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Hiroaki Okazaki

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Keisuke Ohta; Motohiro Sekiya; Hiroshi Uozaki; Masaki Igarashi; Satoru Takase; Masayoshi Kumagai; Masakatsu Takanashi; Yoshinori Takeuchi; Yoshihiko Izumida; Midori Kubota; Makiko Nishi; Hiroaki Okazaki; Yoko Iizuka; Naoya Yahagi; Hiroaki Yagyu; Masashi Fukayama; Takashi Kadowaki; Ken Ohashi; Shun Ishibashi; Jun-ichi Osuga
Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.
Motohiro Sekiya; Jun-ichi Osuga; Masaki Igarashi; Hiroaki Okazaki; Shun Ishibashi
The role of neutral cholesterol ester hydrolysis in macrophage foam cells.
Masaki Igarashi; Jun-ichi Osuga; Masashi Isshiki; Motohiro Sekiya; Hiroaki Okazaki; Satoru Takase; Mikio Takanashi; Keisuke Ohta; Masayoshi Kumagai; Makiko Nishi; Toshiro Fujita; Ryozo Nagai; Takashi Kadowaki; Shun Ishibashi
Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence.

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All Publications

2011: Keisuke Ohta; Motohiro Sekiya; Hiroshi Uozaki; Masaki Igarashi; Satoru Takase; Masayoshi Kumagai; Masakatsu Takanashi; Yoshinori Takeuchi; Yoshihiko Izumida; Midori Kubota; Makiko Nishi; Hiroaki Okazaki; Yoko Iizuka; Naoya Yahagi; Hiroaki Yagyu; Masashi Fukayama; Takashi Kadowaki; Ken Ohashi; Shun Ishibashi; Jun-ichi Osuga
Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.
Biochemical and biophysical research communications 2011;404(1):254-60.
2011: Motohiro Sekiya; Jun-ichi Osuga; Masaki Igarashi; Hiroaki Okazaki; Shun Ishibashi
The role of neutral cholesterol ester hydrolysis in macrophage foam cells.
Journal of atherosclerosis and thrombosis 2011;18(5):359-64.
2010: Masaki Igarashi; Jun-ichi Osuga; Masashi Isshiki; Motohiro Sekiya; Hiroaki Okazaki; Satoru Takase; Mikio Takanashi; Keisuke Ohta; Masayoshi Kumagai; Makiko Nishi; Toshiro Fujita; Ryozo Nagai; Takashi Kadowaki; Shun Ishibashi
Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence.
Journal of lipid research 2010;51(2):274-85.
2009: Motohiro Sekiya; Naoya Yahagi; Yoshiaki Tamura; Hiroaki Okazaki; Masaki Igarashi; Keisuke Ohta; Mikio Takanashi; Masayoshi Kumagai; Satoru Takase; Makiko Nishi; Yoshinori Takeuchi; Yoshihiko Izumida; Midori Kubota; Ken Ohashi; Yoko Iizuka; Hiroaki Yagyu; Takanari Gotoda; Ryozo Nagai; Hitoshi Shimano; Nobuhiro Yamada; Takashi Kadowaki; Shun Ishibashi; Jun-ichi Osuga
Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.
Biochemical and biophysical research communications 2009;387(3):511-5.
2009: Motohiro Sekiya; Jun-ichi Osuga; Shuichi Nagashima; Taichi Ohshiro; Masaki Igarashi; Hiroaki Okazaki; Manabu Takahashi; Fumiko Tazoe; Taeko Wada; Keisuke Ohta; Mikio Takanashi; Masayoshi Kumagai; Makiko Nishi; Satoru Takase; Naoya Yahagi; Hiroaki Yagyu; Ken Ohashi; Ryozo Nagai; Takashi Kadowaki; Yusuke Furukawa; Shun Ishibashi
Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
Cell metabolism 2009;10(3):219-28.
