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Kazushi Okazaki

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Yasuki Kitamura; Takashi Umemura; Kazushi Okazaki; Keita Kanki; Takayoshi Imazawa; Toshiaki Masegi; Akiyoshi Nishikawa; Masao Hirose
Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine.
Yasuki Kitamura; Megumi Yamagishi; Kazushi Okazaki; Fumio Furukawa; Takayoshi Imazawa; Akiyoshi Nishikawa; Masao Hirose
Lack of enhancing effects of sodium nitrite on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.
Kazushi Okazaki; Yuji Ishii; Yasuki Kitamura; Satoshi Maruyama; Takashi Umemura; Makoto Miyauchi; Megumi Yamagishi; Takayoshi Imazawa; Akiyoshi Nishikawa; Yoshihiro Yoshimura; Hiroyuki Nakazawa; Masao Hirose
Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine: possible contribution of nitric oxide-associated oxidative DNA damage.

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2006: Yasuki Kitamura; Takashi Umemura; Kazushi Okazaki; Keita Kanki; Takayoshi Imazawa; Toshiaki Masegi; Akiyoshi Nishikawa; Masao Hirose
Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine.
International journal of cancer. Journal international du cancer 2006;118(10):2399-404.
2006: Yasuki Kitamura; Megumi Yamagishi; Kazushi Okazaki; Fumio Furukawa; Takayoshi Imazawa; Akiyoshi Nishikawa; Masao Hirose
Lack of enhancing effects of sodium nitrite on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.
Cancer letters 2006;235(1):69-74.
2006: Kazushi Okazaki; Yuji Ishii; Yasuki Kitamura; Satoshi Maruyama; Takashi Umemura; Makoto Miyauchi; Megumi Yamagishi; Takayoshi Imazawa; Akiyoshi Nishikawa; Yoshihiro Yoshimura; Hiroyuki Nakazawa; Masao Hirose
Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine: possible contribution of nitric oxide-associated oxidative DNA damage.
Cancer science 2006;97(3):175-82.
2006: Yasuki Kitamura; Megumi Yamagishi; Kazushi Okazaki; Takashi Umemura; Takayoshi Imazawa; Akiyoshi Nishikawa; W Matsumoto; Masao Hirose
Lack of chemopreventive effects of alpha-eleostearic acid on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary and colon carcinogenesis in female Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(2):271-7.
2006: Akiyoshi Nishikawa; Kimie Sai; Kazushi Okazaki; Hwa-Young Son; Keita Kanki; Madoka Nakajima; Naohide Kinae; Takehiko Nohmi; James E Trosko; Tohru Inoue; Masao Hirose
MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells.
Environmental and molecular mutagenesis 2006;47(1):48-55.
2005: Akiyoshi Nishikawa; Takako Ikeda; Hwa-Young Son; Kazushi Okazaki; Takayoshi Imazawa; Takashi Umemura; Shuichi Kimura; Masao Hirose
Pronounced synergistic promotion of N-bis(2-hydroxypropyl)nitrosamine-initiated thyroid tumorigenesis in rats treated with excess soybean and iodine-deficient diets.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):258-63.
2004: Hwa-Young Son; Akiyoshi Nishikawa; Kazushi Okazaki; Yasuki Kitamura; Keita Kanki; Kyong-Youl Lee; Takashi Umemura; Masao Hirose
Specificity of co-promoting effects of caffeine on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Toxicologic pathology 2004;32(3):338-44.
2004: Takashi Umemura; Yasuki Kitamura; Keita Kanki; Satoshi Maruyama; Kazushi Okazaki; Takayoshi Imazawa; Tetsuji Nishimura; Ryuichi Hasegawa; Akiyoshi Nishikawa; Masao Hirose
Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate.
Cancer science 2004;95(5):393-8.
2003: Hwa-Young Son; Akiyoshi Nishikawa; Kazushi Okazaki; Kyong- Youl Lee; Takayoshi Imazawa; Masao Hirose
Lack of modifying effects of atrazine and/or tamoxifen on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(12):1811-6.
