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Haruki Okamura

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Hideyuki Yamamoto; Kyosuke Yamanishi; Akifumi Yamashita; Teruo Yasunaga; Momoko Yoshida; Naohisa Goto; Hisato Matsunaga; Seiji Nishiguchi; Hiroshi Nojima; Haruki Okamura; Daisuke Okuzaki; Kazunori Shimada; Yuko Watanabe; Yunfeng Xu; Hiromichi Yamanishi
Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats.
Naoko Yamada; Koji Yamanegi; Hiroyuki Futani; Masaki Hata; Keiji Nakasho; Hideki Ohyama; Haruki Okamura; Nobuyuki Terada
Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1α-dependent manner.
Koji Yamanegi; Naoko Yamada; Junko Yamane; Satoru Fukunaga; Hiroyuki Futani; Masaki Hata; Kenta Kobayashi; Keiji Nakasho; Hideki Ohyama; Haruki Okamura; Nobuyuki Terada
Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells.

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All Publications

2013: Hideyuki Yamamoto; Kyosuke Yamanishi; Akifumi Yamashita; Teruo Yasunaga; Momoko Yoshida; Naohisa Goto; Hisato Matsunaga; Seiji Nishiguchi; Hiroshi Nojima; Haruki Okamura; Daisuke Okuzaki; Kazunori Shimada; Yuko Watanabe; Yunfeng Xu; Hiromichi Yamanishi
Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats.
International journal of molecular medicine 2013;31(5):1057-65.
2012: Naoko Yamada; Koji Yamanegi; Hiroyuki Futani; Masaki Hata; Keiji Nakasho; Hideki Ohyama; Haruki Okamura; Nobuyuki Terada
Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1α-dependent manner.
International journal of oncology 2012;41(6):2005-12.
2012: Koji Yamanegi; Naoko Yamada; Junko Yamane; Satoru Fukunaga; Hiroyuki Futani; Masaki Hata; Kenta Kobayashi; Keiji Nakasho; Hideki Ohyama; Haruki Okamura; Nobuyuki Terada
Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells.
Oncology reports 2012;28(5):1585-90.
2012: Koji Yamanegi; Naoko Yamada; Junko Yamane; Satoru Fukunaga; Hiroyuki Futani; Masaki Hata; Nahoko Kato-Kogoe; Kenta Kobayashi; Keiji Nakasho; Hideki Ohyama; Haruki Okamura; Nobuyuki Terada
Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fas- and NK cell-mediated cell death.
International journal of oncology 2012;41(1):83-91.
2012: Shin Okui; Shinji Takai; Masahiro Urade; Hideyuki Yamamoto; Yukihisa Fujita; Naomi Gamachi; Shin-ichiro Kashiwamura; Wen Li; Daisaku Miura; Mizuo Miyazaki; Haruki Okamura; Haruyasu Ueda
Cisplatin-induced acute renal failure in mice is mediated by chymase-activated angiotensin-aldosterone system and interleukin-18.
European journal of pharmacology 2012;685(1-3):149-55.
2012: Tokuyoshi Yamagiwa; Shinichi Yoshiya; Shigeo Fukunishi; Haruki Okamura; Toshiya Tachibana; Shin-Ichiro Kashiwamura
Abrogation of Treg function deteriorates rheumatoid arthritis.
Modern rheumatology / the Japan Rheumatism Association 2012;22(1):80-8.
2011: Junko Tsuda; Wen Li; Hiromichi Yamanishi; Hideyuki Yamamoto; Akico Okuda; Shuji Kubo; Zhifeng Ma; Nobuyuki Terada; Yoshimasa Tanaka; Haruki Okamura
Involvement of CD56brightCD11c+ cells in IL-18-mediated expansion of human γδ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2003-12.
2011: Shuji Kubo; Kazunori Haga; Atsuko Tamamoto; Donna J Palmer; Philip Ng; Haruki Okamura; Noriyuki Kasahara
Adenovirus-retrovirus hybrid vectors achieve highly enhanced tumor transduction and antitumor efficacy in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(1):76-82.
2010: Koji Yamanegi; Junko Yamane; Kenta Kobayashi; Nahoko Kato-Kogoe; Hideki Ohyama; Keiji Nakasho; Naoko Yamada; Masaki Hata; Toshihiro Nishioka; Satoru Fukunaga; Hiroyuki Futani; Haruki Okamura; Nobuyuki Terada
Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity.
Oncology reports 2010;24(6):1621-7.
2010: Toru Suzuki; Shuji Terao; Bishnu Acharya; Michio Naoe; Shingo Yamamoto; Haruki Okamura; Akinobu Gotoh
The antitumour effect of {gamma}{delta} T-cells is enhanced by valproic acid-induced up-regulation of NKG2D ligands.
