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Sam Okret

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Konstantin Yakimchuk; Liying Chen; Rikard Holmdahl; Kutty Selva Nandakumar; Sam Okret; Mikael Jondal
Keratinocyte growth factor (KGF) delays the onset of collagen-induced arthritis.
Michaela Moors; Sam Okret; Raj Bose; Karin Edoff; Krishan Johansson-Haque; Sandra Ceccatelli
Dickkopf 1 mediates glucocorticoid-induced changes in human neural progenitor cell proliferation and differentiation.
Yongwen Chen; Shengjun Qiao; Jan Tuckermann; Sam Okret; Mikael Jondal
Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis.

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All Publications

2012: Konstantin Yakimchuk; Liying Chen; Rikard Holmdahl; Kutty Selva Nandakumar; Sam Okret; Mikael Jondal
Keratinocyte growth factor (KGF) delays the onset of collagen-induced arthritis.
Autoimmunity 2012;45(7):510-5.
2012: Michaela Moors; Sam Okret; Raj Bose; Karin Edoff; Krishan Johansson-Haque; Sandra Ceccatelli
Dickkopf 1 mediates glucocorticoid-induced changes in human neural progenitor cell proliferation and differentiation.
Toxicological sciences : an official journal of the Society of Toxicology 2012;125(2):488-95.
2010: Yongwen Chen; Shengjun Qiao; Jan Tuckermann; Sam Okret; Mikael Jondal
Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(12):5043-51.
2009: Shengjun Qiao; Sam Okret; Mikael Jondal
Thymocyte-synthesized glucocorticoids play a role in thymocyte homeostasis and are down-regulated by adrenocorticotropic hormone.
Endocrinology 2009;150(9):4163-9.
2009: Lars-Göran Bladh; Krishan Johansson-Haque; Ingalill Rafter; Stefan Nilsson; Sam Okret
Inhibition of extracellular signal-regulated kinase (ERK) signaling participates in repression of nuclear factor (NF)-kappaB activity by glucocorticoids.
Biochimica et biophysica acta 2009;1793(3):439-46.
2008: Krishan Johansson-Haque; Elanchelian Palanichamy; Sam Okret
Stimulation of MAPK-phosphatase 1 gene expression by glucocorticoids occurs through a tethering mechanism involving C/EBP.
Journal of molecular endocrinology 2008;41(4):239-49.
2008: Shengjun Qiao; Liying Chen; Sam Okret; Mikael Jondal
Age-related synthesis of glucocorticoids in thymocytes.
Experimental cell research 2008;314(16):3027-35.
2005: Anne-Sofie M Johansson; Johan Lidén; Sam Okret; Jan E W Palmblad
Effects of ethanol on cytokine generation and NFkappaB activity in human lung epithelial cell.
Biochemical pharmacology 2005;70(4):545-51.
2005: Ahmad Pazirandeh; Mikael Jondal; Sam Okret
Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo.
Endocrinology 2005;146(6):2501-7.
2005: Lars-Göran Bladh; Johan Lidén; Karin Dahlman-Wright; Mark Reimers; Stefan Nilsson; Sam Okret
Identification of endogenous glucocorticoid repressed genes differentially regulated by a glucocorticoid receptor mutant able to separate between nuclear factor-kappaB and activator protein-1 repression.
Molecular pharmacology 2005;67(3):815-26.
2005: Lars-Göran Bladh; Johan Lidén; Ahmad Pazirandeh; Ingalill Rafter; Karin Dahlman-Wright; Stefan Nilsson; Sam Okret
Identification of target genes involved in the antiproliferative effect of glucocorticoids reveals a role for nuclear factor-(kappa)B repression.
Molecular endocrinology (Baltimore, Md.) 2005;19(3):632-43.
2004: Mikael Jondal; Ahmad Pazirandeh; Sam Okret
Different roles for glucocorticoids in thymocyte homeostasis?
