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Tomio Okamura

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Takashi Shimosato; Masashi Tawa; Ayman Geddawy; Takeshi Imamura; Tomio Okamura
Chronic administration of nicotine-free cigarette smoke extract impaired endothelium-dependent vascular relaxation in rats via increased vascular oxidative stress.
Masashi Tawa; Taiki Fukumoto; Mamoru Ohkita; Naoto Yamashita; Ayman Geddawy; Takeshi Imamura; Kazuhide Ayajiki; Tomio Okamura; Yasuo Matsumura
Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts.
Masashi Tawa; Kohei Yamamizu; Takashi Shimosato; Kazuhide Ayajiki; Ayman Geddawy; Takeshi Imamura; Tomio Okamura
Impairment by hypoxia or hypoxia/reoxygenation of nitric oxide-mediated relaxation in isolated monkey coronary artery: the role of intracellular superoxide.

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2012: Takashi Shimosato; Masashi Tawa; Ayman Geddawy; Takeshi Imamura; Tomio Okamura
Chronic administration of nicotine-free cigarette smoke extract impaired endothelium-dependent vascular relaxation in rats via increased vascular oxidative stress.
Journal of pharmacological sciences 2012;118(2):206-14.
2011: Masashi Tawa; Taiki Fukumoto; Mamoru Ohkita; Naoto Yamashita; Ayman Geddawy; Takeshi Imamura; Kazuhide Ayajiki; Tomio Okamura; Yasuo Matsumura
Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts.
Hypertension research : official journal of the Japanese Society of Hypertension 2011;34(2):218-24.
2011: Masashi Tawa; Kohei Yamamizu; Takashi Shimosato; Kazuhide Ayajiki; Ayman Geddawy; Takeshi Imamura; Tomio Okamura
Impairment by hypoxia or hypoxia/reoxygenation of nitric oxide-mediated relaxation in isolated monkey coronary artery: the role of intracellular superoxide.
Journal of pharmacological sciences 2011;116(2):188-96.
2011: Noboru Toda; Tomio Okamura
Modulation of renal blood flow and vascular tone by neuronal nitric oxide synthase-derived nitric oxide.
Journal of vascular research 2011;48(1):1-10.
2010: Fumio Ogawa; Masakazu Hanamitsu; Kazuhide Ayajiki; Yoshinari Aimi; Tomio Okamura; Takeshi Shimizu
Effect of nitric oxide synthase inhibitor on increase in nasal mucosal blood flow induced by sensory and parasympathetic nerve stimulation in rats.
The Annals of otology, rhinology, and laryngology 2010;119(6):424-30.
2010: Ayman Geddawy; Takashi Shimosato; Masashi Tawa; Takeshi Imamura; Tomio Okamura
Mechanism underlying endothelium-dependent relaxation by 2-methylthio-ADP in monkey cerebral artery.
Journal of pharmacological sciences 2010;114(2):180-8.
2010: Ayman Geddawy; Takashi Shimosato; Masashi Tawa; Takeshi Imamura; Tomio Okamura
Comparison of endothelium-related responses to nucleotides of dog and monkey cerebral arteries.
Journal of pharmacological sciences 2010;112(3):378-81.
2008: Kazuhide Ayajiki; Yasushi Ozeki; Chunmei Wang; Tomio Okamura
Cilostazol's effect on the response to perivascular nerve stimulation in isolated dog cerebral and mesenteric arteries.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(7):1425-33.
2008: Kazuhide Ayajiki; Toshio Kimura; Kohei Yamamizu; Tomio Okamura
Mechanisms underlying mechanical responses to Ephedra herb of isolated rabbit urinary bladder and urethra, a possible stress urinary incontinence therapeutic.
Journal of pharmacological sciences 2008;107(2):175-80.
2007: Kohei Yamamizu; Kazuya Shinozaki; Kazuhide Ayajiki; Munekazu Gemba; Tomio Okamura
Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dysfunction in rats with chronic renal failure.
Journal of cardiovascular pharmacology 2007;49(3):131-9.
2007: Kazuya Shinozaki; Yoshihiko Nishio; Kazuhide Ayajiki; Yuichi Yoshida; Masahiro Masada; Atsunori Kashiwagi; Tomio Okamura
Pitavastatin restores vascular dysfunction in insulin-resistant state by inhibiting NAD(P)H oxidase activity and uncoupled endothelial nitric oxide synthase-dependent superoxide production.
Journal of cardiovascular pharmacology 2007;49(3):122-30.
2007: Noboru Toda; Kazuhide Ayajiki; Tomio Okamura
Interaction of endothelial nitric oxide and angiotensin in the circulation.
Pharmacological reviews 2007;59(1):54-87.
2006: Tomio Okamura
[EDRF].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():244-8.
2005: Kazuya Shinozaki; Yoshihiko Nishio; Yuichi Yoshida; Daisuke Koya; Kazuhide Ayajiki; Masahiro Masada; Atsunori Kashiwagi; Tomio Okamura
Supplement of tetrahydrobiopterin by a gene transfer of GTP cyclohydrolase I cDNA improves vascular dysfunction in insulin-resistant rats.
Journal of cardiovascular pharmacology 2005;46(4):505-12.
2005: Noboru Toda; Kazuhide Ayajiki; Tomio Okamura
Nitric oxide and penile erectile function.
Pharmacology & therapeutics 2005;106(2):233-66.
2005: Kazuhide Ayajiki; Hideyuki Fujioka; Kazuya Shinozaki; Tomio Okamura
Effects of capsaicin and nitric oxide synthase inhibitor on increase in cerebral blood flow induced by sensory and parasympathetic nerve stimulation in the rat.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(5):1792-8.
