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Hiroaki Okamoto

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Co-Publications
Name
62
Tsuda, Fumio
58
Takahashi, Masaharu
58
Mayumi, M
56
Miyakawa, Yuzo
43
Nishizawa, Tsutomu
29
Akahane, Yoshihiro
24
Tanaka, T
12
Ukita, M
10
Gotanda, Yuhko
10
Inoue, Jun
10
Mizuo, Hitoshi
10
Masuko, Kazuo
9
Tanaka, Toshinori
8
Tsatsralt-Od, Bira
8
Kishimoto, Junichi

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Publications

TOP 3
Toda Takayuki; Mitsui Takehiro; Tsukamoto Yukie; Ebara Takeshi; Hirose Akinori; Masuko Kazuo; Nagashima Shigeo; Takahashi Masaharu; Okamoto Hiroaki
Molecular analysis of transmission of hepatitis C virus in a nurse who acquired acute hepatitis C after caring for a viremic patient with epistaxis.
Yamada Kentaro; Takahashi Masaharu; Hoshino Yu; Takahashi Hideyuki; Ichiyama Koji; Nagashima Shigeo; Tanaka Toshinori; Okamoto Hiroaki
ORF3 protein of hepatitis E virus is essential for virion release from infected cells.
Toda Takayuki; Mitsui Takehiro; Tsukamoto Yukie; Ebara Takeshi; Masuko Kazuo; Takahashi Masaharu; Okamoto Hiroaki
No evidence for patient-to-patient transmission of hepatitis C virus during upper gastrointestinal endoscopy: molecular studies on three acute hepatitis C patients.

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All Publications

2009: Toda Takayuki; Mitsui Takehiro; Tsukamoto Yukie; Ebara Takeshi; Hirose Akinori; Masuko Kazuo; Nagashima Shigeo; Takahashi Masaharu; Okamoto Hiroaki
Molecular analysis of transmission of hepatitis C virus in a nurse who acquired acute hepatitis C after caring for a viremic patient with epistaxis.
Journal of medical virology 2009;81(8):1363-70.
2009: Yamada Kentaro; Takahashi Masaharu; Hoshino Yu; Takahashi Hideyuki; Ichiyama Koji; Nagashima Shigeo; Tanaka Toshinori; Okamoto Hiroaki
ORF3 protein of hepatitis E virus is essential for virion release from infected cells.
The Journal of general virology 2009;90(Pt 8):1880-91.
2009: Toda Takayuki; Mitsui Takehiro; Tsukamoto Yukie; Ebara Takeshi; Masuko Kazuo; Takahashi Masaharu; Okamoto Hiroaki
No evidence for patient-to-patient transmission of hepatitis C virus during upper gastrointestinal endoscopy: molecular studies on three acute hepatitis C patients.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2009;21(3):147-53.
2009: Tanaka Toshinori; Takahashi Masaharu; Takahashi Hideyuki; Ichiyama Koji; Hoshino Yu; Nagashima Shigeo; Mizuo Hitoshi; Okamoto Hiroaki
Development and characterization of a genotype 4 hepatitis E virus cell culture system using a HE-JF5/15F strain recovered from a fulminant hepatitis patient.
Journal of clinical microbiology 2009;47(6):1906-10.
2009: Okamoto Hiroaki
[Recent advances in hepatitis E: including the development and application of a robust cell culture system for HEV]
Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology 2009;106(2):177-87.
2009: Yamada Kentaro; Takahashi Masaharu; Hoshino Yu; Takahashi Hideyuki; Ichiyama Koji; Tanaka Toshinori; Okamoto Hiroaki
Construction of an infectious cDNA clone of hepatitis E virus strain JE03-1760F that can propagate efficiently in cultured cells.
The Journal of general virology 2009;90(Pt 2):457-62.
2009: Ninomiya Masashi; Takahashi Masaharu; Hoshino Yu; Ichiyama Koji; Simmonds Peter; Okamoto Hiroaki
Analysis of the entire genomes of torque teno midi virus variants in chimpanzees: infrequent cross-species infection between humans and chimpanzees.
The Journal of general virology 2009;90(Pt 2):347-58.
2009: Okamoto H
TT viruses in animals.
Current topics in microbiology and immunology 2009;331():35-52.
2009: Okamoto H
History of discoveries and pathogenicity of TT viruses.
Current topics in microbiology and immunology 2009;331():1-20.
2008: Lorenzo Felipe R; Tanaka Toshinori; Takahashi Hideyuki; Ichiyama Koji; Hoshino Yu; Yamada Kentaro; Inoue Jun; Takahashi Masaharu; Okamoto Hiroaki
Mutational events during the primary propagation and consecutive passages of hepatitis E virus strain JE03-1760F in cell culture.
Virus research 2008;137(1):86-96.
2008: Ninomiya Masashi; Takahashi Masaharu; Nishizawa Tsutomu; Shimosegawa Tooru; Okamoto Hiroaki
Development of PCR assays with nested primers specific for differential detection of three human anelloviruses and early acquisition of dual or triple infection during infancy.
Journal of clinical microbiology 2008;46(2):507-14.
2008: Takahashi Masaharu; Yamada Kentaro; Hoshino Yu; Takahashi Hideyuki; Ichiyama Koji; Tanaka Toshinori; Okamoto Hiroaki
Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces.
Archives of virology 2008;153(9):1703-13.
2008: Takahashi Masaharu; Hoshino Yu; Tanaka Toshinori; Takahashi Hideyuki; Nishizawa Tsutomu; Okamoto Hiroaki
Production of monoclonal antibodies against hepatitis E virus capsid protein and evaluation of their neutralizing activity in a cell culture system.
Archives of virology 2008;153(4):657-66.
2007: Shrestha Santosh Man; Shrestha Shobhana; Shrestha Ananta; Tsuda Fumio; Endo Kazunori; Takahashi Masaharu; Okamoto Hiroaki
High prevalence of hepatitis B virus infection and inferior vena cava obstruction among patients with liver cirrhosis or hepatocellular carcinoma in Nepal.
Journal of gastroenterology and hepatology 2007;22(11):1921-8.
2007: Takahashi Masaharu; Tanaka Toshinori; Azuma Masahiro; Kusano Eiji; Aikawa Tatsuya; Shibayama Takao; Yazaki Yasuyuki; Mizuo Hitoshi; Inoue Jun; Okamoto Hiroaki
Prolonged fecal shedding of hepatitis E virus (HEV) during sporadic acute hepatitis E: evaluation of infectivity of HEV in fecal specimens in a cell culture system.
Journal of clinical microbiology 2007;45(11):3671-9.
2007: Lorenzo Felipe R; Tsatsralt-Od Bira; Ganbat Sanjaa; Takahashi Masaharu; Okamoto Hiroaki
Analysis of the full-length genome of hepatitis E virus isolates obtained from farm pigs in Mongolia.
