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Takayuki Okamoto

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Chemicals & Drugs

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Publications

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Hiroko Shibata; Yasuo Yoshioka; Shinji Ikemizu; Kyoko Kobayashi; Yoko Yamamoto; Yohei Mukai; Takayuki Okamoto; Madoka Taniai; Maki Kawamura; Yasuhiro Abe; Shinsaku Nakagawa; Takao Hayakawa; Satoshi Nagata; Yuriko Yamagata; Tadanori Mayumi; Haruhiko Kamada; Yasuo Tsutsumi
Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window.
Takayuki Okamoto; Yohei Mukai; Yasuo Yoshioka; Hiroko Shibata; Maki Kawamura; Yoko Yamamoto; Shinsaku Nakagawa; Haruhiko Kamada; Takao Hayakawa; Tadanori Mayumi; Yasuo Tsutsumi
Optimal construction of non-immune scFv phage display libraries from mouse bone marrow and spleen established to select specific scFvs efficiently binding to antigen.
Yasuo Yoshioka; Yasuo Tsutsumi; Yohei Mukai; Hiroko Shibata; Takayuki Okamoto; Yoshihisa Kaneda; Shin-ichi Tsunoda; Haruhiko Kamada; Keiichi Koizumi; Yoko Yamamoto; Yu Mu; Hiroshi Kodaira; Keiko Sato-Kamada; Shinsaku Nakagawa; Tadanori Mayumi
Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen.