2008: Hiroaki Okazaki; Masaki Igarashi; Makiko Nishi; Motohiro Sekiya; Makiko Tajima; Satoru Takase; Mikio Takanashi; Keisuke Ohta; Yoshiaki Tamura; Sachiko Okazaki; Naoya Yahagi; Ken Ohashi; Michiyo Amemiya-Kudo; Yoshimi Nakagawa; Ryozo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.
The Journal of biological chemistry 2008;283(48):33357-64.
2008: Fumiko Tazoe; Hiroaki Yagyu; Hiroaki Okazaki; Masaki Igarashi; Kazuhiro Eto; Shu-Ichi Nagashima; Toshihiro Inaba; Hitoshi Shimano; Jun-ichi Osuga; Shun Ishibashi
Induction of ABCA1 by overexpression of hormone-sensitive lipase in macrophages.
Biochemical and biophysical research communications 2008;376(1):111-5.
2008: Motohiro Sekiya; Jun-ichi Osuga; Naoya Yahagi; Hiroaki Okazaki; Yoshiaki Tamura; Masaki Igarashi; Satoru Takase; Kenji Harada; Sachiko Okazaki; Yoko Iizuka; Ken Ohashi; Hiroaki Yagyu; Mitsuyo Okazaki; Takanari Gotoda; Ryozo Nagai; Takashi Kadowaki; Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi
Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis.
Journal of lipid research 2008;49(8):1829-38.
2007: Motohiro Sekiya; Naoya Yahagi; Takashi Matsuzaka; Yoshinori Takeuchi; Yoshimi Nakagawa; Haruka Takahashi; Hiroaki Okazaki; Yoko Iizuka; Ken Ohashi; Takanari Gotoda; Shun Ishibashi; Ryozo Nagai; Tsutomu Yamazaki; Takashi Kadowaki; Nobuhiro Yamada; Jun-ichi Osuga; Hitoshi Shimano
SREBP-1-independent regulation of lipogenic gene expression in adipocytes.
Journal of lipid research 2007;48(7):1581-91.
2006: Hiroaki Okazaki; Fumiko Tazoe; Sachiko Okazaki; Noriko Isoo; Kazuhisa Tsukamoto; Motohiro Sekiya; Naoya Yahagi; Yoko Iizuka; Ken Ohashi; Tetsuya Kitamine; Ryuichi Tozawa; Toshihiro Inaba; Hiroaki Yagyu; Mitsuyo Okazaki; Hitoshi Shimano; Norihito Shibata; Hiroyuki Arai; Ryo-Zo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.
Journal of lipid research 2006;47(9):1950-8.
2006: Hiroaki Okazaki; Masaki Igarashi; Makiko Nishi; Makiko Tajima; Motohiro Sekiya; Sachiko Okazaki; Naoya Yahagi; Ken Ohashi; Kazuhisa Tsukamoto; Michiyo Amemiya-Kudo; Takashi Matsuzaka; Hitoshi Shimano; Nobuhiro Yamada; Junken Aoki; Rei Morikawa; Yasukazu Takanezawa; Hiroyuki Arai; Ryozo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis.
Diabetes 2006;55(7):2091-7.
2005: Yuho Najima; Naoya Yahagi; Yoshinori Takeuchi; Takashi Matsuzaka; Motohiro Sekiya; Yoshimi Nakagawa; Michiyo Amemiya-Kudo; Hiroaki Okazaki; Sachiko Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Takashi Kadowaki; Shun Ishibashi; Nobuhiro Yamada; Jun-ichi Osuga; Hitoshi Shimano
High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.
The Journal of biological chemistry 2005;280(30):27523-32.
2005: Naoya Yahagi; Hitoshi Shimano; Kiyoshi Hasegawa; Ken Ohashi; Takashi Matsuzaka; Yuho Najima; Motohiro Sekiya; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Kenichi Ohashi; Ryozo Nagai; Shun Ishibashi; Takashi Kadowaki; Makuuchi Masatoshi; Shin Ohnishi; Jun-ichi Osuga; Nobuhiro Yamada
Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma.
