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Masayasu Okochi

Research Profile

Disorders

Alzheimer's Disease

Chemicals & Drugs

Physiology

Mutation

Anatomy

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Japan

Genes & Molecular Sequences

Concepts & Ideas

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Publications

TOP 3
Kazutaka Ohi; Takashi Ohnishi; Masayasu Okochi; Shinji Tagami; Hidetoshi Takahashi; Toshihisa Tanaka; Hitoshi Tanimukai; Hidenaga Yamamori; Yuka Yasuda; Tetsuhiko Yoshida; Michiyo Azechi; Motoyuki Fukumoto; Ryota Hashimoto; Naomi Iike; Koji Ikezawa; Masao Iwase; Kouzin Kamino; Hiroaki Kazui; Takashi Kudo; Takashi Morihara; Kiyotaka Nemoto; Masatoshi Takeda
The AKT1 gene is associated with attention and brain morphology in schizophrenia.
Masayasu Okochi; Shinji Tagami; Mako Takami; Yasuo Ihara; Takashi S Kodama; Kohji Mori; Taisuke Nakayama; Kanta Yanagida; Masatoshi Takeda
γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.
Yukako Sakagami; Hitoshi Tanimukai; Kikumi Horiguchi; Kazunori Imaizumi; Daisuke Kanayama; Takashi Kudo; Masayasu Okochi; Tsubasa Omi; Masatoshi Takeda
Involvement of endoplasmic reticulum stress in tauopathy.

