Regis O'Keefe

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Anatomy

Living Beings

Chemicals & Drugs

Physiology

Disorders

Osteolysis

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Publications

TOP 3
Frisch Benjamin J; Porter Rebecca L; Gigliotti Benjamin J; Olm-Shipman Adam J; Weber Jonathan M; O'Keefe Regis J; Jordan Craig T; Calvi Laura M
In vivo prostaglandin E(2) treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells.
Yan Ying; Tang Dezhi; Chen Mo; Huang Jian; Xie Rong; Jonason Jennifer H; Tan Xiaohong; Hou Wei; Reynolds David; Hsu Wei; Harris Stephen E; Puzas J Edward; Awad Hani; O'Keefe Regis J; Boyce Brendan F; Chen Di
Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice.
Darowish Michael; Rahman Ra'Kerry; Li Ping; Bukata Susan V; Gelinas Jill; Huang Willis; Flick Lisa M; Schwarz Edward M; O'Keefe Regis J
Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation.

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All Publications

2009: Frisch Benjamin J; Porter Rebecca L; Gigliotti Benjamin J; Olm-Shipman Adam J; Weber Jonathan M; O'Keefe Regis J; Jordan Craig T; Calvi Laura M
In vivo prostaglandin E(2) treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells.
Blood 2009;114(19):4054-63.
2009: Yan Ying; Tang Dezhi; Chen Mo; Huang Jian; Xie Rong; Jonason Jennifer H; Tan Xiaohong; Hou Wei; Reynolds David; Hsu Wei; Harris Stephen E; Puzas J Edward; Awad Hani; O'Keefe Regis J; Boyce Brendan F; Chen Di
Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice.
Journal of cell science 2009;122(Pt 19):3566-78.
2009: Darowish Michael; Rahman Ra'Kerry; Li Ping; Bukata Susan V; Gelinas Jill; Huang Willis; Flick Lisa M; Schwarz Edward M; O'Keefe Regis J
Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation.
Bone 2009;45(4):661-8.
2009: Tsutsumi Ryosuke; Xie Chao; Wei Xiaochao; Zhang Minjie; Zhang Xinping; Flick Lisa M; Schwarz Edward M; O'Keefe Regis J
PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(10):1753-62.
2009: Xie Chao; Liang Bojian; Xue Ming; Lin Angela S P; Loiselle Alayna; Schwarz Edward M; Guldberg Robert E; O'Keefe Regis J; Zhang Xinping
Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4.
The American journal of pathology 2009;175(2):772-85.
2009: Wei Xiaochao; Zhang Xinping; Flick Lisa M; Drissi Hicham; Schwarz Edward M; O'Keefe Regis J
Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway.
American journal of physiology. Cell physiology 2009;297(2):C310-20.
2009: Wu Qiuqian; Huang Jason H; Sampson Erik R; Kim Kyung-O K; Zuscik Michael J; O'Keefe Regis J; Chen Di; Rosier Randy N
Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.
Experimental cell research 2009;315(14):2386-98.
2009: Crane Daniel P; Gromov Kirill; Li Dan; Søballe Kjeld; Wahnes Christian; Büchner Hubert; Hilton Matthew J; O'Keefe Regis J; Murray Clinton K; Schwarz Edward M
Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2009;27(8):1008-15.
2009: Taylor Douglas K; Meganck Jeffrey A; Terkhorn Shawn; Rajani Rajiv; Naik Amish; O'Keefe Regis J; Goldstein Steven A; Hankenson Kurt D
Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(6):1043-54.
2009: Loiselle Alayna E; Bragdon Gwynne A; Jacobson Justin A; Hasslund Sys; Cortes Zenia E; Schwarz Edward M; Mitten David J; Awad Hani A; O'Keefe Regis J
Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2009;27(6):833-40.
2009: Clark Christine A; Li Tian-Fang; Kim Kyung-Ok; Drissi Hicham; Zuscik Michael J; Zhang Xinping; O'Keefe Regis J
Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2009;27(6):785-92.
2009: Reynolds David G; Shaikh Saad; Papuga Mark Owen; Lerner Amy L; O'Keefe Regis J; Schwarz Edward M; Awad Hani A
muCT-based measurement of cortical bone graft-to-host union.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(5):899-907.
2009: Naik Amish A; Xie Chao; Zuscik Michael J; Kingsley Paul; Schwarz Edward M; Awad Hani; Guldberg Robert; Drissi Hicham; Puzas J Edward; Boyce Brendan; Zhang Xinping; O'Keefe Regis J
Reduced COX-2 expression in aged mice is associated with impaired fracture healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(2):251-64.
2008: Xie Chao; Ming Xue; Wang Qun; Schwarz Edward M; Guldberg Robert E; O'Keefe Regis J; Zhang Xinping
COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing.
Bone 2008;43(6):1075-83.
2008: Wu Qiuqian; Kim Kyung-Ok; Sampson Erik R; Chen Di; Awad Hani; O'Brien Todd; Puzas J Edward; Drissi Hicham; Schwarz Edward M; O'Keefe Regis J; Zuscik Michael J; Rosier Randy N
Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.
Arthritis and rheumatism 2008;58(10):3132-44.
2008: Tsutsumi Ryosuke; Hock Colleen; Bechtold C Dustin; Proulx Steven T; Bukata Susan V; Ito Hiromu; Awad Hani A; Nakamura Takashi; O'Keefe Regis J; Schwarz Edward M
Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008;26(10):1340-6.
2008: Kaback Lee A; Soung Do Y; Naik Amish; Geneau Graziello; Schwarz Edward M; Rosier Randy N; O'Keefe Regis J; Drissi Hicham
Teriparatide (1-34 human PTH) regulation of osterix during fracture repair.