2004: Kazuya Shinozaki; Kazuhide Ayajiki; Atsunori Kashiwagi; Masahiro Masada; Tomio Okamura
Malfunction of vascular control in lifestyle-related diseases: mechanisms underlying endothelial dysfunction in the insulin-resistant state.
Journal of pharmacological sciences 2004;96(4):401-5.
2004: Tomio Okamura
[Gene, regulation of synthesis, and physiological activity of nNOS].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():455-9.
2004: Kazuhide Ayajiki; Kazuya Shinozaki; Tomio Okamura
[Mechanisms of nitric oxide production].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 9():446-50.
2004: Kazuya Shinozaki; Atsunori Kashiwagi; Masahiro Masada; Tomio Okamura
Molecular mechanisms of impaired endothelial function associated with insulin resistance.
Current drug targets. Cardiovascular & haematological disorders 2004;4(1):1-11.
2004: Hideyuki Fujioka; Kazuhide Ayajiki; Kazuya Shinozaki; Tomio Okamura
Mechanisms underlying endothelium-dependent flow increase in perfused rat mesenteric vascular bed.
European journal of pharmacology 2004;485(1-3):219-25.
2004: Kazuya Shinozaki; Kazuhide Ayajiki; Yoshihiko Nishio; takeshi sugaya; Atsunori Kashiwagi; Tomio Okamura
Evidence for a causal role of the renin-angiotensin system in vascular dysfunction associated with insulin resistance.
Hypertension 2004;43(2):255-62.
2003: Toshiki Tanaka; Kazuhide Ayajiki; Hideyuki Fujioka; Noboru Toda; Tomio Okamura
Protection by hypothermia of hypoxia-induced inhibition of neurogenic vasodilation in porcine cerebral arteries.
Journal of pharmacological sciences 2003;92(2):93-9.
2003: Kazuya Shinozaki; Atsunori Kashiwagi; Masahiro Masada; Tomio Okamura
Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state.
Journal of pharmacological sciences 2003;91(3):187-91.
2003: Kazuhide Ayajiki; Hideyuki Fujioka; Noboru Toda; Shigeru Okada; Yukiko Minamiyama; Susumu Imaoka; Yoshihiko Funae; Shuji Watanabe; Akio Nakamura; Tomio Okamura
Mediation of arachidonic acid metabolite(s) produced by endothelial cytochrome P-450 3A4 in monkey arterial relaxation.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26(3):237-43.
2002: Hideyuki Fujioka; Kazuhide Ayajiki; Kazuya Shinozaki; Noboru Toda; Tomio Okamura
Mechanisms underlying endothelium-dependent, nitric oxide- and prostanoid-independent relaxation in monkey and dog coronary arteries.
Naunyn-Schmiedeberg's archives of pharmacology 2002;366(5):488-95.
2002: Kazuhide Ayajiki; Hideyuki Fujioka; Ryuzo Torii; Noboru Toda; Tomio Okamura
Endothelial and neuronal functions in cerebral and temporal arteries from monkeys fed a high-cholesterol diet.
Journal of cardiovascular pharmacology 2002;40(3):456-66.
2002: Kazuhide Ayajiki; Tomio Okamura; Kumiko Noda; Noboru Toda
Functional study on nitroxidergic nerve in isolated dog pulmonary arteries and veins.
Japanese journal of pharmacology 2002;89(2):197-200.
2002: Toshio Kimura; Kazuhide Ayajiki; Yoichi Noda; Tomio Okamura
Comparison of the responses to thrombin in monkey renal and uterine arteries.
Journal of the Society for Gynecologic Investigation 2002;9(3):146-51.
2002: Tomio Okamura; Hideyuki Fujioka; Kazuhide Ayajiki
Effects of nipradilol on alpha-adrenoceptor function in ocular arteries.
Pharmacology 2002;65(2):110-8.
2002: Kazuhide Ayajiki; Noboru Toda; Tomio Okamura
[Nitroxidergic (nitrergic) nerve and erectile dysfunction].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2002;119(1):21-8.
2002: Tomio Okamura; Kazuhide Ayajiki; Hideyuki Fujioka; Kazuya Shinozaki; Noboru Toda
Neurogenic cerebral vasodilation mediated by nitric oxide.
Japanese journal of pharmacology 2002;88(1):32-8.
2001: Kazuya Shinozaki; A Hirayama; Yoshihiko Nishio; Yuichi Yoshida; T Ohtani; Tomio Okamura; Masahiro Masada; Ryuichi Kikkawa; K Kodama; Atsunori Kashiwagi
Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress.
Journal of the American College of Cardiology 2001;38(7):1821-8.
2001: Tomio Okamura; Hideyuki Fujioka; Kazuhide Ayajiki
Effects of calcium antagonists on the nitrergic nerve function in canine corpus cavernosum.
Japanese journal of pharmacology 2001;87(3):208-13.
2001: Kazuhide Ayajiki; Hideyuki Fujioka; Tomio Okamura; Noboru Toda
Relatively selective neuronal nitric oxide synthase inhibition by 7-nitroindazole in monkey isolated cerebral arteries.
European journal of pharmacology 2001;423(2-3):179-83.
2001: Noboru Toda; Kazuhide Ayajiki; Hideyuki Fujioka; Tomio Okamura
Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries.
Journal of ethnopharmacology 2001;76(1):109-13.
2001: Kazuhide Ayajiki; Hideyuki Fujioka; K Noda; Tomio Okamura; Noboru Toda
Modifications by sumatriptan and acetylcholine of nitric oxide-mediated neurogenic dilatation in dog cerebral arteries.