Trends in immunology 2004;25(11):595-600.
2004: Ahmad Pazirandeh; Mikael Jondal; Sam Okret
Glucocorticoids delay age-associated thymic involution through directly affecting the thymocytes.
Endocrinology 2004;145(5):2392-401.
2004: Behrous Davani; Neil Portwood; Galina Bryzgalova; martina kvist reimer; Thomas Heiden; Claes-Göran Ostenson; Sam Okret; Bo Ahren; Suad Efendic; Akhtar Khan
Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells develop diabetes.
Diabetes 2004;53 Suppl 1():S51-9.
2003: Bertrand Joseph; Asa Wallén-Mackenzie; Gérard Benoit; Takashi Murata; Eliza Joodmardi; Sam Okret; Thomas Perlmann
p57(Kip2) cooperates with Nurr1 in developing dopamine cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15619-24.
2003: Johan Lidén; Alexandra Ek; Lena Palmberg; Sam Okret; Kjell Larsson
Organic dust activates NF-kappaB in lung epithelial cells.
Respiratory medicine 2003;97(8):882-92.
2003: K Alheim; J Corness; Magnus K R Samuelsson; Lars-Göran Bladh; T Murata; T Nilsson; Sam Okret
Identification of a functional glucocorticoid response element in the promoter of the cyclin-dependent kinase inhibitor p57Kip2.
Journal of molecular endocrinology 2003;30(3):359-68.
2003: Nanthakumar Subramaniam; Javier Campión; Ingalill Rafter; Sam Okret
Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor interaction with the homoeodomain protein Pbx1.
The Biochemical journal 2003;370(Pt 3):1087-95.
2002: Magnus K R Samuelsson; Ahmad Pazirandeh; Sam Okret
A pro-apoptotic effect of the CDK inhibitor p57(Kip2) on staurosporine-induced apoptosis in HeLa cells.
Biochemical and biophysical research communications 2002;296(3):702-9.
2002: Ahmad Pazirandeh; Yintong Xue; Tore Prestegaard; Mikael Jondal; Sam Okret
Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(7):727-9.
2001: Wolfgang Doppler; M Windegger; C Soratroi; J Tomasi; Judith Lechner; S Rusconi; A C Cato; T Almlöf; J Liden; Sam Okret; Jan-�ke GUSTAFSSON; H Richard-Foy; D B Starr; Helmut Klocker; D Edwards; S Geymayer
Expression level-dependent contribution of glucocorticoid receptor domains for functional interaction with STAT5.
Molecular and cellular biology 2001;21(9):3266-79.
2001: Mikael Jondal; Ahmad Pazirandeh; Sam Okret
A role for glucocorticoids in the thymus?
Trends in immunology 2001;22(4):185-6.
2000: Behrous Davani; Akhtar Khan; Malin Hult; Eva Mårtensson; Sam Okret; Suad Efendic; Hans Jörnvall; Udo Oppermann
Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets.
The Journal of biological chemistry 2000;275(45):34841-4.
2000: Ahmad Pazirandeh; Y Xue; Sam Okret; Mikael Jondal
Glucocorticoid resistance in thymocytes from mice expressing a T cell receptor transgene.
Biochemical and biophysical research communications 2000;276(1):189-96.
2000: J Liden; Ingalill Rafter; M Truss; Jan-�ke GUSTAFSSON; Sam Okret
Glucocorticoid effects on NF-kappaB binding in the transcription of the ICAM-1 gene.
Biochemical and biophysical research communications 2000;273(3):1008-14.
1999: Magnus K R Samuelsson; Ahmad Pazirandeh; Behrous Davani; Sam Okret
p57Kip2, a glucocorticoid-induced inhibitor of cell cycle progression in HeLa cells.
Molecular endocrinology (Baltimore, Md.) 1999;13(11):1811-22.
1999: Nanthakumar Subramaniam; E Treuter; Sam Okret
Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids.
