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William Okamura

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Elaine D Collins; June E Bishop; Craig M Bula; Alejandra Acevedo; William H Okamura; Anthony W Norman
Effect of 25-hydroxyl group orientation on biological activity and binding to the 1alpha,25-dihydroxy vitamin D3 receptor.
Anthony W Norman; Mathew T Mizwicki; William H Okamura
Ligand structure-function relationships in the vitamin D endocrine system from the perspective of drug development (including cancer treatment).
Anthony W Norman; William H Okamura; June E Bishop; Helen L Henry
Update on biological actions of 1alpha,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3.

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All Publications

2005: Elaine D Collins; June E Bishop; Craig M Bula; Alejandra Acevedo; William H Okamura; Anthony W Norman
Effect of 25-hydroxyl group orientation on biological activity and binding to the 1alpha,25-dihydroxy vitamin D3 receptor.
The Journal of steroid biochemistry and molecular biology 2005;94(4):279-88.
2003: Anthony W Norman; Mathew T Mizwicki; William H Okamura
Ligand structure-function relationships in the vitamin D endocrine system from the perspective of drug development (including cancer treatment).
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;164():55-82.
2002: Anthony W Norman; William H Okamura; June E Bishop; Helen L Henry
Update on biological actions of 1alpha,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3.
Molecular and cellular endocrinology 2002;197(1-2):1-13.
2002: Hang Shi; Anthony W Norman; William H Okamura; Anindita Sen; Michael B Zemel
1alpha,25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(13):1808-10.
2002: Anthony W Norman; June E Bishop; Craig M Bula; Christopher J Olivera; Mathew T Mizwicki; Laura P Zanello; Hitoshi Ishida; William H Okamura
Molecular tools for study of genomic and rapid signal transduction responses initiated by 1 alpha,25(OH)(2)-vitamin D(3).
Steroids 2002;67(6):457-66.
2002: William H Okamura; Gui-Dong Zhu; David K Hill; Richard J Thomas; Kerstin Ringe; Dan Borchardt; Anthony W Norman; Leonard J Mueller
Synthesis and NMR studies of (13)C-labeled vitamin D metabolites.
The Journal of organic chemistry 2002;67(5):1637-50.
2002: Rena Hayashi; Susana Fernández; William H Okamura
An 8pi electron electrocyclization leading to a 9,19-methano-bridged analogue of 1 alpha,25-dihydroxyvitamin D3.
Organic letters 2002;4(5):851-4.
2001: H Shi; Anthony W Norman; William H Okamura; A Sen; Michael B Zemel
1alpha,25-Dihydroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2751-3.
2001: G Satyanarayana Reddy; KR Muralidharan; William H Okamura; Kou-Yi Tserng; J A McLane
Metabolism of 1alpha,25-dihydroxyvitamin D(3) and its C-3 epimer 1alpha,25-dihydroxy-3-epi-vitamin D(3) in neonatal human keratinocytes.
Steroids 2001;66(3-5):441-50.
2001: William H Okamura; S Do; H Kim; S Jeganathan; T Vu; G D Zhu; Anthony W Norman
Conformationally restricted mimics of vitamin D rotamers.
Steroids 2001;66(3-5):239-47.
2001: Anthony W Norman; Helen L Henry; June E Bishop; X D Song; Craig M Bula; William H Okamura
Different shapes of the steroid hormone 1alpha,25(OH)(2)-vitamin D(3) act as agonists for two different receptors in the vitamin D endocrine system to mediate genomic and rapid responses.
Steroids 2001;66(3-5):147-58.
2001: Anthony W Norman; Seiichi Ishizuka; William H Okamura
Ligands for the vitamin D endocrine system: different shapes function as agonists and antagonists for genomic and rapid response receptors or as a ligand for the plasma vitamin D binding protein.
The Journal of steroid biochemistry and molecular biology 2001;76(1-5):49-59.
2000: Anthony W Norman; Percy Manchand; Milan R Uskokovic; William H Okamura; J A Takeuchi; June E Bishop; Junichi Hisatake; H Phillip Koeffler; Sara Peleg
Characterization of a novel analogue of 1alpha,25(OH)(2)-vitamin D(3) with two side chains: interaction with its nuclear receptor and cellular actions.
Journal of medicinal chemistry 2000;43(14):2719-30.
1999: Anthony W Norman; D Adams; Elaine D Collins; William H Okamura; Robert J Fletterick
Three-dimensional model of the ligand binding domain of the nuclear receptor for 1alpha,25-dihydroxy-vitamin D(3).
Journal of cellular biochemistry 1999;74(3):323-33.