Journal of medical virology 2007;79(8):1128-37.
2007: Tsatsralt-Od Bira; Takahashi Masaharu; Endo Kazunori; Agiimaa Dondog; Buyankhuu Osorjin; Ninomiya Masashi; Lorenzo Felipe R; Okamoto Hiroaki
Prevalence of hepatitis B, C, and delta virus infections among children in Mongolia: progress in childhood immunization.
Journal of medical virology 2007;79(8):1064-74.
2007: Okamoto Hiroaki
Genetic variability and evolution of hepatitis E virus.
Virus research 2007;127(2):216-28.
2007: Ninomiya Masashi; Nishizawa Tsutomu; Takahashi Masaharu; Lorenzo Felipe R; Shimosegawa Tooru; Okamoto Hiroaki
Identification and genomic characterization of a novel human torque teno virus of 3.2 kb.
The Journal of general virology 2007;88(Pt 7):1939-44.
2007: Gotanda Yuhko; Iwata Akiko; Ohnuma Hitoshi; Yoshikawa Akira; Mizoguchi Hideaki; Endo Kazunori; Takahashi Masaharu; Okamoto Hiroaki
Ongoing subclinical infection of hepatitis E virus among blood donors with an elevated alanine aminotransferase level in Japan.
Journal of medical virology 2007;79(6):734-42.
2007: Endo Kazunori; Takahashi Masaharu; Masuko Kazuo; Inoue Kazuaki; Akahane Yoshihiro; Okamoto Hiroaki
Full-length sequences of subgenotype IIIA and IIIB hepatitis A virus isolates: characterization of genotype III HAV genomes.
Virus research 2007;126(1-2):116-27.
2007: Sainokami Shigehiko; Abe Koichi; Sato Akihiro; Endo Ryujin; Takikawa Yasuhiro; Suzuki Kazuyuki; Okamoto Hiroaki
Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection.
Journal of gastroenterology 2007;42(3):241-9.
2007: Tanaka Toshinori; Takahashi Masaharu; Kusano Eiji; Okamoto Hiroaki
Development and evaluation of an efficient cell-culture system for Hepatitis E virus.
The Journal of general virology 2007;88(Pt 3):903-11.
2007: Kumagai Ichiro; Abe Koichi; Oikawa Takayoshi; Sato Akihiro; Sato Shinichiro; Endo Ryujin; Takikawa Yasuhiro; Suzuki Kazuyuki; Masuda Tomoyuki; Sainokami Shigehiko; Endo Kazunori; Takahashi Masaharu; Okamoto Hiroaki
A male patient with severe acute hepatitis who was domestically infected with a genotype H hepatitis B virus in Iwate, Japan.
Journal of gastroenterology 2007;42(2):168-75.
2007: Takikawa Yasuhiro; Yasumi Yuki; Sato Akihiro; Endo Ryujin; Suzuki Kazuyuki; Mori Yasuki; Akasaka Hidetoshi; Miura Yasuhiro; Sawai Takashi; Okamoto Hiroaki
A case of acute hepatitis E associated with multidrug hypersensitivity and cytomegalovirus reactivation.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37(2):158-65.
2007: Tsatsralt-Od Bira; Takahashi Masaharu; Endo Kazunori; Agiimaa Dondog; Buyankhuu Osorjin; Okamoto Hiroaki
Comparison of hepatitis A and E virus infections among healthy children in Mongolia: evidence for infection with a subgenotype IA HAV in children.
Journal of medical virology 2007;79(1):18-25.
2007: Endo Kazunori; Inoue Jun; Takahashi Masaharu; Mitsui Takehiro; Masuko Kazuo; Akahane Yoshihiro; Okamoto Hiroaki
Analysis of the full-length genome of a subgenotype IIIB hepatitis A virus isolate: primers for broadly reactive PCR and genotypic analysis.
Journal of medical virology 2007;79(1):8-17.
2007: Ninomiya M; Takahashi M; Shimosegawa T; Okamoto H
Analysis of the entire genomes of fifteen torque teno midi virus variants classifiable into a third group of genus Anellovirus.
Archives of virology 2007;152(11):1961-75.
2006: Inoue Jun; Takahashi Masaharu; Yazaki Yasuyuki; Tsuda Fumio; Okamoto Hiroaki
Development and validation of an improved RT-PCR assay with nested universal primers for detection of hepatitis E virus strains with significant sequence divergence.
Journal of virological methods 2006;137(2):325-33.
2006: Inoue Jun; Takahashi Masaharu; Ito Keiichi; Shimosegawa Tooru; Okamoto Hiroaki
Analysis of human and swine hepatitis E virus (HEV) isolates of genotype 3 in Japan that are only 81-83 % similar to reported HEV isolates of the same genotype over the entire genome.
The Journal of general virology 2006;87(Pt 8):2363-9.
2006: Mitsui Takehiro; Tsukamoto Yukie; Hirose Akinori; Suzuki Shigeru; Yamazaki Chikao; Masuko Kazuo; Tsuda Fumio; Endo Kazunori; Takahashi Masaharu; Okamoto Hiroaki
Distinct changing profiles of hepatitis A and E virus infection among patients with acute hepatitis, patients on maintenance hemodialysis and healthy individuals in Japan.
Journal of medical virology 2006;78(8):1015-24.
2006: Tsatsralt-Od Bira; Takahashi Masaharu; Endo Kazunori; Buyankhuu Osorjin; Baatarkhuu Oidov; Nishizawa Tsutomu; Okamoto Hiroaki
Infection with hepatitis A, B, C, and delta viruses among patients with acute hepatitis in Mongolia.
Journal of medical virology 2006;78(5):542-50.
2006: Inoue Jun; Nishizawa Tsutomu; Takahashi Masaharu; Aikawa Tatsuya; Mizuo Hitoshi; Suzuki Kazuyuki; Shimosegawa Tooru; Okamoto Hiroaki
Analysis of the full-length genome of genotype 4 hepatitis E virus isolates from patients with fulminant or acute self-limited hepatitis E.
Journal of medical virology 2006;78(4):476-84.
2005: Nishizawa Tsutomu; Takahashi Masaharu; Endo Kazunori; Fujiwara Shinji; Sakuma Nobuo; Kawazuma Fumiaki; Sakamoto Hirotsugu; Sato Yukihiro; Bando Masashi; Okamoto Hiroaki
Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan.
The Journal of general virology 2005;86(Pt 12):3321-6.
2005: Tsatsralt-Od Bira; Takahashi Masaharu; Nishizawa Tsutomu; Endo Kazunori; Inoue Jun; Okamoto Hiroaki
High prevalence of dual or triple infection of hepatitis B, C, and delta viruses among patients with chronic liver disease in Mongolia.