Anticancer research 2010;30(11):4509-13.
2010: Yoshiro Naito; Takeshi Tsujino; Kana Wakabayashi; Mika Matsumoto; Mitsumasa Ohyanagi; Masataka Mitsuno; Yuji Miyamoto; Hiroyuki Hao; Seiichi Hirota; Haruki Okamura; Tohru Masuyama
Increased interleukin-18 expression in nonrheumatic aortic valve stenosis.
International journal of cardiology 2010;144(2):260-3.
2010: Kiyoshi Matsui; Haruyasu Ueda; Makoto Terada; Naoto Azuma; Haruki Okamura; Hajime Sano
Mizoribine protects against bleomycin-induced lung injury.
Modern rheumatology / the Japan Rheumatism Association 2010;20(5):471-7.
2010: Orie Saino; Akihiko Taguchi; Takayuki Nakagomi; Akiko Nakano-Doi; Shin-Ichiro Kashiwamura; Nobutaka Doe; Nami Nakagomi; Toshihiro Soma; Hiroo Yoshikawa; David M Stern; Haruki Okamura; T Matsuyama
Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke.
Journal of neuroscience research 2010;88(11):2385-97.
2010: Shuji Kubo; Yoshiko Kawasaki; Norie Yamaoka; Masatoshi Tagawa; Noriyuki Kasahara; Nobuyuki Terada; Haruki Okamura
Complete regression of human malignant mesothelioma xenografts following local injection of midkine promoter-driven oncolytic adenovirus.
The journal of gene medicine 2010;12(8):681-92.
2010: Norie Yamaoka; Yoshiko Kawasaki; Yunfeng Xu; Hideyuki Yamamoto; Nobuyuki Terada; Haruki Okamura; Shuji Kubo
Establishment of in vivo fluorescence imaging in mouse models of malignant mesothelioma.
International journal of oncology 2010;37(2):273-9.
2010: Atsushi Satake; Takayuki Inoue; Shuji Kubo; Yuki Taniguchi; Takehito Imado; Tatsuya Fujioka; Marika Horiuchi; Yunfeng Xu; Kazuhiro Ikegame; Satoshi Yoshihara; Katsuji Kaida; Hiroya Tamaki; Masaya Okada; Haruki Okamura; Hiroyasu Ogawa
Separation of antileukemic effects from graft-versus-host disease in MHC-haploidentical murine bone marrow transplantation: participation of host immune cells.
International journal of hematology 2010;91(3):485-97.
2009: Wen Li; Hideyuki Yamamoto; Shuji Kubo; Haruki Okamura
Modulation of innate immunity by IL-18.
Journal of reproductive immunology 2009;83(1-2):101-5.
2009: Chie Inokuchi; Haruyasu Ueda; Tomoya Hamaguchi; Jun-Ichiro Miyagawa; Masami Shinohara; Haruki Okamura; Mitsuyoshi Namba
Role of macrophages in the development of pancreatic islet injury in spontaneously diabetic torii rats.
Experimental animals / Japanese Association for Laboratory Animal Science 2009;58(4):383-94.
2009: Koji Yamanegi; Junko Yamane; Masaki Hata; Hideki Ohyama; Naoko Yamada; Nahoko Kato-Kogoe; Hiroyuki Futani; Keiji Nakasho; Haruki Okamura; Nobuyuki Terada
Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death.
Journal of cancer research and clinical oncology 2009;135(7):879-89.
2009: Naoko Yamada; Masaki Hata; Hideki Ohyama; Koji Yamanegi; Nahoko Kogoe; Keiji Nakasho; Hiroyuki Futani; Haruki Okamura; Nobuyuki Terada
Immunotherapy with interleukin-18 in combination with preoperative chemotherapy with ifosfamide effectively inhibits postoperative progression of pulmonary metastases in a mouse osteosarcoma model.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2009;30(4):176-84.
2008: Jun-ichi Hirata; Joji Kotani; Michiko Aoyama; Shin-ichiro Kashiwamura; Haruyasu Ueda; Yasuhiro Kuroda; Makoto Usami; Haruki Okamura; Seishiro Marukawa
A role for IL-18 in human neutrophil apoptosis.
Shock (Augusta, Ga.) 2008;30(6):628-33.
2008: Kan Miyoshi; Koichi Obata; Takashi Kondo; Haruki Okamura; Koichi Noguchi
Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(48):12775-87.
2008: Yuka Hosotani; Shin-ichiro Kashiwamura; Akiko Kimura-Shimmyo; Atsuo Sekiyama; Haruyasu Ueda; Tomohiro Ikeda; Osamu Mimura; Haruki Okamura
Interleukin-18 prevents apoptosis via PI3K/Akt pathway in normal human keratinocytes.
