1995;53 Su Pt 2():43-7.
1995: K Murakami; Kenji Okajima; H Okabe
[Catalase].
Nihon rinsho. Japanese journal of clinical medicine 1995;53 Su Pt 1():358-60.
1995: Kenji Okajima; H Abe; M Wagatsuma; H Okabe; Kiyoshi Takatsuki
Antithrombin III Kumamoto II; a single mutation at Arg393-His increased the affinity of antithrombin III for heparin.
American journal of hematology 1995;48(1):12-8.
1994: Kenji Okajima; R Fujise; Y Motosato; M Ushijima; H Okabe; Kiyoshi Takatsuki
Plasma levels of granulocyte elastase-alpha 1-proteinase inhibitor complex in patients with disseminated intravascular coagulation: pathophysiologic implications.
American journal of hematology 1994;47(2):82-8.
1994: H Abe; Kenji Okajima; H Okabe; Kiyoshi Takatsuki; B R Binder
Granulocyte proteases and hydrogen peroxide synergistically inactivate thrombomodulin of endothelial cells in vitro.
The Journal of laboratory and clinical medicine 1994;123(6):874-81.
1994: Mitsuhiro Uchiba; Kenji Okajima; H Abe; H Okabe; Kiyoshi Takatsuki
Effect of nafamostat mesilate, a synthetic protease inhibitor, on tissue factor-factor VIIa complex activity.
Thrombosis research 1994;74(2):155-61.
1994: Kenji Okajima; I Kohno; G Soe; H Okabe; Kiyoshi Takatsuki; B R Binder
Direct evidence for systemic fibrinogenolysis in patients with acquired alpha 2-plasmin inhibitor deficiency.
American journal of hematology 1994;45(1):16-24.
1994: Kenji Okajima
[Clinical relevance of determination of plasma ATIII and alpha 2 PI activities in patients with DIC--application of the molecular markers for the analysis of pathophysiology of DIC].
Rinsho byori. The Japanese journal of clinical pathology 1994;42(1):45-55.
1993: Kenji Okajima; H Abe; S Maeda; M Motomura; M Tsujihata; S Nagataki; H Okabe; Kiyoshi Takatsuki
Antithrombin III Nagasaki (Ser116-Pro): a heterozygous variant with defective heparin binding associated with thrombosis.
Blood 1993;81(5):1300-5.
1992: Kenji Okajima; I Kohno; J Tsuruta; H Okabe; Kiyoshi Takatsuki; B R Binder
Direct evidence for systemic fibrinogenolysis in a patient with metastatic prostatic cancer.
Thrombosis research 1992;66(6):717-27.
1991: Kenji Okajima; W P Yang; H Okabe; M Inoue; Kiyoshi Takatsuki
Role of leukocytes in the activation of intravascular coagulation in patients with septicemia.
American journal of hematology 1991;36(4):265-71.
1990: Kenji Okajima; M Inoue; S Koga; H Okabe; Kiyoshi Takatsuki
Plasma polymorphonuclear leukocyte elastase-alpha 1-proteinase inhibitor complex in patients with gastric ulcer.
Clinica chimica acta; international journal of clinical chemistry 1990;189(2):237-41.
1990: Kenji Okajima; H Oyama; K Kimura; K Maeda; S Obata; Y Ogata; H Okabe; S Koga; Kiyoshi Takatsuki
[Plasma concentration of polymorphonuclear leukocyte elastase-alpha 1-proteinase inhibitor complex in patients with gastric ulcer].
Rinsho byori. The Japanese journal of clinical pathology 1990;38(8):901-5.
1990: Kenji Okajima; Mitsuhiro Uchiba; H Okabe; Kiyoshi Takatsuki
[Studies on the role of leukocytes in the activation of intravascular coagulation in septicemia].
Rinsho byori. The Japanese journal of clinical pathology 1990;38(7):799-805.
1990: S Koga; Kenji Okajima; M Inoue; H Okabe; H Araki; S Nagase; Kiyoshi Takatsuki
Dynamic aspects of thrombus formation in mutant analbuminemic rats.
Thrombosis research 1990;58(6):633-43.
1990: H Ueyama; T Murakami; S Nishiguchi; S Maeda; Y Hashimoto; Kenji Okajima; K Shimada; S Araki
Antithrombin III Kumamoto: identification of a point mutation and genotype analysis of the family.
Thrombosis and haemostasis 1990;63(2):231-4.
1990: Kenji Okajima; H Imamura; S Koga; M Inoue; Kiyoshi Takatsuki; N Aoki
Treatment of patients with disseminated intravascular coagulation by protein C.
American journal of hematology 1990;33(4):277-8.
1990: Kenji Okajima; S Koga; M Kaji; M Inoue; Tomohiro Nakagaki; A Funatsu; H Okabe; Kiyoshi Takatsuki; N Aoki
Effect of protein C and activated protein C on coagulation and fibrinolysis in normal human subjects.
Thrombosis and haemostasis 1990;63(1):48-53.
1989: Kenji Okajima; S Koga; Tomohiro Nakagaki; H Okabe; A Funatsu; Kiyoshi Takatsuki
[Role of protein C in endotoxin-induced release of plasminogen activator inhibitor from endothelial cell].
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society 1989;52(7):1159-64.
1989: H Ueyama; Y Hashimoto; Makoto Uchino; Y Sasaki; E Uyama; Kenji Okajima; S Araki
Progressing ischemic stroke in a homozygote with variant antithrombin III.
Stroke; a journal of cerebral circulation 1989;20(6):815-8.
1989: Kenji Okajima; H Ueyama; Y Hashimoto; Y Sasaki; K Matsumoto; H Okabe; M Inoue; S Araki; Kiyoshi Takatsuki
Homozygous variant of antithrombin III that lacks affinity for heparin, AT III Kumamoto.
Thrombosis and haemostasis 1989;61(1):20-4.
1989: Kenji Okajima; S Koga; H Okabe; M Inoue; Kiyoshi Takatsuki
Characterization of the fibrinolytic state by measuring stable cross-linked fibrin degradation products in disseminated intravascular coagulation associated with acute promyelocytic leukemia.
Acta haematologica 1989;81(1):15-8.
1987: M Inoue; Kenji Okajima; K Itoh; Y Ando; N Watanabe; T Yasaka; S Nagase; Y Morino
Mechanism of furosemide resistance in analbuminemic rats and hypoalbuminemic patients.
Kidney international 1987;32(2):198-203.