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Allan Okey

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Paul C Boutros; Cindy Q Yao; John D Watson; Alexander H Wu; Ivy D Moffat; Stephenie D Prokopec; Ashley B Smith; Allan B Okey; Raimo Pohjanvirta
Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity.
Trine Celius; Andrea Pansoy; Jason Matthews; Allan B Okey; Marilyn C Henderson; Sharon K Krueger; David E Williams
Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver.
Ivy D Moffat; Paul C Boutros; Hanbo Chen; Allan B Okey; Raimo Pohjanvirta
Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities.

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2011: Paul C Boutros; Cindy Q Yao; John D Watson; Alexander H Wu; Ivy D Moffat; Stephenie D Prokopec; Ashley B Smith; Allan B Okey; Raimo Pohjanvirta
Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity.
Toxicology and applied pharmacology 2011;251(2):119-29.
2010: Trine Celius; Andrea Pansoy; Jason Matthews; Allan B Okey; Marilyn C Henderson; Sharon K Krueger; David E Williams
Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver.
Toxicology and applied pharmacology 2010;247(1):60-9.
2010: Ivy D Moffat; Paul C Boutros; Hanbo Chen; Allan B Okey; Raimo Pohjanvirta
Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities.
BMC genomics 2010;11():263.
2008: Trine Celius; Steven Roblin; Patricia A Harper; Jason Matthews; Paul C Boutros; Raimo Pohjanvirta; Allan B Okey
Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(12):2499-505.
2008: Michelle Cotterchio; Beatrice A Boucher; Michael Manno; Steven Gallinger; Allan B Okey; Patricia A Harper
Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(11):3098-107.
2008: Monique A Franc; Ivy D Moffat; Paul C Boutros; Jouni T Tuomisto; Jouko Tuomisto; Raimo Pohjanvirta; Allan B Okey
Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats.
Archives of toxicology 2008;82(11):809-30.
2008: Raimo Pohjanvirta; Paul C Boutros; Ivy D Moffat; Jere Lindén; Dominique Wendelin; Allan B Okey
Genome-wide effects of acute progressive feed restriction in liver and white adipose tissue.
Toxicology and applied pharmacology 2008;230(1):41-56.
2008: Paul C Boutros; Rui Yan; Ivy D Moffat; Raimo Pohjanvirta; Allan B Okey
Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: comparison of rat and mouse.
BMC genomics 2008;9():419.
2007: Ivy D Moffat; Paul C Boutros; Trine Celius; Jere Lindén; Raimo Pohjanvirta; Allan B Okey
microRNAs in adult rodent liver are refractory to dioxin treatment.
Toxicological sciences : an official journal of the Society of Toxicology 2007;99(2):470-87.
2007: Ivy D Moffat; Steven Roblin; Patricia A Harper; Allan B Okey; Raimo Pohjanvirta
Aryl hydrocarbon receptor splice variants in the dioxin-resistant rat: tissue expression and transactivational activity.
Molecular pharmacology 2007;72(4):956-66.
2007: Allan B Okey
An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(1):5-38.
2006: Michelle Cotterchio; Beatrice A Boucher; Michael Manno; Steven Gallinger; Allan B Okey; Patricia Harper
Dietary phytoestrogen intake is associated with reduced colorectal cancer risk.
The Journal of nutrition 2006;136(12):3046-53.
2006: Mawahib O Semeralul; Paul C Boutros; Olga Likhodi; Allan B Okey; Hubert H M Van Tol; Albert H C Wong
Microarray analysis of the developing cortex.
Journal of neurobiology 2006;66(14):1646-58.
2006: Eric J Reiner; Ray E Clement; Allan B Okey; Chris H Marvin
Advances in analytical techniques for polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and dioxin-like PCBs.
Analytical and bioanalytical chemistry 2006;386(4):791-806.
2006: Patricia A Harper; David S Riddick; Allan B Okey
Regulating the regulator: factors that control levels and activity of the aryl hydrocarbon receptor.
Biochemical pharmacology 2006;72(3):267-79.
2006: Roberta Pastorelli; Donatella Carpi; Roberta Campagna; Luisa Airoldi; Raimo Pohjanvirta; Matti Viluksela; Helen Hakansson; Paul C Boutros; Ivy D Moffat; Allan B Okey; Roberto Fanelli
Differential expression profiling of the hepatic proteome in a rat model of dioxin resistance: correlation with genomic and transcriptomic analyses.
Molecular & cellular proteomics : MCP 2006;5(5):882-94.
2006: Raimo Pohjanvirta; Marjo Niittynen; Jere Lindén; Paul C Boutros; Ivy D Moffat; Allan B Okey
Evaluation of various housekeeping genes for their applicability for normalization of mRNA expression in dioxin-treated rats.