Journal of medical virology 2005;77(4):491-9.
2005: Tsatsralt-Od B; Takahashi M; Nishizawa T; Inoue J; Ulaankhuu D; Okamoto H
High prevalence of hepatitis B, C and delta virus infections among blood donors in Mongolia.
Archives of virology 2005;150(12):2513-28.
2005: Mitsui Takehiro; Tsukamoto Yukie; Suzuki Shigeru; Yamazaki Chikao; Masuko Kazuo; Tsuda Fumio; Takahashi Masaharu; Tsatsralt-Od Bira; Nishizawa Tsutomu; Okamoto Hiroaki
Serological and molecular studies on subclinical hepatitis E virus infection using periodic serum samples obtained from healthy individuals.
Journal of medical virology 2005;76(4):526-33.
2005: Mizuo Hitoshi; Yazaki Yasuyuki; Sugawara Kenji; Tsuda Fumio; Takahashi Masaharu; Nishizawa Tsutomu; Okamoto Hiroaki
Possible risk factors for the transmission of hepatitis E virus and for the severe form of hepatitis E acquired locally in Hokkaido, Japan.
Journal of medical virology 2005;76(3):341-9.
2005: Inoue Jun; Takahashi Masaharu; Nishizawa Tsutomu; Narantuya Luvsanbasaryn; Sakuma Mitsuru; Kagawa Yasuo; Shimosegawa Tooru; Okamoto Hiroaki
High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia.
Journal of medical virology 2005;76(3):333-40.
2005: Takahashi Masaharu; Nishizawa Tsutomu; Tanaka Toshinori; Tsatsralt-Od Bira; Inoue Jun; Okamoto Hiroaki
Correlation between positivity for immunoglobulin A antibodies and viraemia of swine hepatitis E virus observed among farm pigs in Japan.
The Journal of general virology 2005;86(Pt 6):1807-13.
2005: Tokita Hajime; Fukui Hideo; Tanaka Akihisa; Kamitsukasa Hiroshi; Yagura Michiyasu; Harada Hideharu; Okamoto Hiroaki
Risk factors for the development of hepatocellular carcinoma among patients with chronic hepatitis C who achieved a sustained virological response to interferon therapy.
Journal of gastroenterology and hepatology 2005;20(5):752-8.
2005: Takahashi Masaharu; Kusakai Shigeyuki; Mizuo Hitoshi; Suzuki Kazuyuki; Fujimura Kuniko; Masuko Kazuo; Sugai Yoshiki; Aikawa Tatsuya; Nishizawa Tsutomu; Okamoto Hiroaki
Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) Is highly specific for diagnosis of acute HEV infection.
Journal of clinical microbiology 2005;43(1):49-56.
2004: Mitsui Takehiro; Tsukamoto Yukie; Yamazaki Chikao; Masuko Kazuo; Tsuda Fumio; Takahashi Masaharu; Nishizawa Tsutomu; Okamoto Hiroaki
Prevalence of hepatitis E virus infection among hemodialysis patients in Japan: evidence for infection with a genotype 3 HEV by blood transfusion.
Journal of medical virology 2004;74(4):563-72.
2004: Okamoto Hiroaki
[Molecular biology of TTV]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 8():557-65.
2004: Okamoto Hiroaki
[Hepatitis E as a zoonosis]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 8():524-31.
2004: Okamoto Hiroaki
[Anti-HBs escape mutants--implication of neutralization escape and diagnostic escape]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 8():98-105.
2004: Tokita Hajime; Okamoto Hiroaki
[Genotyping of hepatitis C virus based on the full genome sequence]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 7(Pt 1):70-5.
2004: Sainokami Shigehiko; Abe Koichi; Kumagai Ichiro; Miyasaka Akio; Endo Ryujin; Takikawa Yasuhiro; Suzuki Kazuyuki; Mizuo Hitoshi; Sugai Yoshiki; Akahane Yoshihiro; Koizumi Yoichi; Yajima Yoshiaki; Okamoto Hiroaki
Epidemiological and clinical study of sporadic acute hepatitis E caused by indigenous strains of hepatitis E virus in Japan compared with acute hepatitis A.
Journal of gastroenterology 2004;39(7):640-8.
2004: Takahashi Masaharu; Nishizawa Tsutomu; Gotanda Yuhko; Tsuda Fumio; Komatsu Fumio; Kawabata Terue; Hasegawa Kyoko; Altankhuu Murdorjyn; Chimedregzen Ulziiburen; Narantuya Luvsanbasaryn; Hoshino Hiromi; Hino Kunihiko; Kagawa Yasuo; Okamoto Hiroaki
High prevalence of antibodies to hepatitis A and E viruses and viremia of hepatitis B, C, and D viruses among apparently healthy populations in Mongolia.
Clinical and diagnostic laboratory immunology 2004;11(2):392-8.
2004: Shrestha Santosh Man; Shrestha Shobhana; Tsuda Fumio; Nishizawa Tsutomu; Takahashi Masaharu; Gotanda Yuhko; Okamoto Hiroaki
Genetic changes in hepatitis E virus of subtype 1a in patients with sporadic acute hepatitis E in Kathmandu, Nepal, from 1997 to 2002.
The Journal of general virology 2004;85(Pt 1):97-104.
2003: Okamoto Hiroaki; Takahashi Masaharu; Nishizawa Tsutomu
Features of hepatitis E virus infection in Japan.
Internal medicine (Tokyo, Japan) 2003;42(11):1065-71.
2003: Yazaki Yasuyuki; Mizuo Hitoshi; Takahashi Masaharu; Nishizawa Tsutomu; Sasaki Nobuhiko; Gotanda Yuhko; Okamoto Hiroaki
Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food.
The Journal of general virology 2003;84(Pt 9):2351-7.
2003: Nishizawa Tsutomu; Takahashi Masaharu; Mizuo Hitoshi; Miyajima Haruko; Gotanda Yuhko; Okamoto Hiroaki
Characterization of Japanese swine and human hepatitis E virus isolates of genotype IV with 99 % identity over the entire genome.
The Journal of general virology 2003;84(Pt 5):1245-51.
2003: Takahashi Masaharu; Nishizawa Tsutomu; Miyajima Haruko; Gotanda Yuhko; Iita Teruhiko; Tsuda Fumio; Okamoto Hiroaki
Swine hepatitis E virus strains in Japan form four phylogenetic clusters comparable with those of Japanese isolates of human hepatitis E virus.
The Journal of general virology 2003;84(Pt 4):851-62.
2003: Shrestha Santosh Man; Shrestha Shobhana; Tsuda Fumio; Nishizawa Tsutomu; Gotanda Yuhko; Takeda Naokazu; Okamoto Hiroaki
Molecular investigation of hepatitis E virus infection in patients with acute hepatitis in Kathmandu, Nepal.
