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Hideyuki Okano

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Ophelia Veraitch; Shinya Yamanaka; Hideyuki Okano; Takashi Sasaki; Wado Akamatsu; Masayuki Amagai; Yoichi Imaizumi; Tetsuro Kobayashi; Manabu Ohyama
Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo.
Kanehiro Fujiyoshi; Keigo Hikishima; Yuji Komaki; Tsunehiko Konomi; Suketaka Momoshima; Masaya Nakamura; Yoshiaki Toyama; Osahiko Tsuji; Masayuki Yamada; Hideyuki Okano
Diffusion tensor imaging and tractography of the spinal cord: from experimental studies to clinical application.
Akio Iwanami; Issay Kitabayashi; Jun Kohyama; Tomoo Matsutani; Alvaro Assuncao; Webster K Cavenee; Timothy F Cloughesy; Julie Dang; Frank B Furnari; Beatrice Gini; Ali Nael; Masaya Nakamura; Hideyuki Okano; Yoshiaki Toyama; Huijun Yang; Ciro Zanca; Shaojun Zhu; Paul S Mischel
PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies.

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2013: Ophelia Veraitch; Shinya Yamanaka; Hideyuki Okano; Takashi Sasaki; Wado Akamatsu; Masayuki Amagai; Yoichi Imaizumi; Tetsuro Kobayashi; Manabu Ohyama
Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo.
The Journal of investigative dermatology 2013;133(6):1479-88.
2013: Kanehiro Fujiyoshi; Keigo Hikishima; Yuji Komaki; Tsunehiko Konomi; Suketaka Momoshima; Masaya Nakamura; Yoshiaki Toyama; Osahiko Tsuji; Masayuki Yamada; Hideyuki Okano
Diffusion tensor imaging and tractography of the spinal cord: from experimental studies to clinical application.
Experimental neurology 2013;242():74-82.
2013: Akio Iwanami; Issay Kitabayashi; Jun Kohyama; Tomoo Matsutani; Alvaro Assuncao; Webster K Cavenee; Timothy F Cloughesy; Julie Dang; Frank B Furnari; Beatrice Gini; Ali Nael; Masaya Nakamura; Hideyuki Okano; Yoshiaki Toyama; Huijun Yang; Ciro Zanca; Shaojun Zhu; Paul S Mischel
PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(11):4339-44.
2013: Shin Hatou; Kazunari Higa; Emi Inagaki; Hideyuki Miyashita; Hideyuki Okano; Kazuo Tsubota; Satoru Yoshida; Shigeto Shimmura
Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/β-catenin signaling.
Stem cells and development 2013;22(5):828-39.
2013: Hideyuki Okano; Osahiko Tsuji; Shinya Yamanaka; Kenji Yoshida; Eiji Ikeda; Masaya Nakamura; Satoshi Nori; Yohei Okada; Kyoko Miura
Steps toward safe cell therapy using induced pluripotent stem cells.
Circulation research 2013;112(3):523-33.
2013: Morito Takano; Yoshiaki Toyama; Osahiko Tsuji; Hideyuki Okano; Kanehiro Fujiyoshi; Keigo Hikishima; Yuji Komaki; Tsunehiko Konomi; Masaya Nakamura
In vivo tracing of neural tracts in tiptoe walking Yoshimura mice by diffusion tensor tractography.
Spine 2013;38(2):E66-72.
2013: Shigeki Ohta; Hideyuki Okano; Wado Akamatsu; Yoichi Imaizumi; Yutaka Kawakami
Generation of human melanocytes from induced pluripotent stem cells.
Methods in molecular biology (Clifton, N.J.) 2013;989():193-215.
2013: Masaya Nakamura; Hideyuki Okano
Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells.
Cell research 2013;23(1):70-80.
2012: Tsunehiko Konomi; Kanehiro Fujiyoshi; Keigo Hikishima; Yuji Komaki; Hideyuki Okano; Hirotaka James Okano; Yoshiaki Toyama; Osahiko Tsuji; Masaya Nakamura
Conditions for quantitative evaluation of injured spinal cord by in vivo diffusion tensor imaging and tractography: preclinical longitudinal study in common marmosets.
NeuroImage 2012;63(4):1841-53.
2012: Hideyuki Okano; Keigo Hikishima; Atsushi Iriki; Erika Sasaki
The common marmoset as a novel animal model system for biomedical and neuroscience research applications.
Seminars in fetal & neonatal medicine 2012;17(6):336-40.
2012: Takehiko Takagi; Yoshiaki Toyama; Ken Ishii; Yu Kimura; Hideyuki Okano; Hirotaka J Okano; Harukazu Saito; Shinsuke Shibata; Yasuhiko Tabata; Masaya Nakamura
Sustained bFGF-release tubes for peripheral nerve regeneration: comparison with autograft.
Plastic and reconstructive surgery 2012;130(4):866-76.
2012: Takashi Sasaki; Atsuhito Seki; Atsushi Shimizu; Aiko Shiohama; Makoto Suematsu; Keiji Tanese; Masayuki Amagai; Asami Hirakiyama; Akira Ishiko; Kenji Kabashima; Masamitsu Kuwahara; Shun-ichi Miyakawa; Hironori Niizeki; Hideyuki Okano; Torayuki Okuyama; Atsushi Otsuka; Jun-ichi Sakabe; Jun Kudoh
Identification of mutations in the prostaglandin transporter gene SLCO2A1 and its phenotype-genotype correlation in Japanese patients with pachydermoperiostosis.
Journal of dermatological science 2012;68(1):36-44.
2012: Gulayse Ince-Dunn; Kirk B Jensen; Aldo Mele; Jeffrey L Noebels; Hideyuki Okano; Hirotaka J Okano; Woong-Yang Park; Jernej Ule; Chingwen Yang; Jong Yoo; Chaolin Zhang; Ru Zhong; John Fak; Margaret Herre; Robert B Darnell
Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability.
Neuron 2012;75(6):1067-80.
2012: Satoru Matsuda; Yumi Matsuzaki; Hiroyuki Aburatani; Akinori Akaike; Ken-ichiro Kuwako; Hirotaka James Okano; Yumiko Saga; Hachiro Sugimoto; Shuichi Tsutsumi; Hideyuki Okano
Sox21 promotes hippocampal adult neurogenesis via the transcriptional repression of the Hes5 gene.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(36):12543-57.
2012: Daisuke Ito; Hideyuki Okano; Norihiro Suzuki
Accelerating progress in induced pluripotent stem cell research for neurological diseases.
Annals of neurology 2012;72(2):167-74.
2012: Satoshi Suyama; Kazunobu Sawamoto; Takehiko Sunabori; Christian Gachet; Hiroaki Kanki; Schuichi Koizumi; Hideyuki Okano
Purinergic signaling promotes proliferation of adult mouse subventricular zone cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(27):9238-47.
2012: Masaya Nakamura; Satoshi Nori; Yoshiaki Toyama; Osahiko Tsuji; Hideyuki Okano
Cell transplantation for spinal cord injury focusing on iPSCs.
Expert opinion on biological therapy 2012;12(7):811-21.
2012: Masanori Sakaguchi; Hideyuki Okano
Neural stem cells, adult neurogenesis, and galectin-1: from bench to bedside.
Developmental neurobiology 2012;72(7):1059-67.
2012: Shigeki Ohta; Hideyuki Okano; Raita Fukaya; Satoshi Inoue; Yonehiro Kanemura; Yutaka Kawakami; Aya Misawa; Masahiro Toda
Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells.
Journal of cell science 2012;125(Pt 13):3210-20.
2012: Shinsuke Shibata; Masahiko Umei; Masato Yano; Hironori Kawahara; Shinji Makino; Hideyuki Okano
Characterization of the RNA-binding protein Musashi1 in zebrafish.
Brain research 2012;1462():162-73.
2012: Satsuki Mochizuki; Hitoshi Abe; Hideyuki Okano; Hirotaka James Okano; Aya Sasaki; Masayuki Shimoda; Kenji Soejima; Yasunori Okada
Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor.
Journal of the National Cancer Institute 2012;104(12):906-22.
2012: Takeshi Matsui; Yumi Matsuzaki; Masaya Nakamura; Hideyuki Okano; Soichiro Ono; Morito Takano; Yoshiaki Toyama; Kenji Yoshida; Chikako Fujisaki; Wado Akamatsu
Neural stem cells directly differentiated from partially reprogrammed fibroblasts rapidly acquire gliogenic competency.
Stem cells (Dayton, Ohio) 2012;30(6):1109-19.
2012: Zachary Yu-Ching Lin; Ryusuke Nakajima; Masanori Imamura; Hirotaka James Okano; Chiaki Sano; Erika Sasaki; Tomoko Suzuki; Yuji Takehara; Rie Yamadera; Hideyuki Okano
Molecular signatures to define spermatogenic cells in common marmoset (Callithrix jacchus).
Reproduction (Cambridge, England) 2012;143(5):597-609.
2012: Takako Ohyama; Hideyuki Okano; Kengo Tsuda; Toshio Yamazaki; Takao Imai; Naohiro Kobayashi; Takashi Nagata; Masato Katahira
Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions.
Nucleic acids research 2012;40(7):3218-31.
2012: Eun Kyung Lee; Jennifer L Martindale; Evi M Mercken; Hideyuki Okano; Nora I Perrone-Bizzozero; Sarah S Subaran; Kumiko Tominaga; Xiaoling Yang; Wado Akamatsu; Olga D Carlson; Rafael de Cabo; Josephine M Egan; Wook Kim; Rohit N Kulkarni; Myriam Gorospe
RNA-binding protein HuD controls insulin translation.
Molecular cell 2012;45(6):826-35.
2012: Chikako Hara-Miyauchi; Takeshi Imamura; Yumi Matsuzaki; Atsushi Miyawaki; Masaya Nakamura; Seiji Okada; Chihiro Akazawa; Takashi Fukano; Aki Hanyu; Hirotaka James Okano; Osahiko Tsuji; Akimasa Yasuda; Hideyuki Okano
Bioluminescent system for dynamic imaging of cell and animal behavior.
Biochemical and biophysical research communications 2012;419(2):188-93.
2012: Ayako Nakamura-Ishizu; Hideyuki Okano; Yuji Okuno; Yoko Ozawa; Toshio Suda; Kazuo Tsubota; Nobuhito Goda; Kazuo Kishi; Toshihide Kurihara; Yoshiaki Kubota
The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner.
Developmental biology 2012;363(1):106-14.
2012: Morito Takano; Yoshiaki Toyama; Akimasa Yasuda; Hideyuki Okano; Shinsuke Shibata; Hiroko Baba; Kanehiro Fujiyoshi; Akiko Hayashi; Keigo Hikishima; Koichi Honke; Tsunehiko Konomi; Masaya Nakamura
MRI characterization of paranodal junction failure and related spinal cord changes in mice.
PloS one 2012;7(12):e52904.
2012: Yoshiomi Kobayashi; Tsunehiko Konomi; Masaya Nakamura; Soraya Nishimura; Satoshi Nori; Yohei Okada; Kanehiro Fujiyoshi; Keigo Hikishima; Go Itakura; Hiroki Iwai; Yoshiaki Toyama; Osahiko Tsuji; Shinya Yamanaka; Akimasa Yasuda; Hideyuki Okano
Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity.
PloS one 2012;7(12):e52787.
2012: Sho Kanzaki; Masaya Nakamura; Kaoru Ogawa; Hirotaka James Okano; Shinsuke Shibata; Akimasa Yasuda; Masato Fujioka; Hideyuki Okano
Novel in vivo imaging analysis of an inner ear drug delivery system in mice: comparison of inner ear drug concentrations over time after transtympanic and systemic injections.
PloS one 2012;7(12):e48480.
2012: Hideyuki Okano
[Regeneration of the damaged CNS using human iPSCs-derived neural progenitor cells].
Rinshō shinkeigaku = Clinical neurology 2012;52(11):1147.
2012: Takuya Yagi; Wado Akamatsu; Daisuke Ito; Yoshihiro Nihei; Yohei Okada; Hideyuki Okano; Norihiro Suzuki
[Modeling familial Alzheimer's disease with induced pluripotent stem cells].
Rinshō shinkeigaku = Clinical neurology 2012;52(11):1134-6.
2012: Hideyuki Okano
Investigation of pathophysiology of Parkinson's disease using iPS cells technology.
Rinshō shinkeigaku = Clinical neurology 2012;52(11):899.
2012: Hiroko Shimada; Ikuo Tomioka; Michisuke Yuzaki; Shin-ichi Ota; Erika Sasaki; Hayao Ebise; Keiji Ibata; Kazuhisa Kohda; Takuji Maeda; Masaya Nakamura; Toshihiro Nomura; Yohei Okada; Hideyuki Okano
Efficient derivation of multipotent neural stem/progenitor cells from non-human primate embryonic stem cells.
