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Takashi Okauchi

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Takeaki Saijo; Tetsuya Suhara; Masayuki Suzuki; Toshimitsu Fukumura; Nobuharu Goto; Yasuhiro Kuwahara; Jun Maeda; Jun-ichi Maeda; Yasunori Morio; Takashi Okauchi; Makoto Higuchi
Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain.
Jun Maeda; Ming-Rong Zhang; Takashi Okauchi; Bin Ji; Maiko Ono; Satoko Hattori; Katsushi Kumata; Nobuhisa Iwata; Takaomi C Saido; John Q Trojanowski; Virginia M-Y Lee; Matthias Staufenbiel; Takami Tomiyama; Hiroshi Mori; Toshimitsu Fukumura; Tetsuya Suhara; Makoto Higuchi
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
Iwae Yu; Motoki Inaji; Jun Maeda; Takashi Okauchi; Tadashi Nariai; Kikuo Ohno; Makoto Higuchi; Tetsuya Suhara
Glial cell-mediated deterioration and repair of the nervous system after traumatic brain injury in a rat model as assessed by positron emission tomography.

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All Publications

2012: Takeaki Saijo; Tetsuya Suhara; Masayuki Suzuki; Toshimitsu Fukumura; Nobuharu Goto; Yasuhiro Kuwahara; Jun Maeda; Jun-ichi Maeda; Yasunori Morio; Takashi Okauchi; Makoto Higuchi
Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain.
PloS one 2012;7(8):e42589.
2011: Jun Maeda; Ming-Rong Zhang; Takashi Okauchi; Bin Ji; Maiko Ono; Satoko Hattori; Katsushi Kumata; Nobuhisa Iwata; Takaomi C Saido; John Q Trojanowski; Virginia M-Y Lee; Matthias Staufenbiel; Takami Tomiyama; Hiroshi Mori; Toshimitsu Fukumura; Tetsuya Suhara; Makoto Higuchi
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(12):4720-30.
2010: Iwae Yu; Motoki Inaji; Jun Maeda; Takashi Okauchi; Tadashi Nariai; Kikuo Ohno; Makoto Higuchi; Tetsuya Suhara
Glial cell-mediated deterioration and repair of the nervous system after traumatic brain injury in a rat model as assessed by positron emission tomography.
Journal of neurotrauma 2010;27(8):1463-75.
2010: Makoto Higuchi; Jun Maeda; Bin Ji; Masahiro Maruyama; Takashi Okauchi; Masaki Tokunaga; Maiko Ono; Tetsuya Suhara
In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: Insights from neuroimaging research in humans and rodent models.
Biochimica et biophysica acta 2010;1802(4):373-88.
2009: Takeaki Saijo; Jun Maeda; Takashi Okauchi; Jun Maeda; Yasunori Morio; Yasuhiro Kuwahara; Masayuki Suzuki; Nobuharu Goto; Kazutoshi Suzuki; Makoto Higuchi; Tetsuya Suhara
Utility of small-animal positron emission tomographic imaging of rats for preclinical development of drugs acting on the serotonin transporter.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009;12(8):1021-32.
2009: Takeshi Fuchigami; Terushi Haradahira; Noriko Fujimoto; Yumiko Nojiri; Takahiro Mukai; Fumihiko Yamamoto; Takashi Okauchi; Jun Maeda; Kazutoshi Suzuki; Tetsuya Suhara; Hiroshi Yamaguchi; Mikako Ogawa; Yasuhiro Magata; Minoru Maeda
Development of N-[11C]methylamino 4-hydroxy-2(1H)-quinolone derivatives as PET radioligands for the glycine-binding site of NMDA receptors.
Bioorganic & medicinal chemistry 2009;17(15):5665-75.
2009: Shigeru Obayashi; Yuji Nagai; Tetsuya Suhara; Takashi Okauchi; Motoki Inaji; Atsushi Iriki; Jun Maeda
Monkey brain activity modulated by reward preferences: a positron emission tomography study.
Neuroscience research 2009;64(4):421-8.