1999: Mei-Ling Siu-Caldera; Hiroko Sekimoto; AS Weiskopf; Paul Vouros; KR Muralidharan; William H Okamura; J Bishop; Anthony W Norman; M R Uskoković; inge schuster; G Satyanarayana Reddy
Production of 1alpha,25-dihydroxy-3-epi-vitamin D3 in two rat osteosarcoma cell lines (UMR 106 and ROS 17/2.8): existence of the C-3 epimerization pathway in ROS 17/2.8 cells in which the C-24 oxidation pathway is not expressed.
Bone 1999;24(5):457-63.
1999: Hiroko Sekimoto; Mei-Ling Siu-Caldera; AS Weiskopf; Paul Vouros; KR Muralidharan; William H Okamura; Milan R Uskokovic; G Satyanarayana Reddy
1alpha,25-dihydroxy-3-epi-vitamin D3: in vivo metabolite of 1alpha,25-dihydroxyvitamin D3 in rats.
FEBS letters 1999;448(2-3):278-82.
1999: Alex J Brown; C Ritter; Eduardo Slatopolsky; KR Muralidharan; William H Okamura; G Satyanarayana Reddy
1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone secretion.
Journal of cellular biochemistry 1999;73(1):106-13.
1999: Anthony W Norman; X Song; Laura P Zanello; Craig M Bula; William H Okamura
Rapid and genomic biological responses are mediated by different shapes of the agonist steroid hormone, 1alpha,25(OH)2vitamin D3.
Steroids 1999;64(1-2):120-8.
1998: X Song; June E Bishop; William H Okamura; Anthony W Norman
Stimulation of phosphorylation of mitogen-activated protein kinase by 1alpha,25-dihydroxyvitamin D3 in promyelocytic NB4 leukemia cells: a structure-function study.
Endocrinology 1998;139(2):457-65.
1997: Anthony W Norman; William H Okamura; M W Hammond; June E Bishop; M C Dormanen; R Bouillon; H van Baelen; Amy L Ridall; E Daane; R Khoury; M C Farach-Carson
Comparison of 6-s-cis- and 6-s-trans-locked analogs of 1alpha,25-dihydroxyvitamin D3 indicates that the 6-s-cis conformation is preferred for rapid nongenomic biological responses and that neither 6-s-cis- nor 6-s-trans-locked analogs are preferred for genomic biological responses.
Molecular endocrinology (Baltimore, Md.) 1997;11(10):1518-31.
1997: KR Muralidharan; Melissa A Rowland-Goldsmith; A S Lee; G Park; Anthony W Norman; Helen L Henry; William H Okamura
Inhibitors of 25-hydroxyvitamin D3-1alpha-hydroxylase: thiavitamin D analogs and biological evaluation.
The Journal of steroid biochemistry and molecular biology 1997;62(1):73-8.
1996: Anthony W Norman; June E Bishop; E D Collins; E G Seo; D P Satchell; M C Dormanen; S B Zanello; Mary C Farach-Carson; Roger Bouillon; William H Okamura
Differing shapes of 1 alpha,25-dihydroxyvitamin D3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor: a status report.
The Journal of steroid biochemistry and molecular biology 1996;56(1-6 Spec No):13-22.
1995: William H Okamura; M M Midland; Anthony W Norman; M W Hammond; M C Dormanen; Ilka Nemere
Biochemical significance of the 6-s-cis conformation of the steroid hormone 1 alpha,25-dihydroxyvitamin D3 based on the provitamin D skeleton.
Annals of the New York Academy of Sciences 1995;761():344-8.
1995: William H Okamura; M M Midland; M W Hammond; N Abd Rahman; M C Dormanen; Ilka Nemere; Anthony W Norman
Chemistry and conformation of vitamin D molecules.
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):603-13.
1995: R Bouillon; William H Okamura; Anthony W Norman
Structure-function relationships in the vitamin D endocrine system.
Endocrine reviews 1995;16(2):200-57.
1994: Ilka Nemere; M C Dormanen; M W Hammond; William H Okamura; Anthony W Norman
Identification of a specific binding protein for 1 alpha,25-dihydroxyvitamin D3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachia.
The Journal of biological chemistry 1994;269(38):23750-6.
1994: June E Bishop; E D Collins; William H Okamura; Anthony W Norman
Profile of ligand specificity of the vitamin D binding protein for 1 alpha,25-dihydroxyvitamin D3 and its analogs.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(8):1277-88.
