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Toshiyuki Okano

Research Profile

Chemicals & Drugs

Living Beings

Chickens

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Publications

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Tsuyoshi Hirota; Naohiro Kon; Takashi Itagaki; Naosuke Hoshina; Toshiyuki Okano; Yoshitaka Fukada
Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork.
Momoko Sasaki; Hikari Yoshitane; Ngoc-Hien Du; Toshiyuki Okano; Yoshitaka Fukada
Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription.
Hikari Yoshitane; Toshifumi Takao; Yoshinori Satomi; Ngoc-Hien Du; Toshiyuki Okano; Yoshitaka Fukada
Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription.

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All Publications

2010: Tsuyoshi Hirota; Naohiro Kon; Takashi Itagaki; Naosuke Hoshina; Toshiyuki Okano; Yoshitaka Fukada
Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork.
Genes to cells : devoted to molecular & cellular mechanisms 2010;15(2):111-21.
2009: Momoko Sasaki; Hikari Yoshitane; Ngoc-Hien Du; Toshiyuki Okano; Yoshitaka Fukada
Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription.
The Journal of biological chemistry 2009;284(37):25149-59.
2009: Hikari Yoshitane; Toshifumi Takao; Yoshinori Satomi; Ngoc-Hien Du; Toshiyuki Okano; Yoshitaka Fukada
Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription.
Molecular and cellular biology 2009;29(13):3675-86.
2007: Masaki Torii; Daisuke Kojima; Toshiyuki Okano; Atsushi Nakamura; Akihisa Terakita; Yoshinori Shichida; Akimori Wada; Yoshitaka Fukada
Two isoforms of chicken melanopsins show blue light sensitivity.
FEBS letters 2007;581(27):5327-31.
2007: Nobuhiro Nakao; Shinobu Yasuo; Atsuko Nishimura; Takashi Yamamura; Tsuyoshi Watanabe; Tsubasa Anraku; Toshiyuki Okano; Yoshitaka Fukada; Peter J Sharp; Shizufumi Ebihara; Takashi Yoshimura
Circadian clock gene regulation of steroidogenic acute regulatory protein gene expression in preovulatory ovarian follicles.
Endocrinology 2007;148(7):3031-8.
2006: Yasutaka Wada; Junichi Sugiyama; Toshiyuki Okano; Yoshitaka Fukada
GRK1 and GRK7: unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones.
Journal of neurochemistry 2006;98(3):824-37.
2006: Yoko Kubo; Masashi Akiyama; Yoshitaka Fukada; Toshiyuki Okano
Molecular cloning, mRNA expression, and immunocytochemical localization of a putative blue-light photoreceptor CRY4 in the chicken pineal gland.
Journal of neurochemistry 2006;97(4):1155-65.
2006: Megumi Hatori; Toshiyuki Okano; Yoshito Nakajima; Masao Doi; Yoshitaka Fukada
Lcg is a light-inducible and clock-controlled gene expressed in the chicken pineal gland.
Journal of neurochemistry 2006;96(6):1790-800.
2005: Hidetoshi Kassai; Atsu Aiba; Kazuki Nakao; Kenji Nakamura; Motoya Katsuki; Wei-Hong Xiong; King-Wai Yau; Hiroo Imai; Yoshinori Shichida; Yoshinori Satomi; Toshifumi Takao; Toshiyuki Okano; Yoshitaka Fukada
Farnesylation of retinal transducin underlies its translocation during light adaptation.
Neuron 2005;47(4):529-39.
2004: Masao Doi; Toshiyuki Okano; Irene Yujnovsky; Paolo Sassone-Corsi; Yoshitaka Fukada
Negative control of circadian clock regulator E4BP4 by casein kinase Iepsilon-mediated phosphorylation.
Current biology : CB 2004;14(11):975-80.
2003: Toshiyuki Okano; Yoshitaka Fukada
Chicktacking pineal clock.
Journal of biochemistry 2003;134(6):791-7.
2002: Tsuyoshi Hirota; Toshiyuki Okano; Koichi Kokame; Hiroko Shirotani-Ikejima; Toshiyuki Miyata; Yoshitaka Fukada
Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts.
The Journal of biological chemistry 2002;277(46):44244-51.
2002: Takaoki Kasahara; Toshiyuki Okano; Tatsuya Haga; Yoshitaka Fukada
Opsin-G11-mediated signaling pathway for photic entrainment of the chicken pineal circadian clock.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(17):7321-5.