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All Publications

2004: Hiroko Shibata; Yasuo Yoshioka; Shinji Ikemizu; Kyoko Kobayashi; Yoko Yamamoto; Yohei Mukai; Takayuki Okamoto; Madoka Taniai; Maki Kawamura; Yasuhiro Abe; Shinsaku Nakagawa; Takao Hayakawa; Satoshi Nagata; Yuriko Yamagata; Tadanori Mayumi; Haruhiko Kamada; Yasuo Tsutsumi
Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8293-300.
2004: Takayuki Okamoto; Yohei Mukai; Yasuo Yoshioka; Hiroko Shibata; Maki Kawamura; Yoko Yamamoto; Shinsaku Nakagawa; Haruhiko Kamada; Takao Hayakawa; Tadanori Mayumi; Yasuo Tsutsumi
Optimal construction of non-immune scFv phage display libraries from mouse bone marrow and spleen established to select specific scFvs efficiently binding to antigen.
Biochemical and biophysical research communications 2004;323(2):583-91.
2004: Yasuo Yoshioka; Yasuo Tsutsumi; Yohei Mukai; Hiroko Shibata; Takayuki Okamoto; Yoshihisa Kaneda; Shin-ichi Tsunoda; Haruhiko Kamada; Keiichi Koizumi; Yoko Yamamoto; Yu Mu; Hiroshi Kodaira; Keiko Sato-Kamada; Shinsaku Nakagawa; Tadanori Mayumi
Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen.
Journal of biomedical materials research. Part A 2004;70(2):219-23.
2004: Hiroshi Kodaira; Yasuo Tsutsumi; Yasuo Yoshioka; Haruhiko Kamada; Yoshihisa Kaneda; Yoko Yamamoto; Shin-ichi Tsunoda; Takayuki Okamoto; Yohei Mukai; Hiroko Shibata; Shinsaku Nakagawa; Tadanori Mayumi
The targeting of anionized polyvinylpyrrolidone to the renal system.
Biomaterials 2004;25(18):4309-15.
2004: Yoshihisa Kaneda; Yasuo Tsutsumi; Yasuo Yoshioka; Haruhiko Kamada; Yoko Yamamoto; Hiroshi Kodaira; Shin-ichi Tsunoda; Takayuki Okamoto; Yohei Mukai; Hiroko Shibata; Shinsaku Nakagawa; Tadanori Mayumi
The use of PVP as a polymeric carrier to improve the plasma half-life of drugs.
Biomaterials 2004;25(16):3259-66.
2004: Haruhiko Kamada; Yasuo Tsutsumi; Yasuo Yoshioka; Yoko Yamamoto; Hiroshi Kodaira; Shin-ichi Tsunoda; Takayuki Okamoto; Yohei Mukai; Hiroko Shibata; Shinsaku Nakagawa; Tadanori Mayumi
Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(7):2545-50.
2004: Yasuo Yoshioka; Yasuo Tsutsumi; Shinji Ikemizu; Yoko Yamamoto; Hiroko Shibata; Toshihide Nishibata; Yohei Mukai; Takayuki Okamoto; Madoka Taniai; Maki Kawamura; Yasuhiro Abe; Shinsaku Nakagawa; Satoshi Nagata; Yuriko Yamagata; Tadanori Mayumi
Optimal site-specific PEGylation of mutant TNF-alpha improves its antitumor potency.
Biochemical and biophysical research communications 2004;315(4):808-14.
2004: Yoko Yamamoto; Yasuo Tsutsumi; Yasuo Yoshioka; Haruhiko Kamada; Keiko Sato-Kamada; Takayuki Okamoto; Yohei Mukai; Hiroko Shibata; Shinsaku Nakagawa; Tadanori Mayumi
Poly(vinylpyrrolidone-co-dimethyl maleic acid) as a novel renal targeting carrier.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(2):229-37.
2004: Yasuo Yoshioka; Yasuo Tsutsumi; Haruhiko Kamada; Tetsuya Kihira; Shin-ichi Tsunoda; Yoko Yamamoto; Takayuki Okamoto; Hiroko Shibata; Yohei Mukai; Madoka Taniai; Tomoe Shimizu; Maki Kawamura; Yasuhiro Abe; Shinsaku Nakagawa; Tadanori Mayumi
Selective enhancer of tumor vascular permeability for optimization of cancer chemotherapy.
Biological & pharmaceutical bulletin 2004;27(3):437-9.
2003: Yasuo Yoshioka; Ryo Suzuki; Takayuki Okamoto; Naoki Okada; Yohei Mukai; Hiroko Shibata; Yasuo Tsutsumi; Natsuki Dohi; Noriko Okada; Shinsaku Nakagawa; Tadanori Mayumi
Combination effects of complement regulatory proteins and anti-complement polymer.
Biochimica et biophysica acta 2003;1624(1-3):54-9.
2003: Keiichi Koizumi; Yasuo Tsutsumi; Yasuo Yoshioka; Masaki Watanabe; Takayuki Okamoto; Yohei Mukai; Shinsaku Nakagawa; Tadanori Mayumi
Anti-angiogenic effects of dimethyl sulfoxide on endothelial cells.
Biological & pharmaceutical bulletin 2003;26(9):1295-8.
2003: Keiichi Koizumi; Yasuo Tsutsumi; Haruhiko Kamada; Yasuo Yoshioka; Masaki Watanabe; Yoko Yamamoto; Takayuki Okamoto; Yohei Mukai; Shinsaku Nakagawa; Yoichi Tani; Tadanori Mayumi
Incorporation of adult organ-derived endothelial cells into tumor blood vessel.
Biochemical and biophysical research communications 2003;306(1):219-24.
2003: Yasuo Yoshioka; Ryo Suzuki; Hiroaki Oka; Naoki Okada; Takayuki Okamoto; Tatsunobu Yoshioka; Yohei Mukai; Hiroko Shibata; Yasuo Tsutsumi; Shinsaku Nakagawa; Jun-ichi Miyazaki; Tadanori Mayumi
A novel cytomedical vehicle capable of protecting cells against complement.
Biochemical and biophysical research communications 2003;305(2):353-8.
2003: Yoko Yamamoto; Yasuo Tsutsumi; Yasuo Yoshioka; Toshihide Nishibata; Kyoko Kobayashi; Takayuki Okamoto; Yohei Mukai; Tomoe Shimizu; Shinsaku Nakagawa; Satoshi Nagata; Tadanori Mayumi
Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity.
Nature biotechnology 2003;21(5):546-52.
2003: Haruhiko Kamada; Yasuo Tsutsumi; Keiko Sato-Kamada; Yoko Yamamoto; Yasuo Yoshioka; Takayuki Okamoto; Shinsaku Nakagawa; Satoshi Nagata; Tadanori Mayumi
Synthesis of a poly(vinylpyrrolidone-co-dimethyl maleic anhydride) co-polymer and its application for renal drug targeting.
Nature biotechnology 2003;21(4):399-404.
2002: Ryo Suzuki; Yasuo Yoshioka; Etsuko Kitano; Tatsunobu Yoshioka; Hiroaki Oka; Takayuki Okamoto; Naoki Okada; Yasuo Tsutsumi; Shinsaku Nakagawa; Jun-ichi Miyazaki; Hajime Kitamura; Tadanori Mayumi
Development of a novel cytomedical treatment that can protect entrapped cells from host humoral immunity.
Cell transplantation 2002;11(8):787-97.