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James O'Kelly

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Wenwen Chien; James O'Kelly; Daning Lu; Amanda Leiter; Julia Sohn; Dong Yin; Beth Karlan; Jay Vadgama; Karen M Lyons; H Phillip Koeffler
Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis.
Nils Thoennissen; James O'Kelly; D Lu; G B Iwanski; D T La; Sam Abbassi; A Leiter; Beth Y Karlan; Rajendra Mehta; H Phillip Koeffler
Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway.
Talin Haritunians; Saskia Gueller; James O'Kelly; Robert Ilaria; H Phillip Koeffler
Novel acyl sulfonamide LY573636-sodium: effect on hematopoietic malignant cells.

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All Publications

2011: Wenwen Chien; James O'Kelly; Daning Lu; Amanda Leiter; Julia Sohn; Dong Yin; Beth Karlan; Jay Vadgama; Karen M Lyons; H Phillip Koeffler
Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis.
International journal of oncology 2011;38(6):1741-7.
2010: Nils Thoennissen; James O'Kelly; D Lu; G B Iwanski; D T La; Sam Abbassi; A Leiter; Beth Y Karlan; Rajendra Mehta; H Phillip Koeffler
Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway.
Oncogene 2010;29(2):285-96.
2008: Talin Haritunians; Saskia Gueller; James O'Kelly; Robert Ilaria; H Phillip Koeffler
Novel acyl sulfonamide LY573636-sodium: effect on hematopoietic malignant cells.
Oncology reports 2008;20(5):1237-42.
2008: Naoki Wakimoto; Ido Wolf; Dong Yin; James O'Kelly; Tadayuki Akagi; Lilach Abramovitz; Keith L Black; Hsin-Hsiung Tai; H Phillip Koeffler
Nonsteroidal anti-inflammatory drugs suppress glioma via 15-hydroxyprostaglandin dehydrogenase.
Cancer research 2008;68(17):6978-86.
2008: Naoki Wakimoto; Dong Yin; James O'Kelly; Talin Haritunians; Beth Y Karlan; Jonathan Said; Hongtao Xing; H Phillip Koeffler
Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo.
Cancer science 2008;99(9):1793-7.
2008: James O'Kelly; Alice Chung; Nathan Lemp; Katya Chumakova; Dong Yin; He-Jing Wang; Jonathan Said; Dorina Gui; Carl W Miller; Beth Y Karlan; H Phillip Koeffler
Functional domains of CCN1 (Cyr61) regulate breast cancer progression.
International journal of oncology 2008;33(1):59-67.
2007: Akio Mori; Julian C Desmond; Naoki Komatsu; James O'Kelly; Carl W Miller; Ronald Legaspi; Alberto M Marchevsky; Robert J McKenna; H Phillip Koeffler
CYR61: a new measure of lung cancer outcome.
Cancer investigation 2007;25(8):738-41.
2007: S Lehmann; James O'Kelly; S Raynaud; S E Funk; E H Sage; H Phillip Koeffler
Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice.
Leukemia 2007;21(9):1931-6.
2007: Ido Wolf; James O'Kelly; Naoki Wakimoto; Anh Nguyen; Franck Amblard; Beth Y Karlan; Jack L Arbiser; H Phillip Koeffler
Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.
International journal of oncology 2007;30(6):1529-37.
2007: Adrian F Gombart; James O'Kelly; Tsuyako Saito; H Phillip Koeffler
Regulation of the CAMP gene by 1,25(OH)2D3 in various tissues.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):552-7.
2007: T Haritunians; A Mori; James O'Kelly; Quang T Luong; Francis Giles; H Phillip Koeffler
Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma.
Leukemia 2007;21(2):333-9.
2006: Quang T Luong; James O'Kelly; Glenn D Braunstein; Jerome M Hershman; H Phillip Koeffler
Antitumor activity of suberoylanilide hydroxamic acid against thyroid cancer cell lines in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5570-7.
2006: Ido Wolf; James O'Kelly; Tami Rubinek; Min Tong; Anh Nguyen; Bryan T Lin; Hsin-Hsiung Tai; Beth Y Karlan; H Phillip Koeffler
15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer.
Cancer research 2006;66(15):7818-23.
2006: James O'Kelly; Milan Uskokovic; Nathan Lemp; Jaydutt Vadgama; H Phillip Koeffler
Novel Gemini-vitamin D3 analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway.
The Journal of steroid biochemistry and molecular biology 2006;100(4-5):107-16.