Journal of medical virology 2003;69(2):207-14.
2003: Tokita Hajime; Harada Hideharu; Gotanda Yuhko; Takahashi Masaharu; Nishizawa Tsutomu; Okamoto Hiroaki
Molecular and serological characterization of sporadic acute hepatitis E in a Japanese patient infected with a genotype III hepatitis E virus in 1993.
The Journal of general virology 2003;84(Pt 2):421-7.
2002: Mizuo Hitoshi; Suzuki Kazuyuki; Takikawa Yasuhiro; Sugai Yoshiki; Tokita Hajime; Akahane Yoshihiro; Itoh Keiichi; Gotanda Yuhko; Takahashi Masaharu; Nishizawa Tsutomu; Okamoto Hiroaki
Polyphyletic strains of hepatitis E virus are responsible for sporadic cases of acute hepatitis in Japan.
Journal of clinical microbiology 2002;40(9):3209-18.
2002: Takahashi Masaharu; Nishizawa Tsutomu; Yoshikawa Akira; Sato Shin; Isoda Norio; Ido Kenichi; Sugano Kentaro; Okamoto Hiroaki
Identification of two distinct genotypes of hepatitis E virus in a Japanese patient with acute hepatitis who had not travelled abroad.
The Journal of general virology 2002;83(Pt 8):1931-40.
2002: Tokita Hajime; Murai Seiyou; Kamitsukasa Hiroshi; Yagura Michiyasu; Harada Hideharu; Takahashi Masaharu; Okamoto Hiroaki
High TT virus load as an independent factor associated with the occurrence of hepatocellular carcinoma among patients with hepatitis C virus-related chronic liver disease.
Journal of medical virology 2002;67(4):501-9.
2002: Okamoto Hiroaki; Takahashi Masaharu; Nishizawa Tsutomu; Tawara Akio; Fukai Katsuhiko; Muramatsu Umetaro; Naito Yoshihisa; Yoshikawa Akira
Genomic characterization of TT viruses (TTVs) in pigs, cats and dogs and their relatedness with species-specific TTVs in primates and tupaias.
The Journal of general virology 2002;83(Pt 6):1291-7.
2002: Shrestha S M; Takeda N; Tsuda F; Okamoto H; Shrestha S; Shrestha V M
High prevalence of hepatitis B virus infection amongst Tibetans in Nepal.
Tropical gastroenterology : official journal of the Digestive Diseases Foundation 2002;23(2):63-5.
2002: Takahashi Masaharu; Asabe Shinichi; Gotanda Yuhko; Kishimoto Junichi; Tsuda Fumio; Okamoto Hiroaki
TT virus is distributed in various leukocyte subpopulations at distinct levels, with the highest viral load in granulocytes.
Biochemical and biophysical research communications 2002;290(1):242-8.
2002: Peng Y H; Nishizawa T; Takahashi M; Ishikawa T; Yoshikawa A; Okamoto H
Analysis of the entire genomes of thirteen TT virus variants classifiable into the fourth and fifth genetic groups, isolated from viremic infants.
Archives of virology 2002;147(1):21-41.
2001: Okamoto H; Takahashi M; Nishizawa T; Fukai K; Muramatsu U; Yoshikawa A
Analysis of the complete genome of indigenous swine hepatitis E virus isolated in Japan.
Biochemical and biophysical research communications 2001;289(5):929-36.
2001: Okamoto H; Nishizawa T; Takahashi M; Asabe S; Tsuda F; Yoshikawa A
Heterogeneous distribution of TT virus of distinct genotypes in multiple tissues from infected humans.
Virology 2001;288(2):358-68.
2001: Okamoto H; Nishizawa T; Takahashi M; Tawara A; Peng Y; Kishimoto J; Wang Y
Genomic and evolutionary characterization of TT virus (TTV) in tupaias and comparison with species-specific TTVs in humans and non-human primates.
The Journal of general virology 2001;82(Pt 9):2041-50.
2001: Okamoto H; Mayumi M
TT virus: virological and genomic characteristics and disease associations.
Journal of gastroenterology 2001;36(8):519-29.
2001: Asabe S; Nishizawa T; Iwanari H; Okamoto H
Phosphorylation of serine-rich protein encoded by open reading frame 3 of the TT virus genome.
Biochemical and biophysical research communications 2001;286(2):298-304.
2000: Okamoto H; Mayumi M
[Molecular virology of TT virus (TTV)]
Uirusu. Journal of virology 2000;50(2):259-71.
2000: Okamoto H; Nishizawa T; Tawara A; Takahashi M; Kishimoto J; Sai T; Sugai Y
TT virus mRNAs detected in the bone marrow cells from an infected individual.
Biochemical and biophysical research communications 2000;279(2):700-7.
2000: Okamoto H; Asamitsu K; Nishimura H; Kamatani N; Okamoto T
Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.
Biochemical and biophysical research communications 2000;279(2):494-9.
2000: Tawara A; Akahane Y; Takahashi M; Nishizawa T; Ishikawa T; Okamoto H
Transmission of human TT virus of genotype 1a to chimpanzees with fecal supernatant or serum from patients with acute TTV infection.
Biochemical and biophysical research communications 2000;278(2):470-6.
2000: Okamoto H; Nishizawa T; Tawara A; Peng Y; Takahashi M; Kishimoto J; Tanaka T; Miyakawa Y; Mayumi M
Species-specific TT viruses in humans and nonhuman primates and their phylogenetic relatedness.
Virology 2000;277(2):368-78.
2000: Okamoto H; Takahashi M; Kato N; Fukuda M; Tawara A; Fukuda S; Tanaka T; Miyakawa Y; Mayumi M
Sequestration of TT virus of restricted genotypes in peripheral blood mononuclear cells.
Journal of virology 2000;74(21):10236-9.
2000: Okamoto H; Cujec T P; Okamoto M; Peterlin B M; Baba M; Okamoto T
Inhibition of the RNA-dependent transactivation and replication of human immunodeficiency virus type 1 by a fluoroquinoline derivative K-37.
Virology 2000;272(2):402-8.
2000: Usuda S; Okamoto H; Tanaka T; Kidd-Ljunggren K; Holland P V; Miyakawa Y; Mayumi M
Differentiation of hepatitis B virus genotypes D and E by ELISA using monoclonal antibodies to epitopes on the preS2-region product.
Journal of virological methods 2000;87(1-2):81-9.
2000: Okamoto H; Ukita M; Nishizawa T; Kishimoto J; Hoshi Y; Mizuo H; Tanaka T; Miyakawa Y; Mayumi M
Circular double-stranded forms of TT virus DNA in the liver.
Journal of virology 2000;74(11):5161-7.