European journal of cancer (Oxford, England : 1990) 2005;41(9):1316-22.
2004: Yoshiaki Tamura; Jun-ichi Osuga; Hideki Adachi; Ryuichi Tozawa; Yasukazu Takanezawa; Ken Ohashi; Naoya Yahagi; Motohiro Sekiya; Hiroaki Okazaki; Sachiko Tomita; Yoko Iizuka; Hiroyuki Koizumi; Toshihiro Inaba; Hiroaki Yagyu; Nobuo Kamada; Hiroshi Suzuki; Hitoshi Shimano; Takashi Kadowaki; Masafumi Tsujimoto; Hiroyuki Arai; Nobuhiro Yamada; Shun Ishibashi
Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide.
The Journal of biological chemistry 2004;279(30):30938-44.
2004: Naoya Yahagi; Hitoshi Shimano; Takashi Matsuzaka; Motohiro Sekiya; Yuho Najima; Sachiko Okazaki; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Noriyuki Inoue; Yoshimi Nakagawa; Yoshinori Takeuchi; Ken Ohashi; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Takashi Kadowaki; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada
p53 involvement in the pathogenesis of fatty liver disease.
The Journal of biological chemistry 2004;279(20):20571-5.
2004: Hirohito Sone; Hitoshi Shimano; Miao Shu; Masanori Nakakuki; Akimitsu Takahashi; Masakazu Sakai; Yuichiro Sakamoto; Takashi Yokoo; Ken Matsuzaka; Hiroaki Okazaki; Yoshimi Nakagawa; Kaoruko Tada Iida; Hiroaki Suzuki; Hideo Toyoshima; Seikoh Horiuchi; Nobuhiro Yamada
Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages.
Biochemical and biophysical research communications 2004;316(3):790-4.
2004: Motohiro Sekiya; Jun-ichi Osuga; Hiroaki Okazaki; Naoya Yahagi; Kenji Harada; Wen-Jun Shen; Yoshiaki Tamura; Sachiko Tomita; Yoko Iizuka; Ken Ohashi; Mitsuyo Okazaki; Masataka Sata; Ryozo Nagai; Toshiro Fujita; Hitoshi Shimano; Fredric B Kraemer; Nobuhiro Yamada; Shun Ishibashi
Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice.
The Journal of biological chemistry 2004;279(15):15084-90.
2004: Takashi Matsuzaka; Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Sachiko Tomita; Motohiro Sekiya; Alyssa H Hasty; Yoshimi Nakagawa; Hirohito Sone; Hideo Toyoshima; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada
Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice.
Diabetes 2004;53(3):560-9.
2003: Ken Ohashi; Jun-ichi Osuga; Ryuichi Tozawa; Tetsuya Kitamine; Hiroaki Yagyu; Motohiro Sekiya; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Naoya Yahagi; Yoko Iizuka; Kenji Harada; Takanari Gotoda; Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi
Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene.
The Journal of biological chemistry 2003;278(44):42936-41.
2003: Naoya Yahagi; Hitoshi Shimano; Takashi Matsuzaka; Yuho Najima; Motohiro Sekiya; Yoshimi Nakagawa; Tomohiro Ide; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Takanari Gotoda; Ryozo Nagai; Satoshi Kimura; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada
p53 Activation in adipocytes of obese mice.
The Journal of biological chemistry 2003;278(28):25395-400.
2003: Tomohiro Yoshikawa; Tomohiro Ide; Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; Takashi Matsuzaka; Shigeru Yatoh; Tetsuya Kitamine; Hiroaki Okazaki; Yoshiaki Tamura; Motohiro Sekiya; Akimitsu Takahashi; Alyssa H Hasty; Ryuichiro Sato; Hirohito Sone; Jun-ichi Osuga; Shun Ishibashi; Nobuhiro Yamada
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1240-54.