PloS one 2012;7(11):e49469.
2012: Masahiro Omoto; Shinsuke Shibata; Kazuo Tsubota; Kenji Yoshida; Satoru Yoshida; Tetsuya Kawakita; Toru Kimura; Akiyoshi Kishino; Hideyuki Miyashita; Hideyuki Okano; Shigeto Shimmura
The semaphorin 3A inhibitor SM-345431 accelerates peripheral nerve regeneration and sensitivity in a murine corneal transplantation model.
PloS one 2012;7(11):e47716.
2012: Yoichi Imaizumi; Daisuke Ito; Tetsuro Kobayashi; Masato Koike; Arifumi Kosakai; Naoko Kuzumaki; Yoshikuni Mizuno; Noboru Mizushima; Hideki Mochizuki; Atsushi Nakanishi; Tomoko Nihira; Manabu Ohyama; Yohei Okada; Wado Akamatsu; Masayuki Amagai; Manabu Funayama; Nobutaka Hattori; Hideki Hayakawa; Kozo Hayashi; Akiyoshi Hirayama; Takako Hishiki; Shigeto Sato; Masanobu Shouji; Tomoyoshi Soga; Makoto Suematsu; Norihiro Suzuki; Masashi Takanashi; Yasuo Uchiyama; Takuya Yagi; Hideyuki Okano
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.
Molecular brain 2012;5():35.
2012: Jun Namiki; Yasushi Ishihama; Takeshi Masuda; Sayuri Suzuki; Hideyuki Okano
Nestin protein is phosphorylated in adult neural stem/progenitor cells and not endothelial progenitor cells.
Stem cells international 2012;2012():430138.
2012: Masanori Imamura; Yoshimi Kawamura; Zachary Yu-Ching Lin; Yumi Matsuzaki; Ryusuke Nakajima; Hirotaka James Okano; Hironobu Okuno; Erika Sasaki; Ikuo Tomioka; Wado Akamatsu; Hideyuki Okano
Derivation of induced pluripotent stem cells by retroviral gene transduction in mammalian species.
Methods in molecular biology (Clifton, N.J.) 2012;925():21-48.
2012: Takuya Yagi; Wado Akamatsu; Yasumichi Arai; Nobuyoshi Hirose; Fuyuki Ishikawa; Daisuke Ito; Arifumi Kosakai; Akira Nabetani; Yoshihiro Nihei; Yohei Okada; Hideyuki Okano; Norihiro Suzuki
Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research.
PloS one 2012;7(7):e41572.
2012: Toshihide Kurihara; Hideyuki Okano; Yoko Ozawa; Susumu Ishida; Kazuo Tsubota
Renin-Angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction.
International journal of inflammation 2012;2012():581695.
2012: Jun Muto; Yoshinori Nishimoto; Daisuke Ogawa; Yohei Okada; Takao Imai; Akio Iwanami; Takeshi Kawase; Yo Mabuchi; Yumi Matsuzaki; Paul S Mischel; Hideyuki Saya; Kazunari Yoshida; Hideyuki Okano
RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways.
PloS one 2012;7(3):e33431.
2012: Hironori Kawahara; Takao Imai; Hideyuki Okano
MicroRNAs in Neural Stem Cells and Neurogenesis.
Frontiers in neuroscience 2012;6():30.
2012: Hideyuki Okano
The first clinical trial in Tohoku University Hospital after the Great East Japan Earthquake: the heroic efforts of my friend, Professor Masashi Aoki.
The Keio journal of medicine 2012;61(1):3-9.
2011: Akimasa Yasuda; Kanehiro Fujiyoshi; Chikako Miyauchi Hara; Yoshiomi Kobayashi; Atsuhi Miyawaki; Masaya Nakamura; Satoshi Nori; Hirotaka James Okano; Shinsuke Shibata; Yuichiro Takahashi; Morito Takano; Yoshiaki Toyama; Osahiko Tsuji; Hideyuki Okano
Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord.
Stem cells (Dayton, Ohio) 2011;29(12):1983-94.
2011: Takuya Yagi; Shinya Yamanaka; Takahito Yoshizaki; Wado Akamatsu; Daisuke Ito; Yoshihiro Nihei; Yohei Okada; Hideyuki Okano; Norihiro Suzuki
Modeling familial Alzheimer's disease with induced pluripotent stem cells.
Human molecular genetics 2011;20(23):4530-9.
2011: Hiroshi Kanda; Tatsushi Igaki; Hideyuki Okano; Masayuki Miura
Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(47):18977-82.
2011: Francois Renault-Mihara; Ken Saito; Shinsuke Shibata; Hirobumi Tada; Yoshiaki Toyama; Akimasa Yasuda; Takeshi Ikegami; Akio Iwanami; Kozo Kaibuchi; Hiroyuki Katoh; Yo Mabuchi; Masayuki Matsushita; Masahiko Mukaino; Masaya Nakamura; Satoshi Nori; Seiji Okada; Hideyuki Okano
Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition.
EMBO molecular medicine 2011;3(11):682-96.
2011: Satoshi Nori; Yohei Okada; Kanehiro Fujiyoshi; Eiji Ikeda; Yoshiomi Kobayashi; Masato Koike; Masaya Nakamura; Yuichiro Takahashi; Yoshiaki Toyama; Osahiko Tsuji; Yasuo Uchiyama; Shinya Yamanaka; Akimasa Yasuda; Hideyuki Okano
Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(40):16825-30.
2011: Hideyuki Okano
Strategic approaches to regeneration of a damaged central nervous system.
Cornea 2011;30 Suppl 1():S15-8.
2011: Osahiko Tsuji; Kanehiro Fujiyoshi; Kyoko Miura; Suketaka Momoshima; Masaya Nakamura; Hideyuki Okano
Cell therapy for spinal cord injury by neural stem/progenitor cells derived from iPS/ES cells.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2011;8(4):668-76.
2011: Seiji Shiozawa; Yusuke Sotomaru; Hiroshi Suemizu; Ikuo Tomioka; Hirotaka James Okano; Akifumi Kanda; Kenji Kawai; Takuji Maeda; Yohei Okada; Erika Sasaki; Haruka Shinohara; Hideyuki Okano
Gene targeting and subsequent site-specific transgenesis at the β-actin (ACTB) locus in common marmoset embryonic stem cells.
Stem cells and development 2011;20(9):1587-99.
2011: Makoto Hosoya; Satoru Matsuda; Fumiko Nakagawa; Kaoru Ogawa; Hiroyuki Ohba; Hirotaka James Okano; Yumiko Saga; Shinsuke Shibata; Ken-ichiro Wakabayashi; Takahisa Watabe; Masato Fujioka; Hideyuki Okano
Expression and function of Sox21 during mouse cochlea development.
Neurochemical research 2011;36(7):1261-9.
2011: Yuko Doi; Naoaki Shinzawa; Shinya Fukumoto; Hideyuki Okano; Hirotaka Kanuka
Calcium signal regulates temperature-dependent transformation of sporozoites in malaria parasite development.
Experimental parasitology 2011;128(2):176-80.
2011: Yoshiaki Kubota; Keiyo Takubo; Masanori Hirashima; Narihito Nagoshi; Kazuo Kishi; Yuji Okuno; Ayako Nakamura-Ishizu; Keigo Sano; Masato Murakami; Masatsugu Ema; Yoshiki Omatsu; Satoru Takahashi; Takashi Nagasawa; Masabumi Shibuya; Hideyuki Okano; Toshio Suda
Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero.
The Journal of experimental medicine 2011;208(5):949-60.
2011: Hironori Kawahara; Yohei Okada; Takao Imai; Akio Iwanami; Paul S Mischel; Hideyuki Okano
Musashi1 cooperates in abnormal cell lineage protein 28 (Lin28)-mediated let-7 family microRNA biogenesis in early neural differentiation.
The Journal of biological chemistry 2011;286(18):16121-30.
2011: Narihito Nagoshi; Shinsuke Shibata; Makoto Hamanoue; Yo Mabuchi; Yumi Matsuzaki; Yoshiaki Toyama; Masaya Nakamura; Hideyuki Okano
Schwann cell plasticity after spinal cord injury shown by neural crest lineage tracing.
Glia 2011;59(5):771-84.
2011: Minako Orihara-Ono; Masako Toriya; Keiko Nakao; Hideyuki Okano
Downregulation of Notch mediates the seamless transition of individual Drosophila neuroepithelial progenitors into optic medullar neuroblasts during prolonged G1.
Developmental biology 2011;351(1):163-75.
2011: Yuichi Tamura; Keisuke Matsumura; Motoaki Sano; Hidenori Tabata; Kensuke Kimura; Masaki Ieda; Takahide Arai; Yohei Ohno; Hideaki Kanazawa; Shinsuke Yuasa; Ruri Kaneda; Shinji Makino; Kazunori Nakajima; Hideyuki Okano; Keiichi Fukuda
Neural crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(3):582-9.
2011: K Hikishima; M M Quallo; Y Komaki; Masakazu Yamada; K Kawai; Suketaka Momoshima; H J Okano; E Sasaki; Norikazu Tamaoki; R N Lemon; A Iriki; Hideyuki Okano
Population-averaged standard template brain atlas for the common marmoset (Callithrix jacchus).
NeuroImage 2011;54(4):2741-9.
2011: Kazuya Kitamura; Masashi Aoki; Kanehiro Fujiyoshi; Hiroshi Funakoshi; Keigo Hikishima; Toshikazu Nakamura; Tatsuji Nomura; Hideyuki Okano; Yoshiaki Toyama; Fumika Toyota; Junichi Yamane; Masaya Nakamura
Human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury.
PloS one 2011;6(11):e27706.
2011: Junichi Yamane; Masanori Sakaguchi; Kazunobu Sawamoto; Yoshiaki Toyama; Satoru Ishibashi; Yonehiro Kanemura; Toshihiko Kuroiwa; Hiroyuki Miyoshi; Hidehiro Mizusawa; Masaya Nakamura; Hideyuki Okano
Transplantation of human neural stem/progenitor cells overexpressing galectin-1 improves functional recovery from focal brain ischemia in the Mongolian gerbil.
Molecular brain 2011;4():35.
2011: Hiroyuki Katoh; Yumi Matsuzaki; Takeo Minematsu; Narihito Nagoshi; Masaya Nakamura; Momoka Sato; Etsuko Satoh; Shinsuke Shibata; Yoshiaki Toyama; Chihiro Akazawa; Kimiko Fukuda; Hideyuki Okano
The dual origin of the peripheral olfactory system: placode and neural crest.
Molecular brain 2011;4():34.
2011: Takehiko Takagi; Yoshiaki Toyama; Akimasa Yasuda; Ken Ishii; Narihito Nagoshi; Hideyuki Okano; Hirotaka J Okano; Harukazu Saito; Momoka Sato; Shinsuke Shibata; Masaya Nakamura
Schwann-spheres derived from injured peripheral nerves in adult mice--their in vitro characterization and therapeutic potential.
PloS one 2011;6(6):e21497.
2011: Masaya Nakamura; Yoshiaki Toyama; Osahiko Tsuji; Barbara S Bregman; Hideyuki Okano
Mimicking the neurotrophic factor profile of embryonic spinal cord controls the differentiation potential of spinal progenitors into neuronal cells.
PloS one 2011;6(6):e20717.
2011: Masanao Tabuse; Cécile Thirant; Kazunari Yoshida; Hérve Chneiweiss; Raita Fukaya; Yutaka Kawakami; Takeshi Kawase; Yumi Matsuzaki; Aya Misawa; Yohei Ohashi; Shigeki Ohta; Hideyuki Okano; Hideyuki Saya; Masahiro Toda
Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells.
Molecular cancer 2011;10():60.
2011: Satoshi Kawase; Yumi Matsuzaki; Chikako Miyauchi-Hara; Atsushi Miyawaki; Yoshinori Nishimoto; Shin-ichi Fukami; Takao Imai; Shigeyoshi Itohara; Kunio Yaguchi; Hideyuki Okano
Identification of a novel intronic enhancer responsible for the transcriptional regulation of musashi1 in neural stem/progenitor cells.
Molecular brain 2011;4():14.
2011: Kunimichi Niibe; Yoshimi Kawamura; Daisuke Araki; Satoru Morikawa; Kyoko Miura; Sadafumi Suzuki; Shigeto Shimmura; Takehiko Sunabori; Yo Mabuchi; Yasuo Nagai; Taneaki Nakagawa; Hideyuki Okano; Yumi Matsuzaki
Purified mesenchymal stem cells are an efficient source for iPS cell induction.
PloS one 2011;6(3):e17610.