The Journal of dermatology 2008;35(8):514-24.
2008: Hirofumi Watanabe; Masaki Hata; Nobuyuki Terada; Haruyasu Ueda; Naoko Yamada; Koji Yamanegi; Hideki Ohyama; Michiko Kakihana; Haruki Okamura; Keiji Nakasho
Transdifferentiation into biliary ductular cells of hepatocytes transplanted into the spleen.
Pathology 2008;40(3):272-6.
2007: Wen Li; Shin-ichiro Kashiwamura; Haruyasu Ueda; Atsuo Sekiyama; Haruki Okamura
Protection of CD8+ T cells from activation-induced cell death by IL-18.
Journal of leukocyte biology 2007;82(1):142-51.
2006: Haruyasu Ueda; Shin-ichiro Kashiwamura; Atsuo Sekiyama; Takeharu Ogura; Naomi Gamachi; Haruki Okamura
Production of IL-13 in spleen cells by IL-18 and IL-12 through generation of NK-like cells.
Cytokine 2006;33(4):179-87.
2006: Atsuo Sekiyama; Haruyasu Ueda; Shin-ichiro Kashiwamura; Kensei Nishida; Seiko Yamaguchi; Hideyuki Sasaki; Yuki Kuwano; Kaori Kawai; Shigetada Teshima-Kondo; Kazuhito Rokutan; Haruki Okamura
A role of the adrenal gland in stress-induced up-regulation of cytokines in plasma.
Journal of neuroimmunology 2006;171(1-2):38-44.
2005: Atsuo Sekiyama; Haruyasu Ueda; Shin-ichiro Kashiwamura; Kensei Nishida; Kaori Kawai; Shigetada Teshima-Kondo; Kazuhito Rokutan; Haruki Okamura
IL-18; a cytokine translates a stress into medical science.
The journal of medical investigation : JMI 2005;52 Suppl():236-9.
2005: Akemi Nakatani-Okuda; Haruyasu Ueda; Shin-ichiro Kashiwamura; Atsuo Sekiyama; Akira Kubota; Yukihisa Fujita; Susumu Adachi; Yoshiyuki Tsuji; Takakuni Tanizawa; Haruki Okamura
Protection against bleomycin-induced lung injury by IL-18 in mice.
American journal of physiology. Lung cellular and molecular physiology 2005;289(2):L280-7.
2005: Atsuo Sekiyama; Haruyasu Ueda; Shin-ichiro Kashiwamura; Ryuji Sekiyama; Masatoshi Takeda; Kazuhito Rokutan; Haruki Okamura
A stress-induced, superoxide-mediated caspase-1 activation pathway causes plasma IL-18 upregulation.
Immunity 2005;22(6):669-77.
2005: Haruki Okamura
[IL-1 family (IL-1alpha/beta, IL-1Ra, IL-18), IL-16, IL-17].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 4():226-33.
2004: M Fujita; K Goto; Kaya Yoshida; Haruki Okamura; Hiroyuki Morimoto; Shinji Kito; Jinichi Fukuda; Tatsuji Haneji
Okadaic acid stimulates expression of Fas receptor and Fas ligand by activation of nuclear factor kappa-B in human oral squamous carcinoma cells.
Oral oncology 2004;40(2):199-206.
2002: Haruki Okamura; Hiroyuki Morimoto; M Fujita; Fumio Nasu; E Sasakia; Tatsuji Haneji
Suppression of Egr-1 expression in human oral squamous carcinoma cells by okadaic acid.
Oral oncology 2002;38(8):779-84.
2002: Shin-ichiro Kashiwamura; Haruyasu Ueda; Haruki Okamura
Roles of interleukin-18 in tissue destruction and compensatory reactions.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2002;25 Suppl 1():S4-11.
2001: Tomohiro Yoshimoto; Hiroko Tsutsui; Haruki Okamura; Kenji Nakanishi
Measurement of human and mouse interleukin 18.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 6():Unit 6.26.
2001: Haruki Okamura; Hiroyuki Morimoto; Tatsuji Haneji
Peplomycin-induced apoptosis in oral squamous carcinoma cells depends on bleomycin sensitivity.
Oral oncology 2001;37(4):379-85.
2000: Sukh Mahendra Singh; H Yanagawa; Masaki Hanibuchi; T Miki; Haruki Okamura; Saburo Sone
Augmentation by interleukin-18 of MHC-nonrestricted killer activity of human peripheral blood mononuclear cells in response to interleukin-12.
International journal of immunopharmacology 2000;22(1):35-43.