Journal of cellular biochemistry 2008;105(1):219-26.
2008: Zhang Xinping; Awad Hani A; O'Keefe Regis J; Guldberg Robert E; Schwarz Edward M
A perspective: engineering periosteum for structural bone graft healing.
Clinical orthopaedics and related research 2008;466(8):1777-87.
2008: Zhu Mei; Chen Mo; Zuscik Michael; Wu Qiuqian; Wang Yong-Jun; Rosier Randy N; O'Keefe Regis J; Chen Di
Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction.
Arthritis and rheumatism 2008;58(7):2053-64.
2008: Eliseev R A; Dong Y-F; Sampson E; Zuscik M J; Schwarz E M; O'Keefe R J; Rosier R N; Drissi M H
Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis.
Oncogene 2008;27(25):3605-14.
2008: Hasslund Sys; Jacobson Justin A; Dadali Tulin; Basile Patrick; Ulrich-Vinther Michael; Søballe Kjeld; Schwarz Edward M; O'Keefe Regis J; Mitten David J; Awad Hani A
Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008;26(6):824-33.
2008: Chen Mo; Zhu Mei; Awad Hani; Li Tian-Fang; Sheu Tzong-Jen; Boyce Brendan F; Chen Di; O'Keefe Regis J
Inhibition of beta-catenin signaling causes defects in postnatal cartilage development.
Journal of cell science 2008;121(Pt 9):1455-65.
2008: Wu Qiuqian; Wang Meina; Zuscik Michael J; Chen Di; O'Keefe Regis J; Rosier Randy N
Regulation of embryonic endochondral ossification by Smurf2.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008;26(5):704-12.
2008: Wu Qiuqian; Chen Di; Zuscik Michael J; O'Keefe Regis J; Rosier Randy N
Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(4):552-63.
2008: Basile Patrick; Dadali Tulin; Jacobson Justin; Hasslund Sys; Ulrich-Vinther Michael; Søballe Kjeld; Nishio Yasuhiko; Drissi M Hicham; Langstein Howard N; Mitten David J; O'Keefe Regis J; Schwarz Edward M; Awad Hani A
Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):466-73.
2008: Xie Chao; Xue Ming; Wang Qun; Schwarz Edward M; O'Keefe Regis J; Zhang Xinping
Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation.
The Journal of bone and joint surgery. American volume 2008;90 Suppl 1():9-13.
2008: Zuscik Michael J; Hilton Matthew J; Zhang Xinping; Chen Di; O'Keefe Regis J
Regulation of chondrogenesis and chondrocyte differentiation by stress.
The Journal of clinical investigation 2008;118(2):429-38.
2008: Li Dan; Gromov Kirill; Søballe Kjeld; Puzas J Edward; O'Keefe Regis J; Awad Hani; Drissi Hicham; Schwarz Edward M
Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008;26(1):96-105.
2008: Kaback Lee A; Soung Do Y; Naik Amish; Smith Nathan; Schwarz Edward M; O'Keefe Regis J; Drissi Hicham
Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification.
Journal of cellular physiology 2008;214(1):173-82.
2007: Dao Debbie Y; Yang Xue; Chen Di; Zuscik Michael; O'Keefe Regis J
Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways.
Annals of the New York Academy of Sciences 2007;1116():82-99.
2007: Dong Yu-Feng; Soung Do Y; Chang Yoon; Enomoto-Iwamoto Motomi; Paris Mark; O'Keefe Regis J; Schwarz Edward M; Drissi Hicham
Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner.
Molecular endocrinology (Baltimore, Md.) 2007;21(11):2805-20.
2007: Zuscik Michael J; Ma Lin; Buckley Taylor; Puzas J Edward; Drissi Hicham; Schwarz Edward M; O'Keefe Regis J
Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations.
Environmental health perspectives 2007;115(9):1276-82.
2007: Awad Hani A; Zhang Xinping; Reynolds David G; Guldberg Robert E; O'Keefe Regis J; Schwarz Edward M
Recent advances in gene delivery for structural bone allografts.
Tissue engineering 2007;13(8):1973-85.
2007: Soung Do Y; Dong Yufeng; Wang YongJun; Zuscik Michael J; Schwarz Edward M; O'Keefe Regis J; Drissi Hicham
Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(8):1260-70.
2007: Wang Qing; Wei Xiaochao; Zhu Tianhui; Zhang Ming; Shen Run; Xing Lianping; O'Keefe Regis J; Chen Di
Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2.
The Journal of biological chemistry 2007;282(14):10742-8.
2007: Xie Chao; Reynolds David; Awad Hani; Rubery Paul T; Pelled Gadi; Gazit Dan; Guldberg Robert E; Schwarz Edward M; O'Keefe Regis J; Zhang Xinping
Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering.
Tissue engineering 2007;13(3):435-45.
2007: Chen Mo; Lichtler Alexander C; Sheu Tzong-Jen; Xie Chao; Zhang Xinping; O'Keefe Regis J; Chen Di
Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase.
Genesis (New York, N.Y. : 2000) 2007;45(1):44-50.
2007: Reynolds David G; Hock Colleen; Shaikh Saad; Jacobson Justin; Zhang Xinping; Rubery Paul T; Beck Christopher A; O'keefe Regis J; Lerner Amy L; Schwarz Edward M; Awad Hani A
Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts.
Journal of biomechanics 2007;40(14):3178-86.
2006: Baumhauer Judith F; O'Keefe Regis J; Schon Lew C; Pinzur Michael S
Cytokine-induced osteoclastic bone resorption in charcot arthropathy: an immunohistochemical study.
Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society 2006;27(10):797-800.
2006: Robertson Galen; Xie Chao; Chen Di; Awad Hani; Schwarz Edward M; O'Keefe Regis J; Guldberg Robert E; Zhang Xinping
Alteration of femoral bone morphology and density in COX-2-/- mice.
Bone 2006;39(4):767-72.
2006: Li Tian-Fang; Chen Di; Wu Qiuqian; Chen Mo; Sheu Tzong-Jen; Schwarz Edward M; Drissi Hicham; Zuscik Michael; O'Keefe Regis J
Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes.
The Journal of biological chemistry 2006;281(30):21296-304.
2006: Dong Yu-Feng; Soung Do Y; Schwarz Edward M; O'Keefe Regis J; Drissi Hicham
Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.
Journal of cellular physiology 2006;208(1):77-86.
2006: Shen Run; Wang Xiumei; Drissi Hicham; Liu Fang; O'Keefe Regis J; Chen Di
Cyclin D1-cdk4 induce runx2 ubiquitination and degradation.
The Journal of biological chemistry 2006;281(24):16347-53.
2006: Nishio Yasuhiko; Dong Yufeng; Paris Mark; O'Keefe Regis J; Schwarz Edward M; Drissi Hicham
Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene.
Gene 2006;372():62-70.
2006: O'Keefe Regis J; Tiyapatanaputi Prarop; Xie Chao; Li Tian Fang; Clark Chris; Zuscik Micheal J; Chen Di; Drissi Hicham; Schwarz Edward; Zhang Xinping
COX-2 has a critical role during incorporation of structural bone allografts.
Annals of the New York Academy of Sciences 2006;1068():532-42.
2006: Schwarz Edward M; Looney R John; Drissi M Hicham; O'Keefe Regis J; Boyce Brendan F; Xing Lianping; Ritchlin Christopher T
Autoimmunity and bone.
Annals of the New York Academy of Sciences 2006;1068():275-83.
2006: Maloney Michael D; Goater J Jeffrey; Parsons Richard; Ito Hiromu; O'Keefe Regis J; Rubery Paul T; Drissi M Hicham; Schwarz Edward M
Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects.
The Journal of bone and joint surgery. American volume 2006;88(4):753-61.
2006: Shen Run; Chen Mo; Wang Yong-Jun; Kaneki Hiroyuki; Xing Lianping; O'keefe Regis J; Chen Di
Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation.
The Journal of biological chemistry 2006;281(6):3569-76.
2006: Li Tian-Fang; Darowish Michael; Zuscik Michael J; Chen Di; Schwarz Edward M; Rosier Randy N; Drissi Hicham; O'Keefe Regis J
Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(1):4-16.
2006: Looney R John; Schwarz Edward M; Boyd Allen; O'Keefe Regis J
Periprosthetic osteolysis: an immunologist's update.
Current opinion in rheumatology 2006;18(1):80-7.
2006: Eliseev Roman A; Schwarz Edward M; Zuscik Michael J; O'Keefe Regis J; Drissi Hicham; Rosier Randy N
Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB.
Experimental cell research 2006;312(1):40-50.
2005: Andela Valentine B; Schwarz Edward M; O'Keefe Regis J; Puzas Edward J; Rosenblatt Joseph D; Rosier Randy N
A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival.
FEBS letters 2005;579(30):6814-20.
2005: Zhang Xinping; Xie Chao; Lin Angela S P; Ito Hiromu; Awad Hani; Lieberman Jay R; Rubery Paul T; Schwarz Edward M; O'Keefe Regis J; Guldberg Robert E
Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(12):2124-37.
2005: Eliseev Roman A; Zuscik Michael J; Schwarz Edward M; O'Keefe Regis J; Drissi Hicham; Rosier Randy N
Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase.
Journal of cellular biochemistry 2005;96(6):1262-73.
2005: Soloviev Alexander; Schwarz Edward M; Darowish Michael; O'Keefe Regis J
Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: a role for free radicals, NFkappaB, and TNFalpha.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2005;23(6):1258-65.
2005: O'Keefe R J
Summary--Cell therapies for orthopedic applications.
Journal of musculoskeletal & neuronal interactions 2005;5(4):367-8.
2005: Zhang X; Naik A; Xie C; Reynolds D; Palmer J; Lin A; Awad H; Guldberg R; Schwarz E; O'Keefe R
Periosteal stem cells are essential for bone revitalization and repair.
Journal of musculoskeletal & neuronal interactions 2005;5(4):360-2.
2005: Boyce Brendan F; Li Ping; Yao Zhenqiang; Zhang Qian; Badell I Raul; Schwarz Edward M; O'Keefe Regis J; Xing Lianping
TNF-alpha and pathologic bone resorption.
The Keio journal of medicine 2005;54(3):127-31.
2005: Voloshin Ilya; Gelinas Jill; Maloney Michael D; O'Keefe Regis J; Bigliani Louis U; Blaine Theodore A
Proinflammatory cytokines and metalloproteases are expressed in the subacromial bursa in patients with rotator cuff disease.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2005;21(9):1076.
2005: Wang YongJun; Belflower Ruth M; Dong Yu-Feng; Schwarz Edward M; O'Keefe Regis J; Drissi Hicham
Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(9):1624-36.
2005: Koefoed Mette; Ito Hiromu; Gromov Kirill; Reynolds David G; Awad Hani A; Rubery Paul T; Ulrich-Vinther Michael; Soballe Kjeld; Guldberg Robert E; Lin Angela S P; O'Keefe Regis J; Zhang Xinping; Schwarz Edward M
Biological effects of rAAV-caAlk2 coating on structural allograft healing.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(2):212-8.