The Journal of biological chemistry 1999;274(25):18121-7.
1999: Ahmad Pazirandeh; Y Xue; Ingalill Rafter; Jan Sjövall; Mikael Jondal; Sam Okret
Paracrine glucocorticoid activity produced by mouse thymic epithelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(8):893-901.
1998: Nanthakumar Subramaniam; W Cairns; Sam Okret
Glucocorticoids repress transcription from a negative glucocorticoid response element recognized by two homeodomain-containing proteins, Pbx and Oct-1.
The Journal of biological chemistry 1998;273(36):23567-74.
1998: A Dumont; Steffen P Hehner; M Lienhard Schmitz; J A Gustafsson; Johan Lidén; Sam Okret; P T van der Saag; S Wissink; Bart van der Burg; P Herrlich; G Haegeman; Karolien De Bosscher; W Fiers
Cross-talk between steroids and NF-kappa B: what language?
Trends in biochemical sciences 1998;23(7):233-5.
1998: ZC Ling; Akhtar Khan; F Delauny; Behrous Davani; Claes-Göran Ostenson; J A Gustafsson; Sam Okret; BR Landau; Suad Efendic
Increased glucocorticoid sensitivity in islet beta-cells: effects on glucose 6-phosphatase, glucose cycling and insulin release.
Diabetologia 1998;41(6):634-9.
1997: F Delaunay; Aisha Khan; A Cintra; Behrous Davani; ZC Ling; A Andersson; C G Ostenson; J Gustafsson; S Efendic; Sam Okret
Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids.
The Journal of clinical investigation 1997;100(8):2094-8.
1997: J Liden; F Delaunay; Ingalill Rafter; J Gustafsson; Sam Okret
A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation.
The Journal of biological chemistry 1997;272(34):21467-72.
1997: Bart van der Burg; J Liden; Sam Okret; F Delaunay; S Wissink; Paul T van der Saag; Jan-�ke GUSTAFSSON
Nuclear factor-kappa B repression in antiinflammation and immunosuppression by glucocorticoids.
Trends in endocrinology and metabolism: TEM 1997;8(4):152-7.
1997: Nanthakumar Subramaniam; W Cairns; Sam Okret
Studies on the mechanism of glucocorticoid-mediated repression from a negative glucocorticoid response element from the bovine prolactin gene.
DNA and cell biology 1997;16(2):153-63.
1996: F Delaunay; J Liden; J A Gustafsson; Sam Okret
Glucocorticoid receptor lacking the tau 1 transactivation domain is a gene-specific regulator of the wild-type glucocorticoid-receptor activity.
European journal of biochemistry / FEBS 1996;242(3):839-45.
1996: H Matheson; C Branting; Ingalill Rafter; Sam Okret; Joseph Rafter
Increased c-fos mRNA and binding to the AP-1 recognition sequence accompanies the proliferative response to deoxycholate of HT29 cells.
Carcinogenesis 1996;17(3):421-6.
1995: E Caldenhoven; J Liden; S Wissink; A Van de Stolpe; Jan A M Raaijmakers; Leo Koenderman; Sam Okret; J A Gustafsson; Paul T van der Saag
Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids.
Molecular endocrinology (Baltimore, Md.) 1995;9(4):401-12.
1993: K L Gearing; W Cairns; Sam Okret; J A Gustafsson
Heterogeneity in the 5' untranslated region of the rat glucocorticoid receptor mRNA.
The Journal of steroid biochemistry and molecular biology 1993;46(5):635-9.
1993: C Cairns; W Cairns; Sam Okret
Inhibition of gene expression by steroid hormone receptors via a negative glucocorticoid response element: evidence for the involvement of DNA-binding and agonistic effects of the antiglucocorticoid/antiprogestin RU486.
DNA and cell biology 1993;12(8):695-702.