2009: Masaki Tokunaga; Nicholas Seneca; Ryong-Moon Shin; Jun Maeda; Shigeru Obayashi; Takashi Okauchi; Yuji Nagai; Ming-Rong Zhang; Ryuji Nakao; Hiroshi Ito; Robert B Innis; Christer Halldin; Kazutoshi Suzuki; Makoto Higuchi; Tetsuya Suhara
Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(6):1887-96.
2008: Bin Ji; Jun Maeda; Makoto Sawada; Maiko Ono; Takashi Okauchi; Motoki Inaji; Ming-Rong Zhang; Kazutoshi Suzuki; Kiyoshi Ando; Matthias Staufenbiel; John Q Trojanowski; Virginia M-Y Lee; Makoto Higuchi; Tetsuya Suhara
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12255-67.
2008: Takeshi Fuchigami; Terushi Haradahira; Noriko Fujimoto; Takashi Okauchi; Jun Maeda; Kazutoshi Suzuki; Tetsuya Suhara; Fumihiko Yamamoto; Shigeki Sasaki; Takahiro Mukai; Hiroshi Yamaguchi; Mikako Ogawa; Yasuhiro Magata; Minoru Maeda
Difference in brain distributions of carbon 11-labeled 4-hydroxy-2(1H)-quinolones as PET radioligands for the glycine-binding site of the NMDA ion channel.
Nuclear medicine and biology 2008;35(2):203-12.
2008: Kiyoshi Ando; Jun Maeda; Motoki Inaji; Takashi Okauchi; Shigeru Obayashi; Makoto Higuchi; Tetsuya Suhara; Yoshikuni Tanioka
Neurobehavioral protection by single dose l-deprenyl against MPTP-induced parkinsonism in common marmosets.
Psychopharmacology 2008;195(4):509-16.
2007: Jun Maeda; Bin Ji; Toshiaki Irie; Takami Tomiyama; Masahiro Maruyama; Takashi Okauchi; Matthias Staufenbiel; Nobuhisa Iwata; Maiko Ono; Takaomi C Saido; Kazutoshi Suzuki; Hiroshi Mori; Makoto Higuchi; Tetsuya Suhara
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(41):10957-68.
2007: Yuji Nagai; Shigeru Obayashi; Kiyoshi Ando; Motoki Inaji; Jun Maeda; Takashi Okauchi; Hiroshi Ito; Tetsuya Suhara
Progressive changes of pre- and post-synaptic dopaminergic biomarkers in conscious MPTP-treated cynomolgus monkeys measured by positron emission tomography.
Synapse (New York, N.Y.) 2007;61(10):809-19.
2007: Jun Maeda; Makoto Higuchi; Motoki Inaji; Bin Ji; Eisuke Haneda; Takashi Okauchi; Ming-Rong Zhang; Kazutoshi Suzuki; Tetsuya Suhara
Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor.
Brain research 2007;1157():100-11.
2007: Eisuke Haneda; Makoto Higuchi; Jun Maeda; Motoki Inaji; Takashi Okauchi; Kiyoshi Ando; Shigeru Obayashi; Yuji Nagai; Michiko Narazaki; Hiroo Ikehira; Ryuji Nakao; Ming-Rong Zhang; Kazutoshi Suzuki; Hidenori Suzuki; Tetsuya Suhara
In vivo mapping of substance P receptors in brains of laboratory animals by high-resolution imaging systems.
Synapse (New York, N.Y.) 2007;61(4):205-15.
2006: Ming-Rong Zhang; Masanao Ogawa; Jun Maeda; Takehito Ito; Junko Noguchi; Katsushi Kumata; Takashi Okauchi; Tetsuya Suhara; Kazutoshi Suzuki
[2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain.
Journal of medicinal chemistry 2006;49(9):2735-42.
2006: Takuya Morimoto; Hiroshi Ito; Akihiro Takano; Yoko Ikoma; Chie Seki; Takashi Okauchi; Katsuyuki Tanimoto; Akira Ando; Takahiro Shiraishi; Taiga Yamaya; Tetsuya Suhara
Effects of image reconstruction algorithm on neurotransmission PET studies in humans: comparison between filtered backprojection and ordered subsets expectation maximization.
Annals of nuclear medicine 2006;20(3):237-43.