2002: Masao Doi; Yoshito Nakajima; Toshiyuki Okano; Yoshitaka Fukada
Light-dependent changes in the chick pineal temperature and the expression of cHsp90 alpha gene: a potential contribution of in vivo temperature change to the photic-entrainment of the chick pineal circadian clock.
Zoological science 2002;19(6):633-41.
2002: Yoko Takanaka; Toshiyuki Okano; Kazuyuki Yamamoto; Yoshitaka Fukada
A negative regulatory element required for light-dependent pinopsin gene expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(11):4357-63.
2002: Yoshitaka Fukada; Toshiyuki Okano
Circadian clock system in the pineal gland.
Molecular neurobiology 2002;25(1):19-30.
2002: Kamon Sanada; Toshiyuki Okano; Yoshitaka Fukada
Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1.
The Journal of biological chemistry 2002;277(1):267-71.
2001: Kazuyuki Yamamoto; Toshiyuki Okano; Yoshitaka Fukada
Chicken pineal Cry genes: light-dependent up-regulation of cCry1 and cCry2 transcripts.
Neuroscience letters 2001;313(1-2):13-6.
2001: Toshiyuki Okano; Kazuyuki Yamamoto; K Okano; Tsuyoshi Hirota; Takaoki Kasahara; M Sasaki; Yoko Takanaka; Yoshitaka Fukada
Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(9):825-36.
2001: Masao Doi; Yoshito Nakajima; Toshiyuki Okano; Yoshitaka Fukada
Light-induced phase-delay of the chicken pineal circadian clock is associated with the induction of cE4bp4, a potential transcriptional repressor of cPer2 gene.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):8089-94.
2001: Toshiyuki Okano; Yoshitaka Fukada
Photoreception and circadian clock system of the chicken pineal gland.
Microscopy research and technique 2001;53(1):72-80.
2001: Toshiyuki Okano; Mitsuyoshi Sasaki; Yoshitaka Fukada
Cloning of mouse BMAL2 and its daily expression profile in the suprachiasmatic nucleus: a remarkable acceleration of Bmal2 sequence divergence after Bmal gene duplication.
Neuroscience letters 2001;300(2):111-4.
2001: Atsushi Nakamura; Daisuke Kojima; Toshiyuki Okano; Hiroo Imai; Akihisa Terakita; Yoshinori Shichida; Yoshitaka Fukada
Regulatory mechanism for the stability of the meta II intermediate of pinopsin.
Journal of biochemistry 2001;129(2):329-34.
2001: Tsuyoshi Hirota; Satoshi Kagiwada; Takaoki Kasahara; Toshiyuki Okano; Masayuki Murata; Yoshitaka Fukada
Effect of brefeldin A on melatonin secretion of chick pineal cells.
Journal of biochemistry 2001;129(1):51-9.
2000: Y Wada; Toshiyuki Okano; Yoshitaka Fukada
Phototransduction molecules in the pigeon deep brain.
The Journal of comparative neurology 2000;428(1):138-44.
2000: Takaoki Kasahara; Toshiyuki Okano; T Yoshikawa; K Yamazaki; Yoshitaka Fukada
Rod-type transducin alpha-subunit mediates a phototransduction pathway in the chicken pineal gland.
Journal of neurochemistry 2000;75(1):217-24.
2000: A Matsushita; T Yoshikawa; Toshiyuki Okano; Takaoki Kasahara; Yoshitaka Fukada
Colocalization of pinopsin with two types of G-protein alpha-subunits in the chicken pineal gland.
Cell and tissue research 2000;299(2):245-51.
2000: Kamon Sanada; Yasuhide Hayashi; Yoshifumi Harada; Toshiyuki Okano; Yoshitaka Fukada
Role of circadian activation of mitogen-activated protein kinase in chick pineal clock oscillation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(3):986-91.
2000: Toshiyuki Okano; Yoshitaka Fukada
Photoreceptors in pineal gland and brain: cloning, localization, and overexpression.
Methods in enzymology 2000;316():278-91.
1999: Atsushi Nakamura; Daisuke Kojima; Hiroo Imai; Akihisa Terakita; Toshiyuki Okano; Yoshinori Shichida; Yoshitaka Fukada
Chimeric nature of pinopsin between rod and cone visual pigments.
Biochemistry 1999;38(45):14738-45.
1998: Y Wada; Toshiyuki Okano; Akihiko Adachi; Shizufumi Ebihara; Yoshitaka Fukada
Identification of rhodopsin in the pigeon deep brain.
FEBS letters 1998;424(1-2):53-6.