European journal of pharmacology 2001;420(1):67-72.
2001: Toshio Kimura; Noboru Toda; Yoichi Noda; Tomio Okamura
Mechanisms of relaxation induced by angiotensin II in isolated canine and human uterine arteries.
Journal of cardiovascular pharmacology 2001;37(5):585-95.
2001: Takashi Kadowaki; Tomio Okamura; Hirotsugu Ueshima
[Lipid disorder and atherosclerosis caused by smoking].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 3():214-9.
2001: Tomio Okamura; Kazuhide Ayajiki; Noboru Toda
Hypothermia on NO-mediated neurogenic relaxation and on hypoxic inhibition in the response of canine cerebral arteries.
Hypertension research : official journal of the Japanese Society of Hypertension 2001;24(1):47-53.
2000: Kazuhide Ayajiki; Hideyuki Fujioka; Tomio Okamura
Mechanisms underlying endothelium-dependent, nitric oxide/prostacyclin-independent, acetylcholine-induced relaxation in canine corpus cavernosum.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(4-5):448-51.
2000: Tomio Okamura; H A Ghoneim; Kazuhide Ayajiki; E S Ammar; Noboru Toda
Mechanisms underlying contraction and relaxation induced by nerve stimulation in monkey uterine arteries.
Pharmacology 2000;61(4):251-6.
2000: Kazuhide Ayajiki; M Ozaki; M Shiomi; Tomio Okamura; Noboru Toda
Comparison of endothelium-dependent relaxation in carotid arteries from Japanese white and Watanabe heritable hyperlipidemic rabbits.
Journal of cardiovascular pharmacology 2000;36(5):622-30.
2000: Kazuhide Ayajiki; T Tanaka; Tomio Okamura; Noboru Toda
Evidence for nitroxidergic innervation in monkey ophthalmic arteries in vivo and in vitro.
American journal of physiology. Heart and circulatory physiology 2000;279(4):H2006-12.
2000: Kazuya Shinozaki; Yoshihiko Nishio; Tomio Okamura; Yuichi Yoshida; H Maegawa; H Kojima; Masahiro Masada; N Toda; Ryuichi Kikkawa; Atsunori Kashiwagi
Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats.
Circulation research 2000;87(7):566-73.
2000: Kazuya Shinozaki; Tomio Okamura; Y Nishio; Atsunori Kashiwagi; Ryuichi Kikkawa; Noboru Toda
Evaluation of endothelial free radical release by vascular tension responses in insulin-resistant rat aorta.
European journal of pharmacology 2000;394(2-3):295-9.
2000: Noboru Toda; Kazuhide Ayajiki; T Tanaka; Tomio Okamura
Preganglionic and postganglionic neurons responsible for cerebral vasodilation mediated by nitric oxide in anesthetized dogs.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(4):700-8.
2000: Noboru Toda; T Tanaka; Kazuhide Ayajiki; Tomio Okamura
Cerebral vasodilatation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anesthetized monkeys.
Neuroscience 2000;96(2):393-8.
1999: Hideyuki Fujioka; Tomio Okamura; Noboru Toda
Inhibition by adrenomedullin of amine release from adrenergic nerves in dog mesenteric arteries.
European journal of pharmacology 1999;385(2-3):155-61.
1999: Kazuya Shinozaki; Atsunori Kashiwagi; Yoshihiko Nishio; Tomio Okamura; Yuichi Yoshida; Masahiro Masada; N Toda; Ryuichi Kikkawa
Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.
Diabetes 1999;48(12):2437-45.
1999: Kazuhide Ayajiki; Tomio Okamura; Hideyuki Fujioka; S Imaoka; Yoshihiko Funae; Noboru Toda
Involvement of CYP3A-derived arachidonic acid metabolite(s) in responses to endothelium-derived K+ channel opening substance in monkey lingual artery.
British journal of pharmacology 1999;128(3):802-8.
1999: Atsunori Kashiwagi; Kazuya Shinozaki; Yoshihiko Nishio; Tomio Okamura; N Toda; Ryuichi Kikkawa
Free radical production in endothelial cells as a pathogenetic factor for vascular dysfunction in the insulin resistance state.
Diabetes research and clinical practice 1999;45(2-3):199-203.
1999: M Toda; Tomio Okamura; Kazuhide Ayajiki; Noboru Toda
Neurogenic vasoconstriction as affected by cholinergic and nitroxidergic nerves in dog ciliary and ophthalmic arteries.
Investigative ophthalmology & visual science 1999;40(8):1753-60.
1999: Tomio Okamura; Kazuhide Ayajiki; Hideyuki Fujioka; M Toda; Mineko Fujimiya; Noboru Toda
Effects of endothelial impairment by saponin on the responses to vasodilators and nitrergic nerve stimulation in isolated canine corpus cavernosum.
British journal of pharmacology 1999;127(3):802-8.
1999: Tomio Okamura; Kazuhide Ayajiki; Hideyuki Fujioka; Noboru Toda
Mechanisms underlying arginine vasopressin-induced relaxation in monkey isolated coronary arteries.
Journal of hypertension 1999;17(5):673-8.
1999: Kazuhide Ayajiki; H Hayashida; Tomio Okamura; Noboru Toda
Influence of denervation on neurogenic inhibitory response of corpus cavernosum and nitric oxide synthase histochemistry.
Brain research 1999;825(1-2):14-21.
1999: M Toda; Tomio Okamura; Mineko Fujimiya; I Azuma; Noboru Toda
Mechanisms underlying the neurogenic relaxation of isolated porcine sphincter pupillae.