2005: Dong Yufeng; Drissi Hicham; Chen Mo; Chen Di; Zuscik Michael J; Schwarz Edward M; O'Keefe Regis J
Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta.
Journal of cellular biochemistry 2005;95(5):1057-68.
2005: Wei Xiaochao; Zhang Xinping; Zuscik Michael J; Drissi M Hicham; Schwarz Edward M; O'Keefe Regis J
Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(7):1136-48.
2005: Carmouche Jonathan J; Puzas J Edward; Zhang Xinping; Tiyapatanaputi Prarop; Cory-Slechta Deborah A; Gelein Robert; Zuscik Michael; Rosier Randy N; Boyce Brendan F; O'Keefe Regis J; Schwarz Edward M
Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency.
Environmental health perspectives 2005;113(6):749-55.
2005: Gordon Andrew H; O'Keefe Regis J; Schwarz Edward M; Rosier Randy N; Puzas J Edward
Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone.
Cancer research 2005;65(8):3209-17.
2005: Smith Nathan; Dong Yufeng; Lian Jane B; Pratap Jitesh; Kingsley Paul D; van Wijnen Andre J; Stein Janet L; Schwarz Edward M; O'Keefe Regis J; Stein Gary S; Drissi M Hicham
Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development.
Journal of cellular physiology 2005;203(1):133-43.
2005: Ito Hiromu; Koefoed Mette; Tiyapatanaputi Prarop; Gromov Kirill; Goater J Jeffrey; Carmouche Jonathan; Zhang Xinping; Rubery Paul T; Rabinowitz Joseph; Samulski R Jude; Nakamura Takashi; Soballe Kjeld; O'Keefe Regis J; Boyce Brendan F; Schwarz Edward M
Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy.
Nature medicine 2005;11(3):291-7.
2005: Clark Christine A; Schwarz Edward M; Zhang Xinping; Ziran Navid M; Drissi Hicham; O'Keefe Regis J; Zuscik Michael J
Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation.
Biochemical and biophysical research communications 2005;328(3):764-76.
2005: Blaine Theodore A; Kim Yang-Soo; Voloshin Ilya; Chen Darwin; Murakami Koko; Chang Seong-Sil; Winchester Robert; Lee Francis Y; O'keefe Regis J; Bigliani Louis U
The molecular pathophysiology of subacromial bursitis in rotator cuff disease.
Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.] 2005;14(1 Suppl S):84S-89S.
2005: Li Tian-Fang; O'Keefe Regis J; Chen Di
TGF-beta signaling in chondrocytes.
Frontiers in bioscience : a journal and virtual library 2005;10():681-8.
2004: Guldberg R E; Oest M; Lin A S P; Ito H; Chao X; Gromov K; Goater J J; Koefoed M; Schwarz E M; O'Keefe R J; Zhang X
Functional integration of tissue-engineered bone constructs.
Journal of musculoskeletal & neuronal interactions 2004;4(4):399-400.
2004: Schwarz E M; O'Keefe R J; Looney R J
Bone implant interface, osteolysis and potential therapies.
Journal of musculoskeletal & neuronal interactions 2004;4(4):390-2.
2004: Tiyapatanaputi Prarop; Rubery Paul T; Carmouche Jonathan; Schwarz Edward M; O'keefe Regis J; Zhang Xinping
A novel murine segmental femoral graft model.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004;22(6):1254-60.
2004: Li Tian-Fang; Zuscik Michael J; Ionescu Andreia M; Zhang Xinping; Rosier Randy N; Schwarz Edward M; Drissi Hicham; O'Keefe Regis J
PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling.
Experimental cell research 2004;300(1):159-69.
2004: Ritchlin C T; Schwarz E M; O'Keefe R J; Looney R J
RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis.
Journal of musculoskeletal & neuronal interactions 2004;4(3):276-84.
2004: Li Tian-Fang; Dong Yufeng; Ionescu Andreia M; Rosier Randy N; Zuscik Michael J; Schwarz Edward M; O'Keefe Regis J; Drissi Hicham
Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway.
Experimental cell research 2004;299(1):128-36.
2004: Ulrich-Vinther M; Duch M R; Søballe K; O'Keefe R J; Schwarz E M; Pedersen F S
In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004;22(4):726-34.
2004: Ferguson Cristin M; Schwarz Edward M; Puzas J Edward; Zuscik Michael J; Drissi Hicham; O'Keefe Regis J
Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004;22(4):687-96.
2004: Zhang Xinping; Ziran Navid; Goater J Jeffery; Schwarz Edward M; Puzas J Edward; Rosier Randy N; Zuscik Michael; Drissi Hicham; O'Keefe Regis J
Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation.
Bone 2004;34(5):809-17.
2004: Zuscik Michael J; Baden Jonathan F; Wu Qiuqian; Sheu Tzong J; Schwarz Edward M; Drissi Hicham; O'Keefe Regis J; Puzas J Edward; Rosier Randy N
5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes.
Journal of cellular biochemistry 2004;92(2):316-31.
2004: Ionescu Andreia M; Drissi Hicham; Schwarz Edward M; Kato Mitsuyasu; Puzas J Edward; McCance Dennis J; Rosier Randy N; Zuscik Michael J; O'Keefe Regis J
CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter.
Journal of cellular physiology 2004;198(3):428-40.
2004: Li Ping; Schwarz Edward M; O'Keefe Regis J; Ma Lin; Boyce Brendan F; Xing Lianping
RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(2):207-13.
2004: Li Ping; Schwarz Edward M; O'Keefe Regis J; Ma Lin; Looney R John; Ritchlin Christopher T; Boyce Brendan F; Xing Lianping
Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice.