2011: Yoichi Imaizumi; Masanori Sakaguchi; Tsuyoshi Morishita; Mamoru Ito; Françoise Poirier; Kazunobu Sawamoto; Hideyuki Okano
Galectin-1 is expressed in early-type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus.
Molecular brain 2011;4():7.
2011: Munehisa Shinozaki; Yuichiro Takahashi; Masahiko Mukaino; Nobuhito Saito; Yoshiaki Toyama; Hideyuki Okano; Masaya Nakamura
Novel concept of motor functional analysis for spinal cord injury in adult mice.
Journal of biomedicine & biotechnology 2011;2011():157458.
2011: Shigeki Ohta; Yoichi Imaizumi; Yohei Okada; Wado Akamatsu; Reiko Kuwahara; Manabu Ohyama; Masayuki Amagai; Yumi Matsuzaki; Shinya Yamanaka; Hideyuki Okano; Yutaka Kawakami
Generation of human melanocytes from induced pluripotent stem cells.
PloS one 2011;6(1):e16182.
2011: Tatsushi Igaki; Hiroshi Kanda; Hideyuki Okano; Tian Xu; Masayuki Miura
Eiger and wengen: the Drosophila orthologs of TNF/TNFR.
Advances in experimental medicine and biology 2011;691():45-50.
2011: Yoko Ozawa; Toshihide Kurihara; Kazuo Tsubota; Hideyuki Okano
Regulation of posttranscriptional modification as a possible therapeutic approach for retinal neuroprotection.
Journal of ophthalmology 2011;2011():506137.
2011: Shenzhi Xu; Hideyuki Okano; Naohide Tomita; Yoshito Ikada
Recovery Effects of a 180 mT Static Magnetic Field on Bone Mineral Density of Osteoporotic Lumbar Vertebrae in Ovariectomized Rats.
Evidence-based complementary and alternative medicine : eCAM 2011;2011():.
2010: Hideyuki Okano
Investigation of regeneration of damaged CNS and neurological diseases mechanisms using iPS cells.
Rinshō shinkeigaku = Clinical neurology 2010;50(11):887.
2010: Haruhisa Inoue; Hideyuki Okano
[Frontline in the research of regenerative medicine].
Rinshō shinkeigaku = Clinical neurology 2010;50(11):886.
2010: Yoshinori Nishimoto; Hideyuki Okano
New insight into cancer therapeutics: induction of differentiation by regulating the Musashi/Numb/Notch pathway.
Cell research 2010;20(10):1083-5.
2010: Takuya Sato; Takuya Shimazaki; Hayato Naka; Shin-Ichi Fukami; Yasushi Satoh; Hideyuki Okano; Irit Lax; Joseph Schlessinger; Noriko Gotoh
FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.
Stem cells (Dayton, Ohio) 2010;28(9):1661-73.
2010: Ken-ichiro Kuwako; Kyoko Kakumoto; Takao Imai; Mana Igarashi; Takao Hamakubo; Shin-ichi Sakakibara; Marc Tessier-Lavigne; Hirotaka James Okano; Hideyuki Okano
Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression.
Neuron 2010;67(3):407-21.
2010: Masahiko Mukaino; Masaya Nakamura; Osamu Yamada; Seiji Okada; Satoru Morikawa; Francois Renault-Mihara; Akio Iwanami; Takeshi Ikegami; Yoshiyuki Ohsugi; Osahiko Tsuji; Hiroyuki Katoh; Yumi Matsuzaki; Yoshiaki Toyama; Meigen Liu; Hideyuki Okano
Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation.
Experimental neurology 2010;224(2):403-14.
2010: Osahiko Tsuji; Kyoko Miura; Yohei Okada; Kanehiro Fujiyoshi; Masahiko Mukaino; Narihito Nagoshi; Kazuya Kitamura; Gentaro Kumagai; Makoto Nishino; Shuta Tomisato; Hisanobu Higashi; Toshihiro Nagai; Hiroyuki Katoh; Kazuhisa Kohda; Yumi Matsuzaki; Michisuke Yuzaki; Eiji Ikeda; Yoshiaki Toyama; Masaya Nakamura; Shinya Yamanaka; Hideyuki Okano
Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(28):12704-9.
2010: Tsutomu Nishimura; Hideyuki Okano; Harue Tada; Etsuko Nishimura; Kenji Sugimoto; Kaneo Mohri; Masanori Fukushima
Lizards respond to an extremely low-frequency electromagnetic field.
The Journal of experimental biology 2010;213(Pt 12):1985-90.
2010: Masanori Sakaguchi; Yoichi Imaizumi; Tetsuro Shingo; Hirobumi Tada; Ko Hayama; Osamu Yamada; Tsuyoshi Morishita; Toshihiko Kadoya; Noboru Uchiyama; Takuya Shimazaki; Atsushi Kuno; Françoise Poirier; Jun Hirabayashi; Kazunobu Sawamoto; Hideyuki Okano
Regulation of adult neural progenitor cells by Galectin-1/beta1 Integrin interaction.
Journal of neurochemistry 2010;113(6):1516-24.
2010: Junichi Yamane; Masaya Nakamura; Akio Iwanami; Masanori Sakaguchi; Hiroyuki Katoh; Masayuki Yamada; Suketaka Momoshima; S Miyao; Ken Ishii; Norikazu Tamaoki; Tatsuji Nomura; Hirotaka James Okano; Yonehiro Kanemura; Yoshiaki Toyama; Hideyuki Okano
Transplantation of galectin-1-expressing human neural stem cells into the injured spinal cord of adult common marmosets.
Journal of neuroscience research 2010;88(7):1394-405.
2010: Toshihide Kurihara; Yoshiaki Kubota; Yoko Ozawa; Keiyo Takubo; Kousuke Noda; M Celeste Simon; Randall S Johnson; Makoto Suematsu; Kazuo Tsubota; Susumu Ishida; Nobuhito Goda; Toshio Suda; Hideyuki Okano
von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina.
Development (Cambridge, England) 2010;137(9):1563-71.
2010: Hideyuki Shimizu; Atsuo Mori; Tatsuya Yamada; Akiko Ishikawa; Hideyuki Okano; Junzo Takeda; Ryohei Yozu
Regional spinal cord cooling using a countercurrent closed-lumen epidural catheter.
The Annals of thoracic surgery 2010;89(4):1312-3.
2010: Koichi Oki; Naoko Kaneko; Hiroaki Kanki; Takao Imai; Norihiro Suzuki; Kazunobu Sawamoto; Hideyuki Okano
Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia.
Neuroscience research 2010;66(4):390-5.
2010: Kenichiro Wakabayashi; Masato Fujioka; Sho Kanzaki; Hirotaka James Okano; Shinsuke Shibata; Daisuke Yamashita; Masatsugu Masuda; Masahiko Mihara; Yoshiyuki Ohsugi; Kaoru Ogawa; Hideyuki Okano
Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea.
Neuroscience research 2010;66(4):345-52.
2010: Seiji Ishii; Yohei Okada; Toshihiko Kadoya; Yumi Matsuzaki; Takuya Shimazaki; Hideyuki Okano
Stromal cell-secreted factors promote the survival of embryonic stem cell-derived early neural stem/progenitor cells via the activation of MAPK and PI3K-Akt pathways.
Journal of neuroscience research 2010;88(4):722-34.
2010: Hirobumi Tada; Hirotaka James Okano; Hiroshi Takagi; Shinsuke Shibata; Ikuko Yao; Masaki Matsumoto; Toru Saiga; Keiichi I Nakayama; Haruo Kashima; Takuya Takahashi; Mitsutoshi Setou; Hideyuki Okano
Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.
The Journal of biological chemistry 2010;285(6):3840-9.
2010: Osamu Tao; Takuya Shimazaki; Yohei Okada; Hayato Naka; Kazuhisa Kohda; Michisuke Yuzaki; Hidehiro Mizusawa; Hideyuki Okano
Efficient generation of mature cerebellar Purkinje cells from mouse embryonic stem cells.
Journal of neuroscience research 2010;88(2):234-47.
2010: Shinsuke Shibata; Akimasa Yasuda; Francois Renault-Mihara; Satoshi Suyama; Hiroyuki Katoh; Takayoshi Inoue; Yukiko U Inoue; Narihito Nagoshi; Momoka Sato; Masaya Nakamura; Chihiro Akazawa; Hideyuki Okano
Sox10-Venus mice: a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes.
Molecular brain 2010;3():31.
2010: Yuko Aihara; Yohei Hayashi; Mitsuhi Hirata; Nobutaka Ariki; Shinsuke Shibata; Narihito Nagoshi; Mio NAKANISHI; Kiyoshi Ohnuma; Masaki Warashina; Tatsuo Michiue; Hideho Uchiyama; Hideyuki Okano; Makoto Asashima; Miho Kusuda Furue
Induction of neural crest cells from mouse embryonic stem cells in a serum-free monolayer culture.
The International journal of developmental biology 2010;54(8-9):1287-94.
2010: Hirotaka Masuda; Yumi Matsuzaki; Emi Hiratsu; Masanori Ono; Takashi Nagashima; Takashi Kajitani; Toru Arase; Hideyuki Oda; Hiroshi Uchida; Hironori Asada; Mamoru Ito; Yasunori Yoshimura; Tetsuo Maruyama; Hideyuki Okano
Stem cell-like properties of the endometrial side population: implication in endometrial regeneration.
PloS one 2010;5(4):e10387.
2010: Hideyuki Okano
Neural stem cells and strategies for the regeneration of the central nervous system.
Proceedings of the Japan Academy. Series B, Physical and biological sciences 2010;86(4):438-50.
2010: Hiroaki Kanki; Marilia Kimie Shimabukuro; Atsushi Miyawaki; Hideyuki Okano
"Color Timer" mice: visualization of neuronal differentiation with fluorescent proteins.
Molecular brain 2010;3():5.
2009: Masae Yaguchi; Masanao Tabuse; Shigeki Ohta; Kozo Ohkusu-Tsukada; Tamaki Takeuchi; Junichi Yamane; Hiroyuki Katoh; Masaya Nakamura; Yumi Matsuzaki; Masayuki Yamada; Toshio Itoh; Tatsuji Nomura; Yoshiaki Toyama; Hideyuki Okano; Masahiro Toda
Transplantation of dendritic cells promotes functional recovery from spinal cord injury in common marmoset.
Neuroscience research 2009;65(4):384-92.
2009: Junko Murata; Toshiyuki Ohtsuka; Akinori Tokunaga; Suetaka Nishiike; Hidenori Inohara; Hideyuki Okano; Ryoichiro Kageyama
Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1.
Journal of neuroscience research 2009;87(16):3521-34.
2009: Hideyuki Okano
[Regeneration of the central nervous system using iPS cell-technologies].
Rinshō shinkeigaku = Clinical neurology 2009;49(11):825-6.
2009: Hideyuki Okano
Strategies toward CNS-regeneration using induced pluripotent stem cells.
Genome informatics. International Conference on Genome Informatics 2009;23(1):217-20.
2009: Yutaka Mine; Takuro Hayashi; Motoyuki Yamada; Hideyuki Okano; Takeshi Kawase
Environmental cue-dependent dopaminergic neuronal differentiation and functional effect of grafted neuroepithelial stem cells in parkinsonian brain.
Neurosurgery 2009;65(4):741-53; discussion 753.
2009: Narihito Nagoshi; Shinsuke Shibata; Masaya Nakamura; Yumi Matsuzaki; Yoshiaki Toyama; Hideyuki Okano
Neural crest-derived stem cells display a wide variety of characteristics.
Journal of cellular biochemistry 2009;107(6):1046-52.
2009: Kyoko Miura; Yohei Okada; Takashi Aoi; Aki Okada; Kazutoshi Takahashi; Keisuke Okita; Masato Nakagawa; Michiyo Koyanagi; Koji Tanabe; Mari Ohnuki; Daisuke Ogawa; Eiji Ikeda; Hideyuki Okano; Shinya Yamanaka
Variation in the safety of induced pluripotent stem cell lines.
Nature biotechnology 2009;27(8):743-5.
2009: Kimiko Tatsumi; Shoji Tsuji; Hideki Miwa; Toshinori Morisaku; Mutsuo Nuriya; Minako Orihara; Kazunari Kaneko; Hideyuki Okano; Masato Yasui
Drosophila big brain does not act as a water channel, but mediates cell adhesion.
FEBS letters 2009;583(12):2077-82.
2009: Hideyuki Okano; Sally Temple
Cell types to order: temporal specification of CNS stem cells.
Current opinion in neurobiology 2009;19(2):112-9.
2009: Satoru Morikawa; Yo Mabuchi; Kunimichi Niibe; Sadafumi Suzuki; Narihito Nagoshi; Takehiko Sunabori; Shigeto Shimmura; Yasuo Nagai; Taneaki Nakagawa; Hideyuki Okano; Yumi Matsuzaki
Development of mesenchymal stem cells partially originate from the neural crest.