2003: Yoshiaki Tamura; Hideki Adachi; Jun-ichi Osuga; Ken Ohashi; Naoya Yahagi; Motohiro Sekiya; Hiroaki Okazaki; Sachiko Tomita; Yoko Iizuka; Hitoshi Shimano; Ryozo Nagai; Satoshi Kimura; Masafumi Tsujimoto; Shun Ishibashi
FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.
The Journal of biological chemistry 2003;278(15):12613-7.
2002: Hiroaki Okazaki; Jun-ichi Osuga; Yoshiaki Tamura; Naoya Yahagi; Sachiko Tomita; Futoshi Shionoiri; Yoko Iizuka; Ken Ohashi; Kenji Harada; Satoshi Kimura; Takanari Gotoda; Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi
Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.
Diabetes 2002;51(12):3368-75.
2002: Hiroaki Okazaki; Jun-ichi Osuga; Kazuhisa Tsukamoto; Noriko Isoo; Tetsuya Kitamine; Yoshiaki Tamura; Sachiko Tomita; Motohiro Sekiya; Naoya Yahagi; Yoko Iizuka; Ken Ohashi; Kenji Harada; Takanari Gotoda; Hitoshi Shimano; Satoshi Kimura; Ryozo Nagai; Nobuhiro Yamada; Shun Ishibashi
Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.
The Journal of biological chemistry 2002;277(35):31893-9.
2002: Yoshiaki Tamura; Shun Ishibashi; Takanari Gotoda; Junko Yasufuku-Takano; Koji Takano; Keisuke Ueki; Shigeo Yamashita; Yoko Iizuka; Naoya Yahagi; Futoshi Shionoiri; Hiroaki Okazaki; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Hitoshi Shimano; Toshiro Fujita; Nobuhiro Yamada; Satoshi Kimura
A kindred of familial acromegaly without evidence for linkage to MEN-1 locus.
Endocrine journal 2002;49(4):425-31.
2002: Michiyo Amemiya-Kudo; Hitoshi Shimano; Alyssa H Hasty; Naoya Yahagi; Tomohiro Yoshikawa; Takashi Matsuzaka; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Ryuichiro Sato; Satoshi Kimura; Shun Ishibashi; Nobuhiro Yamada
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.
Journal of lipid research 2002;43(8):1220-35.
2002: Takashi Matsuzaka; Hitoshi Shimano; Naoya Yahagi; Tomohiro Yoshikawa; Michiyo Amemiya-Kudo; Alyssa H Hasty; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Akimitsu Takahashi; Shigeru Yato; Hirohito Sone; Shun Ishibashi; Nobuhiro Yamada
Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.
Journal of lipid research 2002;43(6):911-20.
2002: Naoya Yahagi; Hitoshi Shimano; Alyssa H Hasty; Takashi Matsuzaka; Tomohiro Ide; Tomohiro Yoshikawa; Michiyo Amemiya-Kudo; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.
The Journal of biological chemistry 2002;277(22):19353-7.
2002: Tomohiro Yoshikawa; Hitoshi Shimano; Naoya Yahagi; Tomohiro Ide; Michiyo Amemiya-Kudo; Takashi Matsuzaka; Masanori Nakakuki; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Akimitsu Takahashi; Hirohito Sone; Jun-ichi Osuga Ji; Takanari Gotoda; Shun Ishibashi; Nobuhiro Yamada
Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements.
The Journal of biological chemistry 2002;277(3):1705-11.
2002: Takashi Matsuzaka; Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; Tomohiro Yoshikawa; Alyssa H Hasty; Yoshiaki Tamura; Jun-ichi Osuga; Hiroaki Okazaki; Yoko Iizuka; Akimitsu Takahashi; Hirohito Sone; Takanari Gotoda; Shun Ishibashi; Nobuhiro Yamada
Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha.
Journal of lipid research 2002;43(1):107-14.