Chemico-biological interactions 2006;160(2):134-49.
2006: Nathalie Tijet; Paul C Boutros; Ivy D Moffat; Allan B Okey; Jouko Tuomisto; Raimo Pohjanvirta
Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries.
Molecular pharmacology 2006;69(1):140-53.
2005: Paul C Boutros; Allan B Okey
Unsupervised pattern recognition: an introduction to the whys and wherefores of clustering microarray data.
Briefings in bioinformatics 2005;6(4):331-43.
2005: Allan B Okey; Monique A Franc; Ivy D Moffat; Nathalie Tijet; Paul C Boutros; Merja Korkalainen; Jouko Tuomisto; Raimo Pohjanvirta
Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: the case of the aryl hydrocarbon receptor.
Toxicology and applied pharmacology 2005;207(2 Suppl):43-51.
2005: Béatrice Séguin; Paul C Boutros; Xujian Li; Allan B Okey; Jack P Uetrecht
Gene expression profiling in a model of D-penicillamine-induced autoimmunity in the Brown Norway rat: predictive value of early signs of danger.
Chemical research in toxicology 2005;18(8):1193-202.
2005: Allan B Okey; Paul C Boutros; Patricia A Harper
Polymorphisms of human nuclear receptors that control expression of drug-metabolizing enzymes.
Pharmacogenetics and genomics 2005;15(6):371-9.
2004: Paul C Boutros; Allan B Okey
PUNS: transcriptomic- and genomic-in silico PCR for enhanced primer design.
Bioinformatics (Oxford, England) 2004;20(15):2399-400.
2004: Paul C Boutros; Ivy D Moffat; Monique A Franc; Nathalie Tijet; Jouko Tuomisto; Raimo Pohjanvirta; Allan B Okey
Dioxin-responsive AHRE-II gene battery: identification by phylogenetic footprinting.
Biochemical and biophysical research communications 2004;321(3):707-15.
2004: Daniel W Nebert; Timothy P Dalton; Allan B Okey; Frank J Gonzalez
Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.
The Journal of biological chemistry 2004;279(23):23847-50.
2004: Steven Roblin; Allan B Okey; Patricia A Harper
AH receptor antagonist inhibits constitutive CYP1A1 and CYP1B1 expression in rat BP8 cells.
Biochemical and biophysical research communications 2004;317(1):142-8.
2002: Patricia A Harper; Judy m Y Wong; Maria S M Lam; Allan B Okey
Polymorphisms in the human AH receptor.
Chemico-biological interactions 2002;141(1-2):161-87.
2002: Sherwin K B Sy; Antonio Ciaccia; Wei Li; Eve A Roberts; Allan B Okey; Werner Kalow; Bing-Kou Tang
Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression.
European journal of clinical pharmacology 2002;58(5):357-65.
2001: M A Franc; Raimo Pohjanvirta; Jouko Tuomisto; Allan B Okey
In vivo up-regulation of aryl hydrocarbon receptor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a dioxin-resistant rat model.
Biochemical pharmacology 2001;62(12):1565-78.
2001: Vural Ozdemir; Werner Kalow; Allan B Okey; Maria S M Lam; Lawrence J Albers; Christopher Reist; J Fourie; P Posner; E J Collins; R Roy
Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C-->A polymorphism in intron 1 of the CYP1A2 gene: effect of grapefruit juice and low-dose fluvoxamine.
Journal of clinical psychopharmacology 2001;21(6):603-7.
2001: JM Wong; Allan B Okey; Patricia A Harper
Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction.
Biochemical and biophysical research communications 2001;288(4):990-6.
2001: M A Franc; Raimo Pohjanvirta; Jouko Tuomisto; Allan B Okey
Persistent, low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effect on aryl hydrocarbon receptor expression in a dioxin-resistance model.
Toxicology and applied pharmacology 2001;175(1):43-53.
2001: JM Wong; Patricia A Harper; U A Meyer; K W Bock; K Morike; J Lagueux; P Ayotte; Rachel F Tyndale; Edward M Sellers; D K Manchester; Allan B Okey
Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro.
Pharmacogenetics 2001;11(1):85-94.
2000: Michael M Iba; Jacqueline Fung; JV Giannone; Allan B Okey
Comparative induction of CYP1A1 expression by pyridine and its metabolites.
Archives of biochemistry and biophysics 2000;378(2):299-310.