Biochemical and biophysical research communications 2009;379(4):1114-9.
2009: Wado Akamatsu; Brian DeVeale; Hideyuki Okano; Austin J Cooney; Derek van der Kooy
Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(7):2113-24.
2009: Daisuke Ogawa; Yohei Okada; Masaya Nakamura; Yonehiro Kanemura; Hirotaka James Okano; Yumi Matsuzaki; Takuya Shimazaki; Mamoru Ito; Eiji Ikeda; Takashi Tamiya; Seigo Nagao; Hideyuki Okano
Evaluation of human fetal neural stem/progenitor cells as a source for cell replacement therapy for neurological disorders: properties and tumorigenicity after long-term in vitro maintenance.
Journal of neuroscience research 2009;87(2):307-17.
2009: Gentaro Kumagai; Yohei Okada; Junichi Yamane; Narihito Nagoshi; Kazuya Kitamura; Masahiko Mukaino; Osahiko Tsuji; Kanehiro Fujiyoshi; Hiroyuki Katoh; Seiji Okada; Shinsuke Shibata; Yumi Matsuzaki; Satoshi Toh; Yoshiaki Toyama; Masaya Nakamura; Hideyuki Okano
Roles of ES cell-derived gliogenic neural stem/progenitor cells in functional recovery after spinal cord injury.
PloS one 2009;4(11):e7706.
2008: Masayuki Yamada; Suketaka Momoshima; Yoshitaka Masutani; Kanehiro Fujiyoshi; Osamu Abe; Masaya Nakamura; Shigeki Aoki; Norikazu Tamaoki; Hideyuki Okano
Diffusion-tensor neuronal fiber tractography and manganese-enhanced MR imaging of primate visual pathway in the common marmoset: preliminary results.
Radiology 2008;249(3):855-64.
2008: Yoko Ozawa; Keiko Nakao; Toshihide Kurihara; Takuya Shimazaki; Shigeto Shimmura; Susumu Ishida; Akihiko Yoshimura; Kazuo Tsubota; Hideyuki Okano
Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation.
The Journal of biological chemistry 2008;283(36):24561-70.
2008: Hayato Naka; Shiho Nakamura; Takuya Shimazaki; Hideyuki Okano
Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development.
Nature neuroscience 2008;11(9):1014-23.
2008: Satoru Miyagi; Shinji Masui; Hitoshi Niwa; Tetsuichiro Saito; Takuya Shimazaki; Hideyuki Okano; Masazumi Nishimoto; Masami Muramatsu; Atsushi Iwama; Akihiko Okuda
Consequence of the loss of Sox2 in the developing brain of the mouse.
FEBS letters 2008;582(18):2811-5.
2008: Toshihide Kurihara; Yoko Ozawa; Norihiro Nagai; Kei Shinoda; Kousuke Noda; Yutaka Imamura; Kazuo Tsubota; Hideyuki Okano; Yuichi Oike; Susumu Ishida
Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina.
Diabetes 2008;57(8):2191-8.
2008: Hideyuki Okano; Kazunobu Sawamoto
Neural stem cells: involvement in adult neurogenesis and CNS repair.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1500):2111-22.
2008: Hideyuki Okano; Toshio Yanagida; Atsushi Iriki
Introduction. Japan: its tradition and hot topics in biological sciences.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1500):2067-9.
2008: Hironori Kawahara; Takao Imai; Hiroaki Imataka; Masafumi Tsujimoto; Ken Matsumoto; Hideyuki Okano
Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP.
The Journal of cell biology 2008;181(4):639-53.
2008: Takehiko Sunabori; Akinori Tokunaga; Takeharu Nagai; Kazunobu Sawamoto; Masaru Okabe; Atsushi Miyawaki; Yumi Matsuzaki; Takaki Miyata; Hideyuki Okano
Cell-cycle-specific nestin expression coordinates with morphological changes in embryonic cortical neural progenitors.
Journal of cell science 2008;121(Pt 8):1204-12.
2008: Narihito Nagoshi; Shinsuke Shibata; Yoshiaki Kubota; Masaya Nakamura; Yasuo Nagai; Etsuko Satoh; Satoru Morikawa; Yohei Okada; Yo Mabuchi; Hiroyuki Katoh; Seiji Okada; Keiichi Fukuda; Toshio Suda; Yumi Matsuzaki; Yoshiaki Toyama; Hideyuki Okano
Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad.
Cell stem cell 2008;2(4):392-403.
2008: Shigeki Ohta; Yoko Ueda; Masae Yaguchi; Yumi Matsuzaki; Masaya Nakamura; Yoshiaki Toyama; Yoshikuni Tanioka; Norikazu Tamaoki; Tatsuji Nomura; Hideyuki Okano; Yutaka Kawakami; Masahiro Toda
Isolation and characterization of dendritic cells from common marmosets for preclinical cell therapy studies.
Immunology 2008;123(4):566-74.
2008: Hiroaki Murata; Shingo Tsuji; Masahiko Tsujii; Toru Nakamura; Hai Ying Fu; Hiroshi Eguchi; Kayoko Asahi; Hideyuki Okano; Sunao Kawano; Norio Hayashi
Helicobacter pylori infection induces candidate stem cell marker Musashi-1 in the human gastric epithelium.
Digestive diseases and sciences 2008;53(2):363-9.
2008: Francois Renault-Mihara; Seiji Okada; Shinsuke Shibata; Masaya Nakamura; Yoshiaki Toyama; Hideyuki Okano
Spinal cord injury: emerging beneficial role of reactive astrocytes' migration.
The international journal of biochemistry & cell biology 2008;40(9):1649-53.
2008: Dexuan Ma; Li Lu; Nadezhda B Boneva; Shogo Warashina; Desislav B Kaplamadzhiev; Yoshimi Mori; Masa-aki Nakaya; Mitsuru Kikuchi; Anton B Tonchev; Hideyuki Okano; Tetsumori Yamashima
Expression of free fatty acid receptor GPR40 in the neurogenic niche of adult monkey hippocampus.
Hippocampus 2008;18(3):326-33.
2007: Yujiro Hattori; Shigeki Ohta; Kenji Hamada; Hisafumi Yamada-Okabe; Yonehiro Kanemura; Yumi Matsuzaki; Hideyuki Okano; Yutaka Kawakami; Masahiro Toda
Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1.
Biochemical and biophysical research communications 2007;364(4):737-42.
2007: Takeshi Marumo; Keiichi Hishikawa; Yumi Matsuzaki; Naohiko Imai; Osamu Takase; Tatsuo Shimosawa; Hideyuki Okano; Toshiro Fujita
Angiotensin II type 1 receptor blockade prevents decrease in adult stem-like cells in kidney after ureteral obstruction.
European journal of pharmacology 2007;573(1-3):216-20.
2007: Akihiro Yoshitake; Atsuo Mori; Hideyuki Shimizu; Toshihiko Ueda; Nobuyuki Kabei; Takashi Hachiya; Hideyuki Okano; Ryohei Yozu
Use of an epidural cooling catheter with a closed countercurrent lumen to protect against ischemic spinal cord injury in pigs.
The Journal of thoracic and cardiovascular surgery 2007;134(5):1220-6.
2007: Jun Fujita; Mitsuharu Mori; Hiroshi Kawada; Yasuyo Ieda; Mitsuyo Tsuma; Yumi Matsuzaki; Haruko Kawaguchi; Takashi Yagi; Shinsuke Yuasa; Jin Endo; Tomomitsu Hotta; Satoshi Ogawa; Hideyuki Okano; Ryohei Yozu; Kiyoshi Ando; Keiichi Fukuda
Administration of granulocyte colony-stimulating factor after myocardial infarction enhances the recruitment of hematopoietic stem cell-derived myofibroblasts and contributes to cardiac repair.
Stem cells (Dayton, Ohio) 2007;25(11):2750-9.
2007: Kazuhide Adachi; Zaman Mirzadeh; Masanori Sakaguchi; Toru Yamashita; Tania Nikolcheva; Yukiko Gotoh; Gary Peltz; Leyi Gong; Takeshi Kawase; Arturo Alvarez-Buylla; Hideyuki Okano; Kazunobu Sawamoto
Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone.
Stem cells (Dayton, Ohio) 2007;25(11):2827-36.
2007: Kanehiro Fujiyoshi; Masayuki Yamada; Masaya Nakamura; Junichi Yamane; Hiroyuki Katoh; Kazuya Kitamura; Kenji Kawai; Seiji Okada; Suketaka Momoshima; Yoshiaki Toyama; Hideyuki Okano
In vivo tracing of neural tracts in the intact and injured spinal cord of marmosets by diffusion tensor tractography.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(44):11991-8.
2007: Satoru Ishibashi; Toshihiko Kuroiwa; Masanori Sakaguchi; Liyuan Sun; Toshihiko Kadoya; Hideyuki Okano; Hidehiro Mizusawa
Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke.
Experimental neurology 2007;207(2):302-13.
2007: Naohiko Imai; Keiichi Hishikawa; Takeshi Marumo; Junichi Hirahashi; Toshihiko Inowa; Yumi Matsuzaki; Hideyuki Okano; Tadaichi Kitamura; David J Salant; Toshiro Fujita
Inhibition of histone deacetylase activates side population cells in kidney and partially reverses chronic renal injury.
Stem cells (Dayton, Ohio) 2007;25(10):2469-75.
2007: Hideyuki Okano
Isolation and identification of putative stem/progenitor cells from human cycling endometrium.
The journal of obstetrics and gynaecology research 2007;33 Suppl 1():S56-7.
2007: Hideyuki Okano; Masanori Sakaguchi; Koichi Ohki; Norihiro Suzuki; Kazunobu Sawamoto
Regeneration of the central nervous system using endogenous repair mechanisms.
Journal of neurochemistry 2007;102(5):1459-65.
2007: Kazuya Kitamura; Akio Iwanami; Masaya Nakamura; Junichi Yamane; Kota Watanabe; Yoshinori Suzuki; Daisuke Miyazawa; Shinsuke Shibata; Hiroshi Funakoshi; Shinichi Miyatake; Robert S Coffin; Toshikazu Nakamura; Yoshiaki Toyama; Hideyuki Okano
Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury.
Journal of neuroscience research 2007;85(11):2332-42.
2007: Hideyuki Okano; Shinjiro Kaneko; Seiji Okada; Akio Iwanami; Masaya Nakamura; Yoshiaki Toyama
Regeneration-based therapies for spinal cord injuries.
Neurochemistry international 2007;51(2-4):68-73.
2007: Kanako Izumi-Nagai; Norihiro Nagai; Yoko Ozawa; Masahiko Mihara; Yoshiyuki Ohsugi; Toshihide Kurihara; Takashi Koto; Shingo Satofuka; Makoto Inoue; Kazuo Tsubota; Hideyuki Okano; Yuichi Oike; Susumu Ishida
Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization.
The American journal of pathology 2007;170(6):2149-58.
2007: Takatoshi Iijima; Hiroo Ogura; Kanako Takatsuki; Shigenori Kawahara; Kenichiro Wakabayashi; Daisuke Nakayama; Masato Fujioka; Yuki Kimura; Alan Bernstein; Hirotaka James Okano; Yutaka Kirino; Hideyuki Okano
Impaired motor functions in mice lacking the RNA-binding protein Hzf.
Neuroscience research 2007;58(2):183-9.
2007: Yoshika Hayakawa-Yano; Keigo Nishida; Shinichi Fukami; Yukiko Gotoh; Toshio Hirano; Toshiyuki Nakagawa; Takuya Shimazaki; Hideyuki Okano
Epidermal growth factor signaling mediated by grb2 associated binder1 is required for the spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord.
Stem cells (Dayton, Ohio) 2007;25(6):1410-22.
2007: Kenta Watanabe; Kenji Kondo; Naonobu Takeuchi; Hideyuki Okano; Tatsuya Yamasoba
Musashi-1 expression in postnatal mouse olfactory epithelium.
Neuroreport 2007;18(7):641-4.
2007: Masanori Sakaguchi; Y Imaizumi; Hideyuki Okano
Expression and function of galectin-1 in adult neural stem cells.
Cellular and molecular life sciences : CMLS 2007;64(10):1254-8.
2007: Yoko Koide; Satoru Morikawa; Yo Mabuchi; Yukari Muguruma; Emi Hiratsu; Kohji Hasegawa; Makoto Kobayashi; Kiyoshi Ando; Kentaro Kinjo; Hideyuki Okano; Yumi Matsuzaki
Two distinct stem cell lineages in murine bone marrow.
Stem cells (Dayton, Ohio) 2007;25(5):1213-21.