2000: Okamoto H; Cujec T P; Peterlin B M; Okamoto T
HIV-1 replication is inhibited by a pseudo-substrate peptide that blocks Tat transactivation.
Virology 2000;270(2):337-44.
2000: Okamoto H; Takahashi M; Nishizawa T; Tawara A; Sugai Y; Sai T; Tanaka T; Tsuda F
Replicative forms of TT virus DNA in bone marrow cells.
Biochemical and biophysical research communications 2000;270(2):657-62.
2000: Okamoto H; Fukuda M; Tawara A; Nishizawa T; Itoh Y; Hayasaka I; Tsuda F; Tanaka T; Miyakawa Y; Mayumi M
Species-specific TT viruses and cross-species infection in nonhuman primates.
Journal of virology 2000;74(3):1132-9.
2000: Ukita M; Okamoto H; Nishizawa T; Tawara A; Takahashi M; Iizuka H; Miyakawa Y; Mayumi M
The entire nucleotide sequences of two distinct TT virus (TTV) isolates (TJN01 and TJN02) remotely related to the original TTV isolates.
Archives of virology 2000;145(8):1543-59.
1999: Nishizawa T; Okamoto H; Tsuda F; Aikawa T; Sugai Y; Konishi K; Akahane Y; Ukita M; Tanaka T; Miyakawa Y; Mayumi M
Quasispecies of TT virus (TTV) with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection.
Journal of virology 1999;73(11):9604-8.
1999: Itoh K; Takahashi M; Ukita M; Nishizawa T; Okamoto H
Influence of primers on the detection of TT virus DNA by polymerase chain reaction.
The Journal of infectious diseases 1999;180(5):1750-1.
1999: Akahane Y; Sakamoto M; Miyazaki Y; Okada S; Inoue T; Ukita M; Okamoto H; Miyakawa Y; Mayumi M
Effect of interferon on a nonenveloped DNA virus (TT virus) associated with acute and chronic hepatitis of unknown etiology.
Journal of medical virology 1999;58(3):196-200.
1999: Okamoto H; Nishizawa T; Ukita M; Takahashi M; Fukuda M; Iizuka H; Miyakawa Y; Mayumi M
The entire nucleotide sequence of a TT virus isolate from the United States (TUS01): comparison with reported isolates and phylogenetic analysis.
Virology 1999;259(2):437-48.
1999: Okamoto H; Takahashi M; Nishizawa T; Ukita M; Fukuda M; Tsuda F; Miyakawa Y; Mayumi M
Marked genomic heterogeneity and frequent mixed infection of TT virus demonstrated by PCR with primers from coding and noncoding regions.
Virology 1999;259(2):428-36.
1999: Usuda S; Okamoto H; Iwanari H; Baba K; Tsuda F; Miyakawa Y; Mayumi M
Serological detection of hepatitis B virus genotypes by ELISA with monoclonal antibodies to type-specific epitopes in the preS2-region product.
Journal of virological methods 1999;80(1):97-112.
1999: Okamoto H
[Molecular virology of TT virus]
Nippon rinsho. Japanese journal of clinical medicine 1999;57(6):1239-49.
1999: Itoh K; Hirakawa K; Okamoto H; Ukita M; Tanaka H; Sawada N; Tsuda F; Miyakawa Y; Mayumi M
Infection by an unenveloped DNA virus associated with non-A to -G hepatitis in Japanese blood donors with or without elevated ALT levels.
Transfusion 1999;39(5):522-6.
1999: Ukita M; Okamoto H; Kato N; Miyakawa Y; Mayumi M
Excretion into bile of a novel unenveloped DNA virus (TT virus) associated with acute and chronic non-A-G hepatitis.
The Journal of infectious diseases 1999;179(5):1245-8.
1999: Okamoto H; Kato N; Iizuka H; Tsuda F; Miyakawa Y; Mayumi M
Distinct genotypes of a nonenveloped DNA virus associated with posttransfusion non-A to G hepatitis (TT virus) in plasma and peripheral blood mononuclear cells.
Journal of medical virology 1999;57(3):252-8.
1999: Tsuda F; Okamoto H; Ukita M; Tanaka T; Akahane Y; Konishi K; Yoshizawa H; Miyakawa Y; Mayumi M
Determination of antibodies to TT virus (TTV) and application to blood donors and patients with post-transfusion non-A to G hepatitis in Japan.
Journal of virological methods 1999;77(2):199-206.
1999: Traber K E; Okamoto H; Kurono C; Baba M; Saliou C; Soji T; Packer L; Okamoto T
Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells.
International immunology 1999;11(2):143-50.
1999: Okamoto H; Nishizawa T; Ukita M
A novel unenveloped DNA virus (TT virus) associated with acute and chronic non-A to G hepatitis.
Intervirology 1999;42(2-3):196-204.
1998: Okamoto H; Akahane Y; Ukita M; Fukuda M; Tsuda F; Miyakawa Y; Mayumi M
Fecal excretion of a nonenveloped DNA virus (TTV) associated with posttransfusion non-A-G hepatitis.
Journal of medical virology 1998;56(2):128-32.
1998: Tokita H; Okamoto H; Iizuka H; Kishimoto J; Tsuda F; Miyakawa Y; Mayumi M
The entire nucleotide sequences of three hepatitis C virus isolates in genetic groups 7-9 and comparison with those in the other eight genetic groups.
The Journal of general virology 1998;79 ( Pt 8)():1847-57.
1998: Shrestha S M; Subedi N B; Shrestha S; Maharjan K G; Tsuda F; Okamoto H
Epidemiology of hepatitis C virus infection in Nepal.
Tropical gastroenterology : official journal of the Digestive Diseases Foundation 1998;19(3):102-4.
1998: Usuda S; Okamoto H; Tsuda F; Tanaka T; Miyakawa Y; Mayumi M
An enzyme-linked immunosorbent assay with monoclonal antibodies for the determination of phosphorylated hepatitis B core protein (p21c) in serum.
Journal of virological methods 1998;72(1):95-103.
1998: Kanai K; Kako M; Kumada T; Tsubouchi H; Aikawa T; Kojima M; Harada H; Kawasaki T; Nakashima M; Okamoto H; Mishiro S
High-dose (9 MU) long-term (60 weeks) alfa-interferon therapy for chronic hepatitis patients infected with HCV genotype 1b.
Archives of virology 1998;143(8):1545-54.
1997: Nishizawa T; Okamoto H; Konishi K; Yoshizawa H; Miyakawa Y; Mayumi M
A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology.
Biochemical and biophysical research communications 1997;241(1):92-7.
1997: Usuda S; Okamoto H; Ohnuma H; Tanaka T; Machida A; Miyakawa Y; Mayumi M
A monoclonal antibody against a hepatitis B e antigen epitope borne by six amino acids encoded by the precore region.