1999: Raimo Pohjanvirta; Matti Viluksela; Jouni T Tuomisto; M Unkila; J Karasinska; M A Franc; M Holowenko; JV Giannone; Patricia A Harper; Jouko Tuomisto; Allan B Okey
Physicochemical differences in the AH receptors of the most TCDD-susceptible and the most TCDD-resistant rat strains.
Toxicology and applied pharmacology 1999;155(1):82-95.
1998: Wei Li; Patricia A Harper; Bing-Kou Tang; Allan B Okey
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Biochemical pharmacology 1998;56(5):599-612.
1998: Raimo Pohjanvirta; JM Wong; Wei Li; Patricia A Harper; Jouko Tuomisto; Allan B Okey
Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain.
Molecular pharmacology 1998;54(1):86-93.
1998: JV Giannone; Wei Li; M Probst; Allan B Okey
Prolonged depletion of AH receptor without alteration of receptor mRNA levels after treatment of cells in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Biochemical pharmacology 1998;55(4):489-97.
1997: Allan B Okey; JV Giannone; W Smart; JM Wong; D K Manchester; N B Parker; Mark Feeley; D L Grant; A Gilman
Binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to AH receptor in placentas from normal versus abnormal pregnancy outcomes.
Chemosphere 1997;34(5-7):1535-47.
1995: Allan B Okey; David S Riddick; Patricia A Harper
Ah receptor role in TCDD toxicity: still some mysteries but no myth--a reply to the commentary by Dr. L.W.D. Weber and Dr. B.U. Stahl.
Toxicology letters 1995;75(1-3):249-54.
1995: JV Giannone; Allan B Okey; Patricia A Harper
Characterization of polyclonal antibodies to the aromatic hydrocarbon receptor.
Canadian journal of physiology and pharmacology 1995;73(1):7-17.
1995: Y Huang; Patricia A Harper; Allan B Okey
Aromatic hydrocarbon receptor in cultured fetal cells from C57BL/6J and DBA/2J mice: similarity in molecular mass to receptors in adult livers.
Canadian journal of physiology and pharmacology 1995;73(1):18-26.
1994: Allan B Okey; David S Riddick; Patricia A Harper
Molecular biology of the aromatic hydrocarbon (dioxin) receptor.
Trends in pharmacological sciences 1994;15(7):226-32.
1994: S M de Morais; JV Giannone; Allan B Okey
Photoaffinity labeling of the Ah receptor with 3-[3H]methylcholanthrene and formation of a 165-kDa complex between the ligand-binding subunit and a novel cytosolic protein.
The Journal of biological chemistry 1994;269(16):12129-36.
1994: David S Riddick; Y Huang; Patricia A Harper; Allan B Okey
2,3,7,8-Tetrachlorodibenzo-p-dioxin versus 3-methylcholanthrene: comparative studies of Ah receptor binding, transformation, and induction of CYP1A1.
The Journal of biological chemistry 1994;269(16):12118-28.
1994: Allan B Okey; David S Riddick; Patricia A Harper
The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds.
Toxicology letters 1994;70(1):1-22.
1993: Peter H Jellinck; Poh-Gek Forkert; D S Riddick; Allan B Okey; J J Michnovicz; H Leon Bradlow
Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation.
Biochemical pharmacology 1993;45(5):1129-36.
1992: Patricia A Harper; JV Giannone; Allan B Okey; Michael S Denison
In vitro transformation of the human Ah receptor and its binding to a dioxin response element.
Molecular pharmacology 1992;42(4):603-12.
1991: Patricia A Harper; C L Golas; Allan B Okey
Ah receptor in mice genetically "nonresponsive" for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells.
Molecular pharmacology 1991;40(5):818-26.
1991: Patricia A Harper; RD Prokipcak; L E Bush; C L Golas; Allan B Okey
Detection and characterization of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human colon adenocarcinoma cell line LS180.
Archives of biochemistry and biophysics 1991;290(1):27-36.
1991: RD Prokipcak; Allan B Okey
Downregulation of the Ah receptor in mouse hepatoma cells treated in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Canadian journal of physiology and pharmacology 1991;69(8):1204-10.
1991: A Lorenzen; Allan B Okey
Detection and characterization of Ah receptor in tissue and cells from human tonsils.
Toxicology and applied pharmacology 1991;107(2):203-14.
1990: RD Prokipcak; Michael S Denison; Allan B Okey
Nuclear Ah receptor from mouse hepatoma cells: effect of partial proteolysis on relative molecular mass and DNA-binding properties.
Archives of biochemistry and biophysics 1990;283(2):476-83.
1990: RD Prokipcak; Allan B Okey
Equivalent molecular mass of cytosolic and nuclear forms of Ah receptor from Hepa-1 cells determined by photoaffinity labeling with 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.