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All Publications

2013: Kazutaka Ohi; Takashi Ohnishi; Masayasu Okochi; Shinji Tagami; Hidetoshi Takahashi; Toshihisa Tanaka; Hitoshi Tanimukai; Hidenaga Yamamori; Yuka Yasuda; Tetsuhiko Yoshida; Michiyo Azechi; Motoyuki Fukumoto; Ryota Hashimoto; Naomi Iike; Koji Ikezawa; Masao Iwase; Kouzin Kamino; Hiroaki Kazui; Takashi Kudo; Takashi Morihara; Kiyotaka Nemoto; Masatoshi Takeda
The AKT1 gene is associated with attention and brain morphology in schizophrenia.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2013;14(2):100-13.
2013: Masayasu Okochi; Shinji Tagami; Mako Takami; Yasuo Ihara; Takashi S Kodama; Kohji Mori; Taisuke Nakayama; Kanta Yanagida; Masatoshi Takeda
γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.
Cell reports 2013;3(1):42-51.
2013: Yukako Sakagami; Hitoshi Tanimukai; Kikumi Horiguchi; Kazunori Imaizumi; Daisuke Kanayama; Takashi Kudo; Masayasu Okochi; Tsubasa Omi; Masatoshi Takeda
Involvement of endoplasmic reticulum stress in tauopathy.
Biochemical and biophysical research communications 2013;430(2):500-4.
2012: Masatoshi Takeda; Toshihisa Tanaka; Masayasu Okochi; Hiromitsu Kazui
Non-pharmacological intervention for dementia patients.
Psychiatry and clinical neurosciences 2012;66(1):1-7.
2012: Naoyuki Sato; Mitsuru Shinohara; Motoko Shinohara-Noma; Masatoshi Takeda; Shuko Takeda; Gopal Thinakaran; Akio Fukumori; Hizuki Hamada; Mari Mori-Ueda; Masayasu Okochi; Hiromi Rakugi; Ryuichi Morishita
Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs.
PloS one 2012;7(11):e48551.
2011: Teruhiko Mitsuda; Masayasu Okochi; Tsubasa Omi; Yukako Sakagami; Shinji Tagami; Takashi Kudo; Hitoshi Tanimukai; Masatoshi Takeda
Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.
Biochemical and biophysical research communications 2011;415(3):519-25.
2011: Masayasu Okochi; Masatoshi Takeda
[Behavioral and psychological symptoms of dementia].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 8():308-12.
2011: Masatoshi Takeda; Toshihisa Tanaka; Masayasu Okochi
New drugs for Alzheimer's disease in Japan.
Psychiatry and clinical neurosciences 2011;65(5):399-404.
2011: Kiyoko Kato; Takashi Kodama; Takashi Kudo; Daisuke Maruyama; Takashi Morihara; Masayasu Okochi; Golam Sadik; Shinji Tagami; Toshihisa Tanaka; Kanta Yanagida; Miyako Baba; Masatoshi Takeda
Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 2011;11(2):90-7.
2010: Ryota Hashimoto; Kazutaka Ohi; Yuka Yasuda; Motoyuki Fukumoto; Masao Iwase; Naomi Iike; Michiyo Azechi; Kazuhiko Ikezawa; Masahiko Takaya; Hidetoshi Takahashi; Hidenaga Yamamori; Tomo Okochi; Hitoshi Tanimukai; Shinji Tagami; Takashi Morihara; Masayasu Okochi; Toshihisa Tanaka; Takashi Kudo; Hiroaki Kazui; Nakao Iwata; Masatoshi Takeda
The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(8):1459-64.
2010: Masatoshi Takeda; Rocío Martínez; Takashi Kudo; Toshihisa Tanaka; Masayasu Okochi; Shinji Tagami; Takashi Morihara; Ryota Hashimoto; Ramón Cacabelos
Apolipoprotein E and central nervous system disorders: reviews of clinical findings.
Psychiatry and clinical neurosciences 2010;64(6):592-607.
2010: Yuka Yasuda; Ryota Hashimoto; Kazutaka Ohi; Motoyuki Fukumoto; Hironori Takamura; Naomi Iike; Tetsuhiko Yoshida; Noriyuki Hayashi; Hidetoshi Takahashi; Hidenaga Yamamori; Takashi Morihara; Shinji Tagami; Masayasu Okochi; Toshihisa Tanaka; Takashi Kudo; Kouzin Kamino; RYOUHEI ISHII; Masao Iwase; Hiroaki Kazui; Masatoshi Takeda
Association study of KIBRA gene with memory performance in a Japanese population.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2010;11(7):852-7.
2010: Kohji Mori; Masayasu Okochi; Shinji Tagami; Taisuke Nakayama; Kanta Yanagida; Takashi S Kodama; Shin-ichi Tatsumi; Kana Fujii; Hitoshi Tanimukai; Ryota Hashimoto; Takashi Morihara; Toshihisa Tanaka; Takashi Kudo; Satoru Funamoto; Yasuo Ihara; Masatoshi Takeda
The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 2010;10(3):117-23.