2006: Young-Joo Lee; Jun Maeda; Hiroyuki Kusuhara; Takashi Okauchi; Motoki Inaji; Yuji Nagai; Shigeru Obayashi; Ryuji Nakao; Kazutoshi Suzuki; Yuichi Sugiyama; Tetsuya Suhara
In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil.
The Journal of pharmacology and experimental therapeutics 2006;316(2):647-53.
2005: Motoki Inaji; Takashi Okauchi; Kiyoshi Ando; Jun Maeda; Yuji Nagai; Takahito Yoshizaki; Hideyuki Okano; Tadashi Nariai; Kikuo Ohno; Shigeru Obayashi; Makoto Higuchi; Tetsuya Suhara
Correlation between quantitative imaging and behavior in unilaterally 6-OHDA-lesioned rats.
Brain research 2005;1064(1-2):136-45.
2005: Winn Aung; Takashi Okauchi; Masaaki Sato; Toshiyuki Saito; Hidehiko Nakagawa; Hiroshi Ishihara; Nobuo Ikota; Tetsuya Suhara; Kazunori Anzai
In-vivo PET imaging of inducible D2R reporter transgene expression using [11C]FLB 457 as reporter probe in living rats.
Nuclear medicine communications 2005;26(3):259-68.
2005: Ming-Rong Zhang; Jun Maeda; Takehito Ito; Takashi Okauchi; Masanao Ogawa; Junko Noguchi; Tetsuya Suhara; Christer Halldin; Kazutoshi Suzuki
Synthesis and evaluation of N-(5-fluoro-2-phenoxyphenyl)-N-(2-[(18)F]fluoromethoxy-d(2)-5-methoxybenzyl)acetamide: a deuterium-substituted radioligand for peripheral benzodiazepine receptor.
Bioorganic & medicinal chemistry 2005;13(5):1811-8.
2005: Motoki Inaji; Takahito Yoshizaki; Takashi Okauchi; Jun Maeda; Yuji Nagai; Tadashi Nariai; Kikuo Ohno; Kiyoshi Ando; Hideyuki Okano; Shigeru Obayashi; Tetsuya Suhara
In vivo PET measurements with [11C]PE2I to evaluate fetal mesencephalic transplantations to unilateral 6-OHDA-lesioned rats.
Cell transplantation 2005;14(9):655-63.
2004: Jun Maeda; Tetsuya Suhara; Ming-Rong Zhang; Takashi Okauchi; Fumihiko Yasuno; Yoko Ikoma; Motoki Inaji; Yuji Nagai; Akihiro Takano; Shigeru Obayashi; Kazutoshi Suzuki
Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain.
Synapse (New York, N.Y.) 2004;52(4):283-91.
2004: Akihiro Takano; Tetsuya Suhara; Jun Maeda; Kiyoshi Ando; Takashi Okauchi; Shigeru Obayashi; Takashi Nakayama; Shitij Kapur
Relation between cortical dopamine D(2) receptor occupancy and suppression of conditioned avoidance response in non-human primate.
Psychiatry and clinical neurosciences 2004;58(3):330-2.
2004: Ming-Rong Zhang; Jun Maeda; Masanao Ogawa; Junko Noguchi; Takehito Ito; Yuichiro Yoshida; Takashi Okauchi; Shigeru Obayashi; Tetsuya Suhara; Kazutoshi Suzuki
Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain.
Journal of medicinal chemistry 2004;47(9):2228-35.
2004: Shigeki Sasaki; Fumie Kurosaki; Terushi Haradahira; Fumihiko Yamamoto; Jun Maeda; Takashi Okauchi; Kazutoshi Suzuki; Tetsuya Suhara; Minoru Maeda
Synthesis of 11C-labelled bis(phenylalkyl)amines and their in vitro and in vivo binding properties in rodent and monkey brains.
Biological & pharmaceutical bulletin 2004;27(4):531-7.
2004: Shigeru Obayashi; Tetsuya Suhara; Yuji Nagai; Takashi Okauchi; Jun Maeda; Atsushi Iriki
Monkey brain areas underlying remote-controlled operation.
The European journal of neuroscience 2004;19(5):1397-407.