2007: Naoko Kato; Shigeto Shimmura; Tetsuya Kawakita; Hideyuki Miyashita; Yoko Ogawa; Satoru Yoshida; Kazunari Higa; Hideyuki Okano; Kazuo Tsubota
Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium.
Investigative ophthalmology & visual science 2007;48(4):1511-7.
2007: Yoko Ozawa; Keiko Nakao; Takuya Shimazaki; Shigeto Shimmura; Toshihide Kurihara; Susumu Ishida; Akihiko Yoshimura; Kazuo Tsubota; Hideyuki Okano
SOCS3 is required to temporally fine-tune photoreceptor cell differentiation.
Developmental biology 2007;303(2):591-600.
2007: Hirotaka Masuda; Tetsuo Maruyama; Emi Hiratsu; Junichi Yamane; Akio Iwanami; Takashi Nagashima; Masanori Ono; Hiroyuki Miyoshi; Hirotaka James Okano; Mamoru Ito; Norikazu Tamaoki; Tatsuji Nomura; Hideyuki Okano; Yumi Matsuzaki; Yasunori Yoshimura
Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/gamma c(null) immunodeficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1925-30.
2007: Kota Watanabe; Masaya Nakamura; Hideyuki Okano; Yoshiaki Toyama
Establishment of three-dimensional culture of neural stem/progenitor cells in collagen Type-1 Gel.
Restorative neurology and neuroscience 2007;25(2):109-17.
2007: Ryuichi Kanai; Hideyuki Tomita; Yuichi Hirose; Shigeo Ohba; Steven Goldman; Hideyuki Okano; Takeshi Kawase; Takahito Yazaki
Augmented therapeutic efficacy of an oncolytic herpes simplex virus type 1 mutant expressing ICP34.5 under the transcriptional control of musashi1 promoter in the treatment of malignant glioma.
Human gene therapy 2007;18(1):63-73.
2006: Toshihide Kurihara; Yoko Ozawa; Kei Shinoda; Norihiro Nagai; Makoto Inoue; Yuichi Oike; Kazuo Tsubota; Susumu Ishida; Hideyuki Okano
Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation.
Investigative ophthalmology & visual science 2006;47(12):5545-52.
2006: Shinjiro Kaneko; Akio Iwanami; Masaya Nakamura; Akiyoshi Kishino; Kaoru Kikuchi; Shinsuke Shibata; Hirotaka J Okano; Takeshi Ikegami; Ayako Moriya; Osamu Konishi; Chikao Nakayama; Kazuo Kumagai; Toru Kimura; Yasufumi Sato; Yoshio Goshima; Masahiko Taniguchi; Mamoru Ito; Zhigang He; Yoshiaki Toyama; Hideyuki Okano
A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord.
Nature medicine 2006;12(12):1380-9.
2006: Ryuichi Kanai; Keisuke Eguchi; Miwa Takahashi; Steven Goldman; Hideyuki Okano; Takeshi Kawase; Takahito Yazaki
Enhanced therapeutic efficacy of oncolytic herpes vector G207 against human non-small cell lung cancer--expression of an RNA-binding protein, Musashi1, as a marker for the tailored gene therapy.
The journal of gene medicine 2006;8(11):1329-40.
2006: Tsutomu Sasaki; Kazuo Kitagawa; Yoshiki Yagita; Shiro Sugiura; Emi Omura-Matsuoka; Shigeru Tanaka; Kohji Matsushita; Hideyuki Okano; Yoshihide Tsujimoto; Masatsugu Hori
Bcl2 enhances survival of newborn neurons in the normal and ischemic hippocampus.
Journal of neuroscience research 2006;84(6):1187-96.
2006: Naoko Kaneko; Hideyuki Okano; Kazunobu Sawamoto
Role of the cholinergic system in regulating survival of newborn neurons in the adult mouse dentate gyrus and olfactory bulb.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(10):1145-59.
2006: Mikiko Ninomiya; Toru Yamashita; Nobuo Araki; Hideyuki Okano; Kazunobu Sawamoto
Enhanced neurogenesis in the ischemic striatum following EGF-induced expansion of transit-amplifying cells in the subventricular zone.
Neuroscience letters 2006;403(1-2):63-7.
2006: Junko Murata; Akinori Tokunaga; Hideyuki Okano; Takeshi Kubo
Mapping of notch activation during cochlear development in mice: implications for determination of prosensory domain and cell fate diversification.
The Journal of comparative neurology 2006;497(3):502-18.
2006: Yukinobu Arata; Hiroko Kouike; Yanping Zhang; Michael A Herman; Hideyuki Okano; Hitoshi Sawa
Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans.
Developmental cell 2006;11(1):105-15.
2006: Seiji Okada; Masaya Nakamura; Hiroyuki Katoh; Tamaki Miyao; Takuya Shimazaki; Ken Ishii; Junichi Yamane; Akihiko Yoshimura; Yukihide Iwamoto; Yoshiaki Toyama; Hideyuki Okano
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.
Nature medicine 2006;12(7):829-34.
2006: Toru Yamashita; Mikiko Ninomiya; Pilar Hernández-Acosta; José Manuel García-Verdugo; Takehiko Sunabori; Masanori Sakaguchi; Kazuhide Adachi; Takuro Kojima; Yuki Hirota; Takeshi Kawase; Nobuo Araki; Koji Abe; Hideyuki Okano; Kazunobu Sawamoto
Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(24):6627-36.
2006: Satoru Miyagi; Masazumi Nishimoto; Tetsuichiro Saito; Mikiko Ninomiya; Kazunobu Sawamoto; Hideyuki Okano; Masami Muramatsu; Hideyuki Oguro; Atsushi Iwama; Akihiko Okuda
The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon.
The Journal of biological chemistry 2006;281(19):13374-81.
2006: Masanori Sakaguchi; Tetsuro Shingo; Takuya Shimazaki; Hirotaka James Okano; Mieko Shiwa; Satoru Ishibashi; Hideyuki Oguro; Mikiko Ninomiya; Toshihiko Kadoya; Hidenori Horie; Akira Shibuya; Hidehiro Mizusawa; Françoise Poirier; Hiromitsu Nakauchi; Kazunobu Sawamoto; Hideyuki Okano
A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):7112-7.
2006: Masato Fujioka; Sho Kanzaki; Hirotaka James Okano; Masatsugu Masuda; Kaoru Ogawa; Hideyuki Okano
Proinflammatory cytokines expression in noise-induced damaged cochlea.
Journal of neuroscience research 2006;83(4):575-83.
2006: Hiroshi Kawada; Shunya Takizawa; Tomomi Takanashi; Yuko Morita; Jun Fujita; Keiichi Fukuda; Shigeharu Takagi; Hideyuki Okano; Kiyoshi Ando; Tomomitsu Hotta
Administration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow-derived neuronal cells.
Circulation 2006;113(5):701-10.
2006: Kazunobu Sawamoto; Hynek Wichterle; Oscar Gonzalez-Perez; Jeremy A Cholfin; Masayuki Yamada; Nathalie Spassky; Noel S Murcia; Jose Manuel Garcia-Verdugo; Oscar Marin; John L R Rubenstein; Marc Tessier-Lavigne; Hideyuki Okano; Arturo Alvarez-Buylla
New neurons follow the flow of cerebrospinal fluid in the adult brain.
Science (New York, N.Y.) 2006;311(5761):629-32.
2006: Hiroshi Nagata; Yasutada Akiba; Hidekazu Suzuki; Hideyuki Okano; Toshifumi Hibi
Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution.
FEBS letters 2006;580(1):27-33.
2006: Hideyuki Okano
Adult neural stem cells and central nervous system repair.
Ernst Schering Research Foundation workshop 2006;(60):215-28.
2006: Masako Toriya; Akinori Tokunaga; Kazunobu Sawamoto; Keiko Nakao; Hideyuki Okano
Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain.
Developmental neuroscience 2006;28(1-2):142-55.
2006: Arifumi Matsumoto; Yohei Okada; Masanori Nakamichi; Masaya Nakamura; Yoshiaki Toyama; Gen Sobue; Makiko Nagai; Masashi Aoki; Yasuto Itoyama; Hideyuki Okano
Disease progression of human SOD1 (G93A) transgenic ALS model rats.
Journal of neuroscience research 2006;83(1):119-33.
2006: Ryuichi Kanai; Hideyuki Tomita; A Shinoda; M Takahashi; Steven Goldman; Hideyuki Okano; Takeshi Kawase; Takahito Yazaki
Enhanced therapeutic efficacy of G207 for the treatment of glioma through Musashi1 promoter retargeting of gamma34.5-mediated virulence.
Gene therapy 2006;13(2):106-16.
2005: Motoki Inaji; Takashi Okauchi; Kiyoshi Ando; Jun Maeda; Yuji Nagai; Takahito Yoshizaki; Hideyuki Okano; Tadashi Nariai; Kikuo Ohno; Shigeru Obayashi; Makoto Higuchi; Tetsuya Suhara
Correlation between quantitative imaging and behavior in unilaterally 6-OHDA-lesioned rats.
Brain research 2005;1064(1-2):136-45.
2005: Takeshi Ikegami; Masaya Nakamura; Junichi Yamane; Hiroyuki Katoh; Seiji Okada; Akio Iwanami; Kota Watanabe; Ken Ishii; Fumikazu Kato; Hiroshi Fujita; Toyomi Takahashi; Hirotaka James Okano; Yoshiaki Toyama; Hideyuki Okano
Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injury.
The European journal of neuroscience 2005;22(12):3036-46.
2005: Hirotaka Kanuka; Tetsuo Hiratou; Tatsushi Igaki; Hiroshi Kanda; Erina Kuranaga; Kazunobu Sawamoto; Toshiro Aigaki; Hideyuki Okano; Masayuki Miura
Gain-of-function screen identifies a role of the Sec61alpha translocon in Drosophila postmitotic neurotoxicity.
Biochimica et biophysica acta 2005;1726(3):225-37.
2005: Takatoshi Iijima; Takao Imai; Yuki Kimura; Alan Bernstein; Hirotaka James Okano; Michisuke Yuzaki; Hideyuki Okano
Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17190-5.
2005: Hirotaka Kanuka; Erina Kuranaga; Kiwamu Takemoto; Tetsuo Hiratou; Hideyuki Okano; Masayuki Miura
Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development.
The EMBO journal 2005;24(21):3793-806.
2005: Masaya Nakamura; Yoshiaki Toyama; Hideyuki Okano
[Transplantation of neural stem cells for spinal cord injury].
Rinshō shinkeigaku = Clinical neurology 2005;45(11):874-6.
2005: Atsuo Mori; Toshihiko Ueda; Takashi Hachiya; Nobuyuki Kabei; Hideyuki Okano; Ryohei Yozu; Tatsuumi Sasaki
An epidural cooling catheter protects the spinal cord against ischemic injury in pigs.
The Annals of thoracic surgery 2005;80(5):1829-33.
2005: S Yamamoto; I Yoshino; T Shimazaki; M Murohashi; Robert Hevner; Irit Lax; Hideyuki Okano; Masabumi Shibuya; Joseph Schlessinger; Noriko Gotoh
Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15983-8.
2005: Hideyuki Okano; Seiji Okada; Masaya Nakamura; Yoshiaki Toyama
Neural stem cells and regeneration of injured spinal cord.
Kidney international 2005;68(5):1927-31.
2005: Takahiro Sasaki; Satoshi Iwata; Hirotaka James Okano; Yasuyo Urasaki; Junichi Hamada; Hirotoshi Tanaka; Nam H Dang; Hideyuki Okano; Chikao Morimoto
Nedd9 protein, a Cas-L homologue, is upregulated after transient global ischemia in rats: possible involvement of Nedd9 in the differentiation of neurons after ischemia.
Stroke; a journal of cerebral circulation 2005;36(11):2457-62.
2005: Seiji Okada; Ken Ishii; Junichi Yamane; Akio Iwanami; Takeshi Ikegami; Hiroyuki Katoh; Yukihide Iwamoto; Masaya Nakamura; Hiroyuki Miyoshi; Hirotaka James Okano; Christopher H Contag; Yoshiaki Toyama; Hideyuki Okano
In vivo imaging of engrafted neural stem cells: its application in evaluating the optimal timing of transplantation for spinal cord injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(13):1839-41.
2005: Rieko Asai; Hideyuki Okano; Sadao Yasugi
Correlation between Musashi-1 and c-hairy-1 expression and cell proliferation activity in the developing intestine and stomach of both chicken and mouse.
Development, growth & differentiation 2005;47(8):501-10.
2005: Jun Kohyama; Akinori Tokunaga; Yuko Fujita; Hiroyuki Miyoshi; Takeharu Nagai; Atsushi Miyawaki; Keiko Nakao; Yumi Matsuzaki; Hideyuki Okano
Visualization of spatiotemporal activation of Notch signaling: live monitoring and significance in neural development.