Biochemical and biophysical research communications 1990;172(2):698-704.
1990: A Lorenzen; Allan B Okey
Detection and characterization of [3H]2,3,7,8-tetrachlorodibenzo-p-dioxin binding to Ah receptor in a rainbow trout hepatoma cell line.
Toxicology and applied pharmacology 1990;106(1):53-62.
1990: C L Golas; RD Prokipcak; Allan B Okey; D K Manchester; S Safe; T Fujita
Competitive binding of 7-substituted-2,3-dichlorodibenzo-p-dioxins with human placental ah receptor--a QSAR analysis.
Biochemical pharmacology 1990;40(4):737-41.
1990: Eve A Roberts; K C Johnson; Patricia A Harper; Allan B Okey
Characterization of the Ah receptor mediating aryl hydrocarbon hydroxylase induction in the human liver cell line Hep G2.
Archives of biochemistry and biophysics 1990;276(2):442-50.
1989: RD Prokipcak; L E Faber; Allan B Okey
Characterization of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: use of chemical crosslinking and a monoclonal antibody directed against a 59-kDa protein associated with steroid receptors.
Archives of biochemistry and biophysics 1989;274(2):648-58.
1989: Michael S Denison; L M Vella; Allan B Okey
Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver: lack of sensitivity to alkaline phosphatase when compared with that of glucocorticoid receptor.
Archives of biochemistry and biophysics 1989;273(2):458-65.
1989: Eve A Roberts; L M Vella; C L Golas; L A Dafoe; Allan B Okey
Ah receptor in spleen of rodent and primate species: detection by binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Canadian journal of physiology and pharmacology 1989;67(6):594-600.
1989: Allan B Okey; L M Vella; Patricia A Harper
Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene.
Molecular pharmacology 1989;35(6):823-30.
1988: RD Prokipcak; Allan B Okey
Physicochemical characterization of the nuclear form of Ah receptor from mouse hepatoma cells exposed in culture to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Archives of biochemistry and biophysics 1988;267(2):811-28.
1988: Patricia A Harper; C L Golas; Allan B Okey
Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line.
Cancer research 1988;48(9):2388-95.
1987: D K Manchester; S K Gordon; C L Golas; Eve A Roberts; Allan B Okey
Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene.
Cancer research 1987;47(18):4861-8.
1987: Michael S Denison; L M Vella; Allan B Okey
Structure and function of the Ah receptor: sulfhydryl groups required for binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to cytosolic receptor from rodent livers.
Archives of biochemistry and biophysics 1987;252(2):388-95.
1986: Michael S Denison; Allan B Okey; J W Hamilton; S E Bloom; C F Wilkinson
Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: ontogeny in chick embryo liver.
Journal of biochemical toxicology 1986;1(3):39-49.
1986: Michael S Denison; L M Vella; Allan B Okey
Hepatic Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Partial stabilization by molybdate.
The Journal of biological chemistry 1986;261(22):10189-95.
1986: Eve A Roberts; C L Golas; Allan B Okey
Ah receptor mediating induction of aryl hydrocarbon hydroxylase: detection in human lung by binding of 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin.
Cancer research 1986;46(7):3739-43.
1986: Allan B Okey; E A Roberts; P A Harper; M S Denison
Induction of drug-metabolizing enzymes: mechanisms and consequences.
Clinical biochemistry 1986;19(2):132-41.
1986: Michael S Denison; L M Vella; Allan B Okey
Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols.
The Journal of biological chemistry 1986;261(9):3987-95.
1986: M S Denison; P A Harper; Allan B Okey
Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Codistribution of unoccupied receptor with cytosolic marker enzymes during fractionation of mouse liver, rat liver and cultured Hepa-1c1 cells.
European journal of biochemistry / FEBS 1986;155(2):223-9.
1984: Allan B Okey; L M Vella; F Iverson
Ah receptor in primate liver: binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and carcinogenic aromatic hydrocarbons.
Canadian journal of physiology and pharmacology 1984;62(10):1292-5.
1984: Allan B Okey; A W Dubé; L M Vella
Binding of benzo(a)pyrene and dibenz(a,h)anthracene to the Ah receptor in mouse and rat hepatic cytosols.
Cancer research 1984;44(4):1426-32.
1984: Allan B Okey; L M Vella
Elevated binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene to the Ah receptor in hepatic cytosols from phenobarbital-treated rats and mice.
Biochemical pharmacology 1984;33(4):531-8.
1982: Allan B Okey; L M Vella
Binding of 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin to a common Ah receptor site in mouse and rat hepatic cytosols.
European journal of biochemistry / FEBS 1982;127(1):39-47.