2003: Kazushi Okazaki; Takashi Umemura; Takayoshi Imazawa; Akiyoshi Nishikawa; Toshiaki Masegi; Masao Hirose
Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl)nitrosamine in rats after initiation.
Cancer science 2003;94(11):948-52.
2003: Yasuki Kitamura; Akiyoshi Nishikawa; Fumio Furukawa; Hideaki Nakamura; Kazushi Okazaki; Takashi Umemura; Takayoshi Imazawa; Masao Hirose
A subchronic toxicity study of shea nut color in Wistar rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(11):1537-42.
2003: Yasuki Kitamura; Megumi Yamagishi; Kazushi Okazaki; Hwa-Young Son; Takayoshi Imazawa; Akiyoshi Nishikawa; Toshio Iwata; Yoshie Yamauchi; Masaaki Kasai; Kentaro Tsutsumi; Masao Hirose
Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.
Cancer letters 2003;200(2):133-9.
2003: Fumio Furukawa; Akiyoshi Nishikawa; In-Seon Lee; Keita Kanki; Takashi Umemura; Kazushi Okazaki; Toshihiko Kawamori; Keiji Wakabayashi; Masao Hirose
A cyclooxygenase-2 inhibitor, nimesulide, inhibits postinitiation phase of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters.
International journal of cancer. Journal international du cancer 2003;104(3):269-73.
2003: Hwa-Young Son; Akiyoshi Nishikawa; Keita Kanki; Kazushi Okazaki; Yasuki Kitamura; Kyong-Youl Lee; Takashi Umemura; Masao Hirose
Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer science 2003;94(4):334-7.
2003: Megumi Yamagishi; Midori Natsume; Naomi Osakabe; Kazushi Okazaki; Fumio Furukawa; Takayoshi Imazawa; Akiyoshi Nishikawa; Masao Hirose
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
Cancer letters 2003;191(1):49-57.
2003: Hwa-Young Son; Akiyoshi Nishikawa; Kazushi Okazaki; Keita Kanki; Megumi Yamagishi; Takayoshi Imazawa; Takashi Umemura; Masao Hirose
Prolonged effects of beta-estradiol 3-benzoate on thyroid tumorigenesis in gonadectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer letters 2003;190(1):21-9.
2002: Kazushi Okazaki; Shuzo Okazaki; Hideaki Nakamura; Yasuki Kitamura; Kazuhisa Hatayama; Sachiko Wakabayashi; Toshiharu Tsuda; Tomoyoshi Katsumata; Akiyoshi Nishikawa; Masao Hirose
A repeated 28-day oral dose toxicity study of genistein in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals.
Archives of toxicology 2002;76(10):553-9.
2002: Hideaki Nakamura; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Makoto Miyauchi; Kazushi Okazaki; Takayoshi Imazawa; Koji Uchida; Masao Hirose
Enhancing effects of oltipraz on the development of spontaneous hepatic lesions in LEC rats.
Toxicologic pathology 2002;30(2):173-7.
2002: Kazushi Okazaki; Megumi Yamagishi; Hwa-Young Son; Takayoshi Imazawa; Fumio Furukawa; Hideaki Nakamura; Akiyoshi Nishikawa; Toshiaki Masegi; Masao Hirose
Simultaneous treatment with benzyl isothiocyanate, a strong bladder promoter, inhibits rat urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Nutrition and cancer 2002;42(2):211-6.
2002: Kazushi Okazaki; Takayoshi Imazawa; Hideaki Nakamura; Fumio Furukawa; Akiyoshi Nishikawa; Masao Hirose
A repeated 28-day oral dose toxicity study of 17alpha-methyltestosterone in rats, based on the 'enhanced OECD Test Guideline 407' for screening the endocrine-disrupting chemicals.
Archives of toxicology 2002;75(11-12):635-42.
2002: Akiyoshi Nishikawa; Fumio Furukawa; Makoto Miyauchi; Hwa-Young Son; Kazushi Okazaki; Akihiro Koide; Yukio Mori; Masao Hirose
Enhancement by cigarette smoke exposure of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis in close association with elevation of hepatic CYP1A2.
Japanese journal of cancer research : Gann 2002;93(1):24-31.