Arthritis and rheumatism 2004;50(1):265-76.
2004: Ito H; Goater J J; Tiyapatanaputi P; Rubery P T; O'Keefe R J; Schwarz E M
Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells.
Gene therapy 2004;11(1):34-41.
2004: Bukata Susan V; Gelinas Jill; Wei Xiaochao; Rosier Randy N; Puzas J Edward; Zhang Xinping; Schwarz Edward M; Song Xiao-yu R; Griswold Don E; O'Keefe Regis J
PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004;22(1):6-12.
2003: Puzas J E; O'Keefe R J; Schwarz E M; Zhang X
Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition.
Journal of musculoskeletal & neuronal interactions 2003;3(4):308-12; discussion 320-1.
2003: Drissi M Hicham; Li Xufeng; Sheu Tzong J; Zuscik Michael J; Schwarz Edward M; Puzas J Edward; Rosier Randy N; O'Keefe Regis J
Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes.
Journal of cellular biochemistry 2003;90(6):1287-98.
2003: Huang W; Drissi M H; O'Keefe R J; Schwarz E M
A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesis.
Calcified tissue international 2003;73(6):584-93.
2003: Ulrich-Vinther Michael; Maloney Michael D; Schwarz Edward M; Rosier Randy; O'Keefe Regis J
Articular cartilage biology.
The Journal of the American Academy of Orthopaedic Surgeons 2003;11(6):421-30.
2003: Schwarz Edward M; Campbell Debbie; Totterman Saara; Boyd Allen; O'Keefe Regis J; Looney R John
Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(6):1049-55.
2003: O'Keefe Regis J; Guise Theresa A
Molecular mechanisms of bone metastasis and therapeutic implications.
Clinical orthopaedics and related research 2003;(415 Suppl):S100-4.
2003: Andela Valentine B; Gordon Andrew H; Zotalis George; Rosier Randy N; Goater Jeffrey J; Lewis Gregory D; Schwarz Edward M; Puzas J Edward; O'Keefe Regis J
NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone.
Clinical orthopaedics and related research 2003;(415 Suppl):S75-85.
2003: Andela Valentine B; Pirri Michael; Schwarz Edward M; Puzas Edward J; O'Keefe Regis J; Rosenblatt Joseph D; Rosier Randy N
The mevalonate synthesis pathway as a therapeutic target in cancer.
Clinical orthopaedics and related research 2003;(415 Suppl):S59-66.
2003: Zhang Donghui; Schwarz Edward M; Rosier Randy N; Zuscik Michael J; Puzas J Edward; O'Keefe Regis J
ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(9):1593-604.
2003: Li Xeufeng; Ionescu Andreia M; Schwarz Edward M; Zhang Xinping; Drissi Hicham; Puzas J Edward; Rosier Randy N; Zuscik Michael J; O'Keefe Regis J
Smad6 is induced by BMP-2 and modulates chondrocyte differentiation.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(5):908-13.
2003: Ionescu Andreia M; Schwarz Edward M; Zuscik Michael J; Drissi Hicham; Puzas J Edward; Rosier Randy N; O'Keefe Regis J
ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation.
Experimental cell research 2003;288(1):198-207.
2003: Flick Lisa M; Weaver Jason M; Ulrich-Vinther Michael; Abuzzahab Faruk; Zhang Xinping; Dougall William C; Anderson Dirk; O'Keefe Regis J; Schwarz Edward M
Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(4):676-84.
2003: Li Xuefeng; Schwarz Edward M; Zuscik Michael J; Rosier Randy N; Ionescu Andreia M; Puzas J Edward; Drissi Hicham; Sheu Tzong-Jen; O'Keefe Regis J
Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5.
Endocrinology 2003;144(6):2514-23.
2003: Ballock R Tracy; O'Keefe Regis J
Physiology and pathophysiology of the growth plate.
Birth defects research. Part C, Embryo today : reviews 2003;69(2):123-43.
2003: Andela Valentine B; Gingold Brett I; Souza Mary D; O'Keefe Regis J; Puzas Edward J; Schwarz Edward M; Rosier Randy N
Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB.
Cancer letters 2003;194(1):37-43.
2003: Ballock R Tracy; O'Keefe Regis J
The biology of the growth plate.
The Journal of bone and joint surgery. American volume 2003;85-A(4):715-26.
2003: Sheu Tzong-Jen; Schwarz Edward M; Martinez Daniel A; O'Keefe Regis J; Rosier Randy N; Zuscik Michael J; Puzas J Edward
A phage display technique identifies a novel regulator of cell differentiation.
The Journal of biological chemistry 2003;278(1):438-43.
2003: Huang Willis; O'Keefe Regis J; Schwarz Edward M
Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation.
Arthritis research & therapy 2003;5(1):R49-59.
2002: Pateder Dhruv B; Gish Michael W; O'Keefe Regis J; Hicks David G; Teot Lisa A; Rosier Randy N
Parathyroid hormone-related Peptide expression in cartilaginous tumors.
Clinical orthopaedics and related research 2002;(403):198-204.
2002: Zuscik Michael J; O'Keefe Regis J; Gunter Thomas E; Puzas J Edward; Schwarz Edward M; Rosier Randy N
Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(5):1079-90.
2002: Andela Valentine B; Sheu Tzong-Jen; Puzas Edward J; Schwarz Edward M; O'Keefe Regis J; Rosier Randy N
Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB.
Biochemical and biophysical research communications 2002;297(2):237-41.
2002: Ulrich-Vinther Michael; Maloney Michael D; Goater J Jeffrey; Søballe Kjeld; Goldring Mary B; O'Keefe Regis J; Schwarz Edward M
Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes.