Journal of virological methods 1997;68(2):207-15.
1997: Inoue T; Sakamoto M; Akahane Y; Okamoto H; Miyakawa Y; Mayumi M
Response to interferon of GB virus C and hepatitis C virus in patients with chronic hepatitis.
The American journal of gastroenterology 1997;92(11):1981-5.
1997: Shrestha S M; Shrestha S; Tsuda F; Sawada N; Tanaka T; Okamoto H; Miyakawa Y; Mayumi M
Infection with GB virus C and hepatitis C virus in drug addicts, patients on maintenance hemodialysis, or with chronic liver disease in Nepal.
Journal of medical virology 1997;53(2):157-61.
1997: Cujec T P; Okamoto H; Fujinaga K; Meyer J; Chamberlin H; Morgan D O; Peterlin B M
The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II.
Genes & development 1997;11(20):2645-57.
1997: Kako M; Kanai K; Aikawa T; Iwabuchi S; Takehira Y; Kawasaki T; Tsubouchi H; Hino K; Tsuda F; Okamoto H; Miyakawa Y; Mayumi M
Response to interferon-alpha 2a in patients with e antigen-negative chronic hepatitis B.
Journal of clinical gastroenterology 1997;25(2):440-5.
1997: Nakao H; Okamoto H; Fukuda M; Tsuda F; Mitsui T; Masuko K; Iizuka H; Miyakawa Y; Mayumi M
Mutation rate of GB virus C/hepatitis G virus over the entire genome and in subgenomic regions.
Virology 1997;233(1):43-50.
1997: Okamoto H; Nakao H; Inoue T; Fukuda M; Kishimoto J; Iizuka H; Tsuda F; Miyakawa Y; Mayumi M
The entire nucleotide sequences of two GB virus C/hepatitis G virus isolates of distinct genotypes from Japan.
The Journal of general virology 1997;78 ( Pt 4)():737-45.
1997: Okamoto H
[Hepatitis G virus (HGBV-C/HGV) as a putative agent for non-A to E hepatitis]
Nippon rinsho. Japanese journal of clinical medicine 1997;55(3):515-22.
1997: Watanabe T; Ishiguro M; Kametani M; Sugai Y; Takakuwa K; Akahane Y; Masuko K; Shimizu M; Kojima M; Fujita K; Tsuda F; Okamoto H
GB virus C and hepatitis C virus infections in hemodialysis patients in eight Japanese centers.
Nephron 1997;76(2):171-5.
1996: Moriyama K; Okamoto H; Tsuda F; Mayumi M
Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus DNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections.
Virology 1996;226(2):269-80.
1996: Shrestha S M; Shrestha D M; Gafney T E; Maharjan K G; Tsuda F; Okamoto H
Hepatitis B and C infection among drug abusers in Nepal.
Tropical gastroenterology : official journal of the Digestive Diseases Foundation 1996;17(4):212-3.
1996: Kanai K; Kako M; Aikawa T; Hino K; Tsubouchi H; Takehira Y; Iwabuchi S; Kawasaki T; Tsuda F; Okamoto H; Miyakawa Y; Mayumi M
Core promoter mutations of hepatitis B virus for the response to interferon in e antigen-positive chronic hepatitis B.
The American journal of gastroenterology 1996;91(10):2150-6.
1996: Kohno H; Inoue T; Tsuda F; Okamoto H; Akahane Y
Mutations in the envelope gene of hepatitis B virus variants co-occurring with antibody to surface antigen in sera from patients with chronic hepatitis B.
The Journal of general virology 1996;77 ( Pt 8)():1825-31.
1996: Tsuda F; Hadiwandowo S; Sawada N; Fukuda M; Tanaka T; Okamoto H; Miyakawa Y; Mayumi M
Infection with GB virus C (GBV-C) in patients with chronic liver disease or on maintenance hemodialysis in Indonesia.
Journal of medical virology 1996;49(3):248-52.
1996: Okamoto H
[Molecular evolution of hepatitis C virus and its closely related virus]
Uirusu. Journal of virology 1996;46(1):13-21.
1996: Okamoto H; Kobata S; Tokita H; Inoue T; Woodfield G D; Holland P V; Al-Knawy B A; Uzunalimoglu O; Miyakawa Y; Mayumi M
A second-generation method of genotyping hepatitis C virus by the polymerase chain reaction with sense and antisense primers deduced from the core gene.
Journal of virological methods 1996;57(1):31-45.
1996: Tokita H; Okamoto H; Iizuka H; Kishimoto J; Tsuda F; Lesmana L A; Miyakawa Y; Mayumi M
Hepatitis C virus variants from Jakarta, Indonesia classifiable into novel genotypes in the second (2e and 2f), tenth (10a) and eleventh (11a) genetic groups.
The Journal of general virology 1996;77 ( Pt 2 )():293-301.
1996: Akahane Y; Miyazaki Y; Naitoh S; Takeda K; Tsuda F; Okamoto H; Itoh K; Miyakawa Y; Mayumi M
Cold activation of complement for monitoring the response to interferon in patients with chronic hepatitis C.
The American journal of gastroenterology 1996;91(2):319-27.
1996: Nakao H; Okamoto H; Tokita H; Inoue T; Iizuka H; Pozzato G; Mishiro S
Full-length genomic sequence of a hepatitis C virus genotype 2c isolate (BEBE1) and the 2c-specific PCR primers.
Archives of virology 1996;141(3-4):701-4.
1995: Okamoto H
[Anti-HBs escape mutants--implication of neutralization escape and diagnostic escape]
Nippon rinsho. Japanese journal of clinical medicine 1995;53 Suppl(Pt 2):212-22.
1995: Okamoto H
[Classification of hepatitis C virus genotypes and its application to molecular epidemiology]
Nippon rinsho. Japanese journal of clinical medicine 1995;53 Suppl(Pt 1):71-9.
1995: Okamoto H
[PCR-based genotyping with genotype-specific primers derived from the C gene of HCV genome]
Nippon rinsho. Japanese journal of clinical medicine 1995;53 Suppl(Pt 1):312-20.
1995: Tokita H; Okamoto H; Luengrojanakul P; Vareesangthip K; Chainuvati T; Iizuka H; Tsuda F; Miyakawa Y; Mayumi M
Hepatitis C virus variants from Thailand classifiable into five novel genotypes in the sixth (6b), seventh (7c, 7d) and ninth (9b, 9c) major genetic groups.
The Journal of general virology 1995;76 ( Pt 9)():2329-35.
1995: Aikawa T; Kanai K; Kako M; Kawasaki T; Hino K; Iwabuchi S; Tsubouchi H; Takehira Y; Tsuda F; Okamoto H
Interferon-alpha 2a for chronic hepatitis B with e antigen or antibody:comparable antiviral effects on wild-type virus and precore mutant.