Developmental biology 2005;286(1):311-25.
2005: Yuichi Tomita; Keisuke Matsumura; Yoshio Wakamatsu; Yumi Matsuzaki; Isao Shibuya; Haruko Kawaguchi; Masaki Ieda; Sachiko Kanakubo; Takuya Shimazaki; Satoshi Ogawa; Noriko Osumi; Hideyuki Okano; Keiichi Fukuda
Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart.
The Journal of cell biology 2005;170(7):1135-46.
2005: Tsuyoshi Suzuki; Shuichi Izumoto; Kouichi Wada; Yasunori Fujimoto; Motohiko Maruno; Mami Yamasaki; Yonehiro Kanemura; Takuya Shimazaki; Hideyuki Okano; Toshiki Yoshimine
Inhibition of glioma cell proliferation by neural stem cell factor.
Journal of neuro-oncology 2005;74(3):233-9.
2005: Mutsuhiro Tamura; Masaya Nakamura; Yuto Ogawa; Yoshiaki Toyama; Masayuki Miura; Hideyuki Okano
Targeted expression of anti-apoptotic protein p35 in oligodendrocytes reduces delayed demyelination and functional impairment after spinal cord injury.
Glia 2005;51(4):312-21.
2005: Makoto Sahara; Masataka Sata; Yumi Matsuzaki; Kimie Tanaka; Toshihiro Morita; Yasunobu Hirata; Hideyuki Okano; Ryozo Nagai
Comparison of various bone marrow fractions in the ability to participate in vascular remodeling after mechanical injury.
Stem cells (Dayton, Ohio) 2005;23(7):874-8.
2005: Toru Yamashita; Kazunobu Sawamoto; Shigeaki Suzuki; Norihiro Suzuki; Kazuhide Adachi; Takeshi Kawase; Masahiko Mihara; Yoshiyuki Ohsugi; Koji Abe; Hideyuki Okano
Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons.
Journal of neurochemistry 2005;94(2):459-68.
2005: Koichi Uchida; Toshihiko Momiyama; Hideyuki Okano; Michisuke Yuzaki; Amane Koizumi; Yutaka Mine; Takeshi Kawase
Potential functional neural repair with grafted neural stem cells of early embryonic neuroepithelial origin.
Neuroscience research 2005;52(3):276-86.
2005: Keiichi Hishikawa; Takeshi Marumo; Shigeki Miura; Asato Nakanishi; Yumi Matsuzaki; Katsunori Shibata; Tomoko Ichiyanagi; Hiroko Kohike; Takuya Komori; Ichiro Takahashi; Osamu Takase; Naohiko Imai; Masahiro Yoshikawa; Toshihiko Inowa; Matsuhiko Hayashi; Toshio Nakaki; Hiromitsu Nakauchi; Hideyuki Okano; Toshiro Fujita
Musculin/MyoR is expressed in kidney side population cells and can regulate their function.
The Journal of cell biology 2005;169(6):921-8.
2005: Hideyuki Okano; Hironori Kawahara; Masako Toriya; Keio Nakao; Shinsuke Shibata; Takao Imai
Function of RNA-binding protein Musashi-1 in stem cells.
Experimental cell research 2005;306(2):349-56.
2005: Masaya Nakamura; Seiji Okada; Yoshiaki Toyama; Hideyuki Okano
Role of IL-6 in spinal cord injury in a mouse model.
Clinical reviews in allergy & immunology 2005;28(3):197-204.
2005: Yoshimasa Matsuda; Yoshio Wakamatsu; Jun Kohyama; Hideyuki Okano; Kimiko Fukuda; Sadao Yasugi
Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development.
Development (Cambridge, England) 2005;132(12):2783-93.
2005: Shigeaki Suzuki; Toru Yamashita; Kortaro Tanaka; Hidenori Hattori; Kazunobu Sawamoto; Hideyuki Okano; Norihiro Suzuki
Activation of cytokine signaling through leukemia inhibitory factor receptor (LIFR)/gp130 attenuates ischemic brain injury in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(6):685-93.
2005: Akio Iwanami; Junichi Yamane; Hiroyuki Katoh; Masaya Nakamura; Suketaka Momoshima; H Ishii; Y Tanioka; Norikazu Tamaoki; Tatsuji Nomura; Yoshiaki Toyama; Hideyuki Okano
Establishment of graded spinal cord injury model in a nonhuman primate: the common marmoset.
Journal of neuroscience research 2005;80(2):172-81.
2005: Akio Iwanami; Shinjiro Kaneko; Masaya Nakamura; Yonehiro Kanemura; H Mori; S Kobayashi; M Yamasaki; Suketaka Momoshima; H Ishii; K Ando; Y Tanioka; Norikazu Tamaoki; Tatsuji Nomura; Yoshiaki Toyama; Hideyuki Okano
Transplantation of human neural stem cells for spinal cord injury in primates.
Journal of neuroscience research 2005;80(2):182-90.
2005: Akinori Yoda; Hiroko Kouike; Hideyuki Okano; Hitoshi Sawa
Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans.
Development (Cambridge, England) 2005;132(8):1885-93.
2005: Masato Yano; Hirotaka J Okano; Hideyuki Okano
Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation.
The Journal of biological chemistry 2005;280(13):12690-9.
2005: Wado Akamatsu; Hiroaki Fujihara; Takayuki Mitsuhashi; Masato Yano; Shinsuke Shibata; Yoshika Hayakawa; Hirotaka James Okano; Shuhei Sakakibara; Hiroshi Takano; Toshiya Takano; Takao Takahashi; Tetsuo Noda; Hideyuki Okano
The RNA-binding protein HuD regulates neuronal cell identity and maturation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4625-30.
2005: Keiichi Hishikawa; Takeshi Marumo; Shigeki Miura; Asato Nakanishi; Yumi Matsuzaki; Katsunori Shibata; Hiroko Kohike; Takuya Komori; Matsuhiko Hayashi; Toshio Nakaki; Hiromitsu Nakauchi; Hideyuki Okano; Toshiro Fujita
Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16.
Biochemical and biophysical research communications 2005;328(1):288-91.
2005: Yuki Hirota; Kazunobu Sawamoto; Kuniaki Takahashi; Ryu Ueda; Hideyuki Okano
The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster.
Development genes and evolution 2005;215(2):90-6.
2005: Motoki Inaji; Takahito Yoshizaki; Takashi Okauchi; Jun Maeda; Yuji Nagai; Tadashi Nariai; Kikuo Ohno; Kiyoshi Ando; Hideyuki Okano; Shigeru Obayashi; Tetsuya Suhara
In vivo PET measurements with [11C]PE2I to evaluate fetal mesencephalic transplantations to unilateral 6-OHDA-lesioned rats.
Cell transplantation 2005;14(9):655-63.
2004: Hiroshi Kawada; Jun Fujita; Kentaro Kinjo; Yumi Matsuzaki; Mitsuyo Tsuma; Hiroko Miyatake; Yukari Muguruma; Kosuke Tsuboi; Yuji Itabashi; Yasuo Ikeda; Satoshi Ogawa; Hideyuki Okano; Tomomitsu Hotta; Kiyoshi Ando; Keiichi Fukuda
Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction.
Blood 2004;104(12):3581-7.
2004: Yohei Okada; Takuya Shimazaki; Gen Sobue; Hideyuki Okano
Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells.
Developmental biology 2004;275(1):124-42.
2004: Satoru Ishibashi; Masanori Sakaguchi; Toshihiko Kuroiwa; Mami Yamasaki; Yonehiro Kanemura; Ichinose Shizuko; Takuya Shimazaki; Masafumi Onodera; Hideyuki Okano; Hidehiro Mizusawa
Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils.
Journal of neuroscience research 2004;78(2):215-23.
2004: Koichi Uchida; Makio Mukai; Hideyuki Okano; Takeshi Kawase
Possible oncogenicity of subventricular zone neural stem cells: case report.
Neurosurgery 2004;55(4):977-8.
2004: Akinori Tokunaga; Jun Kohyama; Tetsu Yoshida; Keiko Nakao; Kazunobu Sawamoto; Hideyuki Okano
Mapping spatio-temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain.
Journal of neurochemistry 2004;90(1):142-54.
2004: Takahito Yoshizaki; Motoki Inaji; Hiroko Kouike; Takuya Shimazaki; Kazunobu Sawamoto; Kiyoshi Ando; Isao Date; Kazuto Kobayashi; Tetsuya Suhara; Yasuo Uchiyama; Hideyuki Okano
Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells.
Neuroscience letters 2004;363(1):33-7.
2004: Yoko Ozawa; Keiko Nakao; Takuya Shimazaki; Junji Takeda; Shizuo Akira; Katsuhiko Ishihara; Toshio Hirano; Yoshihisa Oguchi; Hideyuki Okano
Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina.
Molecular and cellular neurosciences 2004;26(2):258-70.
2004: Yuji Mikami; Hideyuki Okano; Masanori Sakaguchi; Masaya Nakamura; Takuya Shimazaki; Hirotaka James Okano; Yutaka Kawakami; Yoshiaki Toyama; Masahiro Toda
Implantation of dendritic cells in injured adult spinal cord results in activation of endogenous neural stem/progenitor cells leading to de novo neurogenesis and functional recovery.
Journal of neuroscience research 2004;76(4):453-65.
2004: Seiji Okada; Masaya Nakamura; Y Mikami; Takuya Shimazaki; Masahiko Mihara; Yoshiyuki Ohsugi; Yukihide Iwamoto; K Yoshizaki; T Kishimoto; Yoshiaki Toyama; Hideyuki Okano
Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury.
Journal of neuroscience research 2004;76(2):265-76.
2004: Hiroyuki Ohba; Tatsuyuki Chiyoda; Emmy Endo; Masato Yano; Yoshika Hayakawa; Masanori Sakaguchi; Robert B Darnell; Hirotaka J Okano; Hideyuki Okano
Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1.
Neuroscience letters 2004;358(3):157-60.
2004: Kota Watanabe; Masaya Nakamura; Akio Iwanami; Yuko Fujita; Yonehiro Kanemura; Yoshiaki Toyama; Hideyuki Okano
Comparison between fetal spinal-cord- and forebrain-derived neural stem/progenitor cells as a source of transplantation for spinal cord injury.
Developmental neuroscience 2004;26(2-4):275-87.
2004: Masaki Ieda; Keiichi Fukuda; Yasuyo Hisaka; Kensuke Kimura; Haruko Kawaguchi; Jun Fujita; Kouji Shimoda; Eiko Takeshita; Hideyuki Okano; Yukiko Kurihara; Hiroki Kurihara; Junji Ishida; Akiyoshi Fukamizu; Howard Federoff; Satoshi Ogawa
Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression.
The Journal of clinical investigation 2004;113(6):876-84.
2004: Junko Murata; Ayako Murayama; Arata Horii; Katsumi Doi; Tamotsu Harada; Hideyuki Okano; Takeshi Kubo
Expression of Musashi1, a neural RNA-binding protein, in the cochlea of young adult mice.
Neuroscience letters 2004;354(3):201-4.
2004: Yumi Matsuzaki; Kentaro Kinjo; Richard C Mulligan; Hideyuki Okano
Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells.
Immunity 2004;20(1):87-93.
2003: Hideyuki Okano; Takahito Yoshizaki; Seiji Okada
[Regeneration of central nervous system: its concept and strategy].
Rinshō shinkeigaku = Clinical neurology 2003;43(11):824-6.
2003: Hirotaka Kanuka; Erina Kuranaga; Tetsuo Hiratou; Tatsushi Igaki; Bryce Nelson; Hideyuki Okano; Masayuki Miura
Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11723-8.
2003: Shin Hisahara; Hideyuki Okano; Masayuki Miura
Caspase-mediated oligodendrocyte cell death in the pathogenesis of autoimmune demyelination.
Neuroscience research 2003;46(4):387-97.
2003: Koichi Uchida; Hideyuki Okano; Takuro Hayashi; Yutaka Mine; Yoshikuni Tanioka; Tatsuji Nomura; Takeshi Kawase
Grafted swine neuroepithelial stem cells can form myelinated axons and both efferent and afferent synapses with xenogeneic rat neurons.
Journal of neuroscience research 2003;72(6):661-9.
2003: Hideyuki Okano; Yuto Ogawa; Masaya Nakamura; Shinjiro Kaneko; Akio Iwanami; Yoshiaki Toyama
Transplantation of neural stem cells into the spinal cord after injury.
Seminars in cell & developmental biology 2003;14(3):191-8.
2003: Hideyuki Okano
Making and repairing the mammalian brain: Introduction.
Seminars in cell & developmental biology 2003;14(3):159.