Experimental eye research 1999;68(4):505-12.
1999: Tomio Okamura; Kazuhide Ayajiki; M Uchiyama; M Uehara; Noboru Toda
Neurogenic vasodilatation of canine isolated small labial arteries.
The Journal of pharmacology and experimental therapeutics 1999;288(3):1031-6.
1999: T Tanaka; Tomio Okamura; J Handa; Noboru Toda
Neurogenic vasodilation mediated by nitric oxide in porcine cerebral arteries.
Journal of cardiovascular pharmacology 1999;33(1):56-64.
1998: Tomio Okamura; Y Tanobe; Hideyuki Fujioka; Kazuhide Ayajiki; Noboru Toda
Mechanism of neurogenic relaxation and modification of the response by enteric substances in isolated dog colon.
European journal of pharmacology 1998;358(3):245-52.
1998: Kazuhide Ayajiki; Tomio Okamura; Hideyuki Fujioka; K Nakayama; K Tsuji; Noboru Toda
Functional studies on blockade by neosurugatoxin of nicotinic receptors in nitroxidergic and sensory nerve terminals and intramural ganglionic cells.
Japanese journal of pharmacology 1998;78(2):217-23.
1998: Tomio Okamura; Hideyuki Fujioka; Kazuhide Ayajiki; Noboru Toda
Modifications by superoxide-generating agent, neurotransmitters and neuromodulators of nitroxidergic nerve function in monkey cerebral arteries.
The Journal of pharmacology and experimental therapeutics 1998;286(3):1321-5.
1998: Tomio Okamura; Kazuhide Ayajiki; M Uchiyama; K Kagami; Noboru Toda
Mechanisms underlying constrictor and dilator responses to perivascular nerve stimulation in canine lingual arteries.
European journal of pharmacology 1998;354(1):43-50.
1998: Noboru Toda; M Toda; Kazuhide Ayajiki; Tomio Okamura
Cholinergic nerve function in monkey ciliary arteries innervated by nitroxidergic nerve.
The American journal of physiology 1998;274(5 Pt 2):H1582-9.
1998: Noboru Toda; Tomio Okamura
Cerebral vasodilators.
Japanese journal of pharmacology 1998;76(4):349-67.
1998: Tomio Okamura; Kazuhide Ayajiki; Noboru Toda
Monkey corpus cavernosum relaxation mediated by NO and other relaxing factor derived from nerves.
The American journal of physiology 1998;274(4 Pt 2):H1075-81.
1998: M Toda; Kazuhide Ayajiki; Tomio Okamura; I Azuma; Noboru Toda
Desmopressin-induced dog ciliary artery relaxation.
European journal of pharmacology 1998;344(2-3):197-201.
1998: S Shiraishi; Tomio Okamura; M Kodama; Noboru Toda
Mechanisms underlying the neurogenic relaxation in dog isolated hepatic arteries.
Journal of cardiovascular pharmacology 1998;31(3):372-6.
1998: Yoshikazu Sai; Kazuhide Ayajiki; Tomio Okamura; Shuichi Nosaka; Noboru Toda
Comparison of the effects of pancuronium and vecuronium in canine coronary and renal arteries.
Anesthesiology 1998;88(1):165-71.
1997: Noboru Toda; Kazuhide Ayajiki; Tomio Okamura
Effect of Ca2+/calmodulin-dependent protein kinase II inhibitors on the neurogenic cerebroarterial relaxation.
European journal of pharmacology 1997;340(1):59-65.
1997: Tomio Okamura; M Toda; Kazuhide Ayajiki; Noboru Toda
Receptor subtypes involved in relaxation and contraction by arginine vasopressin in canine isolated short posterior ciliary arteries.
Journal of vascular research 1997;34(6):464-72.
1997: Kazuhide Ayajiki; H Hayashida; Tomio Okamura; Noboru Toda
Pelvic nerve stimulation-induced pressor responses in corpus cavernosum of anesthetized dogs.
The American journal of physiology 1997;273(5 Pt 2):H2141-5.
1997: M Toda; Tomio Okamura; I Azuma; Noboru Toda
Modulation by neurogenic acetylcholine of nitroxidergic nerve function in porcine ciliary arteries.
Investigative ophthalmology & visual science 1997;38(11):2261-9.
1997: Tomio Okamura; Kazuhide Ayajiki; Noboru Toda
Hypoxia-induced inhibition of the response to nitroxidergic nerve stimulation in canine cerebral arteries.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(7):807-13.
1997: Kazuhide Ayajiki; Tomio Okamura; Noboru Toda
Flunarizine, an anti-migraine agent, impairs nitroxidergic nerve function in cerebral arteries.
European journal of pharmacology 1997;329(1):49-53.
1997: J X Zhang; Tomio Okamura; Noboru Toda
Prejunctional regulation by endogenous and exogenous acetylcholine of adrenergic nerve function in isolated canine mesenteric arteries.
Hypertension research : official journal of the Japanese Society of Hypertension 1997;20(2):119-25.
1997: Noboru Toda; Kazuhide Ayajiki; M Uchiyama; Tomio Okamura
Nitric oxide-mediated neurogenic vasodilatation in isolated monkey lingual arteries.
The American journal of physiology 1997;272(4 Pt 2):H1582-8.
1997: Tomio Okamura; J X Zhang; K Kangawa; Noboru Toda
Inhibition by adrenomedullin of the adrenergic neurogenic response in canine mesenteric arteries.
Japanese journal of pharmacology 1997;73(3):259-61.