2006: Akio Mori; Sören Lehmann; James O'Kelly; Takashi Kumagai; Julian C Desmond; Milena Pervan; william mcbride; Masahiro Kizaki; H Phillip Koeffler
Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells.
Cancer research 2006;66(6):3222-9.
2005: Adrian F Gombart; Utz Krug; James O'Kelly; Eun An; Vijaya Vegesna; H Phillip Koeffler
Aberrant expression of neutrophil and macrophage-related genes in a murine model for human neutrophil-specific granule deficiency.
Journal of leukocyte biology 2005;78(5):1153-65.
2005: Sakura Sakajiri; James O'Kelly; Dong Yin; Carl W Miller; Wolf-Karsten Hofmann; Kazuo Oshimi; Lee-Yung Shih; K-H Kim; H S Sul; Charlotte H Jensen; Børge Teisner; Norihiko Kawamata; H Phillip Koeffler
Dlk1 in normal and abnormal hematopoiesis.
Leukemia 2005;19(8):1404-10.
2005: Takayuki Ikezoe; Sigal Gery; Dong Yin; James O'Kelly; Lise Binderup; Nathan Lemp; Hirokuni Taguchi; H Phillip Koeffler
CCAAT/enhancer-binding protein delta: a molecular target of 1,25-dihydroxyvitamin D3 in androgen-responsive prostate cancer LNCaP cells.
Cancer research 2005;65(11):4762-8.
2005: Takashi Kumagai; Lee-Yung Shih; Susan V Hughes; Julian C Desmond; James O'Kelly; Martin Hewison; H Phillip Koeffler
19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia.
Cancer research 2005;65(6):2488-97.
2005: Hiroshi Kawabata; Robert E Fleming; Dorina Gui; Seo Y Moon; Takayuki Saitoh; James O'Kelly; Yutaka Umehara; Yuji Wano; Jonathan W Said; H Phillip Koeffler
Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis.
Blood 2005;105(1):376-81.
2004: Xiangjun Tong; James O'Kelly; Dong Xie; Akio Mori; Nathan Lemp; Robert McKenna; Carl W Miller; H Phillip Koeffler
Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway.
Oncogene 2004;23(28):4847-55.
2004: Dong Xie; Dong Yin; Xiangjun Tong; James O'Kelly; Akio Mori; Carl Miller; Keith Black; Dorina Gui; Jonathan W Said; H Phillip Koeffler
Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways.
Cancer research 2004;64(6):1987-96.
2004: Takashi Kumagai; Takayuki Ikezoe; Dorina Gui; James O'Kelly; Xiang-Jun Tong; Fredric Cohen; Jonathan W Said; H Phillip Koeffler
RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(4):1508-20.
2003: Takashi Kumagai; James O'Kelly; Jonathan W Said; H Phillip Koeffler
Vitamin D2 analog 19-nor-1,25-dihydroxyvitamin D2: antitumor activity against leukemia, myeloma, and colon cancer cells.
Journal of the National Cancer Institute 2003;95(12):896-905.
2003: James O'Kelly; H Phillip Koeffler
Vitamin D analogs and breast cancer.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;164():333-48.
2003: Vijaya Vegesna; James O'Kelly; Jonathan Said; Milan Uskokovic; Lise Binderup; H Phillip Koeffle
Ability of potent vitamin D3 analogs to inhibit growth of prostate cancer cells in vivo.
Anticancer research 2003;23(1A):283-9.
2002: Vijaya Vegesna; James O'Kelly; Milan Uskokovic; Jonathan Said; Nathan Lemp; Takayuki Saitoh; Takayuki Ikezoe; Lise Binderup; H Phillip Koeffler
Vitamin D3 analogs stimulate hair growth in nude mice.
Endocrinology 2002;143(11):4389-96.
2002: James O'Kelly; Junichi Hisatake; Yasuko Hisatake; June Bishop; Anthony Norman; H Phillip Koeffler
Normal myelopoiesis but abnormal T lymphocyte responses in vitamin D receptor knockout mice.
The Journal of clinical investigation 2002;109(8):1091-9.
2001: X Tong; D Xie; James O'Kelly; Carl W Miller; C Muller-Tidow; H Phillip Koeffler
Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer.
The Journal of biological chemistry 2001;276(50):47709-14.
2001: D Xie; Carl W Miller; James O'Kelly; K Nakachi; Akiko Sakashita; Jonathan W Said; J Gornbein; H Phillip Koeffler
Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease.
The Journal of biological chemistry 2001;276(17):14187-94.
2001: Junichi Hisatake; James O'Kelly; Milan Uskokovic; Shigeru Tomoyasu; H Phillip Koeffler
Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells.
Blood 2001;97(8):2427-33.