2010: Masayasu Okochi; Shinji Tagami; Kanta Yanagida; Masatoshi Takeda
[Surrogate marker for ABeta42].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 2010;30(4):169-72.
2010: Kazutaka Ohi; Ryota Hashimoto; Yuka Yasuda; Tetsuhiko Yoshida; Hidetoshi Takahashi; Naomi Iike; Masao Iwase; Kouzin Kamino; RYOUHEI ISHII; Hiroaki Kazui; Motoyuki Fukumoto; Hironori Takamura; Hidenaga Yamamori; Michiyo Azechi; Kazuhiko Ikezawa; Hitoshi Tanimukai; Shinji Tagami; Takashi Morihara; Masayasu Okochi; Kazuo Yamada; Shusuke Numata; Masashi Ikeda; Toshihisa Tanaka; Takashi Kudo; Shu-Ichi Ueno; Takeo Yoshikawa; Tetsuro Ohmori; Nakao Iwata; Norio Ozaki; Masatoshi Takeda
The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.
Schizophrenia research 2010;116(2-3):126-32.
2010: Noriyuki Hayashi; Hiroaki Kazui; Kouzin Kamino; Hiromasa Tokunaga; Masahiko Takaya; Mikiko Yokokoji; Ryo Kimura; Yumiko Kito; Tamiki Wada; Keiko Nomura; Hiromichi Sugiyama; Daisuke Yamamoto; Tetsuhiko Yoshida; Antonio Currais; Salvador Soriano; Toshimitsu Hamasaki; Mitsuko Yamamoto; Yuka Yasuda; Ryota Hashimoto; Hitoshi Tanimukai; Shinji Tagami; Masayasu Okochi; Toshihisa Tanaka; Takashi Kudo; Takashi Morihara; Masatoshi Takeda
KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.
Dementia and geriatric cognitive disorders 2010;30(4):302-8.
2010: Masatoshi Takeda; Ryota Hashimoto; Takashi Kudo; Masayasu Okochi; Shinji Tagami; Takashi Morihara; Golam Sadick; Toshihisa Tanaka
Laughter and humor as complementary and alternative medicines for dementia patients.
BMC complementary and alternative medicine 2010;10():28.
2010: Masayasu Okochi; Shinji Tagami; Masatoshi Takeda
Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients.
Neuro-degenerative diseases 2010;7(1-3):42-5.
2009: Kanta Yanagida; Masayasu Okochi; Shinji Tagami; Taisuke Nakayama; Takashi S Kodama; Kouhei Nishitomi; Jingwei Jiang; Kohji Mori; Shin-Ichi Tatsumi; Tetsuaki Arai; Takeshi Ikeuchi; Kensaku Kasuga; Takahiko Tokuda; Masaki Kondo; Masaki Ikeda; Kentaro Deguchi; Hiroaki Kazui; Toshihisa Tanaka; Takashi Morihara; Ryota Hashimoto; Takashi Kudo; Harald Steiner; Christian Haass; Kuniaki Tsuchiya; Haruhiko Akiyama; Ryozo Kuwano; Masatoshi Takeda
The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.
EMBO molecular medicine 2009;1(4):223-35.
2009: K Ohi; Ryota Hashimoto; Yoshitaka Yasuda; M Kiribayashi; N Iike; Toshiomi Yoshida; M Azechi; Kazuhiko Ikezawa; H Takahashi; Takashi Morihara; RYOUHEI ISHII; Shinji Tagami; Masao Iwase; Masayasu Okochi; Kouzin Kamino; Hiroaki Kazui; Toshiyuki Tanaka; Takashi Kudo; Masatoshi Takeda
TATA box-binding protein gene is associated with risk for schizophrenia, age at onset and prefrontal function.
Genes, brain, and behavior 2009;8(4):473-80.
2009: Naohiro Itoh; Masayasu Okochi; Shinji Tagami; Kouhei Nishitomi; Taisuke Nakayama; Kanta Yanagida; Akio Fukumori; Jingwei Jiang; Kohji Mori; Motoko Hosono; Jyunko Kikuchi; Yuko Nakano; Yoshihiko Takinami; Keiji Dohi; Atsuko Nishigaki; Hiroshi Takemoto; Kazuyuki Minagawa; Takaaki Katoh; Michael Willem; Christian Haass; Takashi Morihara; Toshihisa Tanaka; Takashi Kudo; Hiroshi Hasegawa; Masaki Nishimura; Gaku Sakaguchi; Akira Kato; Masatoshi Takeda
Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor.
Neuro-degenerative diseases 2009;6(5-6):230-9.
2008: Hidetoshi Takahashi; Masao Iwase; RYOUHEI ISHII; Kazutaka Ohi; Motoyuki Fukumoto; Michiyo Azechi; Kazuhiko Ikezawa; Ryu Kurimoto; Leonides Canuet; Takayuki Nakahachi; Naomi Iike; Shinji Tagami; Takashi Morihara; Masayasu Okochi; Toshihisa Tanaka; Hiroaki Kazui; Tetsuhiko Yoshida; Hitoshi Tanimukai; Yuka Yasuda; Takashi Kudo; Ryota Hashimoto; Masatoshi Takeda
Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia.
Neuroscience research 2008;62(3):187-94.
2008: Kiyoko Okamoto; Yoshio Mori; Yasumasa Komoda; Toru Okamoto; Masayasu Okochi; Masatoshi Takeda; Tetsuro Suzuki; Kohji Moriishi; Yoshiharu Matsuura
Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation.