1997: M Uchiyama; Tomio Okamura; M Uehara; Noboru Toda
Analysis of the vasodilator nerve function by nicotine in isolated dog skin artery.
European journal of pharmacology 1997;321(1):19-25.
1997: Noboru Toda; Kazuhide Ayajiki; Tomio Okamura
Inhibition of nitroxidergic nerve function by neurogenic acetylcholine in monkey cerebral arteries.
The Journal of physiology 1997;498 ( Pt 2)():453-61.
1997: S Shiraishi; Tomio Okamura; Noboru Toda
beta1-Adrenoceptor-mediated relaxation by norepinephrine in dog hepatic arteries.
Japanese journal of pharmacology 1997;73(1):101-3.
1997: Tomio Okamura; Kazuhide Ayajiki; K Kangawa; Noboru Toda
Mechanism of adrenomedullin-induced relaxation in isolated canine retinal arteries.
Investigative ophthalmology & visual science 1997;38(1):56-61.
1996: Tomio Okamura; Y Kitamura; M Uchiyama; M Toda; Kazuhide Ayajiki; Noboru Toda
Canine retinal arterial and arteriolar dilatation induced by nipradilol, a possible glaucoma therapeutic.
Pharmacology 1996;53(5):302-10.
1996: H Hayashida; H Fujimoto; K Yoshida; T Tomoyoshi; Tomio Okamura; Noboru Toda
Comparison of neurogenic contraction and relaxation in canine corpus cavernosum and penile artery and vein.
Japanese journal of pharmacology 1996;72(3):231-40.
1996: Noboru Toda; M Toda; Kazuhide Ayajiki; Tomio Okamura
Monkey central retinal artery is innervated by nitroxidergic vasodilator nerves.
Investigative ophthalmology & visual science 1996;37(11):2177-84.
1996: J X Zhang; Tomio Okamura; Noboru Toda
Pre- and postjunctional modulation by endothelin-1 of the adrenergic neurogenic response in canine mesenteric arteries.
European journal of pharmacology 1996;311(2-3):169-76.
1996: Tomio Okamura; Kazuhide Ayajiki; Noboru Toda
Neural mechanism of pressor action of nitric oxide synthase inhibitor in anesthetized monkeys.
Hypertension 1996;28(3):341-6.
1996: Noboru Toda; Kazuhide Ayajiki; Tomio Okamura
Hypercapnia relaxes cerebral arteries and potentiates neurally-induced relaxation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(5):1068-74.
1996: Noboru Toda; Tomio Okamura
Nitroxidergic nerve: regulation of vascular tone and blood flow in the brain.
Journal of hypertension 1996;14(4):423-34.
1996: H Hayashida; Tomio Okamura; T Tomoyoshi; Noboru Toda
Neurogenic nitric oxide mediates relaxation of canine corpus cavernosum.
The Journal of urology 1996;155(3):1122-7.
1995: Y Tanobe; Tomio Okamura; Masaki Fujimura; Noboru Toda
Functional role and histological demonstration of nitric-oxide-mediated inhibitory nerves in dog sphincter of Oddi.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 1995;7(4):219-27.
1995: Noboru Toda; M Uchiyama; Tomio Okamura
Prejunctional modulation of nitroxidergic nerve function in canine cerebral arteries.
Brain research 1995;700(1-2):213-8.
1995: Noboru Toda; T Kimura; Tomio Okamura
Nitroxidergic nerve stimulation relaxes human uterine vein.
Journal of the autonomic nervous system 1995;55(3):189-92.
1995: Tomio Okamura; Kazuhide Ayajiki; Noboru Toda
Basilar arterial construction caused by intracisternal NG-nitro-L-arginine in anesthetized monkeys.
Cardiovascular research 1995;30(5):663-7.
1995: Tomio Okamura; T Kimura; Noboru Toda
Neurogenic vasodilation in canine uterine and iliac arteries.
Journal of hypertension 1995;13(10):1163-8.
1995: Noboru Toda; J X Zhang; Kazuhide Ayajiki; Tomio Okamura
Mechanisms underlying endothelium-independent relaxation by acetylcholine in canine retinal and cerebral arteries.
The Journal of pharmacology and experimental therapeutics 1995;274(3):1507-12.
1995: Y Sai; Tomio Okamura; Yoshikuni Amakata; Noboru Toda
Comparison of responses of canine pulmonary artery and vein to angiotensin II, bradykinin and vasopressin.
European journal of pharmacology 1995;282(1-3):235-41.
1995: Tomio Okamura; M Uchiyama; J An; Noboru Toda
Nitric oxide-mediated neurogenic relaxation in monkey mesenteric veins.
Japanese journal of pharmacology 1995;68(4):405-11.
1995: T Kimura; Tomio Okamura; Y Yoshida; Noboru Toda
Relaxant responses to prostaglandin F2 alpha and E2 of isolated human uterine arteries.
Journal of cardiovascular pharmacology 1995;26(2):333-8.
1995: M Nishikawa; Tomio Okamura; Noboru Toda
[Effect of the novel calcium antagonist AE0047 on responses of isolated dog blood vessels to vasoconstricting agents and to nerve stimulation].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1995;106(1):19-29.
1995: Tomio Okamura; Noboru Toda
Comparison of the effect of dopamine in primate arteries and veins.
Hypertension research : official journal of the Japanese Society of Hypertension 1995;18 Suppl 1():S35-7.
1995: Tomio Okamura; S Ide; Noboru Toda
Characteristics of DQ2511-induced relaxation in isolated dog, monkey and human arteries.
Pharmacology 1995;50(6):370-9.