2001: Alyssa H Hasty; Hitoshi Shimano; Jun-ichi Osuga; I Namatame; Akimitsu Takahashi; Naoya Yahagi; S Perrey; Yoko Iizuka; Yoshiaki Tamura; Michiyo Amemiya-Kudo; Tomohiro Yoshikawa; Hiroaki Okazaki; Ken Ohashi; Kenji Harada; Takashi Matsuzaka; Hirohito Sone; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor.
The Journal of biological chemistry 2001;276(40):37402-8.
2001: Tomohiro Yoshikawa; Hitoshi Shimano; Michiyo Amemiya-Kudo; Naoya Yahagi; Alyssa H Hasty; Takashi Matsuzaka; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Satoshi Kimura; Shun Ishibashi; Nobuhiro Yamada
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter.
Molecular and cellular biology 2001;21(9):2991-3000.
2001: Ryuichi Tozawa; Shun Ishibashi; Jun-ichi Osuga; Kazuhiko Yamamoto; Hiroaki Yagyu; Ken Ohashi; Yoshiaki Tamura; Naoya Yahagi; Yoko Iizuka; Hiroaki Okazaki; Kenji Harada; Takanari Gotoda; Hitoshi Shimano; Satoshi Kimura; Ryozo Nagai; Nobuhiro Yamada
Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its obligate requirement for the stable expression of oligomeric receptor.
The Journal of biological chemistry 2001;276(16):12624-8.
2001: Z Chen; Shun Ishibashi; S Perrey; Takanari Gotoda; Tetsuya Kitamine; Yoshiaki Tamura; Hiroaki Okazaki; Naoya Yahagi; Yoko Iizuka; Futoshi Shionoiri; Ken Ohashi; Kenji Harada; Hitoshi Shimano; Ryozo Nagai; Nobuhiro Yamada
Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(3):372-7.
2000: Michiyo Amemiya-Kudo; Hitoshi Shimano; Tomohiro Yoshikawa; Naoya Yahagi; Alyssa H Hasty; Hiroaki Okazaki; Yoshiaki Tamura; Futoshi Shionoiri; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Ryuichiro Sato; Satoshi Kimura; Shun Ishibashi; Nobuhiro Yamada
Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene.
The Journal of biological chemistry 2000;275(40):31078-85.
2000: Alyssa H Hasty; Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; S Perrey; Tomohiro Yoshikawa; Jun-ichi Osuga; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Futoshi Shionoiri; Ken Ohashi; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.
The Journal of biological chemistry 2000;275(40):31069-77.
2000: Hiroaki Yagyu; Tetsuya Kitamine; Jun-ichi Osuga; Ryuichi Tozawa; Z Chen; Y Kaji; Toru Oka; S Perrey; Yoshiaki Tamura; Ken Ohashi; Hiroaki Okazaki; Naoya Yahagi; Futoshi Shionoiri; Yoko Iizuka; Kenji Harada; Hitoshi Shimano; H Yamashita; Takanari Gotoda; Nobuhiro Yamada; Shun Ishibashi
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia.
The Journal of biological chemistry 2000;275(28):21324-30.
1999: Naoya Yahagi; Hitoshi Shimano; Alyssa H Hasty; Michiyo Amemiya-Kudo; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Futoshi Shionoiri; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.
The Journal of biological chemistry 1999;274(50):35840-4.
1999: Koichi Gonda; H Okamoto; Noriko Takuwa; Yutaka Yatomi; Hiroaki Okazaki; T Sakurai; Satoshi Kimura; R Sillard; K Harii; Yoh Takuwa
The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways.
The Biochemical journal 1999;337 ( Pt 1)():67-75.
1998: H Okamoto; Noriko Takuwa; Koichi Gonda; Hiroaki Okazaki; K Chang; Yutaka Yatomi; H Shigematsu; Yoh Takuwa
EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition.
The Journal of biological chemistry 1998;273(42):27104-10.