Arthritis and rheumatism 2002;46(8):2095-104.
2002: Ulrich-Vinther Michael; Carmody Emily E; Goater J Jeffrey; S balle Kjeld; O'Keefe Regis J; Schwarz Edward M
Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis.
The Journal of bone and joint surgery. American volume 2002;84-A(8):1405-12.
2002: Zuscik Michael J; Pateder Dhruv B; Puzas J Edward; Schwarz Edward M; Rosier Randy N; O'Keefe Regis J
Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(4):811-8.
2002: Soloviev Alexander; Schwarz Edward M; Kuprash Dmitry V; Nedospasov Sergei A; Puzas J Edward; Rosier Randy N; O'Keefe Regis J
The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(4):714-22.
2002: Guilak Farshid; Kapur Ravi; Sefton Michael V; Vandenburgh Herman H; Koretsky Alan P; Kriete Andres; O'Keefe Regis J
Functional assessment of engineered tissues and elements of tissue design: breakout session summary.
Annals of the New York Academy of Sciences 2002;961():207-9.
2002: O'Keefe Regis J
Determination of responsiveness in biological systems is dependent on highly sensitive quantitative measures.
Annals of the New York Academy of Sciences 2002;961():206.
2002: Zhang Xinping; Schwarz Edward M; Young Donald A; Puzas J Edward; Rosier Randy N; O'Keefe Regis J
Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair.
The Journal of clinical investigation 2002;109(11):1405-15.
2002: Zuscik Michael J; D'Souza Mary; Ionescu Andreia M; Gunter Karlene K; Gunter Thomas E; O'Keefe Regis J; Schwarz Edward M; Puzas J Edward; Rosier Randy N
Growth plate chondrocyte maturation is regulated by basal intracellular calcium.
Experimental cell research 2002;276(2):310-9.
2002: Carmody Emily E; Schwarz Edward M; Puzas J Edward; Rosier Randy N; O'Keefe Regis J
Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles.
Arthritis and rheumatism 2002;46(5):1298-308.
2002: Sheu Tzong-Jen; Schwarz Edward M; O'Keefe Regis J; Rosier Randy N; Puzas J Edward
Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(5):915-22.
2002: Andela Valentine B; Rosenblatt Joseph D; Schwarz Edward M; Puzas Edward J; O'Keefe Regis J; Rosier Randy N
Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis.
Clinical orthopaedics and related research 2002;(397):228-39.
2002: Goater J Jeffrey; O'Keefe Regis J; Rosier Randy N; Puzas J Edward; Schwarz Edward M
Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(2):169-73.
2002: Good Christopher R; O'Keefe Regis J; Puzas J Edward; Schwarz Edward M; Rosier Randy N
Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors.
Journal of surgical oncology 2002;79(3):174-9.
2002: Zhang Donghui; Ferguson Cristin M; O'Keefe Regis J; Puzas J Edward; Rosier Randy N; Reynolds Paul R
A role for the BMP antagonist chordin in endochondral ossification.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(2):293-300.
2002: Childs Lisa M; Paschalis Eleftherios P; Xing Lianping; Dougall William C; Anderson Dirk; Boskey Adele L; Puzas J Edward; Rosier Randy N; O'Keefe Regis J; Boyce Brendan F; Schwarz Edward M
In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(2):192-9.
2002: Mungo David V; Zhang Xinping; O'Keefe Regis J; Rosier Randy N; Puzas J Edward; Schwarz Edward M
COX-1 and COX-2 expression in osteoid osteomas.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(1):159-62.
2002: Puzas J Edward; O'Keefe Regis J; Lieberman Jay R
The orthopaedic genome: what does the future hold and are we ready?
The Journal of bone and joint surgery. American volume 2002;84-A(1):133-41.
2002: Pateder Dhruv B; Sheu Tzong Jen; O'Keefe Regis J; Puzas J Edward; Schwarz Edward M; Constine Louis S; Okunieff Paul; Rosier Randy N
Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes.
Radiation research 2002;157(1):62-8.
2002: Looney R John; Boyd Allen; Totterman Saara; Seo Gwy-Suk; Tamez-Pena Jose; Campbell Debbie; Novotny Leonore; Olcott Christopher; Martell John; Hayes F Ann; O'Keefe Regis J; Schwarz Edward M
Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear.
Arthritis research 2002;4(1):59-63.
2001: Childs L M; Goater J J; O'Keefe R J; Schwarz E M
Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis.
The Journal of bone and joint surgery. American volume 2001;83-A(12):1789-97.
2001: Pateder D B; Ferguson C M; Ionescu A M; Schwarz E M; Rosier R N; Puzas J E; O'Keefe R J
PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling.
Journal of cellular physiology 2001;188(3):343-51.
2001: Pollice P F; Rosier R N; Looney R J; Puzas J E; Schwarz E M; O'Keefe R J
Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components.
The Journal of bone and joint surgery. American volume 2001;83-A(7):1057-61.
2001: Pateder D B; Eliseev R A; O'Keefe R J; Schwarz E M; Okunieff P; Constine L S; Puzas J E; Rosier R N
The role of autocrine growth factors in radiation damage to the epiphyseal growth plate.
Radiation research 2001;155(6):847-57.
2001: Zhang X; Morham S G; Langenbach R; Young D A; Xing L; Boyce B F; Puzas E J; Rosier R N; O'Keefe R J; Schwarz E M
Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(4):660-70.
2001: Ionescu A M; Schwarz E M; Vinson C; Puzas J E; Rosier R; Reynolds P R; O'Keefe R J
PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling.
The Journal of biological chemistry 2001;276(15):11639-47.