2003: Takeshi Fuchigami; Terushi Haradahira; Takuya Arai; Takashi Okauchi; Jun Maeda; Kazutoshi Suzuki; Fumihiko Yamamoto; Tetsuya Suhara; Shigeki Sasaki; Minoru Maeda
Synthesis and brain regional distribution of [11C]NPS 1506 in mice and rat: an N-methyl-D-aspartate (NMDA) receptor antagonist.
Biological & pharmaceutical bulletin 2003;26(11):1570-3.
2003: Terushi Haradahira; Takashi Okauchi; Jun Maeda; Ming-Rong Zhang; Toru Nishikawa; Ryouichi Konno; Kazutoshi Suzuki; Tetsuya Suhara
Effects of endogenous agonists, glycine and D-serine, on in vivo specific binding of [11C]L-703,717, a PET radioligand for the glycine-binding site of NMDA receptors.
Synapse (New York, N.Y.) 2003;50(2):130-6.
2003: Ming-Rong Zhang; Kenji Furutsuka; Jun Maeda; Tatsuya Kikuchi; Takayo Kida; Takashi Okauchi; Toshiaki Irie; Kazutoshi Suzuki
N-[18F]fluoroethyl-4-piperidyl acetate ([18F]FEtP4A): A PET tracer for imaging brain acetylcholinesterase in vivo.
Bioorganic & medicinal chemistry 2003;11(12):2519-27.
2003: Shigeru Obayashi; Tetsuya Suhara; Kouichi Kawabe; Takashi Okauchi; Jun Maeda; Yuji Nagai; Atsushi Iriki
Fronto-parieto-cerebellar interaction associated with intermanual transfer of monkey tool-use learning.
Neuroscience letters 2003;339(2):123-6.
2003: Jun Maeda; Tetsuya Suhara; Kouichi Kawabe; Takashi Okauchi; Shigeru Obayashi; Junko Hojo; Kazutoshi Suzuki
Visualization of alpha5 subunit of GABAA/benzodiazepine receptor by 11C Ro15-4513 using positron emission tomography.
Synapse (New York, N.Y.) 2003;47(3):200-8.
2003: Jun Maeda; Tetsuya Suhara; Takashi Okauchi; Jun'ichi Semba
Different roles of group I and group II metabotropic glutamate receptors on phencyclidine-induced dopamine release in the rat prefrontal cortex.
Neuroscience letters 2003;336(3):171-4.
2002: Terushi Haradahira; Jun Maeda; Takashi Okauchi; Ming-Rong Zhang; Junko Hojo; Takayo Kida; Takuya Arai; Fumihiko Yamamoto; Shigeki Sasaki; Minoru Maeda; Kazutoshi Suzuki; Tetsuya Suhara
Synthesis, in vitro and in vivo pharmacology of a C-11 labeled analog of CP-101,606, (+/-)threo-1-(4-hydroxyphenyl)-2-[4-hydroxy-4-(p-[11C]methoxyphenyl)piperidino]-1-propanol, as a PET tracer for NR2B subunit-containing NMDA receptors.
Nuclear medicine and biology 2002;29(5):517-25.
2002: Ming-Rong Zhang; Terushi Haradahira; Jun Maeda; Takashi Okauchi; Kouichi Kawabe; Takayo Kida; Shigeru Obayashi; Kazutoshi Suzuki; Tetsuya Suhara
Synthesis and evaluation of 3-(4-chlorobenzyl)-8-[11C]methoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one: a PET tracer for imaging sigma(1) receptors.
Nuclear medicine and biology 2002;29(4):469-76.
2002: Tetsuya Suhara; Takashi Okauchi; Yasuhiko Sudo; Akihiro Takano; Kouichi Kawabe; Jun Maeda; Shitij Kapur
Clozapine can induce high dopamine D(2) receptor occupancy in vivo.
Psychopharmacology 2002;160(1):107-12.
2002: Ming-Rong Zhang; Terushi Haradahira; Jun Maeda; Takashi Okauchi; Kouichi Kawabe; Junko Noguchi; Takayo Kida; Kazutoshi Suzuki; Tetsuya Suhara
Syntheses and pharmacological evaluation of two potent antagonists for dopamine D4 receptors: [11C]YM-50001 and N-[2-[4-(4-Chlorophenyl)-piperizin-1-yl]ethyl]-3-[11C]methoxybenzamide.