1995: Tomio Okamura; K Yoshida; Noboru Toda
Nitroxidergic innervation in dog and monkey renal arteries.
Hypertension 1995;25(5):1090-5.
1995: Noboru Toda; K Yoshida; Tomio Okamura
Involvement of nitroxidergic and noradrenergic nerves in the relaxation of dog and monkey temporal veins.
Journal of cardiovascular pharmacology 1995;25(5):741-7.
1995: Noboru Toda; Y Kitamura; Tomio Okamura
Functional role of nerve-derived nitric oxide in isolated dog ophthalmic arteries.
Investigative ophthalmology & visual science 1995;36(3):563-70.
1995: Y Kitamura; Tomio Okamura; Kazutaka Kani; Noboru Toda
Histamine actions in dog retinal central arteries as compared to those in middle cerebral and temporal arteries.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1995;11(2):167-76.
1994: Shoichiro Shiraishi; Tomio Okamura; A Mori; Noboru Toda
Differences in adrenergic nerve and receptor function in dog internal thoracic, coronary and mesenteric arteries.
Japanese journal of pharmacology 1994;66(4):481-8.
1994: Tomio Okamura; Noboru Toda
Mechanism underlying nicotine-induced relaxation in dog saphenous arteries.
European journal of pharmacology 1994;263(1-2):85-91.
1994: Tomio Okamura; Noboru Toda
Nitric oxide (NO)-mediated, vasodilator nerve function and its susceptibility to calcium antagonists.
Journal of the autonomic nervous system 1994;49 Suppl():S55-8.
1994: Kazuhide Ayajiki; Tomio Okamura; Noboru Toda
Neurogenic relaxations caused by nicotine in isolated cat middle cerebral arteries.
The Journal of pharmacology and experimental therapeutics 1994;270(2):795-801.
1994: K Yoshida; Tomio Okamura; Noboru Toda
Histological and functional studies on the nitroxidergic nerve innervating monkey cerebral, mesenteric and temporal arteries.
Japanese journal of pharmacology 1994;65(4):351-9.
1994: Tomio Okamura; M Yamazaki; Noboru Toda
Responses to histamine and acetylcholine in isolated monkey mesenteric veins versus arteries.
Cardiovascular research 1994;28(5):667-72.
1994: Noboru Toda; Y Kitamura; Tomio Okamura
Role of nitroxidergic nerve in dog retinal arterioles in vivo and arteries in vitro.
The American journal of physiology 1994;266(5 Pt 2):H1985-92.
1994: Tomio Okamura; Noboru Toda
Inhibition by calmodulin antagonists of the neurogenic relaxation in cerebral arteries.
European journal of pharmacology 1994;256(1):79-83.
1994: Noboru Toda; T Kimura; K Yoshida; D S Bredt; Solomon H Snyder; Y Yoshida; Tomio Okamura
Human uterine arterial relaxation induced by nitroxidergic nerve stimulation.
The American journal of physiology 1994;266(4 Pt 2):H1446-50.
1994: M Enokibori; Tomio Okamura; Noboru Toda
Mechanism underlying substance P-induced relaxation in dog isolated superficial temporal arteries.
British journal of pharmacology 1994;111(1):77-82.
1993: K Yoshida; Tomio Okamura; H Kimura; D S Bredt; Solomon H Snyder; Noboru Toda
Nitric oxide synthase-immunoreactive nerve fibers in dog cerebral and peripheral arteries.
Brain research 1993;629(1):67-72.
1993: Noboru Toda; Tomio Okamura
Responses to perivascular nerve stimulation of distal temporal arteries from dogs and monkeys.
Journal of cardiovascular pharmacology 1993;22(5):744-9.
1993: Noboru Toda; Kazuhide Ayajiki; Tomio Okamura
Endothelial modulation of contractions caused by oxyhemoglobin and NG-nitro-L-arginine in isolated dog and monkey cerebral arteries.
Stroke; a journal of cerebral circulation 1993;24(10):1584-8; discussion 1589.
1993: Tomio Okamura; M Enokibori; Noboru Toda
Neurogenic and non-neurogenic relaxations caused by nicotine in isolated dog superficial temporal artery.
The Journal of pharmacology and experimental therapeutics 1993;266(3):1416-21.
1993: Noboru Toda; M Enokibori; Tetsuya Matsumoto; Tomio Okamura
Responsiveness to dopamine of isolated epicardial coronary arteries from humans, monkeys, and dogs.
Anesthesia and analgesia 1993;77(3):526-32.
1993: Y Wang; Tomio Okamura; Noboru Toda
Mechanisms of acetylcholine-induced relaxation in dog external and internal ophthalmic arteries.
Experimental eye research 1993;57(3):275-81.
1993: Noboru Toda; Kazuhide Ayajiki; M Enokibori; Tomio Okamura
Monkey cerebral arterial relaxation caused by hypercapnic acidosis and hypertonic bicarbonate.
The American journal of physiology 1993;265(3 Pt 2):H929-33.
1993: Y Kitamura; Tomio Okamura; Kazutaka Kani; Noboru Toda
Nitric oxide-mediated retinal arteriolar and arterial dilatation induced by substance P.
Investigative ophthalmology & visual science 1993;34(10):2859-65.
1993: Noboru Toda; Kazuhide Ayajiki; Tomio Okamura
Neural mechanism underlying basilar arterial constriction by intracisternal L-NNA in anesthetized dogs.
The American journal of physiology 1993;265(1 Pt 2):H103-7.