1994: D F Maynard; W G Trankle; Anthony W Norman; William H Okamura
14-epi stereoisomers of 25-hydroxy- and 1 alpha,25-dihydroxyvitamin D3: synthesis, isomerization to previtamins, and biological studies.
Journal of medicinal chemistry 1994;37(15):2387-93.
1994: M C Dormanen; June E Bishop; M W Hammond; William H Okamura; Ilka Nemere; Anthony W Norman
Nonnuclear effects of the steroid hormone 1 alpha,25(OH)2-vitamin D3: analogs are able to functionally differentiate between nuclear and membrane receptors.
Biochemical and biophysical research communications 1994;201(1):394-401.
1993: Anthony W Norman; Roger Bouillon; Mary C Farach-Carson; June E Bishop; L X Zhou; Ilka Nemere; J Zhao; KR Muralidharan; William H Okamura
Demonstration that 1 beta,25-dihydroxyvitamin D3 is an antagonist of the nongenomic but not genomic biological responses and biological profile of the three A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D3.
The Journal of biological chemistry 1993;268(27):20022-30.
1993: Anthony W Norman; I N Sergeev; June E Bishop; William H Okamura
Selective biological response by target organs (intestine, kidney, and bone) to 1,25-dihydroxyvitamin D3 and two analogues.
Cancer research 1993;53(17):3935-42.
1993: Anthony W Norman; William H Okamura; Mary C Farach-Carson; K Allewaert; D Branisteanu; Ilka Nemere; KR Muralidharan; Roger Bouillon
Structure-function studies of 1,25-dihydroxyvitamin D3 and the vitamin D endocrine system. 1,25-dihydroxy-pentadeuterio-previtamin D3 (as a 6-s-cis analog) stimulates nongenomic but not genomic biological responses.
The Journal of biological chemistry 1993;268(19):13811-9.
1992: Anthony W Norman; Ilka Nemere; KR Muralidharan; William H Okamura
1 beta, 25 (OH)2-vitamin D3 is an antagonist of 1 alpha,25 (OH)2-vitamin D3 stimulated transcaltachia (the rapid hormonal stimulation of intestinal calcium transport).
Biochemical and biophysical research communications 1992;189(3):1450-6.
1992: William H Okamura; J A Palenzuela; J Plumet; M M Midland
Vitamin D: structure-function analyses and the design of analogs.
Journal of cellular biochemistry 1992;49(1):10-8.
1991: B Figadère; Anthony W Norman; Helen L Henry; H Phillip Koeffler; J Y Zhou; William H Okamura
Arocalciferols: synthesis and biological evaluation of aromatic side-chain analogues of 1 alpha,25-dihydroxyvitamin D3(1a).
Journal of medicinal chemistry 1991;34(8):2452-63.
1991: J Y Zhou; Anthony W Norman; M Akashi; D L Chen; M R Uskokovic; J M Aurrecoechea; W G Dauben; William H Okamura; H Phillip Koeffler
Development of a novel 1,25(OH)2-vitamin D3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism.
Blood 1991;78(1):75-82.
1991: Helen L Henry; S Fried; G Y Shen; S A Barrack; William H Okamura
Effect of three A-ring analogs of 1 alpha,25-dihydroxyvitamin D3 on 25-OH-D3-1 alpha-hydroxylase in isolated mitochondria and on 25-hydroxyvitamin D3 metabolism in cultured kidney cells.
The Journal of steroid biochemistry and molecular biology 1991;38(6):775-9.
1983: E Mayer; J E Bishop; R A Chandraratna; William H Okamura; J R Kruse; G Popjak; N Ohnuma; A W Norman
Isolation and identification of 1,25-dihydroxy-24-oxo-vitamin D3 and 1,23,25-trihydroxy-24-oxo-vitamin D3. New metabolites of vitamin D3 produced by a C-24 oxidation pathway of metabolism for 1,25-dihydroxyvitamin D3 present in intestine and kidney.
The Journal of biological chemistry 1983;258(22):13458-65.
1983: E Mayer; G Satyanarayana Reddy; R A Chandraratna; William H Okamura; J R Kruse; G Popjàk; J E Bishop; A W Norman
23,25-Dihydroxy-24-oxovitamin D3: a metabolite of vitamin D3 made in the kidney.
Biochemistry 1983;22(8):1798-805.
1981: E Mayer; S Kadowaki; William H Okamura; N Ohnuma; G A Leyes; H Schmidt-Gayk; A W Norman
Studies on the mode of action of calciferol-XXXV. Comparison of the biochemical properties and ligand specificities of receptors and antibodies for 1,25-dihydroxyvitamin D3.
Journal of steroid biochemistry 1981;15():145-51.