2003: Yoshihiro Yuasa; Masataka Okabe; Shingo Yoshikawa; Katsuhiko Tabuchi; Wencheng Xiong; Yasushi Hiromi; Hideyuki Okano
Drosophila homeodomain protein REPO controls glial differentiation by cooperating with ETS and BTB transcription factors.
Development (Cambridge, England) 2003;130(11):2419-28.
2003: Tsutomu Sasaki; Kazuo Kitagawa; Shiro Sugiura; Emi Omura-Matsuoka; Shigeru Tanaka; Yoshiki Yagita; Hideyuki Okano; Masayasu Matsumoto; Masatsugu Hori
Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia.
Journal of neuroscience research 2003;72(4):461-71.
2003: Seiji Okada; Hideyuki Okano
[Regulatory mechanisms of neural stem cell and strategies for therapy].
Nihon rinsho. Japanese journal of clinical medicine 2003;61(3):449-56.
2002: Yuki Hirota; Kazunobu Sawamoto; Hideyuki Okano
tincar encodes a novel transmembrane protein expressed in the Tinman-expressing cardioblasts of Drosophila.
Mechanisms of development 2002;119 Suppl 1():S279-83.
2002: Yuki Hirota; Kazunobu Sawamoto; Hideyuki Okano
tincar encodes a novel transmembrane protein expressed in the Tinman-expressing cardioblasts of Drosophila.
Gene expression patterns : GEP 2002;2(3-4):323-7.
2002: Hideyuki Okano; Takahito Yoshizaki; Takuya Shimazaki; Kazunobu Sawamoto
Isolation and transplantation of dopaminergic neurons and neural stem cells.
Parkinsonism & related disorders 2002;9(1):23-8.
2002: Y Ogawa; Kazunobu Sawamoto; T Miyata; S Miyao; Masahiko Watanabe; Masaya Nakamura; B S Bregman; M Koike; Y Uchiyama; Yoshiaki Toyama; Hideyuki Okano
Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats.
Journal of neuroscience research 2002;69(6):925-33.
2002: Ayako Murayama; Yumi Matsuzaki; Ayano Kawaguchi; Takuya Shimazaki; Hideyuki Okano
Flow cytometric analysis of neural stem cells in the developing and adult mouse brain.
Journal of neuroscience research 2002;69(6):837-47.
2002: Yoshiki Yagita; Kazuo Kitagawa; Tsutomu Sasaki; Takaki Miyata; Hideyuki Okano; Masatsugu Hori; Masayasu Matsumoto
Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia.
Journal of neuroscience research 2002;69(6):750-6.
2002: Hideyuki Okano
Stem cell biology of the central nervous system.
Journal of neuroscience research 2002;69(6):698-707.
2002: Hideyuki Okano
Neural stem cells: progression of basic research and perspective for clinical application.
The Keio journal of medicine 2002;51(3):115-28.
2002: Erina Kuranaga; Hirotaka Kanuka; Tatsushi Igaki; Kazunobu Sawamoto; Hidenori Ichijo; Hideyuki Okano; Masayuki Miura
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.
Nature cell biology 2002;4(9):705-10.
2002: Mamoru Shibata; Takemori Yamawaki; Takahiro Sasaki; Hidenori Hattori; Junichi Hamada; Yasuo Fukuuchi; Hideyuki Okano; Masayuki Miura
Upregulation of Akt phosphorylation at the early stage of middle cerebral artery occlusion in mice.
Brain research 2002;942(1-2):1-10.
2002: Hideyuki Okano; Takao Imai; Masataka Okabe
Musashi: a translational regulator of cell fate.
Journal of cell science 2002;115(Pt 7):1355-9.
2002: Kenichirou Takasawa; Kazuo Kitagawa; Yoshiki Yagita; Tsutomu Sasaki; Shigeru Tanaka; Kohji Matsushita; Toshiho Ohstuki; Takaki Miyata; Hideyuki Okano; Masatsugu Hori; Masayasu Matsumoto
Increased proliferation of neural progenitor cells but reduced survival of newborn cells in the contralateral hippocampus after focal cerebral ischemia in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(3):299-307.
2002: Hideyuki Okano
[Neural stem cells: their identification, isolation and potential therapeutic application].
Seikagaku. The Journal of Japanese Biochemical Society 2002;74(1):17-26.
2001: Hideyuki Okano
[Neural stem cells: the basic biology and prospects for brain repair].
Rinshō shinkeigaku = Clinical neurology 2001;41(12):1036-40.
2001: Naoki Yamamoto; Shigeru Yamamoto; F Inagaki; M Kawaichi; Akiyoshi Fukamizu; N Kishi; K Matsuno; Kozo Nakamura; G Weinmaster; Hideyuki Okano; Masato Nakafuku
Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.
The Journal of biological chemistry 2001;276(48):45031-40.
2001: S i Sakakibara; Yusuke Nakamura; H Satoh; Hideyuki Okano
Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(20):8091-107.
2001: Kazunobu Sawamoto; Akitsugu Yamamoto; A Kawaguchi; M Yamaguchi; K Mori; Steven Goldman; Hideyuki Okano
Direct isolation of committed neuronal progenitor cells from transgenic mice coexpressing spectrally distinct fluorescent proteins regulated by stage-specific neural promoters.
Journal of neuroscience research 2001;65(3):220-7.
2001: Yoshiki Yagita; Kazuo Kitagawa; Toshiho Ohtsuki; Takaki Miyata; Hideyuki Okano; Masatsugu Hori; Masayasu Matsumoto
Neurogenesis by progenitor cells in the ischemic adult rat hippocampus.
Stroke; a journal of cerebral circulation 2001;32(8):1890-6.
2001: Takao Imai; Akinori Tokunaga; T Yoshida; M Hashimoto; K Mikoshiba; G Weinmaster; Masato Nakafuku; Hideyuki Okano
The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA.
Molecular and cellular biology 2001;21(12):3888-900.
2001: Kazunobu Sawamoto; N Nakao; K Kakishita; Y Ogawa; Y Toyama; Akitsugu Yamamoto; M Yamaguchi; K Mori; Steven Goldman; T Itakura; Hideyuki Okano
Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgene.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(11):3895-903.
2001: Kazunobu Sawamoto; N Nakao; K Kobayashi; N Matsushita; H Takahashi; K Kakishita; Akitsugu Yamamoto; T Yoshizaki; T Terashima; F Murakami; T Itakura; Hideyuki Okano
Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6423-8.
2001: Hiroshi Mori; S Sakakibara ; Takao Imai; Yutaka Nakamura; T Iijima; A Suzuki; Y Yuasa; Masatoshi Takeda; Hideyuki Okano
Expression of mouse igf2 mRNA-binding protein 3 and its implications for the developing central nervous system.
Journal of neuroscience research 2001;64(2):132-43.
2001: M Toda; Y Iizuka; W Yu; Takao Imai; E Ikeda; K Yoshida; T Kawase; Y Kawakami; Hideyuki Okano; K Uyemura
Expression of the neural RNA-binding protein Musashi1 in human gliomas.
Glia 2001;34(1):1-7.
2001: Wado Akamatsu; Hideyuki Okano
[Neural stem cell, as a source of graft material for transplantation in neuronal disease].
No to hattatsu. Brain and development 2001;33(2):114-20.
2001: N Kishi; Z Tang; Yusuke Maeda; A Hirai; R Mo; M Ito; S Suzuki; Kazuwa Nakao; Taroh Kinoshita; Tom Kadesch; C c Hui; Spyros Artavanis-Tsakonas; Hideyuki Okano; K Matsuno
Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2001;19(1):21-35.
2001: A Kawaguchi; Takaki Miyata; Kazunobu Sawamoto; N Takashita; Ayako Murayama; Wado Akamatsu; Minetaro Ogawa; M Okabe; Y Tano; Steven Goldman; Hideyuki Okano
Nestin-EGFP transgenic mice: visualization of the self-renewal and multipotency of CNS stem cells.
Molecular and cellular neurosciences 2001;17(2):259-73.
2001: Isao Oishi; Kenji Iwai; Y Kagohashi; Hiroko Fujimoto; Ken-Ichi Kariya; Tohru Kataoka; Hitoshi Sawa; Hideyuki Okano; H Otani; Hirohei Yamamura; Yasuhiro Minami
Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination.
Molecular and cellular biology 2001;21(4):1329-35.
2001: S Hisahara; J Yuan; T Momoi; Hideyuki Okano; Masayuki Miura
Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination.
The Journal of experimental medicine 2001;193(1):111-22.
2000: Hideyuki Okano; T Hirano; E Balaban
Learning and memory.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12403-4.
2000: A Yoda; H Sawa; Hideyuki Okano
MSI-1, a neural RNA-binding protein, is involved in male mating behaviour in Caenorhabditis elegans.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(11):885-895.
2000: H Sawa; H Kouike; Hideyuki Okano
Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans.
Molecular cell 2000;6(3):617-24.
2000: Hideyuki Okano
[Neural stem cells].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(13 Suppl):2063-77.
2000: Masahiro Shibata; S Hisahara; H Hara; Takemori Yamawaki; Yasuo Fukuuchi; J Yuan; Hideyuki Okano; Masayuki Miura
Caspases determine the vulnerability of oligodendrocytes in the ischemic brain.
The Journal of clinical investigation 2000;106(5):643-53.
2000: R Takano; S Hisahara; K Namikawa; Hiroshi Kiyama; Hideyuki Okano; Masayuki Miura
Nerve growth factor protects oligodendrocytes from tumor necrosis factor-alpha-induced injury through Akt-mediated signaling mechanisms.
The Journal of biological chemistry 2000;275(21):16360-5.
2000: T Araki; Masahiro Shibata; R Takano; S Hisahara; S i Imamura; Yasuo Fukuuchi; T Saruta; Hideyuki Okano; Masayuki Miura
Conditional expression of anti-apoptotic protein p35 by Cre-mediated DNA recombination in cardiomyocytes from loxP-p35-transgenic mice.
Cell death and differentiation 2000;7(5):485-92.
2000: MH Jin; Kazunobu Sawamoto; M Ito; Hideyuki Okano
The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor.
Molecular and cellular biology 2000;20(6):2098-107.
2000: S Hisahara; T Araki; F Sugiyama; Ken-ichi Yagami; M Suzuki; K Abe; K Yamamura; J Miyazaki; T Momoi; T Saruta; C C Bernard; Hideyuki Okano; Masayuki Miura
Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune-mediated demyelination.
The EMBO journal 2000;19(3):341-8.
2000: Tatsushi Igaki; Hirotaka Kanuka; Naohiro Inohara; Kazunobu Sawamoto; G Núñez; Hideyuki Okano; Masayuki Miura
Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):662-7.
2000: S Hisahara; R Takano; S Shoji; Hideyuki Okano; Masayuki Miura
Role of caspase-1 subfamily in cytotoxic cytokine-induced oligodendrocyte cell death.
Journal of neural transmission. Supplementum 2000;(58):135-42.
2000: Takuya Ohtani; Katsuhiko Ishihara; Toru Atsumi; Kazuhiko Nishida; Y Kaneko; T Miyata; Shinobu Itoh; Masahiro Narimatsu; H Maeda; Toshiyuki Fukada; Motoyuki Itoh; Hideyuki Okano; Masahiko Hibi; Toshio Hirano
Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.
Immunity 2000;12(1):95-105.
2000: K Tabuchi; Kazunobu Sawamoto; Emiko Matsumoto Suzuki; Koichi Ozaki; M Sone; C Hama; T Tanifuji-Morimoto; Y Yuasa; Y Yoshihara; A Nose; Hideyuki Okano
GAL4/UAS-WGA system as a powerful tool for tracing Drosophila transsynaptic neural pathways.
Journal of neuroscience research 2000;59(1):94-9.
2000: Y Kaneko; S Sakakibara; Takao Imai; A Suzuki; Y Nakamura; Kazunobu Sawamoto; Y Ogawa; Y Toyama; T Miyata; Hideyuki Okano
Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells.
Developmental neuroscience 2000;22(1-2):139-53.
2000: Yusuke Nakamura; S i Sakakibara; Takaki Miyata; Minetaro Ogawa; T Shimazaki; S Weiss; R Kageyama; Hideyuki Okano
The bHLH gene hes1 as a repressor of the neuronal commitment of CNS stem cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(1):283-93.
1999: Hirotaka Kanuka; Kazunobu Sawamoto; Naohiro Inohara; K Matsuno; Hideyuki Okano; Masayuki Miura
Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator.
Molecular cell 1999;4(5):757-69.
1999: J Fujimoto; Kazunobu Sawamoto; M Okabe; Y Takagi; Tohru Tezuka; Shinya Yoshikawa; H Ryo; Hideyuki Okano; Tadashi Yamamoto
Cloning and characterization of Dfak56, a homolog of focal adhesion kinase, in Drosophila melanogaster.