1998: Yoko Takanaka; Toshiyuki Okano; Masayuki Iigo; Yoshitaka Fukada
Light-dependent expression of pinopsin gene in chicken pineal gland.
Journal of neurochemistry 1998;70(3):908-13.
1997: Toshiyuki Okano; Yoko Takanaka; Atsushi Nakamura; Kanjun Hirunagi; Akihiko Adachi; Shizufumi Ebihara; Yoshitaka Fukada
Immunocytochemical identification of pinopsin in pineal glands of chicken and pigeon.
Brain research. Molecular brain research 1997;50(1-2):190-6.
1997: Kanjun Hirunagi; Shizufumi Ebihara; Toshiyuki Okano; Yoko Takanaka; Yoshitaka Fukada
Immunoelectron-microscopic investigation of the subcellular localization of pinopsin in the pineal organ of the chicken.
Cell and tissue research 1997;289(2):235-41.
1997: Toshiyuki Okano; Yoshitaka Fukada
Phototransduction cascade and circadian oscillator in chicken pineal gland.
Journal of pineal research 1997;22(3):145-51.
1997: Toshiyuki Okano; K Yamazaki; Takaoki Kasahara; Yoshitaka Fukada
Molecular cloning of heterotrimeric G-protein alpha-subunits in chicken pineal gland.
Journal of molecular evolution 1997;44 Suppl 1():S91-7.
1995: Toshiyuki Okano; Yoshitaka Fukada; T Yoshizawa
Molecular basis for tetrachromatic color vision.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1995;112(3):405-14.
1995: Yoshitaka Fukada; Toshiyuki Okano
[Molecular analysis of biological clocks].
Seikagaku. The Journal of Japanese Biochemical Society 1995;67(9):1137-42.
1995: Daisuke Kojima; Hiroo Imai; Toshiyuki Okano; Yoshitaka Fukada; F Crescitelli; T Yoshizawa; Yoshinori Shichida
Purification and low temperature spectroscopy of gecko visual pigments green and blue.
Biochemistry 1995;34(3):1096-106.
1994: Toshiyuki Okano; T Yoshizawa; Yoshitaka Fukada
Pinopsin is a chicken pineal photoreceptive molecule.
Nature 1994;372(6501):94-7.
1992: Toshiyuki Okano; Yoshitaka Fukada; Yoshinori Shichida; T Yoshizawa
Photosensitivities of iodopsin and rhodopsins.
Photochemistry and photobiology 1992;56(6):995-1001.
1992: Daisuke Kojima; Toshiyuki Okano; Yoshitaka Fukada; Yoshinori Shichida; T Yoshizawa; T G Ebrey
Cone visual pigments are present in gecko rod cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):6841-5.
1992: Toshiyuki Okano; Daisuke Kojima; Yoshitaka Fukada; Yoshinori Shichida; T Yoshizawa
Primary structures of chicken cone visual pigments: vertebrate rhodopsins have evolved out of cone visual pigments.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):5932-6.
1990: Yoshitaka Fukada; K Kokame; Toshiyuki Okano; Yoshinori Shichida; T Yoshizawa; J Hugh McDowell; Paul A Hargrave; K Palczewski
Phosphorylation of iodopsin, chicken red-sensitive cone visual pigment.
Biochemistry 1990;29(43):10102-6.
1990: O Kuwata; Yasushi Imamoto; Toshiyuki Okano; K Kokame; Daisuke Kojima; H Matsumoto; A Morodome; Yoshitaka Fukada; Yoshinori Shichida; K Yasuda
The primary structure of iodopsin, a chicken red-sensitive cone pigment.
FEBS letters 1990;272(1-2):128-32.
1990: Yoshitaka Fukada; Toshiyuki Okano; Yoshinori Shichida; T Yoshizawa; A Trehan; D Mead; M Denny; A E Asato; R S Liu
Comparative study on the chromophore binding sites of rod and red-sensitive cone visual pigments by use of synthetic retinal isomers and analogues.
Biochemistry 1990;29(12):3133-40.
1989: Yasushi Imamoto; Hideki Kandori; Toshiyuki Okano; Yoshitaka Fukada; Yoshinori Shichida; T Yoshizawa
Effect of chloride ion on the thermal decay process of the batho intermediate of iodopsin at low temperature.
Biochemistry 1989;28(24):9412-6.
1989: Toshiyuki Okano; Yoshitaka Fukada; I D Artamonov; T Yoshizawa
Purification of cone visual pigments from chicken retina.
Biochemistry 1989;28(22):8848-56.
1989: Yoshitaka Fukada; Toshiyuki Okano; I D Artamonov; T Yoshizawa
Chicken red-sensitive cone visual pigment retains a binding domain for transducin.
FEBS letters 1989;246(1-2):69-72.