Nuclear medicine and biology 2002;29(2):233-41.
2002: Terushi Haradahira; Takashi Okauchi; Jun Maeda; Ming-Rong Zhang; Takayo Kida; Kouichi Kawabe; Masayoshi Mishina; Yasuyoshi Watanabe; Kazutoshi Suzuki; Tetsuya Suhara
A positron-emitter labeled glycine(B) site antagonist, [(11)C]L-703,717, preferentially binds to a cerebellar NMDA receptor subtype consisting of GluR epsilon3 subunit in vivo, but not in vitro.
Synapse (New York, N.Y.) 2002;43(2):131-3.
2001: Shigeru Obayashi; Tetsuya Suhara; Kouichi Kawabe; Takashi Okauchi; Jun Maeda; Yoshihide Akine; H Onoe; Atsushi Iriki
Functional brain mapping of monkey tool use.
NeuroImage 2001;14(4):853-61.
2001: Takashi Okauchi; Tetsuya Suhara; Jun Maeda; Kouichi Kawabe; Shigeru Obayashi; Kazutoshi Suzuki
Effect of endogenous dopamine on endogenous dopamine on extrastriated [11C]FLB 457 binding measured by PET.
Synapse (New York, N.Y.) 2001;41(2):87-95.
2001: Junji Ichikawa; M Fujiwara; S Miyazaki; M Ikemoto; Takashi Okauchi; T Minami
Regioselective nucleophilic additions to cross-conjugated dienone system bearing beta-fluorine: a versatile approach to highly substituted 2-cyclopentenones.
Organic letters 2001;3(15):2345-8.
2001: Jun Maeda; Tetsuya Suhara; M Ogawa; Takashi Okauchi; K Kawabe; Ming-Rong Zhang; Jun'ichi Semba; K Suzuki
In vivo binding properties of [carbonyl-11C]WAY-100635: effect of endogenous serotonin.
Synapse (New York, N.Y.) 2001;40(2):122-9.
2001: Shigeki Sasaki; T Kanda; N Ishibashi; Fumihiko Yamamoto; Terushi Haradahira; Takashi Okauchi; J Meda; K Suzuki; Minoru Maeda
4,5,9,10-Tetrahydro-1,4-ethanobenz[b]quinolizine as a prodrug for its quinolizinium cation as a ligand to the open state of the TCP-binding site of NMDA receptors.
Bioorganic & medicinal chemistry letters 2001;11(4):519-21.
2001: Terushi Haradahira; Ming-Rong Zhang; Jun Maeda; Takashi Okauchi; Takayo Kida; Kouichi Kawabe; S Sasaki; Tetsuya Suhara; Kazutoshi Suzuki
A prodrug of NMDA/glycine site antagonist, L-703,717, with improved BBB permeability: 4-acetoxy derivative and its positron-emitter labeled analog.
Chemical & pharmaceutical bulletin 2001;49(2):147-50.
2000: Terushi Haradahira; M Zhang; Jun Maeda; Takashi Okauchi; Kouichi Kawabe; Takayo Kida; Kazutoshi Suzuki; T Suhara1
A strategy for increasing the brain uptake of a radioligand in animals: use of a drug that inhibits plasma protein binding.
Nuclear medicine and biology 2000;27(4):357-60.
1999: Yasuhiko Sudo; Tetsuya Suhara; Kazutoshi Suzuki; Yoshiro Okubo; Kyosan Yoshikawa; S Uchida; T Sassa; Takashi Okauchi; Y Sasaki; M Matsushita
Muscarinic receptor occupancy by biperiden in living human brain.
Life sciences 1999;64(8):PL99-104.
1998: Yasuhiko Sudo; Tetsuya Suhara; Y Honda; T Nakajima; Yoshiro Okubo; Kazutoshi Suzuki; Y Nakashima; Kyosan Yoshikawa; Takashi Okauchi; Y Sasaki; M Matsushita
Muscarinic cholinergic receptors in human narcolepsy: a PET study.
Neurology 1998;51(5):1297-302.