Journal of viral hepatitis 1995;2(5):243-50.
1994: Okamoto H; Tsuda F; Akahane Y; Sugai Y; Yoshiba M; Moriyama K; Tanaka T; Miyakawa Y; Mayumi M
Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen.
Journal of virology 1994;68(12):8102-10.
1994: Tokita H; Okamoto H; Tsuda F; Song P; Nakata S; Chosa T; Iizuka H; Mishiro S; Miyakawa Y; Mayumi M
Hepatitis C virus variants from Vietnam are classifiable into the seventh, eighth, and ninth major genetic groups.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11022-6.
1994: Okamoto H; Mishiro S; Tokita H; Tsuda F; Miyakawa Y; Mayumi M
Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a.
Hepatology (Baltimore, Md.) 1994;20(5):1131-6.
1994: Luengrojanakul P; Vareesangthip K; Chainuvati T; Murata K; Tsuda F; Tokita H; Okamoto H; Miyakawa Y; Mayumi M
Hepatitis C virus infection in patients with chronic liver disease or chronic renal failure and blood donors in Thailand.
Journal of medical virology 1994;44(3):287-92.
1994: Saitoh H; Naitoh S; Okamoto H; Akahane Y
Prompt decrease of circulating hepatitis C virus in patients with chronic hepatitis C after treatment with interferon.
Journal of interferon research 1994;14(5):239-44.
1994: Suzuki H; Iino S; Shiraki K; Akahane Y; Okamoto H; Domoto K; Mishiro S
Safety and efficacy of a recombinant yeast-derived pre-S2 + S-containing hepatitis B vaccine (TGP-943): phase 1, 2 and 3 clinical testing.
Vaccine 1994;12(12):1090-6.
1994: Song P; Duc D D; Hien B; Nakata S; Chosa T; Watanabe J; Tsuda F; Murata K; Okamoto H
Markers of hepatitis C and B virus infections among blood donors in Ho Chi Minh City and Hanoi, Vietnam.
Clinical and diagnostic laboratory immunology 1994;1(4):413-8.
1994: Sakamoto M; Akahane Y; Tsuda F; Tanaka T; Woodfield D G; Okamoto H
Entire nucleotide sequence and characterization of a hepatitis C virus of genotype V/3a.
The Journal of general virology 1994;75 ( Pt 7)():1761-8.
1994: Nakata S; Song P; Duc D D; Nguyen X Q; Murata K; Tsuda F; Okamoto H
Hepatitis C and B virus infections in populations at low or high risk in Ho Chi Minh and Hanoi, Vietnam.
Journal of gastroenterology and hepatology 1994;9(4):416-9.
1994: Okamoto H
[PCR-based HCV genotyping with type-specific primers derived from core gene and IFN responsiveness]
Nippon rinsho. Japanese journal of clinical medicine 1994;52(7):1699-706.
1994: Tokita H; Shrestha S M; Okamoto H; Sakamoto M; Horikita M; Iizuka H; Shrestha S; Miyakawa Y; Mayumi M
Hepatitis C virus variants from Nepal with novel genotypes and their classification into the third major group.
The Journal of general virology 1994;75 ( Pt 4)():931-6.
1994: Yamamoto K; Horikita M; Tsuda F; Itoh K; Akahane Y; Yotsumoto S; Okamoto H; Miyakawa Y; Mayumi M
Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen.
Journal of virology 1994;68(4):2671-6.
1994: Shrestha S M; Tsuda F; Okamoto H; Tokita H; Horikita M; Tanaka T; Miyakawa Y; Mayumi M
Hepatitis B virus subtypes and hepatitis C virus genotypes in patients with chronic liver disease in Nepal.
Hepatology (Baltimore, Md.) 1994;19(4):805-9.
1994: Okamoto H; Kojima M; Sakamoto M; Iizuka H; Hadiwandowo S; Suwignyo S; Miyakawa Y; Mayumi M
The entire nucleotide sequence and classification of a hepatitis C virus isolate of a novel genotype from an Indonesian patient with chronic liver disease.
The Journal of general virology 1994;75 ( Pt 3)():629-35.
1993: Okamoto H
[Genetic mutation of hepatitis C virus and host's immune response]
Uirusu. Journal of virology 1993;43(2):305-13.
1993: Okamoto H; Tokita H; Sakamoto M; Horikita M; Kojima M; Iizuka H; Mishiro S
Characterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection.
The Journal of general virology 1993;74 ( Pt 11)():2385-90.
1993: Okamoto H; Wang Y; Tanaka T; Machida A; Miyakawa Y; Mayumi M
Trans-complementation among naturally occurring deletion mutants of hepatitis B virus and integrated viral DNA for the production of viral particles with mutant genomes in hepatoma cell lines.
The Journal of general virology 1993;74 ( Pt 3)():407-14.
1993: Ohnuma H; Machida A; Okamoto H; Tsuda F; Sakamoto M; Tanaka T; Miyakawa Y; Mayumi M
Allelic subtypic determinants of hepatitis B surface antigen (i and t) that are distinct from d/y or w/r.
Journal of virology 1993;67(2):927-32.
1992: Machida A; Ohnuma H; Tsuda F; Munekata E; Tanaka T; Akahane Y; Okamoto H; Mishiro S
Two distinct subtypes of hepatitis C virus defined by antibodies directed to the putative core protein.
Hepatology (Baltimore, Md.) 1992;16(4):886-91.
1992: Okamoto H; Kojima M; Okada S; Yoshizawa H; Iizuka H; Tanaka T; Muchmore E E; Peterson D A; Ito Y; Mishiro S
Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability.
Virology 1992;190(2):894-9.
1992: Okamoto H; Yano K; Nozaki Y; Matsui A; Miyazaki H; Yamamoto K; Tsuda F; Machida A; Mishiro S
Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine.
Pediatric research 1992;32(3):264-8.
1992: Okada S; Akahane Y; Suzuki H; Okamoto H; Mishiro S
The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients.
Hepatology (Baltimore, Md.) 1992;16(3):619-24.
1992: Yotsumoto S; Kojima M; Shoji I; Yamamoto K; Okamoto H; Mishiro S
Fulminant hepatitis related to transmission of hepatitis B variants with precore mutations between spouses.
Hepatology (Baltimore, Md.) 1992;16(1):31-5.
1992: Okamoto H; Kurai K; Okada S; Yamamoto K; Lizuka H; Tanaka T; Fukuda S; Tsuda F; Mishiro S
Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes.
Virology 1992;188(1):331-41.
1992: Okamoto H; Sugiyama Y; Okada S; Kurai K; Akahane Y; Sugai Y; Tanaka T; Sato K; Tsuda F; Miyakawa Y
Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources.
The Journal of general virology 1992;73 ( Pt 3)():673-9.