2001: Childs L M; Goater J J; O'Keefe R J; Schwarz E M
Efficacy of etanercept for wear debris-induced osteolysis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(2):338-47.
2001: Grimsrud C D; Romano P R; D'Souza M; Puzas J E; Schwarz E M; Reynolds P R; Roiser R N; O'Keefe R J
BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2001;19(1):18-25.
2000: Andela V B; Schwarz E M; Puzas J E; O'Keefe R J; Rosier R N
Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB.
Cancer research 2000;60(23):6557-62.
2000: Ferguson C M; Schwarz E M; Reynolds P R; Puzas J E; Rosier R N; O'Keefe R J
Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation.
Endocrinology 2000;141(12):4728-35.
2000: Chi H; Yang X; Kingsley P D; O'Keefe R J; Puzas J E; Rosier R N; Shears S B; Reynolds P R
Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo.
Molecular and cellular biology 2000;20(17):6496-507.
2000: Li P; Sanz I; O'Keefe R J; Schwarz E M
NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5990-7.
2000: Schwarz E M; Lu A P; Goater J J; Benz E B; Kollias G; Rosier R N; Puzas J E; O'Keefe R J
Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(3):472-80.
2000: Reynolds S D; Zhang D; Puzas J E; O'Keefe R J; Rosier R N; Reynolds P R
Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues.
Gene 2000;248(1-2):233-43.
2000: Pateder D B; Rosier R N; Schwarz E M; Reynolds P R; Puzas J E; D'Souza M; O'Keefe R J
PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes.
Experimental cell research 2000;256(2):555-62.
2000: Goater J; Müller R; Kollias G; Firestein G S; Sanz I; O'Keefe R J; Schwarz E M
Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis.
The Journal of rheumatology 2000;27(4):983-9.
2000: Schwarz E M; Looney R J; O'Keefe R J
Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis.
Arthritis research 2000;2(3):165-8.
1999: Vena V E; Hsu J; Rosier R N; O'Keefe R J
Pelvic reconstruction for severe periacetabular metastatic disease.
Clinical orthopaedics and related research 1999;(362):171-80.
1999: Grimsrud C D; Romano P R; D'Souza M; Puzas J E; Reynolds P R; Rosier R N; O'Keefe R J
BMP-6 is an autocrine stimulator of chondrocyte differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(4):475-82.
1999: Chi H; Tiller G E; Dasouki M J; Romano P R; Wang J; O'keefe R J; Puzas J E; Rosier R N; Reynolds P R
Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19.
Genomics 1999;56(3):324-36.
1998: Pollice P F; Hsu J; Hicks D G; Bukata S; Rosier R N; Reynolds P R; Puzas J E; O'Keefe R J
Interleukin-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: evidence of an anti-inflammatory regulatory pathway.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1998;16(6):697-704.
1998: Rosier R N; O'Keefe R J; Hicks D G
The potential role of transforming growth factor beta in fracture healing.
Clinical orthopaedics and related research 1998;(355 Suppl):S294-300.
1998: Grimsrud C D; Rosier R N; Puzas J E; Reynolds P R; Reynolds S D; Hicks D G; O'Keefe R J
Bone morphogenetic protein-7 in growth-plate chondrocytes: regulation by retinoic acid is dependent on the stage of chondrocyte maturation.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1998;16(2):247-55.
1998: Romano P R; Wang J; O'Keefe R J; Puzas J E; Rosier R N; Reynolds P R
HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation.
Journal of cell science 1998;111 ( Pt 6)():803-13.
1998: O'Keefe R J; Rosier R N; Teot L A; Stewart J M; Hicks D G
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction.
The Iowa orthopaedic journal 1998;18():26-34.
1997: Blaine T A; Pollice P F; Rosier R N; Reynolds P R; Puzas J E; O'Keefe R J
Modulation of the production of cytokines in titanium-stimulated human peripheral blood monocytes by pharmacological agents. The role of cAMP-mediated signaling mechanisms.
The Journal of bone and joint surgery. American volume 1997;79(10):1519-28.
1997: Rosier R N; O'Keefe R J; Teot L A; Fox E J; Nester T A; Puzas J E; Reynolds P R; Hicks D G
P-glycoprotein expression in cartilaginous tumors.
Journal of surgical oncology 1997;65(2):95-105.
1997: O'Keefe R J; Teot L A; Singh D; Puzas J E; Rosier R N; Hicks D G
Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study.
Laboratory investigation; a journal of technical methods and pathology 1997;76(4):457-65.
1997: O'Keefe R J; Loveys L S; Hicks D G; Reynolds P R; Crabb I D; Puzas J E; Rosier R N
Differential regulation of type-II and type-X collagen synthesis by parathyroid hormone-related protein in chick growth-plate chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1997;15(2):162-74.
1996: Hicks D G; O'Keefe R J; Reynolds K J; Cory-Slechta D A; Puzas J E; Judkins A; Rosier R N
Effects of lead on growth plate chondrocyte phenotype.
Toxicology and applied pharmacology 1996;140(1):164-72.
1996: Blaine T A; Rosier R N; Puzas J E; Looney R J; Reynolds P R; Reynolds S D; O'Keefe R J
Increased levels of tumor necrosis factor-alpha and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles.
The Journal of bone and joint surgery. American volume 1996;78(8):1181-92.
1996: Teot L A; O'Keefe R J; Rosier R N; O'Connell J X; Fox E J; Hicks D G
Extraosseous primary and recurrent giant cell tumors: transforming growth factor-beta1 and -beta2 expression may explain metaplastic bone formation.
Human pathology 1996;27(7):625-32.