Journal of virology 2008;82(17):8349-61.
2008: Shinji Tagami; Masayasu Okochi; Akio Fukumori; Jingwei Jiang; Kanta Yanagida; Taisuke Nakayama; Takashi Morihara; Toshihisa Tanaka; Takashi Kudo; Masatoshi Takeda
Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase.
Neuro-degenerative diseases 2008;5(3-4):160-2.
2008: Shinji Tagami; Masayasu Okochi; Kanta Yanagida; Akiko Ikuta; Akio Fukumori; Naohiko Matsumoto; Yoshiko Ishizuka-Katsura; Taisuke Nakayama; Naohiro Itoh; Jingwei Jiang; Kouhei Nishitomi; Kouzin Kamino; Takashi Morihara; Ryota Hashimoto; Toshihisa Tanaka; Takashi Kudo; Shigeru Chiba; Masatoshi Takeda
Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1.
Molecular and cellular biology 2008;28(1):165-76.
2007: Masatoshi Takeda; Masayasu Okochi; Shinji Tagami; Toshihisa Tanaka; Takashi Kudo
Biological markers as outcome measures for Alzheimer's disease interventions--real problems and future possibilities.
International psychogeriatrics / IPA 2007;19(3):391-400.
2006: Hisashi Tanii; Jingwei Jiang; Akio Fukumori; Shinji Tagami; Yuji Okazaki; Masayasu Okochi; Masatoshi Takeda
Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.
Journal of neuroscience research 2006;84(4):918-25.
2006: Takashi Kudo; Masayo Okumura; Kazunori Imaizumi; Wataru Araki; Takashi Morihara; Hitoshi Tanimukai; Eiichiro Kamagata; Nobuhiko Tabuchi; Ryo Kimura; Daisuke Kanayama; Akio Fukumori; Shinji Tagami; Masayasu Okochi; Mikiko Kubo; Hisashi Tanii; Masaya Tohyama; Takeshi Tabira; Masatoshi Takeda
Altered localization of amyloid precursor protein under endoplasmic reticulum stress.
Biochemical and biophysical research communications 2006;344(2):525-30.
2006: Naoyuki Sato; Masayasu Okochi; Yoshiaki Taniyama; Hitomi Kurinami; Munehisa Shimamura; Daisuke Takeuchi; Hizuki Hamada; Akio Fukumori; Kazuyuki Kiyosue; Takahisa Taguchi; Toshiyuki Tanaka; Masayuki Miyasaka; Masatoshi Takeda; Toshio Ogihara; Ryuichi Morishita
Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils.
Neurobiology of disease 2006;22(3):487-95.
2006: Akio Fukumori; Masayasu Okochi; Shinji Tagami; Jingwei Jiang; Naohiro Itoh; Taisuke Nakayama; Kanta Yanagida; Yoshiko Ishizuka-Katsura; Takashi Morihara; Kouzin Kamino; Toshihisa Tanaka; Takashi Kudo; Hisashi Tanii; Akiko Ikuta; Christian Haass; Masatoshi Takeda
Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.
Biochemistry 2006;45(15):4907-14.
2006: Masayasu Okochi; Akio Fukumori; Jingwei Jiang; Naohiro Itoh; Ryo Kimura; Harald Steiner; Christian Haass; Shinji Tagami; Masatoshi Takeda
Secretion of the Notch-1 Abeta-like peptide during Notch signaling.
The Journal of biological chemistry 2006;281(12):7890-8.
2004: Masatoshi Takeda; Toshihisa Tanaka; Takashi Kudo; Masayasu Okochi; Akihito Kamino; Shinji Tagami
[Biological markers for diagnosis of Alzheimer's disease].
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 2004;106(12):1610-4.
2004: Masayasu Okochi; Masatoshi Takeda
[Familial Alzheimer's disease by beta-amyloid protein precursor (beta APP) mutations].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl():86-9.
2002: Takashi Kudo; Taiichi Katayama; Kazunori Imaizumi; Yuka Yasuda; Misako Yatera; Masayasu Okochi; Masaya Tohyama; Masatoshi Takeda
The unfolded protein response is involved in the pathology of Alzheimer's disease.
Annals of the New York Academy of Sciences 2002;977():349-55.
2002: Masayasu Okochi; Harald Steiner; Akio Fukumori; Hisashi Tanii; Taisuke Tomita; Toshihisa Tanaka; Takeshi Iwatsubo; Takashi Kudo; Masatoshi Takeda; Christian Haass
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
The EMBO journal 2002;21(20):5408-16.
2002: Yuka Yasuda; Takashi Kudo; Taiichi Katayama; Kazunori Imaizumi; Misako Yatera; Masayasu Okochi; Hidenaga Yamamori; Naohiko Matsumoto; Takayuki Kida; Akio Fukumori; Masayo Okumura; Masaya Tohyama; Masatoshi Takeda
FAD-linked presenilin-1 mutants impede translation regulation under ER stress.
Biochemical and biophysical research communications 2002;296(2):313-8.