1993: A Cintra; V Solfrini; B Bunnemann; Sam Okret; F Bortolotti; J A Gustafsson; Kjell Fuxe
Prenatal development of glucocorticoid receptor gene expression and immunoreactivity in the rat brain and pituitary gland: a combined in situ hybridization and immunocytochemical analysis.
Neuroendocrinology 1993;57(6):1133-47.
1993: K L Gearing; J A Gustafsson; Sam Okret
Heterogeneity in the polyglutamine tract of the glucocorticoid receptor from different rat strains.
Nucleic acids research 1993;21(8):2014.
1991: W Cairns; C Cairns; Ingemar Pongratz; Lorenz Poellinger; Sam Okret
Assembly of a glucocorticoid receptor complex prior to DNA binding enhances its specific interaction with a glucocorticoid response element.
The Journal of biological chemistry 1991;266(17):11221-6.
1991: H Tanaka; Y Dong; Q Li; Sam Okret; J A Gustafsson
Identification and characterization of a cis-acting element that interferes with glucocorticoid-inducible activation of the mouse mammary tumor virus promoter.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5393-7.
1991: Sam Okret; Y Dong; M Brönnegård; J A Gustafsson
Regulation of glucocorticoid receptor expression.
Biochimie 1991;73(1):51-9.
1991: A Cintra; Kjell Fuxe; V Solfrini; Luigi F Agnati; Barbro Tinner; A C Wikström; W Staines; Sam Okret; J A Gustafsson
Central peptidergic neurons as targets for glucocorticoid action. Evidence for the presence of glucocorticoid receptor immunoreactivity in various types of classes of peptidergic neurons.
The Journal of steroid biochemistry and molecular biology 1991;40(1-3):93-103.
1991: Sam Okret; Y Dong; H Tanaka; B Cairns; J A Gustafsson
The mechanism for glucocorticoid-resistance in a rat hepatoma cell variant that contains functional glucocorticoid receptor.
The Journal of steroid biochemistry and molecular biology 1991;40(1-3):353-61.
1990: Y Dong; W Cairns; Sam Okret; J A Gustafsson
A glucocorticoid-resistant rat hepatoma cell variant contains functional glucocorticoid receptor.
The Journal of biological chemistry 1990;265(13):7526-31.
1989: Sandra Ceccatelli; A Dagerlind; Martin Schalling; A C Wikstróm; Sam Okret; J A Gustafsson; M Goldstein; Tomas Hökfelt
The glucocorticoid receptor in the adrenal gland is localized in the cytoplasm of adrenaline cells.
Acta physiologica Scandinavica 1989;137(4):559-60.
1989: Y Dong; M Aronsson; J A Gustafsson; Sam Okret
The mechanism of cAMP-induced glucocorticoid receptor expression. Correlation to cellular glucocorticoid response.
The Journal of biological chemistry 1989;264(23):13679-83.
1989: A Härfstrand; A Cintra; Kjell Fuxe; M Aronsson; A C Wikström; Sam Okret; J A Gustafsson; Luigi F Agnati
Regional differences in glucocorticoid receptor immunoreactivity among neuropeptide Y immunoreactive neurons of the rat brain.
Acta physiologica Scandinavica 1989;135(1):3-9.
1988: Y Dong; Lorenz Poellinger; J A Gustafsson; Sam Okret
Regulation of glucocorticoid receptor expression: evidence for transcriptional and posttranslational mechanisms.
Molecular endocrinology (Baltimore, Md.) 1988;2(12):1256-64.
1988: M Aronsson; Kjell Fuxe; Y Dong; Luigi F Agnati; Sam Okret; J A Gustafsson
Localization of glucocorticoid receptor mRNA in the male rat brain by in situ hybridization.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9331-5.
1988: Y Dong; Lorenz Poellinger; Sam Okret; Jan-Olov Höög; H von Bahr-Lindström; H Jörnvall; J A Gustafsson
Regulation of gene expression of class I alcohol dehydrogenase by glucocorticoids.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(3):767-71.