1996: Reynolds S D; Johnston C; Leboy P S; O'Keefe R J; Puzas J E; Rosier R N; Reynolds P R
Identification and characterization of a unique chondrocyte gene involved in transition to hypertrophy.
Experimental cell research 1996;226(1):197-207.
1996: Reynolds P R; Reynolds S D; O'Keefe R J; Puzas J E; Rosier R N
Alternative splicing of a chondrocyte-specific gene.
Annals of the New York Academy of Sciences 1996;785():321-4.
1996: Hicks D G; Judkins A R; Sickel J Z; Rosier R N; Puzas J E; O'Keefe R J
Granular histiocytosis of pelvic lymph nodes following total hip arthroplasty. The presence of wear debris, cytokine production, and immunologically activated macrophages.
The Journal of bone and joint surgery. American volume 1996;78(4):482-96.
1996: Scully S P; Temple H T; O'Keefe R J; Mankin H J; Gebhardt M
The surgical treatment of patients with osteosarcoma who sustain a pathologic fracture.
Clinical orthopaedics and related research 1996;(324):227-32.
1996: Delsignore J L; Dvoretsky P M; Hicks D G; O'Keefe R J; Rosier R N
Mastocytosis presenting as a skeletal disorder.
The Iowa orthopaedic journal 1996;16():126-34.
1995: O'Keefe R J; O'Donnell R J; Temple H T; Scully S P; Mankin H J
Giant cell tumor of bone in the foot and ankle.
Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society 1995;16(10):617-23.
1995: O'Keefe R J; O'Connell J X; Temple H T; Scully S P; Kattapuram S V; Springfield D S; Rosenberg A E; Mankin H J
Calcific myonecrosis. A late sequela to compartment syndrome of the leg.
Clinical orthopaedics and related research 1995;(318):205-13.
1995: Scully S P; Temple H T; O'Keefe R J; Scarborough M T; Mankin H J; Gebhardt M C
Role of surgical resection in pelvic Ewing's sarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(9):2336-41.
1995: Hughes S S; Hicks D G; O'Keefe R J; Hurwitz S R; Crabb I D; Krasinskas A M; Loveys L; Puzas J E; Rosier R N
Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995;10(4):533-44.
1995: Hicks D G; Gokan T; O'Keefe R J; Totterman S M; Fultz P J; Judkins A R; Meyers S P; Rubens D J; Sickel J Z; Rosier R N
Primary lymphoma of bone. Correlation of magnetic resonance imaging features with cytokine production by tumor cells.
Cancer 1995;75(4):973-80.
1995: Rosier R N; Teot L A; Hicks D G; Schwartz C; O'Keefe R J; Puzas J E
Multiple drug resistance in osteosarcoma.
The Iowa orthopaedic journal 1995;15():66-73.
1994: O'Keefe R J; Puzas J E; Loveys L; Hicks D G; Rosier R N
Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization: rapid induction of type X collagen in culture.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(11):1713-22.
1994: Scully S P; Mott M P; Temple H T; O'Keefe R J; O'Donnell R J; Mankin H J
Late recurrence of giant-cell tumor of bone. A report of four cases.
The Journal of bone and joint surgery. American volume 1994;76(8):1231-3.
1994: O'Keefe R J; Crabb I D; Puzas J E; Rosier R N
Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1994;12(3):299-310.
1994: Temple H T; Scully S P; O'Keefe R J; Rosenthal D I; Mankin H J
Clinical presentation of alveolar soft-part sarcoma.
Clinical orthopaedics and related research 1994;(300):213-8.
1994: Scully S P; Temple H T; O'Keefe R J; Gebhardt M C
Case report 830: Aneurysmal bone cyst.
Skeletal radiology 1994;23(2):157-60.
1994: Puzas J E; Hicks D G; Reynolds S D; O'Keefe R J
Regulation of osteoclastic activity in infection.
Methods in enzymology 1994;236():47-58.
1992: O'Keefe R J; Jones J A; Hurwitz S R
Bilateral sacroiliac joint fracture-dislocation requiring late coccygectomy: a case report.
The Journal of trauma 1992;33(5):793-4.
1992: O'Keefe R J; Crabb I D; Puzas J E; Rosier R N
Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7(4):397-404.
1992: Crabb I D; O'Keefe R J; Puzas J E; Rosier R N
Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes.
Calcified tissue international 1992;50(1):61-6.
1990: Crabb I D; O'Keefe R J; Puzas J E; Rosier R N
Synergistic effect of transforming growth factor beta and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1990;5(11):1105-12.
1990: O'Keefe R J; Rosier R N; Puzas J E
Differential expression of biological effects in maturationally distinct subpopulations of growth plate chondrocytes.
Connective tissue research 1990;24(1):53-66.
1989: O'Keefe R J; Crabb I D; Puzas J E; Rosier R N
Countercurrent centrifugal elutriation. High-resolution method for the separation of growth-plate chondrocytes.
The Journal of bone and joint surgery. American volume 1989;71(4):607-20.
1989: Rosier R N; O'Keefe R J; Crabb I D; Puzas J E
Transforming growth factor beta: an autocrine regulator of chondrocytes.
Connective tissue research 1989;20(1-4):295-301.
1988: O'Keefe R J; Puzas J E; Brand J S; Rosier R N
Effect of transforming growth factor-beta on DNA synthesis by growth plate chondrocytes: modulation by factors present in serum.
Calcified tissue international 1988;43(6):352-8.
1988: O'Keefe R J; Puzas J E; Brand J S; Rosier R N
Effects of transforming growth factor-beta on matrix synthesis by chick growth plate chondrocytes.
Endocrinology 1988;122(6):2953-61.

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