1993: Tetsuya Matsumoto; Tomio Okamura; Masahiko Kinoshita; Noboru Toda
Interactions of nitrovasodilators and atrial natriuretic peptide in isolated dog coronary arteries.
European journal of pharmacology 1993;237(1):31-7.
1993: Kazuhide Ayajiki; Tomio Okamura; Noboru Toda
Nitric oxide mediates, and acetylcholine modulates, neurally induced relaxation of bovine cerebral arteries.
Neuroscience 1993;54(3):819-25.
1993: Noboru Toda; Kazuhide Ayajiki; Tomio Okamura
Cerebroarterial relaxations mediated by nitric oxide derived from endothelium and vasodilator nerve.
Journal of vascular research 1993;30(2):61-7.
1993: K Yoshida; Tomio Okamura; Noboru Toda
Potentiation by hypoxia of contractions caused by angiotensin II in dog and monkey cerebral arteries.
Stroke; a journal of cerebral circulation 1993;24(3):421-5; discussion 426.
1993: Y Wang; Tomio Okamura; Noboru Toda
Mechanisms of histamine-induced relaxation in external and internal ophthalmic arteries.
Investigative ophthalmology & visual science 1993;34(1):41-8.
1993: Noboru Toda; Kazuhide Ayajiki; K Yoshida; H Kimura; Tomio Okamura
Impairment by damage of the pterygopalatine ganglion of nitroxidergic vasodilator nerve function in canine cerebral and retinal arteries.
Circulation research 1993;72(1):206-13.
1993: Noboru Toda; Y Kitamura; Tomio Okamura
Neural mechanism of hypertension by nitric oxide synthase inhibitor in dogs.
Hypertension 1993;21(1):3-8.
1992: Tomio Okamura; Tetsuya Matsumoto; F Ikemoto; Noboru Toda
Mechanisms of the biphasic responses to endothelin-3 in dog coronary arteries.
British journal of pharmacology 1992;107(4):1037-41.
1992: Kazuhide Ayajiki; Tomio Okamura; Noboru Toda
Involvement of nitric oxide in endothelium-dependent, phasic relaxation caused by histamine in monkey cerebral arteries.
Japanese journal of pharmacology 1992;60(4):357-62.
1992: Tomio Okamura; Y Wang; Noboru Toda
Local generation and action of angiotensin II in dog iris sphincter muscle.
Experimental eye research 1992;55(4):563-8.
1992: Tomio Okamura; M Nishikawa; K Yoshida; Noboru Toda
AE0047, a new dihydropyridine Ca2+ entry blocker, inhibits the responses to adrenergic nerve stimulation and substance P in dog mesenteric arteries.
European journal of pharmacology 1992;220(1):27-33.
1992: Noboru Toda; Tomio Okamura
[Neurotransmission and nitric oxide (NO)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1992;100(3):173-82.
1992: Noboru Toda; Tomio Okamura
Different susceptibility of vasodilator nerve, endothelium and smooth muscle functions to Ca++ antagonists in cerebral arteries.
The Journal of pharmacology and experimental therapeutics 1992;261(1):234-9.
1992: Noboru Toda; Kazuhide Ayajiki; H Toda; Y Hatano; Tomio Okamura
Mechanism underlying mannitol-induced relaxation in isolated monkey cerebral arteries.
The American journal of physiology 1992;262(3 Pt 2):H897-902.
1992: Noboru Toda; Tomio Okamura
Mechanism of neurally induced monkey mesenteric artery relaxation and contraction.
Hypertension 1992;19(2):161-6.
1992: Noboru Toda; H Baba; Y Tanobe; Tomio Okamura
Mechanism of relaxation induced by K+ and nicotine in dog duodenal longitudinal muscle.
The Journal of pharmacology and experimental therapeutics 1992;260(2):697-701.
1992: Tomio Okamura; Yoshinari Aimi; H Kimura; K Murakami; Noboru Toda
Existence of renin in the endothelium of human artery.
Journal of hypertension 1992;10(1):49-53.
1991: Noboru Toda; Tomio Okamura
Reciprocal regulation by putatively nitroxidergic and adrenergic nerves of monkey and dog temporal arterial tone.
The American journal of physiology 1991;261(6 Pt 2):H1740-5.
1991: Noboru Toda; Tomio Okamura
Role of nitric oxide in neurally induced cerebroarterial relaxation.
The Journal of pharmacology and experimental therapeutics 1991;258(3):1027-32.
1991: Tomio Okamura; M Yamazaki; Noboru Toda
Responses to dopamine of isolated human and monkey veins compared with those of the arteries.
The Journal of pharmacology and experimental therapeutics 1991;258(1):275-9.
1991: M Inoue; Tomio Okamura; Noboru Toda
Influence of methylene blue and oxyhemoglobin on mammalian vascular responses to sodium nitroprusside and nitroglycerin.
Archives internationales de pharmacodynamie et de thérapie 1991;311():104-21.
1991: Noboru Toda; M Kawakami; M Yamazaki; Tomio Okamura
Comparison of endothelium-dependent responses of monkey cerebral and temporal arteries.
British journal of pharmacology 1991;102(4):805-10.
1991: Noboru Toda; K Yoshida; Tomio Okamura
Analysis of the potentiating action of N(G)-nitro-L-arginine on the contraction of the dog temporal artery elicited by transmural stimulation of noradrenergic nerves.
Naunyn-Schmiedeberg's archives of pharmacology 1991;343(2):221-4.
1990: Noboru Toda; Tomio Okamura
Mechanism underlying the response to vasodilator nerve stimulation in isolated dog and monkey cerebral arteries.
The American journal of physiology 1990;259(5 Pt 2):H1511-7.