1992: Okamoto H; Tsuda F; Machida A; Munekata E; Akahane Y; Sugai Y; Mashiko K; Mitsui T; Tanaka T; Miyakawa Y
Antibodies against synthetic oligopeptides deduced from the putative core gene for the diagnosis of hepatitis virus infection.
Hepatology (Baltimore, Md.) 1992;15(2):180-6.
1991: Okamoto H; Okada S; Sugiyama Y; Kurai K; Iizuka H; Machida A; Miyakawa Y; Mayumi M
Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions.
The Journal of general virology 1991;72 ( Pt 11)():2697-704.
1991: Sastrosoewignjo R I; Sandjaja B; Okamoto H
Molecular epidemiology of hepatitis B virus in Indonesia.
Journal of gastroenterology and hepatology 1991;6(5):491-8.
1990: Takeda K; Akahane Y; Suzuki H; Okamoto H; Tsuda F; Miyakawa Y; Mayumi M
Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with interferon therapy.
Hepatology (Baltimore, Md.) 1990;12(6):1284-9.
1990: Akahane Y; Yamanaka T; Suzuki H; Sugai Y; Tsuda F; Yotsumoto S; Omi S; Okamoto H; Miyakawa Y; Mayumi M
Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in the serum. Disturbed synthesis and secretion of e antigen from hepatocytes due to a point mutation in the precore region.
Gastroenterology 1990;99(4):1113-9.
1990: Luengrojanakul P; Ohnuma H; Tachibana K; Usuda S; Okamoto H; Tanaka T; Tsuda F; Machida A; Mayumi M
Common and subtypic determinants of hepatitis B surface antigen particles: susceptibility to reduction and/or alkylation evaluated with monoclonal antibodies.
The Japanese journal of experimental medicine 1990;60(5):253-61.
1990: Okamoto H; Munekata E; Tsuda F; Takahashi K; Yotsumoto S; Tanaka T; Tachibana K; Akahane Y; Sugai Y; Miyakawa Y
Enzyme-linked immunosorbent assay for antibodies against the capsid protein of hepatitis C virus with a synthetic oligopeptide.
The Japanese journal of experimental medicine 1990;60(4):223-33.
1990: Okamoto H; Okada S; Sugiyama Y; Tanaka T; Sugai Y; Akahane Y; Machida A; Mishiro S; Yoshizawa H; Miyakawa Y
Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5'-noncoding region.
The Japanese journal of experimental medicine 1990;60(4):215-22.
1990: Okamoto H; Okada S; Sugiyama Y; Yotsumoto S; Tanaka T; Yoshizawa H; Tsuda F; Miyakawa Y; Mayumi M
The 5'-terminal sequence of the hepatitis C virus genome.
The Japanese journal of experimental medicine 1990;60(3):167-77.
1990: Yotsumoto S; Okamoto H; Tsuda F; Miyakawa Y; Mayumi M
Subtyping hepatitis B virus DNA in free or integrated forms by amplification of the S-gene sequences by the polymerase chain reaction and single-track sequencing for adenine.
Journal of virological methods 1990;28(2):107-16.
1990: Okamoto H
[Structure of hepatitis B virus and its related serological markers]
Rinsho byori. The Japanese journal of clinical pathology 1990;38(5):568-72.
1990: Yamanaka T; Akahane Y; Suzuki H; Okamoto H; Tsuda F; Miyakawa Y; Mayumi M
Hepatitis B surface antigen particles with all four subtypic determinants: point mutations of hepatitis B virus DNA inducing phenotypic changes or double infection with viruses of different subtypes.
Molecular immunology 1990;27(5):443-9.
1990: Okamoto H; Omi S; Wang Y; Imai M; Mayumi M
Trans-complementation of the C gene of human and the P gene of woodchuck hepadnaviruses.
The Journal of general virology 1990;71 ( Pt 4)():959-63.
1990: Okamoto H; Yotsumoto S; Akahane Y; Yamanaka T; Miyazaki Y; Sugai Y; Tsuda F; Tanaka T; Miyakawa Y; Mayumi M
Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen.
Journal of virology 1990;64(3):1298-303.
1990: Yotsumoto S; Omi S; Okada S; Okamoto H
[Clinical significance of hepatitis delta virus marker analysis]
Nippon rinsho. Japanese journal of clinical medicine 1990;48 Suppl():304-8.
1990: Yamanaka T; Yotsumoto S; Omi S; Okamoto H
[Clinical significance of hepatitis B virus marker analysis]
Nippon rinsho. Japanese journal of clinical medicine 1990;48 Suppl():291-7.
1989: Okamoto H; Yotsumoto S; Tsuda F; Machida A; Mayumi M
Quantitative and qualitative differences in serum HBV DNA between HBeAg positive carriers and those positive for anti-HBe.
The Japanese journal of experimental medicine 1989;59(6):259-62.
1989: Okamoto H; Omi S; Wang Y; Itoh Y; Tsuda F; Tanaka T; Akahane Y; Miyakawa Y; Mayumi M
The loss of subtypic determinants in alleles, d/y or w/r, on hepatitis B surface antigen.
Molecular immunology 1989;26(2):197-205.
1988: Okamoto H; Tsuda F; Sakugawa H; Sastrosoewignjo R I; Imai M; Miyakawa Y; Mayumi M
Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes.
The Journal of general virology 1988;69 ( Pt 10)():2575-83.
1987: Imai M; Hoshi Y; Okamoto H; Matsui T; Tsurimoto T; Matsubara K; Miyakawa Y; Mayumi M
Free and integrated forms of hepatitis B virus DNA in human hepatocellular carcinoma cells (PLC/342) propagated in nude mice.
Journal of virology 1987;61(11):3555-60.
1987: Okamoto H; Imai M; Miyakawa Y; Mayumi M
Site-directed mutagenesis of hepatitis B surface antigen sequence at codon 160 from arginine to lysine for conversion of subtypic determinant from r to w.
Biochemical and biophysical research communications 1987;148(1):500-4.
1987: Okamoto H; Imai M; Kametani M; Nakamura T; Mayumi M
Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission.
The Japanese journal of experimental medicine 1987;57(4):231-6.
1987: Okamoto H; Tsuda F; Mayumi M
Defective mutants of hepatitis B virus in the circulation of symptom-free carriers.
The Japanese journal of experimental medicine 1987;57(4):217-21.
1985: Okamoto H; Imai M; Usuda S; Tanaka E; Tachibana K; Mishiro S; Machida A; Nakamura T; Miyakawa Y; Mayumi M
Hemagglutination assay of polypeptide coded by the pre-S region of hepatitis B virus DNA with monoclonal antibody: correlation of pre-S polypeptide with the receptor for polymerized human serum albumin in serums containing hepatitis B antigens.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(2):1212-6.

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