The Journal of biological chemistry 1999;274(41):29196-201.
1999: Y Hirota; M Okabe; Takao Imai; M Kurusu; A Yamamoto; S Miyao; M Nakamura; Kazunobu Sawamoto; Hideyuki Okano
Musashi and seven in absentia downregulate Tramtrack through distinct mechanisms in Drosophila eye development.
Mechanisms of development 1999;87(1-2):93-101.
1999: Wado Akamatsu; Hideyuki Okano; N Osumi; Tomoyuki Inoue; Shun Nakamura; Shuhei Sakakibara; Masayuki Miura; N Matsuo; R B Darnell; H Okano
Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9885-90.
1999: Kazunobu Sawamoto; P Winge; S Koyama; Y Hirota; C Yamada; S Miyao; S Yoshikawa; MH Jin; A Kikuchi; Hideyuki Okano
The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathway.
The Journal of cell biology 1999;146(2):361-72.
1999: T Araki; Takao Saruta; Hideyuki Okano; M Miura
Caspase activity is required for nephrogenesis in the developing mouse metanephros.
Experimental cell research 1999;248(2):423-9.
1999: Kazunobu Sawamoto; C Yamada; S Kishida; Y Hirota; A Taguchi; A Kikuchi; Hideyuki Okano
Ectopic expression of constitutively activated Ral GTPase inhibits cell shape changes during Drosophila eye development.
Oncogene 1999;18(11):1967-74.
1999: Hisashi Umemori; Y Kadowaki; Kazushige Hirosawa; Y Yoshida; K Hironaka; Hideyuki Okano; Tadashi Yamamoto
Stimulation of myelin basic protein gene transcription by Fyn tyrosine kinase for myelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(4):1393-7.
1999: Hirotaka Kanuka; S Hisahara; Kazunobu Sawamoto; S Shoji; Hideyuki Okano; Masayuki Miura
Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: implicated mechanisms for caspase activation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):145-50.
1998: K Tabuchi; S Yoshikawa; Y Yuasa; Kazunobu Sawamoto; Hideyuki Okano
A novel Drosophila paired-like homeobox gene related to Caenorhabditis elegans unc-4 is expressed in subsets of postmitotic neurons and epidermal cells.
Neuroscience letters 1998;257(1):49-52.
1998: Hideyuki Okano; M S Cyert; Yoshikazu Ohya
Importance of phenylalanine residues of yeast calmodulin for target binding and activation.
The Journal of biological chemistry 1998;273(41):26375-82.
1998: Kazunobu Sawamoto; A Taguchi; Y Hirota; C Yamada; MH Jin; Hideyuki Okano
Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway.
Cell death and differentiation 1998;5(4):262-70.
1998: S Hisahara; Hirotaka Kanuka; S Shoji; S Yoshikawa; Hideyuki Okano; Masayuki Miura
Caenorhabditis elegans anti-apoptotic gene ced-9 prevents ced-3-induced cell death in Drosophila cells.
Journal of cell science 1998;111 ( Pt 6)():667-73.
1997: S i Sakakibara; Hideyuki Okano
Expression of neural RNA-binding proteins in the postnatal CNS: implications of their roles in neuronal and glial cell development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(21):8300-12.
1997: C F Fletcher; Hideyuki Okano; D J Gilbert; Y Yang; C Yang; N G Copeland; N A Jenkins; Robert B Darnell
Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.
Genomics 1997;45(2):313-9.
1997: Hideyuki Okano; M Okabe; A Taguchi; Kazunobu Sawamoto
Evolutionarily conserved mechanisms regulating neural development: lessons from the development of Drosophila peripheral nervous systems.
Human cell 1997;10(3):139-50.
1997: Shoen Kume; A Yamamoto; TAKANARI INOUE; Akihiko Muto; Hideyuki Okano; Katsuhiko Mikoshiba
Developmental expression of the inositol 1,4,5-trisphosphate receptor and structural changes in the endoplasmic reticulum during oogenesis and meiotic maturation of Xenopus laevis.
Developmental biology 1997;182(2):228-39.
1997: Masayuki Miura; S Hisahara; T Araki; Hideyuki Okano
Execution mechanisms of programmed cell death by caspase (ICE/CED-3) family proteases.
Heart and vessels 1997;Suppl 12():66-70.
1997: M Okabe; Kazunobu Sawamoto; Takao Imai; S Sakakibara; S Yoshikawa; Hideyuki Okano
Intrinsic and extrinsic determinants regulating cell fate decision in developing nervous system.
Developmental neuroscience 1997;19(1):9-16.
1996: Kazunobu Sawamoto; Hideyuki Okano
Cell-cell interactions during neural development: multiple types of lateral inhibitions involved in Drosophila eye development.
Neuroscience research 1996;26(3):205-14.
1996: Kazunobu Sawamoto; M Okabe; T Tanimura; K Mikoshiba; Y Nishida; Hideyuki Okano
The Drosophila secreted protein Argos regulates signal transduction in the Ras/MAPK pathway.
Developmental biology 1996;178(1):13-22.
1996: J Chen; S Chang; SA Duncan; Hideyuki Okano; Gord Fishell; Alan Aderem
Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6275-9.
1996: M Okabe; Kazunobu Sawamoto; Hideyuki Okano
The function of the Drosophila argos gene product in the development of embryonic chordotonal organs.
Developmental biology 1996;175(1):37-49.
1996: Kazunobu Sawamoto; M Okabe; T Tanimura; S Hayashi; K Mikoshiba; Hideyuki Okano
argos Is required for projection of photoreceptor axons during optic lobe development in Drosophila.
Developmental dynamics : an official publication of the American Association of Anatomists 1996;205(2):162-71.
1996: M Matsumoto; T Nakagawa; TAKANARI INOUE; E Nagata; K Tanaka; H Takano; Osamu Minowa; Junko Kuno; S Sakakibara; Maki K Yamada; H Yoneshima; Atsushi Miyawaki; Y Fukuuchi; Teiichi Furuichi; Hideyuki Okano; K Mikoshiba; T Noda
Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor.
Nature 1996;379(6561):168-71.
1996: Hideyuki Okano; Donald Pfaff; Robert B Gibbs
Expression of EGFR-, p75NGFR-, and PSTAIR (cdc2)-like immunoreactivity by proliferating cells in the adult rat hippocampal formation and forebrain.
Developmental neuroscience 1996;18(3):199-209.
1995: L S Newman; M O McKeever; Hideyuki Okano; Robert B Darnell
Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein.
Cell 1995;82(5):773-83.
1995: Y Ohnishi; S Kubo; Y Ono; Masami Nozaki; Y Gonda; Hideyuki Okano; T Matsuya; A Matsushiro; T Morita
Cloning and sequencing of the gene coding for dextranase from Streptococcus salivarius.
Gene 1995;156(1):93-6.
1994: Hideyuki Okano; S Yoshikawa; Akinori Suzuki; N Ueno; M Kaizu; M Okabe; T Takahashi; M Matsumoto; Kazunobu Sawamoto; K Mikoshiba
Cloning of a Drosophila melanogaster homologue of the mouse type-I bone morphogenetic proteins-2/-4 receptor: a potential decapentaplegic receptor.
Gene 1994;148(2):203-9.
1994: Kazunobu Sawamoto; Hideyuki Okano; Yoshitaka Kobayakawa; S Hayashi; K Mikoshiba; T Tanimura
The function of argos in regulating cell fate decisions during Drosophila eye and wing vein development.
Developmental biology 1994;164(1):267-76.
1993: K Mikoshiba; Teiichi Furuichi; Atsushi Miyawaki; S Yoshikawa; S Nakade; Takayuki Michikawa; T Nakagawa; Hideyuki Okano; S Kume; Akihiko Muto
Structure and function of inositol 1,4,5-trisphosphate receptor.
Annals of the New York Academy of Sciences 1993;707():178-97.
1993: Hideyuki Okano; Donald Pfaff; Robert B Gibbs
RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(7):2930-8.
1993: S Kume; Akihiko Muto; Jun Aruga; T Nakagawa; Takayuki Michikawa; Teiichi Furuichi; S Nakade; Hideyuki Okano; K Mikoshiba
The Xenopus IP3 receptor: structure, function, and localization in oocytes and eggs.
Cell 1993;73(3):555-70.
1993: S Yoshikawa; I Miyamoto; Jun Aruga; Teiichi Furuichi; Hideyuki Okano; K Mikoshiba
Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase.
Journal of neurochemistry 1993;60(4):1570-3.
1992: Hideyuki Okano; S Hayashi; T Tanimura; Kazunobu Sawamoto; S Yoshikawa; J Watanabe; M Iwasaki; S Hirose; K Mikoshiba; Craig Montell
Regulation of Drosophila neural development by a putative secreted protein.
Differentiation; research in biological diversity 1992;52(1):1-11.
1992: Hideyuki Okano; Donald Pfaff; Robert B Gibbs
Role of local environmental factors in determining tissue-specific effects of estrogen: examination of uterine tissues transplanted to brain.
Molecular and cellular endocrinology 1992;87(1-3):179-92.
1992: K Mikoshiba; Teiichi Furuichi; Atsushi Miyawaki; S Yoshikawa; Nobuji Maeda; M Niinobe; S Nakade; T Nakagawa; Hideyuki Okano; Jun Aruga
The inositol 1,4,5-trisphosphate receptor.
Ciba Foundation symposium 1992;164():17-29; discussion 29-35.
1992: K Mikoshiba; Teiichi Furuichi; Atsushi Miyawaki; S Yoshikawa; T Nakagawa; Jun Aruga; Hideyuki Okano; Nobuhiro Yamada
Inositol 1,4,5-trisphosphate (IP3) receptors.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():62A-63A.
1991: T Nakagawa; C Shiota; Hideyuki Okano; K Mikoshiba
Differential localization of alternative spliced transcripts encoding inositol 1,4,5-trisphosphate receptors in mouse cerebellum and hippocampus: in situ hybridization study.
Journal of neurochemistry 1991;57(5):1807-10.
1991: T Nakagawa; Hideyuki Okano; Teiichi Furuichi; Jun Aruga; K Mikoshiba
The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6244-8.
1991: Jun Aruga; Hideyuki Okano; K Mikoshiba
Identification of the new isoforms of mouse myelin basic protein: the existence of exon 5a.
Journal of neurochemistry 1991;56(4):1222-6.
1991: Hideyuki Okano; Jun Aruga; T Nakagawa; C Shiota; K Mikoshiba
Myelin basic protein gene and the function of antisense RNA in its repression in myelin-deficient mutant mouse.
Journal of neurochemistry 1991;56(2):560-7.
1991: K Mikoshiba; Hideyuki Okano; T Tamura; Kazuhiro Ikenaka
Structure and function of myelin protein genes.
Annual review of neuroscience 1991;14():201-17.
1991: K Mikoshiba; Jun Aruga; Hideyuki Okano
Molecular biology of myelin basic protein: gene rearrangement and expression of anti-sense RNA in myelin-deficient mutants.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1991;98(1):51-61.
1990: K Mikoshiba; Hideyuki Okano; Jun Aruga; T Tamura; M Miura; Kazuhiro Ikenaka; T Nakagawa
Chimeric and molecular genetic analysis of myelin-deficient (shiverer and mld) mutant mice.
Annals of the New York Academy of Sciences 1990;605():166-82.
1988: Hideyuki Okano; Kazuhiro Ikenaka; K Mikoshiba
Recombination within the upstream gene of duplicated myelin basic protein genes of myelin deficient shimld mouse results in the production of antisense RNA.
The EMBO journal 1988;7(11):3407-12.
1988: Kazuhiro Ikenaka; Teiichi Furuichi; Y Iwasaki; A Moriguchi; Hideyuki Okano; K Mikoshiba
Myelin proteolipid protein gene structure and its regulation of expression in normal and jimpy mutant mice.
Journal of molecular biology 1988;199(4):587-96.
1988: Hideyuki Okano; T Tamura; M Miura; A Aoyama; Kazuhiro Ikenaka; M Oshimura; K Mikoshiba
Gene organization and transcription of duplicated MBP genes of myelin deficient (shi(mld)) mutant mouse.
The EMBO journal 1988;7(1):77-83.
1987: K Mikoshiba; Hideyuki Okano; Y Inoue; M Fujishiro; K Takamatsu; F Lachapelle; N Baumann; Y Tsukada
Immunohistochemical, biochemical and electron microscopic analysis of myelin formation in the central nervous system of myelin deficient (mld) mutant mice.
Brain research 1987;432(1):111-21.
1987: A Moriguchi; Kazuhiro Ikenaka; Teiichi Furuichi; Hideyuki Okano; Y Iwasaki; K Mikoshiba
The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice.
Gene 1987;55(2-3):333-7.