1990: Noboru Toda; Tomio Okamura
Possible role of nitric oxide in transmitting information from vasodilator nerve to cerebroarterial muscle.
Biochemical and biophysical research communications 1990;170(1):308-13.
1990: Tomio Okamura; K Yoshida; Noboru Toda
Suppression by methylene blue of prostaglandin I2 synthesis in isolated dog renal arteries.
The Journal of pharmacology and experimental therapeutics 1990;254(1):198-203.
1990: Noboru Toda; H Baba; Tomio Okamura
Role of nitric oxide in non-adrenergic, non-cholinergic nerve-mediated relaxation in dog duodenal longitudinal muscle strips.
Japanese journal of pharmacology 1990;53(2):281-4.
1990: Noboru Toda; Tomio Okamura
[Endothelium-derived relaxing factor (EDRF)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1990;95(6):295-308.
1990: Noboru Toda; Tomio Okamura
Comparison of the response to 5-carboxamidotryptamine and serotonin in isolated human, monkey and dog coronary arteries.
The Journal of pharmacology and experimental therapeutics 1990;253(2):676-82.
1990: Noboru Toda; Tomio Okamura
Beta adrenoceptor subtype in isolated human, monkey and dog epicardial coronary arteries.
The Journal of pharmacology and experimental therapeutics 1990;253(2):518-24.
1990: Tomio Okamura; H Okunishi; Kazuhide Ayajiki; Noboru Toda
Conversion of angiotensin I to angiotensin II in dog isolated renal artery: role of two different angiotensin II-generating enzymes.
Journal of cardiovascular pharmacology 1990;15(3):353-9.
1990: Noboru Toda; Y Minami; Tomio Okamura
Inhibitory effects of L-NG-nitro-arginine on the synthesis of EDRF and the cerebroarterial response to vasodilator nerve stimulation.
Life sciences 1990;47(4):345-51.
1990: Noboru Toda; S Inoue; H Okunishi; Tomio Okamura
Intra- and extraluminally-applied acetylcholine on the vascular tone or the response to transmural stimulation in dog isolated mesenteric arteries.
Naunyn-Schmiedeberg's archives of pharmacology 1990;341(1-2):30-6.
1990: Noboru Toda; Tomio Okamura
Modification by L-NG-monomethyl arginine (L-NMMA) of the response to nerve stimulation in isolated dog mesenteric and cerebral arteries.
Japanese journal of pharmacology 1990;52(1):170-3.
1990: Noboru Toda; K Ayaziki; Tomio Okamura
Modifications by endogenous prostaglandins of angiotensin II-induced contractions in dog and monkey cerebral and mesenteric arteries.
The Journal of pharmacology and experimental therapeutics 1990;252(1):374-9.
1989: Noboru Toda; Tomio Okamura
Endothelium-dependent and -independent responses to vasoactive substances of isolated human coronary arteries.
The American journal of physiology 1989;257(3 Pt 2):H988-95.
1989: Tomio Okamura; S Inoue; Noboru Toda
Action of atrial natriuretic peptide (ANP) on dog cerebral arteries: evidence that neurogenic relaxation is not mediated by release of ANP.
British journal of pharmacology 1989;97(4):1258-64.
1989: S Inoue; K Bian; Tomio Okamura; H Okunishi; Noboru Toda
Mechanisms of action of eperisone on isolated dog saphenous arteries and veins.
Japanese journal of pharmacology 1989;50(3):271-82.
1989: Tomio Okamura; S Inoue; Y Minami; H Okunishi; Noboru Toda
Role of endothelium in the response to prostaglandin H2 in isolated dog arteries.
Japanese journal of pharmacology 1989;49(4):511-21.
1989: Tomio Okamura; Y Minami; Noboru Toda
Endothelium-dependent and -independent mechanisms of action of acetylcholine in monkey and dog isolated arteries.
Pharmacology 1989;38(5):279-88.
1989: Noboru Toda; H Okunishi; Tomio Okamura
Responses to dopamine of isolated human gastroepiploic arteries.
Archives internationales de pharmacodynamie et de thérapie 1989;297():86-97.
1989: Tomio Okamura; Noboru Toda
Different involvement of endothelium-derived relaxing factor and prostacyclin in vasodilator response to bradykinin in isolated dog blood vessels.
Advances in experimental medicine and biology 1989;247A():429-34.
1988: W Lu; Tomio Okamura; K Bian; A Inatomi; Noboru Toda
Prostaglandins involved in contractions by angiotensin II and bradykinin of isolated dog sphincter pupillae.
British journal of pharmacology 1988;95(2):544-50.
1988: Noboru Toda; S Inoue; Tomio Okamura; H Okunishi
Mechanism underlying relaxations caused by prostaglandins and thromboxane A2 analog in isolated dog arteries.
Journal of cardiovascular pharmacology 1988;11(3):354-62.
1988: Tomio Okamura; M Nakajima; Noboru Toda
Neuroeffector actions of thromboxane B2 in dog isolated mesenteric arteries.
British journal of pharmacology 1988;93(2):367-74.
1988: Noboru Toda; S Inoue; K Bian; Tomio Okamura
Endothelium-dependent and independent responses to prostaglandin H2 and arachidonic acid in isolated dog cerebral arteries.
The Journal of pharmacology and experimental therapeutics 1988;244(1):297-302.
1987: H Okunishi; M Miyazaki; Tomio Okamura; Noboru Toda
Different distribution of two types of angiotensin II-generating enzymes in the aortic wall.
Biochemical and biophysical research communications 1987;149(3):1186-92.